Digital mammography (MLO) without suspicous findings (BIRADS-2) in low...
Digital mammography (MLO) without suspicous findings (BIRADS-2) in low intermediate dense breast (ACR-3/D)

Article • Alternative for mammography

Breast cancer screening: Does the future belong to the abbreviated MRI?

Is mammography still the best method for breast cancer screening? For a number of breast cancers, the latest scientific findings suggest otherwise. For more than a decade, Professor Christiane Kuhl MD, Director of the Clinic for Diagnostic and Interventional Radiology at the University Hospital RWTH Aachen, has researched the use of MRI in breast cancer screening. During a Bayer Healthcare webinar at the RÖKO Digital Congress the radiologist explained why she believes abbreviated MRI protocols to be a game changer which could, in fact, completely replace mammography for screening.

Report: Karoline Laarmann

portrait of christiane kuhl
Professor Christiane Kuhl MD is Director of the Clinic for Diagnostic and Interventional Radiology at the University Hospital RWTH Aachen, Germany

Despite its overall success, mammography screening also continues to attract criticism. For one, it detects breast cancers which are prognostically irrelevant, resulting in overdiagnosis. Mammography also does not detect all breast cancers that are of prognostic relevance, thus underdiagnosing cases. “20-30% of breast cancers detected in women who participate in screening are not discovered during mammography screening but during the intervals,’ Professor Kuhl points out. ‘These interval cancers are basically nothing other than cases of failed early detection of fast-growing, and therefore prognostically relevant, breast cancers.’

The reason for underdiagnosis not only lies in the density of the glandular breast tissue but also in the tumour biology. As the detection of breast cancer in the mammography- or digital breast tomosynthesis image is based on the visualisation of architectural distortion, microcalcification or spiculated mass, it is particularly suitable to find luminal, i.e. less aggressive breast cancers, whilst biologically aggressive tumour types can appear in X-ray based images as ubiquitous, benign changes, such as cysts or fibroadenomas.

Digital mammography (CC) without suspicous findings (BIRADS-2) in low...
Digital mammography (CC) without suspicous findings (BIRADS-2) in low intermediate dense breast (ACR-3/D)

Improving prognosis with MRI

‘We need a method for early detection which offers a sensitivity profile that meets the oncological demand and finds those cancers that are prognostically relevant,’ Kuhl demands. In 2010, the professor of radiology already proved that MRI meets these criteria with the results of her multicentric EVA-Study. This compared the efficiency of different imaging procedures for breast cancer screening in women with increased risk in the family. 

The study showed that MRI had the highest hit rate for tumours detected, and the interval cancer rate was zero.Kuhl presents a simple explanation: ‘When we use MRI for breast cancer screening and use contrast medium, we do nothing other than visualising the angiogenesis and protease activity – tissue changes that directly correlate with carcinogenesis, cell proliferation and metastatic growth. This basically means that MRI is at the other end of the sensitivity spectrum compared to mammography. Or, put differently: the more biologically aggressive the breast cancer the more reliably it is detected with MRI.’

MIP of abbreviated MRI: highly suspicous findings on the left
MIP of abbreviated MRI: highly suspicous findings on the left

Fast and effective: Abbreviated MRI protocols

The reason that MRI is still rarely used for early screening, i.e. only for women with a high-risk profile, is mainly due to high cost and lack of availability. An abbreviated version of MRI, focusing on the essentials, can now provide relief. Kuhl and her team have developed a protocol which only consists of subtracted images acquired before and after the administration of contrast medium (FAST), which are fused into a projection image with maximum intensity (MIP). The results, first published in a study in 2014, astounded even Kuhl herself. 

The diagnostic precision of the abbreviated MRI protocol was equivalent to that of the complete MRI protocol and was no less sensitive and specific. Furthermore, not only was the examination time short (three minutes) but so was the average time an experienced radiologist needed to determine whether breast cancer was present or not (2.8 seconds), and characterising an enhancement in an image also only took 28 seconds.

FAST (first post contrast subracted) (= single-slice): MR-BIRADS-5
FAST (first post contrast subracted) (= single-slice): MR-BIRADS-5

More than just an add-on – it works

Since then, many further international studies on the subject of abbreviated MRI protocols versus complete MRI protocol have been carried out, with all of them coming to the same conclusion: Abbreviated MRI protocol for screening works. But, does it work as a standalone tool for breast cancer screening? This question was examined in a study published in 2020 which compared abbreviated breast MRI protocols with DBT in women with dense glandular breast tissue. Both methods were used independent of one another. 

It was found that the detection rate for invasive cancer for abbreviated breast MRI protocols was significantly higher than for DBT, i.e. 11.8 per 1,000 women vs 4.8 per 1,000 women. For Kuhl, the data means one thing: ‘Abbreviated MRI protocols are not only an add-on method but a standalone solution that is superior to all other screening methods, independent of the individual risk of developing the disease.’


Prof Dr Christiane Kuhl has directed the Clinic for Diagnostic and Interventional Radiology at the University Hospital Aachen since 2010. Kuhl studied medicine in Bonn, the city of her birth (1966) and, in 2004, accepted a C3 professorship at the Department for Oncological Diagnostics and Interventional Radiology at the University Hospital of Bonn. Today, she is considered to be among the most renowned German breast cancer researchers. Her work has received numerous awards nationally and internationally. From her experience, Kuhl advocates the use of MRI for early breast cancer detection.


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