Search for: "fluorescent" - 220 articles found

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Article • Super-resolution miscroscopy

PEAR: setting nano-imaging in motion

Ever since the Abbe diffraction limit of conventional microscopy has been surpassed, super-resolution techniques have been diving ever deeper into the most miniscule details of molecular structures. We spoke with Prof. Dominic Zerulla, whose company PEARlabs is developing an imaging technique that sets out to push the boundaries once more – by looking at in-vivo nano-scale processes in motion.

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News • Hazardous materials

Microplastic pollution aids antibiotic resistance

According to scientists at Rice University’s George R. Brown School of Engineering, discarded polystyrene broken down into microplastics provides a cozy home not only for microbes and chemical contaminants but also for the free-floating genetic materials that deliver to bacteria the gift of resistance.

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Detection

Zybio – SARS-CoV-2 Nucleic Acid Detection Kit

Highlights: This product qualitatively detects the RNA of SARS-CoV-2 in the specimen by measuring the change of fluorescence signal intensity during RT-PCR amplification with specific primers and probes against the conserved region of ORF 1ab and N gene, using One Step RT-PCR method. The UNG-dUTP was used to minimize the possibility of contamination of PCR amplification products. In the…

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Microscopy

Hund – medicus pro Myko

Highlights:With the medicus pro Myko, a versatile laboratory microscope for medical practices, clinical laboratories and training, easy and reliable detection of mycoses in native preparations becomes available. The dedicated fluorochrome, Mykoval, is easy to use and very cost efficient.High contrast and resolutionNo cultivation necessaryLong lifetime of LED fluorescence…

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Scanner

Hamamatsu Photonics – NanoZoomer S60

Highlights:The NanoZoomer S60 delivers the perfect combination of flexibility, excellent image quality and high speed scanning. It scans double-size slides or standard-size slides and supports brightfield and fluorescence imaging.Scanning Speed:20x mode (15 × 15 mm) approx. 60 s40x mode (15 × 15 mm) approx. 150 s Capacity: 60 standard slides, 30 double size…

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Electrophoresis / Chromatogarphy

Shimadzu – HPLC / UHPLC (RUO or CE-IVD)

Highlights:Shimadzu is offering a wide range of solutions in liquid chromatography starting from standard HPLC systems to high-end UHPLC systems including compact configurations. Available with several options for ­columns switching, pre-concentration, online SPE, etc, the systems are also well recognized for coupling with highly sensitive detectors like fluorescence, radio-activity,…

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Article • An estimated 800,000 deaths in 2030

Warning of looming global liver disease pandemic

Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.

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Article • Pre-, post- and interoperative

Wearable devices in the surgical environment

Wearable technology has become an important part of medicine, from tracking vital signs to disease diagnosis. In surgery, wearable technologies can now assist, augment, and provide a means of patient assessment before, during and after surgical procedures. Wearable technologies are applied before the patient even reaches the operating room, for example in prehabilitation, i.e. pre-treatment…

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News • Blindness prevention

Blue is the clue for diabetic retinopathy risk

Researchers from Tokyo Medical and Dental University (TMDU) demonstrate a thorough and non-invasive imaging technique to identify areas of the eye affected by diabetic retinopathy (DR), a progressive eye disease associated with diabetes and a leading cause of blindness. The researchers have found that blue light can be used to probe the depths of the eye and uncover areas affected by DR.

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News • Biological image analysis

Machine learning accelerates super-resolution microscopy

Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.

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News • Cell delivery vehicles

Bio-inspired nanocontainers could enter cells and release their medical cargo

Nanocontainers can transport substances into cells where they can then take effect. This is the method used in, for example, the mRNA vaccines currently being employed against Covid-19 as well as certain cancer drugs. In research, similar transporters can also be used to deliver labelled substances into cells in order to study basic cellular functions. To take advantage of their full potential,…

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News • Genome editing

Using CRISPR to speed up Covid-19 testing

A research team led by scientists in the labs of Jennifer Doudna, David Savage and Patrick Hsu at the University of California, Berkeley, is aiming to develop a rapid Covid-19 diagnostic test that is much faster and easier to deploy than qRT-PCR. It has now combined two different types of CRISPR enzymes to create an assay that can detect small amounts of viral RNA in less than an hour. Doudna…

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News • Hydrogel framework

Synthetic tissue with growing blood vessels developed

Using lab-created tissue to heal or replace damaged organs is one of the great visions for the future of medicine. Synthetic materials could be suitable as scaffolding for tissue because, unlike natural tissues, they remain stable in the organism long enough for the body to form new natural structures. A fundamental requirement for functional tissue is that blood vessels must be able to grow in…

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News • Advanced care

This 'smart' wound dressing monitors the healing process with built-in sensors

Researchers at RMIT University in Australia have developed smart wound dressings with built-in nanosensors that glow to alert patients when a wound is not healing properly. The multifunctional, antimicrobial dressings feature fluorescent sensors that glow brightly under UV light if infection starts to set in and can be used to monitor healing progress.

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News • AI-assisted analysis

Prediciting viral infections with microscopy & deep learning

When viruses infect cells, changes in the cell nucleus occur, and these can be observed through fluorescence microscopy. Using fluoresence images from live cells, researchers at the University of Zurich have trained an artificial neural network to reliably recognize cells that are infected by adenoviruses or herpes viruses. The procedure also identifies severe acute infections at an early stage.

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News • Neuroscience

A deep dive into the brain

Researchers from ETH Zurich and University of Zurich have developed a new microscopy technique that lights up the brain with high resolution imagery. This allows neuroscientists to study brain functions and ailments more closely and non-​invasively.

