Search for: "cancerous tissue" - 1000 articles found

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Article • Imaging in characterisation and classification of tumour types

Taking a closer look at breast cancer

Breast cancer has no “one size fits all” therapy approach: subtypes differ significantly in malignancy, progression, and treatment response. Therefore, the more is known about the type of carcinoma in a patient, the better the outcome. At the annual scientific EUSOBI meeting in Valencia, Dr Ramona Woitek pointed out the potential of novel imaging techniques and computational image analysis…

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Article • Imaging controversial

MRI breast cancer screening of high-risk women: benefits outweigh drawbacks

Breast MRI is increasingly being used as a primary breast cancer screening exam for young women. It brings benefits in women with dense breasts, who are at an elevated risk of developing breast cancer. The technique is also being ordered as a supplemental screening exam following mammography or breast ultrasound for women of all ages at high risk. But use of breast MRI as a screening tool is…

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Article • During lumpectomy

Fluorescence-guided surgery identifies breast cancer in margins

Breast surgery is a traumatic experience for a woman, no matter whether breast-conservation surgery (BCS) or a mastectomy. Trauma levels are greatly enhanced, if pathological evaluation findings of an excised breast tumour following a lumpectomy suggest that additional cancer may still be in the margins, and a second surgical procedure is required. A new system with the ability to accurately…

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Article • Knowledge gaps in gender medicine

Covid-19 and sex: higher mortality of male patients

The Covid-19 pandemic has affected scientific research in numerous ways – for example by highlighting knowledge gaps in gender medicine. In many studies differences in morbidity and mortality between women and men surfaced incidentally. While the extent and causes of these differences remain largely unexplored, the preliminary insights confirm the need for further research.

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Article • Need for diversity in training datasets

Artificial intelligence in healthcare: not always fair

Machine learning and artificial intelligence (AI) are playing an increasingly important role in medicine and healthcare, and not just since ChatGPT. This is especially true in data-intensive specialties such as radiology, pathology or intensive care. The quality of diagnostics and decision-making via AI, however, does not only depend on a sophisticated algorithm but – crucially – on the…

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Article • RFA, MWA, CRYO and IRE under scrutiny

Thoracic interventions: new tools in the arsenal

Experts presented state-of-the-art and emerging techniques to treat chest tumours and discussed common issues in the management of pneumothorax at RSNA 2022. Current ablation methods in the thorax include radiofrequency ablation (RFA), microwave ablation (MWA), cryoablation (CRYO), irreversible electroporation (IRE) and pulsed electric field.

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Article • Supplemental imaging

The next breast screening advancement: Contrast-enhanced mammography

With the recent recommendation changes from the European Council in 2022, how radiologists screen for breast cancer is changing. Mammography has long been an essential technology in screening for breast cancer, and in the recommendations the Council formally recognized the advantages of digital breast tomosynthesis (DBT). This landmark acknowledges the research on and benefits of DBT, advocating…

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Article • Flow cytometry

Detecting and measuring nanoplastics in the blood stream

Plastics are a part of everyday life, and an increasingly concerning factor of global environmental pollution. They also have infiltrated our bodies as microparticles (MPs) and nanoparticles (NPs), found even in placentas supporting foetal life. And they are in our blood. Now, researchers in Spain have developed a new method to detect and measure nanoparticles in human peripheral blood that is…

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Article • Progress, limitations, and opportunities

Precision oncology: incredible potential, but not a miracle cure

Unanswered questions are hampering clinicians in their efforts to get the best out of a precision medicine approach for their patients. Speaking at the Genomics and Precision Medicine Expo in London at the end of May, cancer educator Dr Elaine Vickers said the benefits of being matched to an investigational drug remain questionable for most people with advanced cancer.

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Article • Digital breast tomosynthesis (DBT)

New EU recommendations for breast screening enhance opportunities for early detection

Mammography has been an essential imaging technology for breast cancer detection for decades. As the industry has continued to innovate, one advancement in mammography has particularly changed the landscape of breast imaging: digital breast tomosynthesis (DBT), also known as 3D mammography.

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Article • Cervix, vulva and vagina

More certainty with methylation tests for early detection of cancer

A second-generation lab test for early detection of cervical cancer is the most recent addition to Oncgnostics’ portfolio. In particular, the company’s solution will help women in countries with limited cancer screening. Moreover, new research on the early detection of vulval and vaginal cancer might soon enable the development of tests for these cancers.

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Article • Centralised image library and archive

From regional to national: digital pathology network transformation

Transforming a regional digital pathology network into a national programme across the UK has the potential to save the NHS around £100m a year. Such a network – one that sees a centralised digital pathology image library and archive, as opposed to individual hospitals having their own infrastructure and teams to manage it – can also offer a range of other benefits alongside significant cost…

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News • Promising reseach results

Using artificial DNA to kill cancer

Researchers at the University of Tokyo have used artificial DNA to target and kill cancer cells in a completely new way. The method showed promising results against various cancers in lab tests on mice.

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Article • Cancer screening

The need for breast imaging for transgender patients

The need for breast cancer screening of transgender individuals has been a topic of uncertainty until recently, due to lack of reliable patient data, consensus by radiologists, published research, and recommended guidelines. A 2021 survey of Society of Breast Imaging (SBI) members revealed that ‘breast radiologists differ in their practice and knowledge regarding screening of transgender…

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Article • Digitisation in the OR

Robotic duo pushes boundaries of microsurgery

One robot supports the surgeon’s control of tiny instruments, while another automatically keeps an eye on what is happening: With this novel combination, surgeons in Münster have successfully performed fully robot-assisted microsurgery for the first time. Presenting the new procedure at the Hornheide Specialist Clinic, the experts explain how the interaction of both robotic systems ensures…

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Article • Tissue-engineered glioblastoma model

3D brain tumour in a dish to personalize cancer treatment

It is the size of a common pencil eraser, but it could have a huge impact on the therapy of glioblastoma: Scientists in Virginia have developed a novel 3D tissue-engineered model of the brain tumour microenvironment, which can be used to assess how the glioma cell invades healthy tissue, proliferates, and reacts to chemotherapy drugs.

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Article • Visceral imaging

Endosonography: AI takes on the “supreme discipline”

Endosonography poses unique challenges for medical professionals, because two demanding disciplines have to be mastered at the same time. The use of artificial intelligence (AI) could help speed up the notoriously slow learning curve of the procedure, says Prof Dr Christoph F. Dietrich. At the Visceral Medicine Congress in Hamburg, the expert explained how AI can help endosonography achieve…

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Article • AI provides prognostic information

Next-generation deep learning models predict cancer survival

Deaths from cancer are currently estimated at 10 million each year worldwide. Conventional cancer staging systems aim to categorize patients into different groups with distinct outcomes. ‘However, even within a specific stage, there is often substantial variation in patient outcomes,’ Markus Plass, academic researcher from the Medical University of Graz, Austria, explained to Healthcare in…

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Malignant tumour management

’Our machine learning model achieved 88.9% accuracy in predicting the sarcoma-specific survival rate’

Clinical management of soft tissue sarcoma is particularly challenging. Dr Sebastian Foersch, researcher at the Institute of Pathology at the University Medical Center in Mainz, Germany, has used a deep learning model for diagnosis and prognosis prediction of soft tissue sarcoma using conventional histopathology slides.

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Supervised learning approach

A new deep learning-based algorithm to predict relapse-free survival in papillary thyroid carcinoma

The tall cell variant (TCV) is an aggressive subtype of papillary thyroid carcinoma (PTC). Sebastian Stenman, researcher from the Institute for Molecular Medicine, and the Department of Pathology at the University of Helsinki, Finland, is developing and training a deep learning algorithm using supervised learning to detect and quantify the proportion of tall cells in PTC.

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News • Assessing bone quality via blood sampling

New device for diagnosing bone fragility

A new device for diagnosing bone fragility invented by the University Hospitals of Geneva (HUG) and the University of Geneva (UNIGE) has been approved for marketing in the European Economic Area and Switzerland. The device is based on a new approach to assessing bone quality via blood sampling.

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News • Alveolar rhabdomyosarcoma

Promising new treatment for deadly pediatric tumor

Alveolar rhabdomyosarcoma is a rare pediatric tumor. For more than 40 years there has not been any new development regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now identified a new therapeutic option, using a drug that is currently under investigation for other types of cancer.

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Article • Key technologies

Artificial intelligence in medicine will prevail

Artificial intelligence (AI) is changing our healthcare systems. It can help us detect diseases earlier, improve patient care and reduce healthcare costs. However, there is still a lack of trust, of rules and safety regulations and of broad data pools. How can we use AI successfully in healthcare systems and what role will it play in the future?

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News • Chemotherapy approach

New receptor insights might leave cancer bitter

Bitter taste receptors do not only support humans in tasting. They are also found on cancer cells. A team led by Veronika Somoza from the Faculty of Chemistry at the University of Vienna and the German Leibniz Institute for Food Systems Biology at the Technical University of Munich has investigated the role they play there. For this purpose, the scientists compiled and evaluated extensive…

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News • Conducting diagnostics

Detecting breast cancer via electrical currents in the skin

Mammograms are a safe, effective way to detect the presence of breast cancer in women. But doctors recommend most females should start getting mammograms after the age of 40 in part because the procedure involves small doses of ionizing radiation. While the risk of getting breast cancer is higher for older people, it can strike at any age. Studies show that 5% to 7% of females with breast cancer…

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News • Breast MRI study

IUDs have systemic effects on the body

Intrauterine contraceptive devices (IUDs) appear to have systemic effects on the body like those of hormone replacement therapy, according to a breast MRI study being presented at the annual meeting of the Radiological Society of North America (RSNA).

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Article • Focused ultrasound

Histotripsy: fighting tumors with microbubbles

Focused ultrasound waves create microbubbles in a fluid – a phenomenon called cavitation. In a current study, this process is used to destroy liver tumors and metastases. In this Medica-tradefair.com interview, Prof. Maciej Pech talks about testing cavitation events generated during histotripsy, explains the process, and reveals its advantages.

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Article • Pre-, post- and interoperative

Wearable devices in the surgical environment

Wearable technology has become an important part of medicine, from tracking vital signs to disease diagnosis. In surgery, wearable technologies can now assist, augment, and provide a means of patient assessment before, during and after surgical procedures. Wearable technologies are applied before the patient even reaches the operating room, for example in prehabilitation, i.e. pre-treatment…

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News • Coronavirus imaging

Brightest ever X-ray shows lung damage from Covid-19

The damage caused by Covid-19 to the lungs’ smallest blood vessels has been intricately captured using high-energy X-rays emitted by a special type of particle accelerator. Scientists used a new imaging technology called Hierarchical Phase-Contrast Tomography (HiP-CT), to scan donated human organs, including lungs from a Covid-19 donor.

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News • Metastasis research

Study reveals risk of breast cancer spreading to other parts of the body

The risk of early breast cancer spreading to another part of the body ranges from 6% to 22%, according to the first results of a large and detailed global study of metastatic breast cancer presented at the Advanced Breast Cancer Sixth International Consensus Conference (ABC 6). The study also shows that certain women face a higher risk than others, including women diagnosed with breast cancer at…

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Video • Prevention of triple-negative BRCA

Breast cancer vaccine: clinical trial started

Researchers from Cleveland Clinic have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body’s immune response. The…

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News • 3D microelectrodes

Promising approach for pain relief without side effects

Researchers at Lund University in Sweden have developed a completely new stimulation method, using ultra-thin microelectrodes, to combat severe pain. This provides effective and personalised pain relief without the common side effects from pain relief drugs. The study, which was conducted on rats, has been published in the research journal Science Advances.

