pathology

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Pathology informatics event

Panel Discussion on the use of digital pathology for remote diagnosis

Hamamatsu Photonics invites you to join us for a panel discussion with pathologist Matthew Hanna, MD and IT Manager Nikolas Stathonikos on Thursday, 9 July at 17:00 CET. In this rapidly evolving healthcare landscape triggered by COVID-19, pathology, and remote diagnosis have been elevated to critical topics. These two experts, representing both the clinical and information technology areas, will…

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UK experts raise concerns

COVID-19 antibody tests: Not a game-changer after all?

A group of senior clinical academics and physicians are concerned about the rapid roll out of COVID-19 antibody testing in England and are publicly questioning how good the tests are - or even what they mean. In a letter to The BMJ, they argue that there is currently no valid clinical reason for large scale testing, test performance has not yet been adequately assessed, and testing risks…

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Cancer research

Lymph node analysis to hunt down metastases

What makes tumor cells turn murderous? The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is investigating the mechanisms of metastasis formation – and searching for approaches for new treatments in the fight against cancer. Among other things, the research team at Fraunhofer ITEM has developed a method that enables them to analyze entire lymph nodes.

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From physical to computational staining

Deep learning accurately stains digital biopsy H&E slides

Tissue biopsy slides stained using hematoxylin and eosin (H&E) dyes are a cornerstone of histopathology, especially for pathologists needing to diagnose and determine the stage of cancers. A research team led by MIT scientists at the Media Lab, in collaboration with clinicians at Stanford University School of Medicine and Harvard Medical School, now shows that digital scans of these biopsy…

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Lab medicine in the Netherlands

Digital pathology: From over-promising to a reality check

Almost five years ago, the plan to implement a wide-ranging digital pathology approach across the Netherlands began to take shape. As more labs across the country acquire digital pathology capability, with steps to create a strong and accessible image repository and a national image exchange platform, one of the project leaders, Professor Katrien Grünberg, offered an update and spoke of some…

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A more integrative approach to digital pathology

imCMS: The door to simple, cheap, reliable bio-stratification

Bringing molecular and digital pathology closer together through a more integrative approach can lead to clear advantages for diagnostic and research workflows. During the recent Digital Pathology and AI Congress (London) and in his keynote presentation ‘Molecular and digital pathology - the value of an integrative approach’ Professor Viktor Koelzer explored the benefits and paid particular…

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Tools for practitioners

Computational pathology: Heading for personalised medicine

Computational pathology has increased applications for diagnosis, prediction of prognosis and therapy response, facilitating the movement of healthcare towards personalised medicine. Coupled with deep learning, such tools are ever more efficient and robust within research and clinical settings. The growing role of computational pathology was highlighted by Professor Andrew Janowczyk at the…

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Digital pathology

COVID-19: Inspirata launches remote pathology resource

Hamamatsu and KiKo Knowledge Hub Join Inspirata’s Initiative to Offer Free Remote Pathology Solution for Healthcare Institutions Affected by COVID-19. Inspirata gains strategic support in its initiative to allow pathology departments across the world to offer work-from-home opportunities for their pathologists during the COVID-19 pandemic crisis.

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Integrated diagnostics

Radiologists, pathologists and geneticists gather around a digital table

Radiology, pathology, medical genetics and laboratory medicine under one roof: many hospitals are toying with the idea of ‘integrated diagnostics’ but it was the medical management at Geneva’s University Hospital that dared to take the first step and consolidate all these diagnostic disciplines in a single organisational unit: The Diagnostic Department. ‘Our long-term vision is a…

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On the way to diagnostic mainstream

Liquid biopsy to advance cancer diagnosis

Liquid biopsy offers a new dimension to detection and stratification of cancer – yet the technique also faces hurdles and challenges in becoming a mainstream diagnostic approach that will help facilitate more personalised treatments. A critical challenge lies in identifying the extremely low concentrations of the bio-analytes of CTC (circulating tumour cells), ctDNA (circulating tumour DNA) and…