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News • Targeted drug delivery

'Soft X‑ray' method opens up ways for smart nano-medicine

Before the huge potential of tiny nanocarriers for highly targeted drug delivery and environmental clean-up can be realized, scientists first need to be able to see them. Currently researchers have to rely on attaching fluorescent dyes or heavy metals to label parts of organic nanocarrier structures for investigation, often changing them in the process. A new technique using chemically-sensitive…

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News • Microscopy

New imaging technique to improve 3D printed bio-implants

University of Birmingham scientists have developed a new microscopic imaging approach to take a closer look at 3D-printing for developing future patient implants, as well as improved disease modelling and drug screening. Additive manufacturing (3D printing) platforms create bioprinted structures by moving a special bioink, containing cells, biomolecules and materials, through a narrow tube, but…

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News • Vigorous ventilation

Covid-19: Why faster air exchange in buildings is not always beneficial

Vigorous and rapid air exchanges might not always be a good thing when it comes to addressing levels of coronavirus particles in a multiroom building, according to a new modeling study. The study suggests that, in a multiroom building, rapid air exchanges can spread the virus rapidly from the source room into other rooms at high concentrations. Particle levels spike in adjacent rooms within 30…

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Article • Surgical robotics

Elevating outcomes of surgery

What’s in a name? In the case of Asensus Surgical, Inc., previously known as TransEnterix, Inc., the recent rebranding doubles as a mission statement for the manufacturer of surgical robotics systems: The initial ‘A’ stands for artificial intelligence and augmented surgery, reflecting the company’s emphasis on new technologies designed to enhance the operator’s cognition (‘sensus’…

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News • Coronavirus research

Promising SARS-CoV-2 inhibitors discovered

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease. The study is based on laboratory experiments. Extensive clinical trials are still required for their further development as…

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Video • Multiphoton microscopy gives new insights

Microscopic behaviour of developing breast cells uncovered

An improved high-tech fluorescence microscopy technique is allowing researchers to film cells inside the breast as never seen before. This new protocol provides detailed instructions on how to capture hi-res movies of cell movement, division and cooperation, in hard-to-reach regions of breast tissue. The technology – called multiphoton microscopy – uses infrared lasers to illuminate…

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News • Physics of tumours

How cancer cells shape-shift to squeeze through tissue

Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. In experiments, the team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumour tissues and squeeze past neighbouring cells. The…

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Article • Advancing diagnostic accuracy

PSMA PET/CT in prostate cancer evaluation

Hybrid PET/CT imaging can fully play to its strengths and steer treatment towards more effective procedures for diagnosing prostate cancer. The examination of the specific antigen PSMA with hybrid PET imaging enables treatment monitoring with significantly higher diagnostic accuracy than conventional imaging and therefore, Professor Clemens Cyran believes, will soon become the standard diagnostic…

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News • New microscopy approach

A smartphone-based test for Covid-19

Researchers at the University of Arizona are developing a Covid-19 testing method that uses a smartphone microscope to analyze saliva samples and deliver results in about 10 minutes. The research team, led by biomedical engineering professor Jeong-Yeol Yoon, aims to combine the speed of existing nasal swab antigen tests with the high accuracy of nasal swab PCR, or polymerase chain reaction,…

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News • Surgical endoscopy

Olympus to acquire Quest Photonic Devices

Olympus Corporation announced that it has entered into an agreement to acquire Quest Photonic Devices B.V. for up to EUR50 million including milestone payments to strengthen its surgical endoscopy capabilities. Quest offers advanced fluorescence imaging systems (FIS) for the medical field, enabling more surgical endoscopy capabilities, compared to conventional imaging technologies.

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News • Microneedles

No more needles for bloodtests?

Blood draws are no fun. They hurt. Veins can burst, or even roll — like they’re trying to avoid the needle, too. Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and…

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Article • Resecting brain tumours

Benefits of ultrasound in neurosurgical oncology

Italian neurosurgeon Professor Francesco Di Meco, explored the current and potential role of intra-operative ultrasound in neurosurgical oncology during the annual meeting of the European Association of Neurosurgical Societies (EANS) this October. The extent of resection is considered a prognostic factor in operative neuro oncology surgery and image-guided surgery is being regarded as one of the…

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News • Improving imaging

Light up diseases with 'photonic lanterns'

Researchers at Heriot-Watt University have developed a new technique that will allow medical professionals to see disease deep inside the human body in 10 times more detail. Professor Robert Thomson and his team want to improve endoscopies, when long, thin optical fibres are used to look inside the body. The new technique will open up a route to unprecedented imaging resolution, says Thomson, and…

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Article • Detecting coronavirus infections

Covid-19: CRISPR-based test gives GPs quick results

Recent research in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has identified two enzymes that can detect Covid-19 RNA as simply as a pregnancy test Jesús Pla, an eminent microbiologist at the Complutense University in Madrid, explained in our exclusive interview. CRISPR technology could help alleviate workloads in packed hospitals and expand testing to primary care and…

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News • Prototype

Portable point-of-care for Covid-19 tests

As COVID-19 continues to spread, bottlenecks in supplies and laboratory personnel have led to long waiting times for results in some areas. In a new study, University of Illinois, Urbana-Champaign researchers have demonstrated a prototype of a rapid COVID-19 molecular test and a simple-to-use, portable instrument for reading the results with a smartphone in 30 minutes, which could enable…

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News • After coronavirus infection

