Now, a research team has developed a novel diagnostic approach that enables the rapid and simultaneous detection of both antibiotic resistance and high virulence in Klebsiella pneumoniae.
Climate change, poverty, and drug resistance are combining to create an escalating health crisis that could become a ‘creeping catastrophe’ if left unaddressed, a new international study finds.
Depression is not only a disease of the mind or the brain, a new study finds: a research team has revealed deep connections to abnormalities in the body's overall immune response.
An international research team has discovered a promising new therapeutic approach for aggressive prostate cancer – in the thyroid gland.
Metal-organic frameworks (MOFs) serve as the basis for a novel type of MRI contrast agent, which the developers hope can outperform current agents while being less toxic for the patient.
Biomarker testing is ushering in a novel era of therapy personalisation for gastroesophageal and colorectal cancers, according to experts presenting at the 37th European Congress of Pathology in Vienna this September. During a session on state-of-the-art in gastrointestinal biomarkers, speakers outlined how targeted therapies and immunotherapies are transforming treatment options – but…
Traditional diagnostic methods for epilepsy face significant limitations. A new clinical trial explores the potential of advanced brain monitoring to improve diagnosis and management of the condition.
Researchers have discovered a previously unknown mechanism that explains how bacteria within a tumor can drive treatment resistance in patients with oral and colorectal cancer.
A new type of SPECT imaging provides strong prognostic information to guide prostate cancer treatments according to tumor evolution, significantly impacting patients' overall survival.
Breast cancer claims around 670.000 lives each year. Now, researchers propose that whole genome sequencing (WGS) could help many patients find better treatments or match them with clinical trials.
Scientists created precise replicas of Candida sugar coats to understand immune responses, enabling fast bedside testing that could replace slow lab cultures.
The number of patients with substance abuse disorders who are admitted to hospitals as inpatients has been steadily increasing. Hospitalists attending SHM Converge 2025, the annual meeting of the Society of Hospital Medicine (SHM) in Las Vegas this spring, were given practical advice on how to treat these patients.
German researchers discover how HIV selects genome integration targets using RNA:DNA hybrids as guides, revealing new therapeutic approaches for controlling viral reservoirs.
In metastatic EGFR-mutated non-small cell lung cancer (NSCLC), targeting residual disease through surgery can extend the benefits of EGFR TKI therapy beyond standard monotherapy, a new study finds.
Historically, implants to repair bone fractures have been made of metal, donor bone, or 3D-printed material. Now, scientists propose an in-situ printing approach - using a modified glue gun.
Hospitalists face a dual challenge when a critically ill pregnant patient is admitted to a hospital: providing safe and effective treatment for both mother and fetus. Pregnancy causes physiologic changes as well as anatomical ones, which complicates the assessment and medical management of pregnant women. At the annual meeting of the Society of Hospital Medicine (SHM) in Las Vegas, an expert…
Defining four different immunologic subtypes of recurrent ovarian cancers, researchers pave the way for more personalized treatment.
A new AI-based tool measures cancer aggressiveness by analyzing the ‘stemness’ of tumors – their similarity to pluripotent stem cells. This could pave the way for new therapies.
Korean researchers have developed a wireless implantable drug delivery system that enable chemotherapy drugs to penetrate deep into solid tumors—without harming surrounding healthy tissue.
New research shows that dysfunction in the mitochondria linked to amyotrophic lateral sclerosis (ALS) occurs before the cells show other signs of disease, which was not previously known.
Finding ways to target antibiotic-resistant bacteria is a scientific and medical priority. A consortium of researchers identified a compound capable of blocking a key protein for virulence, thus “disarming” the pathogenic bacteria.
A newly discovered type of cells counteract tumor development and may therefore be a target for research into new treatments for pancreatic cancer, which is one of the deadliest forms of cancer.
Ending epidemics like HIV, tuberculosis, hepatitis and STIs by 2030 is a key health goal for Europe. Although progress has been made, many EU countries are not on track to meet the goals, experts say.
Pancreatic cancer is one of the most aggressive cancers, partly due to its tumor microenvironment, known as the stroma. Now, a study has identified a new key factor contributing to this feature.
Using ‘parallel transmit’ technique, researchers have found a new way to detect lesions in the brain of patients with treatment-resistant epilepsy in an MRI scan, without imaging signal dropouts.
Transmission of tuberculosis (TB) in the European Region is still ongoing, and immediate public health measures are needed to control and reduce the growing burden of the disease, experts urge.
World TB Day raises awareness about tuberculosis and commemorates the discovery of the source bacterium M. tuberculosis. More than a century later, scientists still refine anti-TB strategies.
Nuclear cardiology is a specialised field in nuclear medicine that evaluates the heart function to help diagnosing conditions such as coronary artery disease and to assess treatment efficacy, whilst minimising invasive procedures like biopsies. More recently, clinicians have increasingly opted for nuclear imaging over endomyocardial biopsy to diagnose cardiac amyloidosis, allowing for earlier…
Microbiologists have just shown that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, a leading cause of AMR-associated infections and deaths.
Persister cells arise as a result of cancer treatment and are often responsible for tumour relapse. Researchers identified a distinctive feature of persister cells, paving the way for new treatments.
Two recent studies find that resistance can develop against new antibiotics even before they are widely used, compromising their effectiveness from the start.
