Cedars-Sinai Medical Center, a non-profit hospital and medical research institution in Los Angeles, is setting new standards for quality and innovation in patient care by successfully introducing typing of Candida auris species – a procedure that could prove crucial in protecting patients from infection outbreaks caused by these microbes in healthcare settings.
Assays: Clozapine, Risperidone, Aripiprazole, Olanzapine, Quetiapine, Paliperidone Highlights:Antipsychotic drug monitoring provides healthcare professionals accurate and vital information.Testing of antipsychotic drugs can help manage patient therapy by providing greater clarity on the causes of treatment failure (i.e., adherence, drug resistance, drug-drug interactions and drug…
A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.
A new study on public health communication shows that the term commonly used to describe bacteria resistant to current medicines or antibiotics fails to stick in people’s memories.
A team of researchers from Vienna has discovered that dormant breast cancer tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein.
US researchers have discovered that radiation therapy combined with two types of immunotherapy can control tumors in preclinical models of triple negative breast cancer.
A new class of antibiotics, based on proven drugs used in cancer treatment, is now being developed by researchers at Linköping University. They could be used against resistant bacteria.
US researchers identified a potential breakthrough in glioblastoma treatment. Using a modified virus, they created a treatment that specifically attacks tumor cells, while leaving normal cells intact.
Governments around the world must do more to tackle the growing threat of drug-resistant infections, new research led by the University of Leeds suggests.
AI could find critical biomarkers that predict non-response to conventional treatment in patients with chronic myeloid leukaemia (CML) more quickly, researchers in Singapore find.
Tumors sometimes seem to take on a life of their own, with cancer genes “striking out” in ring shapes. An international research team has new insights into this phenomenon.
Newly developed “smart” coatings for surgical orthopedic implants can monitor strain on the devices to provide early warning of implant failures while killing infection-causing bacteria.
Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the chemotherapy of testicular cancer.
When in doubt, write a prescription? New research links burnout in GPs to higher antibiotic and strong opioid prescribing, especially in more deprived areas of the North of England.
Chemotherapy resistance is a main cause of treatment failure and death in cancer patients. Researchers from Brussels found how cancer cells protect themselves from the aggressive treatment.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Cancer cells have an innate randomness in their ability to respond to chemotherapy, which is another tool in their arsenal of resisting treatment, new research shows.
Scientists from Japan demonstrated, for the first time, a successful chemogenetic suppression of widespread epileptic seizures in macaque monkeys. Their findings represent an essential step towards clinical trials, and effective treatment for patients with severe epilepsy.
A Korean research team successfully changed the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.
Focused ultrasound (FUS) ablation is an emerging treatment for breast tumours. Its use was highlighted in an October webinar focused on emerging immunotherapy research and breast cancer.
Swedish researchers have developed a method that should be able to predict whether a patient with breast cancer will benefit from a particular treatment or not.
Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.
Scientists managed to identify and kill breast cancer cells that evade standard treatments in a study in mice. The is a step towards the development of new treatments to prevent relapse in patients.
Glioblastomas march to the beat of a different drum: researchers discovered a type of cells that act as pacemakers, driving the growth of the brain tumour and increasing its resistance.
An international research team has provided valuable new information about what drives the global spread of genes responsible for antimicrobial resistance (AMR) in bacteria.
A pioneering ‘smart contact lens’ to test the eye in a quick, non-invasive way could prevent deaths caused by fungal eye infections in developing countries.
Eunsin Bae, M.D. specializes in laboratory medicine and leads the Institute of Clinical Research at Seegene Inc. Her research focuses on microbiology, molecular biology, and hematology. Dr. Bae is currently working toward implementing a global clinical study and establishing an international network of clinical investigations.
A new Oxford University study provides the first direct evidence of antibiotic resistant bacteria migrating from a patient’s gut microbiome to the lungs, increasing the risk of deadly infections.
Periprosthetic infections and revisions are on the rise in Germany and worldwide, with significant consequences for affected patients as well as for the healthcare systems. Precisely because the number of patients at higher risk of infection in arthroplasty continues to rise, attention is increasingly focused on how this dreaded complication can be avoided.
It is the size of a common pencil eraser, but it could have a huge impact on the therapy of glioblastoma: Scientists in Virginia have developed a novel 3D tissue-engineered model of the brain tumour microenvironment, which can be used to assess how the glioma cell invades healthy tissue, proliferates, and reacts to chemotherapy drugs.
Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models.
With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.
Colorectal cancer is one of the most common cancers. A team from the University of Geneva has found an alternative for patients who have developed resistance to chemotherapy treatments.
As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.
Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.
Cambridge scientists have discovered that cancer cells ‘hijack’ a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.
What will the next pandemic look like? Health officials from across the globe gathered in Geneva in late August at a World Health Organization meeting to focus on how lessons learned from Covid-19 might best prepare civilization for the "next one."
Alveolar rhabdomyosarcoma is a rare pediatric tumor. For more than 40 years there has not been any new development regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now identified a new therapeutic option, using a drug that is currently under investigation for other types of cancer.
UC San Francisco researchers have developed a drug marking cancer cells for destruction by the immune system.
A new study could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis, are resistant to antibiotics.
German researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases such as Alzheimer's.
Researchers discovered that cancer cells mobilize a SOS response when they are desperate to resist anticancer drugs. The team also came up with an anti-SOS approach that blocked the mechanism in mice.
A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.
Avian flu, MERS, Covid-19, monkeypox: outbreaks of infectious diseases are getting more common in Europe. As a result, the EU must adapt its surveillance strategies and introduce more data-driven, interdisciplinary countermeasues.
Hospital patients who develop infections where 10% of sufferers die will be offered double the traditional course of antibiotics in a new trial.
The Covid-19 pandemic has highlighted the importance of the fast and accurate diagnosis of infectious diseases in clinical settings. Harald Maier discusses the implementation of rapid molecular diagnostics in the central clinical diagnostics laboratory at Innklinikum Altötting and Mühldorf, highlighting how the use of PCR testing has benefitted the hospital during the Covid-19 pandemic.
A Stanford mechanical engineer creates multifunctional wireless robots to maximize health outcomes and minimize invasiveness of procedures.
Over the last 50 years, malaria parasites have developed resistance to seven drugs, but a new way to identify future antimalarials holds promise.
Latest developments in computational protein design enable the simulation of sequence and structural changes in proteins for creating novel agents in human medicine.
Hospital-acquired infections are dangerous for patients and costly for clinics. A novel surface treatment could help improve the safety of medical devices and ease the economic burden.
A new way of differentiating healthy from diseased cells could pave the way for more personalised treatment for patients diagnosed with glioblastoma multiforme (GBM), a common and aggressive type of brain tumour.
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
A team of researchers from Singapore has developed a novel magnetic therapy that serves as an effective companion therapy to chemotherapy to enhance treatment outcome for breast cancer.
Climate change and antimicrobial resistance (AMR) are forming an alarming alliance: Global warming creates new breeding grounds for resistant bacteria. A serious and very real threat to public health – but not quite the doomsday scenario some might make it out to be, says Prof Sabiha Essack from the University of KwaZulu-Natal in Durban, South Africa.
Finding the right antibiotic dose is akin to a Goldilocks problem: give too little, and the infection will persist; too much, and side-effects will override the benefits of the therapy. To get it “just right”, Prof Dr Birgit Koch talks about dosing optimisation in the clinical setting.
When treating acute infections, health care providers must quickly identify the best antibiotics for fighting the infection. An automated system provides swift, accurate results for determining the best antibiotics at the right dose.
In the human intestine, Escherichia coli is mostly harmless, but in certain conditions causes bladder infections and even sepsis - but why? Researchers went to the bottom of this transformation.
Modern medicine offers “peel and stick” solutions like nicotine or contraceptive patches to put right on the skin without needing to visit a doctor for an injection or procedure. Now, researchers have found that applying a topical ointment containing anti-tumor factor can increase the effectiveness of cancer treatment.
Scientists from Hokkaido University have identified new targets for treating Adult T-cell leukemia/lymphoma (ATLL), an aggressive form of blood cancer with existing drugs.
Researchers find that drug-resistant bacteria can be distinguished from non-resistant bacteria based on structural changes evident in electron microscope images with high accuracy using deep learning.
Liquid profiling is offering clear benefits in terms of cancer diagnostics and targeted therapy, but challenges remain in bringing it into the clinic.
A newly discovered structure of chain-mail may explain the success of C.difficile at defending itself against antibiotics and immune system molecules.
Mathematical models used as patient surrogates could help clinicians select the best cancer treatment before going to the patient’s bedside.
Researchers have identified a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome.
The long-term impact of the coronavirus pandemic on antimicrobial resistance remains difficult to predict. Infectious diseases consultant Professor Alison Holmes reflects on Covid-19's effect on antibiotic use in hospitals and beyond.
Mark Nicholls reports from the National Cancer Research Institute (NCRI) virtual Festival, with four expert speakers discussing the role of liquid biopsy in cancer detection.
A worldwide consortium aims to equip researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens.
To counteract the spread of resistant germs, researchers have developed new drug candidates that are able to render one of the most important hospital germs harmless.
The Zybio EXS2600 mass spectrometry system enables rapid microbial identification, including bacteria and fungi. With an advanced pre-filled sample kit, user-friendly software and a comprehensive strain database, the EXS2600 offers high-throughput screening, convenient operation and accurate results.
Researchers at the University of Rochester, and Delft University of Technology in the Netherlands recently developed a 3D printing technique to engineer and study biofilms—three-dimensional communities of microorganisms, such as bacteria, that adhere to surfaces. The research provides important information for creating synthetic materials and in developing drugs to fight the negative effects of…
In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients. Scientists at the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and the National Center for…
A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.
Experts predict that without intervention, the problem of multidrug-resistant bacterial infections could be catastrophic by 2050, killing nearly 10 million people each year.
Researchers have found that regular blood tests can help detect whether prostate cancer patients have resistance to drugs treating the condition. The findings were presented at the National Cancer Research Institute (NCRI) virtual Festival.
Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.
For nuclear medicine specialists, 2021 may be heralded as a banner year validating the use of theranostic technology to treat cancer. Long-awaited results from the international phase 3 clinical VISION trial spark confidence in many experts.
An innovative collaboration has been formed in the UK between academic researchers and industry to develop a rapid integrated liquid biopsy platform for early detection of recurrent breast cancer. Breast cancer specialists Professor Charles Coombes, who is Professor of Medical Oncology at Imperial College London (ICL), and Professor Jacqui Shaw, Head of the Department of Genetics and Genome…
Leading functional & smart textile manufacturer Asiatic Fiber Corporation (AFC) introduces advanced wearable technology for electronic muscle stimulation (EMS) and transcutaneous electrical nerve stimulation (TENS): (EMS module / E-massage module) of the iQmax® series at the international trade fair MEDICA 2021, which will be held in Germany from November 15th to 18th.
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M.…
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria’s ability to cause disease and repurposing it to attack harmful microbes instead.
Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term. In some cases the tumors disappeared completely, researchers at the University of Zurich (UZH) and University Hospital Zurich (USZ) have found. Their findings will now be tested in…
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
Infectious disease diagnostics are notoriously slow. The gold standard for laboratory diagnosis of bacterial and fungal infection involves growing the pathogen from a clinical specimen – an overnight event, or even longer. The healthcare focus is on improving the use of antibiotics for better patient outcomes and reducing the environmental pressures that drive antibiotic resistance. To impact…
A solid diagnosis has always been the first step on any patient’s journey to health. However, diagnostic categories are necessarily oversimplifications. In the last decades, medical professionals and scientists have begun to uncover the true variability in patients’ physiological and biochemical make-up that is the principal cause for individual variations in the way diseases present…
Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted. The polymer, developed by Prof. Dr. Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and Life Sciences Institute at the University of British Columbia, substantially diminished rejection of transplants in mice when…
A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin…
A newly targeted therapy could help millions of lung cancer patients worldwide keep their cancers from spreading, says an expert at Cleveland Clinic, on the occasion of World Lung Cancer Day. Dr. Khaled Hassan, of the Hematology and Medical Oncology Department at Cleveland Clinic, explains the concept of KRAS targeted therapy – and why the approach should not be mistaken for a cancer cure.