Study reveals why people with COVID-19 may lose their sense of smell

Researchers studying tissue removed from patients noses during surgery believe they may have discovered the reason why so many people with COVID-19 lose their sense of smell, even when they have no other symptoms. In their experiments they found extremely high levels of angiotensin converting enzyme II (ACE-2) only in the area of the nose responsible for smelling. This Enzyme is thought to be the…

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News • Joint study shows

Endoprothetic risk: Metals from implants can accumulate in bone tissue

Using highly complex analytical techniques, a group of researchers from Charité – Universitätsmedizin Berlin were able to observe in detail how different metals are released from joint implants and accumulate in the surrounding bone tissue. Findings showed a steady release of metals from various implant components. In contrast to previous assumptions, this was not related to the degree of…

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News • Temporal pressure

"Micropores": A new way to deliver drugs through the skin

Scientists from Nanyang Technological University, Singapore (NTU Singapore) and the Agency for Science, Technology and Research (A*STAR) have showed that applying “temporal pressure” to the skin of mice can create a new way to deliver drugs. In a paper published in Science Advances, the researchers showed that bringing together two magnets so that they pinch and apply pressure to a fold of…

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News • COVID-19 detection

New analyzer detects virus antibodies in 20 minutes

Researchers at Hokkaido University have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.

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News • Smart algorithm

Automated analysis of whole brain vasculature

Diseases of the brain are often associated with typical vascular changes. Now, scientists at LMU University Hospital Munich, Helmholtz Research Centre for Environmental Health and the Technical University of Munich (TUM) have come up with a technique for visualising the structures of all the brain's blood vessels – right down to the finest capillaries – including any pathological changes. So…

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News • Glioblastoma

New imaging technique to study 3D printed brain tumors

Glioblastomas are complex, fast-growing malignant brain tumors that are made up of various types of cells. Even with aggressive treatment — which often includes surgery, radiation, and chemotherapy — glioblastomas are difficult to treat, leading to an average survival of 11-15 months. In research published in Science Advances, Xavier Intes, a professor of biomedical engineering at Rensselaer,…

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Video • Exposing the enemy

New algorithm detects even the smallest cancer metastases

Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More than 90% of cancer patients die of distal metastases rather than as a direct result of the primary…

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News • Imaging the brain

Ultra-miniaturized endoscope produces HQ images

Johns Hopkins engineers have created a new lens-free ultra-miniaturized endoscope, the size of a few human hairs in width, that is less bulky and can produce higher quality images. Their findings were published in Science Advances. “Usually, you have sacrifice either size or image quality. We’ve been able to achieve both with our microendoscope,” says Mark Foster, an associate professor of…

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News • Inhalation visualised

New imaging tech gives insights into pulmonary drug delivery

Inhalation therapy is widely used for the treatment of lung diseases. Targeting of drugs to the site of disease is a major goal to improve drug efficacy and minimize side effects. Scientists at the Helmholtz Zentrum München and the Technical University of Munich have now shown that combined insight from various imaging methods allows for real-time monitoring of the dynamic process of drug…

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News • Inherited neuromuscular disease HSP

Genetic cause for hereditary spastic paraplegia identified

Scientists at St George’s, University of London, in collaboration with researchers from Germany, the USA, Tunisia and Iran have identified a new gene associated with the neuromuscular disorder, hereditary spastic paraplegia (HSP). The study, published in Nature Communications, also highlights a potential mechanism for the disease, which is already being targeted in drug trials for Alzheimer’s…

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News • Male infertility

Chlamydia discovered in testicular tissue

The potential impact of undiagnosed sexually transmitted chlamydia infection on men’s fertility has been highlighted in an Australian-led study, which for the first time found chlamydia in the testicular tissue biopsies of infertile men whose infertility had no identified cause. The researchers from Queensland University of Technology also found antibodies specific to the bacteria responsible,…

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News • t-MALDI-2

Dual-beam laser mass spectrometry gives unique insights

Cells are the basic building blocks of life – and, as such, they have been the object of intense study since the invention of the optical microscope in the 17th century. The development of mass spectrometry (MS) methods – those which define the chemical composition of cells – represented a further milestone for research in the field of cell biology. In the latest issue of the journal Nature…

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News • In focus

Universal algorithm set to boost microscopes

Scientists from EPFL have developed an algorithm that can determine whether a super-resolution microscope is operating at maximum resolution based on a single image. The method is compatible with all types of microscopes and could one day be a standard feature of automated models.

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News • Biosensors

Using smartphones to detect norovirus

A little bit of norovirus – the highly infectious microbe that causes about 20 million cases of food poisoning in the United States each year – goes a long way. Just 10 particles of the virus can cause illness in humans. A team of University of Arizona researchers has created a simple, portable and inexpensive method for detecting extremely low levels of norovirus. Jeong-Yeol Yoon, a…

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Article • Methods, quality assurance, commercial providers issues

Molecular testing takes a huge leap

In terms of success in revolutionary cancer treatment, molecular genetic examination procedures have developed immensely over recent years. They now range from conventional polymerase chain reactions (PCR) or fluorescence-in-situ hybridisation (FISH) to Next Generation Sequencing (NGS) with analysis of the entire exome or genome (Whole-Exome, WES or Whole-Genome, WGS) and of the transcriptome…

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News • Alternative ways

Plan B for cholesterol transport

Kiel biochemistry research team proves the existence of a previously unknown alternative cholesterol transport mechanism inside cells. Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighbouring cells and the surrounding environment. By means of certain proteins,…

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News • Ultra-thin and polished

