Prostate cancer

Prostate cancer (PCa) is not only one of the most common, but also one of the deadliest types of cancer in men. Diagnostics are correspondingly sophisticated, from imaging via ultrasound or MRI to various biopsy techniques – often even in combination. Keep reading for current developments in early detection, staging, therapy and research.

News • Gesture sequence recognition and clinical outcome prediction

Prostate cancer: AI analyzes surgical technique to improve care

A newly developed AI system analyzes surgeons’ techniques during prostate cancer surgery, helping identify the surgical movements associated with the best patient outcomes.

News • After an initial negative scan

Treatment change for prostate cancer: study reveals benefit of second PSMA PET

A second prostate-specific membrane antigen (PSMA) PET scan changed treatment plans for nearly half of prostate cancer patients whose first scan was negative, according to new research.

News • Exploring the landscape of tumour methylation

Parsing the pathology of prostate cancer

Why do some prostate cancers grow slowly and remain localized while others become aggressive and metastasize? In a new paper, researchers identify the answer: tumor methylation.

News • Comparison study

Prostate cancer screening on par with breast cancer screening

Prostate cancer screening compares favourably to screening for breast cancer in identifying significant cancers, reducing mortality and avoiding unnecessary harms, says new research.

News • Nuclear imaging in urology

Prostate cancer: PSMA PET/CT could cut need for biopsies

A PSMA PET/CT imaging test could safely halve the number of people who need a biopsy for suspected prostate cancer following inconclusive or reassuring results from an MRI scan, new research finds.

News • Adaptive re-planning

Repurposed radiotherapy scans to guide prostate cancer treatment

Radiotherapy is effective against prostate cancer but can cause side effects. Using AI, scientists found that images originally taken to help position patients could also predict rectal bleeding.

News • New targetable driver of growth found

Thyroid gland: unexpected key to prostate cancer treatment

An international research team has discovered a promising new therapeutic approach for aggressive prostate cancer – in the thyroid gland.

Interview • Shift from biopsy to imaging

How MRI-first diagnostics are transforming prostate cancer care

Magnetic resonance imaging (MRI) holds great potential to spare men with suspected prostate cancer a painful biopsy. In our interview, Dr. Peter Seidensticker, Head of Medical Affairs Radiology at Bayer, outlines how MRI could be implemented as a first-line diagnostic.

News • New imaging solution

PSMA PET to detect prostate cancer recurrence

A novel imaging solution, called PSMA PET scanning, can more effectively detect the recurrence of prostate cancer compared to standard methods, and is associated with improved survival outcomes.

News • Nuclear imaging

Prostate cancer: High-speed whole-body SPECT tracks tumor evolution

A new type of SPECT imaging provides strong prognostic information to guide prostate cancer treatments according to tumor evolution, significantly impacting patients' overall survival.

News • Prediction of treatment sensitivity

Personalising prostate cancer treatment through molecular testing

A new study shows that a gene expression test on routinely collected prostate tissue can help guide therapy choices for prostate cancer patients whose cancer has spread to other parts of the body.

News • Discovery of tumour indicating morphological changes

Prostate cancer: AI finds changes missed by pathologists

Men assessed as healthy may still have an early form of prostate cancer. Using AI, researchers found signs that were missed in more than 80% of samples of men who later developed cancer.

News • Fluorescent 18F-PET imaging

Dual-mode PET tracer lets surgeons see – and hear – prostate cancer

Tracer molecules serve to provide visual guidance in nuclear medicine, but a new molecule could give surgeons additional audio cues to help them locate prostate cancer tumors and metastases.

News • Risk of misclassification

Prostate cancer: why “low-grade” might not be “low risk”

Classifying prostate cancer as “low-grade” could create a false sense of security and delay definitive treatments. A new study shows that the biopsy grade alone can paint an incomplete picture.

News • Adherence to recommended treatments

Prostate cancer guidelines improve outcomes, study finds

From active monitoring to combinations of local and systemic treatment: A new study shows that most men with prostate cancer who receive treatment recommended by guidelines have a good prognosis.

Daniela Oprea-Lager

Pushing the boundaries of theranostics

Nuclear medicine specialist Daniela Oprea-Lager has been appointed Professor of Theranostics at Radboudumc / Radboud University. Her research focuses on the combination of diagnostics and treatment using radioactive substances, with particular interest for urological tumors, especially prostate cancer.

News • Combining spatial transcriptomics, pseudotime and machine learning

More precise than PSA: New biomarkers for prostate cancer found in urine

Using AI and extensive analyses of gene activity in tumours, researchers have found new, precise biomarkers to diagnose prostate cancer at an early stage through a simple urine sample.

News • Lifestyle-related disease prevention

Soccer: an underrated champion of global health

Soccer is not only a fun and popular sport, but can also help prevent many lifestyle-related conditions, including diabetes, heart disease, obesity, several cancers, and mental health challenges.

News • Alternative to MRI-guided biopsy

Micro-ultrasound to speed up prostate cancer diagnosis

To diagnose prostate cancer, an MRI-guided biopsy is often performed. Now, a study shows that micro-ultrasound is just as effective, cheaper and easier to use. This could help free up MRI capacities.

News • Research on RAD51 biomarker

Next-generation sequencing for personalizing prostate cancer treatment

Certain gene alterations can serve as a prognostic and predictive biomarker for prostate cancer. Now, researchers confirm the feasibility of using NGS on this marker for precise patient stratification and treatment selection.

News • Successful clinical validation

Urine-based test detects aggressive prostate cancer

Researchers have clinically validated a previously developed urine test for prostate cancer screening, which can potentially bypass invasive procedures among men who are unlikely to benefit.

News • Catheter-based approach

New method aims to "steam away" prostate cancer

Steam eliminates wrinkles and germs, but can it destroy cancer cells too? A multisite clinical trial explores the potential of a water vapor system using steam to kill prostate cancer cells.

News • Cancer treatment advances

USC study findings: early blood test forecasts survival rates in patients with metastatic prostate cancer

A new study found that measuring circulating tumor cells (CTCs), rare cancer cells shed from tumors into the blood, is a reliable way to predict later treatment response and survival prospects with metastatic prostate cancer.

News • Discussion on nomenclature

“Prostate cancer” or “incidentaloma”: What should early findings be called?

Certain early-stage changes to the prostate very rarely develop into aggressive cancer, but are still called that. Would it create a false sense of security to not call these “cancer” at all?

News • Quicker, cheaper and less painful test

Blood crystals to reveal early signs of prostate cancer

A new method of analysing the crystals in dehydrated blood could lead to a quicker, cheaper and less painful technique to diagnose, early detect, and monitor prostate cancer.

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