Klebsiella is among the top three pathogens responsible for hospital-acquired infections (HAIs). Now, researchers discovered why the bacteria thrive in clinical environments.
Using genomic sequencing data, researchers have created personalised simulations of individual patients that can quantify the impact of genetic mutations on cancer cell behaviour.
Staphylococcus aureus is a leading cause of hospital-acquired bacterial infection, associated with over one million deaths worldwide each year. Now, researchers could be one step closer to a vaccine.
A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.
Why does the immune system sometimes fail to control the development of bowel cancer? UK and Dutch researchers discovered how cancer cells use a genetic "switch" to evade detection.
How do pathogenic bacteria evolve to become epidemic? To find out, researchers examined DNA data from almost 10,000 samples taken from infected individuals, animals, and environments around the world.
Researchers at Stanford have demonstrated that conditions in the matrix surrounding pancreatic cancer cells impact whether those cells respond to chemotherapy.
Integrating bacterial genomic data with detailed human mobility data makes it possible to see how pathogens causing pneumonia and meningitis, move between regions and evolve over time.
Finnish researchers discovered a mechanism that wakes up dormant breast cancer cells and demonstrated that preventing the mechanism can significantly improve treatment outcomes in experimental models.
Pancreatic cancer stem cells exploit an antibacterial protein to evade the immune system. Removing this protein could pave the way to more effective immunotherapy, new research suggests.
A research group established a microfluidic control technology that can be applied to small blood testing devices and consequently developed a novel integrated immunoassay device.
Tissue biopsy and liquid biopsy can increasingly be used as complementary or alternative approaches, with advantages and limitations to each. While speakers at the recent 35th European Congress of Pathology in Dublin were quick to highlight that liquid biopsy was not about to replace tissue biopsy, the focus looked at the benefits and challenges of each through the lens of four expert speakers.
A new study explores the phenomenon of heteroresistance in bacteria, which is a key driver of antibiotic resistance. Two new discoveries could impact the development of future AMR strategies.
Delegates from Hannover Medical School and the University of Glasgow have now signed a letter of intent to intensify their collaboration in the field of infection research.
Researchers have succeeded in developing “pathoblockers” that provide protection against the most common pneumonia-inducing pathogens, even if they are resistant to antibiotics.
The rate of sepsis in newborns across Sweden has greatly decreased – however, the use of antibiotics for sepsis prevention has not. A new study points out the extent of the overuse.
Could the 'gene scissors' CRISPR be used to make resistant bacteria susceptible to first-line antibiotics again? According to new reseach, yes – but the experts also point out serious caveats.
Antimicrobial-resistant infections have become a global threat, with an annual death toll of over 1 million. Now, reseachers created a promising vaccine candidate for antibiotic-resistant bacteria.
Coronary artery disease causes more than 1.8 million heart attacks each year in Europe. In most cases, rehabilitation helps the patients to return to their everyday life. But what happens once the patients have left the rehab clinic?
A new SPECT/CT imaging technique using lead-212 (²¹²Pb) shows promise in targeted alpha therapy (TAT) for patients with metastatic castration-resistant prostate cancer.
A new study identifies hospital sinks as a source of bacterial outbreaks, highlighting the vulnerability for contamination. The researchers also point out the difficulties in stopping such outbreaks.
Catheter ablation of atrial fibrillation is an important treatment option for heart rhythm maintenance and symptom reduction. Now, an international consensus statement reflects new techniques.
Researchers are developing novel active substances designed to cut off the nutrient supply of resistant bacteria, effectively starving them to death.
A new detection tool is designed to contribute to improving tumour research and classification by identification and quantification of chromosomal instability in the nuclei of cancer cells.
A person’s age, sex and location are correlated with the chance that they have a bloodstream infection that is resistant to antibiotics, according to a new study.
Why are we doing what we are doing to stop surgical infections? A new research review in the run-up to the ECCMID congress 2024 will look at improving preventive measures.
A new way to analyze blood samples for suspected sepsis gives doctors test results two days earlier than before – a head start that could mean life or death for patients.
Research reveals how a new mechanism could improve the efficiency of current treatments for diabetes. This may open up new ways of approaching metabolic diseases that are a global health problem.
Under certain circumstances, lung tumours can transform into another, more aggressive cancer type. Now, researchers have found a way to illuminate this process, known as histological transformation.
Targeting a specific protein, Finnish researchers may have found a way to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment.
Once a patient’s body has been colonized by resistant bacteria, they can persist for a long time, a new study by the University and University Hospital of Basel shows.
Researchers in Japan and the US have developed technology to robustly augment the amount of MHC class I molecules in cancer cells. This makes them easier to find and destroy for the immune system.
Using a unique new technique, US researchers hope to offer a safer and more effective alternative to current cancer treatments, reporting promising first results in mice.
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Researchers have analysed the rise of antibiotic resistance over the last 20 years in the UK and Norway, highlighting that antibiotic use is not the only factor in the increase.
A new synthetic antibiotic developed by University of Liverpool researchers is shown to be more effective than established drugs against ‘superbugs’ such as MRSA, a new study shows.
Given the limited success of traditional therapies for depression, recent years have witnessed the emergence of technology-based interventions. One such intervention is transcranial electromagnetic stimulation (TMS).
