Search for: "biomarkers" - 250 articles found

Article • Digital pathology and AI

Finding new biomarkers to match the biological complexity of cancer

Advances in artificial intelligence and multimodal data integration are poised to revolutionise cancer diagnostics – but significant challenges remain before these technologies can be routinely deployed in clinical practice. Professor Manuel Salto-Tellez outlined the steps needed to bridge the gap between complex tumour biology and the relatively simple biomarkers currently available, speaking…

News • Chronic neurological disorder

Researchers identify early signs of Parkinson's in the blood

Researchers report on decisive steps towards an early diagnosis of Parkinson’s disease: a newly discovered biomarker in the blood could open a window of opportunity for future treatment.

Article • From observation to action

The rise of agentic AI in pathology

Computational pathology is becoming increasingly important in helping deliver precision medicine to a wider range of patients. Experts at the 37th European Congress of Pathology in Vienna discussed how algorithms can optimise laboratory workflows, generate stronger evidence for molecular tumour boards, and enhance clinical trial design.

News • Residual lung abnormality

Promising biomarker detects lingering lung damage after Covid-19

A new study into the long-term health impacts of coronavirus has found changes in the blood after Covid-19 that might pinpoint patients at risk of ongoing lung disease.

News • Laboratory equipment

CE IVDR certification for new benchtop hematology analyzer

Analytical and measurement technology copany Horiba has obtained CE IVDR certification for its new Yumizen H500 CRP benchtop hematology analyzer, designed for small laboratories.

News • Quantification of axonal damage

Detecting white matter injury with diffusion MRI

Non-invasive, millimetre-scale diffusion MRI (dMRI) can be used to detect morphological changes in axons – a common hallmark of a wide range of neurological disorders, new research shows.

News • Focus on tumor STAT1 acetylation

How cancer cells learn under pressure to evade immunotherapy

Immunotherapy has been hailed as a breakthrough in cancer treatment. But new research reveals: under sustained treatment pressure, cancer does not simply weaken — it adapts, learns, and fights back.

News • Remote sampling

Home blood test for Alzheimer's shows promise

An international study shows that Alzheimer’s disease biomarkers can be accurately detected using simple finger-prick blood samples that can be collected at home and mailed to a laboratory.

News • Drivers of gray matter injury

Multiple sclerosis: Promising biomarker linked to progression and brain inflammation

A new University of Toronto-led study has discovered a possible biomarker linked to multiple sclerosis (MS) disease progression that could help identify patients most likely to benefit from new drugs.

News • Between the heart and the brain

Why cardiovascular disease and depression often develop together

Cardiovascular disease and depression do not co-occur by chance; the TO_AITION project aims to enable earlier diagnosis of comorbidity, better risk prediction and personalised treatment strategies.

News • Brain damage analysis

Blood biomarker predicts recovery after cardiac arrest

A simple blood test that can very accurately predict the chance of survival with good recovery could be of great significance for patients in intensive care after a cardiac arrest.

News • Adaptive re-planning

Repurposed radiotherapy scans to guide prostate cancer treatment

Radiotherapy is effective against prostate cancer but can cause side effects. Using AI, scientists found that images originally taken to help position patients could also predict rectal bleeding.

News • Identification of high-risk patients

Preventing kidney damage after surgery with biomarkers

Even minor functional impairments of the kidneys can have serious consequences for patients after major surgery. New biomarkers could help identify high-risk patients at an early stage.

News • Exploration of novel biomarkers

Depression: not just a disease of the mind

Depression is not only a disease of the mind or the brain, a new study finds: a research team has revealed deep connections to abnormalities in the body's overall immune response.

News • In vitro disease models

'Intrepid' research to advance cancer therapies

A major new initiative aims to enable the development of advanced, specific and highly reproducible human in vitro models for greater understanding of disease and the acceleration of new medicines.

News • AI-driven diagnostics

Philips and Cortechs.ai expand neuroimaging partnership

Philips and Cortechs.ai have extended their collaboration to integrate AI-enabled quantitative neuroimaging analytics directly into MR systems. The partnership aims to provide radiologists with automated, objective measurements of brain structures and lesions to support diagnosis and monitoring of neurological conditions.

News • Sex-specific dysregulation

Why women are three times more likely to get severe long Covid

New research reveals why women with long Covid — especially those who develop chronic fatigue syndrome — tend to experience more severe and persistent symptoms than men do.

News • Early thoracic malignancy screening

Developing a breath test for lung cancer with biosensors and AI

A biosensor that identifies volatile organic compounds (VOCs) in exhaled breath could be used in conjunction with AI to detect various thoracic cancers including lung cancer.

News • ST-segment elevation myocardial infarction (STEMI)

ECG-reading AI better detects severe heart attacks in emergency setting

In emergency settings, AI to analyze ECG data can improve detection of severe heart attacks, including those with unconventional symptoms, or atypical ECG patterns, and reduced false positives.

Article • Reshaping GI cancer care

Pathologists at the heart of precision oncology

Biomarker testing is ushering in a novel era of therapy personalisation for gastroesophageal and colorectal cancers, according to experts presenting at the 37th European Congress of Pathology in Vienna this September. During a session on state-of-the-art in gastrointestinal biomarkers, speakers outlined how targeted therapies and immunotherapies are transforming treatment options – but…

News • Proteins for personalized treatments

Tracking Duchenne muscular dystrophy with blood biomarkers

Newly discovered blood biomarkers may offer new options to track Duchenne muscular dystrophy (DMD) in a less invasive way than physical tests or biopsies. This could support more tailored treatments.

Article • Expert perspectives from ESC 2025

Faster, smarter, deeper: how new technologies redefine cardiac imaging

Cardiac imaging is evolving, and new techniques continue to uncover the secrets of the heart for cardiologists who know how to use them. At the ESC 2025 Congress in Madrid, four experts explored cutting-edge developments across different modalities. Ranging from AI-assisted ultrasound image acquisition and accelerated MRI protocols to advanced prognostic tools for CT and nuclear imaging, these…

News • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Blood test for ME/CFS unveiled

Chronic fatigue (ME/CFS) affects millions worldwide, but is poorly understood and has long lacked reliable diagnostic tools. Now, a new blood test claims to diagnose the condition with 96% accuracy.

News • Focus on adipose tissue metabolism

Endometrial cancer: visceral fat may drive aggressiveness

Using PET/CT imaging, researchers discovered that the biological activity of visceral fat may drive the progression of endometrial cancer, offering a novel angle for diagnosis and treatment.

News • Focus on AMPA receptor density

Molecular basis of Long Covid's “brain fog” uncovered

New insights on the mechanisms that cause “brain fog” in Long Covid patients: Researchers use a specialized brain imaging technique to identify a potential biomarker and therapeutic target.

News • Endocrinology

European study establishes leptin reference values across age groups

International research led by Leipzig and Ulm universities creates first standardized leptin reference values for all ages and weight classes, advancing personalized medicine

News • Diagnostics

Fast candida detection through sugar pattern analysis

Scientists created precise replicas of Candida sugar coats to understand immune responses, enabling fast bedside testing that could replace slow lab cultures.

News • Evaluating tadiotheranostic targets

Endometrial cancer: new markers for PET imaging

Researchers explored two promising new biomarkers as potential radiotheranostic targets for endometrial cancer. This could help identify patients who are likely to respond to targeted therapeutics.

Article • AI-powered prediction

Machine learning identifies cardiotoxicity risk in breast cancer patients

Researchers have developed a machine learning algorithm that uses cardiac MRI images to help identify breast cancer patients who may be at risk of cardiotoxicity during cancer treatment. The research, led by cardiologist Dr Paaladinesh Thavendiranathan from Toronto General Hospital University Health Network, was presented at the European Society of Cardiology's Cardio-Oncology Conference in…

Article • From H&E to multiplex

Self-learning AI: a boost for digital pathology

Self-learning artificial intelligence approaches are offering a number of advantages for digital pathology when compared to established AI options. The benefits, which range from greater speed and capacitive flexibility to ‘wholly interpretable’ analyses, were outlined at the Digital Pathology and AI Congress in London.

