Takotsubo cardiomyopathy (‘broken heart syndrome’) is a known complication of Guillain-Barré, but not much is known about the association between the two. New research aims to change this.
Osteosarcoma is the most prevalent malignant bone tumor. Now, researchers have developed a machine-learning model to predict the density of viable tumor cells after surgery and chemotherapy treatment.
Much like joints or blood vessels, the brain can be affected by calcifications. This can lead to neurodegenerative disease, but is not well studied. Now, researchers from Norway identified a gene that provides new insights.
US oncologists are exploring a new combined chemotherapy and surgical approach to safely remove advanced pancreatic tumors that were previously considered inoperable.
Women with a type of ovarian cancer known as germ cell tumours have a worse prognosis than men with similar tumours. The five-year survival rate was 98% for men, but 85% for women, a new study finds.
Holding a mobile phone close to the head for an extended amount of time has long been connected to brain cancer. Now, a new study found no hints for an increased risk.
Adults who had amblyopia (lazy eye) in childhood are more likely to experience hypertension, obesity, and metabolic syndrome as an adult, as well as a higher heart attack risk, finds a new study.
New study results explore the long-term effects of infection with Sars-CoV-2, and challenge the idea that vaccine immunity fades quickly.
A new guideline for the diagnosis and treatment of cryptococcosis is designed to support medical staff in handling invasive fungal infections and provide guidance and support in decision-making.
Was dementia already an issue for Hippocrates and his contemporaries? A new analysis of classical Greek and Roman medical texts suggests that Alzheimer's is connected to modern environments.
A simple blood test could help diagnose patients with glioblastoma, the deadliest form of brain cancer, sparing them from undergoing invasive and highly-risky surgery, report UK researchers.
The underlying mechanisms of Guillain-Barré Syndrome (GBS) have remained largely unknown until now. New research now uncovers a pivotal aspect of GBS pathophysiology.
Coronavirus vaccines have showcased the possibilities of messenger RNA (mRNA) technology. Now, a research team aims to put it to use against a rare inherited metabolic disorder.
Clinicians tend to disregard patient self-assessments for their diagnostic decisions, new research suggests – a mistake that might cause those patients unnecessary harm.
While genetic information may lead to better treatments, promises of cost savings are unfounded. Instead, a large additional bill is more likely, according to University of Copenhagen researchers.
It's an important milestone for gene editing technology: a novel treatment for sickle cell disease utilizing CRISPR-Cas9, has now received FDA approval – a first for this type of therapy.
Using small blood vessels grown in the lab, researchers discover how vascular leaks leading to dementia and stroke emerge – and how this damage might be fixed.
Reseachers from the University of Gothenburg propose a new model for adapted triage in emergency care for pregnant women, which could become clinical routine throughout Sweden.
Machine learning and AI are playing an increasingly important role in medicine and healthcare, and not just since ChatGPT. This is especially true in data-intensive specialties such as radiology, pathology or intensive care. The quality of diagnostics and decision-making via AI, however, does not only depend on a sophisticated algorithm but – crucially – on the quality of the training data.
A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.
A new imaging agent can predict early metabolic response to HER2-targeted treatment in metastatic breast cancer patients, according to new research published in the Journal of Nuclear Medicine.
Two out of the four screening tools used by emergency medical services are inadequate for recognising sepsis, according to new research presented at the EUSEM Congress.
An 'encyclopaedia' of protein alterations in soft tissue sarcomas could open the door to a new era of understanding and treatment for this group of rare cancers.
Researchers at Mayo Clinic have developed a 3D prototype of human skin bioprinted to model inflammatory skin disease such as atopic dermatitis — more commonly known as eczema.
Researchers at NIST have been working on several fronts to advance low-field MRI technology and validate methods for creating images with weaker magnetic fields.
Missing crucial doses of medicines and vaccines could become a thing of the past thanks to Rice University bioengineers’ technology for making time-released drugs.
Researchers at Harvard Medical School developed a new tool that promises to improve the way pathologists see and evaluate a tumor by providing detailed clues about the cancer.
A research team from Barcelona studied the liver of Alzheimer's disease mice models, and demonstrated the importance of the liver-brain axis regarding the psychological symptoms of the disease.
Most AI techniques for rare disease diagnosis use anthropometric measurements of European origins, ignoring the genetic and morphological diversity of humans, a new study finds.
Dutch scientists have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer.
Women with triple-negative breast cancer who received multiple antibiotic prescriptions within three years after their cancer diagnosis were more likely to experience disease recurrence and to die from their cancer.
Doctors across all disciplines, with assistance from artificial intelligence, may soon have the ability to quickly consult a patient's entire medical file against the backdrop of all medical health care data and every published piece of medical literature online.
Around 5,500 people with severe developmental disorders now know the genetic cause of their condition, thanks to a major nationwide study in the U.K..
Testing for genetic mutations in urine can detect bladder cancer years before the disease shows clinical symptoms, new research has shown - reaching more than a decade for the most common cancer type.
Combining single-cell data with a self-learning algorithm reveals how structural changes in chromosomes can trigger cancer. This could pave the way for personalized cancer treatments.
Dutch physicians have developed a system to determine the right dose of immunosuppressive drugs for patients to receive a donor liver - to prevent the activation of the Epstein-Barr virus.
A team of researchers from Portugal and Germany tested an innovative solution to classify seizures, the main symptom of epilepsy, using infrared radar and 3D videos.
New changes made to the timetable for the In vitro Diagnostic Medical Device Regulation (IVDR) across Europe could have a significant impact on manufacturers and users, an expert points out. While the extension of the transition period was a welcome step, other changes which were hoped for remain painfully absent.
At this year's Medica tradefair, laboratory medicine, medical technology and life sciences give new impulses to the entire healthcare market - especially in times of the corona pandemic. An overview.
Until now, it was feared that vaccination against Covid-19 could reduce the success of treatment for patients with nasopharyngeal cancer. A recent study now gives the all-clear in this regard.
99mTc-Sestamibi SPECT/CT can aid in the diagnosis of solid renal lesions, especially in cases where contrast enhanced CT findings are inconclusive, according to researchers from the Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis, Missouri.
Despite treatment, chronic lung diseases such as COPD or cystic fibrosis can become so severe that a lung transplant is necessary. Dr Urte Sommerwerck explains which patients might be considered for transplantation and why follow-up is as important as the surgery itself.
Some leukemias evade treatment by changing their appearance and identity through changing the read-out of their DNA, a new study has found.
A simple 'liquid biopsy' blood test could help guide the treatment of children with the cancer rhabdomyosarcoma, a new study reports.
Artificial intelligence (AI) is increasing its foothold in endoscopy. Although the algorithms often detect pathologies faster than humans, their use also generates new problems. PD Dr Alexander Hann from the University Hospital Würzburg points out that the use of AI helpers can affect not only the reporting of findings – but also the person making the findings.
Many consider our eyes to be the windows to the soul. Yet the cornea, the panes of these windows, sometimes need significant repair. Friso Heslinga, PhD, created artificial intelligence models to support surgeons in one of the oldest and most common transplantation procedures.
Recent advances in CT have focused mainly on software, yet new technology could push the modality much further, experts showed at ECR 2022.
Antibiotic prescribing in primary care could be monitored using health insurance data. And reduced with a simple test.
As the monkeypox outbreak continues to spread around the globe, a rare but potentially serious complication of the virus has been discovered.
Vaccination projects across the world are at a pivotal post-Covid moment, according to one of the leading experts in the field. Speaking to Healthcare in Europe ahead of the World Innovation Summit for Health (WISH) congress in Qatar – where vaccination will be a central topic – Dr Jerome Kim said there is an urgent need to regain a ‘positive consensus’ around the value of vaccines. He…
Arthroplasty treatment of fragile patients is a major challenge faced by orthopaedic surgeons. The patients, often geriatric, come with a variety of risk factors and comorbidities that can negatively impact the success of an arthroplasty procedure.
Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.
The critical times in a woman’s life of pregnancy and the menopause – and their relation to heart health – is explored at the ESC. The defined field of gender-specific cardiology is becoming an increasingly important area of focus, experts say.
The overall risk of myocarditis is substantially higher immediately after being infected with Covid-19 than it is in the weeks following vaccination for the coronavirus, a large new study shows.
A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.
The combination of deep-learning reconstruction and a subtraction technique yields promising diagnostic performance for the detection of in-stent restenosis by coronary CTA.
Researchers have identified an enzyme that is a promising new therapeutic target to combat the dangerous bacterial disease melioidosis.
The Covid-19 pandemic has highlighted the importance of the fast and accurate diagnosis of infectious diseases in clinical settings. Harald Maier discusses the implementation of rapid molecular diagnostics in the central clinical diagnostics laboratory at Innklinikum Altötting and Mühldorf, highlighting how the use of PCR testing has benefitted the hospital during the Covid-19 pandemic.
By comparing the neutralisation capacity induced by the different variants of SARS-CoV-2, a team from Geneva reveals the exceptional capacity of Omicron to evade our immunity.
A research group from Kyoto developed two in vitro models to study SARS-CoV-2, and showed that they can be used for drug screening for infectious diseases including Covid-19.
Researchers at the Georgia Institute of Technology have developed a smart stent that can monitor hemodynamic parameters. The wireless and battery-free device can transmit the data to the outside of the body.
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
Personalised screening, data-driven aproaches: In a dedicated press conference in Paris, French oncologists presented promising research that might bring hope for many cancer patients.
The diagnosis is rare, but devastating – children with congenital muscle disorders often never learn to walk. Now, researchers from Basel present a possible therapeutic approach for the first time.
Reducing inflammatory mediators in the blood before surgical treatment of cardiac bacterial infection does not improve clinically relevant outcome, a new study shows.
A DNA test has been shown to identify a range of hard-to-diagnose neurological and neuromuscular genetic diseases quicker and more-accurately than existing tests.
Cardiac rehabilitation can be done just as well at home as in the hospital. This is the conclusion of the most extensive research into ‘tele-rehabilitation’ to date.
There has to date been no reliable objective method of diagnosing tinnitus. Now, Swedisch researchers may have found a way to measure changes in the brain associated with constant tinnitus.
Faulty versions of the BRCA1 and BRCA2 genes are well known to increase the risk of breast and ovarian cancer. Now, they have been linked to several other cancers, including those that affect men.
A connection between the Epstein-Barr virus and multiple sclerosis has long been suspected. A new study provides ‘compelling evidence of causality’.
A mutation in the gene that causes fibrodysplasia ossificans progressiva (FOP) doesn’t just cause extra bone growth but is tied to a problem in generating new muscle tissue after injury.
In both the mice and organoids, cytokines suppressed tumor growth after treatment, and defense cells migrated to the brain region affected by the tumor, alerting the immune system to its existence.
Does artificial intelligence (AI) need more diversity? This aspect is brought up by experts in the context of AI systems to diagnose skin cancer. Their concern: images used to train such programs do not include data on a wide range of skin colours, leading to inferior results when diagnosing non-white patients.
Progress in miniaturising sensor technology has opened up new possibilities for monitoring vital signs outside the hospital environment. A subset of wearables are the so-called hearables – in-ear devices that are well suited for long-term monitoring as they are non-invasive, inconspicuous and easy to fasten. Hearables offer two major benefits: their proximity to the torso and vascular system of…
Mark Nicholls reports from the National Cancer Research Institute (NCRI) virtual Festival, with four expert speakers discussing the role of liquid biopsy in cancer detection.
Radiologists in Paris have developed a standardised simple visual lung damage CT severity score for Covid-19 patients who do not have symptoms of severe acute respiratory syndrome (SARS) at the time of initial treatment.
