AI-enabled spatial analysis can identify patterns in routine pathology slides that may help clinicians identify which patients with pancreatic cancer are at greater risk of recurrence after treatment and surgery, a new study finds.
Radiotherapy may be able to do far more than simply destroy tumor cells. A review explores how combining radiotherapy with immunotherapy could improve outcomes for patients with pancreatic cancer.
A new study shows that phage therapy could help reduce recurrent infections, which happen when the bacteria responsible for UTIs ‘hide’ in the tissue of the bladder.
In glioblastoma, the treatment order matters: a new study shows that administering cell immunotherapy before surgery to remove a brain tumour is significantly more effective than the other way around.
Exposure of the thymus to radiation during lung cancer treatment is linked to an increased risk of the cancer spreading to other parts of the body and overall worse outcomes, a new study finds.
Researchers have found an ‘immune organ’ inside the skull, which directs brain defenses. The findings may offer a new way to fight brain cancer and neurodegenerative diseases.
Digital pathology and spatial omics could enable researchers to see how a tumor's different cell populations function, opening new perspectives for precision cancer therapy.
The human norovirus is the leading cause of acute gastroenteritis worldwide, infecting 600–700 million people each year. A new study could help explain the high infectivity of the virus.
A new study has identified a way to reshape the gut microbiome that can enhance the delivery of certain chemotherapies to tumors, making these nanoparticle-based cancer drugs more effective.
Photothermal therapy to selectively destroy cancer cells shows promise as a much less invasive treatment option than surgery or radiation. Now, researchers cleared two major hurdles for the method.
Virus-associated molecules in the foot are enough to trigger the network: Research reveals a remarkable mechanism, in which the brain prepares for a potential viral attack within hours of infection.
Adenomyosis can cause heavy menstrual bleeding, severe pain, and pregnancy and fertility complications. New research could help pave the way for more targeted, less invasive treatments.
The microbes living in the human gut influence metabolism, immunity, and cardiovascular health. A new study now suggests they may also be closely connected to Alzheimer's disease.
Researchers have developed a new lab model to study BAP1-deficient melanomas, a rare type of melanoma that evade the immune system once they metastasize and are resistant to current immunotherapies.
A pilot study shows that immunotherapy may enable stimulation of egg maturation in women with premature menopause. Three out of ten women gave birth to healthy babies following the treatment.
A study from the University of Calgary shows that removing a single gene makes colon cancer cells a target for immunotherapy — a fundamental breakthrough.
AI is transforming the way cancer is diagnosed and treated. Dr Yuri Tolkach shared his group's advances in developing AI-based tools for oncological pathology at the DPAI Europe congress.
Prof. Johanna Joyce has begun her two-year term as President of the European Association for Cancer Research (EACR), a global community of scientists and clinicians dedicated to advancing the scientific understanding of cancer and its application to improve patient care.
At which point does Alzheimer’s disease pathology lead to dementia? Researchers identified distinct mechanisms in the brain, which could represent an important target for future therapies.
A novel PET imaging framework reveals that bariatric surgery impacts not only body weight, but also the metabolic function of organs. These insights could support more precise treatment monitoring.
A new approach to repair spinal cord injuries: A biohybrid robot combining therapeutic stem cells with magnetoelectric nanoparticles. First tests on zebrafish and mice show promise.
A hookworm can survive in the human gut for years. Researchers have now harnessed that biological mechanism, engineering a hookworm to produce and deliver a drug within a living host.
Obesity may change how early-stage breast cancer becomes invasive, according to a new study. The findings could help improve physicians’ ability to predict and treat the disease.
A simple, affordable urine test could detect early signs of lung cancer months, or even years, before symptoms appear, as well as monitor whether treatment is working and identify potential relapse.
A new study proposes a new antiviral strategy against SARS-CoV-2 based on a treatment that combines two complementary approaches, capable of attacking the virus simultaneously.
Researchers have reported results from a first-in-human trial evaluating a novel cell-based platform for localized delivery of interleukin-2 (IL-2) in patients with advanced ovarian cancer.
New research reveals that testosterone slows glioblastoma growth—the opposite of the androgen’s effect on tumors outside the brain.
A CRISPR-based tool called Cas12a2 can selectively eliminate cancer and virus-infected cells based on their RNA signature – with high precision and no off-target effects.
Now, a new study identified a gene therapy for individuals with cystic fibrosis (CF) caused by a specific mutation and for whom there was no treatment available until now.
A new technique to “prime” a patient's immune system before liver transplantation has proven itself in a first-in-human clinical trial to successfully prevent transplant rejection.
A multidisciplinary team of pathologists, oncologists and biologists has discovered a new biomarker to determine whether immunotherapy may work in people with colon and rectal cancer.
Scientists from the University of Maryland School of Medicine and colleagues create the first-ever immune-capable “Cervix-on-a-chip” to study sexually transmitted infections (STIs).
