Laboratory/pathology

From clinical chemistry to digital pathology: Read more about how modern medical laboratories and procedures in pathology play a vital role in the detection and prevention of diseases and in medical research.

Photo

Making the invisible visible

New method opens unexplored realms for liquid biopsies

Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients’ blood and urine. These “liquid biopsies” are less…

Photo

Heroin, fentanyl, carfentanyl

Mass Spec detects illicit drugs

As a synthetic opioid approved for treating severe pain, fentanyl has shown clear medical benefits. However, in recent years, continuous abuse of fentanyl and its derived analogues substances has…

Photo

Liquid chromatography/mass spectrometry

LC-MS: Calling for easy-to-use platforms

Liquid chromatography/mass spectrometry (LC-MS) is an established powerful tool in routine clinical use and clinical research. However, to further capitalise on its benefits, instrument and…

Photo

Oestrogen-receptor positive, HER2-negative

Test determines most effective treatment for breast cancer

A breast cancer test has been found that helps doctors make treatment decisions for some breast cancer patients, following research carried out at Queen Mary University of London and funded by Cancer Research UK. The test was successful in predicting whether chemotherapy would be beneficial for patients with the most common type of breast cancer (oestrogen-receptor positive, HER2-negative), thereby helping to direct patients with a high-risk of metastasis to chemotherapy, while allowing lower-risk patients to opt out of the treatment and its potential side effects. Approximately 85 per cent of breast cancer patients are now diagnosed as oestrogen receptor positive, which means that the cancer grows in response to the hormone oestrogen. Doctors treating the majority of these women…

Photo

Post-cancer impairment

'Chemobrain': New biomarkers found

Cognitive impairment associated with cancer, also known as “chemobrain”, has gained recognition as a complication of the disease and its treatment, as it can negatively affect the daily lives of…

Photo

Digital pathology & AI

Unleashing the power of digital pathology for precision medicine

Digital pathology, combined with the power of Artificial Intelligence (AI), is one of the most promising fields for the delivery of precision medicine. In the first keynote address for the 5th…

Photo

Targeted treatment

Cancer: Blood sample to help select the right early phase clinical trials

Scientists could help match cancer patients with no other treatment options to clinical trials with experimental medicines, by analysing the genetic faults in a sample of their blood. The…

Photo

Flow cytometry lab

New ClearLLab IVD Reagents launched

Beckman Coulter is launching the ClearLLab 10C System for the clinical flow cytometry lab. The new system is the first 10-color IVD panel of immunophenotyping reagents cleared by the Food and Drug…

Photo

Total Laboratory Automation

TLA sets new standard for turnaround time

Beckman Coulter announced that the latest addition to its market-leading automation portfolio, the DxA 5000 total laboratory automation (TLA) solution has achieved European CE Mark and China Food and…

Photo

New hematologic biomarker

FDA clearance for early sepsis indicator

A major milestone on its strategic mission to lead in sepsis diagnostics, Beckman Coulter announced that its Early Sepsis Indicator has received 510(k) clearance from the U.S. Food and Drug…

Photo

Antimicrobial resistance

Apocalypse postponed: upcoming antibiotics bring hope

Antimicrobial resistance is a global issue, with 700,000 deaths per year and 10 million expected deaths by 2050, according to predictions. Appropriate antimicrobial therapy can help to save lives,…

Photo

Two years earlier

Breast cancer: blood test could detecting relapse earlier

Research has revealed that a new blood test is able to detect disease relapse up to two years earlier than imaging in patients with early-stage breast cancer. The research, carried out by the…

Photo

Infectious disease

Sensor technology could detect Dengue fever earlier

Researchers from the University of Bath are developing a new tool for detecting the presence of Dengue fever early on, helping prevent people from suffering potential life-threatening complications.