Since its introduction around 60 years ago, the screening of newborn babies for immune, hormone and metabolic disorders has prevented many people from experiencing severe disease progression. The scope of systematic early testing has been significantly enhanced through mass spectrometry (MS). In our interview, Professor Uta Ceglarek, one of the driving forces behind the introduction of MS…
Genomics England, a government owned company, recently announced a pilot programme of whole genome sequencing to screen for genetic diseases in 200,000 healthy seeming newborns. But should every newborn baby have their whole genome sequenced? Experts debate the issue in The BMJ. Extensive clinical evidence has shown that screening for genetic diseases saves lives, and research has shown that it…
In May 2022 a shortage of several lab tests may come as many manufacturers struggle to comply with EU regulation requirements covering in vitro diagnostic medical devices (IVDR, Regulation (EU) 2017/746). Even modified tests and laboratory-developed tests will present a problem for hospitals and labs as explained by Dr Thomas Streichert.
Whole genome sequencing (WGS) from a single blood test picks up 31% more cases of rare genetic disorders than standard tests, shortening the ‘diagnostic odyssey’ that affected families experience, and providing huge opportunities for future research.
Autoimmune hepatitis (AIH) is a chronic liver inflammation that is triggered by an immunological malfunction. In this case, the immune system falsely recognises the patient's own liver cells as "foreign to the body". The symptoms of this rare liver disease are unspecific, and the exact cause is not yet known. If left untreated, AIH can lead to abnormal scarring (fibrosis) of the liver,…
Long COVID symptoms rarely persisted beyond 12 weeks in children and adolescents unlike adults.
A new mechanism that stops the progression of Huntington’s disease in cells has been identified by scientists at the University of Cambridge and University College London (UCL), as part of their research groups at the UK Dementia Research Institute. Researchers say the breakthrough study, published in Cell Reports, could lead to much needed therapies for the rare genetic disease, which is…
Researchers from the University of Oxford have announced the results of a study into thrombocytopenia (a condition with low platelet counts) and thromboembolic events (blood clots) following vaccination for Covid-19, some of the same events which have led to restricted use of the Oxford-AstraZeneca vaccine in a number of countries.
The goal of tumour conferences is to determine the best treatment for patients with complex cancers – however, the patient is rarely present. Now, a team of researchers has investigated whether cancer patients can benefit from participating in these meetings.
Italy, France, and Greece have made Covid-19 vaccination mandatory for healthcare workers, and England is making it compulsory for care home workers and consulting on whether to extend this to healthcare workers and other social care staff. Experts debate in The BMJ whether frontline health and social care workers should be compelled to take up the vaccine, if efforts to encourage them fail.…
Roche announced the decision to discontinue dosing in the Phase III GENERATION HD1 study of tominersen (previously IONIS-HTTRx and RG6042) in manifest Huntington’s disease (HD). The decision was based on the results of a pre-planned review of the data from the Phase III study conducted by an unblinded Independent Data Monitoring Committee (iDMC). The iDMC made its recommendation based on the…
The Covid-19 pandemic continues to impact people’s health across the world. This goes beyond the disease itself, as healthcare systems adapt how they provide services. Routine screening has been severely affected with screening programmes reduced or paused.
Pancreatic cancer is one of the deadliest cancers in the world, and one of the most difficult to treat. In 2020, an estimated 495,000 individuals worldwide were diagnosed with pancreatic cancer and an estimated 466,000 died, according to statistics from the World Health Organization’s International Agency for Research on Cancer. Most patients with advanced disease die within a year of…
A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities. The study, led by researchers at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine, offers new hope to those living with incurable genetic and neurodegenerative diseases.
The net benefit of vaccinating children is unclear, and vulnerable people worldwide should be prioritised instead, say experts in The BMJ today. But others argue that Covid-19 vaccines have been approved for some children and that children should not be disadvantaged because of policy choices that impede global vaccination.
Queen Máxima of the Netherlands, after whom the Princess Máxima Center for Pediatric Oncology in Utrecht is named, along with several representatives of the center, the Hopp Children’s Cancer Center Heidelberg (KiTZ), University Hospital Heidelberg (UKHD) and the German Cancer Research Center (DKFZ), signed a memorandum on strategic cooperation in the field of pediatric oncology in Europe at…
Integrating laboratory functions on a microchip circuit is helping improve the cost-effectiveness of drug development. So-called ‘lab-on-a-chip’ or ‘human-on-a-chip’ technology can highlight which treatments may, or may not, work before advancing along the clinical trial process. It can also have benefits for chronic and rare diseases, as well as helping shape personalised medicine.…
University of Washington researchers have discovered that AI models—like humans—have a tendency to look for shortcuts. In the case of AI-assisted disease detection, these shortcuts could lead to diagnostic errors if deployed in clinical settings.
Identifying new uses for approved therapeutic drugs continues to drive academics and clinicians to provide safe, affordable and rapid development of new treatment options for patients with common or rare diseases.
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
The American Institute of Ultrasound in Medicine (AIUM) and the American Society of Echocardiography (ASE) have joined the International Contrast Ultrasound Society (ICUS) in recognizing the relatively low risk and important clinical benefits of ultrasound contrast agents (UCAs), which are used routinely around the world to help detect heart disease, stratify the risk of heart attack or stroke,…
In Sweden, there are over 2 million legally owned firearms. At the same time, up to 150,000 people live with a diagnosis of dementia. In an aging society such as Sweden, legislators will face challenges in gun ownership. A new registry-based observational study by researchers from NVS, Karolinska Institutet, published in the Journal of Alzheimer’s Disease shows a need for strategies for this…
Determining safe yet effective drug dosages for children is an ongoing challenge for pharmaceutical companies and medical doctors alike. To make drugs and their development safer for children, researchers at Aalto University and the pharmaceutical company Novartis have developed a method that makes better use of available data.
Tiny 3D models that mimic vital aspects of the human nervous system have been developed in a step that could accelerate drug research for neurological conditions such as multiple sclerosis (MS). The millimetre-wide models – created using stem cells from human skin samples – will be used to study myelin, an insulating substance that helps nerve cells communicate with each other. Researchers…
CT scanning used to uncover remnants of malignancy hidden inside medieval bones provides new insight into cancer prevalence in a pre-industrial world. The first study to use x-rays and CT scans to detect evidence of cancer among the skeletal remains of a pre-industrial population suggests that between 9-14% of adults in medieval Britain had the disease at the time of their death. This puts cancer…
A chemist from Purdue University has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types.
Intrahepatic cholangiocarcinoma (ICC) develops within the liver. With one to two cases per 100,000 inhabitants in Germany, ICC is one of the rare diseases overall, but it is the second most common liver cancer. The aggressive bile duct tumour remains clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited…
In the largest study of its kind to date, researchers at Massachusetts General Hospital, Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard have found the new mRNA Covid-19 vaccines to be highly effective in producing antibodies against the SARS-CoV-2 virus in pregnant and lactating women. They also demonstrated the vaccines confer protective immunity to newborns…
It is possible to identify Parkinson’s Disease based on compounds found on the surface of skin, according to new research. The findings offer hope that a pioneering new test could be developed to diagnose the degenerative condition through a simple and painless skin swab. Scientists at The University of Manchester have developed a technique which works by analysing compounds found in sebum -…
Diphtheria – a relatively easily-preventable infection – is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India. The researchers, led by scientists at the University of Cambridge, say that the impact of Covid-19 on diphtheria vaccination schedules, coupled with a rise in…
Digital Covid-19 ‘symptom checkers’ may stop some patients from getting prompt treatment for serious illness, suggests an international case simulation study. Both the US and UK symptom checkers consistently failed to identify the symptoms of severe Covid-19, bacterial pneumonia, and sepsis, frequently advising these cases to stay home, the findings indicate. The availability and use of…
Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors. Tens of…
One of the leading figures in global radiology has highlighted the importance of fostering a strong eco-system to advance the safe and effective implementation of AI in medical imaging. Dr Geraldine McGinty said that to fully leverage the power of AI, all stakeholders must work together but underlined the unique responsibility physicians have to ensure patient interests are best served.
With a growing number of Artificial Intelligence (AI) algorithms to support medical imaging analysis, finding the best solution for specific radiology tasks is not always straightforward. Many are cloaked in secrecy and commercial sensitivity and while an algorithm may perform well in one area, evidence of performance and adaptability in another environment is not always available.
Preventing air contamination in healthcare facilities is crucial to minimise the airborne spread of Covid-19 and its new strains. Universal masking, rigorous use of and safe disposal of PPE, plus building ventilation are vital. Twenty-four studies reporting hospital SARS-CoV-2 air contamination are summarised in a meta-analysis by a multi-institutional team of French researchers. These show that,…
Researchers at the University of Maryland School of Medicine (UMSOM) and their colleagues published a new analysis from genetic sequencing data of more than 53,000 individuals, primarily from minority populations. The early analysis, part of a large-scale program funded by the National Heart, Lung, and Blood Institute, examines one of the largest and most diverse data sets of high-quality whole…
A way of using machine learning to more accurately identify patients with a mix of psychotic and depressive symptoms has been developed by researchers at the University of Birmingham. Patients with depression or psychosis rarely experience symptoms of purely one or the other illness. Historically, this has meant that mental health clinicians give a diagnosis of a ‘primary’ illness, but with…
This FAQ from the American College of Allergy, Asthma and Immunology is provided to help answer patient questions about COVID-19 vaccines. These recommendations are based on best knowledge to date, but could change at any time, pending new information and further guidance from the FDA or CDC.
Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases.
MRI is the most sensitive method to detect breast cancer. However, the current breast cancer guidelines for Europe, Germany and Austria, still only recommend it for certain indications: For early detection in high risk patients, for differentiation between scarring and recurrences after breast-conserving treatment and to detect cancers of unknown primary site. This is the theory. However, in…
A new generation of tissue microarrays are delivering more efficient and time-effective solutions to answering complex clinical and scientific questions. Sitting at the core of this new approach is digital pathology, allowing specific and targeted analysis of small areas of tissue.
Scientists have known for years that mutations in the MLL4 gene can cause Kabuki syndrome, a rare developmental disorder. How exactly this happens remeained a mystery for long. Now, a new study illuminates new details. The research suggests that MLL4 controls the production of neurons that secrete growth hormone-releasing hormone (GHRH) in a part of the brain called the hypothalamus. Mice without…
So far, little research has been done on the risk of children being seriously affected by Covid-19 when the schools were open. A study from Karolinska Institutet has now shown that one child in 130,000 was treated in an intensive care unit on account of Covid-19 during the period March-June. The study has been published in New England Journal of Medicine.
A promising approach to treating cancer—called targeted alpha-particle therapy or TAT—could better harness the curative power of radiation treatments and lessen the severity of their more debilitating side effects.
A study of over a thousand cancer patients treated with immunotherapy drugs has found these patients are at greater risk of heart problems, including death from heart attack or stroke. The patients had either lung cancer or malignant melanoma (a type of skin cancer), for which immune checkpoint inhibitors such as a programmed cell death-1 (PD1) inhibitors or cytotoxic T-lymphocyte-associated…
In recent years, targeted therapies have cemented their place as some of the most important tools in cancer treatment. These medicines are designed to block specific signals that tumor cells use to grow and spread, while at the same time leaving normal cells unharmed. Targeted therapies can significantly extend patients’ lives, but the benefits are often only temporary. Over time, many cancers…
Covid-19 causes characteristic changes in lung tissue visible in CT scans and chest radiographs, known as “ground-glass” opacities. Imaging is now considered a valid alternative, possibly even superior to RT-PCR. ‘This sparked an international debate about the role of CT in the diagnostic work-up of Covid-19,’ said radiologist Professor Cornelia Schäfer-Prokop.