A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial.
Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in…
To advance anti-tuberculosis (TB) science and enable the progression of new, safe, and affordable treatment solutions for TB patients worldwide, a new consortium of 30 partners from 13 countries has officially launched. The 7-year, €185 million project called Unite4TB, aims to accelerate and improve the clinical evaluation of combinations of existing and novel drugs, with the goal of developing…
Cécile Geneviève is one of the few women who lead research and development (R&D) at a major company and her increasingly female team reflects women’s growing interest in the field. But while gender balance is an important criterion, it takes a broad palette of skills to innovate to alleviate pain for millions of patients, she explained in an interview with Healthcare in Europe.
A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at Leeds. The mutated form of the RAS protein has been referred to as the “Death Star” because of its ability to resist treatments and is found in 96% of pancreatic cancers and 54% of colorectal cancers. RAS is a protein important for health but in its mutated form it can…
Researchers at RMIT University in Australia have developed smart wound dressings with built-in nanosensors that glow to alert patients when a wound is not healing properly. The multifunctional, antimicrobial dressings feature fluorescent sensors that glow brightly under UV light if infection starts to set in and can be used to monitor healing progress.
A new project led by University of California San Diego Biological Sciences graduate student Joshua Borin has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria.
Mining the world's most comprehensive drug repurposing collection for Covid-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.
Switching off a heart muscle protein could provide a new way for drugs to combat heart failure in people who’ve had a heart attack, according to research led by the University of Cambridge and published in the journal Nature. There is an unmet need to find drugs that can successfully improve the heart’s ability to pump blood efficiently after it’s been damaged following a heart attack.…
For the first time, a prospective, international study has shown that chest pain caused by problems with the very small vessels supplying blood to the heart is an important health problem that increases the risk of heart attacks, stroke and death due to cardiovascular reasons. The study, which is published in the European Heart Journal, recruited 686 patients from 14 institutions in seven…
By 2030, the most lethal form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is projected to become the second leading cause of cancer-related deaths in the United States. Not only are therapeutic options limited, but nearly half of PDAC patients who have their tumors removed surgically experience disease recurrence within a year, even with chemotherapy. For more advanced stages,…
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
Researchers used AI to identify which daily changing clinical parameters best predict intervention responses in critically ill Covid-19 patients. The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve…
Antibiotic resistant bacteria are a looming super threat – heralding a time when our drugs will no longer be effective against prevalent infections. Hospitals are already coping with treatment-resistant bacterial infections. Cognizant of the threat and thinking outside the box, BGU scientists and German and American colleagues have developed a pair of 'molecular tweezers' to destroy the biofilm…
Should outdoor face covering be normalised to reduce transmission of SARS-CoV-2—or should anti-Covid efforts rather focus on indoor protection? Experts argue the case for both sides in this controversial debate.
Diagnostic data from the massive amounts of testing being conducted can help make health systems more resilient in dealing with future health crises and pandemics. The importance of diagnostic data was explored during the Medtech Europe online session, “Unlocking the Value of Diagnostic Information – how to make European Health Systems more resilient?” where delegates heard that…
Researchers from Tel Aviv University have created an artificial intelligence platform that can identify the specific proteins that allow bacteria to infect the intestines.
With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs. A team of researchers at the College of Medicine at the University of Oklahoma has published a new study in the journal…
The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to a new report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria.…
An increasing number of bacterial pathogens are resistant to antibiotics. And the most dangerous pathogens share a common feature: a double membrane that is difficult to penetrate. Even when antibiotic agents are able to break into this shell, the bacteria just pump them right out again. But a recently discovered compound called Darobactin manages to circumvent these protective measures and kill…
A consortium of researchers from Russia, Belarus, Japan, Germany and France led by the Skolkovo Institute of Science and Technology have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a rubredoxin family that play an important role in adaptation to changing environmental conditions.
An innovative hydrogel – called a double network (DN) gel – can rapidly reprogram differentiated cancer cells into cancer stem cells, researchers at Hokkaido University and the National Cancer Center Research Institute have reported in the journal Nature Biomedical Engineering. The hydrogel can be used to help develop new cancer therapies and personalized medicines targeting cancer stem cells.
Intrahepatic cholangiocarcinoma (ICC) develops within the liver. With one to two cases per 100,000 inhabitants in Germany, ICC is one of the rare diseases overall, but it is the second most common liver cancer. The aggressive bile duct tumour remains clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited…
Researchers have developed an innovative method to disrupt the formation of biofilms and thus facilitate the treatment of infections with Pseudomonas aeruginosa.
Bacteria have many ways to evade the antibiotics that we use against them. Each year, at least 2.8 million people in the United States develop an antibiotic-resistant infection, and more than 35,000 people die from such infections, according to the U.S. Centers for Disease Control. Most of the mutations known to confer resistance occur in the genes targeted by a particular antibiotic. Other…
Inhibiting a key enzyme that controls a large network of proteins important in cell division and growth, paves the way for a new class of drugs that could stop glioblastoma, a deadly brain cancer, from growing. Researchers at Princess Margaret Cancer Centre, the Hospital for Sick Children (SickKids) and University of Toronto (U of T), showed that chemically inhibiting the enzyme PRMT5 can…
Researchers from the University of Nottingham have discovered a novel antiviral property of a drug that could have major implications in how future epidemics/pandemics – including Covid-19 – are managed. The study, published in Viruses, shows that thapsigargin is a promising broad‑spectrum antiviral, highly effective against SARS-CoV-2, a common cold coronavirus, respiratory syncytial virus…
Researchers from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes…
Researchers at Vanderbilt University Medical Center (VUMC) and the University of Texas Medical Branch (UTMB) at Galveston have discovered what may be the Achilles' heel of the coronavirus, a finding that may help close the door on COVID-19 and possibly head off future pandemics.
New high-resolution structures of the bacterial ribosome determined by researchers at the University of Illinois Chicago show that a single water molecule may be the cause — and possible solution — of antibiotic resistance. The findings of the new study are published in the journal Nature Chemical Biology. Pathogenic germs become resistant to antibiotics when they develop the ability to…
There is currently no cure for osteoarthritis, but a group of scientists believe they’ve discovered a method through which a simple knee injection could potentially stop the disease’s effects. These researchers showed that they could target a specific protein pathway in mice, put it into overdrive and halt cartilage degeneration over time. Building on that finding, they were able to show that…
Researchers at Karolinska Institutet have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect – even if the virus mutated. According to the researchers, the…
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance.
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body. Since colonoscopies were introduced in Germany for early cancer detection, the number of diagnoses of advanced cancer every year has decreased, as precancerous lesions can now be…
In recent years, targeted therapies have cemented their place as some of the most important tools in cancer treatment. These medicines are designed to block specific signals that tumor cells use to grow and spread, while at the same time leaving normal cells unharmed. Targeted therapies can significantly extend patients’ lives, but the benefits are often only temporary. Over time, many cancers…
For a slow-growing microbe that multiplies infrequently, Mycobacterium tuberculosis, the pathogen that causes tuberculosis (TB) has long puzzled researchers as to how it develops resistance to antibiotics so quickly, in a matter of weeks to months.
Scientists cannot be expected to drop everything they’re working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe. Speaking before he delivered the prestigious Michel Clavel lecture to the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which was due to take place…
Researchers have found that a class of commonly-used heart drugs may also improve patients’ responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics.
The fight against bacterial infections, especially those caused by resistant pathogens, is in full swing with the search for new antibiotic agents. The aim is to identify substances that attack the pathogens in a truly novel way. The team at the Center for Systems-Based Antibiotic Research (Cesar) at Ruhr-Universität Bochum (RUB) has described in two publications how assess if a new antibiotic…
A team at Purdue University has developed a novel testing platform to evaluate how breast cancer cells respond to the recurrent stretching that occurs in the lungs during breathing. The technology is designed to better understand the effects that the local tissue has on metastatic breast cancer to study how metastases grow in a new tissue.
A unique, ground-breaking global campaign, which has seen major pharmaceutical companies unite to fight antibiotic resistant infections, has been launched with a one-billion-dollar investment fund. The Antimicrobial Resistance (AMR) Action Fund aims to help save the collapsing antibiotic pipeline and make 2-4 new antibiotics available within a decade.
Researchers at the University of Sheffield have developed a new compound that is able to kill both gram-positive and gram-negative antibiotic-resistant bacteria.
Scientists at Nanyang Technological University, Singapore (NTU Singapore) have developed a synthetic peptide that can make multidrug-resistant bacteria sensitive to antibiotics again when used together with traditional antibiotics, offering hope for the prospect of a combination treatment strategy to tackle certain antibiotic-tolerant infections.
To answer medical questions that can be applied to a wide patient population, machine learning models rely on large, diverse datasets from a variety of institutions. However, health systems and hospitals are often resistant to sharing patient data, due to legal, privacy, and cultural challenges. An emerging technique called federated learning is a solution to this dilemma, according to a study…
A team of British and American scientists have discovered a way to slow the growth of breast cancer stem cells in the lab. The study led by Dr Bruno Simões and Professor Rob Clarke from The University of Manchester could eventually lead to combination drug therapies on previously untreatable breast cancers. Around three quarters of women who have breast cancer have what are known as oestrogen…
Scientists from the German Cancer Research Center (DKFZ) and the Universities of Cambridge and Edinburgh have been studying the evolution of tumors following chemical damage. They discovered that the DNA lesions caused by the chemical are not eliminated immediately, but are passed on unrepaired over several rounds of cell division. This "lesion segregation" can drive unexpectedly…
Resistance of cancer cells against therapeutic agents is a major cause of treatment failure, especially in recurrent diseases. An international team around the biochemists Robert Ahrends from the University of Vienna and Jan Medenbach from the University of Regensburg identified a novel mechanism of chemoresistance which has now been published in "Nature Communications". It is driven by…
University of Melbourne researchers are finding ways to beat dangerous superbugs with ‘resistance resistant’ antibiotics, and it could help in the fight against coronavirus (COVID-19) complications. As bacteria evolve, they develop strategies that undermine antibiotics and morph into ‘superbugs’ that can resist most available treatments and cause potentially lethal infections. The…
In order for a COVID-19 vaccine and antiviral drugs to be developed, scientists first need to understand why this virus spreads so easily and quickly, and why it invades our bodies with seemingly little resistance from our immune system. To understand how COVID-19 enters the body and does its damage, a team of top researchers from universities, hospitals and the National Research Council of…
As coronavirus disease COVID-19 continues to jet and alight invisibly around the globe, scientists now report that the virus has mutated to become two strains: the older ‘S-type’ appears milder and less infectious, while the later-emerging ‘L-type’, is more aggressive, spreads more quickly, and currently accounts for about 70 per cent of cases. Worldwide, medical researchers are exploring…
Eric Prossnitz, PhD, from the University of New Mexico Health Services and his team hope to help 93 million obese Americans fight their fat. In a paper published in Science Translational Medicine, they reported that G-1, a cancer-fighting compound they discovered some years ago, reduces fat in obese mice. Although G-1 is currently in phase 1 clinical trials for cancer, Prossnitz and his team are…
In their quest to find new and better methods to make cancer cells more susceptible to treatment, Karin Lindkvist and her research group at Lund University in Sweden are looking into the world of molecules, using the X-rays at the MAX IV laboratory. The researchers believe that limiting the cells' access to sugar will make cancer cells more sensitive to treatment. Many of the cancer treatments…
A probiotic drink could become a promising new weapon in the battle against antibiotic resistant bacteria, after a team of scientists at the University of Birmingham engineered and patented a key genetic element that can tackle the genetic basis of resistance. The team is now seeking funding for a clinical trial for the drink which has potential to work against many resistant bacteria commonly…
A team of physicists from McMaster University has developed a process to modify red blood cells so they can be used to distribute drugs throughout the body, which could specifically target infections or treat catastrophic diseases such as cancer or Alzheimer’s. The modified red blood cells are designed to circulate in the body for several weeks at a time, seeking out specific targets including…
Researchers at Lund University in Sweden have developed a new hydrogel based on the body’s natural peptide defense. It has been shown to prevent and treat infections in wounds. The formulation kills multi-resistant bacteria, something that is increasing in importance with antibiotic resistance growing globally. “The ability to effectively heal wounds is key for our survival in evolutionary…
Researchers say a new method to analyse data from individual human cells could be a step-change for diagnosing some of the most devastating diseases, including cancer and autoimmune disease. By combining single cell analysis techniques with machine learning algorithms, a team led by researchers at the Garvan Institute of Medical Research has developed a method to ‘fingerprint’ human cells.…
A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new University of Liverpool research warns. Published in the journal mBio, the findings highlight the need to develop new drugs and treatment regimens for the lethal brain infection, which kills around 180,000 people each year. Cryptococcal…
The U.S. Food and Drug Administration (FDA) announced the global launch of Cure ID, an internet-based repository that will allow the clinical community to report their experiences treating difficult-to-treat infectious diseases with novel uses of existing FDA-approved drugs through a website, a smartphone or other mobile device. The platform enables the crowdsourcing of medical information from…
Research led by scientists from McMaster University has yielded a potent antimicrobial that works against the toughest infectious disease strains. The find could be the beginning of developing new therapeutics to combat drug-resistant infections. The discovery is important as it is directly related to the development of Staphylococcus aureus diseases, known popularly as staph infections, which…
T2 Biosystems, Inc., a leader in the development and commercialization of medical diagnostic products, and CARB-X, a global non-profit partnership dedicated to accelerating R&D innovation to address the rising global threat of drug-resistant bacteria, announced the granting of a CE mark to the T2Resistance Panel. With the CE mark, T2 Biosystems has met the requirements of the In-Vitro…
Antibiotic-resistant pathogens pose one of the greatest threats to public health worldwide. In the near future, harmless bacterial infections may no longer be treatable and may again become the most common non-natural cause of death. At the same time, the available repertoire of antibacterial agents is becoming increasingly smaller as resistance rates rise.
