A Cambridge study reveals how tumours suppress immune responses – and how blocking this mechanism could make immunotherapies effective in more patients.
Radiotherapy may be able to do far more than simply destroy tumor cells. A review explores how combining radiotherapy with immunotherapy could improve outcomes for patients with pancreatic cancer.
Researchers have found an ‘immune organ’ inside the skull, which directs brain defenses. The findings may offer a new way to fight brain cancer and neurodegenerative diseases.
In the DISCOVER-ME project, researchers search for biological characteristics of myalgic encephalomyelitis, and also investigate whether patients can be divided into different subgroups.
A novel study shows that exposure to air pollution, especially fine particulate matter (PM2.5), is associated with increased disease activity and flare risk in rheumatoid arthritis (RA).
The characteristic white skin patches of vitiligo are caused by a lack of skin pigments – or so we thought. New research suggests that melanocytes merely enter a dormant state – from which they may be awakened.
Tumour-infiltrating lymphocytes are key players in cancer immunotherapy. New research explores the role of location in the tumour microenvironment – knowledge that could help improve treatments.
Breastfeeding is recognized for its role in supporting a child's growth and immune system development. However, new research paints a more nuanced picture on its effect on childhood allergy.
Virus-associated molecules in the foot are enough to trigger the network: Research reveals a remarkable mechanism, in which the brain prepares for a potential viral attack within hours of infection.
A pilot study shows that immunotherapy may enable stimulation of egg maturation in women with premature menopause. Three out of ten women gave birth to healthy babies following the treatment.
A study from the University of Calgary shows that removing a single gene makes colon cancer cells a target for immunotherapy — a fundamental breakthrough.
A Taiwanese research team found that BET inhibitors can restore exhausted T cells by reprogramming their metabolism – a potential new strategy for cancer immunotherapy.
Prof. Johanna Joyce has begun her two-year term as President of the European Association for Cancer Research (EACR), a global community of scientists and clinicians dedicated to advancing the scientific understanding of cancer and its application to improve patient care.
Many women with myasthenia gravis choose not to have children due to fear that the disease will get worse during or after pregnancy. Now, a study investigated the connection to the autoimmune disease.
Researchers have reported results from a first-in-human trial evaluating a novel cell-based platform for localized delivery of interleukin-2 (IL-2) in patients with advanced ovarian cancer.
Researchers have used cryo-expansion microscopy to capture cytotoxic T lymphocytes destroying cancer cells in unprecedented 3D detail, opening new paths in immuno-oncology.
Neural implants show great potential, but the brain's reaction to foreign objects remains a challenge. New research insights could now pave the way for more biocompatible brain implants.
A new technique to “prime” a patient's immune system before liver transplantation has proven itself in a first-in-human clinical trial to successfully prevent transplant rejection.
Being overweight can reduce vaccine effectiveness, new research finds. The findings explore differences in immune response, and may lead to more effective vaccines for patients with obesity.
