#biomarkers

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Predictive proteins

Biomarkers in COVID-19 patients could predict how ill they become

Researchers at the Francis Crick Institute and Charité – Universitätsmedizin Berlin have identified 27 protein biomarkers that could be used to predict whether a patient with COVID-19 is likely to become severely ill with the disease. People infected with SARS-CoV-2, the virus which causes COVID-19, respond differently. Some do not develop any symptoms, some need to be hospitalised and, for…

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HNSCC diagnostics

Head and neck cancer: Novel prognostic biomarker could double survival

A recent study conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) discovered a novel genetic biomarker which can predict the survival of head and neck cancer patients. There are over 0.7 million new head and neck squamous cell carcinoma (HNSCC) cases globally each year. However, currently there is no clinical implementation of any genetic biomarker to…

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First biomarker for regenerative medicine

MRI predicts efficacy of stem cell therapy for brain injury

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve…

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Potentials and pitfalls for IB development

Imaging biomarkers: Close surveillance is mandatory

Imaging biomarkers (IB) have advanced tremendously since first described 25 years ago, but many challenges still block their widespread use. During the EuSoMII’s annual meeting in Valencia, Dr Ángel Alberich-Bayarri gave pragmatic solutions to tackle current bottlenecks and explained why close surveillance is mandatory for further development of IB. However, these need close surveillance with…

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Assessment of brain tumour treatment response

Developing AI algorithms for earlier glioblastoma detection

Novel advanced imaging biomarkers are being developed in a series of studies at several UK centres that may lead to the earlier assessment of treatment response to glioblastoma (GBM) and a better survival rate. Through a number of clinical trials – and the application of artificial intelligence (AI) to retrospective data sets – the aim is to highlight approaches that will enable clinicians to…

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Dementia diagnostics

Lack of sleep might throw off Alzheimer’s test

A preliminary study has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau, a biomarker for Alzheimer’s disease, in their blood than when they had a full, uninterrupted night of rest. The study is published in the January 8, 2020, online issue of Neurology, the medical journal of the American Academy of Neurology. Tau is a protein found in…

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Biomarker for personalised treatment

Non-invasive technique to assess brain tumours in children

Ground-breaking research by the University of Birmingham has discovered a new technique to assess the aggressiveness of childhood brain tumours. Funded by Children with Cancer UK, Action Medical Research and The Brain Tumour Charity, the study is the first of its kind and will allow clinicians to give more personalised treatments for childhood brain cancers, which currently account for one third…

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Smart patch

ELSAH: A wearable to determine biomarkers

The EU four-year project ELSAH, which began at the dawn of 2019, aims to design a wearable to enable continuous determination of biomarker concentrations. Project coordinator Dr Joerg Schotter, Molecular Diagnostics, Centre for Health & Bioresources, AIT Austrian Institute of Technology GmbH, explains the project’s objectives and potential applications for the planned wearable.

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"Umbrella" trial

Urine test detects acute kidney transplant rejection

Early non-invasive detection of kidney rejection after transplantation was the central aim of a collaboration between Prof. Dr. Bernhard Banas, Chairman of Nephrology at the University Hospital Regensburg (UKR) and the medical diagnostics company, numares. The results of their joint clinical trial “UMBRELLA” were just published in EBioMedicine and presented at the American Society of…

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Presented at the NCRI cancer conference

Simple blood test for early detection of breast cancer

Breast cancer could be detected up to five years before there are any clinical signs of it, using a blood test that identifies the body’s immune response to substances produced by tumour cells, according to new research presented at the 2019 NCRI Cancer Conference. Cancer cells produce proteins called antigens that trigger the body to make antibodies against them – autoantibodies. Researchers…

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Respiratory failure and sepsis

