Colon cancer

News • Global and regional burden of CRC

H. pylori may be behind more than one in five colorectal cancer cases worldwide

A study has found that exposure to Helicobacter pylori, a bacterium known to cause stomach ulcers and gastric cancer, may be associated with approximately 22% of colorectal cancer cases globally.

News • Organ-preserving treatment

New radiotherapy approach to spare rectal cancer patients surgery and stoma

Novel radiotherapy may save increasingly many rectal cancer patients from surgery and stoma. Finland is at the forefront of implementing this novel treatment.

News • Promising trial results

Rectal cancer treatment spares surgery for most patients

Surgical treatment of rectal cancer often means complete removal of the rectum. Now, new trial results suggest a different approach that lets patients keep their rectum – along with significant…

News • Reduction of mortality

New study shows effectiveness of bowel cancer screening

People who take part in screening for colorectal cancer may have as much as 43% lower risk of dying from the disease, according to new estimates from Sweden published in JAMA Network Open.

News • "Second pair of eyes" for endoscopists

Colorectal cancer: AI-assisted colonoscopy improves adenoma detection

A multicenter randomized clinical trial shows that real-time AI-assisted colonoscopy significantly improves adenoma detection among individuals at high risk for colorectal cancer.

News • Circulating tumor DNA status

Colorectal cancer: blood test shows who benefits from chemotherapy after surgery

A blood test for ctDNA may help identify which patients with colorectal cancer that has spread to the liver are most likely to benefit from chemotherapy after surgery, according to new research.

News • Treatment-resistant tumours

Researchers tear off "invisibility cloak" of colon cancer

A study from the University of Calgary shows that removing a single gene makes colon cancer cells a target for immunotherapy — a fundamental breakthrough.

News • dMMR prediction

AI helps analyse colorectal cancer samples

A new AI model enables more efficient analysis of tissue samples taken from colorectal cancer tumours. This can help shorten diagnosis times, reduce costs, and improve diagnostic accuracy.

News • Swiss national study reveals

Colorectal cancer on the rise among people under 50

The incidence of colorectal cancer is rising among younger individuals, sometimes as early as their thirties. The research also shows the challenge of late diagnoses and calls for increased awareness.

News • Prediction of treatment response

Colon and rectal cancer: new biomarker shows which patients benefit from immunotherapy

A multidisciplinary team of pathologists, oncologists and biologists has discovered a new biomarker to determine whether immunotherapy may work in people with colon and rectal cancer.

News • Inflammatory marker detection

New blood test targets rising bowel cancer rates

Earlier detection, better outcomes: A new blood test for bowel cancer screening is designed to transform cancer outcomes by moving away from invasive or unpleasant methods.

News • Exploring the mutational landscape

Colorectal cancer: DNA testing unlocks hereditary clues

DNA analysis of colorectal polyps provides important additional information on the development of these polyps and colorectal cancer, research finds. This leads to better diagnostics and treatment.

News • Dual-barrier tumours

How colorectal cancer evades immunotherapy (and what to do about it)

Most patients with metastatic colorectal cancer do not respond to immunotherapy—but why? A new study shows how the tumours block the immune system through two complementary mechanisms.

Article • Reshaping GI cancer care

Pathologists at the heart of precision oncology

Biomarker testing is ushering in a novel era of therapy personalisation for gastroesophageal and colorectal cancers, according to experts presenting at the 37th European Congress of Pathology in Vienna this September. During a session on state-of-the-art in gastrointestinal biomarkers, speakers outlined how targeted therapies and immunotherapies are transforming treatment options – but…

News • Research reveals infiltrating microbes

How bacteria in tumors drive treatment resistance in cancer

Researchers have discovered a previously unknown mechanism that explains how bacteria within a tumor can drive treatment resistance in patients with oral and colorectal cancer.

News • Optical technique

AI-assisted autofluorescence imaging to early detect colorectal cancer

An advanced imaging method that uses the natural glow of tissues could help detect subtle differences in the tissue’s biochemistry, offering a way to earlier detect colorectal cancer via endoscopy.

News • Implicit information

In-depth AI microbiome analysis reveals colorectal cancer

Scientists developed an AI-based approach to diagnose colorectal cancer from different microbial subgroups in the gut microbiota – a non-invasive and low-cost alternative to colonoscopy screening.

News • Adenoma detection rate

Using AI support makes endoscopists lose skills, study finds

AI tools for adenoma polyp detection are designed to help increase the accuracy of colonoscopies. However, a new study finds that using AI may lead to loss of detection skills in health professionals.

News • Microsatellite instability

Predicting tumor MSI status for precision cancer treatments

Microsatellite instability-high (MSI-H) tumors are associated with better clinical outcomes. A novel AI model for accurate MSI prediction could help battle gastric and colorectal cancers.

News • Study shows benefits of earlier FIT

Colorectal cancer screening: 40 is the new 50

Starting fecal immunochemical testing (FIT) early significantly reduces both the incidence and mortality of colorectal cancer. These results of a new study support earlier screening.

News • Colorectal Cancer Screening

CT colonography proves more cost-effective than stool DNA tests

New research demonstrates CT colonography outperforms stool DNA testing in both clinical effectiveness and cost savings for colorectal cancer screening.

News • New organ-preserving options explored

Five major advances in anal and rectal cancer treatment with radiotherapy

From organ-preserving treatments to chemo-immunotherapy combinations: five studies presented at ESTRO 2025 showcase how radiotherapy is reshaping the treatment landscape for anal and rectal cancer.

News • Exploring the role of colibactin

Research links bacterial toxin to colorectal cancer

The incidence of colorectal cancer in young adults has doubled over the last 20 years, with no known reason. Now, a new study links this mysterious trend to childhood exposure to a bacterial toxin.

News • Review of colonoscopy CADe systems

AI for colon cancer detection: "Right now, this is version 1.0. We need version 4.0”

A rigorous review of evidence showed that AI-assisted technology helps identify colorectal polyps. However, its impact on preventing colon cancer remains unclear.

News • Behavioural intervention study

Want to boost bowel cancer screening response? Add a deadline

Screening for colorectal cancer has proven effective for reducing mortality, but response rates are lacking. A new study finds that putting on the pressure can provide the necessary encouragement.

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