A low-cost technology involving nano-sized antimicrobial compounds against tuberculosis has been developed by researchers at São Paulo State University (UNESP).
Using diffusion MRI technology, researchers in Sweden have found differences in brain tissue structure between patients with persisting symptoms after Covid-19 and healthy people.
US researchers discuss three blood-based liquid biopsies, namely circulating tumor cells, circulating tumor DNA and tumor-derived exosomes, as they relate to prostate cancer management.
Scientists map the effects of 86 immune-signaling molecules called cytokines on every major immune cell type, creating a reference for studying the inner workings of the immune system.
Assays: Clozapine, Risperidone, Aripiprazole, Olanzapine, Quetiapine, Paliperidone Highlights:Antipsychotic drug monitoring provides healthcare professionals accurate and vital information.Testing of antipsychotic drugs can help manage patient therapy by providing greater clarity on the causes of treatment failure (i.e., adherence, drug resistance, drug-drug interactions and drug…
In a new study, UCLA researchers demonstrated how small cell neuroendocrine prostate cancer tumor cells can arise from less aggressive prostate tumors.
A new deep-learning approach to AMR testing has been shown to detect antimicrobial susceptibility within as little as 30 minutes - significantly faster than current gold-standard approaches.
Cedars-Sinai Medical Center, a non-profit hospital and medical research institution in Los Angeles, is setting new standards for quality and innovation in patient care by successfully introducing typing of Candida auris species – a procedure that could prove crucial in protecting patients from infection outbreaks caused by these microbes in healthcare settings.
Pancreatic cancer is not just one disease, but that’s the way it is currently treated. New work from Columbia University could help pave the way for a change.
A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.
A new study on public health communication shows that the term commonly used to describe bacteria resistant to current medicines or antibiotics fails to stick in people’s memories.
The enhanced infection safety measures installed for the Covid-19 pandemic also had a beneficial effect on hospital-acquired infections (HAIs) overall, a new US study suggests.
A team of researchers from Vienna has discovered that dormant breast cancer tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein.
Using placebos in primary care to reduce overprescribing, conserve existing antibiotics and limit further resistance, is publicly acceptable, a new study shows.
After pelvic radiotherapy, patients may live with low-grade chronic inflammation of the lower intestine 20 years after the treatment, a new study shows.
Being able to rely on a quality, safety-engineered device for blood collection allows staff to perform their tasks with the minimum of fuss. Nurse Constance Mak talks about the benefits of closed collection systems.
Researchers at the University of Michigan have zeroed in on Candida auris – a fungus with the uncanny ability to stick to everything from skin to catheters – and made a startling discovery.
US researchers have discovered that radiation therapy combined with two types of immunotherapy can control tumors in preclinical models of triple negative breast cancer.
A new class of antibiotics, based on proven drugs used in cancer treatment, is now being developed by researchers at Linköping University. They could be used against resistant bacteria.
From cancer to AI, from management to new medication: this year's Labmed Forum at MEDICA 2023 in Düsseldorf (November 13-16) once again features an exciting scientific programme.
A new research breakthrough could lead to the development of new treatments for people with compromised immune systems, such as those with cystic fibrosis.
New research from Lund University has found a suprisingly high incidence of sepsis across hospital admissions. The experts say that the condition can be likened to an epidemic.
Can per- and polyfluoroalkyl substances (PFAS) increase the risk of breast cancer? A new study by US researchers examines the effects of the so-called “forever chemicals”.
Brain tumour progression to a malignant state is believed to be the result of an intricate interplay between cancer cells and the tumour microenvironment. Greek researchers shed new light on the mechanisms.
Curbing levels of harmful air pollution could help reduce antibiotic resistance, according to the first in-depth global analysis of possible links between the two.
German bioinformaticians have now detected an unexpected diversity of certain cell appendages in the bacterium Acinetobacter baumannii that are associated with its pathogenicity.
A new AI model finds that x-ray images collected during routine medical care can provide warning signs for diabetes, even in patients who don’t meet the guidelines for elevated risk.
A new study led by researchers from the University of Notre Dame links a high body mass index (BMI) to alterations in the structure and environment of cancerous tumors.
AI, robotics, climate change and more: Swedish researchers outline emerging technologies and trends that may define what the healthcare industry looks like in the next 50 years.
A gel that combines both stiffness and toughness is a step forward in the bid to create biodegradable implants for joint injuries, according to new research from the University of British Columbia.
Gentle cleansers are just as effective in killing viruses – including coronavirus – as harsh soaps, according to a new study from scientists at the University of Sheffield.
US researchers identified a potential breakthrough in glioblastoma treatment. Using a modified virus, they created a treatment that specifically attacks tumor cells, while leaving normal cells intact.
Knots are a crucial part of surgery, but surprisingly little is known about how they work. To fill this gap, a team at EPFL started the first physics-based study on the mechanics of surgical knots, and exactly what properties influence their strength.
Governments around the world must do more to tackle the growing threat of drug-resistant infections, new research led by the University of Leeds suggests.
AI could find critical biomarkers that predict non-response to conventional treatment in patients with chronic myeloid leukaemia (CML) more quickly, researchers in Singapore find.
