Keyword: personalised medicine

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"Alliance for Precision Health”

Missouri University partners up with Siemens

Siemens Healthineers, University of Missouri System (UM System) and University of Missouri Health Care (MU Health Care) launch "Alliance for Precision Health.” The ten-year collaboration will bring the partners’ expertise together to improve health care in Missouri State, promote education and launch research initiatives. Among other things, the clinic receives the only 7 Tesla MRI…

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Flow cytometry

Living cells – the essential biomarker

The team of the Heinz Nixdorf Chair of Biomedical Electronics at the Technical University of Munich focuses on innovative diagnostic tools to accelerate the development towards personalized medicine. Therapies tailored to the individual patient – this is the future not only of oncology but of many medical disciplines. “At this point, however,” concedes Professor Dr Oliver Hayden,…

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Personalized treatment

Genome analytics become affordable for daily hospital use

Today, on the occasion of the international DNA day, imec, a world-leading research and innovation hub in nanoelectronics and digital technologies, and its partners revealed their Genome Analytics Platform (GAP) platform, a unique platform that can perform a full genome analysis of 48 samples in only 48 hours and at an acceptable cost. The platform paves the way to genome sequencing as a daily…

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Post-analytical interpretive tools

Towards a clearer view of complex lab results

Interpretation of complex profiles of laboratory results can be significantly improved via multivariate pattern recognition software. A multivariate pattern recognition software, developed by a team led by Dr Piero Rinaldo at Mayo Clinic in Rochester, USA, aims to integrate results to diagnose a particular condition in a single score, in an objective evidence-based way that is open to worldwide…

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Digital pathology & AI

Unleashing the power of digital pathology for precision medicine

Digital pathology, combined with the power of Artificial Intelligence (AI), is one of the most promising fields for the delivery of precision medicine. In the first keynote address for the 5th Digital Pathology & AI Congress (Europe) held in London last December, Professor of Pathology, Marilyn Bui, focused on how digital pathology is impacting on precision medicine. During her address,…

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Targeted treatment

Cancer: Blood sample to help select the right early phase clinical trials

Scientists could help match cancer patients with no other treatment options to clinical trials with experimental medicines, by analysing the genetic faults in a sample of their blood. The researchers, funded by Cancer Research UK, The Christie Charity, AstraZeneca and the NIHR Manchester Biomedical Research Centre (BRC), demonstrated in their feasibility study that a blood test can be carried out…

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Biotechnology

First ever 3D printed heart from a patient’s own cells

In a major medical breakthrough, Tel Aviv University researchers have "printed" the world's first 3D vascularised engineered heart using a patient's own cells and biological materials. Until now, scientists in regenerative medicine — a field positioned at the crossroads of biology and technology — have been successful in printing only simple tissues without blood vessels. "This…

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Personalized medicine

FDA approves first targeted therapy for metastatic bladder cancer

The U.S. Food and Drug Administration (FDA) granted accelerated approval to Balversa (erdafitinib), a treatment for adult patients with locally advanced or metastatic bladder cancer that has a type of susceptible genetic alteration known as FGFR3 or FGFR2, and that has progressed during or following prior platinum-containing chemotherapy. Patients should be selected for therapy with Balversa…

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Accuracy improvement

Predicting prostate cancer with radiomics and machine learning

A team of researchers from the Icahn School of Medicine at Mount Sinai and Keck School of Medicine at the University of Southern California (USC) have developed a novel machine-learning framework that distinguishes between low- and high-risk prostate cancer with more precision than ever before. The framework, described in a Scientific Reports paper, is intended to help physicians—in particular,…

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Time for a revolution?

About the end of medicine, as we know it

Currently many researchers and experts assume that the next great socio-economic revolution will include a completely new definition of health and how we define illnesses and therapies. “Our health system today can no longer be sustained in its existing form. It has become too expensive and too ineffective,” Professor Harald Schmidt, head of the Department of Pharmacology and Personalised…

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Precision medicine

Europe looks to cells for a healthier future

How can we detect the first signs of disease as early as possible? Could closer investigation at the cellular level help to quickly prevent disease progression through appropriate treatment? The European Union is now investing a million euros over a one-year period to devise the plan for a fundamentally new approach to understanding the constant changes within cells and their relationships to one…

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Getting personal(ised)

