Surviving without lungs for 48 hours: Surgeons describe how they removed a patient’s infected lungs and built “artificial lungs” to keep him alive until a double lung transplant was available.
Cardiac imaging is evolving, and new techniques continue to uncover the secrets of the heart for cardiologists who know how to use them. At the ESC 2025 Congress in Madrid, four experts explored cutting-edge developments across different modalities. Ranging from AI-assisted ultrasound image acquisition and accelerated MRI protocols to advanced prognostic tools for CT and nuclear imaging, these…
Gadolinium-based contrast agents enhance visibility but also pose a significant health risk. A new AI-powered virtual MRI imaging technique is designed to offer a safer diagnostic approach.
CT imaging is important to detect residual lung abnormalities after a Covid-19 infection. To avoid confusion with interstitial lung diseases, experts from 14 countries published a best-practice guide.
Using cardiac MRI, researchers have found that long-term exposure to air pollution is associated with early signs of heart damage, according to a new study.
Analyzing heart imaging and a full spectrum of medical records, a new AI tool can reveal previously hidden information about a patient’s heart health, including predictions of sudden cardiac arrest.
A new PET imaging technique can accurately detect and monitor Mycobacteroides abscessus lung infections—one of the most difficult-to-diagnose conditions in patients with lung diseases.
Researchers have developed an AI tool that creates synthetic yet medically accurate models of fibrotic heart tissue (heart scarring), aiding treatment planning for atrial fibrillation (AF) patients.
Nuclear medicine specialists have successfully used the radiopharmaceutical Ga-68-Trivehexin from Trimt to accurately diagnose patients with pulmonary fibrosis and concurrent lung cancer.
The shimmering blue wings of a Morpho butterfly are not just beautiful to look at - they can also help make cancer diagnosis faster, more accurate and more accessible, new research finds.
Mindray, one of the world's leading developers and providers of advanced medical imaging devices and solutions, launched Resona A20, a premium ultrasound system, at EUROSON 2024 in Naples, Italy.
PET/CT image analysis using artificial intelligence (AI) can predict the occurrence of interstitial lung disease, a serious side effect of immunotherapy in lung cancer, a new study shows.
Hyperbaric oxygen therapy (HBOT) treatments could offer relief to breast cancer patients who experience late toxicities following radiotherapy treatment. To date, the handful of completed clinical trials only produced inconclusive or contradictory results. Therefore, results from the latest trial, named HONEY (Effect of Hyperbaric Oxygen Therapy on Breast Cancer Patients with Late Radiation…
A new discovery about how the liver flushes cholesterol from the body could lead to more effective treatments for cardiovascular disease – the leading cause of death worldwide.
A new study confirms fibrosis as a prognostic indicator in HER2-negative, the most common breast cancer, and opens the way to antifibrotic drug treatments.
A new type of magnetically controlled prosthetic hand allows amputees to reproduce all movements simply by thinking and to control the force applied when grasping fragile objects.
Researchers have identified fibrotic scarring as a key source of resurgence of glioblastoma multiforme (GBM). The new insights could lead to better prevention of this type of brain cancer.
Systemic lupus erythematodes can lead to severe kidney damage. However, until now, the cause for this remained unclear. New research has now revealed the underlying mechanism.
Enter symptoms into ChatGPT, receive an accurate diagnosis? Research reveals that LLM AI models are not quite there yet, struggling to identify genetic conditions from patient-written descriptions.
Using conventional ultrasound, researchers have developed a model that determines whether conditions such as fibrosis or edema are present in the lungs, and gives information about the severity.
Researchers have created a mucus-based bioink which can be used for 3D printing lung tissue. This advance could one day help study and treat chronic lung conditions.
Diagnosis and monitoring medical conditions, including cancer, diabetes, heart disease, and infections: In this opinion article, Alix Joseph (Linxens) explores the potential of sweat analysis.
Using an advanced scanner, researchers have developed a technology that can detect the earliest changes in the kidney when scar tissue begins to form.
How do pathogenic bacteria evolve to become epidemic? To find out, researchers examined DNA data from almost 10,000 samples taken from infected individuals, animals, and environments around the world.
Researchers present a new method for generating human alveolar epithelial type I cells. This could ultimately progress therapies for people living with pulmonary diseases.
Cancer patients receiving radiotherapy run the risk of injuring their lungs. This can lead to conditions like pneumonitis and fibrosis. A new cell-by-cell model can help make treatments safer.
Researchers have identified how cells work to resolve "frozen shoulder", a painful and disabling condition affecting the ligaments that form the shoulder joint capsule.
Research reveals how a new mechanism could improve the efficiency of current treatments for diabetes. This may open up new ways of approaching metabolic diseases that are a global health problem.
An interplanetary title for a quite down-to-earth topic: The symposium "Men are from Mars, women are from Venus" at the EACVI congress (European Association of Cardiovascular imaging) launched into the differences between the hearts of men and women. While the speakers could firmly establish that both sexes share the same home world, variations in their cardiac anatomy warrant a more…
A research team has developed a nanoparticle-based contrast agent with the properties necessary to successfully use MRI for targeted diagnosis of liver fibrosis.
A new synthetic antibiotic developed by University of Liverpool researchers is shown to be more effective than established drugs against ‘superbugs’ such as MRSA, a new study shows.
AI features for automation, integrated systems and more: the role of medical technology has never been as vital as today, and MedTech companies from Taiwan are putting their best foot forward to contribute. At the 2023 Medica trade fair, visitors of the Taiwanese pavilion not only had the opportunity to see the latest medical products on display, but also get acquainted with Taiwanese culture in…
Engineers from MIT are developing a device containing insulin-producing cells and a tiny oxygen-producing factory to keep the cells of diabetes patients healthy.
A new research breakthrough could lead to the development of new treatments for people with compromised immune systems, such as those with cystic fibrosis.
Omar Darwish, PhD student at King's College London, is researching new approaches to 3D MRE sequences for measuring liver fibrosis and inflammation simultaneously in obese patients.