News • Neural anticipation of infection

Virtual health threats trigger real immune response

The mere fact of being exposed to a sick avatar in a virtual reality environment triggers a measurable immune response in humans, a multidisciplinary research team discovered.

Article • Advances in mobile monitoring

Wearable technology transforms laboratory medicine

Remote monitoring via microfluidic platforms, AI-assisted sensor systems, and more: Attendees of the Labmed Forum at Medica saw impressive examples on how wearable technology is becoming a transformative force in laboratory medicine to improve real-time monitoring of patients, covering widespread conditions such as diabetes, asthma and COPD. With an emphasis on remote monitoring, devices are…

News • Review explores bacterial impact

Vaginal microbiome holds untapped potential for women's health

The vaginal microbiome is a largely overlooked area of medicine that could dramatically improve outcomes for common infections, infertility and even cancer for millions of women, a new review finds.

News • Epigenetic biomarkers

Revealing risk of cardiovascular disease in type 2 diabetes

Type 2 diabetes greatly increases the risk of heart attacks, strokes, anginas, and other coronary heart diseases. Therefore, biomarkers to predict individual risk are needed, experts say.

News • Chronic obstructive pulmonary disease

One step closer to COPD population screening

A multicenter study involving leading hospitals across Spain, has confirmed that people with COPD show altered levels of specific metabolites in their blood.

Article • Blood-based biomarkers under scrutiny

BBB testing for universal Alzheimer’s screening? It’s complicated

Do laboratory tests using blood-based biomarkers (BBB) represent the next type of universally recommended screening tests for Alzheimer's disease (AD)? Experts curb the high expectations for this type of diagnostic tool.

News • Patient involvement enables research

Tumor vesicles as a promising biomarker for early cancer detection

Tumor vesicles may serve as early indicators of cancer and help monitor the effectiveness of treatments. Now, researchers discovered a new way to detect these vesicles.

News • Predictive phenotypes

Ovarian cancer: new insights into immune landscapes

Defining four different immunologic subtypes of recurrent ovarian cancers, researchers pave the way for more personalized treatment.

News • Rapid exosome isolation and detection

Researchers develop at-home skin patch test for melanoma

Melanoma testing could one day be done at home with a skin patch and test strip with two lines, similar to Covid-19 home tests, according to University of Michigan researchers.

News • Obsessive-compulsive disorder

Neural biomarkers for OCD discovered

Using electrodes implanted in the brain, researchers observed specific brain waves that could serve as a biomarker for obsessive-compulsive disorder (OCD) and are an important step towards more targeted treatments.

News • Raman spectroscopy and interpretable machine learning

AI-assisted tissue differentiation for smart surgical tools

By identifying the unique biological signatures that guide AI tissue classification, new research lays the foundation for smart surgical tools with the added feature of biomolecular-level precision.

News • The nose knows

Dogs successfully trained to sniff out Parkinson's disease

Two dogs have been trained to distinguish between sebum swabs from people with and without Parkinson’s disease. This is especially relevant, as a definitive diagnostic test remains elusive.

News • Neurodegenerative disease

Alzheimer's: middle-age brain biomarkers give an earlier shot at prevention

The earlier Alzheimer's disease is detected, the more effective treatments become. Now, a Finnish study shows that signs related to Alzheimer’s may already be found in the brain in middle age.

News • Assessment of tumour-infiltrating lymphocytes

Skin cancer: AI assistance helps pathologists identify melanoma

More consistent TIL assessments, more accurate patients' prognoses: New research shows how AI sharpens pathologists' interpretation of tissue samples for malignant melanoma.

News • Potential diagnostic medium

Saliva analysis could reveal risk of cancer, heart disease or Parkinson’s

Molecular markers in saliva could reveal the risk of a person developing major diseases such as cancer, cardiovascular diseases, diabetes and neurodegenerative diseases, new research finds.

News • Dual role of tau phosphorylation

Surprising find: Alzheimer's biomarker found in newborn brains

What do the brains of newborns and patients with Alzheimer's disease have in common? Researchers have discovered a surprising shared trait - which might provide new insights into the disease.

News • Dual targeting radioligand

“Smart missile” radiopharmaceutical shows promise against multiple cancers

New research makes a strong case for a new dual-targeting radiopharmaceutical, designed to attach to two vulnerable sites on cancer cells, enabling more precise and potent therapy.

News • Colorectal Cancer Screening

CT colonography proves more cost-effective than stool DNA tests

New research demonstrates CT colonography outperforms stool DNA testing in both clinical effectiveness and cost savings for colorectal cancer screening.

News • Genetic signature mapping

Diagnosing Parkinson’s from a blood sample

In a world first, researchers have identified a set of biomarkers that could someday make it easy to spot Parkinson's disease in a patient’s blood sample.

News • Barrier effect research

Using bacteria to improve microbiota resistance to pathogens

Microbiota composition can help prevent pathogenic bacteria from proliferating, known as the barrier effect. Now, scientists have identified seven bacteria involved, paving the way for new therapies.

News • CT-based deep learning-driven tool

Liver cancer segmentation and detection with 'SALSA'

Results of a new retrospective study demonstrate the potential of a novel, CT-based deep learning-driven tool to enhance liver cancer diagnosis, treatment planning, and response evaluation.

News • Retinal functional impairments as biomarkers

Eye exam shows potential for early detection of Parkinson's disease

Researchers from Université Laval discovered that the retina of people with Parkinson's disease responds differently to light than that of healthy people. This offers new diagnostic options.

News • Promising biomarker found

Broad rim lesions predict multiple sclerosis progression

A new biomarker for multiple sclerosis: the inflammatory cell rim from microglial cells surrounding brain lesions was found to directly correlate with the severity and speed of disease progression.

News • Reactions to noise as biomarkers

Tinnitus diagnosis via AI-powered face scan

Pupil dilation and involuntary facial movements could provide a window into diagnosing tinnitus. A new method uses AI to detect minuscule reactions to various sounds and noises.

News • Combining spatial transcriptomics, pseudotime and machine learning

More precise than PSA: New biomarkers for prostate cancer found in urine

Using AI and extensive analyses of gene activity in tumours, researchers have found new, precise biomarkers to diagnose prostate cancer at an early stage through a simple urine sample.

Article • Exploring imaging advances and their impact on radiographers

‘The future of breast MRI is bright’

Breast MRI has emerged as a powerful diagnostic tool, particularly for women with dense breast tissue where traditional mammography faces limitations. In her presentation at ECR 2025, radiographer Hanna Kalliomäki highlighted several technological advances transforming breast cancer detection and diagnosis. From time-saving abbreviated protocols and AI-assisted analysis to contrast-free…

News • Blood-based marker P-tau217

Simple, yet effective way to early detect Alzheimer's disease

A new, simpler and cheaper analytical method for the early detection of Alzheimer's disease could help bring blood tests into the healthcare system globally, according to a new study.

News • Study on diagnostic shortcomings

Parkinson's disease: one in six diagnoses turns out to be inaccurate

A new study found that a significant proportion of Parkinson's disease diagnoses are later corrected. The results demonstrate the need for improved diagnostic processes.

News • Self-sustaining thermoelectric system

e-Tattoo detects infections from skin temperature

An international research team has developed an intelligent device capable of monitoring the skin continuously and accurately detect temperature variations associated with inflammation and infection.

Article • Digital pathology discussion panel

The AI tools pathologists want and need

The evolving role of AI tools in digital pathology was explored at an open discussion during the annual Digital Pathology and AI Congress in London with a high-level panel of practitioners looking at current and future technology options. The panel of pathologists, scientists and academics from Europe and the USA assessed the tools they currently use and are available to them, and those they…

News • Nuclear imaging

PET radiotracer reveals inflammation in the brain

Using the COX-2 enzyme, a new PET imaging approach offers a never-before-seen view of inflammation in the brain, opening the door for clinical and research settings for various brain disorders.

