Obesity

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News • Hormone activation gone awry

How insufficient insulin processing leads to obesity

Overweight increases the risk of an imbalance in sugar metabolism and even diabetes – but the opposite is also true: insulin production deficits contribute to overweight, a new study shows.

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News • Live bacterial therapeutics

Engineering the microbiome to potentially cure disease

Development of effective live bacterial therapeutics may depend more on using and re-introducing native microbes that can stick around than how the microbes are modified.

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News • Metabolic disorders

Decoding a direct dialog between gut microbiota and brain

Hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and body temperature accordingly.

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News • Obesity

People should focus more on fitness over weight loss

When it comes to getting healthy and reducing mortality risk, increasing physical activity and improving fitness appear to be superior to weight loss.

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News • Cardiology research

Strong connection between heart health and pregnancy complications

A study of more than 18 million pregnancies has shown a strong and graded relationship between women’s heart health and pregnancy outcomes. The research is published in the European Journal of…

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News • Prognosis

Better heart failure outcomes through biomarker-based treatment

In a recent study by University of Alabama at Birmingham researchers, findings indicate that among patients with heart failure, obesity is associated with a higher risk of heart failure…

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Article • Sonography challenges

Abdominal ultrasound: promising for imaging of obese patients

Imagers need special scenarios, skills and tools to examine larger patients, who present more challenges when it comes to radiological procedures. New ultrasound devices could help reduce dose exposure in these patients, who are more likely to undergo x-ray based examinations and receive a higher dose during those, experts explained in a dedicated session during ECR 2020.

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News • Profiling the coronavirus

Risk factors for severe and fatal COVID-19 cases identified

Age, male sex, obesity, and underlying illness have emerged as risk factors for severe and fatal cases of COVID-19 in the UK, according to the largest cohort study to date published by The BMJ. As the largest prospective observational study reported worldwide to date, it provides a comprehensive picture of the characteristics of patients hospitalised in the UK with COVID-19 and their outcomes.…

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News • Surprising side-effects

A new cancer drug (that fights obesity and diabetes, too)

Eric Prossnitz, PhD, from the University of New Mexico Health Services and his team hope to help 93 million obese Americans fight their fat. In a paper published in Science Translational Medicine, they reported that G-1, a cancer-fighting compound they discovered some years ago, reduces fat in obese mice. Although G-1 is currently in phase 1 clinical trials for cancer, Prossnitz and his team are…

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News • Updating treatments

Sugar and fat can make cancer cells harder to kill

In their quest to find new and better methods to make cancer cells more susceptible to treatment, Karin Lindkvist and her research group at Lund University in Sweden are looking into the world of molecules, using the X-rays at the MAX IV laboratory. The researchers believe that limiting the cells' access to sugar will make cancer cells more sensitive to treatment. Many of the cancer treatments…

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News • Obesity, heart disease, diabetes

Are NCD not so "non-communicable" after all?

Diseases such as cardiovascular diseases, cancer or certain lung diseases are among the most common non-natural causes of death today and account for about 70 percent of deaths worldwide. They are defined by the World Health Organization (WHO) as non-communicable because they are assumed to be caused by a combination of genetic, lifestyle and environmental factors and cannot be transmitted…

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News • New nutrition study

Childhood obesity: a surprisingly complex topic

The World Health Organization has estimated more than 340 million children and adolescents ages 5-19 are overweight or obese, and the epidemic has been linked to more deaths worldwide than those caused by being underweight. The Centers for Disease Control recently reported an estimated 1 in 5 children in the United States, ages 12-18, are living with prediabetes — increasing their risk of…

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News • Boosting the microbiome

A vaccine against chronic inflammatory diseases

In animals, a vaccine modifying the composition and function of the gut microbiota provides protection against the onset of chronic inflammatory bowel diseases and certain metabolic disorders, such as diabetes and obesity. This research was conducted by the team of Benoît Chassaing, Inserm researcher at Institut Cochin (Inserm/CNRS/Université de Paris), whose initial findings have been…

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News • Cesarean consequences