Next-generation objectives push boundaries of microscopy

Olympus has broken down barriers to imaging quality with the launch of its next-generation objectives. The breakthrough polishing technique enables the company to produce ultra-thin lenses that overcome the traditional trade-off between numerical aperture (NA), flatness and chromatic correction – enabling all three parameters to be significantly improved. Olympus has harnessed this proprietary…

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News • New at Science Park

OGT celebrates opening of new Cambridge site

Oxford Gene Technology (OGT), A Sysmex Group Company, has celebrated the opening of its new facility in Cambridge, UK. The opening ceremony, which took place at the company’s new premises on the prestigious Cambridge Science Park, was attended by the Department for International Trade (DIT) and local media as well as top-level representatives from OGT and its parent company, Sysmex Corporation.…

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Sponsored • Hematology

Early sepsis indicator helps identifying patients at risk

The critical element of testing for sepsis lies not so much in the location but in the timing and rapidity of results, according to Professor Jeannine T. Holden from Beckman Coulter Early identification enables treatment protocols to be delivered more quickly, offering better patient outcomes. Those most at risk, suggests Holden, are not patients within the intensive care unit – who are already…

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Sponsored • Sysmex

With the UN-Series, the choice is yours

Using urine to obtain diagnostic insights has been done for thousands of years and still remains an important tool to obtain crucial information. Covering a range of tests, urinalysis may be used to screen for or help to diagnose ailments such as urinary tract infections, kidney disorders, liver problems, diabetes or other medical conditions, just to name a few. Because urinalysis has been around…

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News • Medical body painting

A fluorescent way to teach anatomy

Body painting is considered by some to be the most ancient form of art. Its origins stem from tribal cultures, where its use was for ritual and ceremony. Today it is a familiar sight at carnivals and sporting events. It is also a frequently observed activity within the anatomy classrooms of medical schools around the world. But now lecturers at Hull York Medical School are pioneering the use of…

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News • Dormant virus

Finding 'hidden' HIV in cells

Until now, researchers haven’t been able to accurately quantify a latent form of HIV that persists in patients’ immune cells. A new genetic technique is fast and 10 to 100 times more accurate than previous diagnostics. This hidden, inactive version of HIV embeds into cells’ genomes and can persist despite otherwise successful therapies – thwarting attempts to cure the infection. Using a…

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News • Non-invasive diagnostics

Detecting bladder cancer with atomic force microscopy

A research team led by Tufts University engineers has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features…

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News • Photonic endoscopy

Fibre probe explores the depth of our brain

This could be a major step towards a better understanding of the functions of deeply hidden brain compartments, such as the formation of memories, as well as related dysfunctions, including Alzheimer’s disease. Researchers from the Leibniz Institute of Photonic Technology (Leibniz IPHT) in Jena and the University of Edinburgh have succeeded in using a hair-thin fibre endoscope to gain insights…

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Sponsored • Product of the month

Faster decision making with Olympus’ intelligent DP74 camera

Accelerate your workflow with the intelligent, high-resolution DP74 brightfield and fluorescence camera from Olympus. Histologists and pathologists face intense, rushed workloads where every minute counts. Experience enhanced efficiency with our next-generation camera. The DP74 creates a map of where you’ve been and can easily and rapidly lead you back to previous positions on the sample,…

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News • Advanced materials

Nanocarriers open up to cancer

Nanosystems that deliver anticancer drugs or imaging materials to tumours are showing significant progress, particularly those that respond to tumour-related stimuli, according to a review published in the journal Science and Technology of Advanced Materials. However, further research is still required to make sure these delivery systems are stable, non-toxic and biodegradable. Nanocarriers…

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Sponsored • Innovation

Hematology: Advancements and future trends

While the role of the laboratory in disease diagnosis and management has expanded in recent years, causing an overwhelming rise in testing demands, the availability of skilled technologists and specialists has been diminishing. To meet the needs of an overworked and increasingly generalized workforce, today’s products not only must deliver more clinical data than ever before, but also must be…

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Sponsored • Competition

Olympus Image of the Year – Celebrating art in science

Olympus’ Image of the Year Award for light microscopy in Europe recognizes the very best in life science imaging. Inspired by the beauty and breadth of images submitted for Image of the Year 2017, Olympus is now continuing its quest for the best light microscopy art in 2018. For the chance to win one of three prizes, applicants can submit life science light microscopy images to…

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News • Oncology

Breaking through a tumor's defenses

Babraham Institute researchers have shown that some tumours use not one but two levels of protection against the immune system. Knocking out one level boosted the protective effects of the second and vice versa. The research demonstrates that a two-pronged approach targeting both cell types simultaneously may offer a promising route for the development of new cancer immunotherapies.

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News • Equipment

A tiny, more cost-effective white blood cell counter might be available soon

A thin copper wire wrapped around a channel slightly thicker than a strand of hair could be the key to manufacturing a compact electronic device capable of counting white blood cells from the comfort of one’s home, a Kennesaw State University researcher says. Hoseon Lee, an assistant professor of electrical engineering in the Southern Polytechnic College of Engineering and Engineering…

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Article • Cancer diagnostics

Progressing towards optical biopsy

Recognising malignant tissue remains a tricky task. While today, most patients undergo a biopsy, an invasive procedure where tissue is sampled, stained and assessed, researchers are exploring the potential of optical biopsy, the visual assessment of suspect tissue. The interest in optical biopsy ‘is indeed enormous,’ confirms Dr Thomas Bocklitz, physicist at Friedrich-Schiller University in…