At ECR in Vienna, Carestream presented the latest additions to their product portfolio, and gave insights into their commitment to tackling a devastating lung disease.
Carestream Health is funding and participating in an innovative pilot with OSIC that could lead to radiographs providing an early window into manifestations of IPF that are currently undetected.
Researchers have developed an inhalable powder that could protect lungs and airways from invasion from the coronavirus or flu viruses by reinforcing the body’s own mucosal layer.
In a world first, scientists from Singapore and Germany have shown that regenerative therapy to restore impaired kidney function may soon be a possibility.
A promising new application for photon-counting CT: The new technology outperforms conventional CT in detecting subtle damage in the lungs of patients with persistent symptoms of Covid-19.
Multiparametric ultrasound will play an increasing role in imaging investigation and diagnosis as more subspecialities reap the benefits from the modality, Professor Paul Sidhu believes. The leading expert predicts that it will be more cost-effective and comfortable for patients and take point-of-care-testing onto a new level by embracing other parameters in the imaging process.
Endosonography poses unique challenges for medical professionals, because two demanding disciplines have to be mastered at the same time. The use of artificial intelligence (AI) could help speed up the notoriously slow learning curve of the procedure, says Prof Dr Christoph F. Dietrich. At the Visceral Medicine Congress in Hamburg, the expert explained how AI can help endosonography achieve…
A new X-ray technology has been used to identify a link between the damage that severe Covid-19 can inflict on lungs and pulmonary fibrosis, a disease that causes severe scarring of lung tissue.
To assess diffuse liver disease, MRI is currently the modality of choice. New developments in artificial intelligence (AI) could tip the scales in favour of CT imaging. At ECR 2022 in July, experts showed how AI technology enables CT to quantify liver fat as exquisitely as MRI.
Despite treatment, chronic lung diseases such as COPD or cystic fibrosis can become so severe that a lung transplant is necessary. Dr Urte Sommerwerck explains which patients might be considered for transplantation and why follow-up is as important as the surgery itself.
Recent advances in CT have focused mainly on software, yet new technology could push the modality much further, experts showed at ECR 2022.
Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.
Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports.
Researchers developed an AI that accurately and quickly diagnoses idiopathic pulmonary fibrosis, based only on information from lung images and medical information collected during daily medical care.
Patients with multiple architectural distortion (AD) identified on digital breast tomosynthesis may benefit from biopsy of all areas, given the variation of pathologic diagnoses across individuals.
Physicians use AI-powered technology for faster and earlier detection of diseases. At ECR Overture, Dr Steven Schalekamp, PhD, discussed the application of AI for chest radiography in paediatrics.
Scientists have identified a new disease in a ground-breaking discovery that could help patients with unexplained liver and kidney problems.
Scientists at the La Jolla Institute for Immunology discover new drug target for severe asthma and fibrosis.
An international research team has now found an approach to lower the activation of hepatic stellate cells (HSCs) and reduce the associated development of liver fibrosis.
A new study offers hope against liver cancer: A vaccine proved to be safe and effective protection in premalignant and malignant liver diseases in preclinical mouse models.
Hyaluronic Acid LT Assay is an in vitro diagnostic test (IVD) for the quantitative determination of hyaluronic acid based on the latex agglutination method. This turbidimetric method can be applied to general clinical chemistry analyzers.
Researchers have developed a smartwatch that assesses cortisol levels found in sweat. The device opens new possibilities for personal health monitoring.
RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based compounds is far from being fully tapped, as RNA allows for entirely new therapeutic approaches.
A tiny ‘pop-up’ sensor monitors the electrical activity inside heart cells. The device could provide new insights into cardiac diseases, including myocardial infarction and arrhythmias.
The Coronavirus SARS-CoV-2 infects the kidneys and contributes to tissue scarring, as shown by researchers from Germany and the Netherlands.
To counteract the spread of resistant germs, researchers have developed new drug candidates that are able to render one of the most important hospital germs harmless.
Even as we battle one pandemic (Covid-19), we sit on the cusp of another. Europe has one of the highest burdens of chronic liver disease (CLD) in the world, driven largely by alcohol overconsumption, viral hepatitis, and obesity. Furthermore, non-alcoholic fatty liver disease (NAFLD) is increasingly common and is a significant contributor to CLD – especially in people with diabetes, where its…
Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.
Autoimmune hepatitis (AIH) is a chronic liver inflammation that is triggered by an immunological malfunction. In this case, the immune system falsely recognises the patient's own liver cells as "foreign to the body". The symptoms of this rare liver disease are unspecific, and the exact cause is not yet known. If left untreated, AIH can lead to abnormal scarring (fibrosis) of the liver,…
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
Molecular imaging, guided by novel tracers, is emerging as an important diagnostic and therapeutic tool in cardiovascular medicine. Delegates at ICNC-CT, the online International Conference on Nuclear Cardiology and Cardiac CT, also heard that cardiology can learn from fields such as oncology and neurology that have already made important advances in this area. Professor Frank Bengel, who is…
Women are missing out on appropriate cardiac care because guidelines and medications often fail to take into account gender and conditions that specifically affect the female population. Women are also underrepresented in clinical trials for new cardiac therapies.
Research has identified critical factors that enable dangerous bacteria to spread disease by surviving on surfaces in hospitals and kitchens. The study into the mechanisms which enable the opportunistic human pathogen Pseudomonas aeruginosa to survive on surfaces, could lead to new ways of targeting harmful bacteria. To survive outside their host, pathogenic bacteria must withstand various…
Magnetic resonance imaging (MRI) is widely used to identify the narrowing or blockage of blood vessels. Contrast agents improve the visibility of the structures and offer more accurate information of vascular conditions such as vascular blockage and stenosis. Commonly used gadolinium-based contrast agents must be administered in chelated forms due to the gadolinium ions' high toxicity and pose…
The management of biopsied breast lesions that are diagnosed as abnormal but are not definitively malignant is challenging and controversial. Treatment ranges from diligent follow-up, with imaging and subsequent biopsy, to surgical excision. Researchers at the Medical University of Vienna (Medizinische Universität Wien), Austria, have developed and validated a software algorithm designed to…
Covid-19 causes characteristic changes in lung tissue visible in CT scans and chest radiographs, known as “ground-glass” opacities. Imaging is now considered a valid alternative, possibly even superior to RT-PCR. ‘This sparked an international debate about the role of CT in the diagnostic work-up of Covid-19,’ said radiologist Professor Cornelia Schäfer-Prokop.
