Keyword: diabetes

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Boosting the microbiome

A vaccine against chronic inflammatory diseases

In animals, a vaccine modifying the composition and function of the gut microbiota provides protection against the onset of chronic inflammatory bowel diseases and certain metabolic disorders, such as diabetes and obesity. This research was conducted by the team of Benoît Chassaing, Inserm researcher at Institut Cochin (Inserm/CNRS/Université de Paris), whose initial findings have been…

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Subgroup detected

A new Diabetes classification?

The traditional classification of diabetes, mainly in type 1 and type 2 diabetes, has been challenged by studies from Scandinavia. In the current issue of The Lancet Diabetes & Endocrinology, researchers from DDZ together with colleagues from DZD and University of Lund published a cluster analysis of diabetes allowing for phenotyping into subgroups, which extended the findings by showing that…

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Dysbiosis treatment

New prebiotics: benefits without downsides?

Prebiotics are currently a preferred treatment for certain metabolic disorders, as they can restore the balance of dysfunctional gut microbiota, and improve the body’s metabolism. However, these substances have to be used at high doses, which can result in patients experiencing bloating and flatulence. A research group led by Matteo Serino, Inserm researcher at the Digestive Health Research…

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Obesity and Type 1 diabetes

Robotic pancreas transplant offers hope

For patients with Type 1 diabetes who don’t respond well to insulin or have other serious medical complications caused by their disease, pancreas transplantation offers hope for a cure. But obese candidates who need a pancreas transplant often are denied the procedure because of poor outcomes, including high rates of incision infections, which are linked to an increased risk for failure and…

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Cost-effective telemedical eye screening

Smartphones save sight

About one in ten people in southern India is diabetic. Around one in three suffers from a so-called diabetic retinopathy (DR), a disease of the retina caused by diabetes. Untreated, DR is often the cause of visual impairment and blindness. However, many of those affected have symptoms only in the late stages of the disease. Early detection is therefore all the more important in order to intervene…

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Intervention in fat metabolism

Improved diabetes in spite of obesity

Eating too much fat and sugar makes you overweight and unhealthy – even young children know that. But why is that, and is there anything we can do about it? In a study published in the journal Cell, Prof. Jens Brüning's research group at the Max Planck Institute for Metabolism Research in Cologne has shown how altering fat metabolism in the liver can make obese mice thinner, despite eating an…

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Meeting of the generations

We need a Senior Laboratory

It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results. Professor Kai Gutensohn, Managing Director and Medical Director of AescuLabor…

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Stop progression

Weight loss sets back Type 2 diabetes for at least two years

More than a third of people with Type 2 diabetes who took part in a weight management programme delivered by the NHS through GP surgeries remain free of diabetes two years later. These latest findings of the Diabetes Remission Clinical Trial (DiRECT), funded by Diabetes UK and led by experts at Newcastle University and the University of Glasgow, were announced today at Diabetes UK’s…

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Hope for diabetics

Insulin-producing cells grown in lab

UC San Francisco researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes. Replacing these cells, which are lost in patients with T1 diabetes, has long been a dream of regenerative medicine, but until now scientists had not been able to figure out how to produce cells in a…

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Early detection

Prediabetes: don't wait, reduce your CVD risk

A diagnosis of prediabetes should be a warning for people to make lifestyle changes to prevent both full-blown diabetes and cardiovascular disease (CVD), according to scientists at Wake Forest School of Medicine. “We know that having diabetes increases the risk of developing cardiovascular disease, so in our study we wanted to determine what the absolute risk or probability of developing heart…

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Good boy, indeed

Diabetes: Dogs can help manage hypoglycaemic episodes

New research by the University of Bristol in collaboration with Medical Detection Dogs has found that the best trained alert dogs have the potential to vastly improve the quality of life of people living with Type 1 diabetes. As reported in PLOS One, on average trained dogs alerted their owners to 83 per cent of hypoglycaemic episodes in over 4,000 hypo- and hyper-glycaemic episodes that were…

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Neuropathy

How to protect your feet from diabetes

Diabetes is a disease that can cause a host of accompanying problems, for example nerve dysfunction that can lead to diabetic feet. John Giurini, DPM, Chief of Podiatric Surgery at Beth Israel Deaconess Medical Center, talks about where these complications come from and what can be done to deal with them.

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Unhealthy lifestyle

How working night shifts raises your risk of type 2 diabetes

Women who work intermittent night shifts and do not follow a healthy lifestyle face an especially high risk of type 2 diabetes, suggests a study published by The BMJ. The researchers found that the risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with…

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Glucose metabolism

Sugar and stress: how are they connected?

Chronic stress is a well-known risk factor for the development of psychiatric illnesses including depression disorders. The brain requires a great deal of glucose, and stress is known to alter glucose metabolism. However, if stress-associated mental impairments are linked to affected glucose metabolism remains to be seen. Researchers at the Department for Psychiatry and Psychotherapy at the Mainz…

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Cause and effect

Diabetes and heart failure: discovering the connection

Men with diabetes are 2.4 times more likely than non-diabetics to suffer heart failure and women are five times more likely. But why? A new Loyola University Chicago Stritch School of Medicine study reveals how, on a cellular level, diabetes can cause heart failure. The findings could lead to medications to treat and perhaps prevent heart failure in diabetes patients, researchers said. In a…

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Cardiology congress

ESC 2018: At the heart of research

When delegates from around 150 countries converge on Munich for ESC Congress 2018 they will no doubt reflect on what they themselves eat. Yes, nutrition is up for debate, questioning, for example, whether weight loss therapies can also prevent heart attacks and strokes. Results from the CAMELLIA-TIMI 61 trial of 12,000 overweight individuals with established cardiovascular disease or diabetes…

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Heat therapy

Soaking in a hot tub has unexpected benefits, researchers find

According to new research, obese women with polycystic ovary syndrome (PCOS) may be able to improve their health outlook with a particularly enjoyable form of therapy: regular sessions in a hot tub. The research found that soaking in a hot tub several times per week for two months results in improved measures of cardiovascular health, beneficial changes in fat tissue and other improvements…

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Epidemiological study

Vitamin D deficiency linked to increased diabetes risk

An epidemiological study conducted by researchers at University of California San Diego School of Medicine and Seoul National University suggests that persons deficient in vitamin D may be at much greater risk of developing diabetes. The scientists studied a cohort of 903 healthy adults (mean age: 74) with no indications of either pre-diabetes or diabetes during clinic visits from 1997 to 1999,…

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Smoking cessation

Common diabetes drug may also help with nicotine withdrawal

In a mouse study, a drug that has helped millions of people around the world manage their diabetes might also help people ready to kick their nicotine habits. In a report published in The Proceedings of the National Academy of Sciences of the United States of America (PNAS), investigators say metformin, an inexpensive drug commonly used to treat patients with type 2 diabetes, appears to block…

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Paradigm shift

Diabetes has 5 subtypes, not 2, study suggests

A completely new classification of diabetes which also predicts the risk of serious complications and provides treatment suggestions. We are now seeing the first results of ANDIS – a study covering all newly diagnosed diabetics in southern Sweden — published in The Lancet Diabetes & Endocrinology. The major difference from today’s classification is that type 2 diabetes actually consists…

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