Keyword: medication

Photo

Experimental drug

Fighting Hepatitis B with 'virus-cracking' molecules

Indiana University researchers have made an important step forward in the design of drugs that fight the hepatitis B virus, which can cause liver failure and liver cancer. It's estimated that 2 billion people worldwide have had a hepatitis B virus infection in their lifetime, with about 250 million -- including 2 million Americans -- living with chronic infection. Although a vaccine exists, there…

Photo

Drug manufacturing

3D printing pharmaceuticals with this chemical ‘MP3 player’

A new method of drug manufacture which uses 3D printers to create pharmaceuticals on demand could lead to a ‘Spotify for chemistry’, scientists claim. In a new paper published in the journal Science, researchers from the University of Glasgow present for the first time a new approach to the manufacture of pharmaceuticals which can be made using a digital code. This code is used by a 3D…

Photo

Experimental medicine

Loophole in chronic lymphocytic leukemia treatment detected

A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of patients. The study, published in the Journal of Experimental Medicine, reveals that ibrutinib has a diminished capacity to delocalize and kill tumor cells expressing an adhesive protein called CD49d, but combining ibrutinib…

Photo

Effectiveness study

Medications alone don’t help smokers quit

Pharmaceutical interventions are routinely prescribed to help people quit smoking. However, a new study by University of California San Diego School of Medicine researchers suggests that, despite promising results in clinical trials, smoking cessation drugs alone may not be improving the chances of successful quitting among smokers in general.

Photo

Research

Experimental drug interferes with Alzheimer’s mechanisms

The chemical compound “anle138b” eases cognitive deficits and normalizes gene expression in a mouse model of Alzheimer’s disease. Furthermore, the drug seems to close harmful openings in the membrane of nerve cells. An international collaboration reports these findings in the journal “EMBO Molecular Medicine”. The scientists suggest that anle138b should be validated in clinical trials…

Photo

More than the sum of its parts?

Combination strategy could hold promise for ovarian cancer

Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone. The study already spurred a clinical trial in ovarian cancer patients. The…

Photo

New study reveals

Treatment window for strokes might be larger than previously thought

Treating stroke has long been governed by the clock. If it has been less than three hours since the onset of symptoms, the clot-busting drug t-PA will likely work. If it has been four and a half hours, some selected patients might benefit. However, if it has been more than six hours, treatment options have been few. Now that conventional wisdom has been turned on its head. The final results of…

Photo

Lung infections

Four simple tests to help spot pneumonia and reduce unnecessary antibiotics

Testing for fever, high pulse rate, crackly breath sounds, and low oxygen levels could be key to helping GPs distinguish pneumonia from less serious infections, according to a large study published in the European Respiratory Journal. Pneumonia is a severe lung infection that can be life-threatening and often requires treatment with antibiotics. However, it is notoriously difficult to…

Photo

Golden helpers

Nanoparticles could allow for faster, better medicine

Gold nanoparticles could help make drugs act more quickly and effectively, according to new research conducted at Binghamton University, State University of New York. Nanoparticles are microscopic particles that are bigger than atoms but smaller than what the eye can see. They are unique for their large surface area-to-volume ratio and their fairly ubiquitous nature. A new study, co-conducted by…

Photo

Staying alert

Breast cancer recurrence risk lingers years after treatment ends

Even 20 years after a diagnosis, women with a type of breast cancer fueled by estrogen still face a substantial risk of cancer returning or spreading, according to a new analysis from an international team of investigators published in the New England Journal of Medicine. Standard treatment for estrogen receptor-positive, or ER-positive, breast cancer includes five years of the endocrine-based…

Photo

Sertraline usage

Standard antidepressant may be ineffective with chronic kidney disease patients

A clinical trial involving hundreds of participants has shown that one of the most frequently prescribed antidepressants may not benefit millions of patients who also have chronic kidney disease (CKD). “These results provide evidence that could change clinical practice,” said Dr. Susan Hedayati, Professor of Internal Medicine at UT Southwestern and first author of the study, which was…

Photo

Nationwide cohort study

Can an aspirin a day keep liver cancer away?

A new study presented this week at The Liver Meeting held by the American Association for the Study of Liver Diseases found that daily aspirin therapy was significantly associated with a reduced risk in hepatitis B virus‐related liver cancer. Past research suggests that daily aspirin therapy — which is often prescribed to prevent cardiovascular disease — may also prevent the development of…

Photo

Side effects

Do common acid reflux medications promote chronic liver disease?

Approximately 10 percent of the general population take a proton pump inhibitor (PPI) drug to block stomach acid secretions and relieve symptoms of frequent heartburn, acid reflux and gastroesophageal reflux disease. That percentage can be as much as seven times higher for people with chronic liver disease. Researchers at University of California San Diego School of Medicine have discovered…

Photo

Medication quality

No clear evidence that most new cancer drugs extend or improve life

The majority of cancer drugs approved in Europe between 2009 and 2013 entered the market without clear evidence that they improved survival or quality of life for patients, finds a study published by The BMJ. Even where drugs did show survival gains over existing treatments, these were often marginal, the results show. Many of the drugs were approved on the basis of indirect (‘surrogate’)…

Photo

Personalized medication

Opioids often overprescribed

In a review of half a dozen published studies in which patients self-reported use of opioids prescribed to them after surgery, researchers at Johns Hopkins report that a substantial majority of patients used only some or none of the pills, and more than 90 percent failed to dispose of the leftovers in recommended ways.

Photo

Skin repair

Badly sunburned? Vitamin D can help

High doses of vitamin D taken one hour after sunburn significantly reduce skin redness, swelling, and inflammation, according to double-blinded, placebo-controlled clinical trial out of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center.

282 show more articles