Rather than using techniques separately, researchers have determined that coupling image-based and serum-based biomarkers achieves a higher diagnostic accuracy in detecting stage two liver fibrosis, or above. The study team, from the NAFLD Research Center, University of California at San Diego (UCSD), and colleagues at Yokohama City University in Japan, used magnetic resonance elastography (MRE)…
Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.
An up-and-coming gene therapy for blood disorders. A new class of medications for cystic fibrosis. Increased access to telemedicine. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of clinicians and researchers from Cleveland Clinic. In conjunction with the 2020 Medical Innovation Summit, Cleveland Clinic…
Artificial Intelligence (AI) has, for the first time, measured blood flow to the heart to help predict which patients may suffer myocardial infarction or stroke. A research team at University College London and Barts Health NHS Trust and the National Institutes for Health (NIH) in the USA – are optimistic that AI analysis of perfusion maps will be a reliable, convenient and detailed new…
In the most comprehensive study of COVID-19 pediatric patients to date, Massachusetts General Hospital (MGH) and Mass General Hospital for Children (MGHfC) researchers provide critical data showing that children play a larger role in the community spread of COVID-19 than previously thought. In a study of 192 children ages 0-22, 49 children tested positive for SARS-CoV-2, and an additional 18…
Manganese and iron oxide contrast agents can replace gadolinium-based contrast agents (GBCA) in a number of MRI examinations, but gadolinium remains a strong candidate when properly indicated, especially with AI-driven dose reduction and advances to increase relaxivity, a French expert explained at ECR 2020. GBCA have been MRI companions for many years. In France, 30% of all MR examinations are…
There are major complications from COVID-19 – ARDS, pulmonary embolism and neurological – that imaging can help detect, manage and/or follow up in the long term, radiologists from France and the UK explained during a recent ESR Connect session. ARDS is the most dreaded complication and the number one morbidity in COVID-19 patients. The incidence was up to 30% of patients in initial reports.…
The coronavirus pandemic created unprecedented upheaval and challenges within health systems, economies, and society. In hospitals, new ways of working had to evolve. Social distancing led to virtual consultations and teleradiology has found an added dimension. We asked three radiologists about the relevance of teleradiology during the epidemic, and what the future holds.
Artificial Intelligence is an essential tool for the healthcare operators on the front line in the fight against the Coronavirus pandemic. ASST Vimercate Hospital chose and implemented in the midst of the COVID-19 emergency REiLI, Fujifilm Medical Systems’ Artificial Intelligence.
It’s currently difficult to screen for certain liver diseases and to monitor these conditions once they’re discovered. A team led by investigators at Massachusetts General Hospital (MGH) and the Massachusetts Institute of Technology (MIT) recently developed a non-invasive imaging method that has promising clinical potential to accomplish both goals. The technique is described in a study…
Niels-Bjarne Woods, a researcher at Lund University in Sweden, has developed lung-specific mesenchymal stem cells to treat inflammation of the lungs and fibrosis. This research now may be the needed breakthrough for treatment of the severe respiratory issues related to COVID-19. A clinical study may soon be underway contingent on a successful application to the Swedish Medical Products Agency.…
The Central Laboratory at the Medical University Hanover, Germany, is prepared to handle virtually any clinical chemistry task, from a routine test to the most complex analysis. Equipped with state-of-the-art technology and thanks to a high degree of automation, the team can process more than 3,000 specimens, mostly blood and urine, in a single day. Professor Ralf Lichtinghagen, European…
As coronavirus disease COVID-19 continues to jet and alight invisibly around the globe, scientists now report that the virus has mutated to become two strains: the older ‘S-type’ appears milder and less infectious, while the later-emerging ‘L-type’, is more aggressive, spreads more quickly, and currently accounts for about 70 per cent of cases. Worldwide, medical researchers are exploring…
A new method to detect cancer in its early stages using a targeted MRI contrast agent that binds to proteins has been identified by a team of researchers led by Georgia State University Regents’ Professor Jenny Yang. In their study, published in the journal Science Advances, Yang and her colleagues at Georgia State and Emory University describe a newly identified biomarker for detection of…
Antibiotic-resistant pathogens pose one of the greatest threats to public health worldwide. In the near future, harmless bacterial infections may no longer be treatable and may again become the most common non-natural cause of death. At the same time, the available repertoire of antibacterial agents is becoming increasingly smaller as resistance rates rise.
A smart shirt, developed by Canadian startup Hexoskin, has been successfully tested as a potential diagnostic modality for chronic obstructive pulmonary disease (COPD) at the Radboud University Medical Centre in The Netherlands. “COPD is a growing problem with around 64 million people suffering with the condition worldwide. When patients suffer an increase in their symptoms, such as coughing…
Unlike other surgical specialties, ear nose and throat (ENT) has been poorly served by the introduction of robotic platforms to enhance procedures. Since the da Vinci system first gained FDA approval in 2000, robot-assisted surgery has become commonplace in many specialties, including neurology, urology, etc. with numerous other general surgical applications. However, existing systems including…
Fatty liver disease is contributing to an increase in liver cancer and basic scientists at The University of Texas Health Science at Houston (UTHealth) have new insight as to why. In the journal Cancer Research, the investigators report that in mouse models, excess fat impairs the ability of a tumor-suppressing protein named HNF4α to do its job. “This study provides potential mechanisms for…
In adolescent and adult patients with cystic fibrosis (CF) taking lumacaftor-ivacaftor (Orkambi), the combination drug appears to improve lung function and body weight and reduce the need for intravenous antibiotic treatment, according to a French study published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. However, the treatment also…
The Queen Mary University of London team applied an artificial intelligence (AI) technique to analyse the heart MRI images of 17,000 healthy UK Biobank volunteers. They found that genetic factors accounted for 22-39 per cent of variation in the size and function of the heart’s left ventricle, the organ’s main pumping chamber. Enlargement and reduced pumping function of the left ventricle can…
The U.S. Food and Drug Administration approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. It is the first FDA-approved treatment for this rare lung condition. “Patients suffering from scleroderma need effective therapies, and the FDA supports the efforts…
Cardiovascular magnetic resonance (CMR) imaging has become faster, simpler and more widely available in recent years because it has evolved to deliver effective assessment and diagnosis of a range of heart conditions with expanding guideline indications.
