Pathology

News • Viral persistence in the brainstem

Long Covid: Researchers find clues for "brain fog" origin

After an infection with the coronavirus Sars-CoV-2, the virus is able to persist at low levels in the brainstem, new research finds. This helps explain some of the enduring neurological symptoms.

News • Assessment of tumour-infiltrating lymphocytes

Skin cancer: AI assistance helps pathologists identify melanoma

More consistent TIL assessments, more accurate patients' prognoses: New research shows how AI sharpens pathologists' interpretation of tissue samples for malignant melanoma.

News • MRD assessment

Liquid biopsy to detect breast cancer relapse up to 5 years in advance

Newly developed technology can detect breast cancer relapses up to five years in advance. This advance could represent a turning point in post-treatment follow-up, the researchers hope.

News • Amyotrophic lateral sclerosis

New insights on ALS onset opens paths to earlier treatment

New research shows that dysfunction in the mitochondria linked to amyotrophic lateral sclerosis (ALS) occurs before the cells show other signs of disease, which was not previously known.

News • Faster, more accurate treatment

Basal cell carcinoma: AI support for Mohs surgery

Dutch researchers have developed an AI tool to support Mohs surgery, a precise but time-consuming procedure to treat the most common form of cancer in the Netherlands: basal cell carcinoma.

News • Mechanopathology

'Dengue-on-a-chip' to study infection mechanisms

Due to the effects of climate change, dengue is spreading worldwide. Now, researchers have developed a 'dengue-on-a-chip' model that helps study the virus more effectively.

News • Double Stokes polarimetric microscopy

New method to help accelerate cancer diagnosis

A new method to quickly and accurately analyze the structure of collagen in tissue shows promise to improve the diagnostics of cancer and other diseases.

Article • Digital pathology discussion panel

The AI tools pathologists want and need

The evolving role of AI tools in digital pathology was explored at an open discussion during the annual Digital Pathology and AI Congress in London with a high-level panel of practitioners looking at current and future technology options. The panel of pathologists, scientists and academics from Europe and the USA assessed the tools they currently use and are available to them, and those they…

News • Machine learning analysis

Breast cancer: AI predicts metastasis from recurrence

The location and timing of breast cancer recurrence may allow AI to predict the risk of metastasis, a new study shows. This is an essential step towards developing personalised treatment strategies.

Connect, automate and innovate your lab through SMART Automation 

In today’s fast-paced healthcare landscape, efficiency and accuracy are essential in overcoming workload challenges. Pathology laboratories are under pressure to keep up with growing demands, all while ensuring standardised, consistent and high-quality results. 

News • Intrinsic electrical activity drives cancer progression

SCLC: Deciphering the unusual aggressiveness of small cell lung cancer

New research reveals that self-generated electrical activity of small cell lung cancer (SCLC) directly promotes tumor metastasis and progression. This may provide new avenues for future treatments.

News • Circulating tumor DNA analysis

Liquid biopsy helps reduce chemotherapy in colon cancer patients

For patients, a liquid biopsy which checks for circulating tumour DNA of colon cancer, resembles a standard blood test. However, the method helps avoid chemotherapy for many, a new study finds.

Article • Detection of neurodegenerative condition

Developing blood biomarkers to diagnose Alzheimer’s disease

There is no known cure for Alzheimer’s disease (AD), although prescription drug-based treatments that can slow AD progression in some patients are starting to enter clinical use. Biomarkers, quantifiable characteristics of biological processes or pathological conditions of the body, are making it possible to help identify and measure the presence and extent of AD and its degenerative…

Article • Promising, but in need of further validation

Implementation challenges of blood biomarkers for Alzheimer’s disease

Blood-based biomarker (BBB) tests may represent the best weapon to combat the soaring rates of Alzheimer’s disease (AD) throughout the world. Existing clinically validated tests are currently deployed to facilitate diagnosis, to monitor disease and effectiveness of treatments, to quantify progression, and to determine if a patient is appropriate for treatment or participation in a clinical…

News • Deep and ensemble learning improve performance

New AI tool surpasses previous methods in colorectal cancer tissue analysis

Researchers developed an advanced AI tool for automatic analysis of colorectal cancer tissue slides. The new model outperformed all predecessors in the classification of tissue microscopy samples.

News • Cell-free tumor DNA analysis

Liquid biopsy to unlock breast cancer treatments

New research highlights the potential of circulating tumor DNA (ctDNA) analysis as a non-invasive method to identify actionable biomarkers for breast cancer, enabling individualized therapies.

News • Study explores impact

How brain trauma can trigger Alzheimer's disease

Traumatic brain injury (TBI) increases dementia risk, but the reasons are poorly understood. Now, a study explores the role of the brain's blood vessels as drivers of Alzheimer's disease.

News • Reactive glial responses

Mapping the brain's self-healing ability after stroke

Helping the brain repair itself after a stroke: A new study based on unique tissue samples from Denmark's Brain Bank may pave the way for new treatments that support brain regeneration.

News • Promising prototype

A “diagnostic wand” to detect oral cancer

Liverpool physicists have developed a “diagnostic infrared wand” to more accurately predict the prognosis of oral cancer lesions than current H&E staining techniques.

Article • Keynote on integrated diagnostics

Predicting – and shaping – the future of modern pathology

Complex diseases could require complex biomarkers for accurate diagnosis in the years ahead, according to a leading pathologist. In a keynote address to the 36th European Congress of Pathology in Florence, Italy, Professor Manuel Salto-Tellez highlighted this as one of the major future challenges for the discipline. However, he also believes pathologists will sit at the core of modern medicine.

News • Advances in precision medicine

MASLD: Research reveals two types of fatty liver disease

Metabolic-associated fatty liver disease has 2 types – a liver-specific type and a systemic type that affects other organs and tissues. This discovery could lead to better diagnosis and treatments.

MEDIPATH makes a step towards lab automation with the help of Sakura Finetek Europe

Sakura Finetek Europe and MEDIPATH, a group of independent French pathologists, announced their collaboration to enhance cancer diagnostics and thus contribute to improved patient therapeutic management. This decision is part of an ongoing commitment to improving the quality of care provided to patients and in response to the significant increase in cancer cases over the last years.

News • Tumour movement across tissues

Understanding metastasis: migration strategies of ovarian cancer

A new study shows how inherent variations in a cancer cell and its interactions with its surroundings mould its migration. The findings provide valuable insights into the processes behind metastasis.

Article • Between good practice and financial pitfalls

Delivering molecular pathology at lower costs

Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.

Article • Transformative technology

Debating the case for AI in pathology

Artificial Intelligence (AI) remains a divisive topic within the discipline of pathology with a range of opinions over its current value and applicability in clinical settings. While most experts agree that the technology will not replace pathologists, it might still spell bad news for those who do not embrace AI in their daily practice. On the other hand, reservations persist about whether…

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