To target ionised radiation as precisely as possible, imaging a tumour is vital in radiotherapy planning. ‘Today, imaging is used increasingly during the therapy itself,’ explained Professor Mark Ladd during the 51st annual meeting of the German Society for Medical Physics (DGMP).
Acute stroke in children has the same incidence as brain tumours and can seriously affect a patient’s life. Two kinds of arteriopathies are common drivers of paediatric acute stroke and radiologists must learn to distinguish their signs as early as possible to improve prognosis, according to Béatrice Husson, a paediatric radiologist at Le Kremlin Bicêtre Hospital in Paris.
Infertility has long been attributed to women alone, but medical advances have shown it really is a couple’s problem, with 20% of couples presently having trouble conceiving. Medical imaging, in particular ultrasound, can help identify underlying causes of men’s infertility and other related health issues, an Italian radiologist explained during the last European Congress of Radiology.
Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer.
‘Mini-lungs’ grown from tissue donated to Cambridge hospitals has provided a team of scientists from South Korea and the UK with important insights into how COVID-19 damages the lungs. Writing in the journal Cell Stem Cell, the researchers detail the mechanisms underlying SARS-CoV-2 infection and the early innate immune response in the lungs.
Is mammography still the best method for breast cancer screening? For a number of breast cancers, the latest scientific findings suggest otherwise. For more than a decade, Professor Christiane Kuhl MD, Director of the Clinic for Diagnostic and Interventional Radiology at the University Hospital RWTH Aachen, has researched the use of MRI in breast cancer screening.
A team of researchers in the US and Australia have developed a way of testing potential drugs for children’s cancers so as to take account of the wide genetic diversity of these diseases. In new research to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Professor Peter Houghton, director of the Greehey Children’s Cancer Research Institute (San…
As President Trump claims that he is immune to COVID-19 and isolated reports emerge of reinfection, what is the truth about immunity to COVID-19? To date, there have been six published cases of COVID-19 reinfection, with various other unverified accounts from around the world. Although this is a comparably small fraction of the millions of people known to have been infected, should we be…
A deadly combination of two mosquito-borne viruses may be a trigger for stroke, new research published in the The Lancet Neurology has found. University of Liverpool researchers and Brazilian collaborators have been investigating the link between neurological disease and infection with the viruses Zika and chikungunya. These viruses, which mostly circulate in the tropics, cause large outbreaks of…
For cardiology patients fitted with an implantable cardiac monitor, cardioverter defibrillator (ICD) or pacemaker, home monitoring is a blessing. The system also has many advantages for medical staff, as Kristina Rauholt reports. The nurse and Certified Cardiac Device Specialist for Allied Professionals (CCDS) at the Sahlgrenska University Hospital, in Sweden, has worked with home monitoring…
A Hong Kong man who recovered from COVID-19 was infected again four-and-a-half months later in the first documented instance of human re-infection, researchers at the University of Hong Kong reported.
“Spinocerebellar ataxias” are diseases of the nervous system associated with a loss of motor coordination. A European research alliance headed by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn has now registered whether and how symptoms of ataxia developed over the years in around 250 persons at risk, who initially did not show symptoms. This is the first…
If a father or brother has prostate cancer, his son or brother has an increased risk of this type of cancer. Whether this also applies when precancerous stages of this cancer are discovered in relatives has not yet been known. Now scientists have analyzed data from more than six million men to find out how high the risk of prostate cancer is in this case. Researchers at the German Cancer Research…
A new study from the USA highlights how low temperature sterilisation can jeopardise effective cleansing of medical tools and lead to transmission of dangerous bacteria to patients. Steam sterilisation was shown to be the most effective and robust sterilisation technology. However, the researchers, working at the University of North Carolina, also showed that vaporised hydrogen peroxide (VHP)…
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.
A collaboration led by the Royal Ontario Museum (ROM) and McMaster University has led to the discovery and diagnosis of an aggressive malignant bone cancer — an osteosarcoma — for the first time ever in a dinosaur. Examples of malignant cancers are very rare in the fossil record. The paper was published in the journal The Lancet Oncology. The cancerous bone in question is the fibula (lower…
A diet high in sugar increases the likelihood of developing pancreatic cancer in some people and can also drive the aggressive growth of tumours, a new study finds. During this study, researchers from the University of Surrey, VIB-KU Leuven, Belgium and the Babraham Institute in Cambridge, sought to understand the impact of diet on the development and progression of pancreatic cancer. This rare…
Medtech company BellaSeno announced the initiation of a first-in-human trial of its novel, absorbable soft tissue reconstruction scaffold (Senella). A patient with Pectus Excavatum congenital defect has undergone surgery at Princess Alexandra Hospital in Brisbane, Australia, earlier this month. The procedure was performed by Dr. Michael Wagels, Principal Investigator of the trial and Plastic and…
There are major complications from COVID-19 – ARDS, pulmonary embolism and neurological – that imaging can help detect, manage and/or follow up in the long term, radiologists from France and the UK explained during a recent ESR Connect session. ARDS is the most dreaded complication and the number one morbidity in COVID-19 patients. The incidence was up to 30% of patients in initial reports.…
To investigate rare diseases, applying image-based analytics approaches, including the use of deep learning convolutional neural networks (DL-CNNs), can be a major challenge due to great difficulties in acquiring sufficient numbers of cases and associated digital image sets from the small cohorts typically available. To realise algorithms that are both effective and generalisable, conventional…
Johns Hopkins scientists report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye.
The COVID-19 pandemic has affected children with direct impacts of the infection as well as on them leading normal lives. Schooling, play and vaccinations are among issues that can affect children’s health. Delay in taking paediatric patients to the emergency room (ER) has also had a negative impact, for example late treatment of acute appendicitis. Two experts from Spain tackled these topics…
The first round of results from an immunological study of 149 people who have recovered from COVID-19 show that although the amount of antibodies they generated varies widely, most individuals had generated at least some that were intrinsically capable of neutralizing the SARS-CoV-2 virus. Antibodies vary widely in their efficacy. While many may latch on to the virus, only some are truly…
The Plasma Protein Therapeutics Association (PPTA) is concerned about the recommendations contained in 20th version of Blood Guide of The European Directorate for the Quality of Medicines (EDQM) which aims to harmonise standards and recommendations on blood collection, preparation, and the use of blood and blood components. This Guide, if applied, will have a negative impact on the availability…
Almost five years ago, the plan to implement a wide-ranging digital pathology approach across the Netherlands began to take shape. As more labs across the country acquire digital pathology capability, with steps to create a strong and accessible image repository and a national image exchange platform, one of the project leaders, Professor Katrien Grünberg, offered an update and spoke of some…
Bringing molecular and digital pathology closer together through a more integrative approach can lead to clear advantages for diagnostic and research workflows. During the recent Digital Pathology and AI Congress (London), Professor Viktor Koelzer explored the benefits and paid particular attention to colorectal cancer (CRC).
The Central Laboratory at the Medical University Hanover, Germany, is prepared to handle virtually any clinical chemistry task, from a routine test to the most complex analysis. Equipped with state-of-the-art technology and thanks to a high degree of automation, the team can process more than 3,000 specimens, mostly blood and urine, in a single day. Professor Ralf Lichtinghagen, European…
Computational pathology has increased applications for diagnosis, prediction of prognosis and therapy response, facilitating the movement of healthcare towards personalised medicine. Coupled with deep learning, such tools are ever more efficient and robust within research and clinical settings. The growing role of computational pathology was highlighted by Professor Andrew Janowczyk at the…
Chest X-ray is the first imaging method to diagnose COVID-19 coronavirus infection in Spain, but in the light of new evidence this may change soon, according to Milagros Martí de Gracia, Vice President of the Spanish Society of Radiology (SERAM) and head of the emergency radiology unit at La Paz Hospital in Madrid, one of the hot spots for viral re-production of COVID-19.
Non-alcoholic fatty liver disease (NAFLD) is mostly diagnosed in overweight and obese people. However, severe forms of NAFLD can also be detected in rare genetic diseases such as lipodystrophy or in patients with HIV, putting them at a high risk for developing liver failure, diabetes and cardiovascular diseases. Norbert Stefan and colleagues have now detected a yet unknown cause of NAFLD in lean…
A surprising discovery about a rare form of childhood brain cancer suggests a new treatment approach for that cancer – and potentially many others. Researchers at the University of Virginia School of Medicine have determined that the supposedly simple cancer, called medulloblastoma, forms an unexpectedly intricate network to drive its growth. Some tumor cells actually turn into another type of…
The novel coronavirus that recently originated in Wuhan, China has grabbed headlines and caused concern among public health officials around the world. Two infectious disease experts share their insights on the novel coronavirus epidemic.
Obesity not only means someone is overweight but, over time, they will probably suffer sequelae that increasingly impair quality of life and are potentially fatal – these include hypertension, coronary heart disease, type two diabetes, pulmonary function disorders, tumours, plus an increased risk during surgery and anaesthesia. In patients with morbid obesity, class three obesity, according to…
AI has made headlines for years, including in such scientific publications as ‘Nature’, an indication of its high relevance, according to Dr Tobias Müller, Head of Digital Transformation at the Rhön-Klinikum AG. However, he also delivers a note of caution because studies are often aimed at demonstrating the equivalence of AI-based diagnoses with those made by doctors. ‘You have to read…
For the first time, scientists at Newcastle University have identified changes in the DNA of the tumour cells in those with CYLD cutaneous syndrome (CCS) that may help them grow. A study published in Nature Communications suggest that the tumour cells gain a ‘survival advantage’ when the changes occur – an important step in understanding ways to develop treatments. CCS is a hereditary…
It is an important step towards fighting one of the deadliest viruses known to man: The human medicines committee (CHMP) of the European Medicines Agency (EMA) has recommended granting a conditional marketing authorisation in the European Union for Ervebo (rVSVΔG-ZEBOV-GP), the first vaccine for active immunisation of individuals aged 18 years and older at risk of infection with the Ebola virus.…
A smartphone application has been developed that can help parents detect early signs of eye disease by searching their children’s photographs for traces of leukocoria, also known as “white eye”. The CRADLE app (ComputeR Assisted Detector LEukocoia) searches for traces of abnormal reflections from the retina called leukocoria or “white eye,” a primary symptom of retinoblastoma, as well…
Artificial Intelligence (AI) is like a huge blanket that can cover anything from innocuous chess computers to robots which, depending on your viewpoint, could save, oppress or obliterate humanity. However, not every jar labelled AI contains AI. So what is intelligence and can it be created artificially, synthesised like a nature-identical flavouring substance?
Patients with the rare Loeys-Dietz syndrome suffer from aortic enlargement which may result in sudden over-expansion and a fatal aortic tear. In order to prevent this from happening, an aortic prosthesis must be implanted. A team of vascular surgeons at the University Hospital of Zurich was one of the first in the world to risk undertaking this life-saving operation on a child as an emergency…
New simulation technology developed by TU Graz is designed to make the production of biopharmaceuticals more efficient, cost-effective and comprehensible for manufacturers.
