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Sponsored • Periprosthetic protection

Bone cements containing antibiotics for infection prophylaxis – quo vadis?

Periprosthetic infections and revisions are on the rise in Germany and worldwide, with significant consequences for affected patients as well as for the healthcare systems. Precisely because the number of patients at higher risk of infection in arthroplasty continues to rise, attention is increasingly focused on how this dreaded complication can be avoided. There is a growing need for strategies to delay the timing of primary and revision joint replacement and adjust/optimize patient comorbidities before surgery where possible.1 In addition to proper systemic infection prophylaxis, the use of an antibiotic-containing bone cement for knee or hip prosthesis fixation and local drug placement has proven to be an effective preventive measure.2 

Focus on periprosthetic infections

Current analyses of endoprosthesis registers and other databases in Germany1 and the USA3, among others, confirm the trend towards an increase in infections in connection with arthroplasty operations. This relates to primary, secondary and revision operations. After aseptic loosening, prosthesis infections were the second most frequent reason for joint replacement surgery in Germany in 2005 (hip: 10%, knee: 13.9%).4 

Alongside the individual burden of disease, periprosthetic infections also have an epidemiological and health economic dimension. According to recent projections, periprosthetic infections in the knee and hip joints in the USA will incur an estimated annual hospital cost of USD 1.85 billion in 2030;5 in the UK, the cost per patient is expected to be GBP 42,000 within five years of primary hip replacement with revision compared to GBP 8,000 without revision.6

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More and more patients at risk of infection

The rise in periprosthetic infections is particularly due to a higher number of patients presenting with one or more health-related risks for infection. Risk factors include:7 

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Image source: National Institute of Allergy and Infectious Diseases (NIAID)

  • Older age: According to data from the Swedish Endoprosthesis Register, 15.1% of hip replacement surgery patients were 85 years old or older in 2005, rising to 25.0% by 2020.8
  • Comorbidities: Comorbid and multimorbid patients are increasingly receiving joint replacements. Accordingly, the proportion of otherwise healthy patients with hip replacement (ASA 1 according to the American Society of Anesthesiologists) recorded in the Norwegian arthroplasty register fell from more than 30% to around 15% between 2005 and 2020.  At the same time, the proportion of operated patients with asymptomatic or symptomatic concomitant diseases of varying severity increased from approx. 70% to approx. 85% (ASA 2-5).9Typical concomitant diseases associated with a higher risk of infection are:
    1. Obesity
    2. Diabetes mellitus
    3. Malnutrition
    4. Chronic inflammatory diseases
    5. Severe heart or kidney failure
    6. Smoking
    7. Anaemia
  • Surgery-related risk factors: e.g., revision surgery, knee replacement surgery, joint replacement after femoral neck fracture7,10,11

Another important factor associated with an increased risk of infection is the spread of multi-resistant germs in the operating theatre and on the ward, which can significantly limit the efficacy of perioperative antibiotic prophylaxis and the treatment of a prosthesis infection. This constitutes a major issue especially in Southern European countries.

Bone cements containing antibiotics for infection prophylaxis – quo vadis?

Image source: Adobe Stock/SciePro

Risk-adapted infection prophylaxis

Under these conditions, risk-adapted infection prophylaxis may be particularly significant. This includes pre- and perioperative measures to reduce germs in the operating theatre as well as strategies for local and systemic antibiotic prophylaxis.7 It is important that surgeons are aware of the elevated risk of infection in certain patient groups and actively engage in optimised, antibiotic-based infection management – including the prophylactic use of bone cements containing antibiotics.12 

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Where the risk of infection is high, adjustments to standard prophylaxis may be appropriate, such as prolonged or combined systemic antibiotic administration or the combination of a systemic and a local antibiotic. In the latter case, higher doses of bone cements loaded with two antibiotics may be also used to fix the prosthesis.13,14,15,16 Administering a dual dose of local antibiotics has the advantage of strong and lasting antimicrobial effectiveness without an increased risk of systemic side effects. A few clinical studies have already demonstrated that the use of such cements with dual antibiotic loading reduces the incidences of infections in risk patients.7,13 In addition, this measure is the easiest to implement from a logistical point of view, as it only affects the decision as to which antibiotic-containing cement to use during surgery. An increase in resistance due to the use of dual antibiotic-loaded bone cement, on the other hand, is even less likely and has not actually been observed in clinical practice.7

Heraeus Medical – pioneer in infection management

Excellent options are available for infection prophylaxis that can be used in a situation-specific manner within the context of primary joint replacement or revision surgery.7 Both surgeons and patients must be able to rely on the high quality of the material and products. 

