Through a targeted combination of molecular and microscopy-based techniques, researchers aim to identify new treatment approaches for children with cancer. The Hopp Children's Cancer Center Heidelberg (KiTZ) coordinates the project, which is funded by the European consortium ERA PerMed with 1.5 million euros and involves scientific institutions from France, the Netherlands, Finland and Hungary in…
A team of University of Illinois at Urbana-Champaign researchers led by Bioengineering Professor Stephen Boppart has successfully visualized the tumor microenvironment of human breast tissue shortly after it was surgically removed from a patient in the operating room. The researchers achieved this using a new portable optical imaging system developed in Boppart's lab.
Measuring tumour infiltrating lymphocytes (TILs) is gaining importance in immunotherapy, but other variables must also be considered to boost prognosis and prediction accuracy, a leading pathologist argued at EBCC 11 last March in Barcelona. When it comes to prognosis and prediction for immunotherapy, a potentially new variable is emerging – TILs – white blood cells that have left the blood…
Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely…
A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers. The new understanding of the mechanism that allows citrate to aid in bone regeneration will help the researchers develop slow-release, biodegradable citrate-releasing scaffolds to act as bone-growth…
Mariette Barbier, an assistant professor in the West Virginia University School of Medicine, and her research team are investigating ways to keep cystic fibrosis patients and other at-risk populations—including patients hospitalized for severe burns or recovering from major surgery—from catching this deadly illness.
New accelerator-based technology being developed by the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University aims to reduce the side effects of cancer radiation therapy by shrinking its duration from minutes to under a second. Built into future compact medical devices, technology developed for high-energy physics could also help make radiation therapy more…
Built as the first commercially available scanner to deliver truly digital PET, the Vereos PET/CT, from Philips, offers revolutionary Digital Photon Counting technology. The science behind this scanner evolution is ‘quite complicated’, agrees Piotr Maniawski, Director of Clinical Science Nuclear Medicine at Philips Healthcare, yet the improved performance is significant, particularly when…
Research on a bacterial toxin first discovered in Adelaide has led to the development a new blood test for the early diagnosis of ovarian cancer - a disease which kills around 150,000 women globally each year.
Using technology similar to the type that powers facial and speech recognition on a smartphone, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have trained a computer to analyze breast cancer images and then classify the tumors with high accuracy. In a study published in the journal NPJ Breast Cancer, researchers reported they used a form of artificial…
The selection of a first-line chemotherapy drug to treat many types of cancer is often a clear-cut decision governed by standard-of-care protocols, but what drug should be used next if the first one fails? That’s where Georgia Institute of Technology researchers believe their new open source decision support tool could come in. Using machine learning to analyze RNA expression tied to…
It is non-invasive, delivers a chance of early diagnosis, prognostic information and sequential monitoring, and, believes Professor Francesco Salvatore, the enormous potential of liquid biopsies has still to be reached. However, the positive results obtained so far have ‘opened the door to a promising new multi-faceted group of tumour markers, at present collectively designated “liquid…
A research team led by the University of Alabama at Birmingham is launching a study to find a better model for glioblastoma, a particularly devastating type of brain tumour, to help determine the most appropriate treatment modality. The $3.6 million, five-year U01 grant award is funded by the National Cancer Institute, one of the National Institutes of Health. The UAB team will join four other…
A pathology test that applies artificial intelligence (AI) to characterize tissue samples can accurately predict clinically significant prostate cancer disease progression following surgery, according to a study conducted at the Icahn School of Medicine at Mount Sinai.
Women diagnosed with non-small cell lung cancers (NSCLC) live longer than their male counterparts, according to results of a SWOG study presented by Loyola Medicine researcher Kathy Albain, MD, at the International Association for the Study of Lung Cancer's 19th World Conference on Lung Cancer in Toronto.
A research team led by Arun Iyer, Ph.D., assistant professor of pharmaceutical sciences in the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University, has developed a nanoplatform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma.
With new immunotherapy treatments for melanoma, recovery rates have risen dramatically – in some cases to around 50%. But they could be much higher. A new study led by researchers at the Weizmann Institute of Science showed, in lab dishes and animal studies, that a highly personalized approach could help the immune cells improve their ability to recognize the cancer and kill it.
Pancreatic cancer is currently very difficult to detect while it is still resectable. A new blood test developed by researchers at Lund University in Sweden, Herlev Hospital, Knight Cancer Center and Immunovia AB, can detect pancreatic cancer in the very earliest stages of the disease.
Cancer cells often have mutations in their DNA that can give scientists clues about how the cancer started or which treatment may be most effective. Finding these mutations can be difficult, but a new method may offer more complete, comprehensive results. A team of researchers has developed a new framework that can combine three existing methods of finding these large mutations - or structural…
In healthy individuals, the Zika virus causes flu-like symptoms. If a pregnant woman becomes infected, the unborn child can suffer from severe brain abnormalities as a result of mechanisms that have not yet been explained. A study by the Technical University of Munich (TUM) and the Max Planck Institute of Biochemistry (MPI-B) shows that Zika virus proteins bind to cellular proteins that are…
Changes in circulating tumor DNA levels quickly predict how patients with diffuse large B cell lymphoma are responding to therapy, according to a Stanford-led study. Currently, patients wait months for the results.
A pioneering study into myeloma, a rare cancer, could lead to General Practicianer (GPs) using simple blood tests to improve early diagnosis. The study investigated the best combination of blood tests that could be used to diagnose myeloma in GP practices.
Using a new approach called 'reinforced learning', researchers have taught an artificial intelligence (AI) to responsibly choose the right amount of chemo- and radiotherapy for glioblastoma patients. The technique, which is insprired by behavioural psychology, has given the AI the ability to master the tightrope walk between effective tumor shrinkage and the medications' severe side effects.
Monash University’s Biomedicine Discovery Institute (BDI) researchers have identified a new mechanism used by Henipaviruses in infection, and potential new targets for antivirals to treat them. Their findings may also apply to other dangerous viruses.
A new augmented reality system to guide procedures in interventional oncology is currently taking its first steps. A three-step experiment proves this system to be precise and reliable enough to facilitate image guidance critical to the success of interventional oncology procedures. Using a back-face camera and a tablet PC to visualise the patient, the system projects 3D images of body structures…