A new review shows that chronic stress may actively drive cancer progression. Therefore, psycho-oncology should be part of standard cancer care, the researchers argue.
People with multiple sclerosis (MS) now live significantly longer, thanks to advances in treatments and care, a new study finds. However, inequalities remain, with higher mortality in deprived areas.
Women are more likely to survive cancer than men but face a higher risk of serious and adverse side effects from treatment, according to a new international study.
A new targeted PET/CT tracer can detect treatment response in rheumatoid arthritis patients in as little as four weeks, and potentially even at the start of treatment, according to new research.
About 50% of triple-negative breast cancer (TNBC) patients develop resistance to therapy, significantly reducing the chances of survival. Researchers found there is more than one way this can happen.
“The bacteria effectively hide in a bunker”: New research reveals a surprising mechanism used by Acinetobacter baumannii and Pseudomonas aeruginosa to protect themselves from antibiotics.
Researchers have created a ‘cyborg’ pancreas device - an ultrathin mesh of conductive wires within growing pancreatic tissue - that could open up new ways for treating diabetes.
Analytical and measurement technology copany Horiba has obtained CE IVDR certification for its new Yumizen H500 CRP benchtop hematology analyzer, designed for small laboratories.
Should younger and older people receive different treatments for the same infection? New research suggests that age-specific treatments may be necessary in ongoing antibiotic resistance crisis.
Immunotherapy has been hailed as a breakthrough in cancer treatment. But new research reveals: under sustained treatment pressure, cancer does not simply weaken — it adapts, learns, and fights back.
Scientists from Northwestern University have developed an injectable regenerative nanomaterial that helps protect the brain during the vulnerable window after a stroke.
A new University of Toronto-led study has discovered a possible biomarker linked to multiple sclerosis (MS) disease progression that could help identify patients most likely to benefit from new drugs.
Now, a research team has developed a novel diagnostic approach that enables the rapid and simultaneous detection of both antibiotic resistance and high virulence in Klebsiella pneumoniae.
Cardiovascular disease and depression do not co-occur by chance; the TO_AITION project aims to enable earlier diagnosis of comorbidity, better risk prediction and personalised treatment strategies.
To soften up tumors prior to cancer chemotherapy, a team of researchers paired high-frequency ultrasound waves with a type of sound-responsive particle to reduce the protein content of the tumors.
After T-cell redirecting therapies, patients are typically hospitalized for several days to watch for side effects. New research shows that these patients can safely be monitored at home.
New insights into the intestinal nervous system – or "gut brain" – open new avenues for advancing therapies for allergies, chronic inflammatory bowel diseases and irritable bowel syndrome.
A major new initiative aims to enable the development of advanced, specific and highly reproducible human in vitro models for greater understanding of disease and the acceleration of new medicines.
Bioptron Hyperlight Therapy is a certified medical device that uses a patented form of polarized, polychromatic, non-coherent light. The therapy works by delivering specific light characteristics, which stimulate local blood microcirculation, enhance cellular regenerative process, decrease pain and stimulate immune system. This non-invasive and painless photobiomodulation method is clinically…
Most patients with metastatic colorectal cancer do not respond to immunotherapy—but why? A new study shows how the tumours block the immune system through two complementary mechanisms.
Biomarker testing is ushering in a novel era of therapy personalisation for gastroesophageal and colorectal cancers, according to experts presenting at the 37th European Congress of Pathology in Vienna this September. During a session on state-of-the-art in gastrointestinal biomarkers, speakers outlined how targeted therapies and immunotherapies are transforming treatment options – but…
Researchers have discovered a previously unknown mechanism that explains how bacteria within a tumor can drive treatment resistance in patients with oral and colorectal cancer.
Researchers identified a targeted way to protect the brain from harmful side effects of cranial radiation therapy, potentially preserving the quality of life for millions of brain cancer survivors.
Chronic fatigue (ME/CFS) affects millions worldwide, but is poorly understood and has long lacked reliable diagnostic tools. Now, a new blood test claims to diagnose the condition with 96% accuracy.
The heterogeneity of critical illnesses like sepsis, ARDS, and trauma creates immense challenges. A new, unified way to classify patients aims to improve treatment.
Immunotherapy has improved the treatment for many cancers, but progress has been limited in leukemia. Discovery of a new evasive mechanism could help change that.
Scientists have shown for the first time that glioblastoma—the deadliest form of brain cancer—affects not just the brain but also erodes the skull, alters the makeup of skull marrow, and interferes with the body’s immune response.
Scientists created precise replicas of Candida sugar coats to understand immune responses, enabling fast bedside testing that could replace slow lab cultures.
German researchers discover how HIV selects genome integration targets using RNA:DNA hybrids as guides, revealing new therapeutic approaches for controlling viral reservoirs.
