Biomarkers

News • Epigenetic biomarkers

Revealing risk of cardiovascular disease in type 2 diabetes

Type 2 diabetes greatly increases the risk of heart attacks, strokes, anginas, and other coronary heart diseases. Therefore, biomarkers to predict individual risk are needed, experts say.

Article • Blood-based biomarkers under scrutiny

BBB testing for universal Alzheimer’s screening? It’s complicated

Do laboratory tests using blood-based biomarkers (BBB) represent the next type of universally recommended screening tests for Alzheimer's disease (AD)? Experts curb the high expectations for…

News • Obsessive-compulsive disorder

Neural biomarkers for OCD discovered

Using electrodes implanted in the brain, researchers observed specific brain waves that could serve as a biomarker for obsessive-compulsive disorder (OCD) and are an important step towards more…

News • Neurodegenerative disease

Alzheimer's: middle-age brain biomarkers give an earlier shot at prevention

The earlier Alzheimer's disease is detected, the more effective treatments become. Now, a Finnish study shows that signs related to Alzheimer’s may already be found in the brain in middle age.

News • Potential diagnostic medium

Saliva analysis could reveal risk of cancer, heart disease or Parkinson’s

Molecular markers in saliva could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases, new research finds.

News • Dual role of tau phosphorylation

Surprising find: Alzheimer's biomarker found in newborn brains

What do the brains of newborns and patients with Alzheimer's disease have in common? Researchers have discovered a surprising shared trait - which might provide new insights into the disease.

News • Genetic signature mapping

Diagnosing Parkinson’s from a blood sample

In a world first, researchers have identified a set of biomarkers that could someday make it easy to spot Parkinson's disease in a patient’s blood sample.

News • Retinal functional impairments as biomarkers

Eye exam shows potential for early detection of Parkinson's disease

Researchers from Université Laval discovered that the retina of people with Parkinson's disease responds differently to light than that of healthy people. This offers new diagnostic options.

News • Promising biomarker found

Broad rim lesions predict multiple sclerosis progression

A new biomarker for multiple sclerosis: the inflammatory cell rim from microglial cells surrounding brain lesions was found to directly correlate with the severity and speed of disease progression.

News • Reactions to noise as biomarkers

Tinnitus diagnosis via AI-powered face scan

Pupil dilation and involuntary facial movements could provide a window into diagnosing tinnitus. A new method uses AI to detect minuscule reactions to various sounds and noises.

News • Combining spatial transcriptomics, pseudotime and machine learning

More precise than PSA: New biomarkers for prostate cancer found in urine

Using AI and extensive analyses of gene activity in tumours, researchers have found new, precise biomarkers to diagnose prostate cancer at an early stage through a simple urine sample.

News • Blood-based marker P-tau217

Simple, yet effective way to early detect Alzheimer's disease

A new, simpler and cheaper analytical method for the early detection of Alzheimer's disease could help bring blood tests into the healthcare system globally, according to a new study.

News • Cardiac event marker

Coronary artery calcium score: useful regardless of age

A large new study of more than 40,000 patients finds that a zero coronary artery calcium score continues to be an accurate indicator of a low risk for a coronary heart event even as a person ages.

News • Triple-negative breast cancer

Novel radiotracer identifies TNBC biomarker

A new PET tracer has the potential to play a critical role in the diagnosis, treatment, and monitoring of aggressive triple-negative breast cancer (TNBC), improving clinical outcomes for patients.

Article • Detection of neurodegenerative condition

Developing blood biomarkers to diagnose Alzheimer’s disease

There is no known cure for Alzheimer’s disease (AD), although prescription drug-based treatments that can slow AD progression in some patients are starting to enter clinical use. Biomarkers, quantifiable characteristics of biological processes or pathological conditions of the body, are making it possible to help identify and measure the presence and extent of AD and its degenerative…

Article • Promising, but in need of further validation

Implementation challenges of blood biomarkers for Alzheimer’s disease

Blood-based biomarker (BBB) tests may represent the best weapon to combat the soaring rates of Alzheimer’s disease (AD) throughout the world. Existing clinically validated tests are currently deployed to facilitate diagnosis, to monitor disease and effectiveness of treatments, to quantify progression, and to determine if a patient is appropriate for treatment or participation in a clinical…

News • Reseach on neurofilament light chain proteins

ALS: Improving diagnosis and management with new blood test

A new blood test, using neurofilament light chainproteins as biomarker, could lead to better diagnosis and management of amyotrophic lateral sclerosis (ALS).

News • Cell-free tumor DNA analysis

Liquid biopsy to unlock breast cancer treatments

New research highlights the potential of circulating tumor DNA (ctDNA) analysis as a non-invasive method to identify actionable biomarkers for breast cancer, enabling individualized therapies.

News • Multi-omics-based prediction

Pancreatic cancer: 'biomarker panel' brings hope for early detection

The discovery of a 'biomarker panel' could have a profound impact on the ability to identify patients at risk of developing pancreatic cancer at an earlier stage, researchers hope.

News • Hyper-elevated RNAPII detection

New biomarker predicts aggressiveness of brain, breast cancer

Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting the aggressiveness of meningioma brain tumors and breast cancers.

News • Research on RAD51 biomarker

Next-generation sequencing for personalizing prostate cancer treatment

Certain gene alterations can serve as a prognostic and predictive biomarker for prostate cancer. Now, researchers confirm the feasibility of using NGS on this marker for precise patient stratification and treatment selection.

News • Quantification of serum biomarkers

Early detection of lung cancer with low-cost biosensor

A sensor, similar to glucose monitoring devices, detects lung cancer biomarkers from a blood sample in just 40 minutes. The technology has potential to identify at-risk patients and tailor treatments.

Article • Molecular meets digital

Single-cell multiplex imaging: a powerful tool for digital pathology

Multiplex imaging can play a critical role in unravelling the tumour microenvironment. The potential and benefits of the emerging approach – a way to extract information from human tissue samples by visualising many more biomarkers than traditional microscopy – was highlighted in presentations during the 36th European Congress of Pathology in Florence, Italy. Speakers also discussed novel…

News • Groundwork for new treatments

Fibrosis a prognostic biomarker for HER2-negative breast cancer

A new study confirms fibrosis as a prognostic indicator in HER2-negative, the most common breast cancer, and opens the way to antifibrotic drug treatments.

News • Neurodegenerative diseases

Tauopathy or Alzheimer's? Biomarker and PET imaging for improved diagnosis

Researchers have identified biomarkers that, in conjunction with PET imaging, enable doctors to reliably distinguish between primary 4-repeat tauopathies and Alzheimer's disease.

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