Breast cancer

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Alternative for mammography

Breast cancer screening: Does the future belong to the abbreviated MRI?

Is mammography still the best method for breast cancer screening? For a number of breast cancers, the latest scientific findings suggest otherwise. For more than a decade, Professor Christiane Kuhl MD, Director of the Clinic for Diagnostic and Interventional Radiology at the University Hospital RWTH Aachen, has researched the use of MRI in breast cancer screening. During a Bayer Healthcare…

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Distant metastasis-free interval explored

High-risk breast cancers: Mode of detection is linked to patient prognosis

Breast cancers that are detected in the interval between national screening programme mammograms have a worse prognosis than those detected at the time of a screening, even if they have the same biology, according to research presented at the 12th European Breast Cancer Conference. Analysis of results from over eight years’ follow-up of the international MINDACT randomised phase III clinical…

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TARGIT-IORT vs. EBRT

Breast cancer radiotherapy: A single dose is often enough

For most women with early breast cancer, a single dose of targeted radiotherapy during surgery is just as effective as conventional radiotherapy, which requires several visits to hospital after surgery. This combination of targeted radiotherapy (restricted to the area around the tumour) given immediately after surgery is called targeted intraoperative radiotherapy. Conventional radiotherapy…

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Breast cancer imaging

Should Gadolinium-based contrast agents be used in breast DTI?

The accuracy of breast cancer diagnosis via diffusion-tensor imaging (DTI) was equivalent both before and after the administration of a gadolinium-based contrast agent (GBCA), despite a value change in DTI parameters, finds a new research article. “However,” wrote first author Anabel M. Scaranelo of Princess Margaret Cancer Centre’s breast imaging division in Toronto, “the limitations in…

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G-quadruplexes

Quadruple DNA structures in breast cancer found

Four stranded DNA structures – known as G-quadruplexes – have been shown to play a role in certain types of breast cancer for the first time, providing a potential new target for personalised medicine, say scientists at the University of Cambridge. In 1953, Cambridge researchers Francis Crick and James Watson co-authored a study published in the journal Nature which showed that DNA in our…

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ER-positive tumour BC

Drug target for aggressive breast cancer found

A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast cancers. Around three quarters of women who have breast cancer have what are known as oestrogen…

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Triple-negative breast cancer

Target validation for drug development against aggressive breast cancer

At around 30.5 percent, breast cancer is the most common cancer among women in countries of the industrialized world. The number of cases has doubled since the 1980s: about 69,000 times a year women are diagnosed with breast cancer. Triple-negative breast cancer is a particularly aggressive form of breast cancer. As important receptors are missing here, treatment options and prognosis for such…

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Cross-presenting dendritic cells

How breast cancer sneaks past local immune defenses

Cold Spring Harbor Laboratory (CSHL) Associate Professor Mikala Egeblad and her colleagues describe a newly understood way by which breast cancer cells sabotage a key player in the body’s immune system. That key player provides local immune surveillance by activating killer T-cells, but if it cannot mature and do its job, breast cancer cells can escape detection from the immune system,…

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Ultrasound monitoring

'Smart bra' to detect early-stage breast cancer

Students from EPFL in Switzerland teamed up with startup IcosaMed to develop the SmartBra – the first piece of smart clothing that can be used for cancer prevention. “Our smart-clothing technology is designed to detect cancer at the earliest stages. It uses a non-invasive, painless method based on frequent ultrasound monitoring,” says Hugo Vuillet, one of the students on the development…

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Improving coronavirus diagnosis

COVID-19 detection tool launched

The world’s only online image-based COVID-19 diagnosis improvement tool for healthcare workers is launched by University of Sydney spinoff DetectED-X, drawing on its global experience and outcomes in breast cancer detection and patient cases from the coronavirus pandemic. The cloud-based technology will help doctors and radiologists diagnose cases faster and more accurately. Computed tomography…

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Enhancing cancer imaging

New contrast agent for early diagnosis of brain metastases

A group of researchers led by Leif Schröder from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent. To this end, the team uses a synthetic molecule that helps to detect the formation of new blood vessels, producing much more sophisticated…