“What is a tumour?” Researchers explore tumour architecture as a valuable source of information to understand tumour dynamics and predict its sensitivity to anticancer drugs.
Tongue cancer cells can become resistant to chemotherapy under certain circumstances. Investigating these mechanisms, researchers shed light on promising avenues toward new treatments for this cancer.
Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of breast cancer chemotherapy while reducing its harmful side effects.
Researchers now succeeded in making leukemia-specific immune cells less sensitive to the influence of tumor cells, thereby significantly increasing their effectiveness.
A new radiotracer – an injected compound used in PET scans – could help inform doctors that a patients aggressive cancer will not respond to chemotherapy before treatment is given.
A new MRI-based imaging technique predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.
The current rise in antibiotic resistance is once again sparking interest in phage therapy. Now, scientists developed a new tool that recommends the best possible phage cocktail for a given patient.
Two studies indicate warning signs about spread of bacteria resistant to the same group of antibiotics (carbapenems) in both healthcare and community settings across Europe.
In the laboratory, researchers increased the bactericidal effect of antibiotics 64-fold with the use of a new hydrogel. The material made the antibiotics effective even against resistant bacteria.
Nanoplastics are not only bad for the environment: A new study has shown that minuscule particles of plastic which enter the body also can impair the effect of antibiotic treatment.
It would seem that developing antibiotic resistance would give bacteria an immense advantage over their non-resistant counterparts. So, why do they not become dominant? New research may provide an answer.
Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.
UK scientists are harnessing the power of AI to assess the antimicrobial resistance of patients in intensive care units (ICUs) and identify sepsis-causing bloodstream infections.
Rsearchers developed a novel bioelectronic device that taps into the natural electrical activity of certain bacteria found on our skin, paving the way for a drug-free approach to managing infections.
New insights into metastasis: Scientists created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells. This could help discover new screening and treatment options.
Alzheimer’s disease may damage the brain in two distinct phases, based on new research funded by the National Institutes of Health (NIH) using sophisticated brain mapping tools.
While awareness for antimicrobial resistance (AMR) in bacteria is relatively high, fungal pathogens remain largely ignored – a blind spot with potentially dire consequences for global health.
Researchers have identified fibrotic scarring as a key source of resurgence of glioblastoma multiforme (GBM). The new insights could lead to better prevention of this type of brain cancer.
Infections caused by antibiotic-resistant (AMR) bacteria are a major issue in hospitals. A new technique aims to effectively track all types of relevant microorganisms simultaneously.
Klebsiella is among the top three pathogens responsible for hospital-acquired infections (HAIs). Now, researchers discovered why the bacteria thrive in clinical environments.
A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.
Why does the immune system sometimes fail to control the development of bowel cancer? UK and Dutch researchers discovered how cancer cells use a genetic "switch" to evade detection.
Researchers at Stanford have demonstrated that conditions in the matrix surrounding pancreatic cancer cells impact whether those cells respond to chemotherapy.
Integrating bacterial genomic data with detailed human mobility data makes it possible to see how pathogens causing pneumonia and meningitis, move between regions and evolve over time.
Finnish researchers discovered a mechanism that wakes up dormant breast cancer cells and demonstrated that preventing the mechanism can significantly improve treatment outcomes in experimental models.
Pancreatic cancer stem cells exploit an antibacterial protein to evade the immune system. Removing this protein could pave the way to more effective immunotherapy, new research suggests.
Tissue biopsy and liquid biopsy can increasingly be used as complementary or alternative approaches, with advantages and limitations to each. While speakers at the recent 35th European Congress of Pathology in Dublin were quick to highlight that liquid biopsy was not about to replace tissue biopsy, the focus looked at the benefits and challenges of each through the lens of four expert speakers.
Antimicrobial-resistant infections have become a global threat, with an annual death toll of over 1 million. Now, reseachers created a promising vaccine candidate for antibiotic-resistant bacteria.
A new SPECT/CT imaging technique using lead-212 (²¹²Pb) shows promise in targeted alpha therapy (TAT) for patients with metastatic castration-resistant prostate cancer.
Catheter ablation of atrial fibrillation is an important treatment option for heart rhythm maintenance and symptom reduction. Now, an international consensus statement reflects new techniques.
Researchers are developing novel active substances designed to cut off the nutrient supply of resistant bacteria, effectively starving them to death.
Targeting a specific protein, Finnish researchers may have found a way to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment.
Researchers in Japan and the US have developed technology to robustly augment the amount of MHC class I molecules in cancer cells. This makes them easier to find and destroy for the immune system.
Researchers have analysed the rise of antibiotic resistance over the last 20 years in the UK and Norway, highlighting that antibiotic use is not the only factor in the increase.
A new synthetic antibiotic developed by University of Liverpool researchers is shown to be more effective than established drugs against ‘superbugs’ such as MRSA, a new study shows.
Given the limited success of traditional therapies for depression, recent years have witnessed the emergence of technology-based interventions. One such intervention is transcranial electromagnetic stimulation (TMS).
A low-cost technology involving nano-sized antimicrobial compounds against tuberculosis has been developed by researchers at São Paulo State University (UNESP).
Scientists map the effects of 86 immune-signaling molecules called cytokines on every major immune cell type, creating a reference for studying the inner workings of the immune system.