Cheap, quick test identifies major risks for pneumonia patients

Spanish researchers in Valencia have identified specific fragments of genetic material that play a role in the development of respiratory failure and sepsis in pneumonia patients. Presenting the research at the European Respiratory Society International Congress, Dr Francisco Sanz said the findings could enable doctors to test quickly for these biological markers when a patient is admitted to…

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Fat radiomic profile

Using AI to predict heart attacks

Technology developed using artificial intelligence (AI) could identify people at high risk of a fatal heart attack at least five years before it strikes, according to new research funded by the British Heart Foundation (BHF). The findings are being presented at the European Society of Cardiology (ESC) Congress in Paris and published in the European Heart Journal. Researchers at the University of…

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Methylation of microRNA

Is it cancer? New method could tell the difference

Levels of molecules associated with genetic function, such as microRNA, can be an important indicator of abnormal activity associated with cancer. However, little is known about how different molecules are altered in cancerous cells. Now, researchers from Japan have found a new way of distinguishing cancerous from non-cancerous tissues. In a study published in Nature Communications, researchers…

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Mortality risk

A new biomarker to predict your lifespan?

Fourteen metabolic biomarkers can predict long term mortality in individuals helping to determine life expectancy in general populations, a new study in the journal Nature Communications reports. In the largest study of its kind, researchers from Leiden University Medical Center in the Netherlands and the University of Surrey investigated predictors of long-term mortality risk. Current predictors…

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Biomedical engineering

Cornea restoration: Scientists develop physical biomarker

Our eyes – considered by many to be the windows to the soul – need constant care, and as we age, they sometimes also need significant repair. The panes of these windows – the corneas – are transparent tissues that have been the focus of some of the oldest and most common transplantation surgeries. Now thanks to researchers in Kyoto, some such transplants may become even safer. The team,…

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Artificial Intelligence

Allying AI to biomarkers is powerful but validation remains challenging

Using artificial intelligence (AI) to push development of imaging biomarkers shows great promise to improve disease understanding. This alliance could be a game changer in healthcare but, to advance research, clinical validation and variability of results must be factored in, a prominent Spanish radiologist advises. In clinical practice efforts are already ongoing to apply AI to obtain new…

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Flow cytometry

Living cells – the essential biomarker

The team of the Heinz Nixdorf Chair of Biomedical Electronics at the Technical University of Munich focuses on innovative diagnostic tools to accelerate the development towards personalized medicine. Therapies tailored to the individual patient – this is the future not only of oncology but of many medical disciplines. “At this point, however,” concedes Professor Dr Oliver Hayden,…

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Improvement of cardiac care

Rapid myocardial infarction verification

The use of troponin assays to rule in or rule out myocardial infarction (MI) rapidly is critical on several levels. The quick result can reassure the patient that they have not had a heart attack and can return home safely; or, in the event of MI, the relevant treatment can start very soon. It also ensures that clinicians can make the right decision with confidence. Troponin levels have been the…

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Making the invisible visible

New method opens unexplored realms for liquid biopsies

Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients’ blood and urine. These “liquid biopsies” are less invasive than a traditional biopsy, and can provide information about what’s happening throughout the body instead of just at a single site. Now researchers at the University of Michigan Rogel Cancer…

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Post-cancer impairment

'Chemobrain': New biomarkers found

Cognitive impairment associated with cancer, also known as “chemobrain”, has gained recognition as a complication of the disease and its treatment, as it can negatively affect the daily lives of cancer patients and survivors. Chemobrain can be subtle yet persistent, with some cancer patients reporting difficulties related to memory and attention even months after completing their treatment.…

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New hematologic biomarker

FDA clearance for early sepsis indicator

A major milestone on its strategic mission to lead in sepsis diagnostics, Beckman Coulter announced that its Early Sepsis Indicator has received 510(k) clearance from the U.S. Food and Drug Administration (FDA). Sepsis is a global healthcare crisis that affects more than 30 million people worldwide. The Early Sepsis Indicator is a first-of-its-kind, hematology-based cellular biomarker that is…

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