A new technology has brought researchers one step closer to a future cure for Congenital Muscular Dystrophy type1A, a devastating muscle disease that affects children. The new findings are based on research by Kinga Gawlik at Lund University, Department of Experimental Medical Science, and were recently published in Nature. Congenital Muscular Dystrophy type1A, MDC1A, a progressive genetic…
A study led by the University of Birmingham provides strong support for current recommendations on treating patients with an underactive thyroid and validates latest UK and US guidelines, say researchers. The retrospective cohort study, published in The BMJ, analysed anonymous GP records of over 162,000 patients who have been diagnosed with hypothyroidism – a highly prevalent condition more…
More than 1,125,000 men around the world have the inherited bleeding disorder of hemophilia, and 418,000 of those have a severe version of the mostly undiagnosed disease, says a new study led by McMaster researchers. This is three times what was previously known. Only 400,000 people globally were estimated to have the disorder which is caused by a defect in the F8 or F9 gene which encodes…
The U.S. Food and Drug Administration approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. It is the first FDA-approved treatment for this rare lung condition. “Patients suffering from scleroderma need effective therapies, and the FDA supports the efforts…
A remarkable number of studies and innovations were presented at the 30th anniversary of Transcatheter Cardiovascular Therapeutics (TCT) meeting in San Diego, California. TCT 2019 will take place in San Francisco, CA between 25-29-Sep-2019. On the clinical side, the long-expected results from COAPT trial studying MitraClip device in patients with secondary mitral regurgitation and heart failure…
La Fe University and Polytechnic Hospital in Valencia, Spain, is coordinating EU-funded program PRIMAGE, which uses precision information from medical imaging to advance knowledge of the most lethal paediatric tumours, by establishing their prognosis and expected treatment response using radiomics, imaging biomarkers and artificial intelligence (AI).
In its latest draft guidance, the U.S. Food and Drug Administration (FDA) encourages inclusion of males in breast cancer clinical trials. Historically, males either have not been included in clinical trials for drugs to treat breast cancer or inclusion of males in those trials has been very limited; when finalized, the draft guidance will provide clarity for industry regarding clinical…
Kiel biochemistry research team proves the existence of a previously unknown alternative cholesterol transport mechanism inside cells. Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighbouring cells and the surrounding environment. By means of certain proteins,…
The key challenges and opportunities surrounding High-Content Screening have been outlined in a presentation to leading scientists and technologists at a major lab conference. Speaking at the recent SLASEurope 2019 event in Barcelona, Professor Matthias Nees from the Institute of Biomedicine in the Department of Biology at the University of Turku, Finland, outlined the potential of High-Content…
A new study harnessed the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves.
Global warming may have played a pivotal role in the emergence of Candida auris. According to a new study published in mBio, an open-access journal of the American Society for Microbiology, C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change.
In view of the increase of multidrug-resistant organisms (MDRO), the WHO has declared antibiotic resistance one of the biggest threats to global health. MDROs have become a major problem particularly in hospitals. Professor Dr Georg Häcker from the Institute for Microbiology and Hygiene at the University Hospital Freiburg, explains some strategies to prevent hospital-acquired infections (HAIs).
Half of Ebola outbreaks have gone undetected since the virus was discovered in 1976, scientists at the University of Cambridge estimate. The new findings come amid rising concern about Ebola in the Democratic Republic of Congo, and highlight the need for improved detection and rapid response to avoid future epidemics.
An international group of researchers has found that antibodies to the human papilloma virus type 16 (HPV16) develop in the body between six to 40 years prior to a clinical diagnosis of throat cancer, and their presence indicates a strong increased risk of the disease.
A proof-of-principle study shows that gold nanoparticles loaded with CRISPR and other gene-editing tools safely and effectively edited blood stem cells.
Neonatal exposure to nicotine alters the reward circuity in the brains of newborn mice, increasing their preference for the drug in later adulthood, report researchers at University of California San Diego School of Medicine in a study published in Biological Psychiatry. A UC San Diego School of Medicine team of scientists, headed by senior author Davide Dulcis, PhD, associate professor in the…
Point-of-care testing (POCT) is complex and its development continues due to digitisation in healthcare and increasing international partnerships among the healthcare actors. In a hospital, a number of factors need consideration to fully exploit the potential of bedside testing. POCT instruments and analysis methods must be thoroughly validated and quality assurance processes be in place.…
A new vaccination for malignant astrocytoma brings such patients hope. However, research is still in its infancy. We spoke with Professor Michael Platten, Medical Director of the Neurological Clinic at Medical University Mannheim, about the present state of research and the serious opportunities this presents. During the interview, he also revealed how cooperation with the pharmaceutical industry…
The U.S. Food and Drug Administration (FDA) approved Vyndaqel (tafamidis meglumine) and Vyndamax (tafamidis) capsules for the treatment of the heart disease (cardiomyopathy) caused by transthyretin mediated amyloidosis (ATTR-CM) in adults. These are the first FDA-approved treatments for ATTR-CM. Vyndaqel and Vyndamax have the same active moiety, tafamidis, but they are not substitutable on a…
Today, on the occasion of the international DNA day, imec, a world-leading research and innovation hub in nanoelectronics and digital technologies, and its partners revealed their Genome Analytics Platform (GAP) platform, a unique platform that can perform a full genome analysis of 48 samples in only 48 hours and at an acceptable cost. The platform paves the way to genome sequencing as a daily…
Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of chordomas in advanced stages after conducting gene analysis. Their findings, published in the journal Nature…
Babies born with congenital hyperinsulinism (CHI) are at risk of suffering from permanent brain damage and life-long disability. Yet some will go on to suffer more severely than others as a result of their disease profile, report the researchers in an article published in Frontiers in Endocrinology. The research team have found that it is possible to predict when and how the disease may affect…
Neurological complications due to infections with (novel) enteroviruses are rarely the focus of medical research. Thus, an article published in the German medical journal Der Nervenarzt (published at the Medizinische Hochschule Hanover (MHH) – has created quite a stir. We spoke with one of the authors, Professor Martin Stangel, about current clinical practice in terms of enterovirus.…
Artificial intelligence (AI) continues to drive radiologists’ discussions. Among them, Associate Professor Georg Langs, head of the Computational Imaging Research Lab (CIR) at the University Clinic for Radiology and Nuclear Medicine at the Medical University of Vienna, believes: ‘The evaluation of patterns in data from imaging examinations and clinical information about patients using machine…
White matter on the brain is a difficult subject. Even the terminology is varied, making differential diagnosis complex. An understanding of prevalence and of the tools available to facilitate the diagnosis of individual diseases is important, Dr Gunther Fesl, radiologist at Praxis Radiologie Augsburg, explains.
Scientists at Newcastle University believe it may be possible to reverse the damage in the heart caused by ageing. New research, which has been published in the journal EMBO, could suggest a new way of preventing heart failure in older patients. Heart failure occurs when the heart is not pumping blood around the body as well as it should, most commonly when the heart muscle has been damaged –…
According to the Swedish Knee Arthroplasty Register, knee arthroplasty – with a revision rate of five percent after ten years – is one of the most successful surgical interventions of the post-World War II decades. The most frequent reasons for revision are loosening or infections, whereas patient dissatisfaction is often caused by mobility impairment and pain. Since many adverse events are…
Several research groups at Berlin Institute of Health (BIH) are working on digitally combating cancer. The main goal is to combine and jointly evaluate existing information. With 500,000 new cancer cases every year in Germany alone, it is worthwhile comparing experiences with different diagnostic and treatment methods, thus allowing more patients to benefit from the most promising approaches. In…
UC San Francisco researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes. Replacing these cells, which are lost in patients with T1 diabetes, has long been a dream of regenerative medicine, but until now scientists had not been able to figure out how to produce cells in a…
A patient at the Queen Elizabeth Hospital Birmingham (QEHB) was the first person in the world to take part in a pioneering gene therapy trial for Ornithine Transcarbamylase (OTC) deficiency, a rare disease that causes toxic levels of ammonia to build up in the blood. Simon Smith, 45, was diagnosed with OTC deficiency as a teenager. Although he defied medical expectations by living a full life in…
When Olivia Nelson was 3 years old, her parents noticed that she had a fever that wouldn’t get better. They brought her to a nearby hospital, where she spent about two weeks being screened for diseases. As doctors tried to find a diagnosis, a lymph node on Olivia’s neck became swollen. Alarmed and wanting an answer, the Nelsons asked to transfer to Seattle Children’s. “It was very…
People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP)…
Mariette Barbier, an assistant professor in the West Virginia University School of Medicine, and her research team are investigating ways to keep cystic fibrosis patients and other at-risk populations—including patients hospitalized for severe burns or recovering from major surgery—from catching this deadly illness.
Communicating radiation risks is not only a legal requirement, it is also a moral obligation, asserts Dr Shane J Foley, radiographer and assistant professor at the UCD School of Medicine in Dublin, Ireland. Passing on radiation information has its pitfalls, but several helpful tools can improve communication, some of which the expert highlighted during ECR 2018.
Hypotrichosis simplex leads to progressive hair loss already in childhood. A team of researchers led by human geneticists at the University Hospital of Bonn has now deciphered a new gene that is responsible for this rare form of hair loss. Changes in the LSS gene lead to impairment of an important enzyme that has a crucial function in cholesterol metabolism. The scientists now present their…
As in many other countries, Belgium faces a significant shortage of health professionals – particularly pathologists to guarantee the diagnostic quality necessary for adequate therapeutic choice. A digital pathology platform can be a true ally; the Brussels Erasmus Hospital opted for that solution. Project manager Dr Ali Ramadhan shared his experience – the good, the bad and the ugly – at…
Scientists have uncovered the cause of Saul-Wilson syndrome: A single, spontaneous gene change alters protein packaging in the cell’s Golgi complex, causing the disease.
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids.
A pioneering study into myeloma, a rare cancer, could lead to General Practicianer (GPs) using simple blood tests to improve early diagnosis. The study investigated the best combination of blood tests that could be used to diagnose myeloma in GP practices.
Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy and affects more than two million people worldwide. In Germany, at least 30.000 people suffer from CMT which belongs to the class of rare disease. In a close collaboration, researchers at the Max-Planck-Institute for Experimental Medicine and the University Medical Center of Göttingen now hope to use lecithin, a harmless…
Imagine a pathogen that infects completely healthy people and can cause blindness in one day and flesh-eating infections, brain abscesses and death in just a few days. Now imagine that this pathogen is also resistant to all antibiotics.
Machine learning is adding a new dimension to pathology and already outperforming experts during some tasks, according to several speakers at the 14th European Congress on Digital Pathology (ECDP) who revealed up-to-date developments. However, whilst AI is set to herald a new future for digital pathology, Johan Lundin, associated professor for biomedical informatics and research director at the…
FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy.
While treatments for HIV mean that the disease is no longer largely fatal, the world still lacks a true therapy that can eradicate the virus across a globally—and genetically different—population.
People who consume an egg a day could significantly reduce their risk of cardiovascular diseases compared with eating no eggs, suggests a study carried out in China, published in the journal Heart. Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, including China, mostly due to ischaemic heart disease and stroke (including both haemorrhagic and ischaemic…
Pediatric researchers have found that children and adults treated with some oral antibiotics have a significantly higher risk of developing kidney stones. This is the first time that these medicines have been linked to this condition. The strongest risks appeared at younger ages and among patients most recently exposed to antibiotics. “The overall prevalence of kidney stones has risen by 70…
Two major projects feeding on big data and based in Spain have recently come under the spotlight: Mendelian, a tool to expedite rare diseases diagnosis, and Harmony, an EU platform that aims to improve targeted therapy in haematological cancer. Rare diseases affect as many as 6% of the Spanish population. Although this percentage is high, these conditions are individually rare, which complicates…
A far-reaching study conducted by scientists at Cincinnati Children’s reports that the Epstein-Barr virus (EBV)—best known for causing mononucleosis—also increases the risks for some people of developing seven other major diseases.