Pathology: Moving us towards precision medicine

The European Society of Pathology (ESP) holds its European Congress of Pathology (ECP) at different venues annually. This year, in Spain, 3,448 delegates from 87 countries attended. There, ESP president Dina Tiniakos spoke about the increasing role of pathology in precision medicine including challenges linked to digitisation. ‘Precision medicine is the centre-point for cancer management, but…

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Oncology

COMPASS: The guide to new therapies for children with cancer

Through a targeted combination of molecular and microscopy-based techniques, researchers aim to identify new treatment approaches for children with cancer. The Hopp Children's Cancer Center Heidelberg (KiTZ) coordinates the project, which is funded by the European consortium ERA PerMed with 1.5 million euros and involves scientific institutions from France, the Netherlands, Finland and Hungary in…

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Glioblastoma

New actively personalized therapeutic vaccine for brain cancer

The prospect of an actively personalized approach to the treatment of glioblastoma has moved a step closer with the recent publication in Nature of favorable data from the phase 1 study GAPVAC-101, testing a novel therapeutic concept tailored to specific characteristics of patients’ individual tumors and immune systems. For the first time, the feasibility of such a highly personalized form of…

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Innovation

AI helpers simplify clinical MRI scans

The new 1.5 Tesla MRI from Siemens Healthineers, Magnetom Sola, is packed with helpful algorithms and other functions. AI-supported systems monitor patients and scan parameters and ensure consistent image quality. Whilst visitors at this year’s ECR-Expo admired the new device, Prof. Ulrike Attenberger has already tested it in practice. The Vice Chair at the Institute of Clinical Radiology and…

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Precision CV medicine

New biomarkers for cardiovascular disease

A range of new biomarkers and diagnostics for precision cardiovascular medicine were outlined in a session at the British Cardiovascular Society annual conference held recently in Manchester. Speakers from King’s British Heart Foundation Centre looked at how mass spectrometry allows clinicians to measure large numbers of proteins simultaneously, discussed a new biomarker for cardiac ischaemia…

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Promising research

First steps towards a new, targeted lung cancer treatment

Scientists have identified a key molecular player in a subtype of lung cancer which could lead to a new way to tackle the disease, according to research published in Nature Communications. They found lung squamous cell carcinoma (LUSC) cells contained high amounts of a protein called BCL11A. The study showed that manipulating the gene responsible for the protein stopped the development of LUSC in…

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Personalised drug treatment

AI approach to help myeloma patients

A multidisciplinary team of researchers from the National University of Singapore (NUS) has developed an artificial intelligence (AI) technology platform that could potentially change the way drug combinations are being designed, hence enabling doctors to determine the most effective drug combination for a patient quickly. Applying the platform towards drug resistant multiple myeloma, a type of…

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Gaining ground

MRI advances approach the realm of precision medicine

MRI has developed rapidly over the past decade in Poland, where clinicians are combining MRI with PET and CT to highlight tumour growth or regression and perfusion. ‘The fact that MRI offers new software and programmes means we can diagnose pathologies more precisely and make a diagnosis faster than a few years ago,’ explained Poland’s national advisor on radiology and diagnostic imaging…

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Precision medicine

Promising radiomics for breast MRI

‘Breast cancer rates are continuously increasing, and we don’t yet have a means of prevention,’ said Dr Clemens Kaiser, from the Medical Faculty Mannheim, at Heidelberg University, who believes the only way to save more patients from death, after providing the best possible diagnostics procedures, is via precision medicine: the right treatment at the earliest possible time. The radiologist…

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Innovation

Siemens Healthineers debuts new thermocycler and AI-powered interpretation software

At the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Fast Track Diagnostics, a Siemens Healthineers company, launches a new molecular thermocycler, the Fast Track cycler, and the complementary new FastFinder software. The Fast Track cycler is a compact platform that enables laboratories of all sizes to implement molecular testing with simplicity and speed…

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New report

Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening

A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for…

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Personalized medication

An edible QR code might be the pill of the future

Researchers at the University of Copenhagen have developed a new method for the production of medicine. They print medical drugs in QR coded patterns onto an edible material. The production can be tailored to fit each patient and has the potential to protect against wrong medication and fake medicine according to the researchers. For the last 100 years, researchers have constantly pushed the…

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