Researchers at Karolinska Institutet have developed a molecular method able to detect whether or not bacteria respond to antibiotics within minutes.
A University of Arizona Health Sciences-led study found that more than 50% of people don't fully trust AI-powered medical advice, but many put faith in AI if it's monitored and guided by human touch.
A team at the Finnish research institute VTT has created a biodegradable ECG patch, aiming to pave the way to a more sustainable future for wearable electronic devices.
Tumors sometimes seem to take on a life of their own, with cancer genes “striking out” in ring shapes. An international research team has new insights into this phenomenon.
Newly developed “smart” coatings for surgical orthopedic implants can monitor strain on the devices to provide early warning of implant failures while killing infection-causing bacteria.
A group of researchers has illustrated the mechanistic pathway for PTEN-deficient breast cancer and successfully tested a method of countering the downstream effects of immune system evasion by tumors.
Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the chemotherapy of testicular cancer.
Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient's metastatic prostate cancer.
When in doubt, write a prescription? New research links burnout in GPs to higher antibiotic and strong opioid prescribing, especially in more deprived areas of the North of England.
Chemotherapy resistance is a main cause of treatment failure and death in cancer patients. Researchers from Brussels found how cancer cells protect themselves from the aggressive treatment.
An international study has shown how a decision tool for health professionals has proved capable of halving the use of antibiotics against urinary tract infections while maintaining patient safety.
Imaging researchers have taken a major step towards their ultimate goal of identifying cancers that are starved of oxygen so that altered treatment can be used to target them more effectively.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Cancer cells have an innate randomness in their ability to respond to chemotherapy, which is another tool in their arsenal of resisting treatment, new research shows.
Scientists from Japan demonstrated, for the first time, a successful chemogenetic suppression of widespread epileptic seizures in macaque monkeys. Their findings represent an essential step towards clinical trials, and effective treatment for patients with severe epilepsy.
Arthroplasty for femoral neck fractures has seen enormous progress in recent years, but complications due to infections are still a major problem. With good preparation and the right technique, however, orthopaedic surgeons can take away much of the horror of this scenario.
Researchers from the University of Liverpool have tested whether the AI-powered chatbot ChatGPT could be used to make decisions about prescribing patients with antibiotics.
The newly founded UK Focused Ultrasound Foundation is dedicated to advancing the development and adoption of the technology, which can be used to non-invasively treat tissue deep in the body.
Carriers of a specific bacteria have a 14% chance of developing an antibiotic resistant infection with 30 days of hospitalisation, according to new research from Amsterdam.
A Korean research team successfully changed the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.
Focused ultrasound (FUS) ablation is an emerging treatment for breast tumours. Its use was highlighted in an October webinar focused on emerging immunotherapy research and breast cancer.
Some hospitalized patients’ infections may develop from their own bacteria, new research results suggest. The study in mice indicates that medical interventions can awaken dormant, hidden bacteria.
A rare variant of a protein present in nearly all human cells may hold the key to improving the effectiveness of breast cancer treatment, according to University of Manchester research.
Swedish researchers have developed a method that should be able to predict whether a patient with breast cancer will benefit from a particular treatment or not.
Both hot and cold environments trigger a stress response and can lead to cardiovascular problems. Results of a new study are especially interesting in light of the current multiple global crises.
Researchers have designed and synthesized analogs of a new antibiotic that is effective against multidrug-resistant bacteria, opening a new front in the fight against these infections.
Scientists managed to identify and kill breast cancer cells that evade standard treatments in a study in mice. The is a step towards the development of new treatments to prevent relapse in patients.
Glioblastomas march to the beat of a different drum: researchers discovered a type of cells that act as pacemakers, driving the growth of the brain tumour and increasing its resistance.
An international research team has provided valuable new information about what drives the global spread of genes responsible for antimicrobial resistance (AMR) in bacteria.
A pioneering ‘smart contact lens’ to test the eye in a quick, non-invasive way could prevent deaths caused by fungal eye infections in developing countries.
Eunsin Bae, M.D. specializes in laboratory medicine and leads the Institute of Clinical Research at Seegene Inc. Her research focuses on microbiology, molecular biology, and hematology. Dr. Bae is currently working toward implementing a global clinical study and establishing an international network of clinical investigations.
Innovative gastrointestinal imaging, medical panel PCs with hygiene optimisation, smartphone-based diagnostic tools, and sustainable hardware setups: At Medica 2022, manufacturers from Taiwan again showed their capability to adapt and provide solutions for a world radically changed by the Covid-19 pandemic. Under the “Taiwan Excellence” banner, outstanding products from the island nation’s…
A new Oxford University study provides the first direct evidence of antibiotic resistant bacteria migrating from a patient’s gut microbiome to the lungs, increasing the risk of deadly infections.
Periprosthetic infections and revisions are on the rise in Germany and worldwide, with significant consequences for affected patients as well as for the healthcare systems. Precisely because the number of patients at higher risk of infection in arthroplasty continues to rise, attention is increasingly focused on how this dreaded complication can be avoided.
