Baby Jasmine was born in late December with hypoplastic left heart syndrome...
Baby Jasmine was born in late December with hypoplastic left heart syndrome (HLHS) and had her first open-heart surgery at five days old. She is enrolled in the groundbreaking clinical trial at Children’s Hospital Los Angeles.
Credit: Children’s Hospital Los Angeles

Hypoplastic left heart syndrome (HLHS)

Stem cells might be the key to treating rare cardiac defect

Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart.

The Phase I study is part of a multi-center collaboration dedicated to employing innovative therapies to improve outcomes for children with hypoplastic left heart syndrome (HLHS), a congenital heart defect in which the left ventricle is severely underdeveloped. The HLHS Consortium, launched at the Mayo Clinic in Minnesota in 2017, involves four regional centers. CHLA, the only West Coast member, makes the initiative bicoastal.

This is one of the earliest efforts at harnessing the power of stem cell technology for the care of children with a serious cardiac disease

Ram Kumar Subramanyan

"We're proud to be part of this select group of institutions," says Vaughn Starnes, MD, co-director of the Heart Institute at CHLA and chair, Department of Surgery, at the Keck School of Medicine of the University of Southern California. "As a leading center for medical and surgical treatments for HLHS, we want to be at the forefront of the next transformative therapy for treating this complex condition." In addition to the Mayo Clinic, other Consortium members include Children's Hospital of Philadelphia and Minnesota Children's Hospital. "It is very exciting that Children’s Hospital Los Angeles has joined the HLHS consortium. It means that individuals with HLHS now have more options when it comes to participating in groundbreaking clinical trials and other research," says Timothy Nelson, MD, PhD, director of the Mayo Clinic's Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome.

In HLHS, the left ventricle of the heart can't pump oxygen-rich blood from the lungs to the rest of the body. Without surgical intervention, HLHS is fatal. Children undergo a series of three surgeries in their first three years to make the right ventricle the heart's main pumping chamber and improve blood flow. This first-of-its-kind clinical trial combines pioneering surgical techniques with regenerative medicine. "This is one of the earliest efforts at harnessing the power of stem cell technology for the care of children with a serious cardiac disease," says Ram Kumar Subramanyan, MD, PhD, a cardiothoracic surgeon who is heading the HLHS study in CHLA's Heart Institute.

CHLA first performed HLHS surgery in 1992. In the decades since, doctors have found that as children with HLHS reach adolescence, their reconstructed hearts are deteriorating. For some, that means heart failure and the need for a heart transplant. "We are looking for novel approaches to this vexing problem," says Starnes. At the time of delivery, newborns enrolled in the study will have their umbilical cord blood collected and sent to the Mayo Clinic where the stem cells are removed. Within a few hours of birth, the baby arrives at CHLA and has the first HLHS surgery 2 to 5 days later.

The second open-heart surgery, the Glenn procedure, takes place at about six months of age, when the baby's own stem cells are injected back into their heart. The hypothesis is that stem cells will stimulate the heart muscle to grow during the critical first year of life, when cardiac cells still have the ability to proliferate. At about three years of age, the child then has the third surgery, the Fontan procedure.

All children in the study will be followed long-term, as doctors look for signs that their hypothesis is working to produce a stronger heart for these at-risk children. Together, the HLHS Consortium members hope to recruit about 20 children for the Phase I umbilical cord blood study. CHLA investigators already have enrolled several families. Find out more about the study at CHLA here.


Source: Childrens Hospital Los Angeles

05.02.2018

Read all latest stories

Related articles

Efferocytosis

Can stem cell exosome therapy reduce fatal heart disease in diabetes?

Macrophage cells routinely remove dead or dying cells to maintain the body homeostasis. Such removal becomes crucial after serious injury, especially the repair of dead heart muscle after a heart…

Mortality decrease

Newborns with trisomy 13 or 18 benefit from heart surgery

Heart surgery significantly decreases in-hospital mortality among infants with either of two genetic disorders that cause severe physical and intellectual disabilities, according to a new study by a…

Young at heart

Cardiac stem cells from young hearts could rejuvenate old hearts

Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from the Cedars-Sinai Heart Institute.

Related products

Research use only (RUO)

Eppendorf - Mastercycler nexus X2

Eppendorf AG

Research use only (RUO)

SARSTEDT - Low DNA Binding Micro Tubes

SARSTEDT AG & CO.

Research use only (RUO)

Shimadzu - CLAM-2000

Shimadzu Europa GmbH