Assays: Clozapine, Risperidone, Aripiprazole, Olanzapine, Quetiapine, Paliperidone Highlights:Antipsychotic drug monitoring provides healthcare professionals accurate and vital information.Testing of antipsychotic drugs can help manage patient therapy by providing greater clarity on the causes of treatment failure (i.e., adherence, drug resistance, drug-drug interactions and drug…
In a new study, UCLA researchers demonstrated how small cell neuroendocrine prostate cancer tumor cells can arise from less aggressive prostate tumors.
Cedars-Sinai Medical Center, a non-profit hospital and medical research institution in Los Angeles, is setting new standards for quality and innovation in patient care by successfully introducing typing of Candida auris species – a procedure that could prove crucial in protecting patients from infection outbreaks caused by these microbes in healthcare settings.
A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.
A new study on public health communication shows that the term commonly used to describe bacteria resistant to current medicines or antibiotics fails to stick in people’s memories.
A team of researchers from Vienna has discovered that dormant breast cancer tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein.
US researchers have discovered that radiation therapy combined with two types of immunotherapy can control tumors in preclinical models of triple negative breast cancer.
A new class of antibiotics, based on proven drugs used in cancer treatment, is now being developed by researchers at Linköping University. They could be used against resistant bacteria.
US researchers identified a potential breakthrough in glioblastoma treatment. Using a modified virus, they created a treatment that specifically attacks tumor cells, while leaving normal cells intact.
Governments around the world must do more to tackle the growing threat of drug-resistant infections, new research led by the University of Leeds suggests.
AI could find critical biomarkers that predict non-response to conventional treatment in patients with chronic myeloid leukaemia (CML) more quickly, researchers in Singapore find.
Tumors sometimes seem to take on a life of their own, with cancer genes “striking out” in ring shapes. An international research team has new insights into this phenomenon.
Newly developed “smart” coatings for surgical orthopedic implants can monitor strain on the devices to provide early warning of implant failures while killing infection-causing bacteria.
Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the chemotherapy of testicular cancer.
When in doubt, write a prescription? New research links burnout in GPs to higher antibiotic and strong opioid prescribing, especially in more deprived areas of the North of England.
Chemotherapy resistance is a main cause of treatment failure and death in cancer patients. Researchers from Brussels found how cancer cells protect themselves from the aggressive treatment.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Cancer cells have an innate randomness in their ability to respond to chemotherapy, which is another tool in their arsenal of resisting treatment, new research shows.
Scientists from Japan demonstrated, for the first time, a successful chemogenetic suppression of widespread epileptic seizures in macaque monkeys. Their findings represent an essential step towards clinical trials, and effective treatment for patients with severe epilepsy.
A Korean research team successfully changed the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.
Focused ultrasound (FUS) ablation is an emerging treatment for breast tumours. Its use was highlighted in an October webinar focused on emerging immunotherapy research and breast cancer.
Swedish researchers have developed a method that should be able to predict whether a patient with breast cancer will benefit from a particular treatment or not.
Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.
Scientists managed to identify and kill breast cancer cells that evade standard treatments in a study in mice. The is a step towards the development of new treatments to prevent relapse in patients.
Glioblastomas march to the beat of a different drum: researchers discovered a type of cells that act as pacemakers, driving the growth of the brain tumour and increasing its resistance.
An international research team has provided valuable new information about what drives the global spread of genes responsible for antimicrobial resistance (AMR) in bacteria.
A pioneering ‘smart contact lens’ to test the eye in a quick, non-invasive way could prevent deaths caused by fungal eye infections in developing countries.
Eunsin Bae, M.D. specializes in laboratory medicine and leads the Institute of Clinical Research at Seegene Inc. Her research focuses on microbiology, molecular biology, and hematology. Dr. Bae is currently working toward implementing a global clinical study and establishing an international network of clinical investigations.
A new Oxford University study provides the first direct evidence of antibiotic resistant bacteria migrating from a patient’s gut microbiome to the lungs, increasing the risk of deadly infections.
Periprosthetic infections and revisions are on the rise in Germany and worldwide, with significant consequences for affected patients as well as for the healthcare systems. Precisely because the number of patients at higher risk of infection in arthroplasty continues to rise, attention is increasingly focused on how this dreaded complication can be avoided.
It is the size of a common pencil eraser, but it could have a huge impact on the therapy of glioblastoma: Scientists in Virginia have developed a novel 3D tissue-engineered model of the brain tumour microenvironment, which can be used to assess how the glioma cell invades healthy tissue, proliferates, and reacts to chemotherapy drugs.
Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models.
With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.
Colorectal cancer is one of the most common cancers. A team from the University of Geneva has found an alternative for patients who have developed resistance to chemotherapy treatments.
As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.
Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.
Cambridge scientists have discovered that cancer cells ‘hijack’ a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.
What will the next pandemic look like? Health officials from across the globe gathered in Geneva in late August at a World Health Organization meeting to focus on how lessons learned from Covid-19 might best prepare civilization for the "next one."
Alveolar rhabdomyosarcoma is a rare pediatric tumor. For more than 40 years there has not been any new development regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now identified a new therapeutic option, using a drug that is currently under investigation for other types of cancer.
UC San Francisco researchers have developed a drug marking cancer cells for destruction by the immune system.
A new study could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis, are resistant to antibiotics.
German researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases such as Alzheimer's.
