Pain

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News • Chronic inflammatory disease

"Frozen shoulder" holds key to understanding fibrosis resolution

Researchers have identified how cells work to resolve "frozen shoulder", a painful and disabling condition affecting the ligaments that form the shoulder joint capsule.

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News • New assessment method

AI system could help detect patients’ pain before, during and after surgery

An automated pain recognition system using artificial intelligence (AI) holds promise as an unbiased method to detect pain in patients before, during and after surgery.

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News • New insights into genetic markers

Pregnancy can be a 'miracle cure' for rheumatoid arthritis – but why?

When a woman becomes pregnant, sometimes her pre-existing rheumatoid arthritis will 'magically' go away. In others, the condition becomes even worse. Now, US researchers may have found an explanation.

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News • Q&A on research, diagnosis, treatment

Endometriosis: More than just ‘painful periods’

Endometriosis, which can cause debilitating pain each menstrual cycle, as well as infertility, is often misdiagnosed and misunderstood. An expert from Yale Medicine sheds light on the condition.

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News • Women's health

Cadmium levels in urine linked to endometriosis

Women with a history of endometriosis had higher concentrations of cadmium in their urine compared to those without that diagnosis, a new study finds, linking the toxic metal to the condition.

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News • UK research findings

Digital health tools could prevent hundreds of thousands A&E admissions

UK researchers find that digital health products, e.g. health apps, could make a substantial contribution to tackling NHS urgent care pressures, by keeping patients out of hospital in the first place.

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News • 3D microelectrodes

Promising approach for pain relief without side effects

Researchers at Lund University in Sweden have developed a completely new stimulation method, using ultra-thin microelectrodes, to combat severe pain. This provides effective and personalised pain relief without the common side effects from pain relief drugs. The study, which was conducted on rats, has been published in the research journal Science Advances.

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News • Headache

Chronic migraine: potential novel treatment discovered

By discovering a potential new cellular mechanism for migraines, researchers may have also found a new way to treat chronic migraine. Amynah Pradhan, associate professor of psychiatry at the University of Illinois Chicago, is the senior author of the study, whose goal was to identify a new mechanism of chronic migraine, and propose a cellular pathway for migraine therapies. The study, “Neuronal…

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News • Osteoarthritis research

New treatment target could halt knee cartilage degeneration

There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that…

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News • Sex bias

Is pain research turning a blind eye on women?

Females process pain differently, but search for pain medication still based on hypotheses drawn from work in males, a study from Canada finds. It is increasingly clear that male and female humans and rodents process pain in different ways. And that there are important differences in the underlying mechanisms involved at genetic, molecular, cellular, and physiological levels. Despite this fact,…

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News • When painkillers won't help

A new approach to pancreas pain treatment

One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the…

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News • In the skin

New 'pain organ' discovered

Researchers at Karolinska Institutet in Sweden have discovered a new sensory receptor organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the scientific journal Science. Pain causes suffering and results in substantial costs for society. Almost one person in every five experiences constant pain and there is a considerable need to…

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News • Women's health

Endometriosis: Antibiotic could be key to treatment

Researchers at Washington University School of Medicine in St. Louis have found, in mice, that treatment with an antibiotic reduces the size of lesions caused by endometriosis. The researchers are planning a large, multicenter clinical trial to test the drug metronidazole in women who have the painful condition. The study is published online April 30 in the journal Human Reproduction.…

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