A pioneering European research project designed to develop new diagnostic tests to assess patients with Non-Alcoholic Fatty Liver Disease (NAFLD) has expanded giving access to more patients. Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) funded by the European Innovative Medicines Initiative 2 Joint undertaking, brings together clinical scientists from international…
Pathologic-radiologic correlation is already utilised in various settings as a tool to assess the interpretive performance of imaging studies and identify radiologic features corresponding to histologic findings. However, correlative assessment is currently limited mainly to the fields of research and quality assurance, and is generally not a routine element of the radiologist or pathologist…
Analytically sensitive and specific detection of pharmaceuticals or metabolites in bodily fluids, as well as fast and reliable detection of human pathogens, are major challenges for instrument-based analytics in medical diagnostics. Over the past few years the combination of surface-enhanced Raman spectroscopy (SERS) and microfluidic devices (Lab-on-a-Chip) has emerged as a perfectly suited…
The traditional classification of diabetes, mainly in type 1 and type 2 diabetes, has been challenged by studies from Scandinavia. In the current issue of The Lancet Diabetes & Endocrinology, researchers from DDZ together with colleagues from DZD and University of Lund published a cluster analysis of diabetes allowing for phenotyping into subgroups, which extended the findings by showing that…
SuperSonic Imagine announces that a multicenter retrospective study conducted in Europe and China, has confirmed the clinical utility of ShearWave Elastography in patients with chronic liver disease, the first results of which were presented at the International Liver Congress (ILC 2019). The objective of this study was to evaluate the diagnostic value of ShearWave Elastography (SWE) in the…
The migrant population is fast growing and heterogeneous. Experts at a session held during the European Congress of Radiology (ECR 2019) concluded that radiologists can play a key role in detecting and differentiating related diseases. Migration is a growing phenomenon and has an impact on health, according to Jozef Bartovic from the World Health Organisation (WHO) in Copenhagen, Denmark.…
The speed of the human brain is remarkable. Almost immediately upon being exposed to stimuli, neurons are activated, prompting subconscious reactions and, a fraction of a second later, thought. But the speed at which we can noninvasively follow brain function using an MRI is not as impressive. Functional MRI (fMRI), which measures changes in blood-oxygen levels, has revolutionized neuroscience by…
Beckman Coulter, a global leader in clinical diagnostics will be demonstrating its latest comprehensive solutions in microbiology, urinalysis and hematology at the 29th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). During the conference, Beckman Coulter is also hosting a symposium where attendees will learn how the laboratory can help physicians detect…
Babies born with congenital hyperinsulinism (CHI) are at risk of suffering from permanent brain damage and life-long disability. Yet some will go on to suffer more severely than others as a result of their disease profile, report the researchers in an article published in Frontiers in Endocrinology. The research team have found that it is possible to predict when and how the disease may affect…
A protein associated with cancer growth appears to drive the deadly lung disease known as idiopathic pulmonary fibrosis (IPF), according to new research from Cedars-Sinai. The discovery, made in laboratory mice and human tissue samples, may have implications for treating the disease using existing anti-cancer therapies that inhibit the protein PD-L1. Idiopathic pulmonary fibrosis is a chronic,…
Researchers at Queen’s University Belfast have discovered a novel experimental treatment for chronic lung diseases that could improve the lives for people with Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary Disease (COPD).
Artificial intelligence (AI) continues to drive radiologists’ discussions. Among them, Associate Professor Georg Langs, head of the Computational Imaging Research Lab (CIR) at the University Clinic for Radiology and Nuclear Medicine at the Medical University of Vienna, believes: ‘The evaluation of patterns in data from imaging examinations and clinical information about patients using machine…
A study provides new insight into how the stiffening of breast tissue plays a role in breast cancer development. By examining how mammary cells respond in a stiffness-changing hydrogel, bioengineers at the University of California San Diego discovered that several pathways work together to promote the transformation of breast cells into cancer cells. The work could inspire new approaches to…
Nanoparticles can be found in processed food (e.g. food additives), consumer products (e.g. sunscreen) and even in medicine. While these tiny particles could have large untapped potential and novel new applications, they may have unintended and harmful side effects, according to a recent study by researchers from the National University of Singapore (NUS). Specifically, NUS researchers found that…
A clinical-scientific team specializing in head-and-neck cancer has identified a way to manipulate metabolism to potentially curb skin fibrosis – a common side effect of radiotherapy affecting quality of life of cancer survivors. The study findings from the laboratory of principal investigator Dr. Fei-Fei Liu, Chief, Radiation Oncology, Princess Margaret Cancer Centre, University Health…
Mariette Barbier, an assistant professor in the West Virginia University School of Medicine, and her research team are investigating ways to keep cystic fibrosis patients and other at-risk populations—including patients hospitalized for severe burns or recovering from major surgery—from catching this deadly illness.