Researchers discovered that cancer cells mobilize a SOS response when they are desperate to resist anticancer drugs. The team also came up with an anti-SOS approach that blocked the mechanism in mice.
A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.
Avian flu, MERS, Covid-19, monkeypox: outbreaks of infectious diseases are getting more common in Europe. As a result, the EU must adapt its surveillance strategies and introduce more data-driven, interdisciplinary countermeasues.
Hospital patients who develop infections where 10% of sufferers die will be offered double the traditional course of antibiotics in a new trial.
The Covid-19 pandemic has highlighted the importance of the fast and accurate diagnosis of infectious diseases in clinical settings. Harald Maier discusses the implementation of rapid molecular diagnostics in the central clinical diagnostics laboratory at Innklinikum Altötting and Mühldorf, highlighting how the use of PCR testing has benefitted the hospital during the Covid-19 pandemic.
A Stanford mechanical engineer creates multifunctional wireless robots to maximize health outcomes and minimize invasiveness of procedures.
Over the last 50 years, malaria parasites have developed resistance to seven drugs, but a new way to identify future antimalarials holds promise.
Latest developments in computational protein design enable the simulation of sequence and structural changes in proteins for creating novel agents in human medicine.
Hospital-acquired infections are dangerous for patients and costly for clinics. A novel surface treatment could help improve the safety of medical devices and ease the economic burden.
A new way of differentiating healthy from diseased cells could pave the way for more personalised treatment for patients diagnosed with glioblastoma multiforme (GBM), a common and aggressive type of brain tumour.
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
A team of researchers from Singapore has developed a novel magnetic therapy that serves as an effective companion therapy to chemotherapy to enhance treatment outcome for breast cancer.
Climate change and antimicrobial resistance (AMR) are forming an alarming alliance: Global warming creates new breeding grounds for resistant bacteria. A serious and very real threat to public health – but not quite the doomsday scenario some might make it out to be, says Prof Sabiha Essack from the University of KwaZulu-Natal in Durban, South Africa.
Finding the right antibiotic dose is akin to a Goldilocks problem: give too little, and the infection will persist; too much, and side-effects will override the benefits of the therapy. To get it “just right”, Prof Dr Birgit Koch talks about dosing optimisation in the clinical setting.
When treating acute infections, health care providers must quickly identify the best antibiotics for fighting the infection. An automated system provides swift, accurate results for determining the best antibiotics at the right dose.
In the human intestine, Escherichia coli is mostly harmless, but in certain conditions causes bladder infections and even sepsis - but why? Researchers went to the bottom of this transformation.
Modern medicine offers “peel and stick” solutions like nicotine or contraceptive patches to put right on the skin without needing to visit a doctor for an injection or procedure. Now, researchers have found that applying a topical ointment containing anti-tumor factor can increase the effectiveness of cancer treatment.
Scientists from Hokkaido University have identified new targets for treating Adult T-cell leukemia/lymphoma (ATLL), an aggressive form of blood cancer with existing drugs.
Researchers find that drug-resistant bacteria can be distinguished from non-resistant bacteria based on structural changes evident in electron microscope images with high accuracy using deep learning.
Liquid profiling is offering clear benefits in terms of cancer diagnostics and targeted therapy, but challenges remain in bringing it into the clinic.
A newly discovered structure of chain-mail may explain the success of C.difficile at defending itself against antibiotics and immune system molecules.
Mathematical models used as patient surrogates could help clinicians select the best cancer treatment before going to the patient’s bedside.
Researchers have identified a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome.
The long-term impact of the coronavirus pandemic on antimicrobial resistance remains difficult to predict. Infectious diseases consultant Professor Alison Holmes reflects on Covid-19's effect on antibiotic use in hospitals and beyond.
Mark Nicholls reports from the National Cancer Research Institute (NCRI) virtual Festival, with four expert speakers discussing the role of liquid biopsy in cancer detection.
A worldwide consortium aims to equip researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens.
To counteract the spread of resistant germs, researchers have developed new drug candidates that are able to render one of the most important hospital germs harmless.
The Zybio EXS2600 mass spectrometry system enables rapid microbial identification, including bacteria and fungi. With an advanced pre-filled sample kit, user-friendly software and a comprehensive strain database, the EXS2600 offers high-throughput screening, convenient operation and accurate results.
Researchers at the University of Rochester, and Delft University of Technology in the Netherlands recently developed a 3D printing technique to engineer and study biofilms—three-dimensional communities of microorganisms, such as bacteria, that adhere to surfaces. The research provides important information for creating synthetic materials and in developing drugs to fight the negative effects of…
In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients. Scientists at the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and the National Center for…
A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.
Experts predict that without intervention, the problem of multidrug-resistant bacterial infections could be catastrophic by 2050, killing nearly 10 million people each year.
Researchers have found that regular blood tests can help detect whether prostate cancer patients have resistance to drugs treating the condition. The findings were presented at the National Cancer Research Institute (NCRI) virtual Festival.
Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.
For nuclear medicine specialists, 2021 may be heralded as a banner year validating the use of theranostic technology to treat cancer. Long-awaited results from the international phase 3 clinical VISION trial spark confidence in many experts.