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Article • Mass spectrometry goes handheld

A pen to pin down the fringes of cancer

Mass spectrometry – a powerful tool for analysing the molecular composition of a tissue sample – is invaluable during cancer surgery. However, mass spectrometers are complex and unwieldy, and certainly a poor fit for an operating room (OR). To create a bridge between the lab and OR, Professor Livia S Eberlin, from Baylor College of Medicine, has developed a very special ‘pen’.

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Article • Covid-19 and pathology

Lung cancer care across Europe affected by coronavirus pandemic

The impact of the coronavirus pandemic on lung cancer patient care across Europe, and the contribution lung pathologists, have led to a better understanding of Covid-19, as outlined during the 33rd European Congress of Pathology, Within ‘The lung pathologist in the Covid-19 pandemic’ session, speakers detailed how the pandemic has affected patients, diagnosis and clinical trials, yet also…

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Sponsored • Customer reference

Benefits of Digital Pathology and the importance of slide preparation

In recent years, digital pathology has become increasingly recognised as a clinical diagnostic tool and has taken a crucial role in pathology laboratories. One of the early adopters of digital pathology is the Department of Clinical Genetics and Pathology, Office for Medical Services, Region Skåne, a multisite Swedish laboratory which produces over 800,000 histopathology slides per year. The…

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News • Organoid research

Structure formation in mini-organs

Many of the organ systems found in animals exhibit highly complex structures, which are essential for their various functions. How such structures develop during embryonic development is a central question in biology. Physicists led by Erwin Frey (Professor of Statistical and Biological Physics at LMU Munich) and Andreas Bausch (Professor of Cellular Biophysics at the Technical University of…

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News • Personalised aftercare

Immunosuppression after transplant: as much as necessary, as little as possible

After a liver transplant, patients have to take immune-suppressing drugs for the rest of their lives. These so-called immunosuppressants prevent the organ from being rejected. However, the drugs increase the risk of cancer and serious infections. They can also significantly impair kidney function and even lead to dialysis. In order to be able to give those affected as much immunosuppression as…

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News • Histological grading assistance

AI improves precision in breast cancer diagnosis

Researchers at Karolinska Institutet have developed an AI-based tool that improves the diagnosis of breast cancer tumours and the ability to predict the risk of recurrence. The greater diagnostic precision can lead to more personalised treatment for the large group of breast cancer patients with intermediate risk tumours. The results are published in the scientific journal Annals of Oncology.

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News • Ductal adenocarcinoma

Pancreatic cancer ‘priming’ may make chemotherapy more effective

A new approach to ‘prime’ the tumour environment may improve how effective chemotherapy is for pancreatic ductal adenocarcinoma, one of the most aggressive forms of pancreatic cancer. In preclinical models, a team at the Garvan Institute of Medical Research could enhance the tumours’ response to chemotherapy by reducing the stiffness and density of the connective tissue known as the stroma,…

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News • Promising algorithm

AI tool improves breast cancer imaging accuracy

A computer program trained to see patterns among thousands of breast ultrasound images can aid physicians in accurately diagnosing breast cancer, a new study shows. When tested separately on 44,755 already completed ultrasound exams, the artificial intelligence (AI) tool improved radiologists’ ability to correctly identify the disease by 37 percent and reduced the number of tissue samples, or…

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News • Classifying subtypes

Breast cancer ‘ecotypes’ could lead to more personalised treatment

A team led by the Garvan Institute of Medical Research has revealed a new approach for classifying breast cancer subtypes based on their cell profile, which could help personalise treatments for patients. By analysing breast cancer biopsies from patients at Sydney hospitals, the researchers revealed more than 50 distinct cancer, immune and connective cell types and states, which could assign…

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News • Patient response testing

New method predicts which cancer therapies work (and which don't)

A new technology that can study which therapies will work on patients with solid cancerous tumours has been developed by scientists at University College London (UCL). Researchers say the tool, which can rapidly test tumorous tissue against different treatments, such as chemotherapy, immunotherapy or radiotherapy, could be used by clinicians to pinpoint the best therapy for a particular patient.

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News • Understanding oncogenesis

How normal cells turn into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients. Previous studies have achieved this only by using powerful viral factors that are not common in human cancers. Since many human cancer types still lack specific diagnostic…

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News • Reducing collateral damage

A shield to protect patients during prostate cancer radiotherapy

Prostate cancer specialists from the Radiotherapy Department at Norfolk and Norwich University Hospitals Foundation Trust have become the first in the world to use an innovative technique to help patients receiving treatment for prostate cancer. Some patients receiving radiotherapy for prostate cancer will have their treatment split into two portions. The first stage of killing the cancerous…

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Article • Precision oncology

Personalized health and genomics: Minimizing collateral damage

A solid diagnosis has always been the first step on any patient’s journey to health. However, diagnostic categories are necessarily oversimplifications. In the last decades, medical professionals and scientists have begun to uncover the true variability in patients’ physiological and biochemical make-up that is the principal cause for individual variations in the way diseases present…

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News • Brain cancer research

Researchers 3D-print entire active tumor

Researchers at Tel Aviv University have 3D-printed a first-of-its-kind glioblastoma tumor that mimics a living cancer malignancy, powering new methods to improve treatment and accelerate the development of new drugs for the most lethal type of brain cancer. Glioblastoma is notoriously fatal as it accounts for the majority of brain tumors and is highly aggressive. The average survival time of…

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Article • Omics in cancer care

Personalizing laboratory medicine

To avoid adverse reactions, personalised laboratory medicine can help to predict a patient’s drug response. Investigations based on DNA and other omics technologies – e.g. genomics, transcriptomics, proteomics, metabolomics – along with microarray technologies, is making a particularly valuable contribution to cancer care, in which personalised approaches are becoming possible through…

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News • Cell delivery vehicles

Bio-inspired nanocontainers could enter cells and release their medical cargo

Nanocontainers can transport substances into cells where they can then take effect. This is the method used in, for example, the mRNA vaccines currently being employed against Covid-19 as well as certain cancer drugs. In research, similar transporters can also be used to deliver labelled substances into cells in order to study basic cellular functions. To take advantage of their full potential,…

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News • Tool to identify tumour mutations

Machine learning fuels personalised cancer medicine

The Biomedical Genomics laboratory at the Institute for Research in Biomedicine (IRB) Barcelona has developed a computational tool that identifies cancer driver mutations for each tumour type. This and other developments produced by the same lab seek to accelerate cancer research and provide tools to help oncologists choose the best treatment for each patient. The study has been published in the…

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News • Angiogenesis

Magnetic stimulation boosts blood vessel formation

Magnetic fields can be used to stimulate blood vessel growth, according to a new study. The findings, published in the journal Science and Technology of Advanced Materials by researchers at the Técnico Lisboa and NOVA School of Science and Technology in Portugal, could lead to new treatments for cancers and help regenerate tissues that have lost their blood supply.

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News • Personalizing treatment

AI can help improve precision radiotherapy

The Netherlands Cancer Institute, University of Amsterdam (UvA), and Elekta will collaborate on the development of new AI strategies for the further improvement of precision radiotherapy. This concerns the personalization of treatment by improving the quality of imaging used during treatment, predicting and accounting for changes in the patient’s anatomy over time, and automatically adapting…

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News • Genetic alterations

Same mutation, different cancers: researchers explore connections

Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in…

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News • Tumour development research

New bladder cancer model could lead to better treatment

Uppsala University scientists have designed a new mouse model that facilitates study of factors contributing to the progression of human bladder cancer and of immune-system activation when the tumour is growing. Using this model, they have been able to study how proteins change before, while and after a tumour develops in the bladder wall. The study has now been published in the scientific…

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News • Neoadjuvant chemotherapy

Breast cancer: New test predicts therapy success

In a collaboration with the Faculty of Statistics at TU Dortmund and the University Medical Center in Mainz, a research team at the Leibniz Research Centre for Working Environment and Human Factors in Dortmund (IfADo) has developed a test that can be used to predict the success of therapy for breast cancer. Breast cancer is one of the most common tumour diseases worldwide. One in eight women will…

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News • CADU vs cancer

Detecting oesophageal cancer with AI

Experts at University College London (UCL) and spinout company Odin Vision working with clinicians at UCLH have used artificial intelligence (AI) to help detect early signs of oesophageal cancer. The first procedure in the world using the AI technology was performed at University College Hospital by UCLH consultant gastroenterologist Dr Rehan Haidry. The system, called CADU, uses AI to support…

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News • Promising research tool

World's first digital cancer cell model

Computer models have been standard tools in basic biomedical research for many years. However, around 70 years after the first publication of an ion current model of a nerve cell by Hodgkin & Huxley in 1952, researchers at Graz University of Technology (TU Graz), in collaboration with the Medical University of Graz and the Memorial Sloan Kettering Cancer Center in New York, have finally…

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News • Oncology early detection tool

Blood test for 50+ types of cancer promising for screening

Final results from a study of a blood test that can detect more than 50 types of cancer have shown that it is accurate enough to be rolled out as a multi-cancer screening test among people at higher risk of the disease, including patients aged 50 years or older, without symptoms. In a paper published in the cancer journal Annals of Oncology, researchers report that the test accurately detected…

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News • Unexpected find

Anti-tapeworm drug shows promise against Covid-19

Researchers from the German Center for Infection Research (DZIF) at Charité – Universitätsmedizin Berlin and the University of Bonn have examined the way in which SARS-CoV-2 reprograms the metabolism of the host cell in order to gain an overall advantage. According to their report in Nature Communications, the researchers were able to identify four substances which inhibit SARS-CoV-2…

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Article • Digital pathology

Today’s tissue for tomorrow’s research

Specialist biorepositories are helping advance personalised medicine by supporting the availability of human tissue for research using digital pathology techniques. The pivotal role of the Glasgow Tissue Research Facility (GTRF) in making tissue available to shape new therapies and treatments was outlined in a presentation to the online “Transforming Digital Pathology – Integrating AI to Move…

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News • Donor organ analysis

New laser technique could improve liver transplant process

Handheld laser devices that help surgeons quickly spot liver damage could transform transplant procedures, research suggests. The non-invasive technique could provide medical staff with instant data on the health of donor livers and help them to identify which organs are suitable for transplant. If widely adopted, the light-based tool could allow more livers to be transplanted safely and…

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News • Safe sonography

Medical societies support safety and benefits of ultrasound contrast agents

The American Institute of Ultrasound in Medicine (AIUM) and the American Society of Echocardiography (ASE) have joined the International Contrast Ultrasound Society (ICUS) in recognizing the relatively low risk and important clinical benefits of ultrasound contrast agents (UCAs), which are used routinely around the world to help detect heart disease, stratify the risk of heart attack or stroke,…

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News • Oncology meets history

Medieval cancer rates much higher than previously thought

CT scanning used to uncover remnants of malignancy hidden inside medieval bones provides new insight into cancer prevalence in a pre-industrial world. The first study to use x-rays and CT scans to detect evidence of cancer among the skeletal remains of a pre-industrial population suggests that between 9-14% of adults in medieval Britain had the disease at the time of their death. This puts cancer…

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News • Regeneration research

Scientists uncover how our skin repairs itself

University of Manchester scientists have cast new light on how our skin repairs itself, bringing the possibility of regeneration of the organ a step closer. The study team, funded by the Medical Research Council and Helmut Horten Foundation, showed the activation of specific parts of the DNA leading to better division of human skin cells. The study is published in Nucleic Acid Research.