PHE’s latest English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) report shows that there were an estimated 61,000 antibiotic resistant infections in England during 2018, a 9 percent rise from 2017.[i]
Teams of researchers from Charité – Universitätsmedizin Berlin and the Medical University of Innsbruck have developed a new therapeutic concept for the treatment of temporal lobe epilepsy. It represents a gene therapy capable of suppressing seizures at their site of origin on demand. Having been shown to be effective in an animal model, the new method will now be optimized for clinical use.…
Scientists from Scotland are developing a low cost, rapid diagnostic sensor test which aims to show the susceptibility of bacteria to antibiotics within 45 minutes. Laboratory testing of samples can take up to two days and the new test aims to allow doctors to be able to prescribe the correct antibiotic to a patient for an infection more quickly. In a research paper published in the journal…
A team of researchers lead by Helmholtz Zentrum München and the University of Würzburg identified an enzyme as a novel and strong inhibitor of ferroptosis, the iron dependent form of cell death: ferroptosis suppressor protein-1, short FSP1. This protein is expressed in a variety of cancer cell lines and therefore represents an attractive drug target for cancer treatment. In fact, the first FSP1…
Scientists have uncovered a novel antibiotic-free approach that could help prevent and treat one of the most widespread bacterial pathogens, using nanocapsules made of natural ingredients. Helicobacter pylori is a bacterial pathogen carried by 4.4 billion people worldwide, with the highest prevalence in Africa, Latin America and the Caribbean. Although the majority of infections show no symptoms,…
A study by a team of Victoria University of Wellington scientists spotlights the role of gene networks in how people respond to one of the world’s most prescribed medications. The research team investigated the genetic network response to cholesterol-lowering drugs called statins, a medication prescribed to about 30 million people worldwide. The researchers say it is a significant step towards…
For decades now, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing processes and systems for cleaning, sterilization, and surface modification. The newly in-house developed process, called SULEEI, makes it possible to sterilize (S) and preserve decellularized pericardial tissue by means of photo-initiated ultraviolet (U) crosslinking…
T2 Biosystems and CARB-X announced that the T2Resistance Panel is the first diagnostic to graduate from CARB-X’s portfolio.
A person with drug resistant epilepsy who gets an early surgical intervention has a better chance of becoming seizure free. This is shown in a systematic review and meta-analysis in which Sahlgrenska Academy researchers, in collaboration with the Swedish Council for Assessment of Health Technology and Social Services (SBU), analysed results from a range of previous studies. They concluded that…
Researchers identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau hereditary cancer. In a recent publication in PNAS, the research group identified how to kill therapy-resistant cells in hypoxic tumors and in cells arising in the von Hippel-Lindau (VHL) hereditary cancer.
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research from the University of Bath has shown. In addition cigarette smoke exposure can make some strains of Staphylococcus aureus – a microbe present in 30-60% of the global population and responsible for many diseases, some fatal – more invasive and persistent, although the effect is not universal across all…
Researchers at the University of Birmingham have shown that it’s possible to produce a compound with anti-cancer properties directly from feverfew – a common flowering garden plant. The team was able to extract the compound from the flowers and modify it so it could be used to kill chronic lymphocytic leukaemia (CLL) cells in the laboratory. Feverfew is grown in many UK gardens, and also…
New research has found that antibiotic-resistant strains of Klebsiella pneumoniae, an opportunistic pathogen that can cause respiratory and bloodstream infections, are spreading through hospitals in Europe. Certain strains are resistant to the carbapenem antibiotics that represent the last line of defence in treating infections and are therefore regarded as extremely drug resistant (XDR).
Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast. But often what ails us is inside the body and is not so easy to reach. In such cases, a treatment like surgery or chemotherapy might be called for. A pair of researchers in Caltech's Division of Engineering and…
Global warming may have played a pivotal role in the emergence of Candida auris. According to a new study published in mBio, an open-access journal of the American Society for Microbiology, C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change.
The World Health Organisation's (WHO) Essential Medicines List and List of Essential Diagnostics are core guidance documents that help countries prioritize critical health products that should be widely available and affordable throughout health systems. Now, updated versions of the two lists have been published, focusing on cancer and other global health challenges, with an emphasis on effective…
Many countries across the world are challenged with a rising number of incidences of multi-drug resistant (MDR) organisms infecting the population, and for several years, a clear pattern of increased resistance has emerged in southern and eastern European countries. For example, in countries such as Italy, a reduced number of therapeutic options remain available for highly pathogenic infections,…
Cancers with the same genetic weaknesses respond differently to targeted drugs depending on the tumour type of the patient, new research reveals. The study is set to prompt changes in thinking around precision medicine—because it shows that the genetics of a patient's cancer may not always be enough to tell whether it will respond to a treatment. The researchers are already starting to design…
As leaders gather for the International Ministerial Conference on antimicrobial resistance (AMR), hosted by the government of The Netherlands and organised in close cooperation with the FAO, OIE and WHO, experts and responsible manufacturers are calling for a 'One Health' approach to AMR and recognition of the impact of antibiotic production on the environment. "With two thirds of the worlds…
Immuno-oncology is a therapy in which the body’s immune system treats a tumour. Dr Eric Borges, from the Research and Development Centre at Boehringer Ingelheim Pharma GmbH in Germany, explains why this is revolutionary. Unlike conventional cancer therapies, with immuno-oncology the tumour cell is not the direct target, it’s the patient’s immune system. The medication stimulates this to…
Wilmot Cancer Institute scientists believe they have figured out why a commonly used drug to treat late-stage prostate cancer often stops working after four or five months and appears to have a dual function that later turns the cancer into a relentless aggressor.
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many…
Imperial medical students have helped to devise a new type of ‘decoy’ drug to tackle infections that are resistant to antibiotics. In lab tests on bacterial cultures, the new drug successfully killed a strain of drug-resistant bacteria. It works by delivering two antibiotics, one of which is effectively hidden. When the bacteria fight against the first ‘decoy’ antibiotic, this action…
High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumors consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment. Over half of the patients…
Scientists could help match cancer patients with no other treatment options to clinical trials with experimental medicines, by analysing the genetic faults in a sample of their blood. The researchers, funded by Cancer Research UK, The Christie Charity, AstraZeneca and the NIHR Manchester Biomedical Research Centre (BRC), demonstrated in their feasibility study that a blood test can be carried out…
Antimicrobial resistance is a global issue, with 700,000 deaths per year and 10 million expected deaths by 2050, according to predictions. Appropriate antimicrobial therapy can help to save lives, and a long awaited cure for carbapenemase-producing enterobacteriaceae (CPE) will soon be released, according to eminent Spanish expert Jose Mensa Pueyo, speaking at a Madrid meeting in March. The past…
Early detection and confirmation of carbapenemase-producing enterobacteriaceae (CPE) are essential when choosing the appropriate antimicrobial therapy and to implement infection control measures. Here, a leading Spanish microbiologist reviews an arsenal of tools currently available to clinicians. Resistance to beta-lactam antibiotics in enterobacteriaceae (EBc) is due to one or more of these…
Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of chordomas in advanced stages after conducting gene analysis. Their findings, published in the journal Nature…
For some cancers, initial treatment with chemotherapy brings positive, but only temporary, results: tumors shrink, but then rebound as the cancer becomes drug-resistant. This pattern of remission-resistance-relapse is particularly true for pancreatic cancer, an aggressive disease in which early success is often countered by eventual disease progression. To wit: The one-year relative survival rate…
Why do cancer cells react differently to treatments? Researchers from Mount Sinai and IBM have discovered a novel clue in explaining how cancer cells with identical genomes can respond differently to the same therapy. In a Nature Communications paper, researchers reveal for the first time that the number of mitochondria in a cell is, in great part, associated with how the cancer responds to drug…
It has long been thought that stress contributes to cancer progression. Scientists from the University of Basel and the University Hospital of Basel have deciphered the molecular mechanisms linking breast cancer metastasis with increased stress hormones.
A minimally invasive procedure to determine whether patients with drug-resistant epilepsy are candidates for brain surgery is safer, more efficient, and leads to better outcomes than the traditional method, according to new research by The University of Texas Health Science Center at Houston (UTHealth).