News • Cardiac event marker

Coronary artery calcium score: useful regardless of age

A large new study of more than 40,000 patients finds that a zero coronary artery calcium score continues to be an accurate indicator of a low risk for a coronary heart event even as a person ages.

News • Deep learning-based CVD risk prediction

Mammography and AI open a new window into heart health

New findings show how AI-assisted mammography may not only reveal breast cancer, but can also assess calcium buildup in the arteries within breast tissue—an indicator of cardiovascular health.

News • Triple-negative breast cancer

Novel radiotracer identifies TNBC biomarker

A new PET tracer has the potential to play a critical role in the diagnosis, treatment, and monitoring of aggressive triple-negative breast cancer (TNBC), improving clinical outcomes for patients.

Article • Detection of neurodegenerative condition

Developing blood biomarkers to diagnose Alzheimer’s disease

There is no known cure for Alzheimer’s disease (AD), although prescription drug-based treatments that can slow AD progression in some patients are starting to enter clinical use. Biomarkers, quantifiable characteristics of biological processes or pathological conditions of the body, are making it possible to help identify and measure the presence and extent of AD and its degenerative…

Article • Promising, but in need of further validation

Implementation challenges of blood biomarkers for Alzheimer’s disease

Blood-based biomarker (BBB) tests may represent the best weapon to combat the soaring rates of Alzheimer’s disease (AD) throughout the world. Existing clinically validated tests are currently deployed to facilitate diagnosis, to monitor disease and effectiveness of treatments, to quantify progression, and to determine if a patient is appropriate for treatment or participation in a clinical…

News • From the heart to the mind

'Dorian Gray' to uncover link between CVD and MCI

Around one third of people with cardiovascular disease (CVD) also have mild cognitive impairment (MCI), yet the condition is often undiagnosed. A new project aims to untangle this MCI-CVD connection.

News • Reseach on neurofilament light chain proteins

ALS: Improving diagnosis and management with new blood test

A new blood test, using neurofilament light chainproteins as biomarker, could lead to better diagnosis and management of amyotrophic lateral sclerosis (ALS).

Article • Spanish registry offers unprecedented data

ROSSETTI: Towards a more personalized treatment of stroke

The boom in interventional radiology procedures has enabled great strides in ischemic stroke management. But while a myriad of techniques are available, the challenge remains in choosing the most appropriate thrombectomy treatment on the spot, according to Jordi Blasco Andaluz, a neuroradiologist at Hospital Clinic Barcelona. The new ROSSETTI registry is designed to change this.

News • Cell-free tumor DNA analysis

Liquid biopsy to unlock breast cancer treatments

New research highlights the potential of circulating tumor DNA (ctDNA) analysis as a non-invasive method to identify actionable biomarkers for breast cancer, enabling individualized therapies.

News • Multi-omics-based prediction

Pancreatic cancer: 'biomarker panel' brings hope for early detection

The discovery of a 'biomarker panel' could have a profound impact on the ability to identify patients at risk of developing pancreatic cancer at an earlier stage, researchers hope.

News • Hyper-elevated RNAPII detection

New biomarker predicts aggressiveness of brain, breast cancer

Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting the aggressiveness of meningioma brain tumors and breast cancers.

News • Age-related cellular and molecular changes

How aging breast tissue shapes breast cancer risk

Researchers have created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.

News • Micro Immune Response On chip (MIRO)

Replicating tumours to assess cancer immunotherapy efficacy

Researchers have developed a new kind of tumour-on-a-chip, which gives insight into the tumour environment and immunotherapy response. The device has been successfully tested on breast cancer samples.

News • Research on RAD51 biomarker

Next-generation sequencing for personalizing prostate cancer treatment

Certain gene alterations can serve as a prognostic and predictive biomarker for prostate cancer. Now, researchers confirm the feasibility of using NGS on this marker for precise patient stratification and treatment selection.

News • Quantification of serum biomarkers

Early detection of lung cancer with low-cost biosensor

A sensor, similar to glucose monitoring devices, detects lung cancer biomarkers from a blood sample in just 40 minutes. The technology has potential to identify at-risk patients and tailor treatments.

News • Osteosarcoma research

Driver behind aggressive bone cancer identified

By analysing the largest collection of whole-genome data from osteosarcoma patients, researchers identified a driving mechanism behind the aggressive development of these bone cancer tumours.

News • Research on MRD in tongue cancer

Understanding chemotherapy resistance in oral cancers using organoids

Tongue cancer cells can become resistant to chemotherapy under certain circumstances. Investigating these mechanisms, researchers shed light on promising avenues toward new treatments for this cancer.

News • Checkpoint inhibitor immunotherapy efficacy

AI tool uses routine blood tests to predict cancer immunotherapy response

Researchers have developed an AI-based model to better predict whether cancer patients will benefit from immunotherapy — using only routine blood tests and clinical data.

News • Precision oncology research

Breast cancer chemotherapy receives boost from localised magnetic fields

Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of breast cancer chemotherapy while reducing its harmful side effects.

Article • Keynote on integrated diagnostics

Predicting – and shaping – the future of modern pathology

Complex diseases could require complex biomarkers for accurate diagnosis in the years ahead, according to a leading pathologist. In a keynote address to the 36th European Congress of Pathology in Florence, Italy, Professor Manuel Salto-Tellez highlighted this as one of the major future challenges for the discipline. However, he also believes pathologists will sit at the core of modern medicine.

News • New approach to combat treatment resistance

How chemotherapy affects ovarian cancer tumours

Research offers new insights into harnessing the immune system to combat ovarian cancer. The findings could lead to personalized therapies that target the right patients at the right time.

News • Functional connectivity imaging

fMRI brain scan predicts effectiveness of spinal cord surgery

Spinal cord stimulation is performed for patients with chronic pain. However, for some patients, the procedure is not effective. A new method involving fMRI could help predict success.

Article • AI-assisted image analysis

More accuracy in brain tumour segmentation

Precise segmentation of anatomical structures greatly benefits cancer diagnosis. Using AI and deep learning methods, researchers are developing a high-precision 3D viewer software for medical image data.

News • Deep learning advances

New AI model for cell segmentation and classification

US researchers have developed a comprehensive deep learning AI model designed to more accurately identify and classify cells in high-content tissue images.

News • Incidentaloma detection

Liquid biopsy as diagnostic tool for pancreatic lesions

New research highlights the potential of liquid biopsy in diagnosing pancreatic incidentaloma - lesions which can occasionally signal pancreatic cancer in its earliest stages.

Article • Between good practice and financial pitfalls

Delivering molecular pathology at lower costs

Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.

News • Tradefair programme overview

Don't miss: Trends and innovations at the Medica 2024 Health IT Forum

How can innovations help to master challenges and demands in healthcare? This central question will be addressed at the Medica Health IT Forum, an established part of the programme at the trade fair.

Article • Molecular meets digital

Single-cell multiplex imaging: a powerful tool for digital pathology

Multiplex imaging can play a critical role in unravelling the tumour microenvironment. The potential and benefits of the emerging approach – a way to extract information from human tissue samples by visualising many more biomarkers than traditional microscopy – was highlighted in presentations during the 36th European Congress of Pathology in Florence, Italy. Speakers also discussed novel…

News • Catch some EVs

Liquid biopsy to improve cancer diagnosis

A new method could open new avenues to quick, affordable cancer diagnosis, US researchers report. The method uses ultrathin membranes to capture extracellular vesicles.

Taipei showcases cutting-edge medical devices & diagnostics at Medica 2024

Taipei City is set to make a splash at the Medica 2024 trade fair. The city's Department of Economic Development has curated an exhibition area, featuring six innovative biotech companies.

Interview • Congress showcases advances

Making immunotherapy work for more cancer patients

Immunotherapy has become the most promising strategy for treating several cancers, but its effectiveness is still very uneven. Three researchers explain how research is being done to change this.