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News • Experimental drug

Fighting Hepatitis B with 'virus-cracking' molecules

Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer. It's estimated that 2 billion people worldwide have had a hepatitis B virus infection in their lifetime, with about 250 million -- including 2 million Americans -- living with chronic infection. Although a vaccine exists, there…

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Article • Smart techniques

Machine learning is starting to reach levels of human performance

Machine learning is playing an increasing role in computer-aided diagnosis, and Big Data is beginning to penetrate oncological imaging. However, some time may pass before it truly impacts on clinical practice, according to leading UK-based German researcher Professor Julia Schnabel, who spoke during the last ESMRMB annual meeting. Machine learning techniques are starting to reach levels of human…

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News • Risk for pregnancy

How Zika infection drives fetal demise

A powerful antiviral protein may act as a checkpoint for keeping or ending a pregnancy. When exposed to Zika virus before birth, mouse fetuses with the protein commit cell suicide, while fetuses without it continued to develop. The result, published in Science Immunology, suggests that the protein, a receptor involved in immune cell signaling, plays a role in spontaneous abortions and other human…

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News • Wound care

European launch of handheld imaging technology

Smith & Nephew, the global medical technology business, announces the European launch of MolecuLight i:X, the easy to use, handheld imaging device that instantly measures wound surface area and visualises the presence and distribution of potentially harmful bacteria in wounds. Currently wound assessments are made with the naked eye which can lack the accuracy required to most effectively…

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News • Neurotransmissions

Nanosensors uncloak the mysteries of brain chemistry

Nanosensors are incredible information-gathering tools for myriad applications, including molecular targets such as the brain. Neurotransmitter molecules govern brain function through chemistry found deep within the brain, so University of California, Berkeley researchers are developing nanosensors to gain a better understanding of exactly how this all plays out. During the AVS 64th…

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News • Cancer research

Esophageal cancer “cell of origin” identified

Columbia University Medical Center (CUMC) researchers have identified cells in the upper digestive tract that can give rise to Barrett’s esophagus, a precursor to esophageal cancer. The discovery of this “cell of origin” promises to accelerate the development of more precise screening tools and therapies for Barrett’s esophagus and esophageal adenocarcinoma, the fastest growing form of…

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News • Study

Relaxing proteins may prevent dysfunction and disease

For many years, we thought that all proteins must fold into complicated shapes to fulfill their functions, looking like thousands of sets of custom-tailored locks and keys. But over the past two decades, scientists have begun to realize other proteins—including those involved in many essential cellular functions—remain fully or partially unfolded for parts of their lives. Out of this…

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News • Intraoperative molecular imaging

Tumor dye makes cancerous lymph nodes glow during surgery

Surgeons at Penn Medicine are using a fluorescent dye that makes cancerous cells glow in hopes of identifying suspicious lymph nodes during head and neck cancer procedures. Led by Jason G. Newman, MD, FACS, an associate professor of Otorhinolaryngology in the Perelman School of Medicine at the University of Pennsylvania, the study is the first in the world to look at the effectiveness of…

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Video • Cell signals

Wound healing: more complex than you think

In a sharp and pointy world, wound healing is a critical and marvelous process. Despite a tremendous amount of scientific study, many outstanding mysteries still surround the way in which cells in living tissue respond to and repair physical damage. One prominent mystery is exactly how wound-healing is triggered: A better understanding of this process is essential for developing new and improved…

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News • Sugar molecules

Sweet help for cancer detection

Scientists from the University of Würzburg have synthesized a complex sugar molecule which specifically binds to the tumor protein Galectin-1. This could help to recognize tumors at an early stage and to combat them in a targeted manner.

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Article • Achieving a faster workflow

A modular approach to urinalysis

The reasons why doctors request urinary analysis are varied – perhaps to detect a possible or suspected infection, or to screen for kidney diseases. In all cases a reliable and rapid result is the major aim. Urinary microscopy and culture have been the mainstays of urinary analysis for many, many years both of which require time and specialist handling.

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News • Blood test alternative

Oral "Hep E" test could simplify detection tremendously

A saliva test developed by researchers at the Johns Hopkins Bloomberg School of Public Health nearly matches the performance of a blood test widely used to assess recent or past hepatitis E virus infections, a new study reports. The findings could offer an easier, less expensive alternative to gathering data for studying and eventually treating the disease, which infects an estimated 20 million…

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News • Microscopy

New Olympus BX53 microscope with True Color LED

Olympus’ new BX53 microscope provides bright, sharp images with excellent color rendering performance equivalent to halogen lamps. The long-life LED light source, the True Color LED, is brighter and more uniform than a 100-watt halogen bulb – matching every contrast method and providing bright images to multi-head discussion systems for up to 26 people.

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News • Time-lapse microscopy

Image correction software simplifies quantification of stem cells

Today, tracking the development of individual cells and spotting the associated factors under the microscope is nothing unusual. However, impairments like shadows or changes in the background complicate the interpretation of data. Now, researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München have developed a software that corrects images to make hitherto hidden…

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Article • Light microscopy

An image is worth a thousand words

Light microscopy today offers a wealth of techniques that provide fascinating insights into life on subcellular level. “In light microscopy these days there are so many new techniques that each of us can only handle a subset of them,” says Christian Tischer, scientific officer in der Advanced Light Microscopy Facility of the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany,…

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News • Ophthalmology

New eye test detects earliest signs of glaucoma

A simple eye test could help solve the biggest global cause of irreversible blindness, glaucoma. In clinical trials, the pioneering diagnostic test - developed by researchers at UCL Institute of Ophthalmology and the Western Eye Hospital - allowed doctors to see individual nerve cell death in the back of the eye.