An innovative collaboration has been formed in the UK between academic researchers and industry to develop a rapid integrated liquid biopsy platform for early detection of recurrent breast cancer. Breast cancer specialists Professor Charles Coombes, who is Professor of Medical Oncology at Imperial College London (ICL), and Professor Jacqui Shaw, Head of the Department of Genetics and Genome…
Leading functional & smart textile manufacturer Asiatic Fiber Corporation (AFC) introduces advanced wearable technology for electronic muscle stimulation (EMS) and transcutaneous electrical nerve stimulation (TENS): (EMS module / E-massage module) of the iQmax® series at the international trade fair MEDICA 2021, which will be held in Germany from November 15th to 18th.
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M.…
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria’s ability to cause disease and repurposing it to attack harmful microbes instead.
Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term. In some cases the tumors disappeared completely, researchers at the University of Zurich (UZH) and University Hospital Zurich (USZ) have found. Their findings will now be tested in…
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
Infectious disease diagnostics are notoriously slow. The gold standard for laboratory diagnosis of bacterial and fungal infection involves growing the pathogen from a clinical specimen – an overnight event, or even longer. The healthcare focus is on improving the use of antibiotics for better patient outcomes and reducing the environmental pressures that drive antibiotic resistance. To impact…
A solid diagnosis has always been the first step on any patient’s journey to health. However, diagnostic categories are necessarily oversimplifications. In the last decades, medical professionals and scientists have begun to uncover the true variability in patients’ physiological and biochemical make-up that is the principal cause for individual variations in the way diseases present…
Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted. The polymer, developed by Prof. Dr. Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and Life Sciences Institute at the University of British Columbia, substantially diminished rejection of transplants in mice when…
A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin…
A newly targeted therapy could help millions of lung cancer patients worldwide keep their cancers from spreading, says an expert at Cleveland Clinic, on the occasion of World Lung Cancer Day. Dr. Khaled Hassan, of the Hematology and Medical Oncology Department at Cleveland Clinic, explains the concept of KRAS targeted therapy – and why the approach should not be mistaken for a cancer cure.
A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial.
Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in…
To advance anti-tuberculosis (TB) science and enable the progression of new, safe, and affordable treatment solutions for TB patients worldwide, a new consortium of 30 partners from 13 countries has officially launched. The 7-year, €185 million project called Unite4TB, aims to accelerate and improve the clinical evaluation of combinations of existing and novel drugs, with the goal of developing…
Cécile Geneviève is one of the few women who lead research and development (R&D) at a major company and her increasingly female team reflects women’s growing interest in the field. But while gender balance is an important criterion, it takes a broad palette of skills to innovate to alleviate pain for millions of patients, she explained in an interview with Healthcare in Europe.
A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at Leeds. The mutated form of the RAS protein has been referred to as the “Death Star” because of its ability to resist treatments and is found in 96% of pancreatic cancers and 54% of colorectal cancers. RAS is a protein important for health but in its mutated form it can…
Researchers at RMIT University in Australia have developed smart wound dressings with built-in nanosensors that glow to alert patients when a wound is not healing properly. The multifunctional, antimicrobial dressings feature fluorescent sensors that glow brightly under UV light if infection starts to set in and can be used to monitor healing progress.
A new project led by University of California San Diego Biological Sciences graduate student Joshua Borin has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria.
Mining the world's most comprehensive drug repurposing collection for Covid-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.
Switching off a heart muscle protein could provide a new way for drugs to combat heart failure in people who’ve had a heart attack, according to research led by the University of Cambridge and published in the journal Nature. There is an unmet need to find drugs that can successfully improve the heart’s ability to pump blood efficiently after it’s been damaged following a heart attack.…
For the first time, a prospective, international study has shown that chest pain caused by problems with the very small vessels supplying blood to the heart is an important health problem that increases the risk of heart attacks, stroke and death due to cardiovascular reasons. The study, which is published in the European Heart Journal, recruited 686 patients from 14 institutions in seven…
By 2030, the most lethal form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is projected to become the second leading cause of cancer-related deaths in the United States. Not only are therapeutic options limited, but nearly half of PDAC patients who have their tumors removed surgically experience disease recurrence within a year, even with chemotherapy. For more advanced stages,…
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
Researchers used AI to identify which daily changing clinical parameters best predict intervention responses in critically ill Covid-19 patients. The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve…
Antibiotic resistant bacteria are a looming super threat – heralding a time when our drugs will no longer be effective against prevalent infections. Hospitals are already coping with treatment-resistant bacterial infections. Cognizant of the threat and thinking outside the box, BGU scientists and German and American colleagues have developed a pair of 'molecular tweezers' to destroy the biofilm…
Should outdoor face covering be normalised to reduce transmission of SARS-CoV-2—or should anti-Covid efforts rather focus on indoor protection? Experts argue the case for both sides in this controversial debate.
Diagnostic data from the massive amounts of testing being conducted can help make health systems more resilient in dealing with future health crises and pandemics. The importance of diagnostic data was explored during the Medtech Europe online session, “Unlocking the Value of Diagnostic Information – how to make European Health Systems more resilient?” where delegates heard that…
Researchers from Tel Aviv University have created an artificial intelligence platform that can identify the specific proteins that allow bacteria to infect the intestines.
With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs. A team of researchers at the College of Medicine at the University of Oklahoma has published a new study in the journal…
The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to a new report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria.…
An increasing number of bacterial pathogens are resistant to antibiotics. And the most dangerous pathogens share a common feature: a double membrane that is difficult to penetrate. Even when antibiotic agents are able to break into this shell, the bacteria just pump them right out again. But a recently discovered compound called Darobactin manages to circumvent these protective measures and kill…
A consortium of researchers from Russia, Belarus, Japan, Germany and France led by the Skolkovo Institute of Science and Technology have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.
