Tumor growth
New insights into colorectal cancer
Researchers have found a surprising effect of the stem cell-regulating growth factor R-spondin in intestinal cancer.
#oncology
Digitising healthcare
Virtual assistants and digital twins advance personalised medicine
Siri and Alexa are leading the way: the virtual assistants meet many daily needs. Soon, similarly programmed software and a ‘digital patient twin’, will be launched into the medical world – both IT applications based on Artificial Intelligence (AI). The virtual medical assistant and digital patient twin are two key aspects of a research project ‘Models for Personalised Medicine’.…
Neuro-oncology
Challenges in brain tumour segmentation
Neuroradiologist Dr Sofie Van Cauter described the challenges to brain tumour image segmentation during the European Society of Medical Imaging Informatics (EuSoMII) annual meeting in Valencia. She also outlined how, when clinically validated, AI could help tackle such problems. The WHO classification of brain tumours has come a long way since first introduced in 1979. The 2016 classification was…
Theranostics
Magnetic gold nanohybrid particles will help fight cancer
A team of scientists at the Russian National University of Science and Technology MISiS, together with colleagues from Russia and Germany, have presented a detailed study of magnetite-gold nanohybrids. In the future, such nanoparticles can help in theranostics — the diagnostics and subsequent therapy of oncological diseases. The results of the work have been published in the Journal of…
Cervical cancer
3D imaging system accelerates cancer diagnosis
Researchers have developed a novel three-dimensional imaging system to diagnose cervical cancer faster, non-invasively and more efficiently than conventional methods.
Oncology
How cancer spreads in blood
A new study sheds light on proteins in particles called extracellular vesicles, which are released by tumor cells into the bloodstream and promote the spread of cancer. The findings suggest how a blood test involving these vesicles might be used to diagnose cancer in the future, avoiding the need for invasive surgical biopsies.
Viral oncology
Kaposi Sarcoma: Answers to a longstanding enigma
The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi’s Sarcoma. An international team of scientists led by the University of Helsinki has discovered key factors that control the genome maintenance and replication of a virus responsible for lymphatic vascular cancer. Kaposi Sarcoma (KS) is the most common cancer among Aids patients and it is often seen in sub Saharan and…
Oncology breakthrough
Blood test detects 50+ cancer types, often before symptoms show
Researchers have developed the first blood test that can accurately detect more than 50 types of cancer and identify in which tissue the cancer originated, often before there are any clinical signs or symptoms of the disease. In a paper published in the leading cancer journal Annals of Oncology, the researchers show that the test, which could eventually be used in national cancer screening…
Triple-negative forms impeded
Scientists stop breast cancer cells from spreading in the lab
Biologists have discovered a way to stop cells from one of the most aggressive types of breast cancer spreading in the lab. The study points towards new avenues of research to combat the devastating disease. The results of the study of Triple-Negative Breast Cancer by the team from the Universities of Manchester, Glasgow and Sheffield and funded by Breast Cancer Now are published in Oncogene.…
The future has begun
Cancer care 2035: multi-disciplinarity is key
An enthralling insight into the care that could be offered to cancer patients of the future was presented by cancer imaging expert Professor Regina Beets-Tan during her a keynote presentation at the recent British Institute of Radiology congress. In the session ‘Oncologic imaging: Future perspectives’, the professor outlined what a Multi-Disciplinary Team (MDT) of the future – a team in…
The search is on
MRI contrast agents: Aiming to work without radioactivity
MRI is now indispensable for diagnosing diseases and monitoring therapies. However, the ongoing discussion on gadolinium deposits in the brain has intensified the search for alternatives. Dr Daniel Paech of the German Cancer Research Centre in Heidelberg, Germany, discussed potential solutions to acquire high-quality images without contrast agents.
Personalized diagnostics
AI checks effectiveness of immunotherapy
Scientists from the Case Western Reserve University digital imaging lab use Artificial Intelligence (AI) to predict which lung-cancer patients will benefit from expensive immunotherapy. This is done by teaching a computer to find previously unseen changes in patterns in CT scans taken when the lung cancer is first diagnosed compared to scans taken after the first 2-3 cycles of immunotherapy…
Breast cancer
Giving patients an average survival time is more often wrong than right
Doctors who give advanced breast cancer patients just one estimate, such as 12 months, for the average amount of time they are expected to live are only accurate 20-30% of the time, according to Dr Belinda Kiely, medical oncologist and senior research fellow at the University of Sydney, Australia.
