Keyword: antibiotic resistance

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MRSA & Co.

Test to detect antibiotic resistance in less than 45 minutes

Scientists from Scotland are developing a low cost, rapid diagnostic sensor test which aims to show the susceptibility of bacteria to antibiotics within 45 minutes. Laboratory testing of samples can take up to two days and the new test aims to allow doctors to be able to prescribe the correct antibiotic to a patient for an infection more quickly. In a research paper published in the journal…

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Fighting resistant bacteria

Novel class of antibiotics brings new options

Many life-threatening bacteria are becoming increasingly resistant to existing antibiotics. Swiss researchers co-headed by the University of Zurich have now discovered a new class of antibiotics with a unique spectrum of activity and mechanism of action. By disrupting outer membrane synthesis, the antibiotics effectively kill Gram-negative bacteria. According to the World Health Organization…

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Natural nanocapsules

A new approach for tackling superbugs – without antibiotics

Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients. Helicobacter pylori is a bacterial pathogen carried by 4.4 billion people worldwide, with the highest prevalence in Africa, Latin America and the Caribbean. Although the majority of infections show no symptoms,…

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ClpX-ClpP protein complex

Weak spot in pathogens could be key in new antibiotics

Antibiotics are still the most important weapon for combatting bacterial infections. But medical science is running out of “ammunition” because of more and more frequently occurring resistances. A research team has now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to development of innovative antibiotics which target the degradation process of defective proteins…

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Microbiology

Resistance can spread without antibiotics use

Bacteria are becoming increasingly resistant to common antibiotics. Often, resistance is mediated by resistance genes, which can simply jump from one bacterial population to the next. It’s a common assumption that the resistance genes spread primarily when antibiotics are used, a rationale backed up by Darwin's theory: only in cases where antibiotics are actually being used does a resistant…

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Pathogenic microbes

Cigarette smoke makes MRSA superbug bacterium more drug-resistant

Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of Staphylococcus aureus – a microbe present in 30-60% of the global population and responsible for many diseases, some fatal – more invasive and persistent, although the effect is not universal across all…

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XDR Klebsiella pneumoniae

Antibiotic resistance in Europe: Hospitals are part of the problem

New research has found that antibiotic-resistant strains of Klebsiella pneumoniae, an opportunistic pathogen that can cause respiratory and bloodstream infections in humans, are spreading through hospitals in Europe. Certain strains of K. pneumoniae are resistant to the carbapenem antibiotics that represent the last line of defence in treating infections and are therefore regarded as extremely…

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Not just the climate changes

Global warming might be behind the rise of Candida auris

Global warming may have played a pivotal role in the emergence of Candida auris. According to a new study published in mBio, an open-access journal of the American Society for Microbiology, C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change. “The argument that we are making based on…

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Microbiology & hygiene

HAIs are one problem – MDROs another

In view of the increase of multidrug-resistant organisms (MDRO), the World Health Organisation (WHO) has declared antibiotic resistance one of the biggest threats to global health. MDROs have become a major problem particularly in hospitals. Professor Dr Georg Häcker, President of the German Society of Hygiene and Microbiology (DGHM) and Director of the Institute for Microbiology and Hygiene at…

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Rapid, reliable microbe identification

The Bologna Workflow System

Many countries across the world are challenged with a rising number of incidences of multi-drug resistant (MDR) organisms infecting the population, and for several years, a clear pattern of increased resistance has emerged in southern and eastern European countries. For example, in countries such as Italy, a reduced number of therapeutic options remain available for highly pathogenic infections,…

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Infection control

Global opportunity to tackle antibiotic production waste

As leaders gather for the International Ministerial Conference on antimicrobial resistance (AMR), hosted by the government of The Netherlands and organised in close cooperation with the FAO, OIE and WHO, experts and responsible manufacturers are calling for a 'One Health' approach to AMR and recognition of the impact of antibiotic production on the environment. "With two thirds of the worlds…

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Product launch

New instrument for automated antimicrobial susceptibility testing

A new benchtop automated reading and incubation system is now available in Europe for antimicrobial susceptibility testing (AST). The new instrument provides microbiology laboratories with the accurate MIC results that clinicians need to confidently select an effective antibiotic for critically-ill patients while safeguarding future patient care through more successful antimicrobial stewardship.…