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IGF-1

Breast cancer: Growth hormone identified as probable cause

A growth hormone called insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer, according to new research published in the leading cancer journal Annals of Oncology. IGF-1 is already known to encourage the growth and proliferation of cancer cells. Now, two analyses of information from several hundred thousand women enrolled in the UK Biobank study have…

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"SOLUS" imaging project

Breast screening breakthrough to end unnecessary biopsies

Scientists from the project SOLUS (Smart optical and ultrasound diagnostics of breast cancer) under the EU funding framework programme Horizon2020 have developed a non-invasive, multi-modal, imaging system that uses ultrasound and light technologies to easily differentiate between benign or malignant lesions – without having to perform a biopsy. Similar to a pregnancy ultrasound appointment, a…

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Altered chromosomes

Breast cancer: targeted therapy can lead to treatment resistance

If chromosomes are unevenly distributed or otherwise altered during cell division, this normally damages the daughter cells and impairs their viability. Not in cancer cells, however, in which chromosome instability can actually confer a growth advantage under certain circumstances. Moreover, as scientists from the German Cancer Research Center have now demonstrated in mice, changes in the…

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Zooming in

Breast cancer map reveals how mutations shape the tumour landscape

Scientists have created one of the most detailed maps of breast cancer ever achieved, revealing how genetic changes shape the physical tumour landscape. An international team of scientists, brought together by a £20 million Grand Challenge award from Cancer Research UK, has developed intricate maps of breast tumour samples, with a resolution smaller than a single cell. These maps show how the…

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Triple-negative forms impeded

Scientists stop breast cancer cells from spreading in the lab

Biologists have discovered a way to stop cells from one of the most aggressive types of breast cancer spreading in the lab. The study points towards new avenues of research to combat the devastating disease. The results of the study of Triple-Negative Breast Cancer by the team from the Universities of Manchester, Glasgow and Sheffield and funded by Breast Cancer Now are published in Oncogene.…

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After mastectomy

Promising approach for breast regeneration

A team of researchers from Osaka University, Kyoto Prefectural University of Medicine, and Toppan Printing Co., Ltd. succeeded in reconstructing adipose tissue balls (“mini-breasts”) with a functional vascular network using patient-derived cells, achieving a high graft survival rate in small animal models. So far, silicone breast implants were primarily used in breast reconstruction following…

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Preventive potential

Why eating yoghurt may stave off breast cancer

One of the causes of breast cancer may be inflammation triggered by harmful bacteria say researchers. Scientists say their idea – as yet unproven – is supported by the available evidence, which is that bacterial induced inflammation is linked to cancer. The paper in the journal Medical Hypotheses is by Lancaster University medical student Auday Marwaha, Professor Jim Morris from the…

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Carbon-13 hyperpolarised imaging

Using magnetised molecules to monitor breast cancer

A new type of scan that involves magnetising molecules allows doctors to see in real-time which regions of a breast tumour are active, according to research at the University of Cambridge. The research was now published in Proceedings of the National Academy of Sciences. This is the first time researchers have demonstrated that this scanning technique, called carbon-13 hyperpolarised imaging, can…

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Update improves testing

Breast cancer guideline identifies most promising therapies

The updated guideline for estrogen and progesterone receptor (ER/PgR) testing in breast cancer, published jointly by the College of American Pathologists (CAP) and the American Society of Clinical Oncology (ASCO), reaffirms much of the original guidance and has more specific recommendations for handling and reporting cases with low ER expression. Globally, more than 1 million women are diagnosed…

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DeepMind to help human radiologists

Google-powered AI spots breast cancer

A computer algorithm has been shown to be as effective as human radiologists in spotting breast cancer from x-ray images. The international team behind the study, which includes researchers from Google Health, DeepMind, Imperial College London, the NHS and Northwestern University in the US, designed and trained an artificial intelligence (AI) model on mammography images from almost 29,000 women.…

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Evolution of technology

The value of AI in breast screening

Although breast cancer (BC) mammography screening enables early detection of breast cancer, mammography presents issues such as variability between the radiology readings and shortage of radiologists. This area of medical imaging is where artificial intelligence (AI) could help make the biggest difference and improve patient outcome.

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