Competition

Olympus Image of the Year – Celebrating art in science

Olympus’ Image of the Year Award for light microscopy in Europe recognizes the very best in life science imaging. Inspired by the beauty and breadth of images submitted for Image of the Year 2017,…

Combined power

LC-MS research and routine use

LC/MS, i.e. the combination of liquid chromatography (LC) with mass spectrometry (MS) – an analytical method developed primarily for environmental analysis and live science – remains a keen topic…

Prostate cancer

Liquid biopsy predicts therapy beneficiaries

Two blood tests can predict which subset of men with advanced prostate cancer will likely not benefit from anti-androgen therapies, providing doctors and patient added clarity on treatment options, according to a study led by Duke Cancer Institute.

New major epidemics?

Two gene mutations transform harmless bacteria into dangerous strains

Since 2013, a new strain of meningococcal bacteria has spread rapidly in Niger and Nigeria, leading to large-scale outbreaks of meningitis. Analysis of the genetic material shows that with just two…

When the phosphate decides...

Defense against viruses or autoimmune disorder?

The first defense line of the body against virus infections is composed of so-called restriction factors. SAMHD1, one of such restriction factors, does not only play a role in the defense against…

Pregnancy

Blood test can predict premature birth

Measuring RNA fragments in a pregnant woman’s blood gives a reliable estimate of the baby’s due date and can predict if the baby will arrive prematurely, a Stanford-led team has shown.

Gene editing

CRISPR system embeds images in DNA

A research team in the United States has developed a revolutionary technique that has encoded an image and short film in living cells. Scientists at the Wyss Institute for Biologically Inspired…

Fighting infections

‘We are sitting on a ticking time bomb’

Multidrug-resistant organisms (MDRO) are keeping infection specialists worldwide on their toes. One of these specialists travelled all the way from Leipzig to India to gain insights in one of the…

Medical technology

Genrui presents latest products

Genrui Biotech Inc., one of the leading Chinese developers and manufacturers of IVD equipment and reagents, present their latest POCT devices at the China International Medical Equipment Fair (CMEF).…

Mass spectrometry

Analytics meets diagnostics

Up to the early 16th century, essentially medical diagnostics was limited to uroscopy – the observation of a urine sample in a uroscopy flask with a candle providing light. One hundred years later,…

Mutated DNA in blood

Liquid biopsy detects tumour changes in real time

New findings from a scientific collaboration between the German Cancer Research Centre (DKFZ), the National Centre for Tumour Diseases (NCT) Heidelberg and the Thoraxklinik Heidelberg suggest liquid…

Antibiotic resistance

A strain of multidrug-resistant Escherichia coli is on the rise

Antibiotic resistant bacteria lead to infections that are difficult to treat, particularly in hospitals. Multidrug-resistant Escherichia coli bacteria which have developed special enzymes that render…

Risk assessment

Predictive potential of Big Data in the lab

Big Data can be a critical tool in helping clinicians develop advanced patient health risk assessment and stratification models as well as leading to a new level of patient empowerment. Professor…

Antimicrobial resistance

What to do when antibiotics are taken like candy?

The need to do more to combat resistance in Germany was keenly emphasised by delegates at the VDGH (The German Diagnostics Industry Association) event held in Berlin this May. Only the answer, or at…

The EFLM Strategic Conference

Placing the medical lab in a future landscape

The need to ensure that laboratory medicine can meet the future challenges of a rapidly changing healthcare environment sits at the core of an innovative strategic conference for this sector. The…

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Single nucleotide polymorphism

Biosensor chip detects genetic mutation with higher sensitivity

A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism (SNP) and send the results in real time to a smartphone, computer, or other electronic device. The chip is at least 1,000 times more sensitive at detecting an SNP than current technology. The advance could lead to cheaper, faster and…

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Heard at the 14th ECDP in Helsinki

Digital pathology: Sometimes AI can outperform experts

Machine learning is adding a new dimension to pathology and already outperforming experts during some tasks, according to several speakers at the 14th European Congress on Digital Pathology (ECDP) who revealed up-to-date developments. However, whilst AI is set to herald a new future for digital pathology, Johan Lundin, associated professor for biomedical informatics and research director at the…

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Liquid chromatography-mass spectrometry

Increasing productivity and throughput in the lab

Liquid chromatography-mass spectrometry (LC-MS) has become a highly valued procedure in state-of-the-art laboratories – among them the Dr. Wisplinghoff Laboratory in Cologne, which adopted the method a decade ago. In its forty years, the organisation has provided physicians with the entire clinically relevant analysis spectrum of laboratory medicine, pathology, transfusion medicine as well as…

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Sepsis treatment

Bedside testing can prevent antibiotic-induced hearing loss in new-borns

More than a million neonatal deaths worldwide each year are estimated to be due to sepsis. In the UK there are approximately 90,000 admissions to neonatal intensive care units per year. Nearly all these patients receive antibiotic therapy during their hospital stay, but babies with a specific genetic change can suffer irreversible hearing loss as a result. Now, in a collaboration between…

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Product of the Month

cellSens 2.1 – More Imaging for Less

Olympus cellSens 2.1 offers improved capabilities for flexible camera and microscope control and enables researchers to create sharp, noise-free images in less time. Helping to drive microscopy forward, cellSens 2.1 speeds up image analysis and features new image acquisition tools at a lower cost. In addition, existing cellSens users may be eligible for a free upgrade to cellSens 2.1. cellSens…

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High-throughput system

Speeding up flow cytometry to discover new drugs

A new SLAS Discovery original research article available now for free ahead-of-print, researchers from the Genomics Institute of the Novartis Research Foundation (GNF) highlights a diversity of approaches that their automated high-throughput flow cytometry has enabled for phenotypic drug discovery. Flow cytometry is a very powerful tool that has been used for decades and allows for…

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Status quo and recent developments

What's new in liquid chromatography-mass spectrometry?