News • Cancer treatment advances

USC study findings: early blood test forecasts survival rates in patients with metastatic prostate cancer

A new study found that measuring circulating tumor cells (CTCs), rare cancer cells shed from tumors into the blood, is a reliable way to predict later treatment response and survival prospects with metastatic prostate cancer.

News • Transport of minuscule gold particles

Nanoparticles could detect kidney disease better than blood tests

Before administering certain drugs, doctors check a patient’s kidney function by testing their blood urea nitrogen and creatinine levels. New research shows that gold nanoparticles might give more accurate results.

News • Groundwork for new treatments

Fibrosis a prognostic biomarker for HER2-negative breast cancer

A new study confirms fibrosis as a prognostic indicator in HER2-negative, the most common breast cancer, and opens the way to antifibrotic drug treatments.

News • Neurodegenerative diseases

Tauopathy or Alzheimer's? Biomarker and PET imaging for improved diagnosis

Researchers have identified biomarkers that, in conjunction with PET imaging, enable doctors to reliably distinguish between primary 4-repeat tauopathies and Alzheimer's disease.

News • Checkpoint inhibitor research

Five key factors predict response to cancer immunotherapy

Only 20-40% of patients respond positively to immunotherapy, and these rates vary across different types of cancer. Researchers now identified five key factors that determine response and survival.

Article • Oxford debate at senology congress

DCIS: pros and cons of radiotherapy

Radiologists and gynaecologists entered a veritable bout during the Oxford debate at the 43rd annual congress of the German Senologic Society in Dresden. Controversy was sparked by the question of whether all patients with a ductal carcinoma in situ (DCIS) should undergo radiotherapy.

News • Women's health

Endometriosis: exploring promising diagnostic tools

Endometriosis can cause abdominal pain and cramping before, during and after menstruation, and may lead to infertility. Now, researchers identified promising approaches for better early diagnosis.

News • Promising research on oral rinse-based test

Wash, rinse – detect head and neck cancer?

Can a mouthwash-based test help predict head and neck cancer recurrence? A new study suggests it might.

News • Staging and monitoring tool

Diagnosing lung disease with quantitative ultrasound parameters

Using conventional ultrasound, researchers have developed a model that determines whether conditions such as fibrosis or edema are present in the lungs, and gives information about the severity.

News • Glycopeptide probes for antibody detection

New method speeds up pancreatic cancer detection

A new method could lead to a significantly more precise and reliable diagnosis of pancreatic cancer. It is based on the selective detection of specific antibodies in blood samples.

News • DTI for concussion patients

Advanced brain MRI to reveal ‘hidden disease’

Just a concussion? Head injury can lead to persistent symptoms, yet CT scans often fail to identify these cases. Researchers explore the potential of diffusion tensor imaging for better diagnostics.

News • Tumor assessment via chromatin imaging

From DCIS to IDC: AI identifies breast cancer stages

Researchers at MIT and ETH Zurich developed an AI model that identifies certain breast cancer stages likely to progress to invasive forms of cancer.

Opinion article • Wearable medical devices

Sweat analysis reveals a wealth of health information

Diagnosis and monitoring medical conditions, including cancer, diabetes, heart disease, and infections: In this opinion article, Alix Joseph (Linxens) explores the potential of sweat analysis.

News • Tumour infiltrating lymphocyte measurement

Breast cancer: AI tool predicts which DCIS cases become invasive

Ductal Carcinoma in Situ (DCIS) often develop into more invasive forms of breast cancer. To predict which DCIS patients are likely to be affected, researchers have developed an analytic AI-based tool.

News • What patients can expect

Alzheimer's: New method to predict cognitive decline

Researchers have developed a model to predict cognitive decline in patients with mild cognitive impairment or mild dementia due to Alzheimer's disease. The next step is an app that uses this model.

News • Focus on microproteins

Researchers find potential target for liver cancer vaccine

Microproteins hold great promise, according to new research: Since they are only expressed by liver tumor cells, the proteins could serve as a potential target for cancer vaccine development.

News • Circulating tumor extracellular vesicles

Metastatic prostate cancer: better monitoring with new liquid biopsy method

A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.

News • Research on physical conditions

Exploring the link between obesity and cancer risk

Why does obesity increase the risk of cancer and possibly metastasis? Researchers in Spain are currently investigating this very question.

News • "Candycrunch"

AI and mass spectrometry to find cancer clues at lightning speed

Researchers have developed an AI model that increases the potential for detecting cancer through sugar analyses. The AI model is faster and better at finding abnormalities than current methods.

News • Biomarkers enhance early detection

Parkinson's: blood test predicts disease up to seven years before symptoms

A novel blood test shows promise to predict Parkinson's disease in risk patients up to seven years before the typical motor symptoms appear.

Article • Challenges and opportunities

Molecular pathology in Europe: in search of standardization

Tackling standardization of molecular pathology at a European level remains a major challenge, according to speakers at the 35th European Congress of Pathology in Dublin. One leading expert warned it would be ‘very difficult’ to achieve, though the session also heard about potential solutions such as educational steps to consistently train future pathologists at a high and consistent level.

Article • Technology applications in diagnostic imaging

How digital twins will support the radiologist of the future

Digital twin technology can transform clinical practice by aiding patient-specific prediction and supporting personalized treatment models. Expert speakers at an ECR 2024 session in Vienna focussed on how radiology will play a leading role in the advance through data acquisition via a range of imaging modalities.

News • Antibacterial protein as therapeutic target

Pancreatic cancer: new approach for immunotherapy

Pancreatic cancer stem cells exploit an antibacterial protein to evade the immune system. Removing this protein could pave the way to more effective immunotherapy, new research suggests.

News • Integration of microanalysis chips

Establishing microfluidic control technology for blood testing devices

A research group established a microfluidic control technology that can be applied to small blood testing devices and consequently developed a novel integrated immunoassay device.

News • Success of aRCC treatment

New biomarker to better predict immunotherapy response in kidney cancer

Immunotherapy increases survival rates in kidney cancer, but does not work for everyone. A research team developed a new method to predict which patients will benefit from it.

Article • Pros and cons of diagnostic techniques

Liquid biopsy vs. tissue biopsy: Getting the best of both worlds

Tissue biopsy and liquid biopsy can increasingly be used as complementary or alternative approaches, with advantages and limitations to each. While speakers at the recent 35th European Congress of Pathology in Dublin were quick to highlight that liquid biopsy was not about to replace tissue biopsy, the focus looked at the benefits and challenges of each through the lens of four expert speakers.

News • Axon vulnerability to damage

Male and female brains are different – and so are the effects of concussions

Structural differences in male and female brains might explain why women are more prone to concussions and experience longer recovery from the injury than men, according to a new preclinical study.

Article • Advancements in endoscopy

Enhancing diagnosis and disease monitoring for ulcerative colitis

Endoscopy is pivotal in diagnosing and managing ulcerative colitis. Recent technology advances allow for early cancer detection, precise disease assessment and targeted biopsies, improving diagnosis and monitoring. The following article takes a look at the latest advancements.

News • Three-dimensional tissue processing

Pathology performs leap into 3D with AI

Adding a new dimension to pathology: Researchers explore new, deep learning models that can use 3D pathology datasets to make clinical outcome predictions for curated prostate cancer specimens.

Article • "Timely" study

Improved care after heart attack on AI-powered telemedicine platform

Coronary artery disease causes more than 1.8 million heart attacks each year in Europe. In most cases, rehabilitation helps the patients to return to their everyday life. But what happens once the patients have left the rehab clinic?

News • Urine-based diagnostics

New prostate cancer test to help avoid unnecessary biopsies

US researchers have developed and validated a new urine-based test for prostate cancer, which was shown to meaningfully reduce unnecessary prostate biopsies while providing highly accurate detection.

News • Immunological improvement

How long is long Covid? New research hints at timeframe

New research provides cause for optimism that long Covid can resolve over time. Following people from the first wave of Covid-19, it monitored the longevity of immune abnormalities after an infection.

