Laboratory/pathology

From clinical chemistry to digital pathology: Read more about how modern medical laboratories and procedures in pathology play a vital role in the detection and prevention of diseases and in medical research.

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Search for signatures

‘Long Covid’ biomarkers in blood could lead to diagnostic test

Markers in our blood – ‘fingerprints’ of infection – could help identify individuals who have been infected by SARS-CoV-2, the coronavirus that causes Covid-19, several months after infection…

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Covid-19 detection

New blood test measures immunity against SARS-CoV-2 and its variants

The Lausanne University Hospital (CHUV) and EPFL teamed up to develop a new test that’s sensitive enough to measure the amount of SARS-CoV-2 neutralizing antibodies present in the bloodstream. The…

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Prevention

Specimen diversion devices lower blood culture contamination

Blood cultures are among the most important laboratory tests a patient can have, especially to diagnose serious infections. Contamination is a constant concern – a patient could be misdiagnosed due to a false-positive test. Even with the most diligent quality control measures to limit contamination, including rigorous skin disinfection, contamination may occur from skin fragments colonised with bacteria that are dislodged with venipuncture. However, when initial specimen diversion (ISD) techniques are used, potential rates of contamination from skin fragments can drop to near zero.

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Automated image analysis

Algorithm detects biomarker in aggressive breast cancer

A researcher at the Technical University of Denmark (DTU) has developed a mathematical model for use in automated image analysis of tissue samples. The model provides the possibility for better and…

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Digital pathology

Today’s tissue for tomorrow’s research

Specialist biorepositories are helping advance personalised medicine by supporting the availability of human tissue for research using digital pathology techniques. The pivotal role of the Glasgow…

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Early detection of coronavirus presence

Covid-19 wastewater testing: new quantification kit launched

Life science research and clinical diagnostics company Bio-Rad Laboratories announced the launch of its PREvalence ddPCR SARS-CoV-2 Wastewater Quantification Kit, a tool to detect the virus that…

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Tissue dissection

World‘s first automated high throughput tissector launched

Molecular pathology company Xyall BV launches its Tissector High Throughput (HT) system for precision diagnostics. This is a world first – enabling high volume, molecular diagnostic laboratories to…

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Neoadjuvant chemotherapy

Breast cancer: New test predicts therapy success

In a collaboration with the Faculty of Statistics at TU Dortmund and the University Medical Center in Mainz, a research team at the Leibniz Research Centre for Working Environment and Human Factors…

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Sample-to-answer workflow

Partnership for Covid-19 test solution

SpeeDx Pty, Ltd. and MolGen announced the signing of an agreement to collaborate on supply and distribution of clinical diagnostics products and instrumentation across Europe and Asia Pacific. The…

Products from Labbook

Sarstedt – S-Monovette - Venous Blood Collection

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Mindray – BS-800M Clinical Chemisty Analyzer

Clinical Chemistry

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Mindray – BS-430 Clinical Chemistry Analyzer

Clinical Chemistry

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Analysis of 2nd and 3rd Corona wave

Rapid tests effectively contain Covid-19

Rapid tests effectively broke Covid-19 infection chains in spring 2021. This is shown by a model developed by researchers of the ECONtribute: Markets & Public Policy Cluster of Excellence of the Universities of Bonn and Cologne, the Collaborative Research Center Transregio 224 EPoS of the Universities of Bonn and Mannheim, and the Institute for the Study of Labor (IZA). According to the…

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Personalised medicine

'Body-on-a-chip' technology boosts drug development

Integrating laboratory functions on a microchip circuit is helping improve the cost-effectiveness of drug development. So-called ‘lab-on-a-chip’ or ‘human-on-a-chip’ technology can highlight which treatments may, or may not, work before advancing along the clinical trial process. It can also have benefits for chronic and rare diseases, as well as helping shape personalised medicine.…

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Antibiotic resistance

Five-minute MRSA detection with aptasensor swabs

An international research team from Saudi Arabia, Germany, and Jordan has developed a novel pathogen aptasensor swab designed to qualitatively detect, within five minutes, any methicillin-resistant Staphylococcus aureus (MRSA) contamination that remains in a hospital isolation room or other surface following standard decontamination and cleaning.

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Detecting Coronavirus

AI vs. Covid-19: ‘Barcode’ brings quicker test results

When patients are admitted to a hospital emergency room (ER) it is immediately vital to determine whether s/he has Covid-19. However, with a regular PCR test a result can take up to a few hours. Thus, initially, the patient must be isolated. During the height of the corona pandemic last year, researcher Ruben Deneer from Eindhoven University of Technology (TU/e) and clinical chemist Arjen-Kars…

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Customer Reference

And still it scans! 15 years of experience with Hamamatsu Photonics NanoZoomer

We recently had the pleasure of interviewing Dr. Peter Riegman from Erasmus University. Dr. Riegman is a Molecular Biologist and head of the Erasmus MC Tissue Bank. As an early adopter of digital pathology, Dr. Riegman purchased his first Hamamatsu Photonics whole slide scanner in 2005. It was a NanoZoomer HT, one of Hamamatsu’s very first production units, and it is still in daily use at…

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AI-assisted analysis

Prediciting viral infections with microscopy & deep learning

When viruses infect cells, changes in the cell nucleus occur, and these can be observed through fluorescence microscopy. Using fluoresence images from live cells, researchers at the University of Zurich have trained an artificial neural network to reliably recognize cells that are infected by adenoviruses or herpes viruses. The procedure also identifies severe acute infections at an early stage.