Grocery store aisles are stocked with products that promise to kill bacteria. People snap up those items to protect themselves from the germs that make them sick. However, new research from Washington University in St. Louis finds that a chemical that is supposed to kill bacteria is actually making them stronger and more capable of surviving antibiotic treatment. The study, available online in…
Researchers at the University of Strathclyde have developed an innovative, low cost test for earlier diagnosis of sepsis which could save thousands of lives. The simple system for sensitive real-time measurement of the life threatening condition is much quicker than existing hospital tests, which can take up to 72 hours to process. Using a microelectrode, a biosensor device is used to detect if…
Researchers have created a new machine learning software that can forecast the survival rates and response to treatments of patients with ovarian cancer. The artificial intelligence software, created by researchers at Imperial College London and the University of Melbourne, has been able to predict the prognosis of patients with ovarian cancer more accurately than current methods. It can also…
A team of scientists led by researchers at the University of Georgia Center for Food Safety in Griffin has developed a machine-learning approach that could lead to quicker identification of the animal source of certain Salmonella outbreaks. In the research, published in Emerging Infectious Diseases, Xiangyu Deng and his colleagues used more than a thousand genomes to predict the animal sources,…
Researchers at the University of Waterloo have developed a new way to prevent and treat Chlamydia, the most common sexually transmitted bacterial infection in the world. The new treatment differs from the traditional antibiotic treatment as it is a type of gene therapy that is delivered via nanotechnology and is showing a 65 per cent success rate in preventing chlamydia infection on a single…
When Olivia Nelson was 3 years old, her parents noticed that she had a fever that wouldn’t get better. They brought her to a nearby hospital, where she spent about two weeks being screened for diseases. As doctors tried to find a diagnosis, a lymph node on Olivia’s neck became swollen. Alarmed and wanting an answer, the Nelsons asked to transfer to Seattle Children’s. “It was very…
As European health services are pressured to provide the best possible care for best possible value, some medical fields are now very much the poor relation; this is particularly true for mental health. Mental illnesses represent a great health burden and cause huge financial and societal pressure in terms of direct and indirect costs from repeated hospitalisation and treatment failures, while…
More than 100 million Americans have potentially deadly fatty liver disease and most do not even know it. Overeating and drinking excessive amounts of alcohol this holiday season could put someone with the disease on the fast track to liver failure. “There are no symptoms associated with fatty liver disease and no pain, so most people never get checked or treated for it and, over time, if it is…
Antibiotic stewardship is becoming a critical concern in hospitals as antibiotic resistance spreads globally and some organisms become resistant to antibiotics of last resort. Molecular diagnostics can play a role in antibiotic stewardship programs by providing timely and accurate advice to clinicians on which antibiotics to use, Professor Keith Stanley advises. "Antibiotic resistance in the…
Hip and dental implant operations are routine. But not entirely risk-free. They may result in infection that is difficult to control with oral or intravenous antibiotics. In such cases, the implant will probably need to be replaced. Fraunhofer researchers can now apply a precisely matched drug directly to the replacement implant while significantly increasing the effectiveness of the antibiotic…
Researchers have developed laser-activated nanomaterials that integrate with wounded tissues to form seals that are superior to sutures for containing body fluids and preventing bacterial infection. Tissue repair following injury or during surgery is conventionally performed with sutures and staples, which can cause tissue damage and complications, including infection. Glues and adhesives have…
The baroreceptor reflex is a fascinating medical phenomenon. The reflex is controlled by specialized neurons that react in just a fraction of a second to keep blood pressure fairly consistent. For example, when you stand up, your blood pressure normally drops—rapidly. Yet you don't faint thanks to baroreceptors, which tell your heart rate to increase and push more blood to your brain. A new…
The most common form of Mycobacterium tuberculosis (TB) originated in Europe and spread to Asia, Africa and the Americas with European explorers and colonialists, reveals a new study led by UCL and the Norwegian Institute of Public Health.
Sepsis remains a common and deadly condition that occurs when the body reacts to an infection in the bloodstream. Scientists know little about the early stages of the condition; however, physicians must act fast. Every hour that passes without one or more of the few treatments available increases the risk of death.
A research team led by Arun Iyer, Ph.D., assistant professor of pharmaceutical sciences in the Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University, has developed a nanoplatform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma.
An international collaboration between Imperial College London, Singapore's Duke-NUS Medical School and Belgium-based pharmaceutical company UCB led to the discovery of a new anti-epileptic drug target and a whole new approach that promises to speed up the discovery of future drugs to treat debilitating diseases, such as epilepsy.
Scientists at the Virginia Tech Carilion Research Institute (VTCRI) have found evidence that may disrupt conventional understanding about how electrical activity travels in the heart — a discovery that potentially can lead to new insight into medical problems such as heart arrhythmia and sudden cardiac death.
A multidisciplinary team of researchers from the National University of Singapore (NUS) has developed an artificial intelligence (AI) technology platform that could potentially change the way drug combinations are being designed, hence enabling doctors to determine the most effective drug combination for a patient quickly. Applying the platform towards drug resistant multiple myeloma, a type of…
Austrian researchers have accomplished an astounding feat: They created organoids that mimic the onset of brain cancer. This method not only sheds light on the complex biology of human brain tumors but could also pave the way for new medical applications.
The need to do more to combat resistance in Germany was keenly emphasised by delegates at the VDGH (The German Diagnostics Industry Association) event held in Berlin this May. Only the answer, or at least the common will, is missing to bring this threat under control via a concerted concept.
For the first time, a team of international researchers have mapped the family trees of cancer cells in acute myeloid leukaemia (AML) to understand how this blood cancer responds to a new drug, enasidenib. The work also explains what happens when a patient stops responding to the treatment, providing important clues about how to combine enasidenib with other anti-cancer drugs to produce…
Imagine a pathogen that infects completely healthy people and can cause blindness in one day and flesh-eating infections, brain abscesses and death in just a few days. Now imagine that this pathogen is also resistant to all antibiotics.
Liquid biopsies can increasingly help diagnose and monitor breast cancer, and tracking circulating tumour cells (CTC) in metastatic patients could prove effective in these applications and treatment planning. Efforts are currently underway to demonstrate CTC clinical use and much can be learned from completed studies in prostate cancer, speaker Michail Ignatiadis MD PhD highlighted in a dedicated…
Medicines given to household pets to kill fleas and ticks might be effective for preventing outbreaks of malaria, Zika fever and other dangerous insect-borne diseases that infect millions of people worldwide, according to a new study led by scientists at Calibr, a non-profit drug discovery institute closely affiliated with Scripps Research and TropIQ Health Sciences, a Dutch social enterprise.
New methods of studying the evolution of treatment resistance in head and neck cancer are being developed by researchers at the Johns Hopkins Kimmel Cancer Center. The scientists wanted to examine how cancers acquire resistance to treatment over time and whether those changes could be modeled computationally to determine patient-specific timelines of resistance.
Two blood tests can predict which subset of men with advanced prostate cancer will likely not benefit from anti-androgen therapies, providing doctors and patient added clarity on treatment options, according to a study led by Duke Cancer Institute.
More than a million neonatal deaths worldwide each year are estimated to be due to sepsis. In the UK there are approximately 90,000 admissions to neonatal intensive care units per year. Nearly all these patients receive antibiotic therapy during their hospital stay, but babies with a specific genetic change can suffer irreversible hearing loss as a result. Now, in a collaboration between…
Antimicrobial resistance is on the rise worldwide. This is becoming a problem for infectious diseases like tuberculosis as there are only a few active substances available to combat such diseases. Pharmacists at Martin Luther University Halle-Wittenberg (MLU) have now found a way to increase the efficacy of a common tuberculosis agent while, at the same time, reducing resistance to it. The…
Gram-negative pathogens are responsible for half of all healthcare-associated infections and their ability to resist traditional antibiotics makes them more dangerous for seriously ill patients in a healthcare setting. The need for new approaches to treat these pathogens is essential and there are a number of trials trying to find suitable answers. One of them is the RESTORE-IMI 1 pivotal Phase…
Pediatric researchers have found that children and adults treated with some oral antibiotics have a significantly higher risk of developing kidney stones. This is the first time that these medicines have been linked to this condition. The strongest risks appeared at younger ages and among patients most recently exposed to antibiotics. “The overall prevalence of kidney stones has risen by 70…
Partners who could hardly be further apart – yet have a lot in common – have united to fight resistant pathogens. The International Consortium for Anti-Infective Research (iCAIR) is based in Germany and Australia – separated by nearly 16,000 km as the crow flies. This has not stopped the research cooperation from achieving its objectives: the development of new agents against infections.
Beta-lactam antibiotics, including penicillin, are one of the most widely used classes of antibiotics in the world. Though they’ve been in use since the 1940s, scientists still don’t fully understand what happens when this class of drugs encounters bacteria. Now, researchers at the University of Notre Dame have elucidated how an enzyme helps bacteria rebound from damage inflicted by…
Researchers from the University of Illinois at Chicago and Nosopharm, a biotechnology company based in Lyon, France, are part of an international team reporting on the discovery of a new class of antibiotics. The antibiotic, first identified by Nosopharm, is unique and promising on two fronts: its unconventional source and its distinct way of killing bacteria, both of which suggest the compound…
Feline AIDS is caused by the Feline Immunodeficiency Virus (FIV), which is very similar to the HIV-1 virus that affects millions of humans. While FIV does not infect humans, many groups research the virus to benefit cats, and perhaps more importantly, because of its many parallels with the AIDS virus. Despite the use of dedicated drugs, HIV-1 manages to thrive and multiply within the cell and…
In standard settings, the analysis of each DNA modification requires a carefully optimised assay that runs under specific conditions. This increases cost and labour and is a severe limitation to throughput. Now, however, researchers at Stanford University and the Technical University of Denmark have come up with a new method that will enable doctors to make a more precise diagnosis, prognosis and…
A major summit meeting in London, Great Britain, has seen politicians, doctors, scientists, farmers and other experts come together in a bid to tackle the growing global antimicrobial resistance (AMR) crisis. Among these experts was Dame Sally Davies, England’s Chief Medical Officer, who described AMR as a ‘problem without a face’ because most patients are not told they have a resistant…
Cell-based biosensors can simulate the effect of various substances, such as drugs, on the human body in the laboratory. Depending on the measuring principle, though, producing them can be expensive. As a result, they are often not used. Cost factors for sensors that perform measurements electrically are the expensive electrode material and complex production. Fraunhofer scientists are now…
Testing cancer drugs on miniature replicas of a patient’s tumour could help doctors tell in advance which treatments will work, a major new study reports. The exciting new technique involves growing ‘mini tumours’ from biopsy samples – and could help end reliance on trial and error in selecting cancer treatments for patients where genetic tests are not predictive of response. Researchers…
Nurses have a distinctive and crucial role in the development and implementation of sound health policy,’ according to Annette Kennedy, President of the International Council of Nurses, which represents 135 National Nurses Associations and around 17 million nurses worldwide.
WHO’s first release of surveillance data on antibiotic resistance reveals high levels of resistance to a number of serious bacterial infections in both high- and low-income countries. WHO’s new Global Antimicrobial Surveillance System (GLASS) reveals widespread occurrence of antibiotic resistance among 500 000 people with suspected bacterial infections across 22 countries.
Tumor imaging technique has potential as anti-cancer weapon, mouse study shows.
Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team from Perelman School of Medicine at the University of Pennsylvania says it may have…
Bacteria not only develop resistance to antibiotics, they also can pick it up from their rivals. In a recent publication, Researchers from the Biozentrum of the University of Basel have demonstrated that some bacteria inject a toxic cocktail into their competitors causing cell lysis and death. Then, by integrating the released genetic material, which may also carry drug resistance genes, the…
Viral infections kill millions of people worldwide every year, but currently available antiviral drugs are limited in that they mostly act against one or a small handful of related viruses. A few broad-spectrum drugs that prevent viral entry into healthy cells exist, but they usually need to be taken continuously to prevent infection, and resistance through viral mutation is a serious risk. Now,…
The U.S. Food and Drug Administration is announcing a new approach to get critical updates regarding antibiotics and antifungal drugs to health care professionals as part of an overall effort to combat antimicrobial resistance. The agency created a website that will provide direct and timely access to information about when bacterial or fungal infections are likely to respond to a specific drug.…
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect…
Findings published in Oncotarget offer new hope for children with highly aggressive brain tumors like atypical teratoid/rhabdoid tumor (AT/RT) and medulloblastoma. Previously, the authors of the study have shown that an experimental drug that inhibits polo-like kinase 4 (PLK4) stopped pediatric brain tumor growth in vitro. Now, they have demonstrated its success in an animal model – the drug…
Testing for fever, high pulse rate, crackly breath sounds, and low oxygen levels could be key to helping GPs distinguish pneumonia from less serious infections, according to a large study published in the European Respiratory Journal. Pneumonia is a severe lung infection that can be life-threatening and often requires treatment with antibiotics. However, it is notoriously difficult to…
An SLAS Technology review article by Yiyan Li, Xing Yang and Weian Zhao of University of California, Irvine highlights and synthesizes representative emerging micro- and nanotechnologies, as well as automated systems for bacterial identification (ID) and antibiotic susceptibility testing (AST), including both phenotypic and molecular methods and those at the point-of-care (POC) setting. Also…
Artificial intelligence (AI) has taken centre stage during the Medica Academy sessions. While talks focus on initiatives made in Germany, European Hospital took a look at Spain and spoke with Ignacio Hernández Medrano, a neurologist recently elected as one of the most influential people in healthcare (HC). At just 34 years old, Medrano has already founded two flagship AI projects, one of which…
During our European Hospital interview with specialist in microbiology, virology and infection epidemiology Beniam Ghebremedhin MD, from the University Hospital Wuppertal, spoke about the impact of migration on infections, and ways to tackle the problem of multiresistant pathogens. ‘There is a lack of specialists in infectious diseases, for direct patient care on hospital wards as well as in…
Multidrug-resistant organisms (MDRO) are keeping infection specialists worldwide on their toes. One of these specialists travelled all the way from Leipzig to India to gain insights in one of the sources of the problem.