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News • Esophagitis

Lung cancer: Tailoring radiation therapy to reduce complications

For many patients with localized lung cancer (non-small-cell lung carcinoma and small cell lung carcinoma), high-dose radiation with concurrent chemotherapy is a potential cure. Yet this treatment can cause severe, acute inflammation of the esophagus (esophagitis) in about one in five patients, requiring hospitalization and placement of a feeding tube. A team of radiation oncologists at Mass…

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Video • Bioprinting breakthrough

3D printed mini pancreas to help fight diabetes

First you see it as a transparent shape on a computer screen – a small electronic replica of the human pancreas. Then just 30 seconds later the tissue is printed out on a bioprinter, blood vessels and all, from a sample of human stem cells. This amazing feat is possible thanks to new technology created at EPFL’s Laboratory of Applied Photonics Devices (LAPD) and further developed by…

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News • Combining MRI with particle beams

An important step towards live imaging in proton therapy

Researchers at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) want to build the world’s first prototype that tracks moving tumors with magnetic resonance imaging (MRI) in real time during proton therapy. They are combining a rotating open MRI device, designed for the LINAC-MR system from Alberta Health Services, with an actively scanned clinical-akin proton beam at OncoRay, the Dresden-based…

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Sponsored • Mammography

Advancing the Breast Continuum of Care

The pandemic has presented healthcare systems with new challenges, resulting in backlogs of routine screenings and delayed procedures which threaten the health and wellbeing of patients, as well as the ability of facilities to serve their communities. In order to address these widespread issues, we need to ensure that healthcare professionals are able to operate with precision, confidence and…

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News • CRISPR-Cas9

An 'on-off switch' for gene editing

Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms’ DNA. While the system could potentially be useful in treating a variety of diseases, CRISPR-Cas9 editing involves cutting DNA strands, leading to permanent changes to the cell’s genetic material. Now, in a paper published online in Cell,…

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News • Radiology research

Chest CT illuminates COPD mortality risk

Body composition information derived from routine chest CTs can provide important information on the overall health of people with chronic obstructive pulmonary disease (COPD), including their risk of all-cause mortality. This is the result of a new study, published in Radiology. COPD is a group of chronic, progressive lung diseases that affect about 30 million people in the United States alone.…

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News • Here comes the tooth fairy

New drug shows promise for regenerating lost teeth

A new study by scientists at Kyoto University and the University of Fukui may offer hope for adults who have lost their teeth. The team reports that an antibody for one gene - uterine sensitization associated gene-1 or USAG-1 - can stimulate tooth growth in mice suffering from tooth agenesis, a congenital condition. The paper was published in Science Advances. Although the normal adult mouth has…

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Video • Uprooting cancer

New hydrogel 'reprograms' cancer cells back to cancer stem cells

An innovative hydrogel – called a double network (DN) gel – can rapidly reprogram differentiated cancer cells into cancer stem cells, researchers at Hokkaido University and the National Cancer Center Research Institute have reported in the journal Nature Biomedical Engineering. The hydrogel can be used to help develop new cancer therapies and personalized medicines targeting cancer stem cells.

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News • Malignant brain tumor

Successful test for mutation-specific vaccine against diffuse gliomas

Tumor vaccines can help the body fight cancer. Mutations in the tumor genome often lead to protein changes that are typical of cancer. A vaccine can alert the patients' immune system to these mutated proteins. For the first time, physicians and cancer researchers from Heidelberg and Mannheim have now carried out a clinical trial to test a mutation-specific vaccine against malignant brain tumors.…

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News • Acidity analysis

Harnessing AI to identify cancer cells

Healthy and cancer cells can look similar under a microscope. One way of differentiating them is by examining the level of acidity, or pH level, inside the cells. Tapping on this distinguishing characteristic, a research team from the National University of Singapore (NUS) has developed a technique that uses artificial intelligence (AI) to determine whether a single cell is healthy or cancerous…

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News • BMMF research

Novel pathogens: a driver for colorectal cancer?

Do BMMFs, the novel infectious agents found in dairy products and bovine sera, play a role in the development of colorectal cancer? Scientists led by Harald zur Hausen detected the pathogens in colorectal cancer patients in close proximity to tumors. The researchers show that the BMMFs trigger local chronic inflammation, which can cause mutations via activated oxygen molecules and thus promote…

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News • Singlet contrast imaging

Hyperpolarized MRI enables real-time view on metabolic processes

Hyperpolarized MRI is a recent development and its research and application potential has yet to be fully explored. Researchers at Johannes Gutenberg University Mainz (JGU) and the Helmholtz Institute Mainz (HIM) have now unveiled a new technique for observing metabolic processes in the body. Their singlet-contrast MRI method employs easily-produced parahydrogen to track biochemical processes in…

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Article • At ECR 2021

AI experts tackle organ segmentation and health economics

AI is revamping workflows and experts showed how radiologists can integrate it into their department to improve daily practice and healthcare at ECR. The panel also discussed the health economics side of AI to help radiologists define which products make more economic sense for their department. The session tackled automated organ segmentation, an interesting application for AI in radiology.

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News • Breast cancer diagnostics

New system to make AI diagnosis explainable

Researchers at TU Berlin and Charité – Universitätsmedizin Berlin as well as the University of Oslo have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). Two further developments make this system unique: For the first time, morphological, molecular and histological data are integrated in a single analysis. Secondly, the system…

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News • Tiny changes, huge effects

Finding causes of disease with induced pluripotent stem cells

Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors. Tens of…

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Article • Earlier, better insights

New developments in whole-body MRI for prostate cancer

Whole-body magnetic resonance imaging (WB-MRI) can detect prostate cancer and inform about treatment response and disease progression earlier and better than other imaging modalities. A Belgian expert will delve into the latest and future developments of the technique for prostate cancer and distant metastases imaging in a dedicated session at ECR. WB‐MRI and nuclear medicine -…

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Article • Imaging tumour metabolism

Hyperpolarised MRI boosts cancer diagnosis

Tumour metabolism can be imaged with MRI as a technique to help determine cancer aggressiveness and response to therapy. The work by a UK-based group, on probing cancer metabolism non-invasively with clinical hyperpolarised carbon-13 MRI, can detect metabolic changes in the tumour. As metabolic changes occur much earlier than change in tumour size, this could have implications for quicker…

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Article • AI tool might reduce surgery

Managing cancer-questionable breast lesions

The management of biopsied breast lesions that are diagnosed as abnormal but are not definitively malignant is challenging and controversial. Treatment ranges from diligent follow-up, with imaging and subsequent biopsy, to surgical excision. Researchers at the Medical University of Vienna (Medizinische Universität Wien), Austria, have developed and validated a software algorithm designed to…

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News • Collagen 'pushing'

Supercomputer illustrates mechanical process of cancer growth

According to the World Health Organization, one in six worldwide deaths have been attributed to cancer; however, these fatalities were not due to initial malignant tumors—the deaths were caused by the spread of cancer cells to surrounding tissues and subsequent tumor growth. These tissues, which consist largely of collagen, have been the focus of a recent collaborative study by a team from…

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News • Software solution

New solutions for breast image reading and mammography workflow optimization

Siemens Healthineers has introduced a new software solution that speeds up the entire reading workflow for breast imaging: Mammovista B.smart. Also new is the Teamplay Mammo Dashboard, a tool for dashboard-based visualization of key performance indicators (KPIs) in the breast imaging process that serves to optimize workflows. With these two new solutions, the company is extending its digital…

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Video • Multiphoton microscopy gives new insights

Microscopic behaviour of developing breast cells uncovered

An improved high-tech fluorescence microscopy technique is allowing researchers to film cells inside the breast as never seen before. This new protocol provides detailed instructions on how to capture hi-res movies of cell movement, division and cooperation, in hard-to-reach regions of breast tissue. The technology – called multiphoton microscopy – uses infrared lasers to illuminate…

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News • Curbing collaterals

High energy radiotherapy ‘paints’ tumours, avoids healthy tissue

A radiotherapy technique which ‘paints’ tumours by targeting them precisely, and avoiding healthy tissue, has been devised in research led by the University of Strathclyde. Researchers used a magnetic lens to focus a Very High Electron Energy (VHEE) beam to a zone of a few millimetres. Concentrating the radiation into a small volume of high dose will enable it to be rapidly scanned across a…

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News • Brain tumour analysis

Glioblastoma '3D maps' help find new therapies

Researchers at the Universitat Autònoma de Barcelona obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies.

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News • Physics of tumours

How cancer cells shape-shift to squeeze through tissue

Working with colleagues from Germany and the US, researchers at Leipzig University have achieved a breakthrough in research into how cancer cells spread. In experiments, the team of biophysicists led by Professor Josef Alfons Käs, Steffen Grosser and Jürgen Lippoldt demonstrated for the first time how cells deform in order to move in dense tumour tissues and squeeze past neighbouring cells. The…

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News • From science fiction to reality

Researchers develop powerful pocket-sized imaging device

Before Wilhelm Röntgen, a mechanical engineer, discovered a new type of electromagnetic radiation in 1895, physicians could only dream of being able to see inside the body. Within a year of Röntgen’s discovery, X-rays were being used to identify tumors. Within 10 years, hospitals were using X-rays to help diagnose and treat patients. In 1972, computed tomography (CT) scans were developed. In…

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News • Nuclear medicine

Targeted cancer therapy: Researchers speed up astatine-211 purification

In a recent study, researchers at the Texas A&M University have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.

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News • Surgical endoscopy

Olympus to acquire Quest Photonic Devices

Olympus Corporation announced that it has entered into an agreement to acquire Quest Photonic Devices B.V. for up to EUR50 million including milestone payments to strengthen its surgical endoscopy capabilities. Quest offers advanced fluorescence imaging systems (FIS) for the medical field, enabling more surgical endoscopy capabilities, compared to conventional imaging technologies.

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News • Mapping the 'family tree' of cancer

Metastasis monitoring: CRISPR tool catches cancer 'in the act'

When cancer is confined to one spot in the body, doctors can often treat it with surgery or other therapies. Much of the mortality associated with cancer, however, is due to its tendency to metastasize, sending out seeds of itself that may take root throughout the body. The exact moment of metastasis is fleeting, lost in the millions of divisions that take place in a tumor. “These events are…

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Article • He who seeks, finds

Pros and cons of MRI in breast cancer diagnosis

MRI is the most sensitive method to detect breast cancer. However, the current breast cancer guidelines for Europe, Germany and Austria, still only recommend it for certain indications: For early detection in high risk patients, for differentiation between scarring and recurrences after breast-conserving treatment and to detect cancers of unknown primary site. This is the theory. However, in…

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News • An unexpected and novel target

How our biological clock could save us from prostate cancer

Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It’s no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the…

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News • RNA editing

New mechanism of cancer formation discovered

A team of scientists at the National University of Singapore (NUS) led by Dr Polly Leilei Chen from the Cancer Science Institute of Singapore and Yong Loo Lin School of Medicine has discovered a previously unknown mechanism of cancer formation, the understanding of which may lead to more effective treatment. Their findings concern a process called RNA editing. The DNA code of a gene gets…

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News • RadClip

AI tool for MRI could transform prostate cancer surgery, treatment

Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer. The tool, called RadClip, uses AI algorithms to examine a variety of data, from MRI scans to molecular…

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Article • Applications of machine learning

Training AI to predict outcomes for cancer patients

Predicting cancer outcome could help with a clinical decision regarding a patient’s treatment. In his keynote speech during the online ‘7th Digital Pathology and AI Congress: Europe’, Johan Lundin, Research Director at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki and Professor of Medical Technology at Karolinska Institute, discussed ‘Outcome and…

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Article • Digital pathology

An exciting new era for tissue microarrays

A new generation of tissue microarrays are delivering more efficient and time-effective solutions to answering complex clinical and scientific questions. Sitting at the core of this new approach is digital pathology, allowing specific and targeted analysis of small areas of tissue.

