Machine learning
AI predicts which drug combinations kill cancer cells
Researchers in Finland have developed a machine learning model that can help us treat cancer more effectively.
Therapy
Commonly used antibiotic
Methacycline shows promise for combating Zika infections
In a preclinical study, NIH scientists found that the commonly used antibiotic methacycline may be effective at combating the neurological problems caused by Zika virus infections.
New mechanism of action
A small-molecule degrades a cancer-promoting
"Molecular glue degraders" are a new class of cancer drugs, which "glue" cancer growth-promoting proteins directly to the molecular machinery of a cell's disposal system, leading to the subsequent degradation of the cancer-driving proteins and anti-tumor activity. Scientists from Heidelberg and USA have now deciphered another mechanism whereby a small molecule can degrade a…
Intratumoral B cells
Another side to cancer immunotherapy?
Scientists report on their detailed look at B cells' presence inside tumors. B cells represent the other major arm of the adaptive immune system, besides T cells, and could offer opportunities for new treatments against some kinds of cancers.
Genome editing system
CRISPR-based treatment destroys cancer cells
Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer.
Immunotherapy, iRecist and complications
Lung cancer imaging (in a post-Covid world)
The evolving area of immunotherapies in lung cancer and the role of iRecist treatment assessment protocols were investigated during a virtual session organised by the British Institute of Radiology (BIR). Consultant radiologist Dr Charlie Sayer, specialist in lung cancer imaging at the Brighton and Sussex University Hospitals Trust, South of England, focused on immunotherapies, the limitations of…
Finding therapeutic targets
Pancreatic cancer: Seeking viable treatment strategies
Pancreatic cancer has the worst survival rate of any cancers, with immunotherapies currently offering negligible treatment benefits for patients. To help identify new therapeutic approaches, researchers from the University of Oxford have been focusing on leukocyte infiltration as a prognostic marker of the disease. Their study and findings were outlined by Dr Shivan Sivakumar during a session…
Immunotherapy side effect
Hope for kidney cancer patients
An autoimmune side effect of immune checkpoint inhibitor (ICI) drugs could signal improved control of kidney cancer, according to a new study by researchers in UT Southwestern's Kidney Cancer Program (KCP).
treatment sensitivity
Single brain region links depression, anxiety and heart disease
Over-activity in a single brain region called the subgenual anterior cingulate cortex (sgACC) underlies several key symptoms of mood and anxiety disorders, but an antidepressant only successfully treats some of the symptoms. A new study suggests that sgACC is a crucial region in depression and anxiety, and targeted treatment based on a patient's symptoms could lead to better outcomes.
Trial finds limited effectiveness
COVID-19: plasma from recovered patients not as effective as hoped
Convalescent plasma shows limited effectiveness as a potential treatment for patients with COVID-19 to help them fight off the infection, finds a clinical trial from India published by The BMJ. The findings show that convalescent plasma fails to reduce mortality or stop progression to severe COVID-19.
Improved patient response
Existing heart drugs may help with PD(L)1 immunotherapy
Researchers have found that a class of commonly-used heart drugs may also improve patients’ responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. Angiotensin receptor II blockers (ARBs) are often prescribed for high blood pressure, heart failure,…
Therapy development
New approach to 'BEAT' COVID-19
The present Coronavirus pandemic with all its effects on society – both health and economic – highlights the urgency of developing new therapies for COVID-19 treatment. At the same time, it demonstrates the necessity to become well prepared for new virus infections we may be facing in the future. To help control the current pandemic and brace for novel pathogens that may cause future…
List by top clinicians and researchers
Top 10 medical innovations for 2021
An up-and-coming gene therapy for blood disorders. A new class of medications for cystic fibrosis. Increased access to telemedicine. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of clinicians and researchers from Cleveland Clinic. In conjunction with the 2020 Medical Innovation Summit, Cleveland Clinic…
Exploring new principles for therapeutic agents
New class of inhibitors to protect against neurodegeneration
Neurobiologists at Heidelberg University have discovered how a special receptor at neuronal junctions that normally activates a protective genetic programme can lead to nerve cell death when located outside synapses. Their fundamental findings on neurodegenerative processes simultaneously led the researchers at the Interdisciplinary Center for Neurosciences (IZN) to a completely new principle for…
Interrelationship
Impact of COVID-19 on cancer treatment
The COVID-19 pandemic has impacted virtually every aspect of cancer care and research– from introducing new risks for cancer patients to disrupting the delivery of cancer treatment and the continuity of cancer research.
Coronavirus
Discovery of four COVID-19 risk groups helps guide treatment
An easy-to-use score for predicting risk of death in adult patients admitted to hospital with covid-19 outperforms existing scores and can be used to support treatment decisions, finds a study published by The BMJ today.
Atrial fibrillation ablation
Superfast procedure to treat heart arrhythmia
A new procedure to correct atrial fibrillation (AF) has been performed for the first time in the UK last week at Leicester's Hospitals. AF affects 1-2% of the general population, which amounts to more than 1 million people in the UK, and increases the risk of stroke by five times. Treating the condition with medicine is often ineffective, with many patients continuing to suffer from…
Weaning from respiration
COVID-19: novel Diaphragm Therapy shows promise
Department B for Internal Medicine of the University Medical Center Greifswald successfully used, within an international multi-center trial, a special diaphragmatic stimulation therapy to treat a COVID-19 patient as the first clinical site in Europe. "The first patient treated in this trial happened to be a woman who survived COVID-19, but was not able to be weaned from mechanical…
Ophthalmology
Nanoparticles for gene therapy cure eye diseases
Johns Hopkins scientists report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye.
Tailor-made therapies
Diabetes care enters precision medicine
A new joint report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) presents the largest venture ever on precision medicine in diabetes. The report includes a detailed overview and roadmap for how this new approach to diabetes medicine can be evaluated and implemented into clinical practice.
Fluoxetine
Antidepressant inhibits coronavirus
A standard drug for the treatment of depression might also be effective against Covid-19, a new study by Würzburg scientists shows which has been published on a preprint server
Neuro-Imaging
Advanced MRI scans may improve treatment of Parkinson's disease
Recently developed MRI techniques used to more precisely target a small area in the brain linked to Parkinson's disease and essential tremor may lead to better outcomes without surgery and with less risk of negative effects, a new study led by UT Southwestern researchers suggests.
Reversing incurable cause for blindness
Macular degeneration: Gene therapy restores vision
Macular degeneration is one of the major reasons for visual impairment, round the globe, close to 200 million people are affected. It damages the photoreceptors in the retina, which lose their sensitivity to light. This can lead to impaired vision or even complete blindness. Scientists at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) together with colleagues from the German…
New gene therapy approach
Tumor-tropic technology for targeted cancer therapy
Toshiba Corporation and a team led by Professor Yozo Nakazawa at the Department of Pediatrics, Shinshu University, have together developed a “tumor-tropic liposome technology” for gene therapy. The technology uses unique, nano-sized biodegradable liposomes developed by Toshiba to accurately and efficiently deliver therapeutic genes to targeted cancer cells, and achieves safer gene delivery…
Post-intensive care syndrome (PICS)
How physical therapists can aid COVID-19 patients' recovery after ICU
At least half of all patients who survive treatment in an intensive care unit will experience at least one of a triad of problems associated with post-intensive care syndrome, or PICS, and this may be true for people recovering from COVID-19 following ICU care. PICS can manifest as problems with physical function, cognition and mental health, according to a fact sheet from the American Thoracic…