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Liver

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News • Alternative to liver biopsy

Exploring the benefits of non-invasive MR Elastography in obese patients

Omar Darwish, PhD student at King's College London, is researching new approaches to 3D MRE sequences for measuring liver fibrosis and inflammation simultaneously in obese patients.

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News • OrQA

Transplant organ quality assessment via AI: a promising approach

A pioneering new method to assess the quality of organs for donation has the potential to revolutionise the transplant system, saving lives and tens of millions of pounds.

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News • Preventing EBV reactivation

Liver transplantation: Finding the "sweet spot" of immuno-suppression

Dutch physicians have developed a system to determine the right dose of immunosuppressive drugs for patients to receive a donor liver - to prevent the activation of the Epstein-Barr virus.

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Article • Imaging advances

Liver disease assessment: AI may give CT the edge over MRI

To assess diffuse liver disease, MRI is currently the modality of choice. New developments in artificial intelligence (AI) could tip the scales in favour of CT imaging. At ECR 2022 in July, experts…

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News • Tumour shrinking

"Downstaging" liver cancer before transplant improves outcomes

Treating liver cancer tumours to shrink them in order to allow the patient to qualify for a liver transplant leads to excellent 10-year post-transplant outcomes, according to new research.

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News • HCC in vitro research

Organoids give new clues to liver cancer progression

Newly engineered in vitro tumour models open ways to better understand the crosstalk between liver cancer cells and their microenvironment, researchers from Singapore found.

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Sponsored • Chronic liver disease

A looming pandemic and the need for physician partnerships to leverage non-invasive testing

Even as we battle one pandemic (Covid-19), we sit on the cusp of another. Europe has one of the highest burdens of chronic liver disease (CLD) in the world, driven largely by alcohol overconsumption, viral hepatitis, and obesity. Furthermore, non-alcoholic fatty liver disease (NAFLD) is increasingly common and is a significant contributor to CLD – especially in people with diabetes, where its…

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Article • An estimated 800,000 deaths in 2030

Warning of looming global liver disease pandemic

Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.

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News • Rare liver disease

New test improves diagnosis of autoimmune hepatitis

Autoimmune hepatitis (AIH) is a chronic liver inflammation that is triggered by an immunological malfunction. In this case, the immune system falsely recognises the patient's own liver cells as "foreign to the body". The symptoms of this rare liver disease are unspecific, and the exact cause is not yet known. If left untreated, AIH can lead to abnormal scarring (fibrosis) of the liver,…

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News • Nephrolith research

Fatty liver disease promotes formation of kidney stones

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in western countries, with an increasing incidence worldwide. Consequences of NAFLD can also include kidney disease and kidney stones, although the mechanisms for the development of these kidney complications as a result of NAFLD have not yet been fully explained. Researchers at the Leibniz Research Centre for Working…

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News • NAFLD research

3D imaging reveals neural ‘vicious cycle’ in fatty liver disease

With the application of a novel 3D imaging technology, researchers at Karolinska Institutet have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is conducted in mice and human liver tissue, shows that the degeneration of nerves is correlated with the severity of liver pathology. The…

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News • Donor organ analysis

New laser technique could improve liver transplant process

Handheld laser devices that help surgeons quickly spot liver damage could transform transplant procedures, research suggests. The non-invasive technique could provide medical staff with instant data on the health of donor livers and help them to identify which organs are suitable for transplant. If widely adopted, the light-based tool could allow more livers to be transplanted safely and…

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News • Outcome prediction

Deep learning to maximize lifespan after liver transplant

Researchers from the Canadian University Healh Network (UHN) have developed and validated a deep learning model to predict a patient's long-term outcome after receiving a liver transplant. First of its kind in the field of Transplantation, this model is the result of a collaboration between the Ajmera Transplant Centre and Peter Munk Cardiac Centre (PMCC). The study, published in Lancet Digital…

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News • Bioengineering

Producing transplantable livers in the laboratory

Researchers at the Human Genome and Stem Cell Research Center (HUG-CELL), hosted by the University of São Paulo’s Institute of Biosciences (IB-USP) in Brazil, have developed a technique to reconstruct and produce livers in the laboratory. The proof-of-concept study was conducted with rat livers. In the next stage of their research, the scientists will adapt the technique for the production of…

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News • The hidden 'fingerprint' of liver cirrhosis

Routine blood tests could be key to stopping 'silent killer'

New research has shown that results of blood tests routinely performed by GPs everywhere contain a hidden fingerprint that can identify people silently developing potentially fatal liver cirrhosis. The researchers have developed an algorithm to detect this fingerprint that could be freely installed on any clinical computer, making this a low-cost way for GPs to carry out large scale screening…

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Article • At ECR 2021

AI experts tackle organ segmentation and health economics

AI is revamping workflows and experts showed how radiologists can integrate it into their department to improve daily practice and healthcare at ECR. The panel also discussed the health economics side of AI to help radiologists define which products make more economic sense for their department. The session tackled automated organ segmentation, an interesting application for AI in radiology.

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Video • Regenerative medicine

Lab-grown ‘mini-bile ducts’ to repair human livers

Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. The research paves the way for cell therapies to treat liver disease – in other words, growing ‘mini-bile ducts’ in the lab as…

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Video • For breakthroughs against Hepatitis C

Nobel Prize in Medicine goes to Harvey J. Alter, Michael Houghton and Charles M. Rice

The 2020 Nobel Prize in Medicine is awarded to three scientists who have made a decisive contribution to the fight against blood-borne hepatitis, a major global health problem that causes cirrhosis and liver cancer in people around the world. Harvey J. Alter, Michael Houghton and Charles M. Rice made seminal discoveries that led to the identification of a novel virus, Hepatitis C virus.

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News • Infrared imaging

New imaging method to detect and monitor liver disease

It’s currently difficult to screen for certain liver diseases and to monitor these conditions once they’re discovered. A team led by investigators at Massachusetts General Hospital (MGH) and the Massachusetts Institute of Technology (MIT) recently developed a non-invasive imaging method that has promising clinical potential to accomplish both goals. The technique is described in a study…

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