An innovative hydrogel – called a double network (DN) gel – can rapidly reprogram differentiated cancer cells into cancer stem cells, researchers at Hokkaido University and the National Cancer Center Research Institute have reported in the journal Nature Biomedical Engineering. The hydrogel can be used to help develop new cancer therapies and personalized medicines targeting cancer stem cells.
Intrahepatic cholangiocarcinoma (ICC) develops within the liver. With one to two cases per 100,000 inhabitants in Germany, ICC is one of the rare diseases overall, but it is the second most common liver cancer. The aggressive bile duct tumour remains clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited…
Researchers have developed an innovative method to disrupt the formation of biofilms and thus facilitate the treatment of infections with Pseudomonas aeruginosa.
Bacteria have many ways to evade the antibiotics that we use against them. Each year, at least 2.8 million people in the United States develop an antibiotic-resistant infection, and more than 35,000 people die from such infections, according to the U.S. Centers for Disease Control. Most of the mutations known to confer resistance occur in the genes targeted by a particular antibiotic. Other…
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth, paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing. Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto (U of T), showed that chemically inhibiting the enzyme PRMT5 can…
Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…
Researchers from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes…
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles' heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
New high-resolution structures of the bacterial ribosome determined by researchers at the University of Illinois Chicago show that a single water molecule may be the cause — and possible solution — of antibiotic resistance. The findings of the new study are published in the journal Nature Chemical Biology. Pathogenic germs become resistant to antibiotics when they develop the ability to…
There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that…
Researchers at Karolinska Institutet have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect – even if the virus mutated. According to the researchers, the…
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance.
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body. Since colonoscopies were introduced in Germany for early cancer detection, the number of diagnoses of advanced cancer every year has decreased, as precancerous lesions can now be…
In recent years, targeted therapies have cemented their place as some of the most important tools in cancer treatment. These medicines are designed to block specific signals that tumor cells use to grow and spread, while at the same time leaving normal cells unharmed. Targeted therapies can significantly extend patients’ lives, but the benefits are often only temporary. Over time, many cancers…
For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a matter of weeks to months.
Scientists cannot be expected to drop everything they’re working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe. Speaking before he delivered the prestigious Michel Clavel lecture to the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which was due to take place…
Researchers have found that a class of commonly-used heart drugs may also improve patients’ responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics.
The fight against bacterial infections, especially those caused by resistant pathogens, is in full swing with the search for new antibiotic agents. The aim is to identify substances that attack the pathogens in a truly novel way. The team at the Center for Systems-Based Antibiotic Research (Cesar) at Ruhr-Universität Bochum (RUB) has described in two publications how assess if a new antibiotic…
A team at Purdue University has developed a novel testing platform to evaluate how breast cancer cells respond to the recurrent stretching that occurs in the lungs during breathing. The technology is designed to better understand the effects that the local tissue has on metastatic breast cancer to study how metastases grow in a new tissue.
A unique, ground-breaking global campaign, which has seen major pharmaceutical companies unite to fight antibiotic resistant infections, has been launched with a one-billion-dollar investment fund. The Antimicrobial Resistance (AMR) Action Fund aims to help save the collapsing antibiotic pipeline and make 2-4 new antibiotics available within a decade.
Researchers at the University of Sheffield have developed a new compound that is able to kill both gram-positive and gram-negative antibiotic-resistant bacteria.
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.
To answer medical questions that can be applied to a wide patient population, machine learning models rely on large, diverse datasets from a variety of institutions. However, health systems and hospitals are often resistant to sharing patient data, due to legal, privacy, and cultural challenges. An emerging technique called federated learning is a solution to this dilemma, according to a study…
A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast cancers. Around three quarters of women who have breast cancer have what are known as oestrogen…
Scientists from the German Cancer Research Center (DKFZ) and the Universities of Cambridge and Edinburgh have been studying the evolution of tumors following chemical damage. They discovered that the DNA lesions caused by the chemical are not eliminated immediately, but are passed on unrepaired over several rounds of cell division. This "lesion segregation" can drive unexpectedly…
Resistance of cancer cells against therapeutic agents is a major cause of treatment failure, especially in recurrent diseases. An international team around the biochemists Robert Ahrends from the University of Vienna and Jan Medenbach from the University of Regensburg identified a novel mechanism of chemoresistance which has now been published in "Nature Communications". It is driven by…
University of Melbourne researchers are finding ways to beat dangerous superbugs with ‘resistance resistant’ antibiotics, and it could help in the fight against coronavirus (COVID-19) complications. As bacteria evolve, they develop strategies that undermine antibiotics and morph into ‘superbugs’ that can resist most available treatments and cause potentially lethal infections. The…
In order for a COVID-19 vaccine and antiviral drugs to be developed, scientists first need to understand why this virus spreads so easily and quickly, and why it invades our bodies with seemingly little resistance from our immune system. To understand how COVID-19 enters the body and does its damage, a team of top researchers from universities, hospitals and the National Research Council of…