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Survival specialists

Systems biology of antibiotics

Bacteria have fascinating properties. They adapt excellently to their respective environment, and they existed long before humans. Their toughness has led to the fact that bacteria have successfully spread all over the world for three billion years – even in places where humans could not survive, for example in the hottest springs and in the coldest places on earth. However, they were only…

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Fake pills

'Decoy' antibiotics dupe bacteria’s defences

Imperial medical students have helped to devise a new type of ‘decoy’ drug to tackle infections that are resistant to antibiotics. In lab tests on bacterial cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden. When the bacteria fight against the first ‘decoy’ antibiotic, this action…

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Epidemiology & economics

Bacterial resistance costs French hospitals up to 290 million Euros per year

A team of researchers from Versailles Saint-Quentin-en-Yvelines University (UVSQ), Inserm and Pasteur Institute (Unité Mixte de Recherche 1181 Biostatistique, biomathématique, pharmacoépidémiologie et maladies infectieuses – B2PHI) has been able to provide for the first time an accurate estimate of both the incidence (annual number of new cases) and added direct cost of infections due to…

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Survival of the fittest

How bacteria can adapt to resist antibiotic treatment

In a joint collaboration, researchers from Denmark and Switzerland have shown that bacteria produce a specific stress molecule, divide more slowly, and thus save energy when they are exposed to antibiotics. The new knowledge is expected to form the basis for development of a new type of antibiotics. All free-living organisms are under constant pressure to survive. Darwin dubbed this…

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A new weapon against antibiotic resistance

Programming a hunter/killer toxin

When the first antibiotics were discovered in the early 20th century, the rate of death from infectious diseases fell dramatically. But the emergence of multidrug-resistant bacteria as a result of antibiotic misuse is raising fears that by 2050, these same diseases will once again become the leading cause of death worldwide. In a bid to boost the arsenal available to tackle this threat,…

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Nosocomial infections

Global-PPS: Hospital antibiotic resistance study tops 200k

BioMérieux and the Laboratory of Medical Microbiology at the University of Antwerp announced at ECCMID (European Congress of Clinical Microbiology & Infectious Diseases) the 2018 results of the Global Point Prevalence Survey (GLOBAL-PPS), a study of antibiotic use and antimicrobial resistance (AMR) in hospitals around the world. Since its launch in 2015, this survey has been conducted in…

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Differentiate and select

Myths and truths about antibiotics, antiseptics and vaccination

Sixty-two percent of Germans fear antibiotic resistance, according to a survey recently conducted by the German Federal Institute for Risk Assessment. ‘Patients colonised by multi-resistant pathogens are particularly scared. But many of these fears are rooted in misunderstandings,’ explained Professor Mathias Pletz, Director of the Institute of Infection Medicine and Hospital Hygiene at…

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Antimicrobial resistance

Apocalypse postponed: upcoming antibiotics bring hope

Antimicrobial resistance is a global issue, with 700,000 deaths per year and 10 million expected deaths by 2050, according to predictions. Appropriate antimicrobial therapy can help to save lives, and a long awaited cure for carbapenemase-producing enterobacteriaceae (CPE) will soon be released, according to eminent Spanish expert Jose Mensa Pueyo, speaking at a Madrid meeting in March. The past…

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Infection control

Knowledge is one thing - implementation another

Insufficient knowledge of infection control, resulting in insufficient compliance, increases the risk of hospital acquired infections (HAIs) and multiresistant pathogens that put patients at risk. At the 2019 Annual General Meeting of the German Society for Hygiene and Microbiology e.V. (DGHM) in Göttingen, Professor Frauke Mattner, Senior Consultant at the Institute of Hygiene, Kliniken der…

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Symposium @ ECCMID 2019

How laboratories can help detect AMR and sepsis sooner

Beckman Coulter, a global leader in clinical diagnostics will be demonstrating its latest comprehensive solutions in microbiology, urinalysis and hematology at the 29th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). During the conference, Beckman Coulter is also hosting a symposium where attendees will learn how the laboratory can help physicians detect…

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