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Article • Machine learning advances diagnostics and prognostics

Computerized image analysis can predict cancer outcomes

The advent of digital pathology is offering a unique opportunity to develop computerized image analysis methods to diagnose disease and predict outcomes for cancer patients from histopathology tissue sections. Such advances can help predict risk of recurrence, disease aggressiveness and long-term survival, according to a leading expert in the field, Professor Anant Madabhushi from Case Western…

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News • CT & ultrasound fusion

‘Virtual biopsies’ could replace tissue biopsies in the future

A new advanced computing technique using routine medical scans to enable doctors to take fewer, more accurate tumour biopsies, has been developed by cancer researchers at the University of Cambridge. This is an important step towards precision tissue sampling for cancer patients to help select the best treatment. In future the technique could even replace clinical biopsies with ‘virtual…

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Article • Glioma detection

Breakthrough liquid biopsy test to detect mutations in brain tumours

Researchers at Massachusetts General Hospital (MGH) in Boston have developed a novel blood test using an enhanced form of liquid biopsy capable of detecting the most common types of genetic mutations that occur in glioma brain tumors. The test is easy to use, inexpensive, produces results rapidly, and can be performed in most clinical laboratories. The researchers believe that the blood test has…

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News • Alternative to traditional surgery

Focused ultrasound shows promise for Parkinson’s treatment

A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinson’s disease symptoms that are much more severe on one side of the body, new research suggests. More testing is needed, but the approach, which uses a technology called focused ultrasound, could offer a new option for patients whose symptoms are poorly controlled by medications and those who cannot or do…

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News • Biopsy site markers and localization company

Hologic to acquire Somatex

Hologic, Inc. has completed the acquisition of Somatex Medical Technologies GmbH, a leader in biopsy site markers and localization technologies, for approximately $64 million. The company was previously owned by E-Med Solutions GmbH, Berlin, a group of investors led by German private equity company Westlake Partners.

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News • CARS & multiphoton microscopy

Multimodal imaging to detect cancerous cells faster and more accurately

Improving the detection of cancerous cells during surgery – this is the goal of the European research project CARMEN. The research institutes Laser Zentrum Hannover e.V. (LZH) from Germany and Multitel asbl from Belgium work together with companies from both countries, JenLab GmbH, Deltatec, and LaserSpec, to develop a novel, compact and multimodal imaging system. This could even allow the…

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News • Toxins in the gut

Connecting our microbiome to breast cancer development

A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Breast tissue cells exposed to this toxin retain a long-term memory, increasing the…

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News • Cancer research

Exploring the benefits of anticoagulants against brain metastases

Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue. To facilitate this step, cancer cells influence blood clotting, as scientists from the German Cancer Research Center and Heidelberg University Hospital have now been able to show in mice. The cancer cells actively promote the formation of clots, which helps them to arrest in the…

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News • HPV vaccines and pap smear tests

Keys to prevent many cervical cancer cases

Hundreds of thousands of cervical cancer cases per year could be prevented through widespread vaccinations for human papillomavirus (HPV) and annual pap smear tests, says an expert at a top American hospital, Cleveland Clinic, marking Cervical Cancer Awareness Month in January. Dr. Robert DeBernardo, Section Head of Gynecologic Oncology and Vice Chair Subspecialty Care for Women’s Health at…

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News • Stepstone for new treatments

Regulatory RNAs promote breast cancer metastasis

Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers. In animal experiments, the researchers could reduce the growth of metastatic tumors with a molecule designed to target that RNA and trigger its destruction. The same strategy, they say, could be used to develop a new breast cancer treatment for…

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Video • Resistance pulse

New study reveals how melanoma cells survive targeted therapies

In recent years, targeted therapies have cemented their place as some of the most important tools in cancer treatment. These medicines are designed to block specific signals that tumor cells use to grow and spread, while at the same time leaving normal cells unharmed. Targeted therapies can significantly extend patients’ lives, but the benefits are often only temporary. Over time, many cancers…

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News • Childhood cancer

Molecular super-enhancers determine progression of neuroblastomas

Childhood neuroblastomas display extreme differences in the way they develop: they can shrink spontaneously or spread aggressively to healthy tissue. It is molecular super-enhancers that activate the regulatory circuits that steer the tumor down one path or the other. These are the findings of research conducted by scientists from the Hopp Children's Cancer Center Heidelberg (KiTZ), the German…

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News • Brain rejuvenation

Drug reverses age-related mental decline within days

Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss,…

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Article • USA and Chinese experts share observations

AI in Covid research

A panel of experts from the USA and China highlighted AI use in radiological workflow during the Covid pandemic and identified current pitfalls during the Hot Topic session at RSNA 2020. Radiologists from the USA prioritised Covid articles, delivered quick reviews, made all results open access, and helped organise a white paper from the Fleischner Society recognising recommendations for the role…

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Article • Clinical decision support

AI deep learning of PET/CT images to support NSCLC treatment

A software tool to predict the most effective therapy for non-small cell lung cancer (NSCLC) developed by applying deep learning artificial intelligence (AI) to positron emission tomography/computed tomography (PET/CT) images has been developed by researchers at H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. The tool is designed to provide a noninvasive, accurate method to…

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Article • AI-assisted MRI segmentation

Deep learning boost for prostate cancer workflow

Prostate cancer radiotherapy treatments guided by MRI are increasingly being explored to help improve patient outcomes and reduce toxicities after treatment. However, this development is being held back as the MRI approach is labour intensive and requires daily adaptive treatment planning, placing significant additional demands on clinician time and oncology services. To address this, a team of…

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News • Downsized imaging

Signals from a miniature MRI unit

Magnetic resonance imaging (MRI) is indispensable in medical diagnostics. However, MRI units are large and expensive to acquire and operate. With smaller and cost-efficient systems, MRI would be more flexible and more people could benefit from the technique. Such miniature MRI units generate a much weaker signal that is difficult to analyze, though. Researchers at the Göttingen Max Planck…

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News • Success in Düsseldorf

virtual.Medica receives international resonance

For the first time in the history of MEDICA, the world-leading medical trade fair, and the industry’s number one platform for the suppliers of the medical technology industry, COMPAMED, held from 16 to 19 November 2020, took place entirely online due to the pandemic - but still won over their audiences due to their high degree of international resonance in this format too, as virtual.MEDICA and…

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Article • Profiling the coronavirus

Experts unlock Covid-19 secrets

Experts have identified two distinct immunological and cellular profiles in the lungs of Covid-19 patients which they believe could help define treatment pathways. From some of the earliest Covid-19 autopsies conducted in Europe, Swiss-based researchers have performed integrative digital pathology and transcriptomic analyses of lung tissues of 16 coronavirus patients who died from respiratory…

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News • Norwegian healthcare region

Digital pathology added to existing enterprise imaging solution

International medical imaging IT and cybersecurity company Sectra has signed a digital pathology contract with the Norwegian healthcare region Helse Vest RHF. The healthcare region already uses Sectra’s enterprise imaging solution, which will now include digital pathology. The region-wide solution allows Helse Vest to share resources among healthcare providers, and using the same system for…

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News • Block of erythrocytes formation

SARS-CoV-2 might attack red marrow

Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.

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News • Unique awareness campaign

Crafting quilts to fight pancreatic cancer

Chemistry researchers at the University of Strathclyde are aiming to raise awareness of pancreatic cancer – with the use of specially-made quilts. Fellow cancer researchers across the UK are being asked to send diagrams illustrating their work. These will then be used as the patterns for quilts made by skilled crafters. After the project is concluded, the Strathclyde researchers hope to be able…

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Article • Alternative for mammography

Breast cancer screening: Does the future belong to the abbreviated MRI?

Is mammography still the best method for breast cancer screening? For a number of breast cancers, the latest scientific findings suggest otherwise. For more than a decade, Professor Christiane Kuhl MD, Director of the Clinic for Diagnostic and Interventional Radiology at the University Hospital RWTH Aachen, has researched the use of MRI in breast cancer screening.

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Article • Mass spectrometry-based metabolomics

A new technique to understand metabolic pathways

Mass spectrometry-based metabolomics has emerged as a powerful tool to help study chemical ecology. Recent advances in the technique make it possible to study microbial interactions from complex communities. Laia Castaño-Espriu outlined the role and benefits of MS in this context in her presentation ‘Analysis of microbial ecology by mass spectrometry-based metabolomics techniques’, at the…

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News • Distant metastasis-free interval explored

High-risk breast cancers: Mode of detection is linked to patient prognosis

Breast cancers that are detected in the interval between national screening programme mammograms have a worse prognosis than those detected at the time of a screening, even if they have the same biology, according to research presented at the 12th European Breast Cancer Conference. Analysis of results from over eight years’ follow-up of the international MINDACT randomised phase III clinical…

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News • Tiny chip, huge benefits

Researchers develop the world’s smallest ultrasound detector

Researchers at Helmholtz Zentrum München and the Technical University of Munich (TUM) have developed the world’s smallest ultrasound detector. It is based on miniaturized photonic circuits on top of a silicon chip. With a size 100 times smaller than an average human hair, the new detector can visualize features that are much smaller than previously possible, leading to what is known as…

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Article • Tissue analysis

Infrared spectroscopy as a diagnostic tool

New techniques of infrared-based technology are showing strong potential for cost-effective tissue analysis. Peter Gardner, Professor of Analytical and Biomedical Spectroscopy at the University of Manchester, outlined how hyperspectral imaging coupled with sophisticated computer algorithms can identify and grade cancerous tissue, as well as offer an indication of prognosis. The technique, he…

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Article • High-capacity digital image analysis

Spatial statistics extract subvisual features

Spatial analytics offers greater clarity in the assessment of tumours beyond routine microscopic analysis. High-capacity digital image analysis enables new methods of spatial statistics to extract features not immediately distinguishable by visual inspection. These subvisual features reflect complex properties, such as intratumour heterogeneity and have the additional benefit that they can target…

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News • Breast cancer imaging

Should Gadolinium-based contrast agents be used in breast DTI?

The accuracy of breast cancer diagnosis via diffusion-tensor imaging (DTI) was equivalent both before and after the administration of a gadolinium-based contrast agent (GBCA), despite a value change in DTI parameters, finds a new research article. “However,” wrote first author Anabel M. Scaranelo of Princess Margaret Cancer Centre’s breast imaging division in Toronto, “the limitations in…

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News • G-quadruplexes

Quadruple DNA structures in breast cancer found

Four stranded DNA structures – known as G-quadruplexes – have been shown to play a role in certain types of breast cancer for the first time, providing a potential new target for personalised medicine, say scientists at the University of Cambridge. In 1953, Cambridge researchers Francis Crick and James Watson co-authored a study published in the journal Nature which showed that DNA in our…

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News • Brain tumor treatment network

'Federated learning' AI approach allows hospitals to share patient data privately

To answer medical questions that can be applied to a wide patient population, machine learning models rely on large, diverse datasets from a variety of institutions. However, health systems and hospitals are often resistant to sharing patient data, due to legal, privacy, and cultural challenges. An emerging technique called federated learning is a solution to this dilemma, according to a study…

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News • Triple-negative breast cancer

Target validation for drug development against aggressive breast cancer

At around 30.5 percent, breast cancer is the most common cancer among women in countries of the industrialized world. The number of cases has doubled since the 1980s: about 69,000 times a year women are diagnosed with breast cancer. Triple-negative breast cancer is a particularly aggressive form of breast cancer. As important receptors are missing here, treatment options and prognosis for such…

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Article • The difficulty? Unpredictability in the entire process

Immunotherapy for lung cancer patients

Better outcomes, more favourable prognoses – oncologists and their lung cancer patients didn’t dare to dream about it. Finally, there might be hope. The so-called checkpoint inhibitors (immunotherapy drug) have been used successfully, albeit not for every patient. They are a double-edged sword, with risks as well as opportunities, as explained by Professor Cornelia Schäfer-Prokop.