A newly developed method to accurately quantify how much radiation is absorbed by the blood during cancer treatment could lead to more personalised, preventive, and safer radiotherapy.
Studies have found that natural polysaccharides from a medical fungus endemic to Taiwan can not only effectively inhibit inflammation, but also fight the proliferation of lung cancer cells.
Defining four different immunologic subtypes of recurrent ovarian cancers, researchers pave the way for more personalized treatment.
A new, bacteria-based contrast agent illuminates tumors like a neon sign during surgery, enabling more precise resection and reducing the risk of recurrence.
Korean researchers have developed a wireless implantable drug delivery system that enable chemotherapy drugs to penetrate deep into solid tumors—without harming surrounding healthy tissue.
Molecular profiling of over 1,000 nasopharyngeal cancer (NPC) tumours reveals distinct differences in tumour microenvironment of locoregionally advanced NPC, supporting personalised treatment.
New research shows how embryos can protect themselves from bacterial infections even before forming their immune system. The findings could provide new insights into the origin of immunity.
Tongue squamous cell carcinoma, the most common type of oral cancer, is a challenging target for immunotherapies. Researchers now identified five immunotypes to better predict treatment response.
Newborns, especially those born prematurely, are vulnerable to conditions such as sepsis. A new device profiles an infant’s immune function from a single drop of blood to improve neonatal care.
A US research team has shown that Sars-CoV-2 can “reprogram” pathogen-fighting white blood cells into immune system suppressing cells — a potential mechanism by which severe Covid may arise.
A gene once believed to fight only viral infections could also hold the key to preventing memory loss in Alzheimer’s patients, a new study finds. This paves the way for new drug developments.
At the San Antonio Breast Cancer Symposium (SABCS), three experts presented new approaches and study results for the treatment of breast cancer in young women.
Unprecedented insights into the inner workings of an early-stage lung tumor: An international research team describes a new method for 3D mapping cellular interactions in the tumor microenvironment.
Researchers developed biomimetic materials inspired by lymph nodes, which could improve cancer immunotherapy. The study highlights the potential of bioengineered scaffolds for cell-based therapies.
New research has revealed how Duchenne muscular dystrophy (DMD) also profoundly affects the brain, leading to cognitive and behavioural challenges that are very diverse and some could be reversible.
Researchers discovered a key mechanism by which melanomas and other aggressive tumours prevent the immune system from detecting and attacking them – one of the greatest challenges in oncology today.
Japanese researchers have developed magnetic nanoparticles that can be directed to tumors using a magnet and then heated with a laser to destroy cancer cells while sparing healthy tissue.
The gastrointestinal microbiome holds valuable information that can help predict whether immunotherapy will be successful against melanoma. A new “gut-on-a-chip” is designed to do exactly that.
When multiple myeloma cancer cells break out and multiply outside the bone marrow, a wide variety of tumor cells arise, accompanied by a significantly altered immune response, new research shows.
Researchers have developed a new kind of tumour-on-a-chip, which gives insight into the tumour environment and immunotherapy response. The device has been successfully tested on breast cancer samples.
Persister cells arise as a result of cancer treatment and are often responsible for tumour relapse. Researchers identified a distinctive feature of persister cells, paving the way for new treatments.
“What is a tumour?” Researchers explore tumour architecture as a valuable source of information to understand tumour dynamics and predict its sensitivity to anticancer drugs.
The immune system of children reacts differently to cancer than that of adults. New insights into these differences have the potential to lead to new tailored treatments for children with cancer.
A new study measured how well breast cancer patients’ tumour ‘explants’ respond to chemotherapy or HER2 antibody therapy in the laboratory. This could help improve clinical outcomes.
Light can change biological processes and affect health. For example, new research finds that red light can lower rates of blood clots that can cause heart attacks, lung damage and strokes.
Why does radiation therapy kill cancer cells from the same tumour in different ways? This has long remained poorly understood. Now, new findings open up opportunities to improve treatment.
Researchers have developed an AI-based model to better predict whether cancer patients will benefit from immunotherapy — using only routine blood tests and clinical data.
Researchers now succeeded in making leukemia-specific immune cells less sensitive to the influence of tumor cells, thereby significantly increasing their effectiveness.
Research offers new insights into harnessing the immune system to combat ovarian cancer. The findings could lead to personalized therapies that target the right patients at the right time.
New insights into the previously unknown diversity of cancer-associated fibroblasts in basal cell carcinoma, squamous cell carcinoma and melanoma could pave the way for new therapies.
A new approach to fight glioblastoma: Swiss researchers have now developed an immunotherapy that not only attacks the brain tumor—it also turns its microenvironment against it.
PET/CT image analysis using artificial intelligence (AI) can predict the occurrence of interstitial lung disease, a serious side effect of immunotherapy in lung cancer, a new study shows.
Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.
Hyperbaric oxygen therapy (HBOT) treatments could offer relief to breast cancer patients who experience late toxicities following radiotherapy treatment. To date, the handful of completed clinical trials only produced inconclusive or contradictory results. Therefore, results from the latest trial, named HONEY (Effect of Hyperbaric Oxygen Therapy on Breast Cancer Patients with Late Radiation…
Multiplex imaging can play a critical role in unravelling the tumour microenvironment. The potential and benefits of the emerging approach – a way to extract information from human tissue samples by visualising many more biomarkers than traditional microscopy – was highlighted in presentations during the 36th European Congress of Pathology in Florence, Italy. Speakers also discussed novel…
In many cases, metastatic breast cancer is still incurable. To improve the odds, researchers have now analyzed the diversity of metastatic cells and their interactions with their cellular environment.
A new method could open new avenues to quick, affordable cancer diagnosis, US researchers report. The method uses ultrathin membranes to capture extracellular vesicles.
New insights into metastasis: Scientists created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells. This could help discover new screening and treatment options.
Immunotherapy has become the most promising strategy for treating several cancers, but its effectiveness is still very uneven. Three researchers explain how research is being done to change this.
By combining mass spectrometry and mass cytometry imaging techniques, researchers can now dive deeper into tumors and map the metabolism of individual cells in tumor tissue.
Scientists at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue.
Researchers have succeeded in identifying patterns of response to treatment in patients with multiple myeloma using AI tools, which helps to accurately predict the evolution of the tumor.
STAb-T, a new form of immunotherapy to treat solid tumours shows therapeutic potential in animal models with non-small cell lung cancer. The new strategy is designed to strengthen the defensive cells.
Only 20-40% of patients respond positively to immunotherapy, and these rates vary across different types of cancer. Researchers now identified five key factors that determine response and survival.
Currently, it is difficult to predict whether a cancer patient will respond to immunotherapy or not. A new method to quantify the heterogeneity of the tumour microenvironment aims to improve this.
Researchers have identified fibrotic scarring as a key source of resurgence of glioblastoma multiforme (GBM). The new insights could lead to better prevention of this type of brain cancer.
A US-Swiss team leverages AI and molecular simulations to uncover new pathways for precision cancer treatments, paving the way for more effective, personalized therapies.
Immunocompromised patients are at greatest risk of developing severe Covid-19 after an infection. While early antiviral treatments yield best results, even late-onset therapies still show benefits.
Brazilian researchers have identified a key mechanism of Sars-CoV-2 to manipulate its host’s immune defense. This discovery could pave the way for the development of novel therapies.
Systemic lupus erythematodes can lead to severe kidney damage. However, until now, the cause for this remained unclear. New research has now revealed the underlying mechanism.
Metastases, but no sign of the original tumor: A large international study shows how this phantom cancer can nevertheless be treated.
Researchers discovered islands of highly potent immune cells in the vicinity of glioblastomas. This may open up prospects for new therapies for these aggressive brain tumours.
The pace of artificial intelligence (AI) adoption in personalised medicine is unsettling for great parts of the public. A new survey reflects the worried state of mind in the UK.
Ductal Carcinoma in Situ (DCIS) often develop into more invasive forms of breast cancer. To predict which DCIS patients are likely to be affected, researchers have developed an analytic AI-based tool.
A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.
The new Nuclear Medicine Department of the San Pietro Fatebenefratelli Hospital was inaugurated in Rome. The Department was inaugurated with the online intervention of Health Minister Orazio Schillaci and in the presence of Maria Tripodi (Undersecretary at the Ministry of Foreign Affairs and International Cooperation), Antonello Aurigemma (President of Lazio Regional Council).
Scientists discover how the production of antibodies is regulated in allergy and infections. This opens the door to new therapies, without affecting the beneficial response of the immune system.
Pancreatic cancer stem cells exploit an antibacterial protein to evade the immune system. Removing this protein could pave the way to more effective immunotherapy, new research suggests.
Immunotherapy increases survival rates in kidney cancer, but does not work for everyone. A research team developed a new method to predict which patients will benefit from it.
New research into a life-threatening, but underestimated complication in lung transplants not only provides new insights, but also approaches for early detection and timely treatment.
Researchers developed a new type of anticoagulant whose action can be rapidly stopped. This reversible activity could revolutionise the use of anticoagulants in surgery or other applications.
In some patients with multiple sclerosis (MS), symptoms worsen during treatment, but MRI scans do not indicate any change. In such cases, positron emission tomography could help, a new study suggests.
Findings from the largest UK study of patients hospitalised with Sars-CoV-2 infection show that long Covid leads to ongoing inflammation which can be detected in the blood.
Bacteria can help – or hinder – the treatment of cancer. How this happens, however, is largely unknown. Now, researchers have mapped bacteria in cancer metastases to shed more light on their role.