Photo

MRSA

Decolonization protocol can prevent dangerous infections

Antiseptic soap, mouthwash, and nose ointment after hospital discharge reduced infections and infection-associated hospitalizations due to MRSA in high-risk patients. Hospital patients who have…

Photo

Emergency medicine

D-dimer POCT for DVT considered ‘game-changer’ in ambulatory care

Radiometer Limited’s AQT90 FLEX analysers have been used in a successful trial to asses D-dimer point-of-care testing (POCT) for suspected lower limb deep vein thrombosis (DVT). The editorial…

Photo

NSCLC

Liquid biopsy as effective as tissue biopsy for non-small cell lung cancer

Test more accurately identifies four mutations for which FDA-approved drugs exist and offers faster turn-around time between initial testing and commencement of therapy.

Photo

Haematology analyser

Meet the innovation

The new Yumizen H2500 is a high-end haematology analyser with CBC, 8-DIFF, NRBC, reticulocytes, optical platelets and Body Fluids (CE). Full automation for demanding haematology diagnostics, can be…

Photo

Beyond ecomics

How Axonlab puts social responsibility into practice

Since the firm was created almost 30 years ago, Roland Steger, the founder and CEO of Axon Lab AG, always regarded it as important for it to help resolve social challenges as well as achieving…

Photo

Spectrophotometry

1 measurement, 1000 different results

Of course every lab needs a spectrophotometer to measure its DNA, RNA or protein concentrations. In most cases, this is a small and easy-to-use instrument. Normally you pipette approximately 1 µl of…

Products from Labbook

Shimadzu – Axima iDplus Performance

Mass Spectrometry

Shimadzu – Axima iDplus Performance

Shimadzu Europa GmbH
SARSTEDT - Low Retention Pipette Tips

PIPETTE TIPS

SARSTEDT - Low Retention Pipette Tips

SARSTEDT AG & CO. KG
Shimadzu – LCMS-8060 CL

Mass Spectrometry

Shimadzu – LCMS-8060 CL

Shimadzu Europa GmbH
Visiopharm – ONCOTOPIX Quantitative Image Analysis

Information technology

Visiopharm – ONCOTOPIX Quantitative Image Analysis

Visiopharm A/S
T&O LabSystems – ATRAS (RS)

Sample Processing

T&O LabSystems – ATRAS (RS)

T&O LabSystems
Greiner – Vacuette Urine CCM Tube

Urine Screening

Greiner – Vacuette Urine CCM Tube

Greiner Bio-One
Photo

Point-of-Care Testing

POCT: A coordination office is necessary

Point-of-care testing (POCT) is complex and its development continues due to digitisation in healthcare and increasing international partnerships among the healthcare actors. In a hospital, a number of factors need consideration to fully exploit the potential of bedside testing. POCT instruments and analysis methods must be thoroughly validated and quality assurance processes be in place.…

Photo

Hematology

Early sepsis indicator helps identifying patients at risk

The critical element of testing for sepsis lies not so much in the location but in the timing and rapidity of results, according to Professor Jeannine T. Holden from Beckman Coulter Early identification enables treatment protocols to be delivered more quickly, offering better patient outcomes. Those most at risk, suggests Holden, are not patients within the intensive care unit – who are already…

Photo

Flow cytometry

Living cells – the essential biomarker

The team of the Heinz Nixdorf Chair of Biomedical Electronics at the Technical University of Munich focuses on innovative diagnostic tools to accelerate the development towards personalized medicine. Therapies tailored to the individual patient – this is the future not only of oncology but of many medical disciplines. “At this point, however,” concedes Professor Dr Oliver Hayden,…

Photo

High-performance tube sorting

Easy access: The new lightweight target bin with permanent display

More than 16 years of experience in the complex matter of workflows within clinical labs leads to the latest generation of ASP SortPro tube sorter. To make the investment in sorting devices efficient, these must be integrated perfectly into the workflow. The ASP team sold hundreds of tube sorters to clinical labs and hospitals worldwide. In all these installations the German engineers have…

Photo

Lab equipment

Citrine MS/MS – your Medical Diagnostic mass spectrometer

In the modern diagnostic lab, analytical challenges demand increased sensitivity, speed, robustness and reliability of any diagnostic system, and mass spectrometry is no different. Designed and manufactured with industry-leading technologies, Citrine meets these challenges head on, giving you confidence in your results and the best possible service to your patients. Citrine MS/MS from SCIEX…

Photo

Chemotherapy

5-FluoroUracil: Curing or killing the patient?