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Article • Goodbye to grayscale

Dual Energy CT – seeing x-rays with colors

Computed tomography (CT) is one of the most important imaging options for the diagnostics of patients. For a long time, in clinical routine CT technology mostly showed the Hounsfield Units (HU) that are indicated in the grayscale. However, the Dual Energy CT (DECT) enables colored X-ray images, therefore significantly improving examination methods. “We can also do material separation and get a…

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Article • More than the sum of their parts

The benefits offered by hybrid imaging

Former ESR President Katrine Riklund will explore the clinical applications of hybrid imaging in a virtual session for the European Congress of Radiology 2020. She will discuss a number of common indications of hybrid imaging in areas of oncological diagnosis, the indications and limitations of hybrid imaging in common diseases, and the added value of hybrid imaging. “The major benefit of…

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News • Hidden in our genes

scHOT: Discovering the fate of cell development

As cells develop, changes in how our genes interact determines their fate. Differences in these genetic interactions can make our cells robust to infection from viruses or make it possible for our immune cells to kill cancerous ones. Understanding how these gene associations work across the development of human tissue and organs is important for the creation of medical treatments for complex…

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News • Neurodegeneration research

Developing a rapid drug-testing platform for Alzheimer’s

A gene has been discovered that can naturally suppress the signs of Alzheimer’s Disease in human brain cells, in research led by Queen Mary University of London. The scientists have also developed a new rapid drug-screening system for treatments that could potentially delay or prevent the disease. The main challenge in testing Alzheimer’s drugs in clinical trials is that participants need to…

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News • Lesion segregation

Explaining the extreme complexity of mutations in tumor genomes

Scientists from the German Cancer Research Center (DKFZ) and the Universities of Cambridge and Edinburgh have been studying the evolution of tumors following chemical damage. They discovered that the DNA lesions caused by the chemical are not eliminated immediately, but are passed on unrepaired over several rounds of cell division. This "lesion segregation" can drive unexpectedly…

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Article • Magnetic pull on catheters

Fringe Field Navigation transforms endovascular surgery

A new technique could enable vascular surgeons to reach even the more difficult body regions. Instead of pushing catheters into minute veins, the system, devised in Canada by Professor Sylvain Martel and team at the Polytechnique Montréal Nanorobotics Laboratory, uses magnetic forces to pull a guidewire, or catheter, into remote physical locations, guiding medical instruments into narrow and…

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News • Cancer research

Lymph node analysis to hunt down metastases

What makes tumor cells turn murderous? The Fraunhofer Institute for Toxicology and Experimental Medicine ITEM is investigating the mechanisms of metastasis formation – and searching for approaches for new treatments in the fight against cancer. Among other things, the research team at Fraunhofer ITEM has developed a method that enables them to analyze entire lymph nodes.

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News • From physical to computational staining

Deep learning accurately stains digital biopsy H&E slides

Tissue biopsy slides stained using hematoxylin and eosin (H&E) dyes are a cornerstone of histopathology, especially for pathologists needing to diagnose and determine the stage of cancers. A research team led by MIT scientists at the Media Lab, in collaboration with clinicians at Stanford University School of Medicine and Harvard Medical School, now shows that digital scans of these biopsy…

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News • Two-way magnetic resonance tuning

New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis, offers a significant advance in using magnetic resonance imaging (MRI) to pick out even very small tumors from normal tissue. The work is published in the journal Nature Nanotechnology. Chemical probes that produce a signal on MRI can be used to…

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News • Robotic innovation

Micro robot rolls deep into the body

A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell travelling through the circulatory system. It has the shape, the size and the moving capabilities of leukocytes and could perhaps be well on its way – in a rolling motion of course – to revolutionize the minimally invasive treatment of…

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News • Better tissue discrimination, lower radioation dose

Improving image quality of CT scans

Computed tomography (CT) is one of the most effective medical tests for analysing the effects of many illnesses, including COVID-19, on the lungs. An international team led by the Universitat Oberta de Catalunya (UOC) has developed a new method that improves the quality of the images obtained from CT scans. The algorithm, which has been tested on simulated data, enables them to distinguish…

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News • Utilizing findings from cancer research

Understanding immunity to SARS-CoV-2

Why does every person react differently to an infection with the coronavirus SARS-CoV-2? Why do some people have no symptoms or only mild symptoms of COVID-19, the disease which it causes? And why do some people become so severely ill that they require ventilators or even die? These questions are being investigated by Professor Mascha Binder, director of the Department of Internal Medicine IV at…

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Article • A more integrative approach to digital pathology

imCMS: The door to simple, cheap, reliable bio-stratification

Bringing molecular and digital pathology closer together through a more integrative approach can lead to clear advantages for diagnostic and research workflows. During the recent Digital Pathology and AI Congress (London), Professor Viktor Koelzer explored the benefits and paid particular attention to colorectal cancer (CRC).

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News • Pediatric cancer imaging

DW MRI measures tumor chemotherapy response with less radiation

Whole body diffusion-weighted magnetic resonance imaging (DW MRI) may aid in the assessment of cancer treatment response in children and youth at much lower levels of radiation than current approaches, suggests a small study funded by the National Institutes of Health. The results appear in Radiology. Researchers compared DW MRI, which measures the density of tumors by tracking the movement of…

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News • Cause for lack of immune defense against tumors discovered

Improving immunotherapy for cancer

Our immune system not only protects us against infection, but also against cancer. This powerful protection is based in particular on the activation of special cells of the immune system, CD8+ T cells. These cells recognize infected or cancer cells and kill them specifically. “The ability of the immune system and especially CD8+ T cells to eliminate cancer cells in tissues such as the lung, gut…

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News • A novel method

Precise delivery of of therapeutics into the body

A new way to deliver therapeutic proteins inside the body uses an acoustically sensitive carrier to encapsulate the proteins and ultrasound to image and guide the package to the exact location required, according to Penn State researchers.

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Article • Tools for practitioners

Computational pathology: Heading for personalised medicine

Computational pathology has increased applications for diagnosis, prediction of prognosis and therapy response, facilitating the movement of healthcare towards personalised medicine. Coupled with deep learning, such tools are ever more efficient and robust within research and clinical settings. The growing role of computational pathology was highlighted by Professor Andrew Janowczyk at the…

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News • Medulloblastoma

New insights into deadly brain tumours in children

The causes of 40 percent of all cases of certain medulloblastoma – dangerous brain tumors affecting children – are hereditary. A genetic defect that occurs in 15 percent of these children plays a key role by destabilizing the production and breakdown of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer.

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News • Oncology breakthrough

Blood test detects 50+ cancer types, often before symptoms show

Researchers have developed the first blood test that can accurately detect more than 50 types of cancer and identify in which tissue the cancer originated, often before there are any clinical signs or symptoms of the disease. In a paper published in the leading cancer journal Annals of Oncology, the researchers show that the test, which could eventually be used in national cancer screening…

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Article • Coronavirus disease research

Seeking a COVID-19 antidote: the potential of ACE2

As coronavirus disease COVID-19 continues to jet and alight invisibly around the globe, scientists now report that the virus has mutated to become two strains: the older ‘S-type’ appears milder and less infectious, while the later-emerging ‘L-type’, is more aggressive, spreads more quickly, and currently accounts for about 70 per cent of cases. Worldwide, medical researchers are exploring…

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News • Enhancing cancer imaging

New contrast agent for early diagnosis of brain metastases

A group of researchers led by Leif Schröder from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent. To this end, the team uses a synthetic molecule that helps to detect the formation of new blood vessels, producing much more sophisticated…

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News • Smart algorithm

Automated analysis of whole brain vasculature

Diseases of the brain are often associated with typical vascular changes. Now, scientists at LMU University Hospital Munich, Helmholtz Research Centre for Environmental Health and the Technical University of Munich (TUM) have come up with a technique for visualising the structures of all the brain's blood vessels – right down to the finest capillaries – including any pathological changes. So…

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News • "SOLUS" imaging project

Breast screening breakthrough to end unnecessary biopsies

Scientists from the project SOLUS (Smart optical and ultrasound diagnostics of breast cancer) under the EU funding framework programme Horizon2020 have developed a non-invasive, multi-modal, imaging system that uses ultrasound and light technologies to easily differentiate between benign or malignant lesions – without having to perform a biopsy. Similar to a pregnancy ultrasound appointment, a…

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News • Surprising discovery

Fatty liver disease can also affect lean people

Non-alcoholic fatty liver disease (NAFLD) is mostly diagnosed in overweight and obese people. However, severe forms of NAFLD can also be detected in rare genetic diseases such as lipodystrophy or in patients with HIV, putting them at a high risk for developing liver failure, diabetes and cardiovascular diseases. Norbert Stefan and colleagues have now detected a yet unknown cause of NAFLD in lean…

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News • Finding new treatment options

Cancer cachexia: Help against muscle loss

Cancer cachexia often occurs in cancer patients in an advanced state. This metabolic wasting syndrome leads to severely reduced muscle mass and fat tissue, which cannot be reversed by nutritional support. Furthermore, muscle regeneration is affected during cancer cachexia due to impaired muscle stem cell function. A problem that also occurs often in the aging process. Cancer cachexia is…

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News • Promising treatment target

"Partner-in-crime" of colorectal cancer discovered

A protein that helps colorectal cancer cells spread to other parts of the body could be an effective treatment target, researchers from Hokkaido University discovered. Colorectal cancer patients with an immune system-regulating protein called interleukin 6 (IL-6) are more likely to have recurring tumors that can also spread to the liver, according to research published in the journal Cancer…

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Article • X-Nuclei MRI

Oxygen provides insights into tumour metabolism

Magnetic resonance imaging (MRI) usually measures the magnetic moment of the hydrogen atomic nuclei arising from the spin. However, scientists at the German Cancer Research Centre (DKFZ) are investigating the spin of other nuclei for imaging: ‘X-nuclei imaging has a large potential for MRI imaging as the x-nuclei play an important part in many physiological processes,’ according to doctor and…

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News • Zooming in

Breast cancer map reveals how mutations shape the tumour landscape

Scientists have created one of the most detailed maps of breast cancer ever achieved, revealing how genetic changes shape the physical tumour landscape. An international team of scientists, brought together by a £20 million Grand Challenge award from Cancer Research UK, has developed intricate maps of breast tumour samples, with a resolution smaller than a single cell. These maps show how the…

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News • Cancer radiotherapy monitoring

Novel hydrogel turns pink to indicate radiation dose sweet spot

More than half of all cancer patients undergo radiation therapy and the dose is critical. Too much and the surrounding tissue gets damaged, too little and the cancer cells survive. Subhadeep Dutta and Karthik Pushpavanam, graduate students working in the lab of Kaushal Rege, Professor at Arizona State University in Tempe, and collaborators at Banner-M.D. Anderson in Gilbert, Arizona, developed a…

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News • Triple-negative forms impeded

Scientists stop breast cancer cells from spreading in the lab

Biologists have discovered a way to stop cells from one of the most aggressive types of breast cancer spreading in the lab. The study points towards new avenues of research to combat the devastating disease. The results of the study of Triple-Negative Breast Cancer by the team from the Universities of Manchester, Glasgow and Sheffield and funded by Breast Cancer Now are published in Oncogene.…

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News • After mastectomy

Promising approach for breast regeneration

A team of researchers from Osaka University, Kyoto Prefectural University of Medicine, and Toppan Printing Co., Ltd. succeeded in reconstructing adipose tissue balls (“mini-breasts”) with a functional vascular network using patient-derived cells, achieving a high graft survival rate in small animal models. So far, silicone breast implants were primarily used in breast reconstruction following…

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News • Updating treatments

Sugar and fat can make cancer cells harder to kill

In their quest to find new and better methods to make cancer cells more susceptible to treatment, Karin Lindkvist and her research group at Lund University in Sweden are looking into the world of molecules, using the X-rays at the MAX IV laboratory. The researchers believe that limiting the cells' access to sugar will make cancer cells more sensitive to treatment. Many of the cancer treatments…

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Article • Underrated technique

Pitfalls in pelvic CT imaging

Computed tomography (CT) plays an increasingly important role in assessing pelvic disease, particularly when patients present with acute abdominal pain. In addition, radiomic approaches on CT are being developed to increase the characterisation of ovarian cancer for optimising treatment planning.