A new magnetic resonance imaging (MRI) contrast agent being tested by researchers at Case Western Reserve University not only pinpoints breast cancers at early stages but differentiates between aggressive and slow-growing types.
For years, medical investigators have tried and failed to develop vaccines for a type of staph bacteria associated with the deadly superbug MRSA. But a new study by Cedars-Sinai investigators shows how staph cells evade the body’s immune system, offering a clearer picture of how a successful vaccine would work.
Combining a new compound with old drugs could provide an effective remedy against malaria and drug-resistant parasites.
As cancer grows, it evolves. Individual cells become more aggressive and break away to flow through the body and spread to distant areas. What if there were a way to find those early aggressors? How are they different from the rest of the cells? And more importantly: Is there a way to stop them before they spread?
Recent outbreaks of Zika virus have revealed that the virus causes brain defects in unborn children. But researchers from Washington University School of Medicine in St. Louis and the University of California, San Diego report that the virus could eventually be used to target and kill cancer cells in the brain.
Antimicrobial resistance mortality is set to surpass cancer and traffic-related deaths by 2050, according to the UK National Health Service (NHS).
German researches have linked the increased production of a certain enzyme in the liver to fatty liver and insulin resistance.
Chronic lung infections caused by the bacterium Pseudomonas aeruginosa require complex and, in most cases, long-term treatment with antibiotics—new medication is badly needed.
The association of biofilms with multi-drug resistance has highlighted the need for further understanding of biofilms and for anti-biofilm strategies.
Cancer researchers in the UK may have stumbled across a solution to reverse antibiotic drug resistance and stop infections like MRSA. Experts warn we are decades behind in the race against superbugs having already exploited naturally occurring antibiotics, with the creation of new ones requiring time, money and ingenuity. But a team of scientists at the University of Salford say they may have…
Ares Genetics GmbH, a wholly-owned subsidiary of Curetis GmbH and a developer of pioneering solutions for the detection of genetic resistances in pathogens, announced that the project "GEAR - Predicting Antibiotic Resistances with Genetic Data" has been awarded in the competition "Landmarks in the Land of Ideas".
While new agents to fight virulent pathogens are in the pipeline, a new study pinpoints where a recent addition is already being applied in the clinic.
Trips around the globe, healthcare tourism, migration; we are mobile – and so are bacteria. Particularly dreaded are multi-drug resistant bacteria that ‘hop’ on their host during a hospital stay and are carried across the border. At MEDICA 2017 Labmed Forum Dr Andreas Ambrosch, Head of the Central Lab at Krankenhaus Barmherzige Brüder in Regensburg, Germany, will discuss these unwelcome…
Comprehensive examinations of 143 refugee patients hailing mostly from Afghanistan and Syria, which were conducted between June and December 2015, showed a high prevalence of MRSA, ESBL and MDRGN upon hospital admission. The figures exceed not only those of the general population but, alarmingly, also those found in high-risk groups, such as residents of nursing homes or home care service…
Today’s dilemma for hospitals and institutions are increasingly multi-resistant bacteria and decreasingly effective antibiotics to beat them. New substances to fight pathogens are not on the horizon. What can be done? Professor Constanze Wendt, microbiology and infection biology specialist at MVZ Labor Dr. Limbach & Kollegen GbR, in Heidelberg, Germany, describes current anti-infection…
In our interview with the physician Dr. Fabian Berger, we want to know about the advantages of molecular biological procedures compared to conventional C. difficile diagnostics.
SpeeDx Pty, Ltd. announced an agreement with Cepheid for distribution of its PlexPCRTM and ResistancePlusTM molecular diagnostic products in key markets throughout Europe. The agreement, covering Germany, France, Italy, and the UK, will increase coverage for the market-leading ResistancePlus MG test, the first CE-IVD test for Mycoplasma genitalium to combine detection with testing for…
Many diabetes patients must inject themselves with insulin, sometimes several times a day, while others take medications orally to control blood sugar. The injections, as well as the side effects from both regimens, can be painful. Now, one team reports in the Journal of the American Chemical Society progress toward an insulin-free diabetes treatment that requires fewer injections.
Researchers in Japan have identified a receptor protein on the surface of heart cells that promotes chronic heart failure. The study, “Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction” suggests that inhibiting this protein could help treat a disease that affects more than 20 million people worldwide.
Finding a cure for a rare type of blood cancer could be accelerated by a new virtual platform that allows researchers easy access to data from patient samples generated by laboratories around the world. LEUKomics, which has been launched by scientists at the University of Glasgow and the University of Melbourne, is a comprehensive database describing over 100 chronic myeloid leukaemia (CML)…
SpeeDx Pty. Ltd., a developer of innovative molecular diagnostic solutions, has signed an agreement with Thermo Fisher Scientific, the world leader in serving science. The announcement was made at the 27th European Congress of Clinical Microbiology and Infectious Disease (ECCMID) in Vienna to submit its ResistancePlus MG Test for the detection of Mycoplasma genitalium to the US Food & Drug…
Foods should be investigated as a potential source of spread of Clostridium difficile, according to research presented at the 27th ECCMID [1].
Following a top level EU report showing antimicrobial resistance (AMR) remains high, Professor Mike Catchpole, Chief Scientist at the European Centre for Disease Prevention and Control (ECDC), has warned that stricter use of antibiotics is critical.
Curetis, a developer of next-level molecular diagnostic solutions, today announced that the Company has established Ares Genetics GmbH, a wholly owned subsidiary of Curetis GmbH. Ares Genetics builds on GEAR GEnetic Antibiotic Resistance and Susceptibility Database and associated assets recently acquired for Siemens. The Company will use GEAR to investigate the genetic foundations of antibiotic…
Nemus Bioscience and the University of Mississippi report significant anti-MRSA synergy data utilizing proprietary cannabinoid-based anti-infective platforms.
Novel blood or urine tests can now detect a tumour and but might in future be able to say what type of cancer is developing in which organ.
European Hospital reports a new approach in molecular diagnostics introduced during the IASLC World Conference in Vienna.
Adding UV light to standard cleaning cut transmission of 4 resistant bacteria by 30 percent
Experts at a university in the United Kingdom have designed a large-scale data and mapping project that they hope will help in the global fight against infectious diseases.
Experts at the European Committee on Antimicrobial Susceptibility Testing (EUCAST), who define the optimal drug concentrations to inhibit the growth of pathogens, have found that genetic methods cannot yet be used to test for susceptibility in a number of important bacterial species.
Menarini-Silicon Biosystems announced the company’s DEPArray single-cell isolation technology played a key role in a study conducted by researchers from The University of Manchester to develop a model for predicting whether small-cell lung cancer patients will be sensitive or resistant to initial chemotherapy treatment.
On European Antibiotic Awareness Day (EAAD), the European Public Health Alliance and the European Patients Forum jointly call on the European Commission and national governments to step up the fight against drug-resistant infections in the follow-up EU Action Plan on Antimicrobial Resistance announced for 2017. The EU has a vital role to play in protecting health security in Europe and empowering…
What do Casey Kasem, Christopher Reeve and Muhammad Ali have in common? They all died of sepsis: a rapid, potentially deadly reaction that affects millions each year.
Virology is fast emerging as a key discipline within modern healthcare against a backdrop of a shifting global demographic and the impact of climate change.
Airports are international travel hubs visited by large numbers of people. London Heathrow, for example, has an average of 205,400 travellers every day and saw 75 million people arriving and departing from all over the world in 2015. A study just published in the journal Clinical Microbiology and Infection suggest that international travellers can acquire antimicrobial-resistant bacteria and may…
An international study, led by the University of Southampton, shows the UK and France experience the highest number of malaria cases imported from other countries.
A global spotlight has at last highlighted the truly acute problem of antimicrobial resistance.
The increasing numbers of bacteria resistant to the newer generations of antibiotics is a public health problem on a global scale. Bacteria have an extraordinary capacity for adaptation, mutating permanently to overcome the action of our increasingly impotent antimicrobial armamentarium. A situation further aggravated by the use of the powerful ‘large spectrum’ antibiotics, creating further…
A team of researchers at Yale found that a treatment using bioadhesive nanoparticles loaded with a potent chemotherapy drug proved more effective and less toxic than conventional treatments for gynecological cancer.
Malaria remains one of the world’s leading causes of mortality in developing countries. Last year alone, it killed more than 400,000 people, mostly young children. An international consortium of researchers unveiled the mechanics and findings of a unique “open science” project for malaria drug discovery that has been five years in the making.
Multidrug resistance (MDR) is the mechanism by which many cancers develop resistance to chemotherapy drugs, resulting in minimal cell death and the expansion of drug-resistant tumors. To address the problem of resistance, researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) have developed nanoparticles that…
Curetis announced the signing of an asset acquisition agreement with the Siemens Technology Accelerator GmbH (STA). Under the terms of the agreement, Curetis has acquired sole commercial rights from STA to the GEAR GEnetic Antibiotic Resistance and Susceptibility platform and database with all its content, numerous GEAR-related patents and patent applications, as well as all corresponding…
Many breast tumors grow in response to female hormones, especially estrogen. Drugs that reduce estrogen levels in the body often are effective in reducing tumor size and preventing recurrence of the cancer. But some tumors become resistant to these therapies and continue to grow and spread.
Australian researchers have made a world-first breakthrough in the early detection of patients' resistance to a common treatment for chronic myeloid leukemia. The discovery offers some hope that the patients' treatment could be changed sooner to improve their chances of survival.
The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the American Society for Microbiology (ASM) are jointly organizing a conference in Vienna from 21 – 23 September 2016 to help researchers accelerate the development of new antimicrobials for drug-resistant infections.
Thousands upon thousands of humans have taken and are continuing to take flight from wars, persecution and economic stress, seeking the chance of survival in European and other countries. They arrive not only physically exhausted, but also in mourning for those killed in their own countries, or during hellish journeys – therefore many also suffer unimaginable mental traumas. Clearly they need…
Scientists from the University of Zurich have been able to understand for the first time why many cancer cells adapt relatively quickly to the treatment with therapeutic antibodies in invasive forms of breast cancer. Instead of dying off, they are merely rendered inactive. The researchers have now developed an active substance that kills the cancer cells very effectively without harming healthy…
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
The mechanism by which drug-resistant bacteria maintain a defensive barrier has been identified by researchers at England’s University of East Anglia (UEA) and their findings could result in a new wave of drugs that can bring down those defensive walls rather than attack the bacteria – thus they may not develop drug-resistance at all.
As one of medicine’s largest challenges, viral infections often escape vaccines due to their natural ability to mutate rapidly and develop drug resistance easily. Many viruses, such as Zika, Ebola and dengue fever, have grown into major global health epidemics with great human and economic toll. IBM Research and Singapore’s Institute of Bioengineering, Nanotechnology (IBN) announced they have…
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
As a leading global provider of both diagnostic imaging and analytical instrumentation technologies, Shimadzu offers broad expertise in medical imaging and mass spectrometry detection platforms helping to deliver a measurable impact on healthcare and diagnosis. The company is the perfect partner for transformational technologies to accelerate diagnosis.
As scientists scramble to get a Zika virus vaccine into human trials by the end of the summer, a team of researchers is working on the first-ever vaccine to prevent another insect-borne disease – Leishmaniasis – from gaining a similar foothold in the Americas.
On top of the meaning and mystery that humans heap on the heart, it is first and foremost, a muscle. And one that beats about once a second for a person’s entire life, with no rest. Given its vital importance, it’s ironic researchers have only recently made direct observations of its subcellular parts in motion.
At a recent focus meeting held in Berlin by the Association of Accredited Laboratories in Medicine, Dr Andreas Weimann, managing director at the Laboratory Berlin – Charité Vivantes Services, spoke of the challenges that laboratories working with hospitals face due to the management of pathogens and the diagnosis of infections.