Lung cancer early diagnosis
Can we afford not to offer lung screening?
For lung cancer patients, life expectancy has hardly improved since 1970. A ten-year survival is 5%, making this the leading cause of death among all cancers. One reason is that, in most cases, the disease is diagnosed far too late. Professor Mathias Prokop is among leading advocates of low-dose CT screening for lung cancer for high risk patients.
Cancer
Researchers develop tumour growth roadmap
Researchers at Leipzig University and Leipzig University Hospital (UKL) have discovered that tumour growth and tissue invasion by cancer cells can be predicted based on the ontogenetic distance between tissues.
Imaging
Photoacoustic technology could 'revolutionize' cancer surgery
Cancer treatment could be dramatically improved by an invention at the University of Waterloo to precisely locate the edges of tumors during surgery to remove them.
Watson on the case
Personalised cancer care through AI
The Geneva University Hospitals (HUG) is the first European university hospital to utilize IBM’s artificial intelligence (AI) technology to help uncover therapeutic options for cancer patients. HUG will use the IBM Watson Health’s precision oncology offering, Watson for Genomics, an AI tool that enables oncologists to provide patients with more personalized, evidence-based cancer care. Using…
Methods, quality assurance, commercial providers issues
Molecular testing takes a huge leap
In terms of success in revolutionary cancer treatment, molecular genetic examination procedures have developed immensely over recent years. They now range from conventional polymerase chain reactions (PCR) or fluorescence-in-situ hybridisation (FISH) to Next Generation Sequencing (NGS) with analysis of the entire exome or genome (Whole-Exome, WES or Whole-Genome, WGS) and of the transcriptome…
Cancer research
Regina Beets-Tan boards 'Horizon Europe'
Professor Regina Beets-Tan has been appointed to the mission board of the EU research mission on cancer, part of the European Commission’s research initiative known as Horizon Europe. She has been selected to serve on the 15-member board for the cancer mission, tasked with shaping their mission and further defining what research receives funding within the cancer mission’s mandate, beginning…
Therapy-resistant cells
Von Hippel-Lindau: How to kill hereditary cancer
Researchers identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau hereditary cancer. In a recent publication in PNAS, the research group identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau (VHL) hereditary cancer.
Imaging
PSMA PET/CT beats standard scan at prostate cancer detecting
Prostate-specific membrane antigen imaging should be the positron emission tomography imaging agent of choice for men who have a prostate cancer recurrence after radical prostatectomy, which needs to be detected and located. For these men, it should become the standard of care, new research shows.
Cancer care
Oncology Nursing: Worldwide knowledge differs greatly
Nurses’ knowledge of cancer and screening processes varies significantly across the globe – potentially resulting in unnecessary deaths where knowledge falls short – new research reports. In the first study of its kind, which was now published in the European Journal of Oncology Nursing, researchers from the University of Surrey investigated nurses’ awareness of cancer warning signs,…
Oncology
Response to gene-targeted drugs depends on cancer type
Cancers with the same genetic weaknesses respond differently to targeted drugs depending on the tumour type of the patient, new research reveals. The study is set to prompt changes in thinking around precision medicine—because it shows that the genetics of a patient's cancer may not always be enough to tell whether it will respond to a treatment. The researchers are already starting to design…
Boosting our immune surveillance
Antibodies PD-1 and PD-L1: a quantum leap in cancer therapy
Immuno-oncology is a therapy in which the body’s immune system treats a tumour. Dr Eric Borges, from the Research and Development Centre at Boehringer Ingelheim Pharma GmbH in Germany, explains why this is revolutionary. Unlike conventional cancer therapies, with immuno-oncology the tumour cell is not the direct target, it’s the patient’s immune system. The medication stimulates this to…
Oncology
Anti-inflammation approach shows promise for preventing cancer metastasis
An anti-inflammatory drug called ketorolac, given before surgery, can promote long-term survival in animal models of cancer metastasis, a team of scientists has found. Furthermore, so-called "pro-resolution" therapies can also trigger the immune system to eliminate metastatic cells. The research also suggests that flanking chemotherapy with anti-inflammatory drugs can unleash anti-tumor…