Immune system

News • Virtual, dynamic model

"Immune Digital Twins" to tackle autoimmune disorders, infectious diseases

An international project to create a ‘digital twin’ of the human immune system could help scientists finally tackle grand challenges such as autoimmune disorders and infectious diseases.

News • Peripheral immune tolerance

Immune system researchers receive Nobel Prize 2025 in Medicine

The 2025 Nobel Prize in Physiology or Medicine is awarded to three researchers for their insights into peripheral immune tolerance - how our immune system is kept from attacking our own body.

News • AML targetable immune escape mechanism

How leukemia cells trick the immune system

Immunotherapy has improved the treatment for many cancers, but progress has been limited in leukemia. Discovery of a new evasive mechanism could help change that.

News • Public health

What is ‘herd immunity’ and how can it help eliminate infectious diseases?

When the many protect the few: An expert explains the premise of herd immunity, and how vaccinations apply the priciple in preventing communicable diseases, notably in the complete eradication of…

News • Study shows widespread disruption

Glioblastoma: damage beyond the brain

Scientists have shown for the first time that glioblastoma—the deadliest form of brain cancer—affects not just the brain but also erodes the skull, alters the makeup of skull marrow, and…

News • Neural anticipation of infection

Virtual health threats trigger real immune response

The mere fact of being exposed to a sick avatar in a virtual reality environment triggers a measurable immune response in humans, a multidisciplinary research team discovered.

News • Predictive phenotypes

Ovarian cancer: new insights into immune landscapes

Defining four different immunologic subtypes of recurrent ovarian cancers, researchers pave the way for more personalized treatment.

News • Device biocompatibility research

Improving the body's tolerance to prosthetic implants

Coating an electronic neural implant with a potent anti-inflammatory drug helps the body better tolerate the implant, improving its long-term performance and stability, according to new research.

News • Auto-immune condition

Lupus: study explores causes and impact of diagnostic delays

Patients with systemic lupus erythematosus (SLE or ‘lupus’) may wait for up to 40 years to receive the correct diagnosis. New research highlights the causes and devastating impact of these delays.

News • Research into immunocompetence

Early infection defense mechanism discovered in embryos

New research shows how embryos can protect themselves from bacterial infections even before forming their immune system. The findings could provide new insights into the origin of immunity.

News • Genetic signature mapping

Diagnosing Parkinson’s from a blood sample

In a world first, researchers have identified a set of biomarkers that could someday make it easy to spot Parkinson's disease in a patient’s blood sample.

News • Stratification of TSCC immunotypes

Tongue cancer: Immune profiling for improved outcomes

Tongue squamous cell carcinoma, the most common type of oral cancer, is a challenging target for immunotherapies. Researchers now identified five immunotypes to better predict treatment response.

News • Early detection of life-threatening conditions

Newborn immune profiling to improve neonatal care

Newborns, especially those born prematurely, are vulnerable to conditions such as sepsis. A new device profiles an infant’s immune function from a single drop of blood to improve neonatal care.

News • From neutrophil to PMN-MDSC

Blood cell corruption identified as path to severe Covid

A US research team has shown that Sars-CoV-2 can “reprogram” pathogen-fighting white blood cells into immune system suppressing cells — a potential mechanism by which severe Covid may arise.

News • Bioengineered scaffolds

New hydrogel to improve CAR T immunotherapy

Researchers developed biomimetic materials inspired by lymph nodes, which could improve cancer immunotherapy. The study highlights the potential of bioengineered scaffolds for cell-based therapies.

News • Systemic cell rewiring

How midkine helps tumours evade immunotherapy

Researchers discovered a key mechanism by which melanomas and other aggressive tumours prevent the immune system from detecting and attacking them – one of the greatest challenges in oncology today.

News • Study explores effects on immune system

Night shift nurses may pay for their sleep debt with infections

A new study examining the effects of sleep patterns and shift work on the immune system has found that sleep debt and night shifts increase the risk of several common infections in nurses.

News • A closer look at the GI microbiome

“Gut-on-a-chip” predicts immunotherapy efficacy against melanoma

The gastrointestinal microbiome holds valuable information that can help predict whether immunotherapy will be successful against melanoma. A new “gut-on-a-chip” is designed to do exactly that.

News • Potentiator of AMR emergence and expansion

Diabetes as a driver of antibiotic resistance

Microbiologists have just shown that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, a leading cause of AMR-associated infections and deaths.

News • Alteration of immune response

Multiple myeloma: dangerous diversity

When multiple myeloma cancer cells break out and multiply outside the bone marrow, a wide variety of tumor cells arise, accompanied by a significantly altered immune response, new research shows.

News • Potential for new cardiac treatments

Born to heal: Why babies recover after heart damage, but adults do not

Newborns with heart complications can rely on their immune systems to regenerate, but adults aren’t so lucky. A new study explores this mechanism, paving the way for treatments after a heart attack.

News • Micro Immune Response On chip (MIRO)

Replicating tumours to assess cancer immunotherapy efficacy

Researchers have developed a new kind of tumour-on-a-chip, which gives insight into the tumour environment and immunotherapy response. The device has been successfully tested on breast cancer samples.

News • Researcher reveals vulnerability

New approach to crack persister tumour cells

Persister cells arise as a result of cancer treatment and are often responsible for tumour relapse. Researchers identified a distinctive feature of persister cells, paving the way for new treatments.

News • Immuno-monitoring study

New ways for childhood cancer immunotherapies

The immune system of children reacts differently to cancer than that of adults. New insights into these differences have the potential to lead to new tailored treatments for children with cancer.

News • Patient-derived samples

New ‘explant’ technique predicts breast cancer therapy response

A new study measured how well breast cancer patients’ tumour ‘explants’ respond to chemotherapy or HER2 antibody therapy in the laboratory. This could help improve clinical outcomes.

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