More than 80 billion neurons, trillions of synapses and almost 6 kilometres of neural pathways: The brain is an anatomical masterpiece; it is our control centre, memory store, coordinator of thoughts and movement – and still puzzles science. In medicine, the focus is on neurodegenerative diseases such as Alzheimer's and Parkinson's, but also on cerebrovascular disorders such as strokes and brain tumours, notably glioblastoma.
A promising technology enables deep brain stimulation without the need to surgically implant electrodes. This could pave the way for its use in the treatment of neurological and psychiatric disorders.
At which point does Alzheimer’s disease pathology lead to dementia? Researchers identified distinct mechanisms in the brain, which could represent an important target for future therapies.
A new PET imaging approach that measures synaptic density in the spinal cord provides a quantitative way to assess the brain's functional wiring in patients with multiple sclerosis.
A new AI-based method can reduce the time required for certain MRI brain scans by up to 90% while maintaining a high level of accuracy, paving the way for more efficient and accessible neuroimaging.
Persistent long Covid symptoms are often linked to brain inflammation. However, results from a new study point at a different explanantion for fatigue, cognitive impairment, anxiety, and depression.
New research has found that a genetic factor best known for increasing the risk of Alzheimer's disease, may also influence how pathological changes spread in amyotrophic lateral sclerosis (ALS).
New research reveals that testosterone slows glioblastoma growth—the opposite of the androgen’s effect on tumors outside the brain.
Researchers at the Leibniz Institute on Aging have shown that oxidative stress impairs protein quality control in the brain – and that this process is reversible.
Researchers are developing nanozymes to improve treatment of aggressive brain tumours. The tiny particles can be activated by near-infrared light and applied directly during surgery.
Why do some older adults remain mentally sharp despite having Alzheimer's? Decoding this natural resilience could pave the way for earlier detection and new strategies to prevent memory loss.
A 3D brain marker may help identify which patients with idiopathic normal pressure hydrocephalus (iNPH) benefit from shunt surgery – improving outcomes and sparing others from ineffective treatment.
Repeated menstrual cycles may do more than trigger endometriosis – they may rewire the brain, a new study finds. Recurring inflammation can sensitize the nervous system, driving lasting pain.
Neural implants show great potential, but the brain's reaction to foreign objects remains a challenge. New research insights could now pave the way for more biocompatible brain implants.
Why does the same genetic mutation cause FCDII in some patients but not in others? Researchers developed organoids to model a brain malformation responsible for drug-resistant epilepsy in children.
Researchers have developed a new MRI-based method that enables objective quantification of the growth of the most aggressive brain tumours, particularly glioblastoma.
Researchers have developed an AI model showing that it is possible to detect different neurodegenerative diseases - for example, Alzheimer’s and Lewy body disease - from a single blood sample.
Patient-derived organoids (PDOs), or tumoroids, for pediatric brain cancer show promise in helping researchers find new drugs and better understand the different responses of the tumor.
New treatments for neurodegenerative diseases like Alzheimer’s, Parkinson’s, and motor neurone disease (MND) could be unlocked thanks to microscopic medicines called intrabodies.
Severe infections could increase the risk of developing dementia years later, independently of other coexisting illnesses, a new study from Finland suggests.