Gadolinium-containing/gadolinium-based contrast agents (GCCAs/GBCAs) and their usage was a major topic at ECR 2018. Fuelled by the current debate a number of presentations focused on possible impact, risks and necessities. Some were highly specific, others took a broader view. The only consensus, however, seems to be the need for more research and the focus on safety. Three ECR speakers, Joseph…
Jan Walker, a retired administrative assistant to the superintendent of Boaz City Schools, was getting ready for her regular doctor visit and noticed a lump on her neck. Her primary care physician examined it and determined it was a simple swollen lymph node. Two months later, she began to lose feeling on the right side of her throat and noticed the lump had increased in size. After seeing other…
The recent ACC/AHA Guidelines have increased the number of patients said to have hypertension by up to 40 percent (new 130/80 mmHg). The international recommendation is to treat hypertension with angiotensin converting enzyme inhibitors (ACEIs). These drugs, however, have significant adverse effects: Often a chronic dry cough leads to patients withdrawing from treatment. On rare occasions, ACEIs…
Together with three other neuroscientists Professor Christian Haass, speaker of the German Center for Neurodegenerative Diseases (DZNE) Munich site and Professor at the Ludwig-Maximilians-University of Munich, receives the world’s most valuable prize for brain research. The 2018 Brain Prize, awarded by the Lundbeck Foundation in Denmark, is worth one million Euros. Awarded annually, it…
People who are frequently exposed to diesel exhaust while on the job may have a higher risk of amyotrophic lateral sclerosis (ALS), and that risk may increase with greater exposure, according to a preliminary study released that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. “There is some suggestion from previous studies of…
To date, examining patient tissue samples has meant cutting them into thin slices for histological analysis. This might now be set to change – thanks to a new staining method devised by an interdisciplinary team from the Technical University of Munich (TUM). This allows specialists to investigate three-dimensional tissue samples using the Nano-CT system also recently developed at TUM. Tissue…
The television drama, Grey’s Anatomy, may be giving viewers a false impression of the realities of trauma care, including the speed at which patients recover after sustaining serious injuries, finds research published in the online journal Trauma Surgery & Acute Care Open. Unrealistic expectations of healthcare may be important in an era in which patient satisfaction is a key component of…
Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart. The Phase I study is part of a multi-center collaboration dedicated to employing innovative therapies to improve outcomes for children…
In April 2016 CEUS received the USA’s FDA approval. This year‘s RSNA Samsung Symposium ‘Contrast-Enhanced Ultrasound (CEUS): Innovations and a Problem-Solving Tool in Clinical Practice’ provided an opportunity to take stock. For European Hospital, Professor André Clevert, Director of the Interdisciplinary Centre for Ultrasound at University Hospital Munich, Germany, describes the current…
Respiratory infections peak during the winter months, and most people recover within a few weeks. But for those with a rare genetic lung disease, the sniffling, coughing and congestion never end. The tiny hairlike structures called cilia that normally sweep mucus through the airways don’t work properly in people with what’s known as primary ciliary dyskinesia. When the cilia don’t brush…
A new Michigan State University study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer. The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.…
Although targeted therapies have produced dramatic advances in our ability to control some types of advanced lung cancer, growth of the disease in the brain remains a major problem. Radiation is often used to treat deposits in the brain, but the best technique to deliver radiation can be controversial. Whole-brain radiation therapy, as its name suggest, treats the entire brain but can be…
Lars Schimmöller MD, associate professor of radiology at Düsseldorf University Hospital, tackled current diagnosis of prostate cancer (PCa) and addressed tumour detection, staging, active surveillance and recurrence during the Medica Academy session on Imaging Update. He also highlighted how MRI helps improve biopsies and avoid unnecessary surgery in PCa.
Managing diabetes and high blood pressure can feel like a solitary enterprise dependent on relationships with objects (like pills or foods) and activities (like brisk walks or early bedtimes) instead of relationships with people, but a group of West Virginia University researchers is hoping to change that. The National Institutes of Health has awarded $450,000 to Ranjita Misra, a professor of…
Liver disease is widespread in Germany. It is, in fact, the most common cause of death in patients under the age of 40, with liver cirrhosis, which can develop into liver cancer, playing a major role here. These days, modern, comprehensive treatment concepts are unimaginable without interventional radiology, for liver cirrhosis as well as liver cancer. Prof. Dr. Christian Stroszczynski, Director…
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published in Cell Host and Microbe, a scientific team led by the University of Wisconsin–Madison has identified signatures of Ebola virus disease that may aid in future treatment efforts. Conducting a sweeping analysis of everything from enzymes to lipids to immune-system-associated molecules,…
Artificial Intelligence (AI) has enormous potential to revolutionise the delivery of healthcare, being able to remove the drudgery’ of routine tasks, join up fragmented care records, trigger alerts when abnormal results occur, speed-up the process of identifying clusters of patients by digging deep into electronic health records, and increase efficiency of healthcare staff resources.
Artificial intelligence (AI) has taken centre stage during the Medica Academy sessions. While talks focus on initiatives made in Germany, European Hospital took a look at Spain and spoke with Ignacio Hernández Medrano, a neurologist recently elected as one of the most influential people in healthcare (HC). At just 34 years old, Medrano has already founded two flagship AI projects, one of which…
During our European Hospital interview with specialist in microbiology, virology and infection epidemiology Beniam Ghebremedhin MD, from the University Hospital Wuppertal, spoke about the impact of migration on infections, and ways to tackle the problem of multiresistant pathogens. ‘There is a lack of specialists in infectious diseases, for direct patient care on hospital wards as well as in…
Patients with advanced breast cancer have a better quality of life for longer if the progression of their disease can be delayed, according to new results presented at the Advanced Breast Cancer Fourth International Consensus Conference (ABC 4) in Lisbon. Professor Nadia Harbeck, head of the Breast Cancer Centre at the University of Munich (Germany), told the meeting that analysis of results from…
Until now, familial breast cancer has only partly been linkable to genetic risk markers. In a worldwide joint effort, researchers have now identified further genetic variants that affect the risk for breast cancer. The study, which was conducted with participation of researchers from the German Cancer Research Center (DKFZ) and Heidelberg University Hospital, has now been published in Nature.…
Heart surgery significantly decreases in-hospital mortality among infants with either of two genetic disorders that cause severe physical and intellectual disabilities, according to a new study by a researcher at the Stanford University School of Medicine and his colleagues at the University of Arkansas for Medical Sciences. Trisomy 13 and 18, which result from having extra chromosomes, often…
Acknowledging the need for faster ultrasound automation, Dr Alexander Weichert explained how automated procedures can assist in the early detection of cardiovascular disease and prenatal diagnostic testing, and why a detailed prenatal diagnosis can reduce mortality and morbidity.
Certain members of Generation Y, who grew up alongside enormous information technology (IT) advances, now occupy decision-making roles. Meanwhile, generation Z is emerging into the continuing IT revolution; the digital world surrounds us.
A Spanish team has, for the first time, successfully placed a pulmonary valve using catheterisation through the hepatic vein in a paediatric patient. Specialists believe this type of intervention could become an interesting alternative when traditional access points are not available.
Every cancer is different and every patient is different. This insight gained in personalised medicine prompted oncology researchers to focus more on the individual patient’s immune system. It is particularly the immune system’s ability to destroy cancer cells that raised hope.
Computer scientist Stefanie Speidel, who became a Professor for Translational Surgical Oncology at the National Centre for Tumour Diseases, in Dresden in Germany this April, researches intelligent assistance systems for the operating theatre.
With MEDICA 2017 drawing ever nearer, Joachim Schäfer, Managing Director of Messe Düsseldorf GmbH, sets the stage with the following statement:
Although dementia is most often seen in adults, childhood or adolescent dementia does occur. A team of researchers from the University of Würzburg believes that established therapeutic drugs might be effective against childhood dementia.
A major 20-year study provides further evidence that prostate cancer surgery offers negligible benefits to many men with early-stage disease. In such men, who account for most cases of newly diagnosed prostate cancer, surgery did not prolong life and often caused serious complications such as infection, urinary incontinence and erectile dysfunction.
Pancreatic cancer is one of the most deadly types of malignancies, with a 5-year survival rate after late diagnosis of only about 5%. The majority of patients—about 80%—receive their diagnosis too late for surgery. The disease spreads quickly and resists chemotherapy. In short, there is an urgent need for diagnostic tools to identify this cancer in its earliest stages.
Summer colds might seem rare, but people are actually just as likely to catch one in the summer as in the winter.
While new agents to fight virulent pathogens are in the pipeline, a new study pinpoints where a recent addition is already being applied in the clinic.
Oxford Gene Technology (OGT), The Molecular Genetics Company, today announced that it has signed an agreement to be acquired by Sysmex Corporation, a Japanese in vitro diagnostic company.
Spanish researchers are challenging the validity of many past and ongoing clinical trials and stress the importance of working with raw or preprocessed data in genetic information study.
A novel treatment offers kidney failure and kidney transplant patients with a rare disorder new hope. The treatment allows targeted elimination of plasma cell clones producing abnormal proteins that deposits in the kidneys and leads to kidney failure, according to new research.
New research further illuminates the surprising relationship between blood sugar and brain tumors and could begin to shed light on how certain cancers develop. While many cancers are more common among those with diabetes, cancerous brain tumors called gliomas are less common among those with elevated blood sugar and diabetes, a study from The Ohio State University has found. The discovery builds…
European Hospital reports a new approach in molecular diagnostics introduced during the IASLC World Conference in Vienna.
An international research team from the University Hospital of Munich (LMU), Newcastle University and the University of Liverpool has identified a gene mutation that causes a hereditary skeletal muscle disorder. The study is published in the "American Journal of Human Genetics".
Dr Ralf Doyscher, from the Department of Sports Medicine at Charité – Universitätsmedizin Berlin, has a close association with soccer at both professional and amateur levels. He recently participated in a scientific project focusing on preventative check-ups for the general health of elite young soccer players, and took the opportunity to simultaneously investigate the potential of…
Penn Medicine today launched its first Apple ResearchKit app, focused on patients with sarcoidosis, an inflammatory condition that can affect the lungs, skin, eyes, heart, brain, and other organs. The effort marks Penn’s first time using modules from Apple’s ResearchKit framework, as part of the institution’s focus on mobile health and innovative research strategies.
Genetics stepping ahead as Spain-based researchers develop biomedical robots that can help in the study of rare diseases, neurodegenerative disorders and cancer, as well as the creation of orphan drugs.
Up to ten years ago only a handful of antibodies that could be detected in the blood were known to neurology.
Professor Hans Clevers, researcher and group leader at the Hubrecht Institute in Utrecht, the Netherlands, invented the organoids, a ground-breaking new technique to grow new ‘organs’ and to test medication.
Scientists at Washington University School of Medicine in St. Louis have detailed the structure of a molecule that has been implicated in Alzheimer’s disease. Knowing the shape of the molecule — and how that shape may be disrupted by certain genetic mutations — can help in understanding how Alzheimer’s and other neurodegenerative diseases develop and how to prevent and treat them.
The ability to digitise results from patient samples has been one of the key enabling technologies that make personalised medicine possible now, says Dr Fiona Carragher, the Deputy Chief Scientific Officer for NHS England.
Multidrug-resistant tuberculosis (MDR-TB) is widespread globally, with an estimated 480,000 cases in 2014.Although rare in European countries, the risks posed by the current migrant crisis makes MDR-TB an important and urgent public health priority.
Wearable monitoring devices are offering patients the chance to play a greater and more active role in their own healthcare. They are alerting physicians and carers when a patient may be unwell, or their condition needs closely monitoring, and they have potential to improve the accuracy of findings within clinical trials. Report: Mark Nicholls
In Europe, the first baby with Zika-related microcephaly was born in July. The mother had contracted the Zika virus while travelling in America. How dangerous is the virus for Europeans, particularly since many visited Brazil for the Olympic Games in Rio?
Our knowledge of causes and mechanisms of current and future diseases is on ice – not the perpetual ice of the polar caps but artificial ice. It is stored in biobanks at -80 to -160 °C.
Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's. Now, researchers at Johns Hopkins say they have pinpointed the protein at the end of that chain of events, one that delivers the fatal strike by carving up a cell's DNA. The find, they say, potentially…
Researchers have found that Zika virus can live in eyes and have identified genetic material from the virus in tears, according to a study from Washington University School of Medicine in St. Louis. The research, in mice, helps explain why some Zika patients develop eye disease, including a condition known as uveitis that can lead to permanent vision loss.