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Digitizing workflows

Dutch hospital expands imaging solution to include digital pathology

Medical imaging IT and cybersecurity company Sectra has signed a digital pathology contract with the Dutch hospital Zuyderland MC. A digital pathology workflow makes it possible to access and share images and information between departments and hospitals. Storing, reviewing and sharing digital pathology images increases efficiency in primary diagnostics and improves cancer care by facilitating…

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TAITRA at Medica 2019

A vision of Taiwan innovation

A popular proverb in Mandarin goes ‘Hearing something a hundred times is not as good as seeing it once’ (百聞不如一見). Visiting the Taiwan pavilion at this year’s Medica, it’s clear to see that the Bureau of Foreign Trade (MOEA) from Taiwan, together with the Taiwan External Trade Development Council (TAITRA) and its foster companies, have taken this sentiment to heart. Seeing…

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TMAs in digital pathology

Infusing tissue micro­arrays with new, 'digital' life

The advent of digital pathology is helping to address some of the challenges surrounding tissue microarrays as they are integrated into the digital workflow, in some ways giving them ‘a new lease of life’, according to Professor Inti Zlobec, who spoke at the Digital Pathology and AI Congress in London last December. As Head of the Translational Research Unit at the Institute of Pathology,…

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Workforce challenges

Pathologists will hold a pivotal role

Amid ever-growing demand for services, significant challenges face the pathology workforce in the years ahead but – there are also good opportunities. With advances in technology and the advent of artificial intelligence as a decision-making support tool, Professor Jo Martin, President Royal College of Pathologists (RCPath) in the UK, believes there remain opportunities for pathology to play a…

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A STAMP with high value

New tech makes biopsies less invasive, more informative

A team of researchers has developed a novel technology that could sensitively and accurately detect and classify cancer cells, as well as determine the disease aggressiveness from the least invasive biopsies. With this new technology called STAMP (Sequence-Topology Assembly for Multiplexed Profiling), comprehensive disease information can be obtained faster, at a much earlier stage of the…

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Multiscale integrative cross-disciplinary imaging

Linking pathology and radiology workflows

Pathologic-radiologic correlation is already utilised in various settings as a tool to assess the interpretive performance of imaging studies and identify radiologic features corresponding to histologic findings. However, correlative assessment is currently limited mainly to the fields of research and quality assurance, and is generally not a routine element of the radiologist or pathologist…

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Seeking the right questions

Developing algorithms to assist routine pathology

Artificial Intelligence (AI) is destined for a significant role in assessing histology data but the key to developing the necessary algorithms lies in data quality – rather than the quantity, according to Professor Jens Rittscher. He also warns that we are some distance from seeing AI replacing human pathologists in this scenario, primarily because presently the risks of automated…

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Process optimisation

The Lean concept in digital pathology

We talked to Dr Annika Blank, Consultant and Lean green belt, about eight-year experience with the concept and optimisation of processes, the implementation of digital pathology and a voice recognition system for patient management. "The biggest and most cost intensive step taken to optimise workflows was the refurbishment of our laboratory, which was completed in 2016. This allowed us to…

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Prostate cancer data

Mapping the inflammatory landscape

Image analysis of prostate cancer is a challenging area for clinicians. The disease shows a low mutation burden compared to melanoma and stomach cancer, for example, making morpho-molecular correlation more difficult, and there is often very low inflammation. With the role of tumour infiltrating lymphocytes in prostate cancer currently unclear – and with the advent of new approaches to prostate…

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Revolution through AI

Pixel analysis: the new era of digital pathology

As reporting workload for pathology departments continues to rise rapidly, artificial Intelligence solutions are set to play an increasing role in daily practice. In many pathology departments the annual number of cases has risen by around 2-4% but the slides produced has doubled in the last decade. Histopathologist Professor David Snead identified this phenomenon within his own centre in the…

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Urothelial carcinoma

AI assists in PD-L1 scoring

A new deep learning algorithm, which demonstrates the potential of artificial Intelligence (AI) to support pathologists, has been developed for PD-L1 scoring in tumour cells and immune cells in urothelial carcinoma samples. Speaking at the Digital Pathology and Artificial Intelligence Congress in London last December, Dr Michel Vandenberghe, from AstraZeneca, outlined how PD-L1 expression level…

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