Cancer

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Focused ultrasound

Histotripsy: fighting tumors with microbubbles

Focused ultrasound waves create microbubbles in a fluid – a phenomenon called cavitation. In a current study, this process is used to destroy liver tumors and metastases. In this…

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Cancer research

How to break through a tumor's protective shield

The immune system protects the body from cancer. To protect healthy body cells from its own immune system, they have developed a protective shield: the protein CD47 is a so called "don’t eat…

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Mass spectrometry goes handheld

A pen to pin down the fringes of cancer

Mass spectrometry – a powerful tool for analysing the molecular composition of a tissue sample – is invaluable during cancer surgery. However, mass spectrometers are complex and unwieldy, and…

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Ductal adenocarcinoma

Pancreatic cancer ‘priming’ may make chemotherapy more effective

A new approach to ‘prime’ the tumour environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer. In…

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Promising approach

New nanoparticles suppress resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to an immunotherapy treatment for cancer. The approach, proven in mice…

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Enhancing T cell response

New targets for cancer vaccines identified

Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body’s own immune system to destroy…

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DNA damage causes AML

Cancer chemotherapy side-effects on blood cell development

By analysing secondary acute myeloid leukaemias, researchers at the Institute for Research in Biomedicine (IRB) Barcelona have detected mutations caused by platinum-based chemotherapies in cells that were healthy at the time of treatment. Treatment with chemotherapies influences the development of blood cells, favouring clonal hematopoiesis from cells with pre-existing mutations. The study has…

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Combined chemotherapy

Pancreatic cancer: New treatment promising for older patients

Pancreatic cancer is a disease of the elderly: the average age of patients is 72. In Austria, about 1,600 people are diagnosed each year. Since pancreatic cancer has no specific symptoms, it is not usually diagnosed until the tumor is locally advanced or has already metastasized. Once the tumor has metastasized, it is usually no longer treatable by surgery or radiotherapy. In addition, the drug…

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Patient response testing

New method predicts which cancer therapies work (and which don't)

A new technology that can study which therapies will work on patients with solid cancerous tumours has been developed by scientists at University College London (UCL). Researchers say the tool, which can rapidly test tumorous tissue against different treatments, such as chemotherapy, immunotherapy or radiotherapy, could be used by clinicians to pinpoint the best therapy for a particular patient.

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Understanding oncogenesis

How normal cells turn into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients. Previous studies have achieved this only by using powerful viral factors that are not common in human cancers. Since many human cancer types still lack specific diagnostic…

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Precision oncology

Personalized health and genomics: Minimizing collateral damage

A solid diagnosis has always been the first step on any patient’s journey to health. However, diagnostic categories are necessarily oversimplifications. In the last decades, medical professionals and scientists have begun to uncover the true variability in patients’ physiological and biochemical make-up that is the principal cause for individual variations in the way diseases present…

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Patient empowerment

Should cancer patients participate in tumour conferences?

The goal of tumour conferences is to determine the best treatment for patients with complex cancers. In these interdisciplinary meetings, doctors from various branches of medicine including oncology, radiology, surgery and pathology convene to talk about a patient's case – however, the patient is rarely present. So far, only a few breast cancer and gynaecological centres in Germany offer their…

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Brain cancer research

Researchers 3D-print entire active tumor

Researchers at Tel Aviv University have 3D-printed a first-of-its-kind glioblastoma tumor that mimics a living cancer malignancy, powering new methods to improve treatment and accelerate the development of new drugs for the most lethal type of brain cancer. Glioblastoma is notoriously fatal as it accounts for the majority of brain tumors and is highly aggressive. The average survival time of…

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Omics in cancer care

Personalizing laboratory medicine

To avoid adverse reactions, personalised laboratory medicine can help to predict a patient’s drug response. Investigations based on DNA and other omics technologies – e.g. genomics, transcriptomics, proteomics, metabolomics – along with microarray technologies, is making a particularly valuable contribution to cancer care, in which personalised approaches are becoming possible through…

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Tumor environment

When cancer cells turn acidic to survive

For the first time, researchers at the Norwegian University of Science and Technology (NTNU) have shown how cancer cells reprogram themselves to produce lactic acid and to tolerate the acidic environment that exists around tumors. The finding could lead to a whole new direction for treating cancer. The breakthrough is the result of more than 13 years of work. The next step in research could…

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Increased processing power

Personalizing cancer treatment with quantum computing

Cancer patients’ medical records can often comprise up to 100 terabytes of individual — and usually very heterogeneous — data, including blood and tumor values, personal indicators, sequencing and treatment data, and much more besides. Up to now, it has been virtually impossible to use this wealth of information efficiently due to a lack of appropriate processing mechanisms. As a result,…

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Cell delivery vehicles

Bio-inspired nanocontainers could enter cells and release their medical cargo

Nanocontainers can transport substances into cells where they can then take effect. This is the method used in, for example, the mRNA vaccines currently being employed against Covid-19 as well as certain cancer drugs. In research, similar transporters can also be used to deliver labelled substances into cells in order to study basic cellular functions. To take advantage of their full potential,…

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Identificación de mutaciones tumorales

El aprendizaje automático impulsa la medicina personalizada del cáncer

El laboratorio de Genómica Biomédica del IRB Barcelona (Institute for Research in Biomedicine) ha desarrollado un método computacional que identifica las mutaciones causantes del cáncer para cada tipo de tumor. Este y otros desarrollos del mismo laboratorio buscan acelerar la investigación oncológica y ofrecer herramientas para que los oncólogos puedan elegir el mejor tratamiento para cada…

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Tool to identify tumour mutations

Machine learning fuels personalised cancer medicine

The Biomedical Genomics laboratory at the Institute for Research in Biomedicine (IRB) Barcelona has developed a computational tool that identifies cancer driver mutations for each tumour type. This and other developments produced by the same lab seek to accelerate cancer research and provide tools to help oncologists choose the best treatment for each patient. The study has been published in the…

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Software solution

Using AI to match cancer patients to early phase clinical trials

Cancer informatics and digital pathology provider Inspirata announced that King’s Health Partners ECMC and Guy’s and St Thomas’ NHS Foundation Trust will pilot its Trial Navigator software as part of an evaluation the organisations are conducting into how artificial intelligence based automation can improve the identification and efficiency of matching patients with cancer to early phase…

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Cancer care

Remote 24-hour monitoring shows promise in chemotherapy patients

Remote 24-hour monitoring for cancer patients receiving chemotherapy helps to better manage side effects and improve quality of life, finds a study published by The BMJ. The researchers say remote monitoring can provide a safe, secure, and “real time” system that optimises symptom management and supports patients to remain at home - and is particularly relevant in the context of the Covid-19…

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Health economics

Why certified cancer centers are worth the extra input

Quality assurance in cancer medicine has a reputation for being expensive and involving considerable outlay. For the first time, a cost-effectiveness analysis has now shown that patients treated in certified cancer centers not only survived longer than patients in non-certified hospitals, but also cost less, despite the greater resource commitment required. This was established by health…

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