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News • Digitizing workflows

Dutch hospital expands imaging solution to include digital pathology

Medical imaging IT and cybersecurity company Sectra has signed a digital pathology contract with the Dutch hospital Zuyderland MC. A digital pathology workflow makes it possible to access and share images and information between departments and hospitals. Storing, reviewing and sharing digital pathology images increases efficiency in primary diagnostics and improves cancer care by facilitating…

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News • Hyperventilation vs cardiac arrhythmia

Hold your breath – save your heart?

A technique that enables patients suffering from heart conditions to hold their breath safely for over 5 minutes could have potential as part of a new treatment for cardiac arrhythmias, say researchers at the University of Birmingham. In a new study, published in Frontiers in Physiology, researchers initially proposed the technique as a new means for earlier diagnosis of ischaemic heart disease.…

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News • Personalized treatment

Could B cells turn the tide in sarcoma immunotherapy?

How can the treatment of soft tissue sarcomas, these particularly resistant and aggressive forms of cancer, be improved and better personalized? An international team led by Wolf Hervé Fridman with researchers from Inserm, Sorbonne Université and Université de Paris at the Cordeliers Research Center, in collaboration with the French League against cancer and Institut Bergonié, has shown that…

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News • Tumour Matrisome Index (TMI)

Big data breakthrough in cancer diagnosis

A team of researchers from the National University of Singapore (NUS) has discovered a new personalised tool to detect cancer, predict patient survivability and how well a cancer patient would respond to immunotherapy. This tool is a specially-designed cancer 'scorecard' to be used with the standard blood test for cancer (also known as liquid biopsy). This 'scorecard', which the team termed as…

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News • MRI & machine learning

A look into the genome of brain tumors

Researchers at Osaka University have developed a computer method that uses magnetic resonance imaging (MRI) and machine learning to rapidly forecast genetic mutations in glioma tumors, which occur in the brain or spine. The work may help glioma patients to receive more suitable treatment faster, giving better outcomes. The research was recently published in Scientific Reports. Cancer treatment…

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News • Gastric squamous-columnar junction cancer

The role of stem cells in deadly gastric SCJ cancer

A study led by scientists from Cornell University provides important new insights into a common and deadly type of gastric cancer. Incidence of this cancer, called gastric squamous-columnar junction (SCJ) cancer, also known as gastroesophageal cancer, rose 2.5 times in the United States between the 1970s and 2000s, while cases of all gastric cancers have decreased by more than 80% since the…

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Sponsored • The Heraeus Symposium at DKOU

Challenges of periprosthetic infection

Periprosthetic joint infection (PJI) is on the increase internationally. In Germany, for example, around 14,500 cases of PJI in hip and knee replacements occur annually. 5,100 of those are caused by multidrug resistant pathogens. ‘Eighty-seven percent of those affected die within five years,’ orthopaedic surgeon Professor Rudolf Ascherl MD pointed out during the Heraeus Symposium held at the…

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News • Stimulated Raman histology

Imaging system and AI algorithm accurately identify brain tumors

A novel method of combining advanced optical imaging with an artificial intelligence algorithm produces accurate, real-time intraoperative diagnosis of brain tumors, a new study finds. Published in Nature Medicine, the study examined the diagnostic accuracy of brain tumor image classification through machine learning, compared with the accuracy of pathologist interpretation of conventional…

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News • DeepMind to help human radiologists

Google-powered AI spots breast cancer

A computer algorithm has been shown to be as effective as human radiologists in spotting breast cancer from x-ray images. The international team behind the study, which includes researchers from Google Health, DeepMind, Imperial College London, the NHS and Northwestern University in the US, designed and trained an artificial intelligence (AI) model on mammography images from almost 29,000 women.…

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Article • WB-MRI vs. prostate cancer

Whole-body MRI improves disease evaluation

Whole-body magnetic resonance imaging (WB-MRI) is championed as offering significant benefits, such as improving disease evaluation for prostate cancer patients. During an intense session in genito-urinary cancer at ECR 2019, three key speakers focused on the advantages over conventional imaging modalities as well as discussing new PET (Positron Emission Tomography) tracers.

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Article • TMAs in digital pathology

Infusing tissue micro­arrays with new, 'digital' life

The advent of digital pathology is helping to address some of the challenges surrounding tissue microarrays as they are integrated into the digital workflow, in some ways giving them ‘a new lease of life’, according to Professor Inti Zlobec, who spoke at the Digital Pathology and AI Congress in London last December. As Head of the Translational Research Unit at the Institute of Pathology,…

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News • Detailed map of immune cells

The Human Blood Atlas: a mighty new tool to fight deadly diseases

A first-ever map of the human body’s immune cells has been created by scientists at SciLifeLab, providing medical research with a detailed description of the proteins in human blood. The open-access database offers medical researchers an unprecedented resource in the search for treatments for diseases. Published in the journal Science, the Blood Atlas resource is the latest database to be…

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News • Multiple myeloma therapy

Finding a formula for blood cancer vaccine

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December. This is the first study to experimentally determine which…

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Article • The future has begun

Cancer care 2035: multi-disciplinarity is key

An enthralling insight into the care that could be offered to cancer patients of the future was presented by cancer imaging expert Professor Regina Beets-Tan during her a keynote presentation at the recent British Institute of Radiology congress. In the session ‘Oncologic imaging: Future perspectives’, the professor outlined what a Multi-Disciplinary Team (MDT) of the future – a team in…

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News • Early detection of colon cancer

When is the right time for the follow-up colonoscopy?

For the early detection of colorectal cancer, patients with statutory health insurance are entitled to two colonoscopies. If the first examination does not reveal any abnormal findings, a follow-up after a period of ten years is recommended. Scientists at the German Cancer Research Center are now systematically investigating when and how often tissue lesions are detected during the follow up…

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News • Single cell analysis & machine learning

scPred: Finding the ‘fingerprint’ of human cells

Researchers say a new method to analyse data from individual human cells could be a step-change for diagnosing some of the most devastating diseases, including cancer and autoimmune disease. By combining single cell analysis techniques with machine learning algorithms, a team led by researchers at the Garvan Institute of Medical Research has developed a method to ‘fingerprint’ human cells.…

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Video • Exposing the enemy

New algorithm detects even the smallest cancer metastases

Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases at the level of single disseminated cancer cells in whole mice. Cancer is one of the leading causes of death worldwide. More than 90% of cancer patients die of distal metastases rather than as a direct result of the primary…

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News • Grant for AI and genomic analysis

AI help for better diagnosis and treatment of prostate cancer

Prostate cancer is the second cause of cancer-related death in men. Currently, its diagnosis occurs via imaging and must be confirmed by biopsy. Simona Turco from the Eindhoven University of Technology (TU/e) wants to improve prostate cancer diagnosis by using machine learning algorithms to localize tumors and thereby replace entirely the necessity for biopsies. Besides, by combining this with…

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News • Non-alcoholic fatty liver disease

3D model of human liver tissue for better NAFLD diagnosis

Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disorder in developed countries. Histological analysis of liver tissue is the only widely accepted test for diagnosing and distinguishing different stages of NAFLD. However, this technique provides only two-dimensional images of the liver tissue in low resolution and overlooks potentially important 3D structural…

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News • Promising lab tests

Using photoacoustics for breast imaging

A new, portable breast imaging system under development in Buffalo has the potential to better identify breast cancer in women with dense breast tissue. That is among the findings of a study published in the journal IEEE Transactions on Biomedical Engineering. The study was led by University at Buffalo researchers in collaboration with Roswell Park Comprehensive Cancer Center and Windsong…

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News • Long-term placement in breast lesions

CE Mark for implantable RFID tag extended

Hologic announced the extension of the CE Mark for its LOCalizer radiofrequency identification (RFID) tag for long-term placement. The tag can now be implanted more than 30 days prior to a breast-conserving surgery, providing even greater flexibility and convenience to patients and providers. The LOCalizer wire-free guidance system is a non-radioactive, radiofrequency localization system designed…

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Interview • The search is on

MRI contrast agents: Aiming to work without radioactivity

MRI is now indispensable for diagnosing diseases and monitoring therapies. However, the ongoing discussion on gadolinium deposits in the brain has intensified the search for alternatives. Dr Daniel Paech of the German Cancer Research Centre in Heidelberg, Germany, discussed potential solutions to acquire high-quality images without contrast agents.

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News • Malignant infantile brain tumours

​Epilepsy drug inhibits brain tumour development

Medication prescribed for a certain type of epilepsy may offer a new method for treating malignant infantile brain tumours. A specific mTOR inhibitor has the ability to cross the blood–brain barrier to both reach and attack the tumour at source. This has been demonstrated by researchers from Uppsala University, in collaboration with US and UK colleagues, whose research has now been published in…

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News • Nanoswarm

Tiny transporters deliver treatment to stroke patients

Swarms of nanoparticles which are 15,000 times smaller than a pinhead may be able to deliver vital drugs to the brain, offering new hope to patients in the early stages of a stroke. The research, carried out at The University of Manchester, shows that tiny vesicles called liposomes, just 100 nanometres in diameter can translocate through the damaged blood brain barrier following stroke. And that…

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Article • Growing brain tumours in a petri dish

3D organoids for glioblastoma patients

Research that might lead to new treatment options and longer survival for patients with glioblastoma – a malignant and particularly invasive type of brain tumour – is ongoing at ZHT, the Centre for Brain Tumours, and the Wilhelm Sander Neuro-oncology Treatment Unit at University Hospital Regensburg, which form one of the largest and most modern facilities for brain tumour treatment in…

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News • Surgical breakthrough in France

Robot enables lumbar spine repair

Is it possible to repair the rachis without having to open the abdomen or the back? A team of French surgeons has done just that. Thanks to minimally invasive robotic surgery, exposing the patient to risky spine interventions may soon be avoidable, a leading surgeon explained. The team of neurosurgeons and vascular surgeons has, for the first time, successfully repaired the lumbar spine with the…

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Article • Good for some, not all

Robotic surgery: Myths and misconceptions

The first use of a robot-supported surgical intervention was reported in 1985, when the robot arm PUMA 560 placed a needle for a cerebral biopsy using CT guidance. Since then, strong growth in the market for robotic surgery has occurred, due to an increasing automation demand in the healthcare as a whole and greater concentration on minimally invasive surgery (MIS) for faster recovery.…