As coronavirus disease COVID-19 continues to jet and alight invisibly around the globe, scientists now report that the virus has mutated to become two strains: the older ‘S-type’ appears milder and less infectious, while the later-emerging ‘L-type’, is more aggressive, spreads more quickly, and currently accounts for about 70 per cent of cases. Worldwide, medical researchers are exploring…
Eric Prossnitz, PhD, from the University of New Mexico Health Services and his team hope to help 93 million obese Americans fight their fat. In a paper published in Science Translational Medicine, they reported that G-1, a cancer-fighting compound they discovered some years ago, reduces fat in obese mice. Although G-1 is currently in phase 1 clinical trials for cancer, Prossnitz and his team are…
In their quest to find new and better methods to make cancer cells more susceptible to treatment, Karin Lindkvist and her research group at Lund University in Sweden are looking into the world of molecules, using the X-rays at the MAX IV laboratory. The researchers believe that limiting the cells' access to sugar will make cancer cells more sensitive to treatment. Many of the cancer treatments…
A probiotic drink could become a promising new weapon in the battle against antibiotic resistant bacteria, after a team of scientists at the University of Birmingham engineered and patented a key genetic element that can tackle the genetic basis of resistance. The team is now seeking funding for a clinical trial for the drink which has potential to work against many resistant bacteria commonly…
A team of physicists from McMaster University has developed a process to modify red blood cells so they can be used to distribute drugs throughout the body, which could specifically target infections or treat catastrophic diseases such as cancer or Alzheimer’s. The modified red blood cells are designed to circulate in the body for several weeks at a time, seeking out specific targets including…
Researchers at Lund University in Sweden have developed a new hydrogel based on the body’s natural peptide defense. It has been shown to prevent and treat infections in wounds. The formulation kills multi-resistant bacteria, something that is increasing in importance with antibiotic resistance growing globally. “The ability to effectively heal wounds is key for our survival in evolutionary…
Researchers say a new method to analyse data from individual human cells could be a step-change for diagnosing some of the most devastating diseases, including cancer and autoimmune disease. By combining single cell analysis techniques with machine learning algorithms, a team led by researchers at the Garvan Institute of Medical Research has developed a method to ‘fingerprint’ human cells.…
A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new University of Liverpool research warns. Published in the journal mBio, the findings highlight the need to develop new drugs and treatment regimens for the lethal brain infection, which kills around 180,000 people each year. Cryptococcal…
The U.S. Food and Drug Administration (FDA) announced the global launch of Cure ID, an internet-based repository that will allow the clinical community to report their experiences treating difficult-to-treat infectious diseases with novel uses of existing FDA-approved drugs through a website, a smartphone or other mobile device. The platform enables the crowdsourcing of medical information from…
Research led by scientists from McMaster University has yielded a potent antimicrobial that works against the toughest infectious disease strains. The find could be the beginning of developing new therapeutics to combat drug-resistant infections. The discovery is important as it is directly related to the development of Staphylococcus aureus diseases, known popularly as staph infections, which…
T2 Biosystems, Inc., a leader in the development and commercialization of medical diagnostic products, and CARB-X, a global non-profit partnership dedicated to accelerating R&D innovation to address the rising global threat of drug-resistant bacteria, announced the granting of a CE mark to the T2Resistance Panel. With the CE mark, T2 Biosystems has met the requirements of the In-Vitro…
Antibiotic-resistant pathogens pose one of the greatest threats to public health worldwide. In the near future, harmless bacterial infections may no longer be treatable and may again become the most common non-natural cause of death. At the same time, the available repertoire of antibacterial agents is becoming increasingly smaller as resistance rates rise.
PHE’s latest English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) report shows that there were an estimated 61,000 antibiotic resistant infections in England during 2018, a 9 percent rise from 2017.[i]
Teams of researchers from Charité – Universitätsmedizin Berlin and the Medical University of Innsbruck have developed a new therapeutic concept for the treatment of temporal lobe epilepsy. It represents a gene therapy capable of suppressing seizures at their site of origin on demand. Having been shown to be effective in an animal model, the new method will now be optimized for clinical use.…
Scientists from Scotland are developing a low cost, rapid diagnostic sensor test which aims to show the susceptibility of bacteria to antibiotics within 45 minutes. Laboratory testing of samples can take up to two days and the new test aims to allow doctors to be able to prescribe the correct antibiotic to a patient for an infection more quickly. In a research paper published in the journal…
A team of researchers lead by Helmholtz Zentrum München and the University of Würzburg identified an enzyme as a novel and strong inhibitor of ferroptosis, the iron dependent form of cell death: ferroptosis suppressor protein-1, short FSP1. This protein is expressed in a variety of cancer cell lines and therefore represents an attractive drug target for cancer treatment.
Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients. Helicobacter pylori is a bacterial pathogen carried by 4.4 billion people worldwide, with the highest prevalence in Africa, Latin America and the Caribbean. Although the majority of infections show no symptoms,…
A study by a team of Victoria University of Wellington scientists spotlights the role of gene networks in how people respond to one of the world’s most prescribed medications. The research team investigated the genetic network response to cholesterol-lowering drugs called statins, a medication prescribed to about 30 million people worldwide. The researchers say it is a significant step towards…
For decades now, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing processes and systems for cleaning, sterilization, and surface modification. The newly in-house developed process, called SULEEI, makes it possible to sterilize (S) and preserve decellularized pericardial tissue by means of photo-initiated ultraviolet (U) crosslinking…
T2 Biosystems and CARB-X announced that the T2Resistance Panel is the first diagnostic to graduate from CARB-X’s portfolio.
