Metastases

News • Tumour movement across tissues

Understanding metastasis: migration strategies of ovarian cancer

A new study shows how inherent variations in a cancer cell and its interactions with its surroundings mould its migration. The findings provide valuable insights into the processes behind metastasis.

News • Insights into tumor biology

Breast cancer: Exploring metastasis diversity

In many cases, metastatic breast cancer is still incurable. To improve the odds, researchers have now analyzed the diversity of metastatic cells and their interactions with their cellular environment.

Video • Cancer research

3D-printed tumor model reveals metastasis mechanisms

New insights into metastasis: Scientists created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells. This could help discover new screening and treatment options.

News • Promising study results

Cancer of Unknown Primary: on the way to targeted therapies

Metastases, but no sign of the original tumor: A large international study shows how this phantom cancer can nevertheless be treated.

News • Focus on ferroptosis

Major step towards a treatment for metastasis

Researchers have discovered an Achilles heel of migratory metastatic cells: They now investigate how the cell death mechanism ferroptosis can be utilized for future cancer treatments.

News • Circulating tumor extracellular vesicles

Metastatic prostate cancer: better monitoring with new liquid biopsy method

A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.

News • Research on physical conditions

Exploring the link between obesity and cancer risk

Why does obesity increase the risk of cancer and possibly metastasis? Researchers in Spain are currently investigating this very question.

News • Research on biomechanics

Tumour 'softness' can drive aggressiveness of breast cancer

Researchers have discovered how the mechanical properties of tumours - their softness, for example - can prime cancer cells to better survive their spread to other organs.

News • Microbial influence on treatment

Study explores the role of bacteria in cancer

Bacteria can help – or hinder – the treatment of cancer. How this happens, however, is largely unknown. Now, researchers have mapped bacteria in cancer metastases to shed more light on their role.

News • Omitting axillary lymph node removal

Breast cancer trial explores benefits of less extensive surgery

A new trial could pave the way for more gentle surgery of breast cancer: The researchers explore the possibility of sparing the lymph nodes in the armpit - even if metastases are already present.

News • Accurate detection and removal

Radioguided surgery to treat metastatic lymph nodes in prostate cancer

Dutch researchers use PSMA targeting to improve detection of prostate cancer, improving nodal staging and guiding more accurate surgery for this important patient population.

News • Metastasis susceptibility

How chronic stress spreads cancer

Chronic stress can have a significant impact on health, from an increased risk for heart disease to a greater susceptibility of cancer metastasis. New research points out the underlying mechanisms.

News • Imaging signatures

CT-based radiomics deep learning to predict lymph node metastasis in tumors

With a combination of radiomics and deep learning, researchers aim to noninvasively determine lymph node metastasis before surgery. This could lead to more accurate diagnosis and treatment strategies.

News • Friend and foe in one

Breast cancer: The paradoxical role of white blood cells

White blood cells found in breast tumors can both help and hinder the spread of cancer cells to other organs, a new study from Karolinska Institutet shows.

News • RENACER repository

Brain cancer tissue samples to gain new insights

A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.

News • Breakthrough against metastatic mammacarcinoma

New approach busts chemo resistance of TNBC breast cancer

A team of researchers from Vienna has discovered that dormant breast cancer tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein.

News • New imaging agent

HER2-positive breast cancer: Whole-body PET/CT predicts targeted therapy response

A new imaging agent can predict early metabolic response to HER2-targeted treatment in metastatic breast cancer patients, according to new research published in the Journal of Nuclear Medicine.

News • Detecting tumors and metastases

Nanoparticles deliver double strike against cancer

A new nanocomplex renders a tumor harmless – and, on top of that, it trains the immune system to detect and eliminate metastases.

News • Research on lymph node infiltration

Metastasis: Understanding breast cancer’s "Trojan horse"

Researchers have unveiled a key mechanism of breast cancer cells to infiltrate lymph nodes. The discovery may lead to new metastasis-blocking treatments and improve patients’ lives.

News • Astrocyte research

New insight into how cancer metastasizes to the brain

A new US-led study shows that astrocyte brain cells play an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

News • Oncology & Cancer

Research uncovers alternate mechanism for producing key protein in metastatic prostate cancer

Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient's metastatic prostate cancer.

News • Optional treatment

Radiotherapy: no benefits for older patients with early breast cancer

Radiotherapy does not improve survival rates in older patients with early breast cancer, new research suggests.

Article • Radioembolization

Breast cancer metastasis: benefits and limitations of trans-arterial therapy

Evidence that radioembolization, a trans-arterial therapy, is safe and stops disease progression in metastatic breast cancer is increasing, a prominent American interventional radiologist showed at the Spectrum conference in Miami.

News • Systems biology

Lung cancer: new discovery could remove metastatic traits

A Korean research team successfully changed the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

News • Primary tumor or metastasis?

Deep learning and radiomics for precise differentiation in brain tumors

The distinction between primary tumors and metastases can be made quickly and accurately in brain tumors using radiomics and deep learning algorithms, a new study shows.

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