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Chemotherapy

Chemotherapy is used against various cancers and is often consideres as a last resort – especially if the cancer has metastasised. Since chemotherapy agents can cause severe side effects, research aims to make treatment more tolerable.

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News • Making tumours susceptible to chemo

Breast cancer: target protein may hold key to therapy success

A rare variant of a protein present in nearly all human cells may hold the key to improving the effectiveness of breast cancer treatment, according to University of Manchester research.  

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News • Trial finds improved survival rates

Pancreatic cancer: chemotherapy before surgery brings benefits

Treating pancreatic cancer patients with chemotherapy before surgery significantly improved 1-year survival rates compared to immediate surgery, a randomised clinical trial has found.

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News • Glioblastoma treatment approach

'Zapping' brain cancer cells shows surprising benefits

Canadian researchers have developed a new method of killing brain cancer cells while preserving the tissue around it. A remarkable side-benefit: chemotherapy of the cancer suddenly becomes possible.

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News • New treatment approach

Colon cancer: Overcoming chemotherapy resistance

Colorectal cancer is one of the most common cancers. A team from the University of Geneva has found an alternative for patients who have developed resistance to chemotherapy treatments.

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News • New study

Can physical exercise enhance the effect of chemotherapy against breast cancer?

Many women diagnosed with breast cancer can be cured with surgery, radiotherapy and medical treatment. Swedish researchers explore whether physical exercise can support the anti-tumour effects.

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Article • Cryotherapy substitute

The surprising applications of ice cream in healthcare

From treat to treatment: Polish researchers explore the medical benefits of ice cream – despite the semi-serious presentation, a topic with surprising relevance for patients undergoing chemotherapy.

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News • Chemotherapy approach

New receptor insights might leave cancer bitter

Bitter taste receptors do not only support humans in tasting. They are also found on cancer cells. A team led by Veronika Somoza from the Faculty of Chemistry at the University of Vienna and the German Leibniz Institute for Food Systems Biology at the Technical University of Munich has investigated the role they play there. For this purpose, the scientists compiled and evaluated extensive…

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News • Ductal adenocarcinoma

Pancreatic cancer ‘priming’ may make chemotherapy more effective

A new approach to ‘prime’ the tumour environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer. In preclinical models, a team at the Garvan Institute of Medical Research could enhance the tumours’ response to chemotherapy by reducing the stiffness and density of the connective tissue known as the stroma,…

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News • DNA damage causes AML

Cancer chemotherapy side-effects on blood cell development

By analysing secondary acute myeloid leukaemias, researchers at the Institute for Research in Biomedicine (IRB) Barcelona have detected mutations caused by platinum-based chemotherapies in cells that were healthy at the time of treatment. Treatment with chemotherapies influences the development of blood cells, favouring clonal hematopoiesis from cells with pre-existing mutations. The study has…

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News • Combined chemotherapy

Pancreatic cancer: New treatment promising for older patients

Pancreatic cancer is a disease of the elderly: the average age of patients is 72. In Austria, about 1,600 people are diagnosed each year. Since pancreatic cancer has no specific symptoms, it is not usually diagnosed until the tumor is locally advanced or has already metastasized. Once the tumor has metastasized, it is usually no longer treatable by surgery or radiotherapy. In addition, the drug…

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News • Cancer care

Remote 24-hour monitoring shows promise in chemotherapy patients

Remote 24-hour monitoring for cancer patients receiving chemotherapy helps to better manage side effects and improve quality of life, finds a study published by The BMJ. The researchers say remote monitoring can provide a safe, secure, and “real time” system that optimises symptom management and supports patients to remain at home - and is particularly relevant in the context of the Covid-19…

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News • Neoadjuvant chemotherapy

Breast cancer: New test predicts therapy success

In a collaboration with the Faculty of Statistics at TU Dortmund and the University Medical Center in Mainz, a research team at the Leibniz Research Centre for Working Environment and Human Factors in Dortmund (IfADo) has developed a test that can be used to predict the success of therapy for breast cancer. Breast cancer is one of the most common tumour diseases worldwide. One in eight women will…

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News • Mammacarcinoma study

Breast cancer: finishing treatment soon after diagnosis increases survival

Research from Cleveland Clinic in the U.S. and Cleveland Clinic Abu Dhabi in the U.A.E. has found a decrease in patient survival rates when treatment options – surgery, chemotherapy and radiation – are completed more than 38 weeks from the time of diagnosis. The observational study, which included more than 28,000 breast cancer patients registered in the American National Cancer Database, is…

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News • Chemotherapeutic delivery

Bowel cancer: Nanotechnology offers new hope

Bowel cancer survival rates could be improved if chemotherapy drugs were delivered via tiny nanoparticles to the diseased organs rather than oral treatment. That’s the finding from Indian and Australian scientists who have undertaken the first study, using nanoparticles to target bowel cancer, the third most common cancer in the world and the second most deadliest.

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News • Biological evidence

Scalp cooling protects hair from chemotherapy

A study reveals that scalp cooling physically protects hair follicles from chemotherapy drugs. It is the world’s first piece of biological evidence that explains how scalp cooling actually works and the mechanism behind its protection of the hair follicle. The data was part of an innovative hair follicle research project carried out by the dedicated Scalp Cooling Research Centre based at the…

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News • New mechanism discovered

UPR: Stress raises cancer cells' chemo resistance

Resistance of cancer cells against therapeutic agents is a major cause of treatment failure, especially in recurrent diseases. An international team around the biochemists Robert Ahrends from the University of Vienna and Jan Medenbach from the University of Regensburg identified a novel mechanism of chemoresistance which has now been published in "Nature Communications". It is driven by…

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Sponsored • Screening for the use of 5-FU anti-cancer drug

Fully-automated DPD deficiency testing

Each year almost 80,000 new patients in France alone receive fluoropyrimidines, a group of anti-cancer drugs including 5-FU which is normally administered intravenously to treat digestive, breast and head and neck cancer. However, fluoropyrimidines-based chemotherapies can cause severe toxicities (incidence at around 20%) and sometimes lethal toxicity (incidence between 0.1 and 1%) with part of…

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