Cells

Photo

Detection and diagnosis of cancer

The ‘smart’ future of cytology

A combination of digital pathology and quantitative biomarker analysis in the emerging concept of ‘smart’ cytology has a potential role in the detection and diagnosis of cancer.

Photo

Additive manufacturing

3D printing testicular cells

In a pair of world firsts, scientists have 3D printed human testicular cells and identified promising early signs of sperm-producing capabilities.

Photo

Impaired proliferation and induced cell death

Newfound mechanism could stop cancer cells in their tracks

Researchers have identified a mechanism that impairs the proliferation of cancer cells and induces their death without affecting healthy cells. This could lead to improved cancer treatment.

Photo

Kinematic self-replication

Xenobots: first living robots that can reproduce

AI-designed Xenobots reveal an entirely new form of biological self-replication—promising for regenerative medicine.

Photo

New AI reveals

What is in our cells?

Artificial intelligence-based technique reveals previously unknown cell components that may provide new clues to human development and disease.

Photo

New cause for tumor spread found

Blood vessels produce growth factor that promotes metastases

Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have identified a new growth factor produced by blood vessels that enables tumor…

Photo

Coronavirus medication research

Lab-grown beating heart cells could identify Covid drugs

Scientists have grown beating heart cells to attempt to identify drugs to prevent Covid-19-related heart damage. Concerns over the extent of cardiac damage among Covid patients emerged during the coronavirus pandemic and there are also suggestions that the impact on cardiomyocytes could contribute to the symptoms of long Covid. To explore these issues, a research team at the University of…

Photo

Research on after-effects

Viruses leave traces long after the infection is over

Viruses do not always kill the cells they infect. Researchers at the University of Basel have discovered in experiments with mice that cells have the power to self-heal and eliminate viruses. However, these cells undergo long-term changes. The findings may provide a hint as to why cured hepatitis C patients are more susceptible to liver cancer for years after.

Photo

Cell delivery vehicles

Bio-inspired nanocontainers could enter cells and release their medical cargo

Nanocontainers can transport substances into cells where they can then take effect. This is the method used in, for example, the mRNA vaccines currently being employed against Covid-19 as well as certain cancer drugs. In research, similar transporters can also be used to deliver labelled substances into cells in order to study basic cellular functions. To take advantage of their full potential,…

Photo

Promising research tool

World's first digital cancer cell model

Computer models have been standard tools in basic biomedical research for many years. However, around 70 years after the first publication of an ion current model of a nerve cell by Hodgkin & Huxley in 1952, researchers at Graz University of Technology (TU Graz), in collaboration with the Medical University of Graz and the Memorial Sloan Kettering Cancer Center in New York, have finally…

Photo

Building a coronavirus factory

How SARS-CoV-2 reprograms human cells to their own benefit

Coronavirus researchers under Prof. Rolf Hilgenfeld of the University of Lübeck and Dr. Albrecht von Brunn of the Ludwig-Maximilians University of Munich discovered how SARS viruses enhance the production of viral proteins in infected cells, so that many new copies of the virus can be generated. Other coronaviruses apart from SARS-CoV and SARS-CoV-2 do not use this mechanism, thereby providing a…

Photo

Mitochondria research

Colorectal cancer: Mutations in overlooked DNA could have huge impact on survival

DNA errors in the cell’s energy ‘factories’ increases the chances of survival for people with bowel cancer, also known as colorectal cancer, according to a new study. Studying how DNA errors (mutations) can drive cancer development, as well as help it adapt and evolve, has been a key focus of cancer research. But much of that focus has been on DNA found in the cell’s nucleus. Experts say…

Photo

Uprooting cancer

New hydrogel 'reprograms' cancer cells back to cancer stem cells

An innovative hydrogel – called a double network (DN) gel – can rapidly reprogram differentiated cancer cells into cancer stem cells, researchers at Hokkaido University and the National Cancer Center Research Institute have reported in the journal Nature Biomedical Engineering. The hydrogel can be used to help develop new cancer therapies and personalized medicines targeting cancer stem cells.

Photo

Acidity analysis

Harnessing AI to identify cancer cells

Healthy and cancer cells can look similar under a microscope. One way of differentiating them is by examining the level of acidity, or pH level, inside the cells. Tapping on this distinguishing characteristic, a research team from the National University of Singapore (NUS) has developed a technique that uses artificial intelligence (AI) to determine whether a single cell is healthy or cancerous…

Photo

Collagen 'pushing'

Supercomputer illustrates mechanical process of cancer growth

According to the World Health Organization, one in six worldwide deaths have been attributed to cancer; however, these fatalities were not due to initial malignant tumors—the deaths were caused by the spread of cancer cells to surrounding tissues and subsequent tumor growth. These tissues, which consist largely of collagen, have been the focus of a recent collaborative study by a team from…

Photo

Multiphoton microscopy gives new insights

Microscopic behaviour of developing breast cells uncovered

An improved high-tech fluorescence microscopy technique is allowing researchers to film cells inside the breast as never seen before. This new protocol provides detailed instructions on how to capture hi-res movies of cell movement, division and cooperation, in hard-to-reach regions of breast tissue. The technology – called multiphoton microscopy – uses infrared lasers to illuminate…

Photo

Physics of tumours

How cancer cells shape-shift to squeeze through tissue

Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. In experiments, the team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumour tissues and squeeze past neighbouring cells. The…

Photo

Target cells, medication effects, evasion methods

4 new facts about early Covid-19 infections

University of Minnesota Medical School researchers studied SARS-CoV-2 infections at individual cellular levels and made four major discoveries about the virus, including one that validates the effectiveness of remdesivir – an FDA-approved antiviral drug – as a form of treatment for severe Covid-19 disease. “Since the start of the Covid-19 pandemic, the way that each individual responds…

Photo

CARS & multiphoton microscopy

Multimodal imaging to detect cancerous cells faster and more accurately

Improving the detection of cancerous cells during surgery – this is the goal of the European research project CARMEN. The research institutes Laser Zentrum Hannover e.V. (LZH) from Germany and Multitel asbl from Belgium work together with companies from both countries, JenLab GmbH, Deltatec, and LaserSpec, to develop a novel, compact and multimodal imaging system. This could even allow the…

Photo

SARS-CoV-2 vs the proteome

Researchers explore coronavirus interactions with cells

Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments. SARS-CoV-2 infections pose a global threat to human health and a formidable research challenge. One of the most urgent tasks is to gain a detailed understanding of the molecular interactions between the…

149 show more articles
Subscribe to Newsletter