Biomarkers

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microRNAs hint at cognitive decline

Researchers find warning signs for dementia in the blood

esearchers at the DZNE and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. Their findings, which are presented in the…

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Amyotrophic lateral sclerosis

New predictive biomarkers for ALS identified

Some blood lipid biomarkers linked to cardiovascular disease risk are also associated with a lower risk of amyotrophic lateral sclerosis (ALS) suggest the findings of a large epidemiology study. ALS…

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Cardiovascular disease prevention

Why a good night's sleep can save your heart

In a new study, researchers at Lund University and Uppsala University have seen a clear connection between how long a person sleeps and a number of biomarkers linked to cardiometabolic diseases such…

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Early diagnosis proteins

Study identifies 15 new biomarkers for pre­-dementia

A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent…

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Medication development platform

Smart biomarkers to find new drugs against brain diseases

Dr. Hayder Amin and Dr. Caghan Kizil from the DZNE’s Dresden site aim to speed up developing drugs against brain diseases through cutting-edge technology. To this end, they are generating an…

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Coronavirus disease biomarkers

New Covid-19 testing method gives results within one second

The Covid-19 pandemic made it clear technological innovations were urgently needed to detect, treat, and prevent the SARS-CoV-2 virus. A year and a half into this epidemic, waves of successive…

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Prognosis

Better heart failure outcomes through biomarker-based treatment

In a recent study by University of Alabama at Birmingham researchers, findings indicate that among patients with heart failure, obesity is associated with a higher risk of heart failure hospitalization or death due to cardiac causes. However, achieving biomarker-based treatment goals in heart failure improves the prognosis for patients irrespective of their obesity status.

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Intrahepatic cholangiocarcinoma

A new approach for treating bile duct cancer

Intrahepatic cholangiocarcinoma (ICC) develops within the liver. With one to two cases per 100,000 inhabitants in Germany, ICC is one of the rare diseases overall, but it is the second most common liver cancer. The aggressive bile duct tumour remains clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited…

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Mass spectrometry

"Protein fingerprint" rapidly identifies Covid-19 biomarkers

Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes. It is faster and cheaper than a conventional blood count. To demonstrate the technique’s potential, the researchers used blood plasma collected from Covid-19 patients.…

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Wearable for blood pressure, heart rate, glucose and more

New patch monitors multiple markers at once

Engineers at the University of California San Diego have developed a soft, stretchy skin patch that can be worn on the neck to continuously track blood pressure and heart rate while measuring the wearer’s levels of glucose as well as lactate, alcohol or caffeine. It is the first wearable device that monitors cardiovascular signals and multiple biochemical levels in the human body at the same…

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Advancing diagnostic accuracy

PSMA PET/CT in prostate cancer evaluation

Hybrid PET/CT imaging can fully play to its strengths and steer treatment towards more effective procedures for diagnosing prostate cancer. The examination of the specific antigen PSMA with hybrid PET imaging enables treatment monitoring with significantly higher diagnostic accuracy than conventional imaging and therefore, Professor Clemens Cyran believes, will soon become the standard diagnostic…

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Microneedles

No more needles for bloodtests?

Blood draws are no fun. They hurt. Veins can burst, or even roll — like they’re trying to avoid the needle, too. Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and…

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An unexpected and novel target

How our biological clock could save us from prostate cancer

Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It’s no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the…

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Predictive proteins

Biomarkers in COVID-19 patients could predict how ill they become

Researchers at the Francis Crick Institute and Charité – Universitätsmedizin Berlin have identified 27 protein biomarkers that could be used to predict whether a patient with COVID-19 is likely to become severely ill with the disease. People infected with SARS-CoV-2, the virus which causes COVID-19, respond differently. Some do not develop any symptoms, some need to be hospitalised and, for…

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HNSCC diagnostics

Head and neck cancer: Novel prognostic biomarker could double survival

A recent study conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) discovered a novel genetic biomarker which can predict the survival of head and neck cancer patients. There are over 0.7 million new head and neck squamous cell carcinoma (HNSCC) cases globally each year. However, currently there is no clinical implementation of any genetic biomarker to…

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First biomarker for regenerative medicine

MRI predicts efficacy of stem cell therapy for brain injury

Scientists at Sanford Burnham Prebys Medical Discovery Institute and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury—a first-ever “biomarker” for regenerative medicine that could help personalize stem cell treatments for neurological disorders and improve…

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Potentials and pitfalls for IB development

Imaging biomarkers: Close surveillance is mandatory

Imaging biomarkers (IB) have advanced tremendously since first described 25 years ago, but many challenges still block their widespread use. During the EuSoMII’s annual meeting in Valencia, Dr Ángel Alberich-Bayarri gave pragmatic solutions to tackle current bottlenecks and explained why close surveillance is mandatory for further development of IB. However, these need close surveillance with…

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Dementia diagnostics

Lack of sleep might throw off Alzheimer’s test

A preliminary study has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau, a biomarker for Alzheimer’s disease, in their blood than when they had a full, uninterrupted night of rest. The study is published in the January 8, 2020, online issue of Neurology, the medical journal of the American Academy of Neurology. Tau is a protein found in…

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Biomarker for personalised treatment

Non-invasive technique to assess brain tumours in children

Ground-breaking research by the University of Birmingham has discovered a new technique to assess the aggressiveness of childhood brain tumours. Funded by Children with Cancer UK, Action Medical Research and The Brain Tumour Charity, the study is the first of its kind and will allow clinicians to give more personalised treatments for childhood brain cancers, which currently account for one third…

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Smart patch

ELSAH: A wearable to determine biomarkers

The EU four-year project ELSAH, which began at the dawn of 2019, aims to design a wearable to enable continuous determination of biomarker concentrations. Project coordinator Dr Joerg Schotter, Molecular Diagnostics, Centre for Health & Bioresources, AIT Austrian Institute of Technology GmbH, explains the project’s objectives and potential applications for the planned wearable.

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"Umbrella" trial

Urine test detects acute kidney transplant rejection

Early non-invasive detection of kidney rejection after transplantation was the central aim of a collaboration between Prof. Dr. Bernhard Banas, Chairman of Nephrology at the University Hospital Regensburg (UKR) and the medical diagnostics company, numares. The results of their joint clinical trial “UMBRELLA” were just published in EBioMedicine and presented at the American Society of…

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Presented at the NCRI cancer conference

Simple blood test for early detection of breast cancer

Breast cancer could be detected up to five years before there are any clinical signs of it, using a blood test that identifies the body’s immune response to substances produced by tumour cells, according to new research presented at the 2019 NCRI Cancer Conference. Cancer cells produce proteins called antigens that trigger the body to make antibodies against them – autoantibodies. Researchers…

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