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Video • Cancerous construction

Blocking the path of cancer ‘super-highways’

A key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread, has been identified by researchers at the Francis Crick Institute. The two studies, published in Nature Materials and PLOS Computational Biology, explain the mechanism that causes changes in the structure of tissues. Using experimental and computational biology, the…

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News • Targeted therapy for pancreatic carcinoma

Hitting cancer with 'homing' radioactive molecules

Pancreatic cancer is one of the leading causes of cancer‑related deaths worldwide. Patients with pancreatic cancer often receive chemotherapy or radiation therapy, which are not always effective and can have toxic side effects. In a collaborative research between Osaka University and the University of Heidelberg, researchers are exploring a new method of treatment that brings powerful yet…

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News • Danger in the womb

Xenoestrogens in the womb: a burden for babies

Early childhood life in the womb is particularly sensitive to the effects of environmental pollutants. A team from Empa and the University of Vienna has now for the first time been able to show how a pollutant from contaminated food – the environmental estrogen zearalenone – spreads in the womb and is metabolized into harmful metabolites. Xenoestrogens are absorbed through the environment,…

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News • When painkillers won't help

A new approach to pancreas pain treatment

One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the…

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News • Tiny biomaterials

On the way to safer nanomedicine

Tiny particles that can fight cancer or that can easily pass through any interface within our body are a great promise for medicine. But there is little knowledge thus far about what exactly will happen to nanoparticles within our tissues and whether or not they can cause disease by themselves. Within an international research consortium, Empa scientists have now developed guidelines that should…

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News • Better image quality with fewer sensors

Machine learning improves biomedical imaging

Scientists at ETH Zurich and the University of Zurich have used machine learning methods to improve optoacoustic imaging. This relatively young medical imaging technique can be used for applications such as visualizing blood vessels, studying brain activity, characterizing skin lesions and diagnosing breast cancer. However, quality of the rendered images is very dependent on the number and…

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News • A STAMP with high value

New tech makes biopsies less invasive, more informative

A team of researchers has developed a novel technology that could sensitively and accurately detect and classify cancer cells, as well as determine the disease aggressiveness from the least invasive biopsies. With this new technology called STAMP (Sequence-Topology Assembly for Multiplexed Profiling), comprehensive disease information can be obtained faster, at a much earlier stage of the…

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Article • Cancer of unknown primary

CUP: in search for the smoking gun

Cancer of unknown primary (CUP) can send radiologists on a frustrating scavenger hunt: metastases were detected but the primary cancer is nowhere to be seen. Professor Alwin Krämer, Head of the Clinical Cooperation Unit Molecular Haematology/Oncology at University Hospital Heidelberg and the German Cancer Research Center, explains strategies for dealing with CUP.

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News • CRISPR-Cas vs MDC1A

Undoing the damage of muscle dystrophy

A new technology has brought researchers one step closer to a future cure for Congenital Muscular Dystrophy type1A, a devastating muscle disease that affects children. The new findings are based on research by Kinga Gawlik at Lund University, Department of Experimental Medical Science, and were recently published in Nature. Congenital Muscular Dystrophy type1A, MDC1A, a progressive genetic…

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News • Feasibility study

Liquid biopsy to complement early breast cancer screening

Investigators from the Biomedical Research Institute of Malaga [(IBIMA)-CIMES-UMA, Malaga Spain] and collaborators have published the first pilot study to examine the use of a non-invasive liquid biopsy in early diagnosis of breast cancer. This study was unique in that the ctDNA analyses was performed before any invasive diagnostic procedure or treatment. To achieve their goal, the researchers…

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News • Methylation of microRNA

Is it cancer? New method could tell the difference

Levels of molecules associated with genetic function, such as microRNA, can be an important indicator of abnormal activity associated with cancer. However, little is known about how different molecules are altered in cancerous cells. Now, researchers from Japan have found a new way of distinguishing cancerous from non-cancerous tissues. In a study published in Nature Communications, researchers…

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Article • Methods, quality assurance, commercial providers issues

Molecular testing takes a huge leap

In terms of success in revolutionary cancer treatment, molecular genetic examination procedures have developed immensely over recent years. They now range from conventional polymerase chain reactions (PCR) or fluorescence-in-situ hybridisation (FISH) to Next Generation Sequencing (NGS) with analysis of the entire exome or genome (Whole-Exome, WES or Whole-Genome, WGS) and of the transcriptome…

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News • Genetic mutations

'Invade and evade': Deciphering pancreatic cancer’s tactics

Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies. Mutations in the genes KRAS and TP53 are closely linked to pancreatic ductal adenocarcinoma, by far the most common type of pancreatic cancer.…

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News • Watching the change

Predicting cancer risk with computational electrodynamics

Researchers from Northwestern University are using Argonne supercomputers to advance the development of an optical microscopy technique that can predict and quantify cancer risks at extremely early stages. The basic principle driving Allen Taflove’s computational electrodynamics research — which bears the potential to transform how we diagnose, and possibly treat, various forms of cancer —…

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Article • Multiscale integrative cross-disciplinary imaging

Linking pathology and radiology workflows

Pathologic-radiologic correlation is already utilised in various settings as a tool to assess the interpretive performance of imaging studies and identify radiologic features corresponding to histologic findings. However, correlative assessment is currently limited mainly to the fields of research and quality assurance, and is generally not a routine element of the radiologist or pathologist…

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Article • Seeking the right questions

Developing algorithms to assist routine pathology

Artificial Intelligence (AI) is destined for a significant role in assessing histology data but the key to developing the necessary algorithms lies in data quality – rather than the quantity, according to Professor Jens Rittscher. He also warns that we are some distance from seeing AI replacing human pathologists in this scenario, primarily because presently the risks of automated…

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Article • Personalized medicine

Exploring the potential of High-Content Screening

The key challenges and opportunities surrounding High-Content Screening have been outlined in a presentation to leading scientists and technologists at a major lab conference. Speaking at the recent SLASEurope 2019 event in Barcelona, Professor Matthias Nees from the Institute of Biomedicine in the Department of Biology at the University of Turku, Finland, outlined the potential of High-Content…

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News • Dose reduction

Increasing precision for radiotherapy

A new way of concentrating radiotherapy dose in tumours, while minimising damage to healthy cells, has been proposed in research led by scientists at the University of Strathclyde. The study proposes that focusing high-energy particle beams on a small spot deep inside the body could potentially enable clinicians to target cancerous tumours precisely, while reducing the dose to surrounding tissue.…

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Video • Nuclear magnetic resonance relaxometry

Hydration sensor could improve dialysis

For patients with kidney failure who need dialysis, removing fluid at the correct rate and stopping at the right time is critical. This typically requires guessing how much water to remove and carefully monitoring the patient for sudden drops in blood pressure. Currently there is no reliable, easy way to measure hydration levels in these patients, who number around half a million in the United…

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Video • Drug delivery, microsurgery

Microbots show promise in tumor treatment

Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast. But often what ails us is inside the body and is not so easy to reach. In such cases, a treatment like surgery or chemotherapy might be called for. A pair of researchers in Caltech's Division of Engineering and…

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News • Cellular interactions

Repairing aged tissue by messing with the neighbors

Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce…

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News • "Bless you!"

Common cold virus could revolutionise bladder cancer treatment

A strain of the common cold virus has been found to potentially target, infect and destroy cancer cells in patients with bladder cancer. No trace of the cancer was found in one patient following treatment with the virus. The researchers published their findings in the medical journal Clinical Cancer Research. Researchers from the University of Surrey and Royal Surrey County Hospital investigated…

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News • Oncology

Response to gene-targeted drugs depends on cancer type

Cancers with the same genetic weaknesses respond differently to targeted drugs depending on the tumour type of the patient, new research reveals. The study is set to prompt changes in thinking around precision medicine—because it shows that the genetics of a patient's cancer may not always be enough to tell whether it will respond to a treatment. The researchers are already starting to design…

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Video • Photonics

Rapid tissue analysis: Laser light detects tumors

Cancer - this diagnosis affects almost every second German at some point in his life. It is the second most frequent cause of death in Germany. But the earlier the disease is diagnosed, the greater are the chances of surviving it. A team of researchers from Jena present a groundbreaking new method for the rapid, gentle and reliable detection of tumors with laser light at the leading trade fair…

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News • Oncology

Anti-inflammation approach shows promise for preventing cancer metastasis

An anti-inflammatory drug called ketorolac, given before surgery, can promote long-term survival in animal models of cancer metastasis, a team of scientists has found. Furthermore, so-called "pro-resolution" therapies can also trigger the immune system to eliminate metastatic cells. The research also suggests that flanking chemotherapy with anti-inflammatory drugs can unleash anti-tumor…

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Article • Urothelial carcinoma

AI assists in PD-L1 scoring

A new deep learning algorithm, which demonstrates the potential of artificial Intelligence (AI) to support pathologists, has been developed for PD-L1 scoring in tumour cells and immune cells in urothelial carcinoma samples. Speaking at the Digital Pathology and Artificial Intelligence Congress in London last December, Dr Michel Vandenberghe, from AstraZeneca, outlined how PD-L1 expression level…

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News • Microsatellites

Stomach and colorectal cancer: AI identifyies patients for immunotherapy

Changes in certain sections of the genetic material of cancer cells, so-called microsatellites, can provide an important indication of whether immunotherapy may be successful in a patient with stomach or colorectal cancer. Scientists from Uniklinik RWTH Aachen, the German Cancer Research Center (DKFZ), the German Cancer Consortium (DKTK) and the National Center for Tumor Diseases Heidelberg (NCT)…

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News • Oncology

Killing the unkillable cancer cells

We all know someone affected by the battle against cancer. And we know that treatments can be quite efficient at shrinking the tumor but too often, they can’t kill all the cells, and so it may come back. With some aggressive types of cancer, the problem is so great that there is very little that can be done for the patients.

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Article • Artificial Intelligence

Allying AI to biomarkers is powerful but validation remains challenging

Using artificial intelligence (AI) to push development of imaging biomarkers shows great promise to improve disease understanding. This alliance could be a game changer in healthcare but, to advance research, clinical validation and variability of results must be factored in, a prominent Spanish radiologist advises. In clinical practice efforts are already ongoing to apply AI to obtain new…

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News • Blood cancer

Mapping bone-marrow microenvironment sheds fresh light on leukaemia

Stem cells are surrounded and protected by the stem-cell niche – the microenvironment – of the tissue in which they are found. Researchers at Karolinska Institutet have mapped the stem-cell niche in the bone marrow of mice and studied how it is influenced by developing leukemia. Their results, which are published in the journal Cell, show that the bone-marrow microenvironment is more complex…

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News • Common DNA structure

Nano-signature discovery could revolutionise cancer diagnosis

A quick and easy test to detect cancer from blood or biopsy tissue could eventually result in a new approach to patient diagnosis. The test has been developed by University of Queensland researchers Dr Abu Sina, Dr Laura Carrascosa and Professor Matt Trau, who have discovered a unique DNA nanostructure that appears to be common to all cancers. Cancer is an extremely complicated and variable…

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News • New discovery

Cancer drugs promote stem cell properties of colorectal cancer

Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many…

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News • Nanotechnology

Targeting cancer cells with gold nanorods

Scientists at the University of Birmingham are working with a Canadian tech company to investigate whether gold nanorods can be used to target cancer cells in the human body. They have joined experts at Sona Nanotech Inc. to develop the next generation of nanorods for tissue imaging. The team will work with its Canadian partners - beginning by creating luminescent nanorods by transforming gold…

