Stem cells

News • GATA2 deficiency

New gene-editing technology could help treat rare diseases

Researchers have successfully corrected part of a genetic defect in stem cells taken from a patient with GATA2 deficiency. This could have significant implications for patients with genetic disorders.

News • iPSC-derived assembloids

Heart valve organoid to advance understanding of cardiac conditions

In a first for the field, a team has grown heart valves on organoids. This work is an important step toward better understanding—and treating—a number of serious heart disorders.

News • Anti-inflammatory treatment

New therapy may reduce HF risk after heart attack

After a heart attack, a new type of treatment, administered directly into the damaged blood vessel, stimulates healing. This could help prevent heart failure due to scarring, the researchers say.

News • Minimally invasive stimulation

Microrobots repair spinal cord damage

A new approach to repair spinal cord injuries: A biohybrid robot combining therapeutic stem cells with magnetoelectric nanoparticles. First tests on zebrafish and mice show promise.

News • Combining stem cell therapy with surgery

Spina bifida: in-utero stem cell treatment approach shows promise

Combining stem cell therapy with standard fetal surgery before birth is a safe and promising approach to treat myelomeningocele, a severe form of spina bifida, a new study has shown.

News • Synthetic peptide hydrogels

Bioengineered bone marrow model advances leukaemia research

Using a bioengineered bone marrow model, researchers were able to provide key new information on the efficacy and safety of CAR T-cell therapy for acute myeloid leukaemia (AML), the most common…

News • Inclusion of all cell lineages

Advanced pancreas organoid for better insights

A new type of pancreas organoid contains all key pancreatic cell types - acinar, ductal, and endocrine cells - allowing valuable new insights.

News • Damage in vascular organoids

Lab-grown diabetic vessels give new insights

Using vascular organoids derived from stem cells, researchers gain new insights into how diabetes damages blood vessels. This could lead to to the development of new treatments.

News • Generation of alveolar epithelial type I cells

Study furthers understanding of lung regeneration

Researchers present a new method for generating human alveolar epithelial type I cells. This could ultimately progress therapies for people living with pulmonary diseases.

News • Stem cell research

Camouflaging transplants to avoid immune rejection

Researchers from the Chinese Academy of Sciences, Beijing, have genetically engineered stem cells so that liver cells obtained from them would be invisible to the immune system.

News • iPS cell-derived mesenchymal stem cells

Researchers discover new way to generate high-quality cartilage

A Japanese research group has developed a method using iPS cell-derived mesenchymal stem cells (iMSC) to create cartilage spheroids, offering new possibilities for tissue repair.

News • Prevention of blood cancer

Research identifies new target that may prevent blood cancer

An international coalition of biomedical researchers has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients' risk of blood cancer.

News • New treatment insights

Successful cure of HIV infection after stem cell transplantation

A new study confirms that haematopoietic stem cell transplantation can be used to cure patients with HIV infections. This third successful case gives new insights into the underlying processes.

News • Making tumours susceptible to chemo

Breast cancer: target protein may hold key to therapy success

A rare variant of a protein present in nearly all human cells may hold the key to improving the effectiveness of breast cancer treatment, according to University of Manchester research.

News • After blood stem cell transplantation

How the immune system "reboots" in MS patients

Blood stem cell transplantation is a radical but highly effective therapy for multiple sclerosis. A study examined how the treatment curbs the disease and how the immune system regenerates afterwards.

News • Insights into stem cell behaviour

Breast cancer: new mechanism of drug resistance discovered

Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.

Article • Modelling systems for human biology

Organoid technology: new opportunities for drug discovery

Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.

News • Customized to the patient

Organ-on-a-chip systems go 'plug and play'

A major advance demonstrates first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer.

News • Regenerative medicine

Injectable stem cell assembly for cartilage regeneration

Researchers have established an injectable hybrid inorganic nanoscaffold-templated stem cell assembly and applied it to the regeneration of critically-sized cartilage defects.

News • Artificial brains

Brain organoids help understand autism

Scientists use miniature brain models to understand how a mutated gene affects brain development.

News • Cancer research

Transparent ultrasound chip improves imaging

A biocompatible ultrasound transducer chip could be a more effective way to harness the technology for biomedical applications.

News • Bone marrow transplant

The impact of chemotherapy on the brain

Pre-transplant chemotherapy facilitates the replacement of the brain's innate immune cells, by other immune cells derived from the transplanted stem cells.

News • Cardiology insights

Lab-grown heart cells 'mimic' disease in vitro

Heart cells from a patient with an inherited heart disease called arrhythmogenic cardiomyopathy do not contract correctly when grown in the laboratory, researchers from Osaka University have found.

News • Intra-nasal administration

Microrobots for treating neurological diseases

The joint research team of Prof. Hongsoo Choi (DGIST) & Prof. Sung Won Kim (Seoul St. Mary’s Hospital), developed an hNTSC-based microrobot for minimally invasive delivery into the brain tissue via the intranasal pathway.

News • Irradiation

Adult stem cells transform faster with two lasers

Researchers from the University of Johannesburg find that shining a near-infrared laser on adult stem cells derived from human body fat, makes the stem cells replicate 54% faster.

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