Pathology

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Mass spectrometry goes handheld

A pen to pin down the fringes of cancer

Mass spectrometry is a powerful tool for analysing the molecular composition in a tissue sample, which is invaluable information during cancer surgery. However, mass spectrometers are complex and…

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Covid-19 and pathology

Lung cancer care across Europe affected by coronavirus pandemic

The impact the coronavirus pandemic has had on lung cancer patient care across Europe, and the contribution lung pathologists have made to a better understanding of Covid-19, were detailed during a…

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Disaster victim identification

Will CT scanning in post-mortem examinations mark the end of the scalpel?

Post-mortem CT (PMCT) increasingly supports pathologists, radiologists and forensic investigators particularly in cases of gunshot fatalities, mass casualties, decomposed and concealed bodies, fire…

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Histological grading assistance

AI improves precision in breast cancer diagnosis

Researchers at Karolinska Institutet have developed an AI-based tool that improves the diagnosis of breast cancer tumours and the ability to predict the risk of recurrence. The greater diagnostic…

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Aβ oligomers role in dementia

Alzheimer's: finding the cause of toxic clumps

Small aggregates of proteins known as Aβ oligomers are suspected as the main cause for the development of Alzheimer’s disease. However, it is not yet clear where and under what conditions these…

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Tissue dissection

World‘s first automated high throughput tissector launched

Molecular pathology company Xyall BV launches its Tissector High Throughput (HT) system for precision diagnostics. This is a world first – enabling high volume, molecular diagnostic laboratories to…

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Sample-to-answer workflow

Partnership for Covid-19 test solution

SpeeDx Pty, Ltd. and MolGen announced the signing of an agreement to collaborate on supply and distribution of clinical diagnostics products and instrumentation across Europe and Asia Pacific. The partnership links specimen handling, nucleic acid extraction, assay set-up, amplification, and results reporting in a seamless integration of the companies technologies. “This partnership capitalises…

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Products of the Month

Enhance your Microscopy Workflow

Did you know that changing microscopy camera can make a real difference to your microscopy workflow? Packed full of smart features to make your imaging faster and easier, Olympus’ new DP23 and DP28 (4K) cameras enable streamlined, comfortable sample analyses at the monitor and easier, smoother conferencing. Get the most out of the monitor view and discover the many benefits of the DP23 and DP28…

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Tau pathology in the brain

Defining the 4 subtypes of Alzheimer's

Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in Nature Medicine.

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Mass spectrometry analysis

Skin swabs can detect Covid-19

Skin swab samples analysed using mass spectrometry could be used to detect Covid-19 in patients, according to research conducted at the University of Surrey in the UK. Current Covid-19 testing is via a polymerase chain reaction (PCR) test, which involves taking a swab of the back of the throat and inside the nose, but the team from Surrey - working with Frimley NHS Trust and the Universities of…

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Mass spectrometry

"Protein fingerprint" rapidly identifies Covid-19 biomarkers

Researchers from Charité – Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes. It is faster and cheaper than a conventional blood count. To demonstrate the technique’s potential, the researchers used blood plasma collected from Covid-19 patients.…

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Non-invasive corona breath testing

SpiroNose: The electronic nose that knows about Covid-19

Rapid tests, PCR tests, self-tests… there are many test options to determine contamination with Covid-19. In most this is done by inserting a cotton swab deep into the nose and/or throat to extract some mucus – unpleasant for adults and often a drama for children. Towards the end of 2020, a new system emerged to rule out a Covid-19 contamination. The electronic SpiroNose performs a…

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Brain tumour analysis

Glioblastoma '3D maps' help find new therapies

Researchers at the Universitat Autònoma de Barcelona obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies.

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Integrated diagnostics

Joining radiology and pathology solutions

Medical imaging IT and cybersecurity company Sectra has received an order for its digital pathology solution from Amsterdam UMC in the Netherlands. This follows a recently announced radiology imaging contract. With radiology and pathology in one joint solution, Amsterdam UMC will be able to conveniently share images and information between the two medical specialties, enabling efficient…

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Diagnosing SARS-CoV-2

The arsenal: Molecular (PCR), antigen and antibody testing

Germany’s lack of diagnostic ability led to significantly underestimation of its own as well as global Covid-19 infection levels during the first wave. Now, however, improved testing and diagnosis of the condition more realistically reveal nearer 20,000 new cases a day across the country, according to Professor Hendrik Streeck, one of the country’s leading virologists. Speaking at a virtual…

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Profiling the coronavirus

Experts unlock Covid-19 secrets

Experts have identified two distinct immunological and cellular profiles in the lungs of Covid-19 patients which they believe could help define treatment pathways. From some of the earliest Covid-19 autopsies conducted in Europe, Swiss-based researchers have performed integrative digital pathology and transcriptomic analyses of lung tissues of 16 coronavirus patients who died from respiratory…

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Using virus particles in exhaled breath

New SARS-CoV-2 test to deliver results in under 5 minutes

Research and innovation hub Imec announced that it has started developing a groundbreaking SARS-CoV-2 test. Unlike current approaches (using blood, saliva, or a nasopharyngeal swab), the new test will identify SARS-CoV-2 virus particles in a person’s exhaled breath. The solution promises the accurate identification of a contagious case in less than five minutes.

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Need for modernisation

Digital pathology: Luxury or necessity?

The anatomical pathologist faces a crisis. Public and private labs suffer increasing caseloads, whilst pathologist numbers diminish for various reasons, including greater cancer prevalence associated with aging populations as well as improved cancer screening programs. Precision medicine typically involves more genetic testing and extensive use of immunohistochemistry to classify cancer and…

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High-capacity digital image analysis

Spatial statistics extract subvisual features

Spatial analytics offers greater clarity in the assessment of tumours beyond routine microscopic analysis. High-capacity digital image analysis enables new methods of spatial statistics to extract features not immediately distinguishable by visual inspection. These subvisual features reflect complex properties, such as intratumour heterogeneity and have the additional benefit that they can target…

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Overcoming the barriers to AI in digital pathology

‘You can’t do AI on glass slides’

As Artificial Intelligence continues to impact on the development of digital pathology, potential users are still slow to implement key enabling technologies to harness the benefits, according to Dr David McClintock, who will detail critical steps for pathology departments to transition practice from glass (analogue) to digital (whole slide imaging) and embrace AI, to the 6th Digital Pathology…

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Tissue analysis

Infrared spectroscopy as a diagnostic tool

New techniques of infrared-based technology are showing strong potential for cost-effective tissue analysis. Peter Gardner, Professor of Analytical and Biomedical Spectroscopy at the University of Manchester, outlined how hyperspectral imaging coupled with sophisticated computer algorithms can identify and grade cancerous tissue, as well as offer an indication of prognosis. The technique, he…

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Histology/cytology equipment

Optimise pathology workflow with Hamamatsu whole slide imaging solutions

Hamamatsu Photonics understand the benefits and challenges of whole slide imaging systems. For over 15 years, we have been working to deliver robust and reliable scanners with optimal image quality. Our NanoZoomer whole slide scanner series quickly transform entire histology and cytology glass slides into diagnostic-quality digital images for duplication, annotation, storage, retrieval, and image…

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