Researchers discovered three distinct immunological endophenotypes of multiple sclerosis, defined by specific blood immune signatures. This opens new avenues for personalized treatment strategies.
A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn’s disease.
In a breakthrough for personalised oncology, scientists have developed and demonstrated a novel platform that can significantly reduce the time needed to determine the efficacy of anti-cancer drugs.
A new radiotherapy technique, which delivers high doses of radiation in a matter of seconds, spares the surrounding tissue and, according to initial data, has fewer side effects.
Researchers have unveiled a detailed understanding of immune responses in cancer, potentially paving the way for the development of new therapeutic strategies, the team hopes.
Under certain circumstances, lung tumours can transform into another, more aggressive cancer type. Now, researchers have found a way to illuminate this process, known as histological transformation.
Researchers in Japan and the US have developed technology to robustly augment the amount of MHC class I molecules in cancer cells. This makes them easier to find and destroy for the immune system.
Neuroscientists recently discovered that low-dose ionizing radiation (LDIR) can reduce lesion size and reverse motor deficits in TBI and ischemic stroke mice, demonstrating its therapeutic potential.
Chemotherapy against cancer can lead to the generation of senescent tumour cells, which can help the tumour survive. A new immunotherapy approach to eliminate these cells shows promise in animal models.
The underlying mechanisms of Guillain-Barré Syndrome (GBS) have remained largely unknown until now. New research now uncovers a pivotal aspect of GBS pathophysiology.
Coronavirus vaccines have showcased the possibilities of messenger RNA (mRNA) technology. Now, a research team aims to put it to use against a rare inherited metabolic disorder.
A research team has successfully developed “NK cell-engaging nanodrones” capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable cancer types.
A low-cost technology involving nano-sized antimicrobial compounds against tuberculosis has been developed by researchers at São Paulo State University (UNESP).
Researchers have created a first-of-its-kind immune cell atlas of the developing lung, revealing coordination between the immune and respiratory systems much earlier than previously thought.
Scientists map the effects of 86 immune-signaling molecules called cytokines on every major immune cell type, creating a reference for studying the inner workings of the immune system.
The Covid-19 pandemic has affected scientific research in numerous ways – for example by highlighting knowledge gaps in gender medicine. In many studies differences in morbidity and mortality between women and men surfaced incidentally. While the extent and causes of these differences remain largely unexplored, the preliminary insights confirm the need for further research.
Scientific articles about psiorasis suffer from a shortage of actual patient images, according to a new study. This makes it hard for patients to grasp the condition, the authors argue.
Pancreatic cancer is not just one disease, but that’s the way it is currently treated. New work from Columbia University could help pave the way for a change.
Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. Now, lymphoma specialists in Essen are investigating the possibility of a different approach.
University of Basel scientists have discovered that high levels of the amino acid arginine drive metabolic reprogramming to promote tumor growth. This could lead to improved liver cancer treatment.
University of Oxford researchers demonstrated that neural cells can be 3D printed to mimic the architecture of the cerebral cortex. This could be used in patients after brain injuries.
Researchers at the University of Michigan have zeroed in on Candida auris – a fungus with the uncanny ability to stick to everything from skin to catheters – and made a startling discovery.
US researchers have discovered that radiation therapy combined with two types of immunotherapy can control tumors in preclinical models of triple negative breast cancer.
A new onco-therapeutic vaccine candidate against human papillomavirus (HPV)-induced cancers, such as cervical and oropharyngeal cancers, has shown promising results in the preclinical phase.
A newly discovered mechanism involving exosomes can drive inflammation and impair healing of wounds in diabetes patients, according to a new study led by University of Pittsburgh and UPMC researchers.
A new research breakthrough could lead to the development of new treatments for people with compromised immune systems, such as those with cystic fibrosis.
Patients with immunodeficiency cannot benefit from conventional Covid-19 vaccines and still at risk from infection. A promising new approach now brings hope for this patient group.
A new analysis exploring the finances of bringing new cancer drugs to market has found that precision oncology drugs could be $1 billion cheaper to develop than non-precision drugs.
Centralized review of slides combined with telepathology has opened up the potential for a dramatic reduction in the waiting times for breast cancer patients to start their therapy. Jan Hudecek from the Netherlands Cancer Institute outlined his team’s framework for multi-centre clinical trials with centralized digital pathology review at the 9th Digital Pathology and Artificial Intelligence…
Brain tumour progression to a malignant state is believed to be the result of an intricate interplay between cancer cells and the tumour microenvironment. Greek researchers shed new light on the mechanisms.
While screening programs for several of the commonest cancers are now well established, lung cancer screening has yet to reach anywhere near the same proportion of at-risk patients.
Researchers have unveiled a key mechanism of breast cancer cells to infiltrate lymph nodes. The discovery may lead to new metastasis-blocking treatments and improve patients’ lives.