A simple blood test can rapidly and accurately detect mutations in two key genes in non-small cell lung tumors, researchers at Dana-Farber Cancer Institute and other institutions report in a new study – demonstrating the test’s potential as a clinical tool for identifying patients who can benefit from drugs targeting those mutations.
Small cell lung cancer is not usually detected until it is at an advanced stage, when metastases have already formed. Chemotherapy is very effective initially but, within a year, cancer recurs and this time does not respond to a course of chemotherapy. The research group headed by Gerhard Hamilton, University Department of Surgery at MedUni Vienna, has now managed to identify the reason for this…
A novel class of compounds developed by a University of Saskatchewan (U of S)-led research team could yield more effective and less toxic chemotherapy drugs to treat cancer. Team leader Jonathan Dimmock, a medicinal chemistry researcher in the U of S College of Pharmacy and Nutrition, explained their compounds work by interacting with thiols, naturally occurring chemicals that perform several…
A team of researchers at the MedUni Vienna has, in collaboration with the AIT Austrian Institute of Technology, developed two new PET tracers that allow the activity of drug transporters at the blood-brain barrier to be measured. The studywas able to demonstrate that people with a genetic polymorphism in a transporter gene have lower transporter activity at the blood-brain barrier, which can lead…
Although tuberculosis (TB) is commonly thought of as being a disease that mainly affects nineteenth century poets and Victor Hugo characters, it is still the second-most common cause of mortality from an infectious disease in the world, killing nearly three people every minute.
A team of investigators from Houston Methodist Research Institute may have transformed the treatment of metastatic triple negative breast cancer by creating the first drug to successfully eliminate lung metastases in mice.
Scientists at the German Cancer Research Center (DKFZ) and the Stem Cell Institute HI-STEM in Heidelberg have discovered the reason why some pancreatic tumors are so resistant to treatment. They have found that these tumor cells produce larger quantities of an enzyme that usually occurs in the liver and degrades many drugs. If this enzyme is blocked, the cancer cells become sensitive towards…
Tumours kill off surrounding cells to make room to grow, according to new research from the University of Cambridge. Although the study was carried out using fruit flies, its findings suggest that drugs to prevent, rather than encourage, cell death might be effective at fighting cancer – contrary to how many of the current chemotherapy drugs work.
There’s apparently safety in numbers, even for cancer cells. New research in mice suggests that cancer cells rarely form metastatic tumors on their own, preferring to travel in groups since collaboration seems to increase their collective chances of survival, according to researchers at Johns Hopkins.
Researchers have identified a mechanism that allows cancer cells to respond and grow rapidly when levels of sugar in the blood rise. This may help to explain why people who develop conditions in which they have chronically high sugar levels in their blood, such as obesity, also have an increased risk of developing certain types of cancer.
Mom’s eyes and dad’s tumor? Cancer is due to genetic defects, some of which can be hereditary. The gene variant rs351855, for example, occurs in one in two cancer patients. A team headed by Axel Ullrich from the Max Planck Institute of Biochemistry in Martinsried identified the gene variant a decade ago. Now, they succeeded for the first time in showing that the variation exposes an otherwise…
A new injectable “biogel” is effective in delivering anti-cancer agents directly into cancerous tumours and killing them. This technology, developed by researchers at the University of Montreal Hospital Research Centre (CRCHUM), has already been successfully tested in the laboratory. If it works in patients, the therapy could one day revolutionize treatment for many forms of cancer.
A new report gives the first ever picture of global investment in Ebola research and development (R&D), reporting that this investment might have come at the expense of efforts to develop drugs, vaccines and diagnostics for other neglected diseases, which collectively cause more than six million deaths every year in developing countries.
Astellas Pharma EMEA today announced that it will host the Antimicrobial Resistance in Europe: Innovating Today to Protect our Health Tomorrow debate at the Bibliothèque Solvay, Brussels, on 3rd December, 2015. The event will convene leading scientists and economists from across Europe to discuss how policy-level innovation can address antimicrobial resistance (AMR) – the single greatest…
Scientists at the University of Strathclyde in Glasgow have been working to identify compounds with important anti-infective activity and suitable for treating serious infectious diseases caused by bacteria and parasites, such as Clostridium difficile. Their work has led to the creation of the new drug known as MGB-BP-3 (MGB = minor groove binder). Report: Mark Nicholls
As the World Health Organization (WHO) ramps up its fight against antibiotic resistance, a new multi-country survey shows people are confused about this major threat to public health and do not understand how to prevent it from growing.
A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests. And the process used to create the virus-fighting form may help scientists develop even more drugs, by harnessing the “sugar code” that our cells use to communicate. That code gets hijacked by…
Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences have found that the breast cancer drug tamoxifen gives white blood cells a boost, better enabling them to respond to, ensnare and kill bacteria in laboratory experiments. Tamoxifen treatment in mice also enhances clearance of the antibiotic-resistant bacterial pathogen…
In a hospital, what you can’t see could hurt you. Healthcare facilities continue to battle drug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA) that loiter on surfaces even after patient rooms have been cleaned and can cause new, sometimes-deadly infections.
Researchers compared an immunotherapy and a chemotherapy drug in patients with non-squamous non-small cell lung cancer (NSCLC) whose disease continued to progress after first-line chemotherapy. They found that nivolumab improved overall survival and was generally well tolerated. The results are significant because options for patients whose lung cancer progresses after initial treatment are…
Half a million square feet. More than 350 beds. And tomorrow, they clean it all over again. Every day, Environmental Services (EVS) staff members work to disinfect every surface in Children’s Hospital Los Angeles, playing a crucial behind-the-scenes role in preventing infections and keeping patients safe. Now, on top of scrubbing, spraying, mopping and wiping, they can add another action –…
EKF Diagnostics, the global in vitro diagnostics company, announces that two research posters supporting the application of its PointMan DNA enrichment technology, for rapid and sensitive detection of lung cancer mutations, have been delivered at key conferences.
It is estimated that half of all cancer patients suffer from a muscle wasting syndrome called cachexia. Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients. Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the McGill University Health Centre (RI-MUHC) and University…
For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it’s a cellular pathway that’s found in everything from yeast to mammals. mTOR (as it’s called in mammals) plays a central role in instructing the cell to grow and divide in response to nutrients. When it’s turned down, the cell shifts into a second, tidying mode,…
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms, which contribute to antimicrobial resistance.
At Europe’s largest meeting for clinical laboratories, Beckman Coulter stepped forward to welcome a new class of customers looking for familiar and reliable instruments. Report: John Brosky
Vaccination remains one of the most efficient strategies against infectious diseases, often being the best protection against infections such as hepatitis B, or influenza. European Hospital reports on expert reviews of vaccines in the pipeline and the potential of nanomedicine given during the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) annual meeting in…
The World Health Organization (WHO) estimated that in 2013, malaria infected 198 million people and killed 584,000, the majority of whom were African children. The compound that detectives spray at crime scenes to find trace amounts of blood may be used one day to kill the malaria parasite.
A blood clot is a dangerous health situation with the potential to trigger heart attacks, strokes and other medical emergencies. To treat a blood clot, doctors need to find its exact location. But current clinical techniques can only look at one part of the body at a time, slowing treatment and increasing the risk for complications. Now, researchers are reporting a method, tested in rats, that…
Researchers at Rice University and University of Texas MD Anderson Cancer Center have developed a way to mimic the conditions under which cancer tumors grow in bones.
ESCMID Fungal Infection Study Group (EFISG) argues that fungal resistance now represents a huge healthcare threat – with many cases remaining massively undiagnosed even in the developed world – and that there is a rising prevalence of the most invasive and deadly forms. Conversely, in the developing world we are seeing very treatable fungal infections killing huge numbers – half a million…
A new drug acts as a roadblock for malaria, curing mice of established infection, according to a study in The Journal of Experimental Medicine. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans.
Within 15 years effective antibiotics will run out and, far from being an apocalyptic fantasy, a world in which common infections and minor injuries can kill is a very real possibility for the 21st Century. Geoff Sussman, one of the world’s foremost wound experts has warned that antibiotic resistance is posing the biggest single threat to global health. Report: Mark Nicholls
Lung cancer is the leading cause of cancer death worldwide, responsible for some 1.59 million deaths a year. That figure is due, in part, to the fact that the cancer often returns after what, at first, seems to be successful treatment. And the recurring cancer is often resistant to the chemotherapy and other drugs that originally drove it into remission. According to new research by the Weizmann…
Weizmann Institute scientists identify a potential drug molecule that stops cancer cells, but not healthy ones, from getting their “mail”.
Urinary tract infections (UTIs) are common, and widespread antibiotic resistance has led to urgent calls for new ways to combat them. Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences report that an experimental drug that stabilizes a protein called HIF-1alpha protects human bladder cells and mice against a major UTI…
This article discusses examples of applications of genetic analyses in coagulation disorders and haematological and oncological diseases. Professor Christine Mannhalter highlights the impact changes have on the occurrence and severity of diseases and their influence on therapy response. Report: Christine Mannhalter
About 6-8% of Spanish patients will develop an infection during or after a hospital stay. Can these infections be avoided? How is Spain facing up to the challenge? Dr Juan Pablo Horcajada, Head of the Department of Infectious Diseases at Hospital del Mar, Barcelona, and spokesperson of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), assessed the situation and…
A new way of rapidly identifying bacteria, which requires a slight modification to a simple microscope, may change the way doctors approach treatment for patients who develop potentially deadly infections and may also help the food industry screen against contamination with harmful pathogens, according to researchers at the Korea Advanced Institute of Science and Technology (KAIST) in Daejeon,…
The time needed to genetically sequence the bacteria causing tuberculosis (Mtb) from patient samples has been reduced from weeks to days using a new technique developed by a team at University College London (UCL). This could help health service providers to better treat disease, control transmission of this infection, and monitor outbreaks.
The USA’s President Barack Obama released a comprehensive plan in March to slow the emergence of drug-resistant bacteria, a multi-year, billion-dollar effort that includes getting doctors to stop over-prescribing antibiotics, developing new medications and rapid diagnostics, and real-time tracking of infection outbreaks. Report: Lisa Chamoff
Expecting 10,000 participants, prior to the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Copenhagen, Denmark (25-28 April) its Programme Director, Professor Winfried V Kern MD, was keen to point out: ‘The findings and recommendations that emerge from this vibrant platform each year have, in the past, had a tremendous impact not only on guidelines and best…
Prescribing antibiotics for a viral infection with fever, a cold and a cough? There is no point! This is the best-known example of over-use in medicine. There are also numerous examples of diagnostic procedures and therapies that are pointless, yet still being doled out in surgeries and hospitals – sometimes even harming a patient. This is set to change, according to the German Society of…
A group of leading scientists has warned that Britain and Europe collectively could face more than a million deaths in an impending "Antibiotic Armageddon” unless more is spent on developing new cures, rapid diagnostics and preventative measures to combat the spread of drug resistant diseases.
30 years after HIV was discovered to be the cause of the acquired immune deficiency syndrome AIDS, and despite intensive research, no vaccine or cure has yet been found. An international team of scientists, in collaboration with the German Center for Infection Research (DZIF) and the University Hospital of Cologne, has now tested a new generation of antibodies in humans for the first time. They…
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) announces that the globe’s most prominent infection specialists will be gathering in Copenhagen to explore solutions to the biggest infection problems during its annual congress – the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) taking place on 25-28 April 2015.
A new "lab-on-a-disc" technology developed by an EU project research team can diagnose malaria and other febrile infectious diseases simultaneously in just an hour - allowing faster point-of-care treatment and precise drugs administration that could save thousands of lives.
Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well-known "resistance" mutations in the gene called epidermal growth factor receptor (EGFR).
The European Society for Clinical Microbiology and Infectious Diseases (ESCMID) has been joined by the World Health Organisation (WHO) to launch the 7th annual ‘International Day for Fighting Infection’ (April 24th, 2015). This year’s event sees the European society exploring vaccines as a possible solution in the global, cross-border fight against antimicrobial resistance.