C-section increases obesity risk? False alarm, says new study

Women who have C-sections are no more likely to have children who develop obesity than women who give birth naturally, according to a large study by researchers at Karolinska Institutet in Sweden published in the journal PLOS Medicine. The findings contradict several smaller studies that did find an association between C-section deliveries and offspring obesity but did not consider the numerous…

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Article • Surgery to reduce obesity-related mortality

When diet and excercise alone are not enough

Obesity not only means someone is overweight but, over time, they will probably suffer sequelae that increasingly impair quality of life and are potentially fatal – these include hypertension, coronary heart disease, type two diabetes, pulmonary function disorders, tumours, plus an increased risk during surgery and anaesthesia. In patients with morbid obesity, class three obesity, according to…

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News • Fast Food study

More burger joints, more heart attacks

Areas with a higher number of fast food restaurants have more heart attacks, according to research presented at the 67th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ). The study also found that for every additional fast food outlet, there were four additional heart attacks per 100,000 people each year. Study author Tarunpreet Saluja of the University of…

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News • Subgroup detected

A new Diabetes classification?

The traditional classification of diabetes, mainly in type 1 and type 2 diabetes, has been challenged by studies from Scandinavia. In the current issue of The Lancet Diabetes & Endocrinology, researchers from DDZ together with colleagues from DZD and University of Lund published a cluster analysis of diabetes allowing for phenotyping into subgroups, which extended the findings by showing that…

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News • Body fat assessment

BMI for children? Here's a better idea

Researchers at St George's, University of London have developed an accurate equation that will enable medical professionals to accurately predict body fat levels in children using only very simple measurements and other information. The equation takes into account height, weight, sex and age and ethnicity (where available) to predict body fat. The equation has been derived using information from…

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News • Dysbiosis treatment

New prebiotics: benefits without downsides?

Prebiotics are currently a preferred treatment for certain metabolic disorders, as they can restore the balance of dysfunctional gut microbiota, and improve the body’s metabolism. However, these substances have to be used at high doses, which can result in patients experiencing bloating and flatulence. A research group led by Matteo Serino, Inserm researcher at the Digestive Health Research…

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News • Obesity and Type 1 diabetes

Robotic pancreas transplant offers hope

For patients with Type 1 diabetes who don’t respond well to insulin or have other serious medical complications caused by their disease, pancreas transplantation offers hope for a cure. But obese candidates who need a pancreas transplant often are denied the procedure because of poor outcomes, including high rates of incision infections, which are linked to an increased risk for failure and…

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News • Intervention in fat metabolism

Improved diabetes in spite of obesity

Eating too much fat and sugar makes you overweight and unhealthy – even young children know that. But why is that, and is there anything we can do about it? In a study published in the journal Cell, Prof. Jens Brüning's research group at the Max Planck Institute for Metabolism Research in Cologne has shown how altering fat metabolism in the liver can make obese mice thinner, despite eating an…

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News • Crohn’s disease

Adult-onset IBD linked to higher mortality

While the onset of inflammatory bowel disease (ulcerative colitis or Crohn’s disease) in adulthood is tied to a higher mortality, the actual number of deaths has been falling, a Swedish study from Karolinska Institutet published in the journal Gut reports. Now it is a case of ascertaining which of the newer treatments are the most efficacious, say the researchers. Using the Swedish National…

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News • Omega-3

Asthma control: How effective is fish oil really?

Fish oil does not appear to improve asthma control in adolescents and young adults with uncontrolled asthma who are overweight or obese, according to new research published online in the Annals of the American Thoracic Society. In “Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma: A Randomized Trial,” Jason E. Lang, MD, MPH, and co-authors report that four grams…

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News • Blood thinners

Experts' plea for anticoagulant dosage guidelines

Rutgers researchers have found a way to reduce bleeding in patients following bariatric surgery. The study, which appeared in the journal Surgery for Obesity and Related Disorders, was conducted by Luigi Brunetti and Leonid Kagan at the Rutgers Ernest Mario School of Pharmacy in collaboration with Ragui Sadek at Advanced Surgical and Bariatrics of New Jersey. More than 30 percent of adults in the…

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