Research

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Neurology

The 'thermostat' that prevents our brain from overheating

The mechanisms by which the body measures temperature and regulates its own body heat are vital, but still poorly understood. The discovery of the first heat sensor on nerve cells in the skin, for…

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Resistance mechanism discovered

How staphylococci protect themselves against antibiotics

The skin bacterium Staphylococcus aureus often develops antibiotic resistance. It can then cause infections that are difficult to treat. Researchers at the University of Bonn have uncovered an…

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Successful investigational procedure

First ever pig-to-human kidney transplantation shows promise for organ replacement

The first investigational transplantation of a genetically engineered, nonhuman kidney to a human body was recently completed at NYU Langone Health—marking a major step forward in potentially…

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Brain stimulation

Infrared light helmet might aid dementia patients

Researchers at Durham University are working on a new infrared light therapy that might have the potential to help people with dementia. In the approach, people wear a specially adapted helmet which…

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Anemic alternatives

'Bloodless' transfusion could solve global blood shortage

Blood transfusions save lives, yet the precious fluid is in desperately short supply around the globe. But what if transfusions don’t always require blood? A new mathematical model of the body’s…

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'CRyPTIC' research

Global tuberculosis study identifies genetic causes of drug resistance

Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common…

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ECG computation

Energy-efficient AI detects heart defects

Researchers at the national research institute for mathematics and computer science in the Netherlands (CWI), together with a colleague from Stichting Interuniversitair Micro-Elektronica Centrum (IMEC) in Eindhoven, have achieved a mathematical breakthrough in the computation of so-called spiking neural networks. Thanks to this breakthrough, special chips that are suitable for this artificial…

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Coronavirus inhibition

Highly potent antibody against SARS-CoV-2 discovered

Scientists at Lausanne University Hospital (CHUV) and École polytechnique fédérale de Lausanne (EPFL) have discovered a highly potent monoclonal antibody that targets the SARS-CoV-2 spike protein and is effective at neutralizing all variants of concern identified to date, including the delta variant. Their findings are published in the journal Cell Reports.

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Cancer research

How to break through a tumor's protective shield

The immune system protects the body from cancer. To protect healthy body cells from its own immune system, they have developed a protective shield: the protein CD47 is a so called "don’t eat me" signal, which tells the immune cells to stand back. Tumor cells exploit this CD47-based protection strategy for evading the immune system, by increasing presentation of CD47 on their cell…

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Genomic tracking

Retracing the Covid-19 pandemic in England

The Covid-19 crisis that gripped England between September 2020 and June 2021 can be thought of as a series of overlapping epidemics, rather than a single event, say researchers at the Wellcome Sanger Institute, EMBL's European Bioinformatics Institute (EMBL-EBI) and the German Cancer Research Center. During this period, the country wrestled with multiple variants of the SARS-CoV-2 virus that…

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3D microelectrodes

Promising approach for pain relief without side effects

Researchers at Lund University in Sweden have developed a completely new stimulation method, using ultra-thin microelectrodes, to combat severe pain. This provides effective and personalised pain relief without the common side effects from pain relief drugs. The study, which was conducted on rats, has been published in the research journal Science Advances.

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microRNAs hint at cognitive decline

Researchers find warning signs for dementia in the blood

esearchers at the DZNE and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. Their findings, which are presented in the scientific journal “EMBO Molecular Medicine”, are based on human studies and laboratory experiments. Various university hospitals across Germany were also involved in the investigations.

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Immune response study

Is a "natural" Covid-19 infection better than vaccination? It's complicated

Hope for a future without fear of Covid-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades. And they evolve over time, learning to produce successively more potent “memory antibodies” that are better at…

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Incubator 2.0

Artificial uterus improves odds for preemies

“An artificial uterus – the incubator 2.0 – will become a reality within 10 years,” says Jasmijn Kok, one of the founders of Juno, a spin-off from the Eindhoven University of Technology, Netherlands. Together with researchers from the department of Industrial Design from the University, including her twin sister Lyla Kok, she wants to bring a technology that increases the chances of…

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Immunological memory

How our lungs 'remember' a Covid-19 infection

After infection with SARS-CoV-2, where does the immune system store the memory to provide long-term protection against reinfection? Though numerous studies have examined blood to track immune responses to SARS-CoV-2, a new study of Covid survivors shows that the memory of the infection is primarily stored in T and B cells within the lung and the lymph nodes surrounding the lung.

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Cardiology research

Transcatheter aortic valve replacement: new insights on life expectancy

Researchers at Karolinska Institutet have examined long-term outcomes in patients who received pacemaker implantations after transcatheter aortic valve replacement (TAVR) through their groin. The result showed no significant difference in mortality for the patients with pacemakers compared to those without. The study is published in the journal JACC: Cardiovascular Interventions.

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Organoid research

Structure formation in mini-organs

Many of the organ systems found in animals exhibit highly complex structures, which are essential for their various functions. How such structures develop during embryonic development is a central question in biology. Physicists led by Erwin Frey (Professor of Statistical and Biological Physics at LMU Munich) and Andreas Bausch (Professor of Cellular Biophysics at the Technical University of…

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For discoveries of receptors for temperature and touch

Nobel Prize in Medicine goes to David Julius and Ardem Patapoutian

The Nobel Prize in Physiology or Medicine 2021 was awarded jointly to two scientists who made important discoveries regarding our receptors for temperature and touch. Our ability to sense heat, cold and touch is essential for survival and underpins our interaction with the world around us. In our daily lives we take these sensations for granted, but how are nerve impulses initiated so that…

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Scaffold-free approach

Researchers create cartilage tissue out of stem cells

Researchers at the University of Southampton have invented a new way to generate human cartilage tissue from stem cells. The technique could pave the way for the development of a much-needed new treatment for people with cartilage damage. Cartilage acts as a shock absorber in joints, but it is susceptible to damage through daily wear-and-tear, or trauma from sports injuries and falls.

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Tumor growth stopped in mice

Antidepressants show promise in cancer growth inhibition

Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term. In some cases the tumors disappeared completely, researchers at the University of Zurich (UZH) and University Hospital Zurich (USZ) have found. Their findings will now be tested in…

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