European Hospital has recently focused on the development of liquid chromatography-mass spectrometry (LC-MS) for use in analytical/medical diagnostics. Dr Stavros Kromidas, an expert in high-performance liquid chromatography (HPLC) and author of several specialist books, has published his latest book ‘The HPLC-MS Handbook for Practitioners’. We interviewed him about this and a new technique…

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Pathology testing

The right tests – for the wrong reasons?

Figures show that the rates of pathology testing are continuing to rise despite a backdrop of financial constraint within the NHS. General practitioner (GP) Dr Jessica Watson has expressed concern that some tests are being carried out for the wrong reasons – often for a non-medical purpose – and that unnecessary tests are causing increased anxiety and uncertainty rather than offering…

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Innovation

Siemens Healthineers debuts new thermocycler and AI-powered interpretation software

At the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Fast Track Diagnostics, a Siemens Healthineers company, launches a new molecular thermocycler, the Fast Track cycler, and the complementary new FastFinder software. The Fast Track cycler is a compact platform that enables laboratories of all sizes to implement molecular testing with simplicity and speed…

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Innovation

A real time saver at the highest level of molecular diagnostics – the eazyplex® platform!

This platform enables you to perform high class molecular diagnostics at an unbelievable speed. All assay run times are as short as 15 to 30 minutes, depending on the sample material. The lyophilised reactions are shippable and storable at room temperature and ready to use, with a shelf life of 18 month. Due to the robustness of the polymerase you don’t need any DNA extraction. The…

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Medication development

Support from the other end of the world

Partners who could hardly be further apart – yet have a lot in common – have united to fight resistant pathogens. The International Consortium for Anti-Infective Research (iCAIR) was founded last January. Hanover Medical School (MHH) and the Fraunhofer-Institute for Toxicology and Experimental Medicine (ITEM) are participants in Germany. The third partner, the Institute for Glycomics (IfG) at…

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Value based lab medicine

Meeting the challenge of modern laboratory demands

Faced with the constant challenge of increasing demand and a backdrop of falling reimbursement, Mayo Clinic in the United States has adopted an innovative and proactive approach to managing its laboratory services. That has seen the US-based medical giant embrace a variety of tools and reference materials to aid clinician decision making, improve care and lower costs. Dr Curt Hanson, Chief…

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Product launch

Horiba Medical expands Hemostasis range

Horiba Medical is proud to announce the development of its offer with the extension of the Hematology portfolio into the Hemostasis field. For over 30 years, Horiba Medical has developed its recognized proficiency in blood cell analysis. This scientific knowledge, innovation, leadership and cutting edge technology has been utilized to propose a new and comprehensive range of systems and reagents…

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Innovative test

Diagnosis of bacterial vaginosis

Bacterial vaginosis (BV) is a common infectious disorder that affects millions of women worldwide. Women of all ages are at risk for BV and its complications, which include a greater susceptibility to sexually transmitted infections (STIs) such as herpes simplex virus and HIV. If left undetected and untreated, BV can increase a woman's risk of upper genital tract infections such as pelvic…

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Illumination

Reliable Diagnoses with Olympus True Color LED

Ensure reliable diagnoses in pathology with Olympus’ market-leading LED technology. True Color LED illumination is a durable, bright light source especially designed to closely match halogen illumination, delivering accurate color reproduction every time. The light produced by many LED designs does not allow reliable color distinction in a specimen. In fact, when compared to halogen light…

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Joining strengths

Vaccination and infection control: Two pillars of prevention

Synchronised efforts between preventive medicine and immunology enable powerful vaccination strategies in a Spanish seniors hub. Efficient prevention also comes with proper infection control and regulating antibiotics use in primary care, local expert in preventive medicine explained in an exclusive interview with EH. Working in a small structure has its perks, one of which is that departments…

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Automation

Mass spectrometry is advancing laboratory practice

Mass spectrometry is moving laboratory medicine to increasingly automated discrete analysis methods, resulting in ever faster and more reliable results. It is also leveraging economies of scale as an increasingly cost-effective tool, says Craig Webster, Consultant Clinical Scientist and Clinical Lead, Department of Biochemistry and Immunology at Heartlands Hospital in Birmingham. Speaking about…

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Economies of scale

Lab medicine: Network consolidation continues

Laboratory networks are consolidating across the globe as they seek to deliver a more efficient and cost effective service. The latest developments on several continents were outlined at the FiLM 2018 – Frontiers in Laboratory Medicine congress held in Birmingham, UK in January. With consolidation viewed as a way to deliver economies of scale, it was a recurring theme at the congress with…

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Clinical practice

LC-MS/MS enters the medical laboratory

Over the last four years, Dr Thomas Stimpfl and his team have integrated mass spectrometry into routine analysis. The analytical technique liquid chromatography–mass spectrometry (LC-MS) combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analytical capabilities of mass spectrometry (MS). LC- and MS procedures were not originally developed for…

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Manufacturers vs. bureaucracy

‘We will master this problem’

Manufacturers are required to prevent so-called anomalous use. This includes, for instance, the use of cuvettes that are not licensed in products like Teco’s Coatron-X. Norms and directives are the backbone of medical devices manufacture. Frequent updates keep them current, but also often create unforeseen problems, especially for smaller and medium-size companies, because the bureaucracy is…

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