Fluoropyrimidine-based chemotherapies are widely used, at least in the European area, for treating various types of cancer including digestive, breast, throat and brain cancer. Fluoropyrimidines are a group of anticancer drugs including the well-known 5-FluoroUracil (5-FU) and the prodrug capecitabine. Fluoropyrimidine-based treatment can lead to severe toxicities or even lethal toxicity, but…

Photo

To the core

Mass spec needs experienced operators

As mass spectrometry proves to be a more consistent and accurate tool in biochemical measures, with acknowledged advantages over immunoassays, its role in diagnostics has escalated. Headed by Professor Ruth Andrew, the pioneering Mass Spectrometry Core Facility at the University of Edinburgh, aims to offer researchers access to expert scientists and specialist resources to support clinical…

Photo

Induced pluripotent stem (iPS)

Researchers find way to generate stem cells more efficiently

Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new and promising possibilities in precision medicine. To create them requires transforming a cell of one type, such as skin, into something of a blank slate, so it has the potential to become virtually any other kind of cell in the body, useful for regenerative therapies for…

Photo

Digital pathology

Bridging the gap between pathologist and algorithm

Digital pathology can gain huge benefits from rapid image search and the effective extraction of knowledge from large medical archives via artificial intelligence (AI). It facilitates identification of anatomical and pathological similarities, significantly enhances the clinical workflow, and ultimately paves the way for more informed diagnosis and better patient outcome. Effective archive…

Photo

Post-analytical interpretive tools

Towards a clearer view of complex lab results

Interpretation of complex profiles of laboratory results can be significantly improved via multivariate pattern recognition software. A multivariate pattern recognition software, developed by a team led by Dr Piero Rinaldo at Mayo Clinic in Rochester, USA, aims to integrate results to diagnose a particular condition in a single score, in an objective evidence-based way that is open to worldwide…

Photo

Mass spectrometry in patient care

LC-MS/MS: Why qualitatively high-value analysis is cheaper in the end

In the past, we repeatedly focused our attention on developments in the clinical application of mass spectrometry-based methods in patient care. Various aspects became significant. Today, the use of Liquid Chromatography Triple Quad Mass Spectrometry (LC-MS/MS) for therapeutic drug monitoring (TDM) can be considered today’s standard, although classically applied immunoassays continue to be…

Photo

Genetics

Sequencing methods – unfold the full potential for hospitals

Gene sequencing has been progressing in leaps and bounds over the past few years. The process of determining the order of nucleotides in DNA has become faster and more precise. Moreover, today both microbial DNA and host DNA can be identified in the blood sample of an infected patient, isolated and sequenced. “We are facing a technological revolution, but we still struggle with actually…

Photo

New staining technology

Staining is an art – ColorAX2 will become your favourite artist

ColorAX2 with its new staining technology offers you low staining reagents consumption. The compact, lightweight and autonomous system features 10 independent staining chambers and allows easy and clean procedures. The unique technology of ColorAX2 prevents cross-contamination and significantly reduces the consumption of reagents and waste. Besides it helps you reduce your operation costs. The…

Photo

Infection control

Knowledge is one thing - implementation another

Insufficient knowledge of infection control, resulting in insufficient compliance, increases the risk of hospital acquired infections (HAIs) and multiresistant pathogens that put patients at risk. At the 2019 Annual General Meeting of the German Society for Hygiene and Microbiology e.V. (DGHM) in Göttingen, Professor Frauke Mattner, Senior Consultant at the Institute of Hygiene, Kliniken der…

Photo

Carbapenemase producing enterobacteriaceae

Detecting drug-resistant CPE quickly is still a challenge

Early detection and confirmation of carbapenemase-producing enterobacteriaceae (CPE) are essential when choosing the appropriate antimicrobial therapy and to implement infection control measures. Here, a leading Spanish microbiologist reviews an arsenal of tools currently available to clinicians. Resistance to beta-lactam antibiotics in enterobacteriaceae (EBc) is due to one or more of these…

Photo

Hospital hygiene

Nosocomial infections: a positive trend, but...