A person with drug resistant epilepsy who gets an early surgical intervention has a better chance of becoming seizure free. This is shown in a systematic review and meta-analysis in which Sahlgrenska Academy researchers, in collaboration with the Swedish Council for Assessment of Health Technology and Social Services (SBU), analysed results from a range of previous studies. They concluded that…
Researchers identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau hereditary cancer. In a recent publication in PNAS, the research group identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau (VHL) hereditary cancer.
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of Staphylococcus aureus – a microbe present in 30-60% of the global population and responsible for many diseases, some fatal – more invasive and persistent, although the effect is not universal across all…
Researchers at the University of Birmingham have shown that it’s possible to produce a compound with anti-cancer properties directly from feverfew – a common flowering garden plant. The team was able to extract the compound from the flowers and modify it so it could be used to kill chronic lymphocytic leukaemia (CLL) cells in the laboratory. Feverfew is grown in many UK gardens, and also…
New research has found that antibiotic-resistant strains of Klebsiella pneumoniae, an opportunistic pathogen that can cause respiratory and bloodstream infections, are spreading through hospitals in Europe. Certain strains are resistant to the carbapenem antibiotics that represent the last line of defence in treating infections and are therefore regarded as extremely drug resistant (XDR).
Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast. But often what ails us is inside the body and is not so easy to reach. In such cases, a treatment like surgery or chemotherapy might be called for. A pair of researchers in Caltech's Division of Engineering and…
Global warming may have played a pivotal role in the emergence of Candida auris. According to a new study published in mBio, an open-access journal of the American Society for Microbiology, C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change.
The World Health Organisation's (WHO) Essential Medicines List and List of Essential Diagnostics are core guidance documents that help countries prioritize critical health products that should be widely available and affordable throughout health systems. Now, updated versions of the two lists have been published, focusing on cancer and other global health challenges, with an emphasis on effective…
Many countries across the world are challenged with a rising number of incidences of multi-drug resistant (MDR) organisms infecting the population, and for several years, a clear pattern of increased resistance has emerged in southern and eastern European countries. For example, in countries such as Italy, a reduced number of therapeutic options remain available for highly pathogenic infections,…
Cancers with the same genetic weaknesses respond differently to targeted drugs depending on the tumour type of the patient, new research reveals. The study is set to prompt changes in thinking around precision medicine—because it shows that the genetics of a patient's cancer may not always be enough to tell whether it will respond to a treatment. The researchers are already starting to design…
As leaders gather for the International Ministerial Conference on antimicrobial resistance (AMR), hosted by the government of The Netherlands and organised in close cooperation with the FAO, OIE and WHO, experts and responsible manufacturers are calling for a 'One Health' approach to AMR and recognition of the impact of antibiotic production on the environment. "With two thirds of the worlds…
Immuno-oncology is a therapy in which the body’s immune system treats a tumour. Dr Eric Borges, from the Research and Development Centre at Boehringer Ingelheim Pharma GmbH in Germany, explains why this is revolutionary. Unlike conventional cancer therapies, with immuno-oncology the tumour cell is not the direct target, it’s the patient’s immune system. The medication stimulates this to…
Wilmot Cancer Institute scientists believe they have figured out why a commonly used drug to treat late-stage prostate cancer often stops working after four or five months and appears to have a dual function that later turns the cancer into a relentless aggressor.
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many…
Imperial medical students have helped to devise a new type of ‘decoy’ drug to tackle infections that are resistant to antibiotics. In lab tests on bacterial cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden. When the bacteria fight against the first ‘decoy’ antibiotic, this action…
High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumors consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment. Over half of the patients…
Early detection and confirmation of carbapenemase-producing enterobacteriaceae (CPE) are essential when choosing the appropriate antimicrobial therapy and to implement infection control measures. Here, a leading Spanish microbiologist reviews an arsenal of tools currently available to clinicians. Resistance to beta-lactam antibiotics in enterobacteriaceae (EBc) is due to one or more of these…
Antimicrobial resistance is a global issue, with 700,000 deaths per year and 10 million expected deaths by 2050, according to predictions. Appropriate antimicrobial therapy can help to save lives, and a long awaited cure for carbapenemase-producing enterobacteriaceae (CPE) will soon be released, according to eminent Spanish expert Jose Mensa Pueyo, speaking at a Madrid meeting in March. The past…
Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of chordomas in advanced stages after conducting gene analysis. Their findings, published in the journal Nature…
For some cancers, initial treatment with chemotherapy brings positive, but only temporary, results: tumors shrink, but then rebound as the cancer becomes drug-resistant. This pattern of remission-resistance-relapse is particularly true for pancreatic cancer, an aggressive disease in which early success is often countered by eventual disease progression. To wit: The one-year relative survival rate…
Why do cancer cells react differently to treatments? Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy. In a Nature Communications paper, researchers reveal for the first time that the number of mitochondria in a cell is, in great part, associated with how the cancer responds to drug…
It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones.
A minimally invasive procedure to determine whether patients with drug-resistant epilepsy are candidates for brain surgery is safer, more efficient, and leads to better outcomes than the traditional method, according to new research by The University of Texas Health Science Center at Houston (UTHealth).