Nanomedicine will play an increasingly important role in future diagnosis and treatment of cardiovascular disease, a subject explored in detail by four expert speakers at the British Cardiovascular Society conference in Manchester in June. The conference heard that the technology – dealing with dimensions and tolerances of less than 100 nanometres, especially the manipulation of individual…
A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK), a digestive hormone. In addition, blocking CCK may help prevent the spread of pancreatic tumors to other areas of the body (metastases). The new findings are published ahead of print in the American Journal of Physiology—Gastrointestinal…
Researchers at the University of Arizona College of Medicine – Phoenix are cross-utilizing plant biology, medicine and engineering to create a novel platform. They have developed a revolutionary "lung on a leaf" to study pulmonary diseases.
Idiopathic pulmonary fibrosis (IPF) is one of the most challenging and frustrating diseases that pulmonologists face. And despite affecting 1 out of 200 adults over the age of 65 in the United States, general awareness of IPF is low. “There’s a tremendous disconnect between the human impact of this disease and its recognition by the public. Few people have ever heard of it,” says Marc…
Schistosomiasis, a disease that is common in sub-Saharan Africa, is particularly widespread in Madagascar. The Schistosoma mansoni parasite responsible for the disease is linked to fibrotic changes in the liver which can be detected using point-of-care ultrasound.
Scientists used an experimental targeted molecular therapy to block a matrix-forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure. Researchers at the Cincinnati Children’s Heart Institute report in the journal Circulation testing a manufactured peptide called pUR4 to block the fibronectin protein in human…
Gadolinium-containing/gadolinium-based contrast agents (GCCAs/GBCAs) and their usage was a major topic at ECR 2018. Fuelled by the current debate a number of presentations focused on possible impact, risks and necessities. Some were highly specific, others took a broader view. The only consensus, however, seems to be the need for more research and the focus on safety. Three ECR speakers, Joseph…
Radiologists must ensure precise scientific data and radiology-based evidence are used to regulate the use of Gadolinium Containing Contrast Agents (GCCAs), a Spanish leading radiologist explained in closed-door leadership meeting earlier this year in Barcelona.
By no means are only elderly people at risk from heart diseases. Physically active individuals can also be affected, for example if a seemingly harmless flu bug spreads to the heart muscle. Should this remain undetected and if, for example, a builder continues with his strenuous job or an athlete carries on training, this can lead to chronic inflammation and in the worst case even to sudden…
Professor Dr Thomas Kröncke, Medical Director of Diagnostic and Interventional Radiology at Klinikum Augsburg, has been dealing with liver diseases for 17 years. Talking to European Hospital he explains which diseases the liver tends to mask and why fatty liver has become a public health issue.
A practicing radiologist specialising in ultrasound, Pavlos Zoumpoulis MD PhD is also President and CEO of Diagnostic Echotomography, a day clinic based in Kifissia, Greece. The past President of the Hellenic Society of Ultrasound in Medicine and Biology spoke with our European Hospital team about his experiences with the next-generation in shear wave elastography on Mindray’s Resona 7 platform.
A controversy regarding the benefit of early screening programmes for breast cancer continues. Germany, Austria and Switzerland have developed individual strategies. European Hospital asked three experts from these countries to outline each chosen system. Markus Hahn MD, senior consultant at the University Breast Centre in Tübingen, Martin Daniaux, MD, Head of Breast Diagnostics at the Breast…
Early research results suggest scientists might be on to a way to preserve heart function after heart attacks or for people with inherited heart defects called congenital cardiomyopathies. Researchers at the Cincinnati Children’s Heart Institute report in Nature Communications that after simulating heart injury in laboratory mouse models, they stopped or slowed cardiac fibrosis, organ…
Chronic lung infections caused by the bacterium Pseudomonas aeruginosa require complex and, in most cases, long-term treatment with antibiotics—new medication is badly needed.
Researchers at Case Western Reserve University School of Medicine have developed a method that could make magnetic resonance imaging—MRI—multicolor.
Obsolescence and strategies to manage equipment data to benefit patients were at the centre of debates during the Radiology Triangle meeting in Madrid earlier this year.
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent liver diseases worldwide and an estimated 20 million people in Germany are affected.
The association of biofilms with multi-drug resistance has highlighted the need for further understanding of biofilms and for anti-biofilm strategies.
Gadolinium-based contrast agents are an essential component of MRI exams, but are challenged by findings of residual depositions of gadolinium in the body, even though the clinical relevance remains unknown. Three clinicians described how changes to MRI protocols and dose levels for contrast media can optimise the balance between benefit and risk for patients and radiologists.
Research at the University of Konstanz has identified a molecule that allows the bacterium Pseudomonas aeruginosa to inhibit its rival, Staphylococcus aureus. This might build the basis for the development of new antibiotics.
New MRI techniques are set to offer advances in the earlier detection of liver disease in patients. Radiologists are harnessing the potential of highly-targeted MRI, whilst exploring the imaging modality as a means of delivering non-invasive biomarkers, reducing the need for biopsy to measure treatment response.
NEW: Evolution 3.0 EPIQ ultrasound upgrade offers high-res PureWave crystal transducer technology, shear wave elastography, contrast enhanced ultrasound, and image fusion. Could you ask for more?
First thing on a recent Monday morning, Professor Tomasz Grodzki could be found performing a lung resection in an operating theatre at the Regional Hospital for Lung Diseases in Szczecin-Zdunowo. Just two days earlier he was in a meeting with Senator John McCain, in Washington D.C.
Professor Hans Clevers, researcher and group leader at the Hubrecht Institute in Utrecht, the Netherlands, invented the organoids, a ground-breaking new technique to grow new ‘organs’ and to test medication.
Doctors and scientists at the University of Southampton have used advanced 3D X-ray imaging technology to give new insight into the way an aggressive form of lung disease develops in the body.
‘Already used in adults for several years, elastography is a promising tool in paediatric imaging,’ according to radiologist Dr Mehrak Anooshiravani-Dumont, from Geneva University Hospital. ‘It allows detection of changes in the mechanical properties of tissues, such as fibrosis, based on viscoelastic characteristics.‘
Interstitial lung diseases (ILD) are rare – yet they are far more difficult to diagnose and highly variable. Professor Julien Dinkel, consultant at the Institute of Clinical Radiology, Ludwig Maximilian University Hospital in Munich, deals with these rarities.