Article • Pharmaceutical research

Boosting biomarker detection with digital pathology

Digital pathology can be used to great effect in pharmaceutical research: it can accelerate analyses, give deeper insights into cellular mechanisms, and enable better understanding of their role into clinical development. This potentially offers clearer predictions on how patients may respond to treatment and lead to personalized therapies.

Article • Photon-counting CT, strain imaging, 4D flow MRI

How new technologies shape the future of cardiovascular radiology

New approaches to cardiovascular radiology are evolving to help clinicians gain an increasingly better insight into heart conditions. Latest developments in cardiovascular radiology include myocardial strain imaging, 4D flow and photon-counting CT technology. An ECR 2024 session shone the spotlight on these areas of cardiovascular imaging with expert speakers outlining the pros and cons of each.

News • Bioinformatics

New tool identifies chromosomal instability in cancer cells

A new detection tool is designed to contribute to improving tumour research and classification by identification and quantification of chromosomal instability in the nuclei of cancer cells.

Article • Interdisciplinary diagnostics

Crossing the radiology-pathology boundary

In diagnostics, there used to be a hard divide between radiology and pathology, where methods were largely considered incompatible with one another. However, to pave the way for next-generation diagnosis, Professor Regina Beets-Tan urged both sides to come out from their trenches and appreciate the synergies the fields have to offer. In her presentation at the European Congress of Radiology (ECR)…

News • Heart rhythm disorder

Stroke prevention: experts recommend routine atrial fibrillation testing

Atrial fibrillation is the most common heart rhythm disorder globally. Patients at high risk for AF, such as those with heart failure or prior stroke, should be tested at every GP visit, experts say.

News • Chemotherapy and novel surgery technique

Study explores new approach to 'inoperable' pancreatic cancer

US oncologists are exploring a new combined chemotherapy and surgical approach to safely remove advanced pancreatic tumors that were previously considered inoperable.

News • Voxel-wise classification

Deep learning tool uses MRI to enhance brain tumor diagnosis

A novel AI-based, non-invasive diagnostic tool enables accurate brain tumor diagnosis, outperforming current classification methods. The tool leverages MRI information to aid clinical decision making.

News • Personalised oncology

New platform to significantly reduce cancer drug testing and screening time

In a breakthrough for personalised oncology, scientists have developed and demonstrated a novel platform that can significantly reduce the time needed to determine the efficacy of anti-cancer drugs.

Article • Proof-of-concept study

First test for the early detection of head and neck cancer being developed

Most head and neck tumours are discovered in late due in part to the fact that there is no established method for early detection. To close this gap, a team at oncgnostics, a biotechnology company based in Jena, Germany, is participating in a study which aims to develop an early detection test.

Article • Imaging in characterisation and classification of tumour types

Taking a closer look at breast cancer

Breast cancer has no “one size fits all” therapy approach: subtypes differ significantly in malignancy, progression, and treatment response. Therefore, the more is known about the type of carcinoma in a patient, the better the outcome. At the annual scientific EUSOBI meeting in Valencia, Dr Ramona Woitek pointed out the potential of novel imaging techniques and computational image analysis…

News • Pan-cancer proteogenomics

Characterizing the immune landscape in cancer

Researchers have unveiled a detailed understanding of immune responses in cancer, potentially paving the way for the development of new therapeutic strategies, the team hopes.

News • Saliva test device

Breast cancer screening: Biosensor could offer alternative to diagnostic imaging

A newly-developed biosensor could be an alterative to MRI and mammography for breast cancer screening. The handheld device uses saliva on test strips to determine whether cancer is present.

Article • Addressing an unmet need

MCED: a simple test for widespread early detection of cancer

Academic labs and biotech firms pioneer multi-cancer early detection with emerging technologies. Screening for multiple cancers with a simple blood or urinary draw could be a game-changer. Two research teams in particular have advanced the field.

News • Updated diagnostic criteria

Parkinson's: New three-type classification

Three disease subtypes, based on causes rather than symptoms: A new classification model for Parkinson's disease aims to pave the way for better diagnostics and therapies.

Article • UK research project

"Our Future Health": Shifting from curative to preventive care

As a result from better living standards and medical advances, population longevity increases – a development which, paradoxically, current healthcare systems are ill-prepared for, Sir John Bell points out. The UK’s Our Future Health programme, which he chairs, exemplifies the paradigm shift to a prevention-centered healthcare approach.

Article • Experts explore impact of technology

AI in radiology: helper or bane of society and the environment?

The climate crisis and AI – arguably two of the most hotly-debated and relevant topics of our time – share an intricate relationship: While computation of complex AI routines commands an immense carbon footprint, it is these algorithms that might be the very key to mitigate the effects of global warming. In a dedicated session at ECR 2023, radiologists explored the societal and environmental…

News • Mental health biomarkers

Could a blood test identify suicidal thoughts?

A new US study suggests a new way to personalize mental health care: They found compounds in the blood of people with depression and suicidal ideation that could be detected using a blood test.

News • CTC, ctDNA and exosomes in PCa management

Prostate cancer: Blood-based liquid biopsies yield valuable information

US researchers discuss three blood-based liquid biopsies, namely circulating tumor cells, circulating tumor DNA and tumor-derived exosomes, as they relate to prostate cancer management.

News • Tissue oxygenation

Photoacoustic imaging for better diagnoses of ovarian cancer

Researchers and clinicians at Washington University in St. Louis found a way to improve diagnostic accuracy of potentially cancerous lesions in the ovaries and adnexal regions, or the fallopian tubes.

CSF and Alzheimer’s Disease Diagnostics

CSF false-bottom tube

Highlights:Excellent recovery thanks to low-binding propertiesRoutine-use primary container for sample collection and automated analyticsPatient-friendly sample volume of 2.5 mlCost-effective alternative to PET scanReliable pre-analytics for optimum sample integrityThe new CSF false-bottom tube (art. no.: 63.614.625) meets the requirements for reliable pre-analytics in Alzheimer’s disease…

Integrated Hematology

DxH 900 Hematology Analyzer

Dimensions: 755.7 × 1,740 × 828 mm (w × h × d)Weight: 254 kgSample throughput: Up to 100 samples / hPower consumption: 520 WHighlights:The DxH 900 hematology analyzer is ideal for mid- to high-volume clinical laboratories performing complete blood count and white blood cell differential tests while minimizing repeat testing, allowing you to deliver the…

Blood Cell Counter

Early Sepsis Indicator

Highlights:A first-of-its-kind, hematology-based cellular biomarker, the FDA cleared Early Sepsis Indicator is designed to help emergency department physicians identify patients with sepsis or at risk of developing sepsis within 12 hours of ED presentation. Results are automatically reported as part of a routine complete blood count (CBC) with differential for adult emergency department…

Blood Cell Counter

DxH 690T

Dimensions: 755.7 × 1,740 × 828 mm (w × h × d)Weight: 254 kgSample throughput: Up to 100 samples / hPower consumption: 520 W*Highlights:The DxH 690T offers all the benefits of Beckman Coulter’s flagship DxH 900 hematology analyzer to mid-size labs, including an industry leading 93 % first pass yield and the Early Sepsis Indicator. The only…

News • Point-of-care neurodiagnosis

Eye-safe laser technology to diagnose traumatic brain injury

Researchers from the University of Birmingham have designed and developed a novel diagnostic device to detect traumatic brain injury (TBI) by shining a safe laser into the eye.

News • Based on image-based flow cytometry

Rapid test to predict severe Covid-19 infections

Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe Covid-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a Covid-19 infection. This will allow physicians to adjust treatment at an early stage. The researchers used a method…

News • Funcional brain imaging

New design increases fMRI resolution tenfold

Ten times more detail than current 7T scanners, over 50 times more than 3T: A new type of functional MRI will allow neuroscientists to more precisely localize and trace brain networks.