Healthcare and business professionals as well as scientists consider Big Data a promising technology to advance medical research and patient care. “Big Data analysis allows us to better tailor therapies based on the individual patient’s status, that is to implement personalized healthcare,” says Dominik Bertram, Development Manager at SAP and Head of the development field “Personalized…
Cardiologists have highlighted the importance of all imaging modalities – including echocardiography and cardiac CT – to evaluate prosthetic heart valves in a new series of recommendations. AF-patients who were admitted to an NHS hospital over the weekend faced a higher risk of dying over the next five years than others.
Stroke patients will first undergo a CT scan as they enter the hospital. Before any further imaging scan is carried out, the medical team must decide whether they need to intervene intra or extra cranially. ‘Imaging enables you to see which pathology you are dealing with and helps you select patients for either recanalisation or revascularisation or, in some cases, occlusion by embolisation,’…
3-D print technology is expanding to cardiology surgery and interventional procedures. Research is scarce in Europe but a group of Spain-based cardiologists are currently developing 3-D print models to assess their value in the heart.
Clinicians around the world have long suspected that bacteraemia due to Staphylococcus aureus has a worse outcome in women compared to men, but direct evidence has been elusive. A study just published confirms that significantly more women than men diagnosed with Staphylococcus aureus bacteraemia (SAB) – a blood infection of the common bacteria – die within 30 days.
Pediatric laboratory medicine plays a minor role in the large field of laboratory medicine. This may be due to the low incidence of rare diseases, which are a major task of pediatric medicine, but also to the small number of pediatric samples in routine laboratory medicine overall. Since most diagnostic laboratories do receive pediatric samples now and then, it is essential that there are primary…
Hospital-acquired Clostridium difficile infection (CDI) is on the rise. Symptoms range from non-typical mild diarrhoea that can develop into pseudomembranous colitis up to a toxic megacolon, which often leads to death.
Jens Hahn MD is an Internal Medicine and Intensive Care Specialist who works with the international, independent, medical humanitarian organisation Médecins Sans Frontières (MSF in English: Doctors Without Borders). Here he describes his work in Afghanistan and South Sudan, and the use of rapid diagnostic tests in the field.
Cancer researchers from the Würzburg University, in cooperation with the international Cancer Genome Atlas Research Network, have identified new genetic drivers of adrenal cancer. Würzburg was the center of coordination of the European scientists.
Scientists at the University of British Columbia and Vancouver Coastal Health have proven that multiple sclerosis (MS) can be caused by a single genetic mutation – a rare alteration in DNA that makes it very likely a person will develop the more devastating form of the neurological disease.
A team from the International School for Advanced Studies (SISSA) in Trieste has obtained very promising results by applying gene therapy to glioblastoma. Tests in vitro and in vivo on mice provided very clear-cut results, and modelling demonstrates that the treatment targets at least six different points of tumour metabolism. Gene therapy, a technique that selectively attacks a tumour, might…
Researchers have found that a combination of chemotherapy and modern radiotherapy can benefit patients with advanced nasopharyngeal cancer – a cancer that starts at the back of the nose. These cancers are very rare in the UK and so modern treatments had not been previously studied in patients with advanced disease.
Every year around a quarter of a million children worldwide die from sickle cell disease. In Germany around 3,000 people suffer from this rare inherited blood disorder.
It turns out that the type, how frequent, and where new mutations occur in the human genome depends on which DNA building blocks are nearby, found researchers from the Perelman School of Medicine at the University of Pennsylvania.
Andrea G. Rockall, Consultant Radiologist at the Royal Marsden Hospital and Visiting Professor of Radiology at Imperial College in London, delivered the prestigious Wilhelm Conrad Röntgen Honorary Lecture at ECR 2016 on ‘Imaging the invisible killer: towards personalisation of ovarian cancer care’.
Paediatric imaging is a subspecialty that uses a diverse range of imaging systems, from classical X-ray to ultrasound, CT and MR.
Interstitial lung diseases (ILD) are rare – yet they are far more difficult to diagnose and highly variable. Professor Julien Dinkel, consultant at the Institute of Clinical Radiology, Ludwig Maximilian University Hospital in Munich, deals with these rarities.
The refugee wave rolls on with no ebb in sight. For many, Germany remains their travel destination. In August and September alone, tens of thousands refugees arrived in Munich, presenting the Bavarian capital with a major challenge: How could the city provide initial medical care for everyone? While the German Asylum Procedure Act governs the appropriate procedures, in this unprecedented…
When the Ebola virus outbreak erupted in West Africa in 2014, children infected with the virus — particularly those under age 5 — faced overwhelming challenges. Not only was there a high death rate among young children infected with the disease, they often were isolated from their families, leaving them feeling distressed and without the intensive care they needed.
Post mortems are now rarely carried out within UK hospitals – according to a study that examined all acute NHS Trusts within England, NHS Boards in Scotland and Wales and Social Care Trusts in Northern Ireland, and found that the process has disappeared completely in around a quarter (23%) of NHS trusts. In 2013, the average autopsy rate (percentage of adult in-patient deaths that undergo…
"It's not everyday that one newly discovers parts of the human body," says Roy S. Chuck, MD, PhD, Chairman Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine.
A team of scientists from the University of Michigan Medical School shows that the genetic material in female (but not male) cells makes tiny amounts of a special genetic material called RNA to make one of the two X chromosomes silent. They call this RNA XistAR.
Researchers have shown that people with high blood pressure develop changes in their hearts even before symptoms appear. These changes are known to put people at risk of dying early, and the new work suggests it is possible for doctors to recognise such signs of heart disease earlier than they can today - by examining detailed images of the heart.
An international team of researchers, led by scientists at the National University of Singapore (NUS), has identified a protein that regulates the growth of neurons by transporting key metabolic enzymes to the tips of neural cells. Their findings open up new avenues for design of drugs for ataxia, a motor coordination disorder.
As new cardiac genetic testing panels become available, cardiologists have been warned not to lose sight of the importance of comprehensive clinical evaluation. While genetic testing is helping to identify more people at risk of inherited conditions, experts stress they are only part of the diagnostic toolkit.
The challenges and advantages of using echocardiography as an invaluable tool in the assessment of Hypertrophic Cardiomyopathy have been highlighted at a major UK cardiology conference.
A new study at the University of Haifa has used “big data” analytical methods to reveal the “social character” of genes – a phenomenon in certain diseases whereby genes operate jointly rather than independently. “The problem is that the possible number of combinations of different genes is enormous, and it is almost impossible to examine them all effectively and reliably,” the…
The field is neither tedious nor monotonous; it’s fascinating every day, Professor Katharina Rentsch emphasises, when explaining the need to attract students to this often overlooked but intreguing and varied discipline.
Blood clots often form when lipid-rich plaques on the inner surface of arteries rupture and platelets aggregate at the site of injury. LMU cardiologists have now compared the effects of two new platelet aggregation inhibitors.
It may come as a bit of a surprise to learn that bacteria have an immune system – in their case to fight off invasive viruses called phages. And like any immune system – from single-celled to human – the first challenge of the bacterial immune system is to detect the difference between “foreign” and “self.” This is far from simple, as viruses, bacteria and all other living things…
This article discusses examples of applications of genetic analyses in coagulation disorders and haematological and oncological diseases. Professor Christine Mannhalter highlights the impact changes have on the occurrence and severity of diseases and their influence on therapy response. Report: Christine Mannhalter
“I am very concerned about the impact that Angelina Jolie has on the media,” Walter Rocca, professor of epidemiology and neurology at the Mayo Clinic in Rochester, Minnesota, stated. He wasn’t hinting to Jolie’s acting choices or waifish silhouette, but to the confusion surrounding her decision to remove her ovaries to prevent ovarian cancer. By Mélisande Rouger
Research published in the Proceedings of the National Academy of Sciences (PNAS) demonstrates that technology invented by researchers at Oregon Health & Science University’s Casey Eye Institute can improve the clinical management of the leading causes of blindness. Optical coherence tomography (OCT) angiography could largely replace current dye-based angiography in the management of these…
She is a neuroradiologist, professor, researcher and now the Medical Director of the Department of Neuroradiology at Dresden University Hospital. Her objectives are ambitious – be it in patient care, research or teaching. Professor Jennifer Linn MD wants to increase the quality of care, drive breakthroughs in research, ignite enthusiasm in students for their future profession and last, but not…
Black Blood Imaging may not sound helpful – but it is. The MRI specialist can work with clearer contrasts and gain greater certainty in tumour diagnosis as well as the detection of inflammatory changes in tissue.
Blood transfusions are avital part of medical care and yet the subject raises questions. ‘Blood transfusion should be restricted’, according to Professor Anders Perner, from the Institute for Clinical Medicine, Rigshospitalet, Copenhagen. ‘Blood transfusion could be more liberal’, says Dr Yasser Sakr, Senior Physician at University Hospital Jena. Debating their opposing views at the ISCEM…
The ‘Robert Koch’ plane for medical evacuations (MedEvac) is the winged equivalent of a German hospital isolation ward. Within it, medics with viral haemorrhagic fever while working on the Ebola outbreak in West Africa, receive intensive medical care during any stages of the disease, while being evacuated. Report: Anja Behringer
Damage to the spinal cord rarely heals because the injured nerve cells fail to regenerate. The regrowth of their long nerve fibers is hindered by scar tissue and molecular processes inside the nerves. An international team of researchers led by DZNE scientists in Bonn now reports in Science that help might be on the way from an unexpected quarter: in animal studies, the cancer drug epothilone…
Findings of a recent study say that environmental stress is a major factor for DNA damage and therefore the reason for accelerated tissue aging and probably cancer. Good sleep prevents this DNA damage.
A limited survey of patients who died soon after being discharged from hospital found that almost a quarter had an undiagnosed co-morbidity with a potentially avoidable cause of death. Report: Frank Swain
Patients are no longer content to be passive recipients of medical care, and are instead taking a more active role in their treatment, says Kathy Oliver, Chair co-director of the International Brain Tumour Alliance (IBTA). Report: Frank Swain
Earlier this year a drug was launched that can cure hepatitis C without severe side effects in most patients. Whilst the treatment is fast, it is very expensive but does avoid liver cancer and thus makes liver transplants superfluous. This is only one of the many promising developments in hepatitis research that Dr Markus Cornberg of the Medical University Hanover will address at the Medica…
In May, the World Health Organisation (WHO) warned that bacterial infections might lead to an increasing number of deaths because new resistance mechanisms threaten our ability to treat common infectious diseases.
Sepsis kills around a hundred and thirty patients daily In Germany alone. This systemic disease is mostly caused by bacterial pathogens, and less frequently by fungal organisms or parasites. The delayed diagnoses result in high mortality. Professor Dr Frank M Brunkhorst of the Centre of Sepsis Control and Care (CSCC), at Jena University Hospital, Germany, is seeking strategies to combat such…
Imaging procedures are rarely used to diagnose and treat asthma – but this may well change in the future.
Sepsis kills around 130 patients daily In Germany alone. This systemic disease is mostly caused by bacterial pathogens, and less frequently by fungal organisms or parasites. Professor Dr Frank M Brunkhorst of the Centre of Sepsis Control and Care (CSCC), at Jena University Hospital, Germany, is seeking strategies to combat such scary figures.
In a study that began in a pair of infant siblings with a rare heart defect, Johns Hopkins researchers say they have identified a key molecular switch that regulates heart cell division and normally turns the process off around the time of birth. Their research, they report, could advance efforts to turn the process back on and regenerate heart tissue damaged by heart attacks or disease.