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Handheld rapid testing

New tech to diagnose infections in minutes - without a lab

The idea of visiting the doctor’s office with symptoms of an illness and leaving with a scientifically confirmed diagnosis is much closer to reality because of new technology developed by researchers at McMaster University. Engineering, biochemistry and medical researchers from across campus have combined their skills to create a hand-held rapid test for bacterial infections that can produce…

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Oncology early detection tool

Blood test for 50+ types of cancer promising for screening

Final results from a study of a blood test that can detect more than 50 types of cancer have shown that it is accurate enough to be rolled out as a multi-cancer screening test among people at higher risk of the disease, including patients aged 50 years or older, without symptoms. In a paper published in the cancer journal Annals of Oncology, researchers report that the test accurately detected…

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Coronavirus epidemiology

A cloud-based software for the surveillance of SARS-CoV-2 variants

In-vitro-diagnostics company bioMérieux has launched Episeq SARS-CoV-2, a genomic software solution to support microbiology labs in identification and reporting from raw sequencing data related to SARS-CoV-2 variants. Viral mutation is a naturally occurring phenomenon leading to the emergence of variants that can have different characteristics. Today, a number of SARS-CoV-2 variants are…

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Sepsis detection

T2 Biosystems to participate at clinical conferences in June and July 2021

T2 Biosystems, Inc. announced the its participation in three virtual conferences this summer. The company, which specialises in the rapid detection of sepsis-causing pathogens, will take part in the American Society for Microbiology’s (ASM) and Federation of European Microbiological Societies’ (FEMS) World Microbe Forum; Sepsis Alliance’s inaugural Sepsis Tech and Innovation 2021…

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Infertility

Beckman Coulter launches Access AMH Advanced

Beckman Coulter announced the launch of an AMH test that uses a validated cut-off to aid in the assessment of poor ovarian response. This new assay helps clinicians predict poor ovarian response in those who plan to undergo controlled ovarian stimulation as part of an in vitro fertilisation (IVF) protocol.

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Coronavirus disease biomarkers

New Covid-19 testing method gives results within one second

The Covid-19 pandemic made it clear technological innovations were urgently needed to detect, treat, and prevent the SARS-CoV-2 virus. A year and a half into this epidemic, waves of successive outbreaks and the dire need for new medical solutions — especially testing — continue to exist. In the Journal of Vacuum Science & Technology B, researchers from the University of Florida and…

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Coronavirus diagnostics

Rapid Covid-19 test delivers results within 4 minutes with 90 percent accuracy

A low-cost, rapid diagnostic test for Covid-19 developed by Penn Medicine provides Covid-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0). Compared to existing methods for Covid-19 detection, RAPID is inexpensive and…

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dPCR and HSAFM

Low-cost technique for missed genetic mutations

A new low-cost method targeting genetic mutations often missed by existing diagnostic approaches has been developed. Researchers at Virginia Commonwealth University (VCU) in the United States noted that most rearrangement mutations implicated in cancer and neurological diseases fall between what can be detected by DNA sequence reads and optical microscopy methods. The new technique combines…

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Labs processing 2,000 to 5,000 tests a day

Workflow automation solutions for mid-volume laboratories

Clinical diagnostics company Beckman Coulter announced the European launch of the DxA 5000 Fit, a workflow-automation solution designed to fit into medium-sized labs that run fewer than 5,000 tests a day. The clinical laboratory has gone through trial by fire in 2020, where total testing was 245% of baseline volumes, with ~55% being SARS-CoV-2 molecular tests. Despite vaccines, many industry…

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Products of the Month

Enhance your Microscopy Workflow

Did you know that changing microscopy camera can make a real difference to your microscopy workflow? Packed full of smart features to make your imaging faster and easier, Olympus’ new DP23 and DP28 (4K) cameras enable streamlined, comfortable sample analyses at the monitor and easier, smoother conferencing. Get the most out of the monitor view and discover the many benefits of the DP23 and DP28…

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Tau pathology in the brain

Defining the 4 subtypes of Alzheimer's

Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in Nature Medicine.

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Precise, affordable, and portable

A health testing platform that consolidates multimodal and multiplex testing to one device

Fluxergy envisions that a fully articulated democratized testing health system has the potential to reduce the likelihood and the ultimate severity of pandemics like Covid-19. Our mission is to unlock the true potential of diagnostics to play a far greater and more important role in the early detection of diseases and ongoing monitoring of health status, where and when it matters most: at the…

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Coronavirus research

'Covid-19 atlas' uncovers differing immune responses in asymptomatic versus severe cases

The largest study of its kind in the UK has identified differences in the immune response to Covid-19 between people with no symptoms, compared to those suffering a more serious reaction to the virus. The research by Newcastle University and collaborators within the Human Cell Atlas initiative found raised levels of specific immune cells in asymptomatic people. They also showed people with more…

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After overcoming a Corona infection

Covid-19: Study on long-term antibody protection

Does overcoming a SARS-CoV-2 infection protect against reinfection? The “Rhineland Study”, a population-based study conducted by DZNE in the Bonn area, is now providing new findings in this regard. Blood samples taken last year indicate that an important component of immunity – the levels of specific neutralizing antibodies against the coronavirus - had dropped in most of the study…

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POC Troponin I analysis

Expediting the diagnosis of heart attack

Siemens Healthineers announced the company's Atellica VTLi Patient-Side Immunoassay Analyzer has obtained CE mark and is expected to be available later this spring. The Atellica VTLi analyzer provides lab standard, high-sensitivity cardiac troponin I (hs-cTnI) test results to clinicians in eight minutes using a patient's fingerstick blood sample. With this industry first technology, Siemens…

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