Researchers at Mayo Clinic have developed a 3D prototype of human skin bioprinted to model inflammatory skin disease such as atopic dermatitis — more commonly known as eczema.
A new study led by researchers from the University of Notre Dame links a high body mass index (BMI) to alterations in the structure and environment of cancerous tumors.
A new US-led study shows that astrocyte brain cells play an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.
Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy treatment that re-engineers a patient’s own T-cells to help them attack malignant tumour cells. It has been very effective in the treatment of blood cancers, including certain types of leukaemia and lymphoma. However, two serious side effects are common as a result of the treatment: cytokine release syndrome (CRS) and immune…
US researchers identified a potential breakthrough in glioblastoma treatment. Using a modified virus, they created a treatment that specifically attacks tumor cells, while leaving normal cells intact.
French scientists discovered that CD4 T cells generated during immunotherapy are capable of remotely neutralizing tumor cells by producing interferon gamma (IFN-γ).
One day, the ultrasound equipment that health care professionals use for diagnostic imaging may no longer be confined to the clinic, instead operated by patients in the comfort of their homes.
Unanswered questions are hampering clinicians in their efforts to get the best out of a precision medicine approach for their patients. Speaking at the Genomics and Precision Medicine Expo in London at the end of May, cancer educator Dr Elaine Vickers said the benefits of being matched to an investigational drug remain questionable for most people with advanced cancer.
Researchers at Karolinska Institutet have found further evidence for how the Epstein-Barr virus (EBV) can trigger multiple sclerosis (MS) or drive disease progression.
A new class of immunotherapy shows promising results for fighting the most aggressive form of skin cancer.
Women with triple-negative breast cancer who received multiple antibiotic prescriptions within three years after their cancer diagnosis were more likely to experience disease recurrence and to die from their cancer.
For decades, researchers have marveled at the ability of glioblastoma, a particularly aggressive brain cancer, to turn off a patient's cancer-fighting immune cells, thereby allowing tumors to grow freely.
Genes are full of clues about a person's health and might also show the way for stroke recovery.
A new artificial intelligence model could bring much-needed clarity to doctors delivering prognoses and deciding on treatments for patients with colorectal cancer.
New research has found molecular signature differences in the blood of patients who fully recover from Covid-19 and those who develop long Covid.
For pancreatic cancer, the effect of immunotherapy is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference.
French scientists are developing and testing a new vaccine to combat allergic asthma. Their latest study results pave the way for the organization of a clinical trial.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.
A new study confirms that haematopoietic stem cell transplantation can be used to cure patients with HIV infections. This third successful case gives new insights into the underlying processes.
Researchers in Frankfurt have now been able to show how ferroptosis can be used to make immunotherapies against liver cancer more effective in mice.
Evidence that radioembolization, a trans-arterial therapy, is safe and stops disease progression in metastatic breast cancer is increasing, a prominent American interventional radiologist showed at the Spectrum conference in Miami.
In a world first, scientists from Singapore and Germany have shown that regenerative therapy to restore impaired kidney function may soon be a possibility.
High-intensity focused ultrasound (HIFU) ablation is a noninvasively treatment for benign thyroid nodules that are causing distress to patients. Brian H. H. Lang, MD, Clinical Professor in the Department of Surgery at the University of Hong Kong, and chief of the Division of Endocrine Surgery at Queen Mary Hospital, is a preeminent investigator, proponent, and pioneer of this technique. He…
Focused ultrasound (FUS) ablation is an emerging treatment for breast tumours. Its use was highlighted in an October webinar focused on emerging immunotherapy research and breast cancer.
Dutch scientists have discovered how specialized immune cells can detect and remove cancers that are ‘invisible’ to the conventional defense mechanisms of the immune system.
Immunotherapy prior to surgery is surprisingly effective for patients with a certain type of colorectal cancer (dMMR/MSI-H CRC). These new study results contrast current treatment regimens.
Findings of bacteria with anti-inflammatory effects in the intestines of MS patients with no evidence of active disease indicate that diet, bacteria and disease progression are linked.
Scientists have discovered a way to train healthy immune cells to acquire the skills of some tumor cells for a good purpose: to accelerate diabetic wound healing.
Researchers have developed a so-called “heart attack on a chip”, which could one day serve as a testbed to develop new heart drugs and even personalized medicines.
A pioneering ‘smart contact lens’ to test the eye in a quick, non-invasive way could prevent deaths caused by fungal eye infections in developing countries.
Canadian researchers have developed a new method of killing brain cancer cells while preserving the tissue around it. A remarkable side-benefit: chemotherapy of the cancer suddenly becomes possible.
This summer, The European Commission launched I3lung, a new research initiative as a part of Horizon Europe, the EU’s research and innovation program. This research initiative aims to create a cutting-edge, decision-making tool to help clinicians and patients select the best lung cancer treatment based on each patient’s specific needs and circumstances.
