Ever since the Abbe diffraction limit of conventional microscopy has been surpassed, super-resolution techniques have been diving ever deeper into the most miniscule details of molecular structures. We spoke with Prof. Dominic Zerulla, whose company PEARlabs is developing an imaging technique that sets out to push the boundaries once more – by looking at in-vivo nano-scale processes in motion.
Researchers at the McKelvey School of Engineering at Washington University in St. Louis found a way to significantly reduce the noise and maintain image quality while reducing the laser energy needed to generate images by 80%.
A 'new technology shows promise by analyzing images of suspicious-looking lesions and quickly producing a detailed, microscopic image of the skin, bypassing several standard steps typically used for diagnosis - including skin biopsy, tissue fixation, processing, sectioning and histochemical staining.
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
If the suspicion of Alzheimer's disease creeps up, those affected must prepare themselves for lengthy and complex procedures until the case is clear. A team from Empa and the Cantonal Hospital of St. Gallen is now in the process of developing a blood test that will enable a reliable diagnosis using atomic force microscopy (AFM).
Researchers at Umeå University now demonstrate a method by which specific cell types in human organs can be studied with micrometer precision. The method can be used to reveal previously unrecognised alterations in the pancreas, but it can also be used to study other human organs and diseases.
Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.
Researchers from ETH Zurich and University of Zurich have developed a new microscopy technique that lights up the brain with high resolution imagery. This allows neuroscientists to study brain functions and ailments more closely and non-invasively.
University of Birmingham scientists have developed a new microscopic imaging approach to take a closer look at 3D-printing for developing future patient implants, as well as improved disease modelling and drug screening. Additive manufacturing (3D printing) platforms create bioprinted structures by moving a special bioink, containing cells, biomolecules and materials, through a narrow tube, but…
Did you know that changing microscopy camera can make a real difference to your microscopy workflow? Packed full of smart features to make your imaging faster and easier, Olympus’ new DP23 and DP28 (4K) cameras enable streamlined, comfortable sample analyses at the monitor and easier, smoother conferencing. Get the most out of the monitor view and discover the many benefits of the DP23 and DP28…
Using an ordinary light microscope, engineers at the Massachusetts Institute of Technology (MIT) have devised a technique for imaging biological samples with accuracy at the scale of 10 nanometers — which should enable them to image viruses and potentially even single biomolecules, the researchers say. The new technique builds on expansion microscopy, an approach that involves embedding…
An improved high-tech fluorescence microscopy technique is allowing researchers to film cells inside the breast as never seen before. This new protocol provides detailed instructions on how to capture hi-res movies of cell movement, division and cooperation, in hard-to-reach regions of breast tissue. The technology – called multiphoton microscopy – uses infrared lasers to illuminate…
Researchers at the Universitat Autònoma de Barcelona obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies.
Researchers at the University of Arizona are developing a Covid-19 testing method that uses a smartphone microscope to analyze saliva samples and deliver results in about 10 minutes. The research team, led by biomedical engineering professor Jeong-Yeol Yoon, aims to combine the speed of existing nasal swab antigen tests with the high accuracy of nasal swab PCR, or polymerase chain reaction,…
Improving the detection of cancerous cells during surgery – this is the goal of the European research project CARMEN. The research institutes Laser Zentrum Hannover e.V. (LZH) from Germany and Multitel asbl from Belgium work together with companies from both countries, JenLab GmbH, Deltatec, and LaserSpec, to develop a novel, compact and multimodal imaging system. This could even allow the…
For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes.
In a new study, researchers performed a detailed imaging analysis to determine how the virus reprograms infected cells.
In order to analyze tumors, they have to be cut into thin slices. Now, a new technology has been developed that makes pieces of the tumor visible in 3D without cutting them.
Scientists have developed a tool that improves the resolution and accuracy of powerful microscopes that are used to reveal insights into biology and medicine. In a study published in Nature Methods, a multi-institutional team led by Tom Terwilliger from the New Mexico Consortium and including researchers from Lawrence Berkeley National Laboratory (Berkeley Lab) demonstrates how a new computer…