After evaluating content on idiopathic pulmonary fibrosis on almost 200 websites, researchers with medical backgrounds found that the information on IPF from these sites was often incomplete, inaccurate and outdated. The study, "Accuracy and Reliability of Internet Resources for Information on Idiopathic Pulmonary Fibrosis" highlights the need for the medical community to continually…
Building on an innovative ultrasound technology that continues to yield break-through capabilities, SuperSonic Imagine is introducing AngioPLUS, a third diagnostic functionality for its Aixplorer platform that promises to be instrumental in the diagnosis of cancerous tissues as well as musculoskeletal pathologies.
Impacting on clinical decisions. Accelerating clinical routine. Following the release of its new Version 6 software upgrade for the Aplio Platinum Series ultrasound system, Toshiba has received high marks for the enhanced functions and performance from practitioners, each offering specific insights into how they are applying the technology.
In a small pilot study, researchers from North Carolina State University have demonstrated a rapid, simple way to generate large numbers of lung stem cells for use in disease treatment. This method of harvesting and growing a patient’s own lung stem cells shows promise in mice for treating idiopathic pulmonary fibrosis (IPF), and could one day provide human IPF sufferers with an effective, less…
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms, which contribute to antimicrobial resistance.
With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs – the community of microscopic organisms that are…
The challenges and advantages of using echocardiography as an invaluable tool in the assessment of Hypertrophic Cardiomyopathy have been highlighted at a major UK cardiology conference.
Adults who are worried or terrified sometimes curl up into a fetal position. Likewise, adult cells that are injured, including genetic injury leading to cancer, initiate a process that was present during embryonic development.
Magnetic resonance imaging (MRI) and computed tomography (CT) provide important information on the symptoms and exercise capabilities of people with mild-to-moderate chronic obstructive pulmonary disease (COPD), according to a new study published online in the journal Radiology. Researchers said the findings point the way to better treatment for some COPD patients.
Publicly insured Americans who undergo lung transplantation for cystic fibrosis fare markedly worse in the long run than both publicly insured patients in the United Kingdom and privately insured Americans, according to the results of a study conducted by researchers from Johns Hopkins in Baltimore and U.K. colleagues working in that nation’s government-funded National Health Service.
MRI is increasingly relevant to cancer management, especially to detect breast carcinoma. Professor Christiane K Kuhl from the department of diagnostic and interventional radiology at the University of Aachen, Germany, strongly advocated in favour of MRI in breast cancer screening during a dedicated Satellite Symposium organised by Bracco at ECR 2015. Report: Mélisande Rouger
Ask about UltraFast ultrasound and you might expect a technical answer explaining why the ultrasound is faster. However, for Stéphanie Franchi-Abella MD, fast means just fast, an ultra-quick acquisition she can take of a squirming, agitated new-born in the blink of an eye. ‘These babies are small and breathing rapidly, the organs are moving fast in the image and it’s sometimes difficult to…
Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty in Mannheim at Heidelberg University are searching for new approaches to prevent liver fibrosis. They have identified a surface molecule on special liver cells called stellate cells as a potential target for interfering with this process. When the researchers turned off the receptor, this led to reduced liver…
Someone once described the fusion of positron emission tomography (PET) and magnetic resonance imaging (MRI) as a great technology looking for an application. Report: John Brosky
Until recently liver biopsies were performed to stage hepatic fibrosis in order to identify the suitable therapy. ‘Since any intervention in the human body is associated with risks – haemorrhage and infection for example – we have long been looking for an alternative method to determine liver tissue elasticity. Today shear wave elastography is exactly such a method,’ says Professor…
The Aplio, Toshiba’s flagship ultrasound scanner, has been extensively advanced and essentially turned into a new system. The highly innovative Japanese company in imaging diagnostics has refined the successful Aplio series of scanners and introduced it internally in Frankfurt at the beginning of October.
Imaging procedures are rarely used to diagnose and treat asthma – but this may well change in the future.
For gastrointestinal exams, MRI fluoroscopy offers an alternative to conventional methods of swallowing and gastric emptying that are so repugnant to patients.
‘Elastography is in a position much like Doppler 20 years ago,’ according to David Cosgrove, BMBCh, MA, FRCR, FRCP, Professor of Clinical Ultrasound at Imperial College School of Medicine in London.
An innovative technology is enabling radiologists to provide more accurate diagnoses.
We must not forget that despite advances, cardiovascular disease remains the number one killer in Europe.
The potential of cardiac magnetic resonance imaging (CMRI) is still largely untapped. One novel application might be ablation follow-up. The first MRI-guided cardiac interventions were performed at Herzzentrum Leipzig, but, as far as coronary imaging is concerned, MDCT remains superior to MRI
Medicine is not immune to prejudices. In the past, the ‘fatty liver’ diagnosis was often accompanied by the hasty conclusion that the problem was surely caused by alcohol abuse.
Across the globe, up to 400 million people carry the hepatitis B virus, and more than 180 million – approximately 400,000 in France – are infected with the hepatitis C virus.
Simultaneous surgical successes open new perspectives for multiple transplants
More anatomy details, real-time visualisation of catheter movement, and reduced exposure – MRI has promising potential in rhythmology, explain Professor Matthias Gutberlet and PD Dr Christopher Piorkowski, at the Heart Centre, University Hospital Leipzig, Germany.
Devised by the European Liver Test group, the new, non-invasive Enhanced Liver Fibrosis (ELF) test on Siemens ADVIA Centaur Immunoassay Systems can identify, in under an hour, bloodbased biomarkers to detect the amount of fibrosis in the liver.
“This is breaking news, which just happens to coincide with the ESTI meeting,” said David Hansell MD, who will present a preview of the as-yet unpublished update to the ATS/ERS classification for idiopathic interstitial pneumonias (IIP).