It is the size of a common pencil eraser, but it could have a huge impact on the therapy of glioblastoma: Scientists in Virginia have developed a novel 3D tissue-engineered model of the brain tumour microenvironment, which can be used to assess how the glioma cell invades healthy tissue, proliferates, and reacts to chemotherapy drugs.
Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease.
Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models.
Nowadays, the operating theatre is networked and staff have access to a wide range of information and image data. With the Clinio, Rein Medical offers a medical all-in-one (AIO) computer that has been designed for use in hygienically sensitive areas.
With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.
Colorectal cancer is one of the most common cancers. A team from the University of Geneva has found an alternative for patients who have developed resistance to chemotherapy treatments.
Engineers from EPFL and the University of Strasbourg have developed a surgical needle whose trajectory can be corrected on the fly, thanks to a flexible tip controlled with a simple button.
As more genomic alterations become targets for therapy, health institutions and hospitals are creating specialist Molecular Tumour Boards to support better decision-making for patient care. This evolving team, and its role, was highlighted in a presentation at the 34th European Congress of Pathology in Basel, Switzerland.
Not just uncomfortable, but hard on the heart: Accumulating research suggests a link between hot flashes during the menopause and cardiovascular disease risk in women.
Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.
Antibiotic prescribing in primary care could be monitored using health insurance data. And reduced with a simple test.
Cambridge scientists have discovered that cancer cells ‘hijack’ a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.
The oncogene EVI1 causes an aggressive type of leukemia, but its exact function has been a mystery. A research team now showed that EVI1's cancer causing effect relies on activating a single gene — the stem cell transcription factor ERG.
What will the next pandemic look like? Health officials from across the globe gathered in Geneva in late August at a World Health Organization meeting to focus on how lessons learned from Covid-19 might best prepare civilization for the "next one."
Alveolar rhabdomyosarcoma is a rare pediatric tumor. For more than 40 years there has not been any new development regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now identified a new therapeutic option, using a drug that is currently under investigation for other types of cancer.
UC San Francisco researchers have developed a drug marking cancer cells for destruction by the immune system.
A new study could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis, are resistant to antibiotics.
German researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases such as Alzheimer's.
Researchers discovered that cancer cells mobilize a SOS response when they are desperate to resist anticancer drugs. The team also came up with an anti-SOS approach that blocked the mechanism in mice.
The new washer-disinfector series exhibits comprehensive decontamination and disinfection performance against all human-pathogenic viruses, confirms accredited testing laboratory HygCen Germany GmbH.
A surprising mechanism explains why high-grade gliomas, the deadliest form of brain cancer, returns: The tumours adapt to treatment by recruiting help from nearby healthy tissue.
A research team has created the first gel-based cartilage substitute that is even stronger and more durable than the real thing, offering a promising solution for patient suffering from knee pain.
Researchers at McMaster University create device to replicate conditions in blood vessels after grafts.
A comprehensive assessment of scientific literature has uncovered empirical evidence that more than 58% of human diseases caused by pathogens, such as dengue, hepatitis, pneumonia, malaria, Zika, have been aggravated by climatic hazards.
A project to develop advanced sensors for use in robotic systems could transform prosthetics and robotic limbs. It aims to develop sensors which provide enhanced capabilities to robot.
Avian flu, MERS, Covid-19, monkeypox: outbreaks of infectious diseases are getting more common in Europe. As a result, the EU must adapt its surveillance strategies and introduce more data-driven, interdisciplinary countermeasues.
Hospital patients who develop infections where 10% of sufferers die will be offered double the traditional course of antibiotics in a new trial.
Researchers propose a new Covid-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies - a promising alternative for people with a weakened immune system.
Indwelling catheters through the urethra often cause bacterial infections. A newly discovered synthetic peptide is a promising treatment option, even against antibiotic-resistant pathogens.
A sprayable coating that can prevent the surface spread of infection from bacteria and viruses – including Covid-19 – over a sustained period has been developed by Australian researchers.
Cancer immunotherapy is a successful treatment form in oncology, but it doesn't work for every patient. One problem may be the lack of a specific type of immune cell in the tumor, researchers found.
The Covid-19 pandemic has highlighted the importance of the fast and accurate diagnosis of infectious diseases in clinical settings. Harald Maier discusses the implementation of rapid molecular diagnostics in the central clinical diagnostics laboratory at Innklinikum Altötting and Mühldorf, highlighting how the use of PCR testing has benefitted the hospital during the Covid-19 pandemic.
Building artificial intelligence (AI) tools that clinicians and patients can trust, and easily use and understand, are core to the technology being successfully deployed in healthcare settings.
MIT researchers produced textiles that sense the wearer’s posture and motions. Their “smart” shoes and mats could be used in applications ranging from health care to prosthetics.
A Stanford mechanical engineer creates multifunctional wireless robots to maximize health outcomes and minimize invasiveness of procedures.
Over the last 50 years, malaria parasites have developed resistance to seven drugs, but a new way to identify future antimalarials holds promise.
Latest developments in computational protein design enable the simulation of sequence and structural changes in proteins for creating novel agents in human medicine.
Hospital-acquired infections are dangerous for patients and costly for clinics. A novel surface treatment could help improve the safety of medical devices and ease the economic burden.