Heraeus Medical has decades of expertise in the development and production of bone cements with added antibiotics for effective infection management. In addition, the company also offers first-class training and e-learning opportunities with the PALACADEMY® for Surgical Orthopaedics, Traumatology and Operating Theatre Staff. 


References

  1. Rupp M, Walter N, Lau E, Worlicek M, et al. Recent trends in revision knee arthroplasty in Germany. Sci Rep. 2021;11:15479. 
  2. Sebastian S, Liu Y, Christensen R, Raina DB, et al. Antibiotic containing bone cement in prevention of hip and knee prosthetic joint infections: A systematic review and meta-analysis. J Orthop Translat. 2020;23:53-60.
  3. Edmiston CE, Jr., Chitnis AS, Lerner J, Folly E, et al. Impact of patient comorbidities on surgical site infection within 90 days of primary and revision joint (hip and knee) replacement. Am J Infect Control. 2019;47:1225-32.
  4. Bleß HH, Kip M. Weißbuch Gelenkersatz. Versorgungssituation bei endoprothetischen Hüft- und Knieoperationen in Deutschland. Berlin: SpringerNature; 2017.
  5. Premkumar A, Kolin DA, Farley KX, Wilson JM, et al. Projected Economic Burden of Periprosthetic Joint Infection of the Hip and Knee in the United States. J Arthroplasty. 2021;36:1484-9 e3.
  6. Garfield K, Noble S, Lenguerrand E, Whitehouse MR, et al. What are the inpatient and day case costs following primary total hip replacement of patients treated for prosthetic joint infection: a matched cohort study using linked data from the National Joint Registry and Hospital Episode Statistics. BMC Med. 2020;18:335.
  7. Berberich C, Josse J, Sanz Ruiz PS. Patients at a high risk of PJI: Can we reduce the incidence of infection using dual antibiotic-loaded bone cement? Arthroplasty. 2022;4:41.
  8. Dahl AW, Kärrholm J, Rogmark C, Nauclér E, et al. The Swedish Arthroplasty Register. Annual Report 2012. 2021.
  9. Bergen HF. Norwegian National Advisory Unit on Arthroplasty and Hip Fractures. Annual Report 2021. 2021.
  10. Quinlan ND, Werner BC, Brown TE, Browne JA. Risk of Prosthetic Joint Infection Increases Following Early Aseptic Revision Surgery of Total Hip and Knee Arthroplasty. J Arthroplasty. 2020;35:3661-7.
  11. Pirisi L, Pennestri F, Vigano M, Banfi G. Prevalence and burden of orthopaedic implantable-device infections in Italy: a hospital-based national study. BMC Infect Dis. 2020;20:337.
  12. Rupp M, Walter N, Baertl S, Lang S, et al. Antibiotic Prophylaxis and Empirical Antibiotic Therapy in Primary Arthroplasty and Periprosthetic Joint Infections: Current Practice and Need for Therapy Optimization. Z Orthop Unfall. 2022.
  13. Berberich CE, Josse J, Laurent F, Ferry T. Dual antibiotic loaded bone cement in patients at high infection risks in arthroplasty: Rationale of use for prophylaxis and scientific evidence. World J Orthop. 2021;12:119-28.
  14. Claret G, Tornero E, Martinez-Pastor JC, Piazuelo M, et al. A Prolonged Post-Operative Antibiotic Regimen Reduced the Rate of Prosthetic Joint Infection after Aseptic Revision Knee Arthroplasty. Surg Infect (Larchmt). 2015;16:775-80.
  15. Inabathula A, Dilley JE, Ziemba-Davis M, Warth LC, et al. Extended Oral Antibiotic Prophylaxis in High-Risk Patients Substantially Reduces Primary Total Hip and Knee Arthroplasty 90-Day Infection Rate. J Bone Joint Surg Am. 2018;100:2103-9.
  16. Sewick A, Makani A, Wu C, O'Donnell J, et al. Does dual antibiotic prophylaxis better prevent surgical site infections in total joint arthroplasty? Clin Orthop Relat Res. 2012;470:2702-7.


Source: Heraeus

17.11.2022

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