Photo:

Clinicial chemistry

Clinical chemistry has evolved far beyond its beginnings of blood and urine analysis. Advanced techniques such as enzyme measurement, electrophoresis, and immunoassays have made their impact on the field, expanding its diagnostic capabilities. Keep reading for advances in automation and clinical chemistry applications for toxicology, urinalysis and much more.

Photo

News • Dynamic network analysis

AI unlocks new path to personalized cancer treatments

A US-Swiss team leverages AI and molecular simulations to uncover new pathways for precision cancer treatments, paving the way for more effective, personalized therapies.

Photo

News • Glycopeptide probes for antibody detection

New method speeds up pancreatic cancer detection

A new method could lead to a significantly more precise and reliable diagnosis of pancreatic cancer. It is based on the selective detection of specific antibodies in blood samples.

Photo

News • Improving Alzheimer’s disease imaging

Diagnostic sensors overcome blood-brain barrier

Researchers were able to package fluorescent sensors for passage across the blood-brain barrier (BBB) in mice. This holds promise to advance Alzheimer’s disease diagnosis and treatment.

Photo

News • Fluorescence assay

A 'FAIRY' to rapidly determine virus infectivity

Researchers have developed a fluorescence assay for viral integrity (or FAIRY, for short), to quickly determine the effectiveness of countermeasures against a given virus.

Photo

News • Integration of microanalysis chips

Establishing microfluidic control technology for blood testing devices

A research group established a microfluidic control technology that can be applied to small blood testing devices and consequently developed a novel integrated immunoassay device.

Photo

News • Cortisol sampling from blood

Paving the way for better diagnosis and treatment of endocrine diseases

A team of researchers has discovered a new method of measuring levels of cortisol directly from a blood sample - a significant step forward in diagnosis and treatment of a wide range of diseases.

Photo

Article • Overheard at AACC

The complexities of drug testing in urine and hair

Urine screening tests using only immunoassays are the most common procedures used to identify drug abuse. They are inexpensive, automated, and produce rapid results. But they may generate false-positive or false-negative results, which vary based on the drug, drug class, and the assay used. Hair toxicology analysis is another form of drug testing which, unlike urine tests, enable analysis of drug…

Photo

Article • Preventing clinical errors

Supporting transgender health in the clinical laboratory

Clinical laboratories need to be proactive to attract transgender patients for testing and to ensure that they are comfortable with the services provided. This issue is of great importance to the American Association for Clinical Chemistry (AACC), which conducted a scientific session on transgender health at its recent annual meeting in Chicago.

Photo

Article • Exploring the potential of IMS

Ion mobility spectrometry: Rapid results from breath analysis

Ion-mobility spectrometry (IMS) offers opportunities for rapid diagnosis and clinical decision-making due to breath analysis. As a rapid separation tool, it has clinical value in the identification and analysis of proteins, peptides, lipids, and glycans. The tool is already used as an exhaled drug monitor for anaesthetised patients. It is flexible, portable and has use for point-of-care testing,…

Photo

Article • Detecting Coronavirus

AI vs. Covid-19: ‘Barcode’ brings quicker test results

When patients are admitted to a hospital emergency room (ER) it is immediately vital to determine whether s/he has Covid-19. However, with a regular PCR test a result can take up to a few hours. Thus, initially, the patient must be isolated. During the height of the corona pandemic last year, researcher Ruben Deneer from Eindhoven University of Technology (TU/e) and clinical chemist Arjen-Kars…

Photo

Article • Personalised medicine

'Body-on-a-chip' technology boosts drug development

Integrating laboratory functions on a microchip circuit is helping improve the cost-effectiveness of drug development. So-called ‘lab-on-a-chip’ or ‘human-on-a-chip’ technology can highlight which treatments may, or may not, work before advancing along the clinical trial process. It can also have benefits for chronic and rare diseases, as well as helping shape personalised medicine.…

Photo

News • SARS-CoV-2 medication

Remdesivir: additional mechanism against Covid-19 discovered

When a cell is infected, SARS-CoV-2 not only causes the host cell to produce new virus particles. The virus also suppresses host cell defence mechanisms. The virus protein nsP3 plays a central role in this. Using structural analyses, researchers at Goethe University in cooperation with the Swiss Paul Scherrer Institute have now discovered that a decomposition product of the virostatic agent…

Photo

News • Potential for rapid, accurate glycan sequencing

Enormous boost for sequencing key molecules

Using a nanopore, researchers have demonstrated the potential to reduce the time required for sequencing a glycosaminoglycan — a class of long chain-linked sugar molecules as important to our biology as DNA — from years to minutes. Research to be published this week in the Proceedings of the National Academies of Sciences shows that machine-learning and image recognition software could be…

57 show more articles
Subscribe to Newsletter