Glucose is absorbed from the foods we eat and fuels every cell in our bodies. But could it also power tomorrow’s medical implants? According to a team of engineers, it might.
Bacteriophages – viruses that kill bacteria – could be a solution for fighting antibiotic-resistant pathogens, French researchers have developed a model to better predict their efficacy.
A new way of differentiating healthy from diseased cells could pave the way for more personalised treatment for patients diagnosed with glioblastoma multiforme (GBM), a common and aggressive type of brain tumour.
SARS-CoV-2 depends on the broadly antiviral interferon-induced human transmembrane proteins , to enter human cells and replicate inside them.
The search for rare mutations in bacterial genome could lead to better diagnostics and treatments – reducing morbidity caused by the deadly disease.
Scientists have created a design and fabrication tool for soft pneumatic actuators for integrated sensing, which can power personalized health care.
Microfluidic chip inflates and deflates balloons in a sleeve to promote fluid flow in the lymphatic system.
A team of researchers from Singapore has developed a novel magnetic therapy that serves as an effective companion therapy to chemotherapy to enhance treatment outcome for breast cancer.
Mental disorders are among the leading causes of ill-health and disability worldwide, and the demand for a viable solution to battle the mental health crisis has risen. The past two decades have witnessed the emergence of extended reality (XR) as a tool for investigation, assessment, and management in mental healthcare.
Climate change and antimicrobial resistance (AMR) are forming an alarming alliance: Global warming creates new breeding grounds for resistant bacteria. A serious and very real threat to public health – but not quite the doomsday scenario some might make it out to be, says Prof Sabiha Essack from the University of KwaZulu-Natal in Durban, South Africa.
Finding the right antibiotic dose is akin to a Goldilocks problem: give too little, and the infection will persist; too much, and side-effects will override the benefits of the therapy. To get it “just right”, Prof Dr Birgit Koch talks about dosing optimisation in the clinical setting.
Accurate home testing could be used for a wider range of illnesses, as new research shows the capability of smartphone-powered tests for Dengue Fever.
When treating acute infections, health care providers must quickly identify the best antibiotics for fighting the infection. An automated system provides swift, accurate results for determining the best antibiotics at the right dose.
Researchers are developing wearable devices to catch early signs and symptoms of diseases or monitor sick patients. We spoke to wearables and medical device expert Professor John Rogers about the benefits, challenges, trends and innovation within the sector.
In the human intestine, Escherichia coli is mostly harmless, but in certain conditions causes bladder infections and even sepsis - but why? Researchers went to the bottom of this transformation.
Modern medicine offers “peel and stick” solutions like nicotine or contraceptive patches to put right on the skin without needing to visit a doctor for an injection or procedure. Now, researchers have found that applying a topical ointment containing anti-tumor factor can increase the effectiveness of cancer treatment.
Scientists from Hokkaido University have identified new targets for treating Adult T-cell leukemia/lymphoma (ATLL), an aggressive form of blood cancer with existing drugs.
Sepsis is the cause of one in five deaths worldwide, killing nearly 11 million people each year, many of them children. It is also a major cause of disability, affecting millions more. To combat the condition, many hospitals have implemented sepsis performance improvement programmes. A meta-analysis of 50 observational studies showed that these programmes are associated with better compliance…
Researchers find that drug-resistant bacteria can be distinguished from non-resistant bacteria based on structural changes evident in electron microscope images with high accuracy using deep learning.
Liquid profiling is offering clear benefits in terms of cancer diagnostics and targeted therapy, but challenges remain in bringing it into the clinic.
Model tumour systems could help explain whether pressure differences can push cancer cells into their surroundings – a basic mechanism behind metastasis.
Researchers have succeeded in using metal oxide nanoparticles as "radiosensitizers" – and in producing them on an industrial scale.
An international team of scientists have shown that small and large bacterial populations follow qualitatively different evolutionary paths to develop antibiotic resistance.
A newly discovered structure of chain-mail may explain the success of C.difficile at defending itself against antibiotics and immune system molecules.
A new kind of bone implant reduces the chance of infection, and therefore significantly decreases implant failure rates.
Mathematical models used as patient surrogates could help clinicians select the best cancer treatment before going to the patient’s bedside.
Researchers have developed an inexpensive, non-toxic coating for almost any fabric that decreases the infectivity of the virus that causes COVID-19 by up to 90 per cent.
Researchers have identified a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome.
Researchers have developed a new type of lightweight 3D-printed back brace capable of sensing how effectively it fits patients. Its developers say it could lead to improved treatment for scoliosis.
Researchers from Auckland have uncovered a link between the sharpness of surgical tools such as scalpels and the risk of post-surgery infection.
Scientists have investigated the effectiveness of various common hand disinfectants against hepatitis E. They were able to show that most formulations do not completely inactivate the virus.
Scientists at Queen’s University Belfast have invented a tiny indicator that changes colour if a patient’s wound shows early signs of infection.
Esslingen is one of the most innovative regions worldwide. Thus, it does not come as a surprise that Esslingen‘s 660-bed hospital is interested in adopting cutting-edge technology. A surgical robot, to be precise.
Researchers used artificial intelligence to identify sets of genes that predict whether a patient will acquire severe sepsis.