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News • Deep Learning

Deep Learning predicts hematopoietic stem cell development

Autonomous driving, automatic speech recognition, and the game Go: Deep Learning is generating more and more public awareness. Scientists at the Helmholtz Zentrum München and their partners at ETH Zurich and the Technical University of Munich (TUM) have now used it to determine the development of hematopoietic stem cells in advance. In ‘Nature Methods’ they describe how their software…

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News • Positron emission tomography

New imaging method detects prostate cancer

An international group of researchers report success in mice of a method of using positron emission tomography (PET) scans to track, in real time, an antibody targeting a hormone receptor pathway specifically involved in prostate cancer.

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Article • Infections

Carbapenem resistant strains

The increasing numbers of bacteria resistant to the newer generations of antibiotics is a public health problem on a global scale. Bacteria have an extraordinary capacity for adaptation, mutating permanently to overcome the action of our increasingly impotent antimicrobial armamentarium. A situation further aggravated by the use of the powerful ‘large spectrum’ antibiotics, creating further…

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News • Oncology

Nanoparticle creates ‘wave of destruction’ in cancer cells

Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer. Now, the ultrasmall particles – developed more than a dozen years ago by Ulrich Wiesner, the Spencer T. Olin Professor of Engineering at Cornell University – have shown they can do something even better: kill cancer cells without attaching a cytotoxic drug.

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News • Oncology

Nanovaccine could enhance cancer immunotherapy

NIBIB researchers have created a nanovaccine that could make a current approach to cancer immunotherapy more effective while also reducing side effects. The nanovaccine helps to efficiently deliver a unique DNA sequence to immune cells – a sequence derived from bacterial DNA and used to trigger an immune reaction. The nanovaccine also protects the DNA from being destroyed inside the body, where…

News • Oncology

Infra-red light to deteact early signs of oesophageal cancer

Researchers at the Cancer Research UK Cambridge Institute sprayed a dye on oesophageal tissue samples taken from people with Barrett’s oesophagus – a condition that increases the risk of developing oesophageal cancer. The dye sticks to healthy oesophageal cells but not to pre-cancerous cells. They then shone near-infrared light - which is just beyond the red colours that our eyes can normally…

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Plasma: A technology to improve bone healing?

Cold plasma looks like the glow from the “Star Wars” blue light saber but this beam of energy, made of electrons that change polarity at micro-second or nanosecond speeds, could help bones heal faster, according to researcher from the Thomas Jefferson University.

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Article • Transplants

Cell-free DNA offers several advantages

As part of a national, joint research project in cooperation with Chronix Biomedical (San Jose, CA/USA/Göttingen/Germany), Professor Michael Oellerich MD is on new biomarkers in organ transplantation, aiming to develop personalised immunosuppression for patients. This also entails the development of molecular test procedures, among others for the early detection of rejection. The keyword here is…

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News • BRIM

Technology helps ID aggressive early breast cancer

When a woman is diagnosed with the earliest stage of breast cancer, how aggressive should her treatment be? Will the non-invasive cancer become invasive? Or is it a slow-growing variety that will likely never be harmful? Researchers at the University of Michigan developed a new technology that can identify aggressive forms of ductal carcinoma in situ, or stage 0 breast cancer, from non-aggressive…

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News • Research

A pill could improve breast cancer diagnoses

The ongoing debate about breast cancer diagnostics has left many women confused — particularly over what age they should get mammograms and who needs treatment. An issue with current methods is that they often identify lumps but cannot conclusively pinpoint which ones are cancerous. To help resolve this uncertainty, researchers have developed a pill that could improve imaging techniques so that…

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News • Glioblastoma

Imaging 'toolkit' to help identify new brain tumor drug targets

Stopping the growth of blood vessels in tumours is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. While mapping vessels in tumours has proven a challenge, researchers have now developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more…

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Cancer cells poised for growth when opportunity knocks

Researchers have identified a mechanism that allows cancer cells to respond and grow rapidly when levels of sugar in the blood rise. This may help to explain why people who develop conditions in which they have chronically high sugar levels in their blood, such as obesity, also have an increased risk of developing certain types of cancer.

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News • Fluorescent agent

Injectable agent illuminates cancer during surgery

Doctors at the Duke University School of Medicine have tested a new injectable agent that causes cancer cells in a tumor to fluoresce, potentially increasing a surgeon’s ability to locate and remove all of a cancerous tumor on the first attempt. The imaging technology was developed through collaboration with scientists at Duke, the Massachusetts Institute of Technology (MIT) and Lumicell Inc.

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News • Neurodegenerative diseases

The case of the sticky protein

Proteins are like a body’s in-house Lego set. These large, complex molecules are made up of building blocks called amino acids. Most of the time, proteins fold correctly, but sometimes they can misfold. This misfolding causes the proteins to get sticky, and that can promote clumping, or aggregation, which is the hallmark of several neurodegenerative diseases such as ALS, Alzheimer’s and…

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News • Surfing DNA

Enzyme catches a ride to fight infection

Scientists have shown for the first time that an enzyme crucial to keeping our immune system healthy “surfs” along the strands of DNA inside our cells. The researchers used extremely powerful microscopy to watch how the enzyme AID (activation-induced deoxycytidine deaminase) moves around and interacts with other molecules.