At this year's Medica tradefair, laboratory medicine, medical technology and life sciences give new impulses to the entire healthcare market - especially in times of the corona pandemic. An overview.
Blood stem cell transplantation is a radical but highly effective therapy for multiple sclerosis. A study examined how the treatment curbs the disease and how the immune system regenerates afterwards.
Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease.
Until now, it was feared that vaccination against Covid-19 could reduce the success of treatment for patients with nasopharyngeal cancer. A recent study now gives the all-clear in this regard.
Researchers from Barcelona report that vaccination with senescent cells shows promise in experimental models of melanoma and pancreatic cancer.
99mTc-Sestamibi SPECT/CT can aid in the diagnosis of solid renal lesions, especially in cases where contrast enhanced CT findings are inconclusive, according to researchers from the Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis, Missouri.
Some leukemias evade treatment by changing their appearance and identity through changing the read-out of their DNA, a new study has found.
Researchers mapped in detail how the immune system acts against pathogens invading the brain. This sheds new light on host-pathogen interactions and the long-term consequences of brain infections.
Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.
UC San Francisco researchers have developed a drug marking cancer cells for destruction by the immune system.
Arthroplasty treatment of fragile patients is a major challenge faced by orthopaedic surgeons. The patients, often geriatric, come with a variety of risk factors and comorbidities that can negatively impact the success of an arthroplasty procedure.
Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.
A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.
Researchers have developed adeno-associated virus variants that target heart muscle cells and can thus be used for the precise treatment of heart diseases.
Cancer immunotherapy is a successful treatment form in oncology, but it doesn't work for every patient. One problem may be the lack of a specific type of immune cell in the tumor, researchers found.
Researchers have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade.
Latest developments in computational protein design enable the simulation of sequence and structural changes in proteins for creating novel agents in human medicine.
"Crown-like structures" surrounding breast tumors in overweight and obese patients could hinder their response to therapy. The findings of this study could potentially be used to improve personalized treatment for patients.
Bacteriophages – viruses that kill bacteria – could be a solution for fighting antibiotic-resistant pathogens, French researchers have developed a model to better predict their efficacy.
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
Researchers have developed advanced computer models, or “digital twins”, of diseases, with the goal of improving diagnosis and treatment.
A method for delivering genetic material to the body that has proven useful in Covid-19 vaccination is now being tested as a way to repair damaged heart muscle after a heart attack.
A major advance demonstrates first multi-organ chip made of engineered human tissues linked by vascular flow for improved modeling of systemic diseases like cancer.
Cedars-Sinai physician-scientists are pioneering imaging techniques and investigating new biomarkers to improve multiple sclerosis (MS) diagnosis and treatment.
A chip-based infection model developed by Jena researchers enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis.
Delivering a drug directly inside a lesion using minimally invasive procedures opens up new perspectives for patients and medical teams. At ECR Overture, experts looked at how to best join forces to advance the field of interventional oncology.
A new biodegradable gel improves the immune system’s ability to keep cancer at bay after tumors are surgically removed.
Reducing inflammatory mediators in the blood before surgical treatment of cardiac bacterial infection does not improve clinically relevant outcome, a new study shows.
Liquid profiling is offering clear benefits in terms of cancer diagnostics and targeted therapy, but challenges remain in bringing it into the clinic.
A new study has analyzed over 3000 proteins to identify which are causally linked to the development of severe Covid-19. This provides insight into potential new targets for treatment and prevention.
Pre-transplant chemotherapy facilitates the replacement of the brain's innate immune cells, by other immune cells derived from the transplanted stem cells.
A new study offers hope against liver cancer: A vaccine proved to be safe and effective protection in premalignant and malignant liver diseases in preclinical mouse models.
French researchers have found a way to facilitate access to tumours for killer lymphocytes, paving the way for more efficient immunotherapies against cancer.
Light therapy may accelerate the healing of skin damage from radiation therapy by up to 50%, according to a recent University at Buffalo-led study.
In both the mice and organoids, cytokines suppressed tumor growth after treatment, and defense cells migrated to the brain region affected by the tumor, alerting the immune system to its existence.
Since its introduction around 60 years ago, the screening of newborn babies for immune, hormone and metabolic disorders has prevented many people from experiencing severe disease progression. The scope of systematic early testing has been significantly enhanced through mass spectrometry (MS). In our interview, Professor Uta Ceglarek, one of the driving forces behind the introduction of MS…
Mammograms are a safe, effective way to detect the presence of breast cancer in women. But doctors recommend most females should start getting mammograms after the age of 40 in part because the procedure involves small doses of ionizing radiation. While the risk of getting breast cancer is higher for older people, it can strike at any age. Studies show that 5% to 7% of females with breast cancer…
In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients. Scientists at the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and the National Center for…
Professor Regina Beets-Tan, President of the European Society of Radiology (ESR), looks on possible future developments in cancer imaging. AI is very promising in this regard, 'However, it has proven to be a problem that the data with which the artificial intelligence is fed must be very homogeneous,' the expert observes.
