Laboratory/pathology

From clinical chemistry to digital pathology: Read more about how modern medical laboratories and procedures in pathology play a vital role in the detection and prevention of diseases and in medical research.

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Cervical cancer

3D imaging system accelerates cancer diagnosis

Researchers have developed a novel three-dimensional imaging system to diagnose cervical cancer faster, non-invasively and more efficiently than conventional methods.

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Going digital

How digital pathology is shaping the future of precision medicine

In recent years, technological and regulatory advances have made digital pathology a viable alternative to the conventional microscope. The obtention of a digital replica of the traditional glass…

Product of the month

VeinViewer® - Innovation in visualization

The VeinViewer® uses harmless near-infrared (NIR) light which is directed towards the patient’s skin. Haemoglobin in the blood absorbs the NIR and the surrounding tissue reflects it back to the…

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Lab medicine in the Netherlands

Digital pathology: From over-promising to a reality check

Almost five years ago, the plan to implement a wide-ranging digital pathology approach across the Netherlands began to take shape. As more labs across the country acquire digital pathology capability, with steps to create a strong and accessible image repository and a national image exchange platform, one of the project leaders, Professor Katrien Grünberg, offered an update and spoke of some challenges that still lie ahead. In a keynote presentation, ‘Digital Pathology going Dutch’ at the recent Digital Pathology and AI Congress in London, she also touched on the experience in Nijmegen, where she is Professor of Pathology and chair of the Department of Pathology at Radboud University Medical Centre (UMC).

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Adrenal cortical carcinoma (ACC)

Simple urine test could significantly improve adrenal cancer detection

Using a simple urine test alongside routine imaging for patients with adrenal masses could speed up adrenal cancer diagnosis, improving patient’s prognosis and reducing the need for invasive…

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Coronavirus

Lab-made virus mimics COVID-19 virus

Airborne and potentially deadly, the virus that causes COVID-19 can only be studied safely under high-level biosafety conditions. Scientists handling the infectious virus must wear full-body…

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COVID-19

Novel viral transport media for testing of multiple infectious diseases

EKF Diagnostics, the global in vitro diagnostics company, announces that it has added a novel viral transport media for the safe sample handling and testing of multiple infectious diseases from a…

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COVID-19 diagnostics

SARS-CoV-2 IgG antibody test receives FDA Emergency Use Authorization

Beckman Coulter announced that its Access SARS-CoV-2 IgG assay has received Emergency Use Authorization (EUA) from the U.S. Food & Drug Administration (FDA). Beckman Coulter has already shipped…

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Pipettes

Robot automates COVID-19 testing

A Danish pipetting robot is automating Covid testing processes in hospitals around Europe. The robot, called flowbot ONE, significantly reduces the time it takes for laboratories to produce results…

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First steps

On the way towards a digital histopathology service

The Norfolk and Norwich University Hospital (NNUH) has taken the first steps towards establishing a digital histopathology service, which will help to improve cancer care. New systems are being…

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Rapid diagnostics

A test diagnoses COVID-19 virus in 30 minutes

A new diagnostic test can detect the RNA of SARS-CoV-2, the virus that causes COVID-19, in urine, blood, saliva or mouth swab samples in just 30 to 45 minutes, according to a new study in the…

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Viral on­co­logy

Kaposi Sarcoma: Answers to a longstanding enigma

The oncogenic herpesvirus (HHV8 or KSHV) causes a cancer known as Kaposi’s Sarcoma. An international team of scientists led by the University of Helsinki has discovered key factors that control the…

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HNSCC diagnostics

Head and neck cancer: Novel prognostic biomarker could double survival

A recent study conducted by the Faculty of Medicine at The Chinese University of Hong Kong (CU Medicine) discovered a novel genetic biomarker which can predict the survival of head and neck cancer…

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Pathological regression of lymph nodes

Improved grading system to predict esophageal cancer survival

A group of researchers led by Osaka University established a new pathological grading system to evaluate the therapeutic effect of neoadjuvant chemotherapy (NAC) for metastatic lymph nodes (LNs)…

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Triple-negative breast cancer

Target validation for drug development against aggressive breast cancer

At around 30.5 percent, breast cancer is the most common cancer among women in countries of the industrialized world. The number of cases has doubled since the 1980s: about 69,000 times a year women…

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Human-bacterial symbiosis

The value of the human microbiome

The human species maintains symbiotic relationships with a multitude of microbial organisms that colonise the inside as well as the surface of the body. Scientists, for a long time, underestimated…

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Blood testing for astronauts

Health in space: a mini-lab for zero gravity

Nanoelectronics and digital technologies R&D and innovation hub Imec recently received NASA funding to test a new technology in a gravity-free environment. Eventually, this will enable astronauts to perform blood tests to monitor their health. We discussed the project and technology with Nicolas Vergauwe, CEO of miDiagnostics, the Leuven firm that developed the diagnostic device, and Susana B…

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Spreading quality pathology in Canada

Building a telepathology network

Following success of telepathology in the eastern region of Quebec, the service is set to be further expanded across its remote areas. There are also moves towards a fully digital service at some sites, to introduce tele-autopsy into remote regions and extend the geographical coverage further across the region. The latest developments were outlined at the Digital Pathology and AI Congress in…

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Digital pathology

VIPR: Deep learning for small cohorts

To investigate rare diseases, applying image-based analytics approaches, including the use of deep learning convolutional neural networks (DL-CNNs), can be a major challenge due to great difficulties in acquiring sufficient numbers of cases and associated digital image sets from the small cohorts typically available. To realise algorithms that are both effective and generalisable, conventional…