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Article • Bladder

Effectiveness, safety and cost of fluorescence cystoscopy

Bladder cancer is associated with high recurrence rates, necessitating prolonged surveillance and repeated treatments. As a result, it is one of the most challenging and costly of all solid tumours to manage. Although most patients present at an early stage with non-muscle-invasive bladder cancer (NMIBC), between 13% and 61% will experience recurrence within 1 year of initial transurethral…

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News • Lung Metastasis

Subpopulation of white blood cells stands guard

One goal of immunotherapy is to rally a patient’s often over-burdened immune cells to effectively attack a tumor. Among foot soldiers on the immune front line is a subpopulation of white blood cells called “patrolling monocytes,” whose job is to cruise the bloodstream, cart off cellular debris, and block invasion of a less benign population of inflammatory cells.

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News • “JEDI” Technology

New understanding of how immune system works

When it comes to fending off disease and helping prevent people from falling ill, the body’s immune system – armed with T-cells that help eliminate cancer cells, virus-infected cells and more – is second to none. But exactly how the immune system works remains, in many ways, a mystery, as there are numerous cell types whose functions and interactions with our immune systems have not been…

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News • See trough bones

Uncover new details about blood-forming stem cells

A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has become the first to use a tissue-clearing technique to localize a rare stem cell population, in the process cracking open a black box containing detailed information about where blood-forming stem cells are located and how they are maintained. The findings provide a significant advance toward understanding…

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Article • Pathology

Unlocking imaging potential

Automated image analysis shows significant potential within histopathology to help identify novel and subtle prognostic features. UK expert Dr Peter Caie also believes such image analysis can turn aspects of histopathology from a traditionally semi-quantitative field into a fully quantifiable and standardised science. However, he also points out that challenges remain before the full potential is…

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Article • Therapy

Molecular imaging mines deeper

The view across the Atlantic – it fills Professor Fabian Kiessling, Chair of Experimental Molecular Imaging at the RWTH Aachen (Rhine-Westphalia Institute of Technology Aachen), with optimism. The USA offers more opportunities for molecular imaging. Only recently, new tracers for Alzheimer’s were accepted as reimbursable in some centres, whilst the development of new diagnostics in Europe…

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News • Blindness

OCT technology detects blood vessel in the eye

Research published in the Proceedings of the National Academy of Sciences (PNAS) demonstrates that technology invented by researchers at Oregon Health & Science University’s Casey Eye Institute can improve the clinical management of the leading causes of blindness. Optical coherence tomography (OCT) angiography could largely replace current dye-based angiography in the management of these…

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Article • Digital pathology

Biopsy results

Gideon Ho, CEO and co-founder of Singapore-based HistoIndex is confident: ‘After a biopsy a patient waits in a hospital bed, but now, instead of waiting a couple days until doctors know how to treat this patient, we can deliver results while the patient is still in the hospital.’ Report: John Brosky

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Article • Infection Control

POCT accelerates diagnosis of STDs

Trichomonias, with an estimated 187 million cases, and Chlamydia with around 100 million, are the most prevalent sexually transmitted diseases (STDs), according to the World Health Organisation (WHO). There are approximately 36 million cases each of gonorrhoea and syphilis. HIV1/2 cases are around 34 million. Report: Cynthia Keen

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Tiny nanodevice monitors cancer treatment

A tiny nanoscale device can accurately measure a patient’s blood for methotrexate – a commonly used but potentially toxic cancer drug – in under 60 seconds, according to biomedical instrument designer Jean-François Masson, and Joelle Pelletier, a DHFR enzyme specialist, both at the Chemistry Department, University of Montreal.

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Protein test instead of cystoscopy

A recent study from the Heidelberg-based company Sciomics, a spin-off from scientists from the German Cancer Research Center (DKFZ), has presented an advanced method to predict the recurrence of bladder cancer after surgery. The method, which can help avoid frequent cystoscopy examinations in a majority of patients, is based on an analysis of the protein composition of cancer tissue obtained…

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Hygiene: Back to basics

Two statements from publications by Dr Stephanie Dancer, Department of Microbiology, Hairmyres Hospital, East Kilbride (UK) prompted Ralf Mateblowski to interview Professor Markus Dettenkofer, Acting Director of the Institute for Environmental Medicine and Hospital Hygiene, Freiburg University Medical Centre about environmental and infection control

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Fusion and Fly Thru - the new Aplio 500

Catastrophes draw people closer, as demonstrated by the development of the new high-end ultrasound scanner Aplio 500 from Toshiba. The clinical evaluation period took place during the tsunami and the nuclear catastrophe in Fukusima. Professor Thomas Fischer at the Radiological Institute, Charité Clinic in Berlin, was impressed by the enormous commitment shown by the Japanese firm’s engineers…

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EASD 2010 review

7,000 people from 120 countries met in Stockholm this September to hear international experts discuss the progress, solutions and challenges of one of our greatest healthcare burdens. Prevention, self-monitoring, surgery, guidelines, economic problems, drug-safety, and co-morbidities – these are just a few of the problems associated with the care of about 55 million diabetics in Europe.