The multiple benefits of PET/CT are undisputed – one being the fact that radiopharmaceuticals, which are used at pico and nano levels – are not toxic.
How does spectral – or dual energy – imaging work? Very similar to red and green light used in black-and-white photography. A black-and-white camera provides information on the colours of the photographed objects: an object that is black under red light is actually green.
The insight that psychological, social and environmental conditions affect a person’s health is insufficiently considered in medical training and in the every-day diagnosis and treatment of patients.
Why is early detection of breast cancer so important? Professor Dr Walter Heindel, Director of the Institute of Clinical Radiology at University Hospital Münster, Germany, offers an unequivocal answer.
Healthcare is undergoing a major change set to offer a real prospect of far more genetically targeted treatments, according a leading human geneticist Sir John Burn, Professor of Clinical Genetics at Newcastle University, England.
Ageing populations, struggling healthcare systems, medical staff shortages, rising costs – all are well recognised. Thus telemedicine, dubbed the ‘gold rush of the 21st century’ earlier in the year by Jonathan D Linkous, CEO of the American Telemedicine Association (ATA), is gaining momentum.
Each year the case grows stronger for transcatheter aortic valve replacement (TAVI). And it is only six years since the procedure was introduced in Europe.
While clinical labs and lab IT solutions appear to be able to meet current requirements, biobanking presents a whole new world of challenges to data flows and IT systems. Report: Michael Reiter
With the effectiveness of ‘tumour board review’ in the USA questioned in a 2012 study published in the Journal of the National Cancer Institute, Mark Nicholls sought the opinion of UK-based consultant urological surgeon Ben Challacombe
Timothy Roberts, PhD, works in the middle of an epidemic. In the 20 years the researcher has studied autism, the diagnosis rate among children in the United States has risen from one in 1,000 to one in 88. No one is sure of the cause, how to prevent it, or how to treat it.
‘All human body cells contain the same DNA, but every type of cell – for example a muscle cell compared to that of a nerve – has a different gene expression pattern’, said Dr Sonja Stadler, speaking at the 2012 congress of DGKL (German Society for Clinical Chemistry).
Across the globe, up to 400 million people carry the hepatitis B virus, and more than 180 million – approximately 400,000 in France – are infected with the hepatitis C virus.
Arterial stiffness of the central human blood vessels leads to increased work for the heart and damages microstructures in the organs. However, measuring blood vessel elasticity inside the body is not that easy.
Simultaneous surgical successes open new perspectives for multiple transplants
In laboratory studies, scientists at the Johns Hopkins Kimmel Cancer Center have developed a way to personalize chemotherapy drug selection for cancer patients by using cell lines created from their own tumors.
‘We aim to develop an understanding of which novel research activities could bring benefits for patients,’ explained Professor Christof von Kalle, Director of the Department of Translational Oncology, NCT (German National Centre for Tumour Diseases) and the German Cancer Research Centre (DKFZ), speaking on translational activities during the New Cancer Targets gathering in Heidelberg this…
Can an anaesthetist treat a patient with heart failure (HF) without any specialist knowledge of cardiology? That was the question posed by Dr Florian Weis, from the Clinic of Anaesthesiology at the University Hospital of the Ludwig Maximilian University Munich, when lecturing on perioperative management of this patient group.
Since its creation three years ago, the French National Alliance for Health and Life Sciences (Aviesan) has proved its full worth in scientific coordination, Annick Chapoy reports from Paris
Individually customised drug therapies have been used for the last two years, particularly for cancer patients
Paediatric radiologists are facing very special challenges. For their small patients they have to be able to precisely assess the advantages and risks of the different imaging modalities and procedures.
An echocardiography system that conveniently slips into a coat pocket, this kind of miniature device is now commercially available. Portable ultrasound has been around for about a decade, but until recently the machines were about the size of a laptop rather than that of a smart-phone
Germany hopes for better research conditions as revision of the EU Clinical Trials Directive is nigh
The largest ever, worldwide AI patient survey data presented at the 15th Congress of the European NeuroEndocrine Association (ENEA), Vienna, Austria. 87% of secondary AI patients and 60% of primary AI patients reported that their condition affected quality of life.
The case-based approach holds considerable promise for medical science. In a way, it’s a return to the roots, since this approach was common at the dawn of modern medicine. A case serves as a narrative that can be explored interactively in order to draw a conclusion, determine a course of action, or debate issues in a realistic context. Spanish cardiac imaging consultant Dr Rafael Vidal Perez,…
More anatomy details, real-time visualisation of catheter movement, and reduced exposure – MRI has promising potential in rhythmology, explain Professor Matthias Gutberlet and PD Dr Christopher Piorkowski, at the Heart Centre, University Hospital Leipzig, Germany.
With few experts, we need to raise awareness among physicians and undertake research to upgrade our knowledge of this disease
Cancer specialists everywhere increasingly face new findings from molecular biology. Genetic profiling of tumours opens up entirely new perspectives on the disease. How to cope with and integrate new insights into cancer diagnosis and treatment was among key issues discussed at the 2nd European Forum on Oncology, held in Berlin this May
Will MRI become routine modality? Today, thoracic MRI is rarely performed in Europe. But this will change over the next decade, predicts Professor Hans-Ulrich Kauczor, Medical Director of the Radiology Clinic at University Hospital Heidelberg. He expects Germany to be at the forefront of this development because MRI technology, despite the high costs, is already widely used here and because CT…
So close yet so far away! A fitting description of many diagnostic examinations of heart and lungs. Modern imaging modalities allow these two neighbouring organs to be evaluated together, nevertheless it is rarely done.
Faster assay for targeted chemotherapy's success against deadly liver cancer saves lives, and could speed lifesaving switch to alternative drug therapies for well-known pancreatic cancer.
DIA Europe’s 2012 EuroMeeting in Copenhagen on Tuesday 27 March is the setting for the public launch of EUPATI – the European Patients’ Academy on Therapeutic Innovation. DIA Europe is a major partner in this IMI (Innovative Medicines Initiative) funded education programme that will significantly improve the European public’s understanding about the development of medicinal products.
The German Paediatric Heart Centre (DKHZ) is one of the largest of its kind in Europe. Over 25 years the centre has treated big and small patients with congenital heart defects, very now and then being faced with rare, individual cases that present very particular challenges. In any one year, consultant paediatric cardiologist Professor Martin Schneider MD encounters perhaps five such non-…
Participants at European Health Forum Gastein 2011 (EHFG) agreed: the tendency in Germany and Austria is to operate far too soon (particularly for hip, knee and disc surgery), and many surgical interventions are unnecessary, posing a particular and increasingly urgent problem especially in industrialised countries. Hans-Christian Pruszinsky reports
Xenon anaesthesia not only preserves the heart and circulation but also prevents post-operative delirium. The high cost of the gas is made up for by a shorter length of sta. Report: Holger Zorn
‘We are all aware of the importance of early diagnosis and rapid appropriate treatment of patients with severe sepsis. Yet, many patients still do not receive satisfactory early management and the application of recent guidelines for sepsis management is still inadequate,’ writes Jean-Louis Vincent MD PhD, from the Intensive Care Department, Erasme Hospital, Université Libre de Bruxelles,…
Patients and health care providers are increasingly crossing borders within the European Union to deliver or receive treatment. New EU regulations are trying to come to grips with what has long been recognised as a right of citizens to do so. Motivations vary among member states and social groups, but specialty treatment and speed of access are important factors. While cross border care is…
The European Society of Cardiology, through the European Chronic Disease Alliance (ECDA), has urged European heads of state "to show leadership" and long-term commitment to the prevention of chronic non-communicable diseases at today's "high level meeting" of the UN General Assembly in New York.
Uncontrollable convulsions, tremor or spasms can considerably impair the lives of neurodegenerative disease patients. Deep brain stimulation (DBS) – for which tiny electrodes are implanted in the brain to stimulate the target areas continuously with electrical impulses – can significantly reduce the movement disorder.
Too much unhealthy food, too little exercise – the risk factors for the development of non-alcoholic fatty liver disease and Type 2 diabetes are not only similar but also form a life-threatening alliance.
Adults with congenital heart failure (CHD) are a growing special subset of patients with specific needs; most need lifelong care, but in adulthood many fail to receive it. By Holger Zorn
Over the last 25 years overweight and obesity have become a global epidemic. According to WHO figures, at least 400 million adults are obese worldwide. Part of this phenomenon relates to lifestyle changes - lack of exercise, wrong eating habits - whereas genetic factors also play a role (according to twin studies, the determination of obesity is 70% nature and 30% nurture).
Royal Philips Electronics is announcing CE marking for the industry’s first commercially available whole body PET/MR imaging system, the Ingenuity TF PET/MR*. This new system, being launched as the first new Philips modality in ten years, integrates the molecular imaging capabilities of PET with the superior soft tissue contrast of MR to image disease cells as they proliferate in soft tissue.…
Who has not dreamed at least once to live in future times? Who would not want that one’s today incurable diseases may be cured in the future by medical progress? Long-time cryopreservation immediately after death is the betting ticket to that future.
Muscular diseases belong to a heterogeneous group with various causes like neurogenic, metabolic, dystrophic, or inflammatory mechanisms as well as channelopathies leading to disorders of the muscle cell membrane potential. In most progressive disease cases the result is a focal or general muscle weakness that, unfortunately, is a very unspecific symptom. Standard neuromuscular literature…
Small genetic differences between individuals help explain why some people have a higher risk than others for developing illnesses such as diabetes or cancer. In the journal Nature, the 1000 Genomes Project, an international public-private consortium, published the most comprehensive map of these genetic differences, called variations, estimated to contain approximately 95 percent of the genetic…
HEID or Health in Europe: Information and Data Interface is designed as a wikipedia for health and – at the moment in the test and pilot phase – enables everybody to find comparable European Health information and data free for use. Set up by the European Commission, DG Health and Consumers, the content is updated on voluntary basis by experts and health authorities, agencies and…
In the light of global climate change, the relations between weather and health are of increasing interest. A drop in the average temperature outside is linked to a higher risk of people having heart attacks, according to a new study published on bmj.com today. UK researchers found that each 1°C reduction in temperature on a single day is associated with around 200 extra heart attacks.
„Diseases of the nervous system and the brain occur more frequently than cancer. According to recent calculations of health care costs, they represent a burden of 386 billion euros a year on European economies,“ says Prof. Gérard Said, newly elected president of the European Neurological Society (ENS) at the annual meeting in Berlin, Germany. „This is often greatly underestimated.“
This year's European Congress for Orthopaedics, Orthopaedic Surgery and Traumatology, organised by the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) and which will in tandem with the Spanish Orthopaedic and Traumatology Society (SECOT) Congress, is expected to draw 7,500 international participants.
The Opening Lecture at ECR always draws immense attention. On March 4th, it was the “First Lady of Radiology” as Congress President M. Szczerbo-Trojanowska called her, Professor Dr Anne G. Osborn, University of Utah, USA, who opened the event. The internationally renowned doctor of diagnostic neuroradiology spoke about “The two faces of HIV/AIDS in the brain” – a matter close to her…
The European Congress of Radiology (ECR), the annual meeting of the European Society of Radiology (ESR), has started. We accpeted 505 lectures and 880 scientific papers from an all-time high of 5.657 submitted abstracts. It would not be fair to single out some individual topics, as Professor Christian J. Herold, ESR President and Chairman of the Department of Radiology at the Medical University…
Molecular imaging, a new science that emerged from molecular biology, is unlike traditional imaging. Whilst the latter can, for example, show the differences in proton density or water content on MRI, molecular imaging uses biomarkers (probes) that interact selectively with molecules within an area and then generate the image according to fine molecular alterations occurring inside (e.g. within a…
Anders Olauson, President of the European Patients’ Forum was awarded with H.M. The King's Medal at the Royal Palace in Stockholm. This prestigious award was presented to Anders for his distinguished commitment in the field of patients rights and his tremendous support for families with young patients in Sweden . The King’s Medal is the second highest award that can be received by a Swedish…
Like a bolt from the blue ischemic stroke strikes a patient unpredictably. The consequences are devastating: stroke is the number one cause of serious disabilities in adulthood - and, in Europe alone, someone suffers a stroke every 20 seconds. Thrombolysis ensures that blood clots in the brain dissolve. However, the majority of patients do not profit from this therapy.