Leading functional & smart textile manufacturer Asiatic Fiber Corporation (AFC) introduces advanced wearable technology for electronic muscle stimulation (EMS) and transcutaneous electrical nerve stimulation (TENS): (EMS module / E-massage module) of the iQmax® series at the international trade fair MEDICA 2021, which will be held in Germany from November 15th to 18th.
Researchers from Cleveland Clinic have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body’s immune response. The…
The immune system protects the body from cancer. To protect healthy body cells from its own immune system, they have developed a protective shield: the protein CD47 is a so called "don’t eat me" signal, which tells the immune cells to stand back. Tumor cells exploit this CD47-based protection strategy for evading the immune system, by increasing presentation of CD47 on their cell…
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria’s ability to cause disease and repurposing it to attack harmful microbes instead.
After a liver transplant, patients have to take immune-suppressing drugs for the rest of their lives. These so-called immunosuppressants prevent the organ from being rejected. However, the drugs increase the risk of cancer and serious infections. They can also significantly impair kidney function and even lead to dialysis. In order to be able to give those affected as much immunosuppression as…
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
According to new research, vaccinated people are at greatest risk from severe Covid-19 leading to hospitalisation or death from 14 days post the second dose vaccination, when substantial immunity should be expected.
Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to an immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.
Over the past decade, scientists have been exploring vaccination as a way to help fight cancer. These experimental cancer vaccines are designed to stimulate the body’s own immune system to destroy a tumor, by injecting fragments of cancer proteins found on the tumor.
A team led by the Garvan Institute of Medical Research has revealed a new approach for classifying breast cancer subtypes based on their cell profile, which could help personalise treatments for patients. By analysing breast cancer biopsies from patients at Sydney hospitals, the researchers revealed more than 50 distinct cancer, immune and connective cell types and states, which could assign…
A new technology that can study which therapies will work on patients with solid cancerous tumours has been developed by scientists at University College London (UCL). Researchers say the tool, which can rapidly test tumorous tissue against different treatments, such as chemotherapy, immunotherapy or radiotherapy, could be used by clinicians to pinpoint the best therapy for a particular patient.
Extremely premature infants are at a high risk for brain damage. Researchers at the University of Vienna and the Medical University of Vienna have now found possible targets for the early treatment of such damage outside the brain: Bacteria in the gut of premature infants may play a key role.
Researchers at Tel Aviv University have 3D-printed a first-of-its-kind glioblastoma tumor that mimics a living cancer malignancy, powering new methods to improve treatment and accelerate the development of new drugs for the most lethal type of brain cancer. Glioblastoma is notoriously fatal as it accounts for the majority of brain tumors and is highly aggressive. The average survival time of…
Researchers identify two sugar-binding proteins that impede the viral entry of circulating SARS-CoV-2 variants. The team, spearheaded by researchers at IMBA – Institute of Molecular Biotechnology of the Austrian Academy of Sciences – may have found the “Achilles’ heel” of the virus, with potential for pan-variant therapeutic interventions. The findings are now published in the EMBO…
A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial.
Antibiotic-resistant pathogens have become one of the greatest threats to public health. The basic mechanisms of resistance evolution have been well studied experimentally and are an important research field at Kiel University. An important factor in this context, but one that has received little attention so far, is the population size of the respective pathogen. Over the course of an infection…
A researcher at the Technical University of Denmark (DTU) has developed a mathematical model for use in automated image analysis of tissue samples. The model provides the possibility for better and more similar cancer prognosis and treatment.
Age-related macular degeneration (AMD) is the most common cause of blindness in developed countries affecting seven million in total in Germany, from which 500,000 people are suffering from late stage disease, around half of whom are registered as visually impaired. There are two forms of AMD, ‘wet’ and ‘dry’. There are currently no treatments available for the dry form of the disease…
Miniature tumours in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. “We’ve solved a major problem many scientists had been facing: preserving a tumours original composition and structure outside of the patient in the lab”, says cancer researcher Daniela Thommen.
Pioneering technology developed by University College London (UCL) and Africa Health Research Institute (AHRI) researchers could transform the ability to accurately interpret HIV test results, particularly in low- and middle-income countries. Academics from the London Centre for Nanotechnology at UCL and AHRI used deep learning (artificial intelligence/AI) algorithms to improve health workers’…
Researchers have identified a way to improve the immune response in the face of severe viral infections. It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune ‘exhaustion’. Overcoming immune exhaustion is a major goal for the development of new therapies for cancer or severe viral infections.
