Assoc Prof Alfredo Franco-Obregón (right), Dr Alex Tai (left) and their team...
Assoc Prof Alfredo Franco-Obregón (right), Dr Alex Tai (left) and their team have developed a new magnetic therapy to be used in combination with chemotherapy for treatment of breast cancer.

Image source: National University of Singapore

News • Companion treatment

Magnetic therapy to enhance breast cancer chemotherapy

Breast cancer is the leading cause of cancer-associated death for women worldwide. While chemotherapy is the mainstream treatment for breast cancer, more than 50% of women undergoing chemotherapy will experience at least one chemotherapy-related adverse side effect.

Sometimes, the side effects could be so severe that patients need to terminate treatment early or doctors have to reduce the chemo dosage, and this could worsen their disease. Prolonged exposure to high doses of chemotherapeutic agents could also result in resistance to chemotherapy. 

A team of researchers from the National University of Singapore (NUS) is pioneering a novel magnetic therapy – delivered using the OncoFTX System – that serves as an effective companion therapy to chemotherapy to enhance treatment outcome for breast cancer. “Our magnetic technology stimulates cellular oxygen respiration to produce energy. In certain cancers with elevated respiratory rates – such as breast tumours – the magnetic pulses cause the cancer cells to ‘hyperventilate’ and die. Fortunately, the healthy tissues near the cancer are able to tolerate the increased respiratory rate, without ill consequences. Therefore, the OncoFTX System is more selective for cancer than conventional chemotherapy or radiotherapy. Importantly, this therapy is localised, non-invasive and painless,” explained Associate Professor Alfredo Franco-Obregón who leads the team comprising researchers from the NUS Institute for Health Innovation & Technology as well as Department of Surgery under the NUS Yong Loo Lin School of Medicine. 

These research findings were published in the scientific journal Frontiers in Oncology.

Magnetic therapy to enhance breast cancer chemotherapy

Image source: National University of Singapore; Infographic by Zac Goh

Assoc Prof Franco-Obregón added, “The ultimate hope is that the combination is so effective that it reduces reliance on chemotherapy and its associated chemo side effects, as suggested by our published preclinical studies, but remains to be shown in human trials.” 

Each session of magnetic therapy involves exposing a breast tumour to a pulsed magnetic field at a strength of 3 milliTesla, for one hour. This field amplitude is about 50 times greater than the amplitude of the Earth’s magnetic field, but 1,000 times smaller than conventional magnetic resonance imaging. The imminent safety and efficacy trials will determine the best treatment frequency for breast cancer patients. 

The OncoFTX System uses a pulsed magnetic field to stimulate cancer cells to...
The OncoFTX System uses a pulsed magnetic field to stimulate cancer cells to ‘hyperventilate’ and die. This serves as an effective companion therapy to chemotherapy to enhance treatment outcome for breast cancer.

Image source: National University of Singapore 

In their recent study, the NUS team discovered that cancer cells that express high levels of TRPC1 – a cancer-causing gene associated with various types of cancers, such as breast cancer, pancreatic cancer, glioblastoma multiforme, lung cancer, hepatic cancer, multiple myeloma, and thyroid cancer – are more vulnerable to the magnetic therapy. Hence, elevated TRPC1 expression could be used to identify patients who are suitable for a combination treatment involving magnetic therapy and selected chemotherapeutic agents such as doxorubicin (adriamycin). 

The NUS team had also demonstrated through laboratory and preclinical studies that a combination of pulsed magnetic field exposure and chemotherapy drug doxorubicin was effective in reducing the size of breast cancer tumours. Assoc Prof Franco-Obregón commented, “Cancer cells are inherently unstable as they are in a constant state of metabolic catastrophe. Our breast cancer magnetic signal stimulates the TRPC1-mitochondria pathway, increasing the production of oxygen free radicals and resulting in ultimate demise of cancer cells.”

Our long-term goal is to establish its safety and efficacy in enhancing local treatment effect of chemotherapy to help patients achieve maximal shrinkage with minimal side effects

Joline Lim

To further validate their findings, the research team plans to embark on a first-in-human safety trial in the second half of 2022, in collaboration with the National University Cancer Institute, Singapore (NCIS) at the National University Hospital. The one-year clinical trial is expected to involve about 30 breast cancer patients who will undergo the magnetic therapy in combination with chemotherapy. 

Dr Joline Lim, Consultant, Department of Haematology-Oncology, NCIS, said, “We observed encouraging results from preclinical studies showing improvement in local shrinkage of breast tumour. This first-in-human study will help to determine the safety of this therapy in patients, both given alone and in combination with chemotherapy. Our long-term goal is to establish its safety and efficacy in enhancing local treatment effect of chemotherapy to help patients achieve maximal shrinkage with minimal side effects.” 

The NUS team also plans to test the effectiveness of their magnetic therapy in other types of solid tumours – such as prostate cancer – with and without chemotherapy. “Prostate cancer shares many similarities with breast cancer as both are primary epithelial in nature and are hormone-driven malignancies. We have also found that prostate cancer is associated with elevated TRPC1 expression. This makes prostate cancer a likely candidate for us to apply the magnetic therapy to ascertain its effectiveness,” said Assoc Prof Franco-Obregón. In the long term, the NUS team hopes their discovery will enable scientists to better optimise magnetic regimens for more effective killing of cancer cells, and in turn, translate this knowledge into effective therapies to benefit cancer patients. 


Source: National University of Singapore

04.05.2022

Read all latest stories

Related articles

Photo

News • Tumor location as important growth factor

New molecular microscopy uncovers breast cancer spread

Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease.

Photo

News • Possible biological explanation found

Why are dense breasts associated with increased cancer risk?

The risk of developing breast cancer is higher in breasts with high density. But why is that? Researchers at Linköping University have shown major biological differences that promote cancer growth.

Photo

News • Filopodia research

'Sticky fingers' in cells keep breast cancer contained

Researchers in Finland have identified that finger-like cellular extensions called filopodia contribute to building a barrier surrounding breast tumours.

Related products

AB-CT – Advanced Breast-CT – nu:view

Mammo CT

AB-CT – Advanced Breast-CT – nu:view

AB-CT – Advanced Breast-CT GmbH
Fujifilm – Amulet Bellus II

Mammo Workstations

Fujifilm – Amulet Bellus II

FUJIFILM Europe GmbH
Fujifilm – AMULET Innovality

Tomosynthesis

Fujifilm – AMULET Innovality

FUJIFILM Europe GmbH
Fujifilm – AMULET Innovality Harmony

Tomosynthesis

Fujifilm – AMULET Innovality Harmony

FUJIFILM Europe GmbH
IMS Giotto – Giotto Class Smartfinder

Digital Mammography

IMS Giotto – Giotto Class Smartfinder

IMS Giotto S.p.A. (GMM Group)
IMS Giotto – Giotto Flexitable

Biopsy Units

IMS Giotto – Giotto Flexitable

IMS Giotto S.p.A. (GMM Group)
Subscribe to Newsletter