The ‘MRI of the Adnexa, Essentials and Beyond’ session from at the MR 2015 symposium held in Garmisch, Austria, presented tips and tricks in clinical routine before moving to research that combines imaging and genomic data to better evaluate ovarian cancer. Report: John Brosky
Researchers at the Hubrecht Institute and the University Medical Center (UMC) Utrecht successfully developed a culturing system for human liver stem cells as well as stem cells from pancreatic cancer. They describe the development of these culturing systems in two articles in this week’s edition of Cell magazine.
Taking antibiotics for diarrhea may put travelers visiting developing parts of the world at higher risk for contracting superbugs and spreading these daunting drug-resistant bacteria to their home countries, according to a new study published in Clinical Infectious Diseases and now available online.
Women with metastatic breast cancer know they have a slim chance of long-term survival. The question is whether personalised therapy could extend their lives. Report: Cynthia E Keen
Scientists have discovered a new antibiotic, teixobactin, that can kill serious infections in mice without encountering any detectable resistance, offering a potential new way to get ahead of dangerous evolving superbugs.
Prosthetic joint infections (PJI) are the most frequent complication in orthopaedic implant patients and may occur any time: weeks, months, or even years after an implantation. Report: Ludger Weß
A new extracorporeal nanotech device addresses the root cause of sepsis by removing pathogens and endotoxins simultaneously from blood even before their identification – this genetically engineered mannose-binding lectin protein can also latch on to the Ebola virus... Report: Cynthia E Keen
Among updates on breast cancer diagnostics and treatments aired at the 33rd German Society for Senology meeting last year was SpheroTest, an evidence-based tool that helps select the most effective drug for each individual cancer patient. Report: Anja Behringer
Is chlorhexidine still the best decolonisation method? For many decades decolonisation – be it selective intestinal, oral or skin decolonisation – has been the accepted procedure to prevent infections by endogenous bacteria. Report: Brigitte Dinkloh
Approach could improve treatment of drug-resistant infections. Combining a PET scanner with a new chemical tracer that selectively tags specific types of bacteria, Johns Hopkins researchers - working with mice report - have devised a way to detect and monitor in real time infections with a class of dangerous Gram-negative bacteria.
Personalised medicine is often equated with the development of drugs tailored to the genetic make-up of patients or cancers.
An ‘Achilles heel’ in the defensive barrier surrounding drug-resistant bacterial cells has been identified by a team of scientists at the University of East Anglia (UEA) in Norwich, UK.
France, like all European countries, is concerned about the increasing spread of multi-antibiotic resistant bacteria but.
In May, the World Health Organisation (WHO) warned that bacterial infections might lead to an increasing number of deaths because new resistance mechanisms threaten our ability to treat common infectious diseases.
New molecular technologies to screen drug-resistant TB are replacing, for example, culture-based tests that are slow, require experienced personnel, and need stringent microbiological safety precautions.
Researchers from the University of Heidelberg and the German Cancer Research Center (DKFZ) have developed a new method that uses light to control processes in living cells.
While the Generating Antibiotic Incentives Now (GAIN) Act of 2012 has been a significant step in the right direction for encouraging novel antibiotics research, the US Food and Drug Administration (FDA) remains one step behind its European equivalent, the European Medicines Agency (EMA), according to an analyst with research and consulting firm GlobalData.
A Birmingham hospital trust is to lead a major research study over concerns that one of the commonest sexually transmitted infections is becoming resistant to current treatment.
Finnish pharma company Orion and German healthcare giant Bayer have entered into an agreement for the development and commercialisation of a novel drug targeting prostate cancer.
Using pictures and symbols, rather than handwritten words, on prescriptions helps illiterate patients take their medicines correctly when they leave hospital, say doctors today. The idea was first tested in a hospital in Pakistan using simple pictures of the sun, moon and stars to help patients understand when and how long to take their medication for.
It was the quiet before the storm. At the end of March, during the American College of Cardiology (ACC) meeting in Washington, the future of renal denervation was about to be decided with the presentation of the Medtronic-funded Simplicity HTN-3 clinical trial.
imec, the European research centre for nanoelectronics, has linked with Johns Hopkins University in Baltimore, USA, to develop the next generation of highly miniaturised medical tools.
It is the quiet before the storm. At the end of March, the future of renal denevation will be decided with the presentation of the Simplicity HTN-3 clinical trial at the American College of Cardiology meeting in Washington.
Approximately 1.7 billion people worldwide carry Mycobacterium tuberculosis (MTB), i.e. about one-third of the population. The rate of new infections is highest in Africa, followed by certain Asian regions, including areas in Russia.
Two things that radiologists resist – structured reporting and (computer-assisted) quantification – are the very things that Gabriel Krestin believes are essential to advance diagnosis in the brave new world of omic-medicine that is emerging.
The number of patients treated with implants – from cardiac pacemakers, heart valves and vascular implants to artificial hips and knees – is rising worldwide.
Virtual observation of patients taking prescribed TB medication could prove an effective technique to ensure they effectively complete their treatment course, according to research presented at the European Respiratory Society (ERS) Annual Congress held in Barcelona.
Internet-based training for clinicians could help lower antibiotic prescribing rates for acute respiratory tract infections by as much as 62%, according to British researchers.
At Bracco Suisse SA in Geneva all efforts are dedicated to contrast media for ultrasound scans. During their visit to the firm’s research centre and manufacturing site, Daniela Zimmermann and Ralf Mateblowski met with François Tranquart MD PhD, general manager of the Bracco Suisse research centre, to hear why SonoVue is now Europe’s most popular ultrasound contrast agent, with research…
The C-Pulse, manufactured by Australian-American company Sunshine Heart, Inc. is neither a pulsatile artificial heart nor one of the well-known non-pulsatile left heart support systems
A new procedure may help people with persistent hypertension. By burning or ablating the nerves in the renal arteries, blood pressure levels can be reduced significantly.
Like any other cancer – breast cancer is a highly individual disease, shaped by many factors such as age, health status or genetics. Due to the complex web of molecular pathological processes and resistance mechanisms it is very difficult to select the most effective therapy for each patient.
Sanofi and the Curie Institute, through its Curie-Cancer partnership under the Institut Carnot label, today announce the establishment of a three-year research collaboration to identify new therapeutic targets for the development of treatments for ovarian cancer.
Over 32% of HIV+ people in Europe remain undiagnosed. This large untapped pool and the development of novel nucleic acid test (NAT) and non-NAT technology based platforms offers growth potential for HIV diagnostics manufacturers.
A recent webinar, hosted by the American Association of Clinical Chemistry, featured doctors Duane Newton of the University of Michigan and Susan Novak-Weekly of Kaiser Permanente.
A dynamic new consortium was launched in October during the recent Innovation in Oncology event organised by the German Cancer Research Centre (DKFZ) with Heidelberg University Hospital.
The use of in-line filters for infusion therapy significantly lowers the rate of severe complications in children aged between 0-18 years being treated in intensive care units, according to a new study from the Paediatrics Clinic at Hannover Medical School (MHH). The study also confirmed that the number of cases of systemic inflammatory response syndrome, SIRS, dropped substantially through the…
As in so many European countries, nosocomial infections have hit the headlines in Germany over and over again in recent years – as when three premature babies died in a Bremen neonatal clinic in 2011.
There is no other way: We need a comprehensive approach, with everyone living up to their responsibility to combat this serious health threat in their respective areas. The most basic instinct of every living organism is survival. What selects one organism or species over another, in fact, is its capacity to withstand any kind of adverse condition that comes its way – what scientist Herbert…
Personalised cancer medicine is much discussed, with high expectations for biomolecular decoding of various tumours and the global pharma industry developing targeted drugs to attack tumours at a biomolecular level.
Dr Peter Choyke, Chief of the Molecular Imaging Programme at the National Cancer Institute in Bethesda, USA, believes that new tracers will have an evolving role to play and represent an exciting development in the imaging of cancers.
Modern wars will be fought in the cyber zone, targeting an enemy's communications technology to cause critical damage; a Tel Aviv University researcher suggests to employ similar tactics in the battle against cancer.
With few experts, we need to raise awareness among physicians and undertake research to upgrade our knowledge of this disease
For some, ‘life’s a bitch’ with unfairness and suffering an integral part of it. Many more people actually do not expect any better than the barrenness and misery in which they live, EH Malta Correspondent Moira Mizzi reflects.
Johns Hopkins experts in the prevention and treatment of multidrug-resistant tuberculosis are calling for increased screening and more rapid testing of the 9 million people worldwide estimated to be infected each year with TB, and now at risk for this form of the highly contagious lung disease.
Johns Hopkins experts in the prevention and treatment of multidrug-resistant tuberculosis are calling for increased screening and more rapid testing of the 9 million people worldwide estimated to be infected each year with TB, and now at risk for this form of the highly contagious lung disease.
Johns Hopkins scientists have published laboratory data refuting studies that suggest blood vessels that form within brain cancers are largely made up of cancer cells. The theory of cancer-based blood vessels calls into question the use and value of anticancer drugs that target these blood vessels, including bevacizumab (Avastin).
Using a mathematical formula that carefully measures the degree to which HIV infection of immune system cells is stalled by antiretroviral therapy, AIDS experts at Johns Hopkins have calculated precisely how well dozens of such anti-HIV drugs work, alone or in any of 857 likely combinations, in suppressing the virus.
‘Before each ward round my students and I wash our hands’ – so said Ignaz Philip Semmelweis in the mid-19th century, in his drive to reduce the hospital mortality rate. Today, the World Health Organisation states that ‘Clean care is safer care’ – and yet, particularly in recent times, the lack of hygiene in numerous hospitals has resulted in mortalities. Who is to blame? What can be…
Research into new methods to prevent and slow metastatic breast cancer will be presented this week at the Era of Hope conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program (BCRP).
In Europe, nosocomial infections cause about 25,000 deaths every year. Copper has strong antibiotic effects and may reduce hospital acquired infections.
Professor Bill Keevil, Director of the Environmental Healthcare Unit at University of Southampton’s School of Biological Sciences, was among the first microbiological researchers to experiment on copper’s efficiency against pathogenic and nonpathogenic strains of E. coli bacteria and demonstrate the inherent anti-microbial property of the metal.
Although powerful, new, targeted treatments are regularly introduced to cancer clinics, choices for the first-line treatment of invasive breast cancer normally lie between preventive surgery and chemotherapy. A recent American study used genomic prediction combining multiple signatures to determine outcomes to standard chemotherapy.
Cold plasma jets could be a safe, effective alternative to antibiotics to treat multi-drug resistant infections, says a study published this week in the January issue of the Journal of Medical Microbiology. The team of Russian and German researchers showed that a ten-minute treatment with low-temperature plasma was not only able to kill drug-resistant bacteria causing wound infections in rats but…
Improvements in microfluidics and detection technologies are beginning to expand the range of point-of-care diagnostics beyond simple blood chemistry tests to sophisticated immuno-assays and molecular diagnostics. Though yet to see much adoption in European hospitals, these point-of-care (POC) diagnostics are coming into use in the USA, initially in emergency rooms and ICUs where fast results are…
Every year in German hospitals about 15,000 patients acquire ventilation-associated pneumonias (VAP). This number, and the associated mortality, is striking enough to make it one of the topics at HAI 2010, the annual conference of the German Society for Anaesthesiology and Intensive Care Medicine (DGAI). Like many physicians, Dr Maria Deja, senior physician at the Charité Clinic for…
Cancer stem cells (CSCs) are the engine that drives tumour growth. They can not only reproduce themselves but also differentiate to form all the specialised cells found within a tumour. While chemotherapy and radiotherapy non-specifically target all rapidly dividing cells, there is increasing evidence that CSCs are more resistant to these treatments. Report: Karoline Laarmann
During his Honorary Lecture at the 8th Düsseldorf Breast Cancer Conference in Germany world renowned surgeon and oncologist Prof. Veronesi reflected about the prevention and treatment of breast cancer.
