Tissue

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Preventing long-term damage

How Covid-19 attacks lung tissues

La Trobe University researchers are the first in the world to characterize precisely how Covid-19 attacks lung tissues — an important step in preventing long-term damage.

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Digital pathology

Today’s tissue for tomorrow’s research

Specialist biorepositories are helping advance personalised medicine by supporting the availability of human tissue for research using digital pathology techniques. The pivotal role of the Glasgow…

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Nano science

Conductive hydrogel could replace brain tissue

Due to their tissue-like mechanical properties, hydrogels are being increasingly used for biomedical applications; a well-known example are soft contact lenses. These gel-like polymers consist of 90…

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Curbing collaterals

High energy radiotherapy ‘paints’ tumours, avoids healthy tissue

A radiotherapy technique which ‘paints’ tumours by targeting them precisely, and avoiding healthy tissue, has been devised in research led by the University of Strathclyde. Researchers used a…

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Regenerative medicine

Lab-grown ‘mini-bile ducts’ to repair human livers

Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can be used to repair damaged human livers. This is the…

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Freefrom Reversible Embedding of Suspended Hydrogels

A 'FRESH' way to 3D-print tissues and organs

Research into 3D bioprinting has grown rapidly in recent years as scientists seek to re-create the structure and function of complex biological systems from human tissues to entire organs. The most…

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Digital pathology

An exciting new era for tissue microarrays

A new generation of tissue microarrays are delivering more efficient and time-effective solutions to answering complex clinical and scientific questions. Sitting at the core of this new approach is digital pathology, allowing specific and targeted analysis of small areas of tissue.

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Tissue analysis

Infrared spectroscopy as a diagnostic tool

New techniques of infrared-based technology are showing strong potential for cost-effective tissue analysis. Peter Gardner, Professor of Analytical and Biomedical Spectroscopy at the University of Manchester, outlined how hyperspectral imaging coupled with sophisticated computer algorithms can identify and grade cancerous tissue, as well as offer an indication of prognosis. The technique, he…

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Hope for new skin grafts

3D printed living skin complete with blood vessels

Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin, complete with blood vessels. The advancement, published in Tissue Engineering Part A, is a significant step toward creating grafts that are more like the skin our bodies produce naturally. “Right now, whatever is available as a clinical product is more like a fancy Band-Aid,” said Pankaj Karande, an…

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Regeneration vs. osteoarthritis

Regrow cartilage in joints? Science says you can

Contrary to popular belief, cartilage in human joints can repair itself through a process similar to that used by creatures such as salamanders and zebrafish to regenerate limbs, researchers at Duke Health found. This process could be harnessed as a treatment for osteoarthritis. Publishing in the journal Science Advances, the researchers identified a new mechanism for cartilage repair.

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Tissue construct

A 'swift' way to 3D-print organs

Twenty people die every day waiting for an organ transplant in the U.S., and while more than 30,000 patients now receive transplants annually, another 113,000 are currently on organ waitlists. Many people see artificially grown human organs as the Holy Grail for resolving the organ shortage, and advances in 3D printing have led to a boom in using that technique to build living tissue constructs…

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After myocardial infarction

Patching up a damaged heart

Scientists in the UK have developed tiny patches of engineered heart tissue that have the potential to be implanted to help people recover from a heart attack. Measuring approximately 3cm x 2cm, the patches contain up to 50 million human-induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM). Yet, these are programmed to turn into working heart muscle that can beat and gradually be…

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Tissue model

How clots become firm in the presence of blood flow

Blood clotting is one of the most critical, protective processes in human physiology. When something goes wrong with clotting, either because there is too much clotting, leading to a stroke, or not enough, leading to internal bleeding, the outcome can be catastrophic. Now, University at Buffalo researchers have established an in vitro model of this process that will help clinicians improve…

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Collagen unter the microscope

Seeing the pattern beneath the skin

As the largest organ of the human body, our skin is astounding. It protects us from infection, endures radiation, senses temperature, and is flexible enough to withstand our everyday activities. What holds this all together is the protein we all know and love: collagen. In a paper published in Scientific Reports a team from Japan found for the first time that collagen in the skin is organized in…

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Cellular interactions

Repairing aged tissue by messing with the neighbors

Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce…

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Bioprinting

Producing tissue and organs through lithography

The production of artificial organs is a hot research topic. In the near future, artificial organs will compensate for the lack of organ donations and replace animal experiments. Although there are already promising experiments with 3D printers that use a „bio-ink“ containing living cells, a functional organ has never been created in this way. A European consortium coordinated by Dr Elena…

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Bioprinting

3D printing of biological tissue

The future of medicine is biological – and scientists hope we will soon be using 3D-printed biologically functional tissue to replace irreparably damaged tissue in the body. A team of researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB has been working with the University of Stuttgart for a number of years on a project to develop and optimize suitable…

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