News • Opportunistic screening using chest X-rays

AI identifies non-smokers at high risk for lung cancer

Incidence of lung cancer among people who never smoked is rising. A new AI tool opens the door for opportunistic screening for this group, using existing chest X-rays in the electronic medical record.

News • Biosensor

Wireless, handheld device to detect Alzheimer’s and Parkinson’s biomarkers

A team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer’s and Parkinson’s Diseases. The biosensor can also transmit the results wirelessly.

Article • Latest advances

Lab-on-a-chip systems in 2023: The micro-lab revolution

Faster, more accurate and cost-effective testing: Experts outline the beginnings and evolution of “lab-on-a-chip” technology, and its benefits for advanced and next-gen operational platforms.

News • Predictive psychiatry

Brain imaging finds biomarkers of mental illness

In a new study, researchers use a very large dataset to identify predictive brain imaging-based biomarkers of mental illness in adolescents.

News • Prognostic model

New urine-based test offers hope for bladder cancer patients

In a new study, researchers from Fudan University have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.

News • RENACER repository

Brain cancer tissue samples to gain new insights

A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.

News • Platform for new companies

MEDICA 2023: Start-ups are shaking things up

MEDICA trade fair (Nov 13-16, Düsseldorf) is a major event for start-ups entering the health sector. Hundreds of young developers seek business contacts for cooperation concerning funding, production, approval, marketing or sales of their products.

News • AI-based imaging and reporting solutions for MRI

Philips partners with imaging biomarker specialist Quibim

Philips and Quibim have signed a multi-year agreement to work on an integrated solution including an AI-based software to automate real-time prostate gland segmentation in MR images.

News • The role of arginine

Cancer research: Metabolite drives tumor development

University of Basel scientists have discovered that high levels of the amino acid arginine drive metabolic reprogramming to promote tumor growth. This could lead to improved liver cancer treatment.

News • Neuro research

3D printing method shows promise for repairing brain injuries

University of Oxford researchers demonstrated that neural cells can be 3D printed to mimic the architecture of the cerebral cortex. This could be used in patients after brain injuries.

News • New imaging agent

HER2-positive breast cancer: Whole-body PET/CT predicts targeted therapy response

A new imaging agent can predict early metabolic response to HER2-targeted treatment in metastatic breast cancer patients, according to new research published in the Journal of Nuclear Medicine.

News • Detecting dopamine deficiency in the brain

A new biomarker to identify Parkinson's and related diseases

Could a single biomarker detect all types of diseases related to dopamine deficiency in the brain? According to a Swedish research group, such a marker may have just been found.

Article • Five-year EU project to avoid heart damage in oncology patients

Cardiac collaterals in breast cancer therapy

Modern cancer therapies are tough on the tumours, but often, also on the heart of the patients. The “CARDIOCARE” project aims to reduce the cardiac burden of anti-cancer therapies through more patient-tailored treatment approaches. At the ESC cardiology congress, Professor Katerina Naka from the project’s consortium explained why older patients are at the highest risk of cardiotoxic…

News • Injury of non-cancer cells identified as trigger

Breast cancer recurrence: Could chemotherapy cause what it's trying to stop?

Chemotherapy can be an effective means to fight breast cancer, but under certain circumstances, the treatment can cause dormant cancer cells to re-awaken, new research finds.

News • Biomarker-based predictions

AI drives precision oncology for colorectal cancer

For the first time, researchers show that AI-based predictions can deliver comparable results to clinical tests on biopsies of patients with colorectal cancer (CRC).

News • PFAS as risk factor

Researchers explore link between ‘forever chemicals’ and breast cancer

Can per- and polyfluoroalkyl substances (PFAS) increase the risk of breast cancer? A new study by US researchers examines the effects of the so-called “forever chemicals”.

News • Radiograph evaluation

AI uses chest X-rays to determine "true" age of a patient

Osaka Metropolitan University scientists have developed an advanced AI model that utilizes chest radiographs to accurately estimate a patient’s "true" age.

News • Biopharmaceutical business

Precision approach to significantly reduce R&D costs for cancer drugs

A new analysis exploring the finances of bringing new cancer drugs to market has found that precision oncology drugs could be $1 billion cheaper to develop than non-precision drugs.

Article • Oncology imaging

The expanding role of CT in lung cancer management

While screening programs for several of the commonest cancers are now well established, lung cancer screening has yet to reach anywhere near the same proportion of at-risk patients.

News • Microfluidics and electrochemical transduction

Paper-based device for rapid diagnosis of lung diseases

A new device that combines microfluidics on paper, electrochemical transduction and immunoassays on magnetic nanoparticles is useful for easy and rapid diagnosis of lung diseases.

News • Presented at AAIC

New guidelines for diagnosing Alzheimer's

The International Alzheimer's Congress (AAIC) in Amsterdam saw the presentation of new guidelines for diagnosing Alzheimer's disease - with blood biomarkers taking a central role.

News • Sars-CoV-2, flu, RSV and other viruses

Proof-of-concept air monitor detects coronavirus variants in 5 minutes

Combining aerosol sampling and ultrasensitive biosensing, researchers have created a real-time monitor that can detect any of the Sars-CoV-2 virus variants in a room in about 5 minutes.

News • Molecular and immunofluorescence imaging

Orion: A new tool for diagnosing cancer

Researchers at Harvard Medical School developed a new tool that promises to improve the way pathologists see and evaluate a tumor by providing detailed clues about the cancer.

Article • Cancer patients at risk

Blood test detects risk of neurotoxicity from CAR T-cell therapy

Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy treatment that re-engineers a patient’s own T-cells to help them attack malignant tumour cells. It has been very effective in the treatment of blood cancers, including certain types of leukaemia and lymphoma. However, two serious side effects are common as a result of the treatment: cytokine release syndrome (CRS) and immune…

News • Counteracting neuroinflammation

Multiple sclerosis: Why women get better when pregnant

Women suffering from multiple sclerosis temporarily get much better when pregnant. Researchers have now identified the beneficial changes naturally occurring during pregnancy.

News • Beyond polygenic risk scores

Adding blood biomarkers to genomics to better predict common disease risk

New research suggests that combining blood biomarkers with genomic information more accurately, cost-effectively predicts the risk of developing diseases.

News • Chronic myeloid leukaemia

CML therapy response predicted by AI "crystal ball"

AI could find critical biomarkers that predict non-response to conventional treatment in patients with chronic myeloid leukaemia (CML) more quickly, researchers in Singapore find.

News • Prostate cancer detection

Personalized PSA screening may improve accuracy

The accuracy of prostate-specific antigen (PSA) screening can be improved by including genetic factors that cause changes in PSA levels not associated with cancer, according to a multi-center study.

News • Circulating biomarkers

Blood tests shows brain impact of neurosurgery

Damage to the brains of patients operated on for brain tumors may be assessed by measuring biomarkers in the blood pre- and postoperatively, a new study from the University of Gothenburg shows.

News • HSNCC treatment stratification

Head and neck cancer: using organoids for personalized therapy

Researchers from the Organoid group (Hubrecht Institute) and UMC Utrecht have developed a biobank with organoids derived from patients with head and neck cancer (HNC).

News • Bias in datasets

Diversity is a challenge for rare disease-detecting AI, study finds

Most AI techniques for rare disease diagnosis use anthropometric measurements of European origins, ignoring the genetic and morphological diversity of humans, a new study finds.

Advanced tissue staining meets standardisation

It is crucial that labs can rely on their slides for a seamless – and accurate – diagnosis. With many more commercial instruments focusing on flexibility and choice, these qualities are difficult to separate from subjectivity and complexity.

News • Autism spectrum disorder

Identification of differences in the behavior and brain connectivity among patients with autism spectrum disorder

Autism spectrum disorder (ASD) is a developmental disorder associated with difficulties in interacting with others, repetitive behaviors, restricted interests and other symptoms that can impact academic or professional performance.

News • Genetics & Neuroscience

Improvement of stroke diagnosis and treatment through specific genes

Genes are full of clues about a person's health and might also show the way for stroke recovery.

