Keyword: pancreas

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CancerSEEK

Single blood test screens for 8 cancer types

Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer. The test, called CancerSEEK, is a unique noninvasive, multianalyte test that simultaneously evaluates levels of eight cancer proteins and the presence of cancer gene mutations from circulating DNA in the blood. The test is aimed at…

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Enzyme discovery

Epigenetic agitator of pancreatic cancer cells identified

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect…

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Biomarker validation

Plodding toward a pancreatic cancer screening test

Pancreatic cancer is one of the most deadly types of malignancies, with a 5-year survival rate after late diagnosis of only about 5%. The majority of patients—about 80%—receive their diagnosis too late for surgery. The disease spreads quickly and resists chemotherapy. In short, there is an urgent need for diagnostic tools to identify this cancer in its earliest stages.

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Oncology

Pancreatic cancer: Enzyme renders tumors resistant

Scientists at the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM in Heidelberg have discovered the reason why some pancreatic tumors are so resistant to treatment. They have found that these tumor cells produce larger quantities of an enzyme that usually occurs in the liver and degrades many drugs. If this enzyme is blocked, the cancer cells become sensitive towards…