A type of the antibiotic resistant superbug MRSA arose in nature long before the use of antibiotics in humans and livestock, which has traditionally been blamed for its emergence.
The long-term impact of the coronavirus pandemic on antimicrobial resistance remains difficult to predict. Infectious diseases consultant Professor Alison Holmes reflects on Covid-19's effect on antibiotic use in hospitals and beyond.
For many years, antibiotic consumption in France was at an alarming level, resulting in a worryingly constant increase in antibiotic resistance However, a newly-enforced strict national plan appears to be having effect.
Evonik offers a comprehensive portfolio of 3D printable med-tech biomaterials that can be used to produce medical devices with temporary or permanent body contact. Marc Knebel, head of Medical Systems at Evonik, explains the benefits and applications of the new high-performance polymer VESTAKEEP Care M40 3DF.
Mark Nicholls reports from the National Cancer Research Institute (NCRI) virtual Festival, with four expert speakers discussing the role of liquid biopsy in cancer detection.
A worldwide consortium aims to equip researchers in low- and middle-income countries (LMICs) with cheap and accessible methods for sequencing large collections of bacterial pathogens.
To counteract the spread of resistant germs, researchers have developed new drug candidates that are able to render one of the most important hospital germs harmless.
One size does not fit all when it comes to diagnostics. Different diagnostic locations need solutions that meet their needs, whether for on-demand testing in a healthcare setting or a laboratory managing population screening. Finding the right solution can be a challenge especially when the future may change what a laboratory needs, Hologic Inc. reports.
The Zybio EXS2600 mass spectrometry system enables rapid microbial identification, including bacteria and fungi. With an advanced pre-filled sample kit, user-friendly software and a comprehensive strain database, the EXS2600 offers high-throughput screening, convenient operation and accurate results.
Researchers at the University of Rochester, and Delft University of Technology in the Netherlands recently developed a 3D printing technique to engineer and study biofilms—three-dimensional communities of microorganisms, such as bacteria, that adhere to surfaces. The research provides important information for creating synthetic materials and in developing drugs to fight the negative effects of…
According to scientists at Rice University’s George R. Brown School of Engineering, discarded polystyrene broken down into microplastics provides a cozy home not only for microbes and chemical contaminants but also for the free-floating genetic materials that deliver to bacteria the gift of resistance.
Heart failure with preserved ejection fraction was previously considered largely untreatable. A research team at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) led by Professor Michael Gotthardt has now succeeded for the first time in improving cardiac function with the help of a synthetic nucleic acid, as the researchers report in the journal Science…
In multiple myeloma, a cancer of the bone marrow, relapse almost always occurs after treatment. Initially, most patients respond well to therapy. However, as the disease progresses, resistant cancer cells spread in the bone marrow, with fatal consequences for the patients. Scientists at the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and the National Center for…
A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.
Experts predict that without intervention, the problem of multidrug-resistant bacterial infections could be catastrophic by 2050, killing nearly 10 million people each year.
Researchers have found that regular blood tests can help detect whether prostate cancer patients have resistance to drugs treating the condition. The findings were presented at the National Cancer Research Institute (NCRI) virtual Festival.
Professor Dina Tiniakos, from the National and Kapodistrian University of Athens, predicts that NASH (Non-alcohol related steatohepatitis) cases will soar worldwide by 2030, with 800,000 liver deaths, costing health economies billions of dollars.
For nuclear medicine specialists, 2021 may be heralded as a banner year validating the use of theranostic technology to treat cancer. Long-awaited results from the international phase 3 clinical VISION trial spark confidence in many experts.
An innovative collaboration has been formed in the UK between academic researchers and industry to develop a rapid integrated liquid biopsy platform for early detection of recurrent breast cancer. Breast cancer specialists Professor Charles Coombes, who is Professor of Medical Oncology at Imperial College London (ICL), and Professor Jacqui Shaw, Head of the Department of Genetics and Genome…
Leading functional & smart textile manufacturer Asiatic Fiber Corporation (AFC) introduces advanced wearable technology for electronic muscle stimulation (EMS) and transcutaneous electrical nerve stimulation (TENS): (EMS module / E-massage module) of the iQmax® series at the international trade fair MEDICA 2021, which will be held in Germany from November 15th to 18th.
The sharpest images ever of living bacteria have been recorded by researchers at University College London, revealing the complex architecture of the protective layer that surrounds many bacteria and makes them harder to be killed by antibiotics.
French researchers have found that addressing concerns related to the Covid-19 vaccination via a chatbot interface might be capable of swaying the vaccine-hesitant. Vaccine hesitancy is one of the major challenges in containing the Covid-19 pandemic. Previous studies have revealed that mass communication—through short messages relayed by television or radio—is not a very effective means of…
The skin bacterium Staphylococcus aureus often develops antibiotic resistance. It can then cause infections that are difficult to treat. Researchers at the University of Bonn have uncovered an ingenious way in which a certain strain of Staphylococcus aureus protects itself against the important antibiotic vancomycin. The results have now been published in the journal Microbiology Spectrum.