News • Oncology & health informatics

Colon cancer: AI tool predicts survival, treatment response

A new artificial intelligence model could bring much-needed clarity to doctors delivering prognoses and deciding on treatments for patients with colorectal cancer.

News • Parkinson disease detection

Low-cost sensor detects early-stage Parkinson's disease in biological samples

Researchers at the University of Campinas and the Federal University of São Carlos in Brazil have developed an electrochemical sensor that detects Parkinson's disease at different stages.

News • Oncology & Cancer

Research uncovers alternate mechanism for producing key protein in metastatic prostate cancer

Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient's metastatic prostate cancer.

News • Promising biomarker found

Who will develop long Covid? It's in the blood

New research has found molecular signature differences in the blood of patients who fully recover from Covid-19 and those who develop long Covid.

News • Radiotherapy trial

Prostate cancer: radical approach greatly reduces treatment visits

A new clinical trial has shown that men diagnosed with prostate cancer can benefit from ‘radical radiotherapy’ that delivers treatment in five hospital visits instead of the typical 20.

News • Blood cancer research

Novel disease models for multiple myeloma

A team of scientists has successfully generated genetically defined mouse models for two subtypes of multiple myeloma. This will contribute to a better understanding of how the disease develops in humans.

News • Earlier detection and treatment

Exploring the potential of X-ray imaging for IPF

Carestream Health is funding and participating in an innovative pilot with OSIC that could lead to radiographs providing an early window into manifestations of IPF that are currently undetected.

Article • Cervix, vulva and vagina

More certainty with methylation tests for early detection of cancer

A second-generation lab test for early detection of cervical cancer is the most recent addition to Oncgnostics’ portfolio. In particular, the company’s solution will help women in countries with limited cancer screening. Moreover, new research on the early detection of vulval and vaginal cancer might soon enable the development of tests for these cancers.

News • Primary tumor or metastasis?

Deep learning and radiomics for precise differentiation in brain tumors

The distinction between primary tumors and metastases can be made quickly and accurately in brain tumors using radiomics and deep learning algorithms, a new study shows.

Video • Early detection of dementias

Promising sensor to screen for Alzheimer's

Canadian researchers are developing a new, ultra-sensitive biosensor to screen for Alzheimer’s disease and other diseases. The device has successfully completed the proof-of-concept stage.

News • Deep learning analysis of X-rays

AI used to triage patients with chest pain

Artificial intelligence (AI) may help improve care for patients who show up at the hospital with acute chest pain, according to a new study published in Radiology.

News • Neurodegeneration assessment

New blood test differentiates Alzheimer’s disease from other dementias

A new blood test that can track and follow the neurodegeneration in Alzheimer's disease - and exclude other dementias.

News • Ergothioneine levels

Blood biomarker to predict cognitive impairment and dementia

Identification of elderly persons at risk of developing cognitive impairment and dementia could be made possible by examining ergothioneine levels in the blood, researchers from Singapore find.

Article • Image augmentation, interpretation and evaluation

AI in multimodality hybrid imaging: a diamond in the rough

AI-based models for multimodality hybrid imaging have the potential to be a potent clinical tool but are currently held back by a lack of transparency and maturity, says Dr Irène Buvat, from the Laboratory of translational Imaging in Oncology, Institute Curie in Paris, France.

News • MCED test

Groundbreaking new method for multi-cancer early detection

An international study shows that a new method can easily find multiple types of newly formed cancers at the same time – including cancer types that are difficult to detect with comparable methods.

News • High-sensitivity blood test

New cancer testing method to make regular monitoring affordable

Scientists from Singapore discovered a novel low-cost method of testing for cancers. The test sequences heated clinical samples to isolate cancer-specific signatures found in a patient’s blood.

Article • Assistance and decision-making systems

Artificial intelligence for preoperative planning

In surgery, artificial intelligence (AI) is applied mostly in imaging, navigation, and robotic intervention. However, AI can also play a major role in preoperative planning. Objective decisions-making, optimal utilisation of operating theatres and less overtime are additional advantages that are achieved with the use of AI in surgery.

Article • AI-based personalized medical care

I³lung: EU launches lung cancer initiative

This summer, The European Commission launched I3lung, a new research initiative as a part of Horizon Europe, the EU’s research and innovation program. This research initiative aims to create a cutting-edge, decision-making tool to help clinicians and patients select the best lung cancer treatment based on each patient’s specific needs and circumstances.

Article • Don't miss:

Talks and panel discussion at the Labmed forum

At this year's Medica tradefair, laboratory medicine, medical technology and life sciences give new impulses to the entire healthcare market - especially in times of the corona pandemic. An overview.

Article • Brain imaging

White matter hyperintensities: a valuable biomarker to assess mortality risk

White matter hyperintensities (WMH) on the brain seen on MRI represent a biomarker associated with a 50/50 risk of death within five years after a first incident acute ischemic stroke (AIS) or transient ischemic attack (TIA).

Advanced staining can be beautifully simple when we standardise it

Imagine, one single standardising solution, enabling uncompromisingly fast results and providing you with the exact same predictable turnaround time.

Article • Detecting several different diseases

Multiplex diagnostics: next-generation techniques for new challenges

With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.

Article • Imaging advances

Liver disease assessment: AI may give CT the edge over MRI

To assess diffuse liver disease, MRI is currently the modality of choice. New developments in artificial intelligence (AI) could tip the scales in favour of CT imaging. At ECR 2022 in July, experts showed how AI technology enables CT to quantify liver fat as exquisitely as MRI.

CNN applications in pathology

‘Deep learning can predict survival directly from histology in clear cell renal cell carcinoma’

Renal cell carcinoma is among the fifteen most common cancers worldwide. Dr Titus Brinker, from the German Cancer Research Center (DKFZ), looked at whether a convolutional neural network (CNN) can extract relevant image features from a typical H&E-stained slide to predict 5-year overall survival.

Article • AI provides prognostic information

Next-generation deep learning models predict cancer survival

Deaths from cancer are currently estimated at 10 million each year worldwide. Conventional cancer staging systems aim to categorize patients into different groups with distinct outcomes. ‘However, even within a specific stage, there is often substantial variation in patient outcomes,’ Markus Plass, academic researcher from the Medical University of Graz, Austria, explained to Healthcare in…

Article • Patient care

Molecular Tumour Board for better decision-making

As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.

News • Biomarker research

Alzheimer's: blood test detects beta-amyloid

Researchers from Japan have developed a method to detect build-up of amyloid β in the brain, a characteristic of Alzheimer’s disease, from biomarkers in blood samples.

News • Hopeful study

A noninvasive way to diagnose endometriosis

Women can suffer for years with the debilitating pain and medical complications of endometriosis without a diagnosis. Now, researchers believe they may be able to diagnose the condition using just menstrual blood.

News • Lung adenocarcinoma

Therapeutic target against common lung cancer identified

A new study led by researchers in Barcelona has determined the protein TIMP-1 as a valuable biomarker for the progression of lung adenocarcinoma. The results open the door to new treatments.

Article • Interpreter of maladies

Will AI help realize the promise of precision medicine?

Machine learning and artificial intelligence (AI) have the potential to transform cancer treatment management worldwide. Their ability to rapidly analyse and integrate routinely acquired diverse data will improve the accuracy and effectiveness of precision medical treatments.

News • Biotechnology

Miniature biosensor monitors condition of serious wounds

Researchers at Nottingham Trent University and Nottingham University Hospitals NHS Trust have developed a new biosensor capable of accurately monitoring the condition of a chronic wound.

Advanced staining – Getting the optimal slide

Advanced staining evolved with growing complexity, resulting in many variations and combinations to get the right staining quality. It felt the flexibility brings you total control, but actually what we see is the introduction of multiple variables. This endless tweaking has taken its toll.

News • Precision oncology

What's new in cancer therapy?

Researchers from the University of Bern and Inselspital provide an overview of the latest technologies in precision oncology. Translating these into clinical application is still a major challenge.