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Pathology informatics event

Panel Discussion on the use of digital pathology for remote diagnosis

Hamamatsu Photonics invites you to join us for a panel discussion with pathologist Matthew Hanna, MD and IT Manager Nikolas Stathonikos on Thursday, 9 July at 17:00 CET. In this rapidly evolving healthcare landscape triggered by COVID-19, pathology, and remote diagnosis have been elevated to critical topics. These two experts, representing both the clinical and information technology areas, will…

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Review sheds doubt

Major flaws in evidence base for COVID-19 antibody tests found

Major weaknesses exist in the evidence base for COVID-19 antibody tests, finds a review of the latest research published by The BMJ. The evidence is particularly weak for point-of-care tests (performed directly with a patient, outside of a laboratory) and does not support their continued use, say the researchers. Serological tests to detect antibodies against COVID-19 could improve diagnosis and…

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UK experts raise concerns

COVID-19 antibody tests: Not a game-changer after all?

A group of senior clinical academics and physicians are concerned about the rapid roll out of COVID-19 antibody testing in England and are publicly questioning how good the tests are - or even what they mean. In a letter to The BMJ, they argue that there is currently no valid clinical reason for large scale testing, test performance has not yet been adequately assessed, and testing risks…

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Sample analysis

Next-generation analytical lab software strengthens data exploration

Scientists in the life sciences can now benefit from upgrades to a suite of analytical software solutions with new features designed to enhance productivity, confidence and accuracy in numerous fields, including proteomics, food safety and biotherapeutic drug development. The latest suite of software strengthens laboratory workflows across a range of applications through expanded capabilities,…

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Predictive proteins

Biomarkers in COVID-19 patients could predict how ill they become

Researchers at the Francis Crick Institute and Charité – Universitätsmedizin Berlin have identified 27 protein biomarkers that could be used to predict whether a patient with COVID-19 is likely to become severely ill with the disease. People infected with SARS-CoV-2, the virus which causes COVID-19, respond differently. Some do not develop any symptoms, some need to be hospitalised and, for…

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Cancer research

Lymph node analysis to hunt down metastases

What makes tumor cells turn murderous? The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is investigating the mechanisms of metastasis formation – and searching for approaches for new treatments in the fight against cancer. Among other things, the research team at Fraunhofer ITEM has developed a method that enables them to analyze entire lymph nodes.

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From physical to computational staining

Deep learning accurately stains digital biopsy H&E slides

Tissue biopsy slides stained using hematoxylin and eosin (H&E) dyes are a cornerstone of histopathology, especially for pathologists needing to diagnose and determine the stage of cancers. A research team led by MIT scientists at the Media Lab, in collaboration with clinicians at Stanford University School of Medicine and Harvard Medical School, now shows that digital scans of these biopsy…

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COVID-19 detection

New analyzer detects virus antibodies in 20 minutes

Researchers at Hokkaido University have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.

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Coronavirus disease symptom

Exploring why COVID-19 makes people lose their sense of smell

Doctors have reported that partial or total loss of the sense of smell is often an early symptom of infection with SARS-CoV-2, the virus that causes COVID-19. Now, researchers reporting in ACS Chemical Neuroscience have shown that in mice, two proteins required for SARS-CoV-2 entry are produced by cells of the nasal cavity that contribute to odor detection. Moreover, larger amounts of the…

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Nephritis as a marker

Kidney an early warning sign for severe COVID-19 cases

A course of action to early detect and treat severe courses of COVID-19 infections has been developed by an expert-team of the University Medical Center Goettingen (UMG). A simple urine test is intended to help medical professionals to recognize warning signs of future decompensation of COVID-19 infections earlier. With the help of a few parameters, the treatment of imminent complications can…

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A more integrative approach to digital pathology

imCMS: The door to simple, cheap, reliable bio-stratification

Bringing molecular and digital pathology closer together through a more integrative approach can lead to clear advantages for diagnostic and research workflows. During the recent Digital Pathology and AI Congress (London) and in his keynote presentation ‘Molecular and digital pathology - the value of an integrative approach’ Professor Viktor Koelzer explored the benefits and paid particular…

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Going viral

Coronavirus clone produced in the lab

Researchers in virology and veterinary bacteriology at the University of Bern have cloned the novel coronavirus (SARS-CoV-2). The synthetic clones are being used by research groups worldwide to test corona samples, find antiviral drugs and develop vaccines as quickly as possible. The method developed in Bern can also be used in future to combat other highly infectious viruses. In the…

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Paradigm shift for point-of-Care-Testing

IT security of POCT devices – not everything is picture-perfect

Until recently, the major challenges surrounding Point-of-Care-testing (POCT) concerned the quality of the results and improving the reagents and the procedures in order to optimise patient care. In the modern clinical environment, however, IT security of POCT devices is becoming increasingly important, in Germany also due to new industry-specific safety standards under the Act on the Federal…

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Seeking an ideal lab life

New and old challenges in laboratory medicine

The Central Laboratory at the Medical University Hanover, Germany, is prepared to handle virtually any clinical chemistry task, from a routine test to the most complex analysis. Equipped with state-of-the-art technology and thanks to a high degree of automation, the team can process more than 3,000 specimens, mostly blood and urine, in a single day. Professor Ralf Lichtinghagen, European…

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