On-the-spot multi-task lab-on-a-chip

A new lab-on-chip system, the ivD-platform, which quickly determines, on site, the contents and parameters of biological samples, such as blood or saliva, with the help of immunoassay or DNA analysis, was presented at Biotechnica this autumn.

This system, which was developed by researchers in eight institutes of Germany’s Fraunhofer-Gesellschaft (Society), removes the current procedural delay caused because blood samples must be sent to a lab for analysis.
The lab-on-a-chip detects the analytes by the binding of antigens to antibodies. For DNA analysis the researchers utilise the double-strand to detect analytes.
Results are sorted on the basis of optical fluorescence signals or electrical signals.
Interestingly, the ivD-platform can be used for all kinds of bio-analytical problems, whilst previously it was necessary to use different, specially adapted biochips for different samples. Depending on the type of substance a customer wants analysed, different antigens are applied as binding agents. Also contrary to conventional examinations, just a few microlitres of the sample are sufficient for an immunoassay.
The Fraunhofer scientists have developed translation rules based on which units can be scaled down. Thus it is possible to calculate which antigens should be used, and in what amounts, for an optimum binding reaction for all kinds of samples. Apart from the different binding agents used, the ivD-platform is the same for all biological samples. Therefore it can be cost-effectively mass-produced, they point out, adding: ‘Thanks to the lab-on-chip system in future it will be possible to carry out fast sample analysis – and not only in human medicine: The ivD-platform can also be used in the fields of environmental, food and agricultural analysis.’

19.11.2008

More on the subject:
Read all latest stories

Related articles

Photo

Multiple tumor tissue biomarkers

MOSAICA: next-generation biopsy technology

A new biopsy tool will enable scientists and clinicians to simultaneously profile many biomarkers in cells and tissues.

Photo

Potential game-changer

Telling COVID-19 apart from influenza

Researchers have developed a diagnostic for SARS-CoV-2 that is capable of differentiating between COVID-19 and the garden-variety bug with fast turnaround.

Photo

Mini-microscopes

Are disposable robots conquering the labs of the future?

The team at the Institute of Medical Device Technology at the University of Stuttgart, Germany, is developing methods to produce top-quality medical devices at affordable prices. Professor Dr Peter…

Related products

Alsachim - Dosimmune immunosupressant Alsachim – kit (CE-IVD or RUO)

Clinical Chemistry

Alsachim - Dosimmune immunosupressant Alsachim – kit (CE-IVD or RUO)

Alsachim, a Shimadzu Group Company
Alsachim – Dosimyco immunosupressant reagent kit (RUO)

Clinical Chemistry

Alsachim – Dosimyco immunosupressant reagent kit (RUO)

Alsachim, a Shimadzu Group Company
Alsachim – Dosinaco anticoagulant reagent kit (RUO)

Clinical Chemistry

Alsachim – Dosinaco anticoagulant reagent kit (RUO)

Alsachim, a Shimadzu Group Company
ASP Lab Automation – Bench-top Decapper DeCap Pro

Sample Processing

ASP Lab Automation – Bench-top Decapper DeCap Pro

ASP Lab Automation AG
ASP Lab Automation – Recapper KapSafe

Sample Processing

ASP Lab Automation – Recapper KapSafe

ASP Lab Automation AG
ASP Lab Automation – Tube Sorter SortPro

Sample Processing

ASP Lab Automation – Tube Sorter SortPro

ASP Lab Automation AG
Subscribe to Newsletter