Article • Overheard at AACC

The complexities of drug testing in urine and hair

Urine screening tests using only immunoassays are the most common procedures used to identify drug abuse. They are inexpensive, automated, and produce rapid results. But they may generate false-positive or false-negative results, which vary based on the drug, drug class, and the assay used. Hair toxicology analysis is another form of drug testing which, unlike urine tests, enable analysis of drug…

News • In-depth view at neurodegeneration

New 3D imaging approach looks into earliest stages of Alzheimer's

Novel 3D imaging could comprehensively characterize a part of the brain that shows perhaps the earliest accumulation of tau protein, an important biomarker for the development of Alzheimer's disease.

News • Support for seniors

Sensor-based early detection of age-related diseases from home

Swiss researchers have demonstrated how sensors could help detect health problems in the elderly at an early stage. This could help seniors to live a self-determined life at home for longer.

Article • Heart failure with preserved ejection fraction

HFpEF poses increasing burden on health services

With the life expectancy of populations improving, experts believe the rising diagnosis and prevalence of patients with heart failure with preserved ejection fraction (HFpEF) will have a significant impact on healthcare services going forward.

News • Spit take

Portable diagnostic detects SARS-CoV-2 RNA and antibodies

The prototype device combines eRapid and SHERLOCK technologies into a single, postcard-sized system that can simultaneously detect the presence of both SARS-CoV-2 RNA and antibodies in a patient’s saliva.

News • Cardiomyopathy research

Genetic defects can cause heart failure

Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports.

News • Liquid biopsy for early detection of brain tumours

Glioblastoma: Mathematical modelling could lead to simple blood test

The development of a simple blood test for glioblastomas could mean earlier diagnosis and more effective and personalised treatment options against the most common type of malignant brain cancer.

Article • Imaging biomarkers, AI support and beyond

New tools for Covid-19 assessment

As knowledge about Covid-19 advances, so does the arsenal of techniques to predict, diagnose and follow up on the disease. At ECR, researchers presented a range of promising imaging modalities to keep track of Covid-19 symptoms, severity, and mortality, often including AI support to enhance or accelerate diagnostics.

News • Early dementia detection

Protein sensor detects Alzheimer's up to 17 years in advance

A sensor identifies misfolded protein biomarkers in the blood. This offers a chance to detect Alzheimer's disease before any symptoms occur. Researchers intend to bring it to market maturity.

Article • MEDIRAD project

Increasing the protection from medical radiation

A Europe-wide project aims to improve medical radiation protection for patients and staff by better understanding and evaluating the health effects of exposure to low-dose ionising radiation resulting from diagnostic and therapeutic procedures.

News • Determining aggressiveness

New discovery improves prostate cancer prognosis

Researchers in Sweden have now discovered a faster and easier way to determine who has an aggressive form of prostate cancer, and who has not.

News • As good as gold

Raman spectroscopy: a wearable chemical sensor

Researchers created a special ultrathin sensor, spun from gold, that can be attached directly to the skin without irritation or discomfort. The sensor can measure different biomarkers or substances to perform on-body chemical analysis.

Article • Current and emerging imaging applications

Challenges of AI in chest radiography

Physicians use AI-powered technology for faster and earlier detection of diseases. At ECR Overture, Dr Steven Schalekamp, PhD, discussed the application of AI for chest radiography in paediatrics.

News • Radiophysiomics

Diagnosing brain tumors using machine learning

The classification of brain tumors—and thus the choice of optimal treatment options—can become more accurate and precise through the use of artificial intelligence in combination with physiological imaging.

News • Vortex fluidic device

Next step in rapid diagnostics for infectious diseases

The speedy, high-tech method of inexpensive, accurate and high-throughput protein biomarker assay testing is being touted as a much-needed development in point-of-care (PoC) testing.

News • Unifying disease dynamics

Covid-19: New insights into recovery after severe disease

Recovery from severe Covid-19 is characterized by a reduction of certain white blood cells and changes in the molecular regulation of the immune system, an international research team found.

News • Biomarker from blood test

Lung cancer: Liquid biopsy accurately predicts immunotherapy response

A simple blood test could be a better predictor of whether cancer immunotherapy will be successful for a patient with lung cancer than an invasive tumor biopsy procedure.

News • In vivo

Magnetic resonance imaging shows brain inflammation

Researchers visualize brain inflammation using diffusion-weighted MRI. This detailed "X-ray" of inflammation cannot be obtained with conventional MRI, but requires data acquisition sequences and special mathematical models.

News • Oncology

A new biomarker for personalized breast cancer therapy

"Crown-like structures" surrounding breast tumors in overweight and obese patients could hinder their response to therapy. The findings of this study could potentially be used to improve personalized treatment for patients.

Article • Glioblastoma analysis

Revealing tell-tale signs of deadly brain cancer

A new way of differentiating healthy from diseased cells could pave the way for more personalised treatment for patients diagnosed with glioblastoma multiforme (GBM), a common and aggressive type of brain tumour.

Article • Detection and diagnosis of cancer

The ‘smart’ future of cytology

A combination of digital pathology and quantitative biomarker analysis in the emerging concept of ‘smart’ cytology has a potential role in the detection and diagnosis of cancer.

News • Multi-tasking

Wearable monitors glucose, alcohol, and lactate

Engineers have developed a prototype of a wearable that can continuously monitor several health stats—glucose, alcohol, and lactate levels—simultaneously in real-time.

News • mhealth

Smartphone-powered microchip for at-home diagnostic testing

Researchers developed a new microfluidic chip with broad applications for detecting viruses, pathogens, bacteria and other biomarkers in liquid samples.

Article • Clinical computational tools

Managing cancer more effectively

Computational approaches are being applied on enormous amounts of data from sequencing technologies to develop tools to help clinicians manage cancer more effectively.

Article • Patient Reported Outcomes

Going “PRO” to advance cancer treatment

Involving cancer patients more closely in the treatment pathway can modify care and deliver better outcomes. Carefully designed questionnaires and treatment response monitoring are helping clinicians take therapies to a new level.

News • Measuring gases released from skin

Future wearables could open new way to monitor metabolic diseases

Scientists have taken the first step to creating the next generation of wearable health monitors, which could monitor the body’s health by detecting the gases released from a person’s skin.

News • Viral aftereffects

Long Covid: Six in ten have at least one symptom one year after infection

Six in ten people with Covid-19 still have at least one symptom a year later, a new study has found. Furthermore, symptoms that don’t clear up after 15 weeks are likely to last at least a year.

News • Neuroimaging

A clearer picture of Multiple Sclerosis

Cedars-Sinai physician-scientists are pioneering imaging techniques and investigating new biomarkers to improve multiple sclerosis (MS) diagnosis and treatment.

News • Identification in comatose patients

Electrochemical waves as early warning marker for stroke

Researchers from Charité – Universitätsmedizin Berlin have shown that massive electrochemical waves in the brain act as a marker announcing an impending ischemic stroke.

Article • Standardisation in drug monitoring

How traceability eliminates lab-to-lab variability

The advantages and limitations of the value of traceability chains in therapeutic drug monitoring will be explored during a key session at the EuroMedLab event.

Article • AI and DL to drive precision medicine

Diving into medical big data

Big data is transforming diagnosis and medical care, but the critical challenge remains over how to equally apply the benefits it delivers across real-world clinical settings, according to industry expert Prof Benoît Macq.

News • Metastasis research

How tumour cells ‘camouflage’ to avoid detection in the bloodstream

New insights in the metastasis process: tumour cells pass themselves off as platelets to go undetected in the bloodstream, researchers from Granada have discovered.

New sepsis marker speeds up detection and therapy

Sepsis is the cause of one in five deaths worldwide, killing nearly 11 million people each year, many of them children. It is also a major cause of disability, affecting millions more. To combat the condition, many hospitals have implemented sepsis performance improvement programmes. A meta-analysis of 50 observational studies showed that these programmes are associated with better compliance…