Researchers at the Catharina Heart and Vascular Center, together with Eindhoven University of Technology, have developed a new measurement method to analyze the smallest capillaries of the heart by measuring blood flow and resistance. The new method to assess coronary microcirculation allows cardiologists to make a clearer diagnosis. Until recently, the tests used for this purpose were not…
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance Prediction for Tuberculosis International Consortium (CRyPTIC) research project has collected the largest ever global dataset of clinical M.…
Making recommendations for change, academics analyzed global data into the prevalence of antimicrobial resistance in urban areas—the rise of which is threatening the lifesaving role of the medications.
Researchers at the Centre for Genomic Regulation (CRG) and Pulmobiotics S.L have created the first ‘living medicine’ to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria’s ability to cause disease and repurposing it to attack harmful microbes instead.
Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term. In some cases the tumors disappeared completely, researchers at the University of Zurich (UZH) and University Hospital Zurich (USZ) have found. Their findings will now be tested in…
Scientists have identified two subtypes of metastatic prostate cancer that respond differently to treatment.
Researchers have found a way to defeat the multi-resistant bacterium Mycobacterium abscessus, a relative of the causes of tuberculosis and leprosy.
Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to an immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.
IT networks of hospitals and other healthcare institutions are currently very much in the focus of both hackers and IT security specialists. In a healthcare landscape in which both organizational and medical heavily rely on IT, keeping networks safe is key to protecting patients’ data and lives.
Trainee trauma or orthopaedic surgeons have limited chances to practice hip replacement surgery before their first hands-on case. To change this, a team in the Dynamic HIPS project aim to improve this by creating a dynamic hip replacement simulator for future surgeons to practice the intervention and develop a reality-based feel for the procedure.
Infectious disease diagnostics are notoriously slow. The gold standard for laboratory diagnosis of bacterial and fungal infection involves growing the pathogen from a clinical specimen – an overnight event, or even longer. The healthcare focus is on improving the use of antibiotics for better patient outcomes and reducing the environmental pressures that drive antibiotic resistance. To impact…
On World Sepsis Day, in vitro diagnostics company bioMérieux and the UK Sepsis Trust reveal the results of a survey conducted in Europe regarding knowledge and attitudes towards sepsis. The findings demonstrate the need to accelerate awareness and education of the general population about this life-threatening condition.
A solid diagnosis has always been the first step on any patient’s journey to health. However, diagnostic categories are necessarily oversimplifications. In the last decades, medical professionals and scientists have begun to uncover the true variability in patients’ physiological and biochemical make-up that is the principal cause for individual variations in the way diseases present…
Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted. The polymer, developed by Prof. Dr. Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and Life Sciences Institute at the University of British Columbia, substantially diminished rejection of transplants in mice when…
Long considered an unnecessary organ, the appendix is now the focus of several studies that aim to better understand its role. Present in many mammals, including humans, it appears to have developed at least 16 times over the course of the evolutionary history of mammals, suggesting that its function must confer a positive selective advantage on those that have it. A new study carried out by…
Italy, France, and Greece have made Covid-19 vaccination mandatory for healthcare workers, and England is making it compulsory for care home workers and consulting on whether to extend this to healthcare workers and other social care staff. Experts debate in The BMJ whether frontline health and social care workers should be compelled to take up the vaccine, if efforts to encourage them fail.…
A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin…
A newly targeted therapy could help millions of lung cancer patients worldwide keep their cancers from spreading, says an expert at Cleveland Clinic, on the occasion of World Lung Cancer Day. Dr. Khaled Hassan, of the Hematology and Medical Oncology Department at Cleveland Clinic, explains the concept of KRAS targeted therapy – and why the approach should not be mistaken for a cancer cure.
A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial.
Antibiotic-resistant pathogens have become one of the greatest threats to public health. The basic mechanisms of resistance evolution have been well studied experimentally and are an important research field at Kiel University. An important factor in this context, but one that has received little attention so far, is the population size of the respective pathogen. Over the course of an infection…
Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in…
To advance anti-tuberculosis (TB) science and enable the progression of new, safe, and affordable treatment solutions for TB patients worldwide, a new consortium of 30 partners from 13 countries has officially launched. The 7-year, €185 million project called Unite4TB, aims to accelerate and improve the clinical evaluation of combinations of existing and novel drugs, with the goal of developing…
Cécile Geneviève is one of the few women who lead research and development (R&D) at a major company and her increasingly female team reflects women’s growing interest in the field. But while gender balance is an important criterion, it takes a broad palette of skills to innovate to alleviate pain for millions of patients, she explained in an interview with Healthcare in Europe.
Antibiotics have been at the heart of modern healthcare since the 1950s. They are prescribed prior to an operation to minimise the risk of infection after the operation. Or antibiotics are prescribed to fight an infection. This practice, which might seem straightforward at first glance, has proven to cause a number of problems itself: Over the last twenty years, it has become increasingly clear…
Miniature tumours in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. “We’ve solved a major problem many scientists had been facing: preserving a tumours original composition and structure outside of the patient in the lab”, says cancer researcher Daniela Thommen.
