Transplantations

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News • Preventing EBV reactivation

Liver transplantation: Finding the "sweet spot" of immuno-suppression

Dutch physicians have developed a system to determine the right dose of immunosuppressive drugs for patients to receive a donor liver - to prevent the activation of the Epstein-Barr virus.

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News • Cardiology research

Are hearts from Covid-19 positive donors safe for transplantation?

Donor hearts from people who were Covid-19-positive appear to be as safe for transplantation as those from people without Covid-19, according to a new short-term analysis.

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Article • LTX overview

Lung transplant surgery: last hope for patients with advanced lung diseases

Despite treatment, chronic lung diseases such as COPD or cystic fibrosis can become so severe that a lung transplant is necessary. Dr Urte Sommerwerck explains which patients might be considered for…

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Article • Keratoplasty

Corneal transplantation surgery: AI for an eye

Many consider our eyes to be the windows to the soul. Yet the cornea, the panes of these windows, sometimes need significant repair. Friso Heslinga, PhD, created artificial intelligence models to…

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News • Organ transplantation

New treatment could improve donor lung availability

Researchers at Lund University in Sweden and Skåne University Hospital have conducted an animal study bringing hope that more donor lungs could be used in the future.

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News • Donation after cardiac death

'Heart in a box' technology gives hope to transplant patients

A new heart transplant technique, which allows surgeons to transplant donor hearts that have stopped beating after death, is reducing waiting lists for patients in Australia and potentially around…

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News • Personalised aftercare

Immunosuppression after transplant: as much as necessary, as little as possible

After a liver transplant, patients have to take immune-suppressing drugs for the rest of their lives. These so-called immunosuppressants prevent the organ from being rejected. However, the drugs increase the risk of cancer and serious infections. They can also significantly impair kidney function and even lead to dialysis. In order to be able to give those affected as much immunosuppression as…

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News • Promising material

Organ transplantation: polymer coating reduces rejection rate

Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted. The polymer, developed by Prof. Dr. Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and Life Sciences Institute at the University of British Columbia, substantially diminished rejection of transplants in mice when…

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News • Donor organ analysis

New laser technique could improve liver transplant process

Handheld laser devices that help surgeons quickly spot liver damage could transform transplant procedures, research suggests. The non-invasive technique could provide medical staff with instant data on the health of donor livers and help them to identify which organs are suitable for transplant. If widely adopted, the light-based tool could allow more livers to be transplanted safely and…

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News • Outcome prediction

Deep learning to maximize lifespan after liver transplant

Researchers from the Canadian University Healh Network (UHN) have developed and validated a deep learning model to predict a patient's long-term outcome after receiving a liver transplant. First of its kind in the field of Transplantation, this model is the result of a collaboration between the Ajmera Transplant Centre and Peter Munk Cardiac Centre (PMCC). The study, published in Lancet Digital…

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News • Bioengineering

Producing transplantable livers in the laboratory

Researchers at the Human Genome and Stem Cell Research Center (HUG-CELL), hosted by the University of São Paulo’s Institute of Biosciences (IB-USP) in Brazil, have developed a technique to reconstruct and produce livers in the laboratory. The proof-of-concept study was conducted with rat livers. In the next stage of their research, the scientists will adapt the technique for the production of…

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News • Human cytomegalovirus in immunocompromised patients

Post-transplant HCMV infection: pre-emptive strike could save many lives

A potential new treatment to protect immunosuppressed patients from human cytomegalovirus (HCMV) has been discovered by scientists at the University of Cambridge. Their study shows that certain epigenetic inhibitors expose and help to destroy dormant HCMV infections, which often reactivate to cause serious illness and death in these vulnerable groups. Subject to clinical trials, their proposed…

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News • Donor organ assessment

New quality feature to predict kidney transplant failure

New research indicates that subtle structural features of donated kidneys from living donors may predict the risk of kidney transplant failure in recipients. The findings, which appear in an upcoming issue of JASN, may help clinicians as they evaluate the quality of organs at the time of transplantation. The quality of donated kidneys obtained from living donors is often inferred from their age,…

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