Keyword: stem cells

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Myelodysplastic syndrome

Genetic testing helps predict disease recurrence

A DNA-based analysis of blood cells soon after a stem cell transplant can predict likelihood of disease recurrence in patients with myelodysplastic syndrome (MDS), a group of cancerous disorders characterized by dysfunctional blood cells. Such a practice could help doctors identify patients at high risk of disease recurrence early after a transplant and help guide treatment decisions.

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bioengineering

Advancing technique for of personalied bone grafts

Scientists have developed a new bone engineering technique called Segmental Additive Tissue Engineering (SATE). The technique allows researchers to combine segments of bone engineered from stem cells to create large scale, personalized grafts that will enhance treatment for those suffering from bone disease or injury through regenerative medicine.

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Hematopoietic Stem Cells

What keeps our blood in balance

Blood is the juice of life, as while circulating through the body it delivers vital substances such as oxygen and nutrients to cells and tissues. Chemotherapy, radiotherapy and blood loss in general impoverish the system. A special kind of cells in the bone marrow, called hematopoietic stem cells (HSCs) is able to replenish the impoverished system by giving rise not only to red blood cells, but…

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Research support

Stem cell therapy for traumatic injury on the horizon

The University of Texas Health Science Center at Houston (UTHealth) has received funding through a public/private partnership for the first-ever clinical trial investigating a stem cell therapy for early treatment and prevention of complications after severe traumatic injury. The proposed Phase 2 trial is underwritten with $2 million from the Medical Technology Consortium (MTEC) and $1.5 million…

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Hypoplastic left heart syndrome (HLHS)

Stem cells might be the key to treating rare cardiac defect

Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart. The Phase I study is part of a multi-center collaboration dedicated to employing innovative therapies to improve outcomes for children…

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Efferocytosis

Can stem cell exosome therapy reduce fatal heart disease in diabetes?

Macrophage cells routinely remove dead or dying cells to maintain the body homeostasis. Such removal becomes crucial after serious injury, especially the repair of dead heart muscle after a heart attack. University of Alabama at Birmingham researchers have preliminary data, with cultured cells or diabetic hearts, that diabetes impairs this removal of dead heart-muscle cells. They believe this…

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Neurogenesis

These genetic ‘switches’ determine our brain development

UCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life. The human brain differs from that of mice and…

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Milestone

Researcher grow hairy skin in a dish

Researchers at Indiana University School of Medicine have successfully developed a method to grow hairy skin from mouse pluripotent stem cells - a discovery that could lead to new approaches to model disease and new therapies for the treatment of skin disorders and cancers.

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Duchenne

Researchers create skeletal muscle from stem cells

Scientists from the University of California, Los Angeles (UCLA) have developed a new strategy to efficiently isolate, mature and transplant skeletal muscle cells created from human pluripotent stem cells, which can produce all cell types of the body. The findings are a major step towards developing a stem cell replacement therapy for muscle diseases including Duchenne Muscular Dystrophy, which…

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Deafness reversal

Inner ear stem cells may someday restore hearing

Want to restore hearing by injecting stem cells into the inner ear? Well, that can be a double-edged sword. Inner ear stem cells can be converted to auditory neurons that could reverse deafness, but the process can also make those cells divide too quickly, posing a cancer risk, according to a study led by Rutgers University–New Brunswick scientists. The encouraging news is that turning stem…

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Time-lapse microscopy

Image correction software simplifies quantification of stem cells

Today, tracking the development of individual cells and spotting the associated factors under the microscope is nothing unusual. However, impairments like shadows or changes in the background complicate the interpretation of data. Now, researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München have developed a software that corrects images to make hitherto hidden…

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Cancer development

Tumor induction from a distance

Current view is that cancer development is initiated from cells that acquire initial DNA mutations. These in turn provoke additional defects, and ultimately the affected cells begin to proliferate in an uncontrolled manner to develop primary tumors. These can later spread and create metastases, or secondary tumors, in other parts of the body. However, according to a study by researchers at the…

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Global database

Scientists create leukaemia online tool to aid search for cure

Finding a cure for a rare type of blood cancer could be accelerated by a new virtual platform that allows researchers easy access to data from patient samples generated by laboratories around the world. LEUKomics, which has been launched by scientists at the University of Glasgow and the University of Melbourne, is a comprehensive database describing over 100 chronic myeloid leukaemia (CML)…

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Stem cell research

3D bioprinting of cartilage could soon be a reality

A team of researchers at Sahlgrenska Academy has managed to generate cartilage tissue by printing stem cells using a 3D-bioprinter. The fact that the stem cells survived being printed in this manner is a success in itself. In addition, the research team was able to influence the cells to multiply and differentiate to form chondrocytes (cartilage cells) in the printed structure.

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Biotechnology

Engineered muscle for the treatment of heart failure

MBM ScienceBridge GmbH successfully negotiated a license agreement between Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin (UMG) and the biotech company Repairon GmbH about commercial production and use of engineered human myocardium for heart failure repair. The production methods are based on the scientific work from the group of Prof. Dr.…

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Deep Learning

Deep Learning predicts hematopoietic stem cell development

Autonomous driving, automatic speech recognition, and the game Go: Deep Learning is generating more and more public awareness. Scientists at the Helmholtz Zentrum München and their partners at ETH Zurich and the Technical University of Munich (TUM) have now used it to determine the development of hematopoietic stem cells in advance. In ‘Nature Methods’ they describe how their software…

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Scientists tissue-engineer part of human stomach

Researchers at Cincinnati Children’s Hospital Medical Center grew functional stomach and intestinal tissues to study diseases and new drugs. They use pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes.

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For tissue engineering

Technique generates human neural stem cells

Tufts University researchers have discovered a new technique for generating rapidly-differentiating human neural stem cells for use in a variety of tissue engineering applications, including a three-dimensional model of the human brain, according to a paper published in Stem Cell Reports. The work could pave the way for experiments that engineer other innervated tissues, such as the skin and…

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Fight inflammation

Stem cells engineered to grow cartilage

With a goal of treating worn, arthritic hips without extensive surgery to replace them, scientists have programmed stem cells to grow new cartilage on a 3-D template shaped like the ball of a hip joint. What’s more, using gene therapy, they have activated the new cartilage to release anti-inflammatory molecules to fend off a return of arthritis. The technique was demonstrated in a collaborative…

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Dividing T cells

Target for improving cancer immunotherapy

When an immune T cell divides into two daughter cells, the activity of an enzyme called mTORC1, which controls protein production, splits unevenly between the progeny, producing two cells with different properties. Such "asymmetric division," uncovered by Johns Hopkins Kimmel Cancer Center researchers using lab-grown cells and specially bred mice, could offer new ways to enhance cancer…

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