High-resolution 3D MRI brain vascular map: (a) High-resolution 3D MRI brain...
High-resolution 3D MRI brain vascular map: (a) High-resolution 3D MRI brain vascular map using SAIO. Various blood vessels in the rat brain can be visualized. In addition to clinically important brain vessels including anterior cerebral artery, middle cerebral artery, posterior cerebral artery, fine vessel structures as thin as ~100 microns in diameter can be clearly visualized. (b) 3D MRI brain vascular map using Dotarem (gadolinium-based contrast agent). Resolution is low and microvessels are not visible. (c) For 3D reconstruction, multiple slices of MRI images of the rat heart were obtained after injection of SAIO. Rat coronary arteries (180 microns) which are 10 times thinner than human coronary arteries were successfully visualized. Coronary arteries supply blood to the heart muscle and the blockage or narrowing of such arteries causes myocardial infarction or angina, but visualizing these arteries was impossible due to the limited resolution of current MRI contrast agents.

Image source: Institute for Basic Science

Nanoparticle-based contrast agent SAIO

New MRI contrast agent to improve upon gadolinium-based products

Magnetic resonance imaging (MRI) is widely used to identify the narrowing or blockage of blood vessels. Contrast agents improve the visibility of the structures and offer more accurate information of vascular conditions such as vascular blockage and stenosis.

Commonly used gadolinium-based contrast agents must be administered in chelated forms due to the gadolinium ions' high toxicity and pose health risks of nephrogenic systemic fibrosis for patients with poor kidney functions. There have been some attempts to use paramagnetic iron-based nanoparticles as contrasting agents, but their renal clearance profile must be improved to prevent undesirable accumulation in the liver and other organs. A collaborative research team led by Professor Jinwoo Cheon, the director of the Center for Nanomedicine (CNM), Institute for Basic Science (IBS) at Yonsei University, Seoul, South Korea, and Professor Byoung Wook Choi from Yonsei University College of Medicine developed a high-performance MRI contrast agent for 3D vascular mapping. The researchers developed a nanoparticle-based MRI contrast agent, called SAIO (Supramolecular Amorphous-like Iron Oxide). The particle is 5 nanometers in size, which is about 1,500 times smaller than the microvascular diameter. This allows it to circulate across blood vessels in the body.

The scientists published their insights in the journal Nature Biomedical Engineering.

Photo
Excretion of SAIO: Above: MRI image showing urinary output from the kidneys towards the bladder through the ureters. Below: Rat bladder MRI image before and after the injection of SAIO. Gradual SAIO collection in the bladder is observed. SAIO collected in the bladder is excreted into the urine.

Image source: Institute for Basic Science

SAIO is a special nanoparticle that consist of a polysaccharide core made primarily with dextran cross-linked with other molecules. This core is then coated with an iron oxide surface to give it paramagnetic properties at room temperature. The hybrid nature of the SAIOs gives them both excellent biocompatibility and imaging performance. The researchers compared the contrast performance, retention, and renal clearance profile of the SAIO against Dotarem (a gadolinium-based agent) and iron oxide nanoparticles.

SAIO is one of the highest resolution imaging agents, which is 10 times more precise than the image generated using current contrast agents. It has achieved a 3D brain vascular mapping that can clearly identify brain microvessels as thin as a hair (100 microns) in animal experiments. In addition, to excellent resolution, the enhancement lasts substantially longer (>10 min) in comparison to Dotarem (< 2 min), which gives the radiologist an ample amount of time to carry out the imaging procedures. These excellent properties of the SAIO allowed the researchers to observe the heart blood vessels, which are hardly visible with current MRI contrast agents. 

In addition to having high resolution, excretion of the contrasting agent through urine is especially important to avoid its accumulation within the body, which can cause various side effects. SAIO has an excellent renal clearance profile without accumulation in liver or spleen. It was also found that SAIO was stable without aggregation nor iron leaching for up to a year. Director Cheon said, “SAIO is a next-generation contrast agent that satisfies both high resolution and safety at the same time” and professor Choi said, “SAIO is expected to play a vital role in increasing the accuracy of the diagnosis of cerebro-cardiovascular diseases such as stroke, myocardial infarction, angina, and dementia.”


Source: Institute for Basic Science

11.03.2021

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