At first sight magnetic resonance imaging (MRI) does not seem to be particularly well suited for lung diagnostics: too much air, too much movement and too little water make image acquisition a real challenge. Nevertheless, MRI is useful and in certain cases even superior to CT say the members of HTIP (Heidelberg Thorax Imaging Plattform), an association of the radiology departments of the…
If you are new to the ESTI meeting, a resident or a junior in the radiology group, then this is the course you do not want to miss,” says Katharina Marten-Engelke. On Saturday morning, she will moderate a course on HRCT basics from some of the leading experts in the field to provide an overview. The second half of the two-hour course promises to be challenging, even for very experienced…
Will MRI become routine modality? Today, thoracic MRI is rarely performed in Europe. But this will change over the next decade, predicts Professor Hans-Ulrich Kauczor, Medical Director of the Radiology Clinic at University Hospital Heidelberg. He expects Germany to be at the forefront of this development because MRI technology, despite the high costs, is already widely used here and because CT…
“The powerful capabilities for thoracic imaging can often be sufficient to make a diagnosis to treat the patient,” notes Philippe Grenier, MD. If CT findings, for example, are typical for idiopathic pulmonary fibrosis, there should no longer a need for a biopsy, which is good for the patient.
Critical ultrasound, as a tool for immediate therapeutic decisions, and emergency POC ultrasound – an extension of the clinical examination at the bedside or on the accident scene – have shown clear benefits along with lung ultrasound.
The European Research Council (ERC) has earmarked about €2.5 mio. to fund the research being conducted by gastroenterologist and biochemist Professor Dr. Dr. Detlef Schuppan at Mainz University Medical Center. Professor Schuppan is a specialist in liver diseases ranging from fibrosis to cirrhosis (the terminal stage of fibrosis) to hepatic cancer.
A drop of blood can unlock secrets of the heart. By analysing the biological elements present in a blood, a physician can better understand the extent of damage or disease for patients with heart failure and more confidently prescribe a course of treatment.
World of Ultrasound met Prof. Ioan Sporea, Prof. Gebhard Mathis and Prof. Byung Ihn Choi to ask them three questions.
Detecting prostate cancer with transrectal ultrasound using strain elastography is quite tricky: it works by applying pressure to the transducer to measure relative stiffness of tissue, Professor Correas points out and states that ‘more than 80 percent of prostate cancer develops in the peripheral zone which is against the rectal wall. If we apply pressure to this zone the deformation of the…
Although the 17 lectures delivered at this year‘s Medical Technology Congress in Berlin, Germany, focused on topics ranging from experimental and clinical research to routine daily diagnostic methods, the pervading interest was in the improvement, development and distribution of non-invasive imaging devices and corresponding software.
Too much unhealthy food, too little exercise – the risk factors for the development of non-alcoholic fatty liver disease and Type 2 diabetes are not only similar but also form a life-threatening alliance.
In 2005, when they founded the French ultrasound company SuperSonic Imagine, Jacques Souquet PhD and Claude Cohen-Bacrie had to convince radiologists that they not only offered a new product but also a completely new ultrasound technology that could measure entirely new parameters.
Aipermon GmbH & Co. KG reports that cooperations with medical device manufacturers Vitalograph and PARI Pharma have opened up new approaches to telemonitor lung patients.
The 90-minute refresher course ‘Contrast Agent Issues 2010: What the Experts Really Do for Allergies, Contrast-induced Nephropathy, Nephrogenic Systemic Fibrosis, and Extravasation’, to be held during this year’s Radiological Society of North America meeting, will focus on the use of iodinated and gadolinium-based contrast media and the issues, advantages and considerations for patient…
Not only is heart failure one of the single biggest causes of morbidity and mortality in man, but the incidence of the condition is steadily increasing. Rising to this challenge, innovative medical diagnostic techniques with ever greater performance are constantly being introduced so that early, unambiguous detection of the underlying condition is now possible, enabling the prompt initiation of…
Hot topics to be covered during the EuroPCR Forum sessions are the challenging implementation of the best standard of care for STEMI patients throughout Europe (with the timely use of stents), the introduction of transcatheter aortic valve implantation (TAVI) in clinical practice and the challenges related to bifurcation treatment options.
The lungs had to be regarded as the black hole for MRI for a long time. However, since the introduction of substantial improvements in hardware and scanner technology, there is certainly light at the end of the tunnel. MRI offers two main advantages for the diagnostic pathways for pulmonary diseases applied today.
During conventional electro-cardiology, interference from electromagnetic fields (EMFs) tends to diminish image quality due to cardiac motion. To exclude that interference an acoustic cardiac triggering (ACT) approach, also called MR stethoscope, has been developed to trigger cardiac MRI at 7-Tesla.
While biomarkers are acknowledged as useful tools in the early assessment of patient response to treatment, radiologists are less clear on how they can be applied in clinical practice. The ECR session Biomarkers: new word, new world, new work? explored a number of new applications for biomarkers with senior radiologists discussing their relevance in different areas.
Physicians, over many centuries, have depended on the sense of touch as their hands on method to detect diseases in many body areas. This technique is called palpation. However, though it was known that abnormalities in the stiffness or mechanical environment in tissue may have a profound impact on how many diseases progress, conventional imaging modalities could not display tissue stiffness in…
At this year’s ECR, new developments will be outlined during the Contrast agents: Experimental and Clinical session. Mark Nicholls spoke with the session moderator Professor Peter Aspelin, Professor in Diagnostic Radiology at the Karolinska Institute, Stockholm, about their potential.