A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at Leeds. The mutated form of the RAS protein has been referred to as the “Death Star” because of its ability to resist treatments and is found in 96% of pancreatic cancers and 54% of colorectal cancers. RAS is a protein important for health but in its mutated form it can…
Blood cultures are important laboratory tests to diagnose serious infections. Contamination is a constant concern – a patient could be misdiagnosed due to a false-positive test. Initial specimen diversion (ISD) could radically change this.
An international research team from Saudi Arabia, Germany, and Jordan has developed a novel pathogen aptasensor swab designed to qualitatively detect, within five minutes, any methicillin-resistant Staphylococcus aureus (MRSA) contamination that remains in a hospital isolation room or other surface following standard decontamination and cleaning.
Researchers at RMIT University in Australia have developed smart wound dressings with built-in nanosensors that glow to alert patients when a wound is not healing properly. The multifunctional, antimicrobial dressings feature fluorescent sensors that glow brightly under UV light if infection starts to set in and can be used to monitor healing progress.
234 random passersby got the opportunity to try a new virtual reality game, when researchers from the University of Copenhagen visited Fælledparken to test the efficiency of VR technology within health information. During the event, the participants tried their strength against a new VR game that simulates the effect of herd immunity. The game is developed by researchers at the Virtual Learning…
The idea of visiting the doctor’s office with symptoms of an illness and leaving with a scientifically confirmed diagnosis is much closer to reality because of new technology developed by researchers at McMaster University. Engineering, biochemistry and medical researchers from across campus have combined their skills to create a hand-held rapid test for bacterial infections that can produce…
A new project led by University of California San Diego Biological Sciences graduate student Joshua Borin has provided evidence that phages that undergo special evolutionary training increase their capacity to subdue bacteria.
Mining the world's most comprehensive drug repurposing collection for Covid-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.
Researchers have shown that the life expectancy of mices can be increased by an average of 30% in both males and females. For humans, that would means that a 90-year-old could live until nearly 120.
Switching off a heart muscle protein could provide a new way for drugs to combat heart failure in people who’ve had a heart attack, according to research led by the University of Cambridge and published in the journal Nature. There is an unmet need to find drugs that can successfully improve the heart’s ability to pump blood efficiently after it’s been damaged following a heart attack.…
For the first time, a prospective, international study has shown that chest pain caused by problems with the very small vessels supplying blood to the heart is an important health problem that increases the risk of heart attacks, stroke and death due to cardiovascular reasons. The study, which is published in the European Heart Journal, recruited 686 patients from 14 institutions in seven…
By 2030, the most lethal form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDAC), is projected to become the second leading cause of cancer-related deaths in the United States. Not only are therapeutic options limited, but nearly half of PDAC patients who have their tumors removed surgically experience disease recurrence within a year, even with chemotherapy. For more advanced stages,…
Using higher doses of antibiotics in a bid to tackle the growing problem of drug resistance may end up strengthening certain bacteria, according to research that highlights a previously unthought-of risk.
Delaying the second dose of Covid-19 vaccines, at least for people aged under 65, could result in up to 20% lower mortality, but only under certain conditions, finds a US study published by The BMJ. These conditions include a one dose vaccine effectiveness (efficacy) of 80% or higher and vaccination rates of 0.1% to 0.3% of the population per day. If these conditions apply, the researchers say…
Researchers used AI to identify which daily changing clinical parameters best predict intervention responses in critically ill Covid-19 patients. The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve…
Researchers at Chalmers University of Technology, Sweden, have developed a new material that prevents infections in wounds – a specially designed hydrogel, that works against all types of bacteria, including antibiotic-resistant ones. The new material offers great hope for combating a growing global problem. The World Health Organization describes antibiotic-resistant bacteria as one of…
Antibiotic resistant bacteria are a looming super threat – heralding a time when our drugs will no longer be effective against prevalent infections. Hospitals are already coping with treatment-resistant bacterial infections. Cognizant of the threat and thinking outside the box, BGU scientists and German and American colleagues have developed a pair of 'molecular tweezers' to destroy the biofilm…
Should outdoor face covering be normalised to reduce transmission of SARS-CoV-2—or should anti-Covid efforts rather focus on indoor protection? Experts argue the case for both sides in this controversial debate.
Diagnostic data from the massive amounts of testing being conducted can help make health systems more resilient in dealing with future health crises and pandemics. The importance of diagnostic data was explored during the Medtech Europe online session, “Unlocking the Value of Diagnostic Information – how to make European Health Systems more resilient?” where delegates heard that…
Researchers from Tel Aviv University have created an artificial intelligence platform that can identify the specific proteins that allow bacteria to infect the intestines.
With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs. A team of researchers at the College of Medicine at the University of Oklahoma has published a new study in the journal…
The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to a new report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria.…
An increasing number of bacterial pathogens are resistant to antibiotics. And the most dangerous pathogens share a common feature: a double membrane that is difficult to penetrate. Even when antibiotic agents are able to break into this shell, the bacteria just pump them right out again. But a recently discovered compound called Darobactin manages to circumvent these protective measures and kill…
Any future attempts to reduce the spread of Covid-19 should be focused on tackling close airborne transmission of the virus which is considered to be the primary route for its circulation, according to experts. Respiratory experts argue that it is now clear that SARS-CoV-2 is most likely to transmit between people at close range through inhalation rather than through contact with surfaces or…