Breast and cervical cancer together account for more than one quarter of all female cancer deaths worldwide, with the majority – including more than 85 % of all cervical cancer deaths – occurring in developing countries. However, a small number of highly effective programs demonstrate that much can be done to reduce risk and increase sustainable access to diagnosis and treatment for these…
A young singer leans against the mixing desk in a recording studio in a laid-back manner. She listens to songs just recorded for her new album, moving her lips to the sound. Suddenly she stops, reaches for her head and seconds later collapses, unconscious. On hospital admittance physicians discover that a previously undetected aneurysm in her brain has ruptured.
Two genes containing mutations known to cause rare familial forms of parkinsonism are also associated with the more common, sporadic form of the disease where there is no family history, researchers have found. An International study reveals common gene variants in people of European descent.
The "European Health Award" presented this year at the European Health Forum Gastein (EHFG) goes to the European Patient Assessment (EPA) project. EPA is designed to improve the exchange of knowledge and experience by practical physicians in the area of primary care. Cross-border healthcare initiatives are distinguished every year with the European Health Award.
600 international politicians, economists, scientists, NGOs and healthcare organisations will discuss the effects of the global economic crisis on European healthcare systems during this autumn's European Health Forum Gastein (EHFG).
Today, transcatheter aortic valve implantation (TAVI) represents an effective therapeutic alternative to conventional aortic valve replacement for patients who are at high risk or with contraindications to surgery, and the combination of the transfemoral and transapical approaches further increases the number of patients who can be treated.
A new study shows that a radioactive skin patch can safely and successfully treat basal cell carcinoma, one of the most common types of skin cancers, according to researchers from India. The skin patch, which delivers the radioactive phosphorus-32, is nontoxic and could be an excellent alternative to surgery or radiotherapy in cases where carrying out these treatments is difficult.
A paper of Professor Christiane K Kuhl and her colleagues had discovered that, to detect pre-invasive breast cancer (DCIS), the addition of high-resolution MRI and state-of-the-art mammography offered a significantly higher sensitivity compared with state-of-the-art mammography.
In a symposium organised by Bayer Schering Pharma at the 2009 European Congress of Radiology (ECR), the audience heard a series of four presentations on the potential advantages of high-signal-intensity contrast agents for MRI, focusing on gadobutrol (Gadovist). During the discussion, several claims made by the speakers were challenged and debated by ECR delegates.
Big discussions are expected at the upcoming European Association of Urology (EAU) Congress in Stockholm* when urologist Dr Jochen Walz (right), of the Urological Department at the Institute Paoli-Calmettes, Marseilles, France, presents the forum: Imaging in Europe: Who, where, what, how many! and M F Coelho, of the European Society of Urological Imaging (ESUI) describes the Clinical utility of…
Due to significant developments in ultrasound contrast media and equipment technology even the finest blood vessels can be visible through contrast-enhanced sonography.
Specialists at the Imperial College Healthcare NHS Trust, in London, have started using pioneering laser surgery to treat patients with pathological eye conditions, such as superficial corneal scarring.
Christian Pruszinsky reports from the 11th European Health Forum Gastein in Austria: `Achieving the level of healthcare of the older EU member states will remain a long-term project for new members´ .
Last week, the Commissioner for Health, Androulla Vassiliou launched the 'Europe for Patients' campaign in Brussels. The campaign highlights the different health policy initiatives the Commission intends to adopt in the coming months. All these initiatives are bound by a common goal: better healthcare for all in Europe.
Approximately 31 million people in the European Union are suffering from diabetes, a devastating disease with severe consequences for patients and their families, but also for the society at large and the economic prosperity of Europe. This week EH Online will focus on innovative strategies in diabetes care and on new management systems to support physicians and patients alike. Moreover, we will…
The BACH (Biomarkers in Acute Congestive Heart Failure) trail, an international, multi-marker study, analysed the diagnostic and prognostic precision of new biomarkers in patients with dyspnea (Shortness of Breath).
The programme for this year's European Health Forum Gastein (EHFG) - its 10th gathering - covers a far broader range of topics than before. During over 20 plenary sessions, forums and workshops, with about 120 lectures, key topics that embrace European and the national health politics of EU member states will be presented and discussed by experts.
The diagnostic work-up of syncope patients often raises the question of how much diagnosis is necessary and what examination methods are really needed. To save time, specialists recommend focusing on determining whether the syncope may be caused by a cardiac problem - a question answered quite easily in many cases. Karl Eberius MD, European Hospital's new correspondent, discussed advice for…
Almost 25 years ago Michael Harrison of the University of California, San Francisco (UCSF) operated on the bladder of an unborn child. Almost eight years later, surgery was carried out on the diaphragm of an unborn child. His approach was controversial: a paediatric surgeon opened the abdomen and uterus of the pregnant woman, lifted out the foetus, performed the surgery and returned the foetus to…
Since decades women carefully feel their breast. Hoping that they will not find any evidence for lumps or other changes, that might signal breast cancer. However, a review of recent studies conclude that self-exams do not appear to reduce deaths. Whereas radiation therapy may lower recurrence rate of rare breast cancer.
The Cardiomobile developed by the Institute of Health and Biomedical Innovation at Queensland University, Australia, contains a Mini ECG and a GPS system linked to a mobile phone via Bluetooth. That way heart patients can do rehabilitation exercises any place and any time they want to.
A research team at Cedars-Sinai Medical Center, the University of Texas Medical Branch and RWTH Aachen University in Germany has developed a new classification system devised to guide physicians treating patients with symptomatic myocardial bridging, published in the online edition of Cardiology.
Physiology is the science concerned with the processes and functions of an organism.
For the 15th time in a row General Electric (GE) Healthcare's Innovation Award for radiological diagnostic imaging was presented. This year's two recipients - Dr Isabelle Naßenstein of the Institute of Clinical Radiology at University Hospital Münster and PD Dr Ulrike Wedegärtner of the Diagnostics Center of University Hospital Hamburg-Eppendorf (UKE) — share the 15,000 EUR prize money.
Every three minutes, two people living in India die of tuberculosis. This equates to approximately 370,000 deaths each year, and a staggering economic toll: an estimated US$300 million in direct costs and US$3 billion in indirect costs.
Developments in MRI over the last few years have revolutionized the diagnosis and therapy of cardiovascular diseases. Contrast-enhanced MR angiography has established itself as a non-invasive, standard procedure for the diagnosis of vascular diseases in the thorax, abdomen and periphery.
Gastric polyps (GP) are typically found incidentally, when upper gastrointestinal (GI) endoscopy is performed for an unrelated indication. Gastric polyps are uncommon and have an incidence of less than one percent. Only rarely do they cause symptoms or other clinical signs.
Before discussing a possible connection between gadolinium and nephrogenic systemic fibrosis (NSF), Dr Herborn offered a brief background:
'How do you treat the HIV-positive, diabetic, schizophrenic patient presenting with chest pain? By making the necessary information available for personalised medicine'
Andrea Martini and Joerg Larsen, of the Institute for Roentgendiagnostics, Braunschweig Teaching Hospitals, Germany, discuss nanotechnology, hybrid imaging and the quest for a personalised medicine.
Biotechnologist Dr Jens Meiler explains his reasons for emigration to America
Czech Republic - The second successful hemicorporectomy (translumbar amputation) was carried out several months ago by surgeon Frantisek Antos and team at the Bulovka Faculty Hospital, Prague.
In the heart of Paris, the Necker children's hospital, the oldest in the world dedicated to paediatrics, was suffocating inside a completely inward-looking enclave. The challenge was to achieve a vast upheaval to overcome the hospital's lack of relationship with its surroundings and open it onto the city, while also carrying out an in-depth metamorphosis to adapt it to new requirements.
A Swiss-German research team under the supervision of Dr. Dr. Frank Rühli of the Institute of Anatomy, University of Zurich, Switzerland, reports a milestone in medico-diagnostic research of ancient mummies. For the first time ever worldwide, high-quality images of intact historic mummies were achieved through magnetic resonance imaging (MRI) without prior destructive rehydration of the…
Children with recessive dystrophic epidermolysis bulosa (RDEB) lack a protein that binds the skin to the body, resulting in fragile skin that sloughs off with little movement or friction.
Radiologist Dr Myriam Hunink is a Professor in the Epidemiology and Biostatistics and the Radiology Departments at the Erasmus MC in the university medical centre, Rotterdam, the Netherlands, where she is also project leader for several research projects focused on radiology and epidemiology.
Diabetic foot syndrome (DFS) is one of the most serious sequela of diabetes mellitus - Disease management programmes (DMP) yield first results
The rare disease Takayasu's arteritis (TA) belongs to the vasculitis group of diseases and is also known as inflammatory aortic arch syndrome or as pulseless disease because of its typical clinical picture. The pathological-anatomical manifestations include inflammatory transformation of the media and adventitia with the appearance of giant cells, hence the term giant cell arteritis is also used.…
The interest in using traditional Chinese medicine (TCM) alongside conventional Western medical care has steadily increased among European physicians; it is no longer unusual, for example, for acupuncture to be suggested by a doctor to help fight tobacco addiction, or to ease a persistent musculoskeletal problem.
Already in 1993, the world market for contrast media was thought to be worth $ 3 billion. In 2001, an astonishing 12.2 million contrast medium-supported CT studies were carried out in Europe alone. Currently, the overall sales of contrast media are estimated to rise to $ 915 million in Europe in 2008.
Dr A Tamosiunas, Associate Professor at the Radiology Centre in the Medical Faculty at Vilnius University, Lithuania, and Director of the Radiology Centre at Vilnius University Hospital, discusses the present situation and future development of the radiology services in Lithuania with EH correspondent Andrius Vagoras
TREAT-NMD (Transnational Research in Europe - Assessment and Treatment of Neuromuscular Diseases) is a European Union funded Network of Excellence launched on January 1st 2007 with the aim of improving treatment and finding cures for patients with neuromuscular diseases.
The Helios group of hospitals recently introduced a new scheme for a unified, comparable set of indicators to describe the most important services and quality parameters in hospitals. The model is a trend-setting step towards greater transparency - with less administrative effort.
A “political agreement” on the EU Health Programme 2007-2013 recently has reached the Health Ministers Council in Brussels. The programme is a framework for the Commission´s funding of projects relating to health and will be part of a broader EU health strategy to be put forward by the Commission next year.
The EHFG has developed into the leading health policy platform in the EU since its beginnings in 1998, attracting close to 600 high-level participants annually.
At the 11th International MR Symposium radiologists were urged to co-ordinate a campaign to detect disease earlier, and a new 'tandem' concept for diagnosis and therapy was revealed.
Dr Christiane Eickelberg, of the University of Giessen Lung Centre (UGLC), outlines the centre's research projects, aims and academic offerings
Experts call for screening of surgical and medical patients, and thromboprophylaxis for those at risk.
Article by Stefan G Ruehm MD, Associate Professor of Radiology, Director, Cardiovascular CT, at the David Geffen School of Medicine, UCLA.
Five years of therapy with the drug tamoxifen has become the norm for postmenopausal women with hormone-sensitive breast cancer. However, this has several adverse side effects, and studies have continued to compare the effects of other drug therapies with tamoxifen.