Italian surgeon and oncologist Prof. Dr. Umberto Veronesi, Founder and Scientific Director of the European Institute of Oncology in Milan and former National Health Minister (2000 – 2001), is considered to be one of the biggest authorities on breast cancer research of our time. Many breakthrough changings in cancer medicine sustainably go back on his researches, which once earned him also a…
The daily management of diabetes mellitus is a complex interaction between blood glucose measuring, lifestyle aspects and drug therapy. Large epidemiological trials such as UKPDS (United Kingdom Diabetes Prospective Study) have shown that an optimal blood glucose adjustment has beneficial long-term effects on type-2 diabetics’ risk of micro- and macrovascular secondary complications.
The border between Germany and the Netherlands in the so-called EUREGIO region is of no particular importance in the daily life of the people who live there. Every day, thousands commute between towns and cities in both countries, to work, shop or even receive medical treatment. The latter, however, presents Dutch hospitals with a problem.
The Opening Lecture at ECR always draws immense attention. On March 4th, it was the “First Lady of Radiology” as Congress President M. Szczerbo-Trojanowska called her, Professor Dr Anne G. Osborn, University of Utah, USA, who opened the event. The internationally renowned doctor of diagnostic neuroradiology spoke about “The two faces of HIV/AIDS in the brain” – a matter close to her…
In type 2 diabetes, which is occurring at alarming rates, the hormone insulin does not work effectively to lower blood sugars and patients also do not make enough insulin. These two processes have been widely considered as separate. However, a surprising discovery was made by Joslin Diabetes Center researchers in animal models of diabetes: insulin is important in regulating its own production.…
One of the main topics at Health Forum Gastein 2009 was the way in which various healthcare systems struggle to cope with communicable diseases and their prevention. During the event, Dr Hans Kluge, Head of the Country Policies and Systems Unit, at the WHO regional office for Europe, spoke with Meike Lerner about omnipresent factors that work against effective TB and HIV/AIDS prevention…
It is very difficult to predict whether a cancer drug will help an individual patient: only around one third of drugs will work directly in a given patient. Researchers at the Heinz Nixdorf Chair for Medical Electronics at the Technische Universitaet Muenchen (TUM) have developed a new test process for cancer drugs. With the help of microchips, they can establish in the laboratory whether a…
The threat of communicable diseases will become even worse in the near future. At the European Health Forum Gastein, the European Union's leading health policy congress for experts and decision-makers, experts stressed that there are a number of risk factors which contribute to a growing risk of the spread of communicable diseases into Europe, namely into the European Union.
Positive CB7630 (Abiraterone Acetate) Phase II Data was presented at the ASCO Annual Meeting in Chicago this May/June, Cougar Biotechnology Inc, a development stage biopharmaceutical firm with a specific focus on oncology. In mid-July, Johnson & Johnson announced its acquisition of Cougar, which is now working with Ortho Biotech Oncology Research & Development, a division of the J&J firm Centocor…
Full automation has now become the gold standard for clinical laboratories. Without hospital microbiology labs, which according to the Centres for Disease Control deal with 1.7 million infections and 99,000 associated deaths annually in the US alone, the growing threat of community-acquired and nosocomial infections could prove insuperable.
The Research Institute of the Hospital Universitari Vall d'Hebron (IR-HUVH) in Barcelona is the first Spanish health centre to acquire the Genome Sequencer FLX System from 454 Life Sciences, a Roche company. This new high-performance sequencing system improves the productivity and precision of genome sequencing at IR-HUVH.
HIV/AIDS has reached pandemic proportions. 35 million people are infected. Given the situation of hard pressed general practitioners (GPs) today, as well as geographical and other difficulties (as in Africa, for example), a new device that will enable HIV patients to monitor their own health and the effectiveness of treatments, without visiting their doctors so often, is indeed promising.
The first strain of methicillin resistant Staphylococcus Aureus (MRSA) was isolated in the 1960s, and its presence was reported worldwide in the late 1990s. A higher incidence of MRSA was noted in communities, at the dawn of the new millennium, leading to two basic MRSA strains being differentiated - CA-MRSA (community acquired MRSA) and HA-MRSA (healthcare associated MRSA). In clinical practice…
According to ECD statistics for Europe, three million cases of nosocomial infections occur annually, and 50,000 are fatal. Evelina Tacconelli MD PhD (below) is Assistant Professor of Infectious Diseases at the Università Cattolica Sacro Cuore in Rome, Italy. Her scientific focus is on epidemiology, clinical and therapeutic aspects of nosocomial infections and infection control policies aimed to…
Dr Giorgio Rizzatto, who heads the Department of Diagnostic Imaging at ASS 2 Isontina (including the Gorizia and Monfalcone hospitals) in NE Italy, works with nine radiologists, who examine and report on 80,000 clinical and screening breast examinations annually.
Biomarkers are biochemical features or facets that can be used to measure the progress of disease or the effects of treatment.
Czech hospitals are seeking powerful inspiration regarding antibiotics (ATB) consumption from France, where a recent public campaign helped to decrease ATB consumption by 30%.
The machine 'qViro' which is the size of a coffee grinder will make virus counting much cheaper than traditional virus counting technology. The revolutionary new invention offers the potential to quickly muster and count the number of viruses in a sample in minutes - it is a portable, desktop instrument, powered from the USB drive of a computer - current competitors are the size of washing…
The next flu season will come. To prevent high-risk people from infections, the National Institute for Health and Clinical Excellence (NICE) recently published a final guidance on the use of the drugs oseltamivir, amantadine and zanamivir for the prophylaxis of influenza. "But vaccination is the main way to prevent flu", says Gillian Leng, NICE Deputy Chief Executive.
GenoType® MTBDR plus, a new molecular test for multidrug-resistant tuberculosis has recently been approved in Europe. The test, developed by the Foundation for Innovative New Diagnostics (FIND) and Hain Lifescience, offers a fast solution to detect MDR-TB and XDR-TB at a reasonable price, a good condition for the application in poorer countries.
ESC speaker John Cleland from the University of Hull, UK, sumed up the latest treatment available for patients with diabetes mellitus and expressed his worries about side-effects and efficacy of available anti-diabetic drugs. If you want to read his ESC abstract, just click the “read more” button.
As an increasing number of international drug companies are moving their clinical trials business to India, the clinical trial industry has been raising concerns about the lack of regulation of private trials carried out there, including the uneven application of requirements for informed consent and proper ethics review.
It was a mistery: Why didn't drugs which boost the tumor-killing power of immune cells in lab do well in clincal trials? Now researchers from Rockefeller University describe a way to enhance the ability of these drugs by combining them with radiation therapy.
A new paper by Shahriar Mobashery, Navari Family Professor in Life Sciences at the University of Notre Dame, and researchers in his lab provides important insights into promising new antibiotics aimed at combating MRSA.
An international panel of physicians has updated the guidelines and recommendations for antiretroviral treatment of adult human immunodeficiency virus (HIV) infection after evaluating recent data, according to an article in JAMA, a theme issue on HIV/AIDS.
So called circulating tumor cells (CTC) seem to be an indicator of the progression and therapy outcome for cancer patients. US- and UK-researchers have shown concurrently that blood tests of CTC's are as reliable as painful biobsies to predict how well patients respond to therapy.
The HER2 gene causes a very aggressive kind of breast cancer. It influences the number of cancer stem cells and therefore as well the spreading of metastases. The University of Michigan Comprehensive Cancer Center now made the discovery that the drug Herceptin can drastically reduce the amount of the stem cell population in HER2 positive-breast cancer.
Pharma company Eli Lilly has increased an existing partnership with the World Medical Association (WMA) by granting c. 646,505 euros to expand online training courses for physicians on multi-drug resistant tuberculosis (MDR-TB), which they have been developed over the past year.
As nosocomial, or healthcare-related infections (HAIs), continue to escalate in the US, and protocols to manage this problem remain complex and confusing, surveillance healthcare IT systems offer hope to gain control of the situation. These offer the potential for data to be uniformly collected, quantified, and assessed. How rapidly they will be implemented enough is unknown.
Every three minutes, two people living in India die of tuberculosis. This equates to approximately 370,000 deaths each year, and a staggering economic toll: an estimated US$300 million in direct costs and US$3 billion in indirect costs.
By putting the World TB Day slogan 'I am stopping TB' into action, 11 nurses have earned the 2008 ICN/Lilly Award, for their outstanding work in fighting tuberculosis (TB) and multi-drug resistant TB (MDR-TB)[1]. The award recipients come from six TB affected countries: from Kenya (Diana Jelegat Kipsoisoi), Lesotho (Likhapha Ntlamelle ), Malawi (Chrisie Bwazi, Rodwell Gundo and Shouts Simeza),…
The WHO-Euro region ranges from Portugal to the East Asian parts of Russia, including Central Asia and the Southern Caucasus. Because of the increasing numbers of tuberculosis and rates of multidrug resistance (MDR TB), tuberculosis was declared a regional emergency in 2004.
Biotechnologist Dr Jens Meiler explains his reasons for emigration to America
According to a study that was recently published on bmj.com, researchers found evidence that a significant number of patients treated with low doses of aspirin for its antiplatelet effect are actually aspirin resistant. Such a resistance makes patients four times more likely to suffer a life-threatening stroke or heart attack.
Italy - The latest advance in stereotactic radiosurgery - the Leksell Gamma Knife Perfexion made by Elekta, is due for inauguration this month at the Neurosurgery Department in Niguarda Hospital, located in the northern area of Milan. This prestigious hospital employs over 700 physicians and 1,500 nurses, and over 50,000 patients are admitted annually, and over 20,000 surgical procedures are…
Every developing tissue is supplied by blood vessels with oxygen and nutrients. Tumours grow far more quickly than normal tissues, so have a greater need of nutrients, which is why tumour cells begin to produce growth factors that stimulate the formation of blood vessels.
By Professor Giovanni Battista Migliori MD, Director of the WHO Collaborating Centre for Control of Tuberculosis and Lung Diseases.
Today little is known about the metabolism of the tuberculosis bacillus and, because of its slow growth, experiments for new drugs take a long time. Now a team of researchers form the University of Surrey built an in silico model of the agent that causes TB - a virtual TB bacillus - that promises to speed up the drug discovery process.
In areas of the UK where tuberculosis has a high prevalence, screenings could increase diagnosis both of active and latent forms of the disease and therefore could help prevent its spread.
This was the motto of the ECR 2007 in Vienna, where a group of high-ranking experts discussed diseases of the 21st century; research competition between the US and Europe; the conditions needed to progress leading medical R&D - moderated by Congress President Professor Christian J Herold.
Researchers demonstrated the effectiveness and safety of a new drug for treating bloodstream and heart infections caused by Staphylococcus aureus bacteria.
As the German Society of Neuroradiology 40th annual meeting approached (Venue: Dresden. 31 August - 3 September), Professors Martin Schumacher (Freiburg), President of the German Society of Neuroradiology (GSN) and Rüdiger von Kummer (Dresden), the meeting's President, examine the history and potential in this medical field
The latest textile technologies go along with fabric integrated sensors, or computers, to measure e.g. the functioning of a patient's cardiovascular system.
The decoding of the genome has made it possible for molecular biology specialists to detect predispositions for illnesses and treat them accordingly.
25,000 visitors and medical professionals from 47 National Cardiac Societies across central and greater Europe, will attend the 2004 ESC Congress, where 'Diabetes and heart disease' will be the main theme. Lars Ryden, ESC Past-President, team member for the Euro-Heart Survey on Diabetes, and Chairman of the 'Guidelines for Diabetes & the Heart', and William Wijns, co-chair and Chairman of the…
TB causes three million deaths annually, ranking it higher than any other infectious disease. And TB has resurged in Europe. In August, the British Thoracic Society, British Lung Foundation and TB Alert highlighted its increase in over the last 15 years in the UK alone.
Prostate cancer, the most common neoplasm in men, often progresses from an androgen-dependant state (and is commonly treated by androgen ablation therapies) to a hormone-refractory stage, therefore making hormone therapy ineffective. The response duration to androgen ablation therapy is finite and ultimately most prostate cancer will become hormone-insensitive.