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Pancreas

The pancreas produces important hormones – especially insulin, which regulates blood sugar, and ghrelin, which stimulates appetite. If the function of the pancreas is disturbed, diabetes can be the result, but gastrointestinal diseases such as pancreatitis are also highly relevant in medicine – as is pancreatic cancer, which is one of the most aggressive and deadly tumour types.

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News • PDAC subtype classification

Attacking the roots of pancreatic cancer

Pancreatic cancer is not just one disease, but that’s the way it is currently treated. New work from Columbia University could help pave the way for a change.

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News • Immunotherapy effectiveness

Sex differences in pancreatic cancer: researchers reveal possible explanation

For pancreatic cancer, the effect of immunotherapy is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference.

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News • Inhibition of solid tumor growth

'Paralyzing' pancreatic cancer with low-intensity ultrasound

A new study from Spain has demonstrated the efficiency of an ultrasound radiation-based therapy on the inhibition of cancer cell motion in pancreas cancer models.

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News • Trial finds improved survival rates

Pancreatic cancer: chemotherapy before surgery brings benefits

Treating pancreatic cancer patients with chemotherapy before surgery significantly improved 1-year survival rates compared to immediate surgery, a randomised clinical trial has found.

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Article • Visceral imaging

Endosonography: AI takes on the “supreme discipline”

Endosonography poses unique challenges for medical professionals, because two demanding disciplines have to be mastered at the same time. The use of artificial intelligence (AI) could help speed up…

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News • Immune systems timulation

Using senescent cells as anti-cancer vaccines

Researchers from Barcelona report that vaccination with senescent cells shows promise in experimental models of melanoma and pancreatic cancer.

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News • Ductal adenocarcinoma

Pancreatic cancer ‘priming’ may make chemotherapy more effective

A new approach to ‘prime’ the tumour environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer. In preclinical models, a team at the Garvan Institute of Medical Research could enhance the tumours’ response to chemotherapy by reducing the stiffness and density of the connective tissue known as the stroma,…

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News • Combined chemotherapy

Pancreatic cancer: New treatment promising for older patients

Pancreatic cancer is a disease of the elderly: the average age of patients is 72. In Austria, about 1,600 people are diagnosed each year. Since pancreatic cancer has no specific symptoms, it is not usually diagnosed until the tumor is locally advanced or has already metastasized. Once the tumor has metastasized, it is usually no longer treatable by surgery or radiotherapy. In addition, the drug…

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News • Genetic alterations

Same mutation, different cancers: researchers explore connections

Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in…

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Article • Oncology

Pancreatic cancer - current challenges and future direction

Pancreatic cancer is one of the deadliest cancers in the world, and one of the most difficult to treat. In 2020, an estimated 495,000 individuals worldwide were diagnosed with pancreatic cancer and an estimated 466,000 died, according to statistics from the World Health Organization’s International Agency for Research on Cancer. Most patients with advanced disease die within a year of…

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News • RAS protein mutation

New treatment approach targets cancer 'Death Star'

A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at Leeds. The mutated form of the RAS protein has been referred to as the “Death Star” because of its ability to resist treatments and is found in 96% of pancreatic cancers and 54% of colorectal cancers. RAS is a protein important for health but in its mutated form it can…

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News • Pancreatic ductal adenocarcinoma (PDAC)

Cutting-edge approach to fighting deadly form of pancreatic cancer

By 2030, the most lethal form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is projected to become the second leading cause of cancer-related deaths in the United States. Not only are therapeutic options limited, but nearly half of PDAC patients who have their tumors removed surgically experience disease recurrence within a year, even with chemotherapy. For more advanced stages,…

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Video • Bioprinting breakthrough

3D printed mini pancreas to help fight diabetes

First you see it as a transparent shape on a computer screen – a small electronic replica of the human pancreas. Then just 30 seconds later the tissue is printed out on a bioprinter, blood vessels and all, from a sample of human stem cells. This amazing feat is possible thanks to new technology created at EPFL’s Laboratory of Applied Photonics Devices (LAPD) and further developed by…

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News • Stopping the spread

Research sheds new light on pancreatic cancer metastasis

With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs. A team of researchers at the College of Medicine at the University of Oklahoma has published a new study in the journal…

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News • Expert prediction

How will Covid affect cancer death rates in 2021?

Researchers have called on European policymakers to make adequate resources available to tackle pancreatic cancer, a disease that is almost invariably fatal and where little progress has been made over the past 40 years. In the latest predictions for cancer deaths in the EU and UK for 2021, published in the cancer journal Annals of Oncology, researchers led by Carlo La Vecchia (MD), a professor…

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News • Insulin inhibitory receptor

New promising target for diabetes treatment

Researchers from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes…

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Article • Finding therapeutic targets

Pancreatic cancer: Seeking viable treatment strategies

Pancreatic cancer has the worst survival rate of any cancers, with immunotherapies currently offering negligible treatment benefits for patients. To help identify new therapeutic approaches, researchers from the University of Oxford have been focusing on leukocyte infiltration as a prognostic marker of the disease. Their study and findings were outlined by Dr Shivan Sivakumar during a session…

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News • Unique awareness campaign

Crafting quilts to fight pancreatic cancer

Chemistry researchers at the University of Strathclyde are aiming to raise awareness of pancreatic cancer – with the use of specially-made quilts. Fellow cancer researchers across the UK are being asked to send diagrams illustrating their work. These will then be used as the patterns for quilts made by skilled crafters. After the project is concluded, the Strathclyde researchers hope to be able…

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