Molecular imaging

Molecular imaging, the discipline that unites molecular biology and in vivo imaging technologies to assess biological activity in the body, promises to open up ‘…an entire new universe,’ declared Dr Ralph Weissleder, of the Centre for Molecular Imaging Research at Massachusetts General Hospital, USA, in the journal Radiology. That was just one decade ago. And he was right. It has indeed…

Exploring a new universe

Molecular imaging, the discipline that unites molecular biology and in vivo imaging technologies to assess biological activity in the body, promises to open up ‘…an entire new universe,’ declared Dr Ralph Weissleder, of the Centre for Molecular Imaging Research at Massachusetts General Hospital, USA, in the journal Radiology. That was just one decade ago. And he was right. It has indeed…

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Shimadzu combines two vital strengths to create new molecular imaging technologies

Molecular imaging, a new science that emerged from molecular biology, is unlike traditional imaging. Whilst the latter can, for example, show the differences in proton density or water content on MRI, molecular imaging uses biomarkers (probes) that interact selectively with molecules within an area and then generate the image according to fine molecular alterations occurring inside (e.g. within a…

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New Digital Camera for Fluorescence Applications

The detection and documentation of low light fluorescence signals in live cell experiments is a particular challenge for digital cameras. To meet this demand, Leica Microsystems adds the new Leica DFC345 FX to its portfolio of powerful digital cameras. In addition to combining high sensitivity with high resolution, this new camera features a fast image capture rate and a broad dynamic range,…

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A promising new breast cancer test

The Innovation Prize for outstanding, application-oriented ideas in life sciences has been awarded by the Working Group of BioRegions at the Biotechnica in Hanover to research groups from Heidelberg, Munich and Ulm. Professor Lisa Wiesmüller, of the Women’s Hospital, University of Ulm, received the €2,000 prize for developing a test system for the identification and early detection of breast…

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Leading-edge Laser Microdissection Technology

The Leica LMD7000 is the only laser microdissection system with a power adjustable, high precision laser. For the first time, high laser power and high repetition rates, are combined within one system. The laser's high pulse repetition rates are ideal for the fast excision of single cells, cell clusters, or thin and soft samples. Additionally, high laser power allows the dissection of thick or…

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Olympus presents new clinical chemistry systems

Olympus is presenting the AU480, the newest member of its clinical chemistry analyser family. With a throughput of up to 800 tests per hour, an ISE module and on board capacity of 63 different analytes, the Olympus AU480 is the ideal main analyser for small to medium-size laboratories.

On-the-spot multi-task lab-on-a-chip

A new lab-on-chip system, the ivD-platform, which quickly determines, on site, the contents and parameters of biological samples, such as blood or saliva, with the help of immunoassay or DNA analysis, was presented at Biotechnica this autumn.

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New ingredient in paints kills superbugs

Scientists found out that particles of titanium dioxide, which is e.g. contained in the white lines at tennis courts, can kill bacteria and destroy dirt when activated by fluorescent light. Added in paints, the nanotitanium can kill superbugs on all surfaces in hospitals.

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A new imaging system for cancer

Accurate diagnostic analysis and staging of cancer of the bile duct still remains a challenge. According to a new study from Germany a new imaging system called Cellvizio allows physicians to examine tissue at the cellular level from inside the body may now enable them to diagnose one of the most difficult cancers to detect.

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I see diabetes in your eyes

Diabetes fires researchers imagination: Two scientists at the University of Michigan Kellogg Eye Center developed a new screening device that gives early warnings of diabetes and its vision complications within five minutes.

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Britain: The big bug buster

The UK's MRSA rates have been declining since 2006 — and this year could be 50% lower than in 2004. This increasing control over dangerous pathogens has not been achieved without considerable hospital staff efforts, relentless public and government pressures on them, and in-house malcontent about the out-sourcing of cleaning work. Given the cost of nosocomial infections to patients, the NHS…

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Raman spectroscopy improves molecular imaging

A team of Stanford University School of Medicine researchers has developed a new type of imaging system that can illuminate tumors in living subjects-getting pictures with a precision of nearly one-trillionth of a meter.

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Innovations to improve cost and quality of patient care

“We have a broad set of products and services that enable healthcare providers to improve the quality and cost of patient care,” said Carestream Health's Chief Executive Officer Kevin J. Hobert with reference to Carestream´s RSNA highlights. “We have digital technology and consulting services that few companies can match, and our integrated imaging and IT solutions are helping healthcare…

Nanorods of gold blast holes in cancer tumours

USA — Miniscule gold 'nanorods' triggered by a laser beam can blast holes in tumour cell membranes, which then activates a complex biochemical mechanism that leads to the tumour cell to self-destruct, according to researchers at the Weldon School of Biomedical Engineering in Purdue University, Idaho.

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Virtual slide for real analysis

The updated Olympus dotSlide digital virtual microscopy system can scan entire slides at high resolution and fidelity, making them accessible and fully navigable anywhere in the world. Using any of the three models - dotSlide MD (manual); dotSlide SL (fully automated, with slide loader), and dotSlide TMA (with a tissue micro-array module) - users can examine a virtual slide as if seeing the…

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Simplifying precise urinalysis

Sysmex urine fluorescence flow cytometers offer a wide variety of clinical benefits to the user, including determination of WBC, bacteria and yeasts to exclude urinary tract infections and/or inflammations very quickly.

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The Eisenherz project

Tobias Schaeffter PhD, Principal Scientist, Philips Research Laboratories, Hamburg, Arne Hengerer PhD, Director molecular MR, Siemens Medical Solutions, Erlangen, and Andreas Briel PhD, Eisenherz project manager, Schering Research Laboratories, Berlin, describe...

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CTLM Seeing through the dense breast

Optical imaging stands on the threshold of a vast array of imaging uses, writes Professor Eric N C Milne MD FRCR FRCP, Professor Emeritus of Radiology and Medicine, University of California Irvine, and Director of Clinical Research, Imaging Diagnostic Systems Inc. `Presently, its greatest worth lies in higher sensitivity for the dense breast. It detects many more occult cancers than conventional…

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