Hospital hygiene and how Germany compares in a European survey is somewhat divisive. Some believe Germany does well, whilst others emphasise the need to improve and for a stronger alignment with countries such as the Netherlands. As hygiene specialist Professor Petra Gastmeier, at the Institute of Hygiene and Environmental Medicine in Charité University Medical Centre Berlin, pointed out:…

Photo

Blood transfusions

Donor organs become immunologically invisible

The safety of blood transfusions is questioned again and again by the mass media. Sometimes ‘bad’ blood causes infections; sometimes a transfusion leads to cancer years later. The fact is that transfer blood is subjected to the highest safety standards – there are very clear statutory regulations. Nonetheless, there will be shortages of ‘life’s fluid’ because, given increasing…

Photo

Symposium @ ECCMID 2019

How laboratories can help detect AMR and sepsis sooner

Beckman Coulter, a global leader in clinical diagnostics will be demonstrating its latest comprehensive solutions in microbiology, urinalysis and hematology at the 29th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). During the conference, Beckman Coulter is also hosting a symposium where attendees will learn how the laboratory can help physicians detect…

Photo

Rapid diagnostics

T2 Biosystems hosts integrated symposium at ECCMID 2019

T2 Biosystems, maker of rapid diagnostic technology to aid in the detection of blood stream infections to prevent sepsis, will host an integrated symposium titled “Rapid Diagnostics Direct from Whole Blood: A Solution for Fast and Appropriate Antimicrobial Therapy,” at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Monday, April 15, 16:00-18:00…

Photo

Meeting of the generations

We need a Senior Laboratory

It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results. Professor Kai Gutensohn, Managing Director and Medical Director of AescuLabor…

Photo

Lab equipment

Horiba launches D-Dimer hematology reagent

Horiba Medical announces the availability of a D-Dimer reagent for their semi-automated Hemostasis instruments. The D-Dimer is a key measurement and the reference exclusion test for the diagnosis of deep vein thrombosis or pulmonary embolism and may also be used for monitoring Disseminated Intravascular Coagulation. The new Yumizen D-Dimer reagent kit is available for Yumizen G hemostasis…

Photo

Getting personal(ised)

Pathology: Moving us towards precision medicine

The European Society of Pathology (ESP) holds its European Congress of Pathology (ECP) at different venues annually. This year, in Spain, 3,448 delegates from 87 countries attended. There, ESP president Dina Tiniakos spoke about the increasing role of pathology in precision medicine including challenges linked to digitisation. ‘Precision medicine is the centre-point for cancer management, but…

Photo

ß-D Glucan

New test for early fungal infection detection

At the National Reference Centre for Invasive Fungal Infections (Hans-Knöll Institute Jena) and the Institute for Hygiene and Microbiology, Würzburg University, Professor Oliver Kurzai and team utilise the fast and user-friendly β-D-Glucan Test, supplied by Fujifilm Wako Chemicals Europe GmbH, to check immunocompromised patients for signs of life-threatening, invasive fungal infections.…

Photo

Linked laboratories

New Dutch digital pathology advances

Efforts have been made to digitise pathology in the Netherlands, where the Dutch pathology network PALGA has run since 1990, connecting all of the Netherlands’ laboratories. Paul J van Diest, head of the pathology department at the Utrecht University Medical Centre, presented the brand new Dutch digital pathology platform during ECP 2018. Launched this year, this enables quicker, easier…

1021 show more articles