A recent study determined that repeated liver stiffness measurements (LSM) in the first year following liver transplant (LT) could discriminate between slow and rapid "fibrosers". LSM were extremely accurate, particularly at the 6-month post LT point, in detecting severity of fibrosis. Determining those at risk for a recurrence of hepatitis C virus (HCV) allows for early-stage administration of…
In recent years Hitachi Medical, the pioneer in developing ultrasound elastography to diagnose tissue stiffness, has seen competing systems launched that claim to have the same capability. ‘We are approaching a point where elastography will be considered a standard feature, call it the E-mode, for ultrasound,’ Heinz Schreiber, head of Ultrasound for Hitachi Medical Systems Europe told…
Ultrasound presents a promising technology for non-invasive examinations of the abdomen. There is a vast, unmet medical need in the area of liver fibrosis for the clinical assessment of patients with fibrosis who either refuse or cannot undergo the painful and invasive biopsy procedures that provide hard histological evidence of the state of the disease.
University of Utah researchers have found that delayed-enhancement magnetic resonance imaging (DE-MRI) holds promise for predicting treatment outcomes and measuring disease progression for patients with atrial fibrillation (AF), a little known heart rhythm disorder that affects more than 3.5 million Americans and causes more than 66,000 deaths a year. Their latest study on a novel application of…
In a symposium organised by Bayer Schering Pharma at the 2009 European Congress of Radiology (ECR), the audience heard a series of four presentations on the potential advantages of high-signal-intensity contrast agents for MRI, focusing on gadobutrol (Gadovist). During the discussion, several claims made by the speakers were challenged and debated by ECR delegates.
Working in partnership to integrate diagnostic imaging, laboratory diagnostics and IT, the Hospital Clinic Barcelona and Siemens Healthcare aim to develop innovative systems to prevent, treat and follow-up for various pathologies.
GE Healthcare's first Discovery PET/CT 600-series scanners are being installed in a number of leading clinics around the world. "This first set of installations is a big step forward in the diagnosis and monitoring of disease", said Terri Bresenham, newly appointed vice- president and general manager of GE Healthcare's global Molecular Imaging business.
The clear focus of the numerous lectures given at the International MRI Symposium was on cardiac imaging.
Siemens Healthcare announced the signing of an agreement with Hospital Clinic in Barcelona, Spain, to integrate the use of laboratory diagnostics, imaging and information technology systems with the intent to improve management of patient care from early detection and diagnosis of diseases or conditions to patient treatment.
Siemens Healthcare is showing a very innovative application on the new ACUSON S2000 ultrasound system. “The software packages Virtual Touch tissue imaging and Virtual Touch tissue quantification represent the clinical realisation of a method, previously known as Acoustic Radiation Force Impulse (ARFI) technology”, the firm explains.
Siemens Healthcare will show its Acuson S2000, the first ultrasound system in the new product series S, at the ESC*. The system platform includes integration of the newest technologies to optimise workflow, e.g. comprehensive software applications such as new software for breast imaging.
Siemens Healthcare Diagnostics will showcase the combined strengths of Diagnostics Products Corporation (DPC), Bayer HealthCare Diagnostics and Dade Behring.
Developments in MRI over the last few years have revolutionized the diagnosis and therapy of cardiovascular diseases. Contrast-enhanced MR angiography has established itself as a non-invasive, standard procedure for the diagnosis of vascular diseases in the thorax, abdomen and periphery.
Before discussing a possible connection between gadolinium and nephrogenic systemic fibrosis (NSF), Dr Herborn offered a brief background:
Only few imaging modalities lend themselves to imaging of the lungs. Conventional chest radiography is the most commonly used tool in the investigation of pulmonary pathology but yields the perhaps most difficult, plain radiographs to interpret.
Andrea Martini and Joerg Larsen, of the Institute for Roentgendiagnostics, Braunschweig Teaching Hospitals, Germany, discuss nanotechnology, hybrid imaging and the quest for a personalised medicine.
For individualised radiotherapy, high-precision delineation and characterisation of the tumour is critical. If highest radiation doses are delivered in a targeted fashion, the chance of tumour cell kill increases and tumour control probability is enhanced.
As reported in the January issue of Hepatology, MRI imagery is emerging as a non-invasive way to determine the existence and extent of hepatic fibrosis. It could eventually help the development of pharmacologic strategies to combat the condition.
By Professor György Harmat MD, Director General of the Budapest Municipal Council Pal Heim Children's Hospital, Hungary
Medical imaging is a first order boom area.
Since April, there's been a new man at GE Healthcare´s global MRI division; its new Vice President and General Manager is James E Davis. Meike Lerner caught up with him during the International Society for Magnetic Resonance in Medicine Congress, held recently in Berlin
Already in 1993, the world market for contrast media was thought to be worth $ 3 billion. In 2001, an astonishing 12.2 million contrast medium-supported CT studies were carried out in Europe alone. Currently, the overall sales of contrast media are estimated to rise to $ 915 million in Europe in 2008.
After previous meetings in the USA (2002) and Japan (2004), this October the 3rd International Workshop of Pulmonary Functional Imaging (IWPFI) took place in the German Cancer Research Centre, based in Heidelberg University, Germany. " 'The clinicians' need for earlier and more detailed diagnosis in pulmonary disease demands a joint interdisciplinary effort to push the limits in pulmonary…
In an interview with Daniela Zimmermann, Executive Director of European Hospital, Dr Mohammad Naraghi, Head of the Department of Business Development at Siemens Medical Solutions, discussed developments in moleculary medicine, biochips, preventive diagnostics and a comprehensive and integrated health system for the future.
Dr Christiane Eickelberg, of the University of Giessen Lung Centre (UGLC), outlines the centre's research projects, aims and academic offerings
The Vest Airway Clearance System (which is technique independent and treats all lobes of the lungs simultaneously) helps to mobilise pulmonary secretion via high-frequency chest wall oscillation.
"Céad Mile Fáilte!" said ERS President Walter McNicholas, to greet those about to attend this the 14th Annual Congress of the ERS, (Glasgow, Scotland, 4-8 September 2004).
Implants presently in use consist of a smooth or textured silicone shell filled with a silicone gel or saline solution. The latter has one decisive drawback - the breast may cool considerably in winter. Smooth silicone implants may also shift or turn.
