Research

When scientific curiosity paves the way for improved healthcare: Read more about promising studies and trials that lead to more effective drugs, procedures as well as medical guidelines.

News • Impact on type 2 diabetes

Gut microbiota shape metabolic health after bariatric surgery

Changes in gut microbiota after bariatric surgery are strongly linked to altered metabolic health and sustained improvement in type 2 diabetes, according to a new study.

News • Larger sample yield

Ultrasonic needle could reshape cancer diagnostics

A new ultrasonic needle for tumour diagnostics could be used to diagnose salivary gland tumours with far greater precision, a new study finds. The device also shows potential for other cancers.

News • Polycystic ovary syndrome

Study links PCOS and heart disease

Heart disease risk has been found to increase in women with polycystic ovary syndrome (PCOS), even in those with normal weight, according to new research.

Article • San Antonio Breast Cancer Symposium (SABCS)

Young women and breast cancer: research in focus

At the San Antonio Breast Cancer Symposium (SABCS), three experts presented new approaches and study results for the treatment of breast cancer in young women.

News • Effects on autoimmune disease

Will pregnancy make myasthenia gravis worse? Study sheds new light

Many women with myasthenia gravis choose not to have children due to fear that the disease will get worse during or after pregnancy. Now, a new study investigated the connection to the autoimmune…

News • Targeted immunotherapy

Implantable cytokine factories to help treat ovarian cancer

Researchers have reported results from a first-in-human trial evaluating a novel cell-based platform for localized delivery of interleukin-2 (IL-2) in patients with advanced ovarian cancer.

News • Neurology

When the ageing brain loses its molecular balance

Researchers at the Leibniz Institute on Aging have shown that oxidative stress impairs protein quality control in the brain – and that this process is reversible.

News • Oncology

Nanozymes take on brain tumours from the inside

Researchers are developing nanozymes to improve treatment of aggressive brain tumours. The tiny particles can be activated by near-infrared light and applied directly during surgery.

News • Immuno-Oncology

Killer cells caught in the act: a 3D view of T lymphocytes

Researchers have used cryo-expansion microscopy to capture cytotoxic T lymphocytes destroying cancer cells in unprecedented 3D detail, opening new paths in immuno-oncology.

News • Microscopy

New microscopy method maps lipids without labels

A new microscopy method reads lipids' natural spectral fingerprints using mid-infrared light and ultrasound – no fluorescent labels needed, less stress for living cells.

News • Study shows challenges in primary care

Why diagnosing endometriosis often takes years

Endometriosis affects up to one in ten women and girls of reproductive age, but for many, the path to diagnosis is both long and complex. Now, two new studies explain the diagnostic challenges in primary care.

News • Insights into asymptomatic disease cases

Some brains stay sharp in spite of Alzheimer’s – here's why

Why do some older adults remain mentally sharp despite having Alzheimer's? Decoding this natural resilience could pave the way for earlier detection and new strategies to prevent memory loss.

News • Ventricle morphology

Hydrocephalus: 3D brain marker helps predict shunt surgery success

A 3D brain marker may help identify which patients with idiopathic normal pressure hydrocephalus (iNPH) benefit from shunt surgery – improving outcomes and sparing others from ineffective treatment.

News • Mammary tumorigenesis

New marker identifies which breast lesions will progress to cancer

Not all precancerous lesions will develop into tumours, yet the majority are treated as if they were already breast cancer. A new marker could help identify the relevant cases and avoid overtreatment.

News • Lowering tissue reactivity

Towards more biocompatible brain implants

Neural implants show great potential, but the brain's reaction to foreign objects remains a challenge. New research insights could now pave the way for more biocompatible brain implants.

News • Methylation-sensitive editing by Cas9

Targeting tumour DNA with CRISPR variant

Researchers have taken an early but promising step toward a cancer therapy that targets and destroys tumor cells with high precision, using a variant of the DNA editing tool CRISPR.

News • Immunology

How obesity impairs vaccine response

Being overweight can reduce vaccine effectiveness, new research finds. The findings explore differences in immune response, and may lead to more effective vaccines for patients with obesity.

News • Behavioural, lifestyle and psychosocial information

“Digital twin” AI links mental health to type 2 diabetes

A new study using a “digital twin” AI model has found that factors such as loneliness, insomnia and poor mental health substantially raise a person’s future risk of developing type 2 diabetes.

News • Potential osteoarthritis treatment

Researchers investigate menstrual blood for cartilage repair

New research reveals that extracellular vesicles derived from menstrual blood stromal cells can improve cartilage repair, suggesting an innovative cell-free therapy for osteoarthritis.

News • Study explores reason for health benefits

How sauna bathing boosts the body's immune responses

Regular sauna bathing has been associated with several beneficial health effects. A new study from Finland may help explain how these effects develop in the body.

News • Genetic CAD risk scores

Researchers link diabetes subgroups to coronary heart disease risk

Researchers have now investigated whether a person’s genetic predisposition to different diabetes subgroups can help assess the risk of developing coronary artery disease.

News • Biomechanical mapping of tumor growth

New biomarker helps assess glioblastoma aggressiveness

Researchers have developed a new MRI-based method that enables objective quantification of the growth of the most aggressive brain tumours, particularly glioblastoma.

News • Environmental medicine

New study links pesticide exposure to cancer risk

A new scientific study reveals a strong link between exposure to agricultural pesticides in the environment and the risk of developing cancer on a national scale.

News • Dynamic in vitro platform

“Breathing” organoid offers new insights into lung disease

A new type of “breathing” lung organoid enables quantitative measurement of how easily the lung expands - and may provide a new way to study diseases such as pulmonary fibrosis.

News • Single-cell spatial atlas

Breast cancer: map explores role of aging tissue

As women age, their breast tissue goes through major changes, with the most dramatic changes at menopause, but also during pregnancy and childbirth. A map reveals the impact on breast cancer.

News • Review on treatment outcomes

Exploring the impact of chronic stress on cancer

A new review shows that chronic stress may actively drive cancer progression. Therefore, psycho-oncology should be part of standard cancer care, the researchers argue.

News • Treatment de-escalation

Patient-tailored radiotherapy effectively prevents breast cancer recurrence

The chances of breast cancer recurring remain very low when patients are treated with radiotherapy that is tailored to their individual risk following chemotherapy and surgery, new study results find.

News • Disease-related distress

Cancer-related anxiety: tool reveals emotional impact

Fear that their cancer will progress or worsen is one of the most common concerns among people living with this disease. A new tool aims to reliably measure patients’ anxiety about their cancer.

News • Nanozyme-empowered responsive hydrogel

Smart bandage could heal and monitor wounds at the same time

Australian researchers have unlocked the possibility of creating smart wound dressings that enable real-time monitoring while also delivering healing agents in one simple, scalable platform.

News • Impact on longevity and cancer

“The thymus has been overlooked for decades”

Two new studies explore the role of the thymus – a small organ in the chest, and possibly a missing piece in explaining why people age differently, and why cancer treatments fail in some patients.

News • PARP inhibitors distribution

“Hidden drug storehouses” could explain treatment resistance in cancer

Why do some cancer cells develop treatment resistance? The answer may lie in hidden “storage hubs” inside tumour cells, which create uneven drug exposure across tumours, according to new research.

News • Research onthe glymphatic system

Broken waste-clearance in the brain may lead to psychosis

Early dysfunction of the glymphatic system — the network responsible for removing waste from the brain — could be a key vulnerability factor for the onset of psychosis, according to new research.

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