Image source: Adobe Stock/jijomathai

News • Achromobacter research

Cystic fibrosis: new bacteria discovery could lead to better treatments

New research led by Queen’s University has made a breakthrough in the field of microbiology, which could lead to the development of new treatments for people with compromised immune systems, such as those with cystic fibrosis.

The findings have been published in Cell Reports

Professor Miguel A. Valvano, Chair in Microbiology and Infectious Diseases at the Wellcome-Wolfson Institute for Experimental Medicine (WWIEM) at Queen’s University Belfast and lead researcher on the study, explains: “Achromobacter bacteria can cause chronic and potentially severe infections. However, until now, how this opportunistic bacterium interacts with the human immune system has been poorly understood. These bacteria resist the action of multiple antibiotics; therefore, infection by these microorganisms is very difficult to treat by conventional therapies, especially in people living with cystic fibrosis or other immunocompromising conditions, such as patients on chemotherapy.” 

The research was led by scientists from the Valvano Group in the WWIEM at Queen’s. The research team includes Dr Keren Turton, Ms Hannah Parks and Ms Paulina Zarodkiewicz, and was conducted in collaboration with Dr Rebecca Coll and Dr Rebecca Ingram, also in the WWIEM, and Professor Clare Bryant from the University of Cambridge.

The team discovered that after being engulfed by the body’s immune cells (macrophages), these bacteria can survive within cells using a specialised protein complex (called type III secretion system) to deploy molecules that induce the death of immune cells. Self-destruction of immune cells sounds an alarm that results in the recruitment of other immune cells to fight off invaders. 

However, immune cells deficient in two of the inflammation sensors, called NLRC4 and NLRP3, do not die, suggesting that these two sensors are required for the recognition of the pathogen. The researchers observed that Achromobacter infection leads to damage in lung structure and causes severe illness if the specialised secretory pathway is functional, but not if bacteria carry mutations in the secretion system. This demonstrates that the macrophages’ self-destruct alarm is triggered by the type III secretory system pathway but that this inflammatory response is insufficient for the immune system to defeat the bacteria. 

The next stage of the research is to determine what other virulence proteins are in the Achromobacter armamentarium, helping it survive and invade other cell types in the body. The type III secretion system or other proteins could be useful for developing novel treatments. 

This research was funded by the US Cystic Fibrosis Foundation. 

Source: Queen's University Belfast


Related articles


News • Infection control

Legionnaire's disease: genetic analysis key to understanding risk

Routine sampling of water supplies and genomic sequencing of Legionella bacteria could play a key role in identifying the source of Legionnaires’ disease outbreaks, research suggests.


News • bacterial communities

What’s lurking in your lungs?

With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but…


News • Evolution and host-specific adaptation

Pseudomonas aeruginosa: origins of an epidemic pathogen

How do pathogenic bacteria evolve to become epidemic? To find out, researchers examined DNA data from almost 10,000 samples taken from infected individuals, animals, and environments around the world.

Related products

Subscribe to Newsletter