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News • New study

Ribosome inhibition may hold the key to multi-stage cancer treatment

Nearly 90% of all cancer patient deaths are due to metastasis. A study from Uppsala University shows that a process that allows the cells to metastasise is aided by the synthesis of new ribosomes, the cell components in which proteins are produced. The results open the possibility for new treatment strategies for advanced cancers. The study is published in Nature Communications. As tumours…

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News • Ten-year trial results

Radiotherapy reduces recurrence of early, hormone-driven breast cancer

Women with early, low risk, hormone-driven breast cancer are less likely to have a recurrence of their disease if they have radiotherapy after surgery, as well as anti-hormone treatment, according to results from a trial that has followed 869 women for ten years. New findings from the 8 A trial of the Austrian Breast and Colorectal Cancer Study Group (ABCSG), presented at the ESTRO 38 conference,…

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Article • Mass spectrometry in patient care

LC-MS/MS: Why qualitatively high-value analysis is cheaper in the end

In the past, we repeatedly focused our attention on developments in the clinical application of mass spectrometry-based methods in patient care. Various aspects became significant. Today, the use of Liquid Chromatography Triple Quad Mass Spectrometry (LC-MS/MS) for therapeutic drug monitoring (TDM) can be considered today’s standard, although classically applied immunoassays continue to be…

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News • Prototype

This new, cheaper endoscope could redefine cancer screening

Engineers have developed a prototype endoscope which they say could cut the cost of manufacture from £80,000 to just £40. The redesigned device has the potential to revolutionise cancer screening in low-to-middle income countries where the cost of equipment makes screening prohibitively expensive. The endoscope is designed to see inside the upper part of the digestive tract for signs of…

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News • Personalized medicine

FDA approves first targeted therapy for metastatic bladder cancer

The U.S. Food and Drug Administration (FDA) granted accelerated approval to Balversa (erdafitinib), a treatment for adult patients with locally advanced or metastatic bladder cancer that has a type of susceptible genetic alteration known as FGFR3 or FGFR2, and that has progressed during or following prior platinum-containing chemotherapy. Patients should be selected for therapy with Balversa…

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News • Rare bone cancer

Targeted approach to therapy for chordomas

Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of chordomas in advanced stages after conducting gene analysis. Their findings, published in the journal Nature…

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News • Tumor-associated macrophages

Immune cells key to predicting cancer outcomes

Scientists have identified key changes in immune cells within cancerous tumours that could help improve the development of treatments. The study, which has been published in the journal Cancer Cell, also found a set of genes that are expressed at high levels in breast cancer tumours and linked to more aggressive cancer types. Researchers say the discoveries offer clues to diagnosis and predicting…

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Video • Cyberattack

Hackers can manipulate cancer scans

​Hackers can access a patient's 3-D medical scans to add or remove images of malignant tumors, thus placing patients at risk of misdiagnoses. The new study, published by Ben-Gurion University of the Negev cybersecurity researchers, showed that the altered scans successfully deceived both radiologists and artificial intelligence algorithms used to aid diagnosis. ​A 3-D CT (computerized…

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News • Cancer research

Black nanoparticles slow tumor growth

Melanin protects our skin from the sun’s damaging rays by absorbing light energy and converting it to heat. This could make it a very effective tool in tumor diagnosis and treatment, as demonstrated by a team from the Technical University of Munich (TUM) and Helmholtz Zentrum München. The scientists managed to create melanin-loaded cell membrane derived nanoparticles, which improved tumor…

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Article • Meeting of the generations

We need a Senior Laboratory

It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results.

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News • Thrombocytes

Blocking platelets could prevent fatty liver disease and liver cancer

Non-alcoholic fatty liver disease is among the most common chronic hepatic disorders in Western industrial countries and the rate is also rapidly rising in newly industrialized countries. Experts estimate that about 30 to 40 percent of the population worldwide develop this liver condition. In the United States, this disease is well on the way to becoming the most frequent indication for liver…

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News • Breast healthcare

FDA advances landmark policy changes to modernize mammography services

The U.S. Food and Drug Administration (FDA) announced important new steps to modernize breast cancer screening and help empower patients with more information when they are considering important decisions regarding their breast health care. For the first time in more than 20 years of regulating mammography facilities, the agency is proposing amendments to key regulations that would help improve…

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News • Idiopathic pulmonary fibrosis

Protein linked to cancer growth drives deadly lung disease IPF

A protein associated with cancer growth appears to drive the deadly lung disease known as idiopathic pulmonary fibrosis (IPF), according to new research from Cedars-Sinai. The discovery, made in laboratory mice and human tissue samples, may have implications for treating the disease using existing anti-cancer therapies that inhibit the protein PD-L1. Idiopathic pulmonary fibrosis is a chronic,…

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Article • PET/MRI, PET/RF & more

Disruptive innovations in molecular imaging

Molecular imaging is an exciting field for scientists who are willing to explore and innovate, prominent Spanish physicist José María Benlloch pointed out when he reviewed some of the most impacting and recent innovations in his portfolio during a meeting in Valencia. ‘Our mission is to develop innovative sensitive and harmless medical imaging instruments for early detection of diseases and…

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Article • Maps of the brain

7-Tesla MR enters clinical routine

Ultra-high-field magnetic resonance tomography with field strength of 7 Tesla is slowly but surely entering clinical routine. ‘Thanks to very high spatial and spectral resolution, ultra-high-field MR permits detailed views of the human anatomy and can show precisely the metabolic processes such as those in the brain,’ said Professor Siegfried Trattnig, from Vienna’s Medical University.

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Article • Prostate cancer detection

MRI tumour scans overlaid onto ultrasound

New medical software which overlays tumour information from MRI scans onto ultrasound images is helping to improve detection of prostate cancer by guiding surgeons as they conduct biopsies. Developed at University College London (UCL), the software is deployed via a system called SmartTarget and embraces artificial intelligence (AI) to use both systems in tandem to enable surgeons to pick up…

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News • Machine learning tool

AI can predict survival of ovarian cancer patients

Researchers have created a new machine learning software that can forecast the survival rates and response to treatments of patients with ovarian cancer. The artificial intelligence software, created by researchers at Imperial College London and the University of Melbourne, has been able to predict the prognosis of patients with ovarian cancer more accurately than current methods. It can also…

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News • Under pressure

Breast tissue stiffening promotes cancer development

A study provides new insight into how the stiffening of breast tissue plays a role in breast cancer development. By examining how mammary cells respond in a stiffness-changing hydrogel, bioengineers at the University of California San Diego discovered that several pathways work together to promote the transformation of breast cells into cancer cells. The work could inspire new approaches to…

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News • AI, IT, data management

Digital attack on cancer

Several research groups at Berlin Institute of Health (BIH) are working on digitally combating cancer. The main goal is to combine and jointly evaluate existing information. With 500,000 new cancer cases every year in Germany alone, it is worthwhile comparing experiences with different diagnostic and treatment methods, thus allowing more patients to benefit from the most promising approaches. In…

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News • Tiny threat

Nanoparticles may promote cancer metastasis

Nanoparticles can be found in processed food (e.g. food additives), consumer products (e.g. sunscreen) and even in medicine. While these tiny particles could have large untapped potential and novel new applications, they may have unintended and harmful side effects, according to a recent study by researchers from the National University of Singapore (NUS). Specifically, NUS researchers found that…

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News • Precision medicine

Europe looks to cells for a healthier future

How can we detect the first signs of disease as early as possible? Could closer investigation at the cellular level help to quickly prevent disease progression through appropriate treatment? The European Union is now investing a million euros over a one-year period to devise the plan for a fundamentally new approach to understanding the constant changes within cells and their relationships to one…

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News • DMD & rhabdomyosarcoma

Duchenne muscular dystrophy: Muscle stem cells can drive cancer

People with Duchenne muscular dystrophy (DMD) can develop an otherwise-rare muscle cancer, called rhabdomyosarcoma, due to the muscle cells’ continuous work to rebuild the damaged tissue. However, little is known about how the cancer arises, hindering development of a treatment or test that could predict cancer risk. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP)…

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Article • Getting personal(ised)

Pathology: Moving us towards precision medicine

The European Society of Pathology (ESP) holds its European Congress of Pathology (ECP) at different venues annually. This year, in Spain, 3,448 delegates from 87 countries attended. There, ESP president Dina Tiniakos spoke about the increasing role of pathology in precision medicine including challenges linked to digitisation. ‘Precision medicine is the centre-point for cancer management, but…

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News • Choline

Essential nutrient holds promise against Alzheimer’s

In a new study, researchers at the Biodesign Institute explore a safe and simple treatment for one of the most devastating and perplexing afflictions: Alzheimer’s disease (AD). Lead authors Ramon Velazquez and Salvatore Oddo, along with their colleagues in the Arizona State University (ASU)-Banner Neurodegenerative Disease Research Center (NDRC), investigate the effects of choline, an important…

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News • Radiotherapy side-effects

Skin fibrosis: new treatment for cancer patients

A clinical-scientific team specializing in head-and-neck cancer has identified a way to manipulate metabolism to potentially curb skin fibrosis – a common side effect of radiotherapy affecting quality of life of cancer survivors. The study findings from the laboratory of principal investigator Dr. Fei-Fei Liu, Chief, Radiation Oncology, Princess Margaret Cancer Centre, University Health…

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News • Oncology

COMPASS: The guide to new therapies for children with cancer

Through a targeted combination of molecular and microscopy-based techniques, researchers aim to identify new treatment approaches for children with cancer. The Hopp Children's Cancer Center Heidelberg (KiTZ) coordinates the project, which is funded by the European consortium ERA PerMed with 1.5 million euros and involves scientific institutions from France, the Netherlands, Finland and Hungary in…

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Article • Immuno-oncological biomarkers

Seeking to augment the value of tumour infiltrating lymphocytes

Measuring tumour infiltrating lymphocytes (TILs) is gaining importance in immunotherapy, but other variables must also be considered to boost prognosis and prediction accuracy, a leading pathologist argued at EBCC 11 last March in Barcelona. When it comes to prognosis and prediction for immunotherapy, a potentially new variable is emerging – TILs – white blood cells that have left the blood…

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News • Regenerative medicine

Blood cells can be directly reprogrammed into neural stem cells

Scientists from the German Cancer Research Center (DKFZ) and the stem cell institute HI-STEM* have succeeded for the first time in directly reprogramming human blood cells into a previously unknown type of neural stem cell. These induced stem cells are similar to those that occur during the early embryonic development of the central nervous system. They can be modified and multiplied indefinitely…

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Video • New treatment options

Unlocking the secrets of cell communication

Portland State University (PSU) researchers have made a significant breakthrough by developing the 3-D structure of proteins from inside the eye lens that control how cells communicate with each other, which could open the door to treating diseases such as cataracts, stroke and cancer. The PSU research team, led by chemistry professor Steve Reichow, used a multimillion-dollar microscope and a…

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News • Less rejection

Citrate-based biomaterial fuels bone healing

A material based on a natural product of bones and citrus fruits, called citrate, provides the extra energy stem cells need to form new bone tissue, according to a team of Penn State bioengineers. The new understanding of the mechanism that allows citrate to aid in bone regeneration will help the researchers develop slow-release, biodegradable citrate-releasing scaffolds to act as bone-growth…

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News • Non-invasive diagnostics

Detecting bladder cancer with atomic force microscopy

A research team led by Tufts University engineers has developed a non-invasive method for detecting bladder cancer that might make screening easier and more accurate than current invasive clinical tests involving visual inspection of bladder. In the first successful use of atomic force microscopy (AFM) for clinical diagnostic purposes, the researchers have been able to identify signature features…

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Video • Fighting cancer

'Zapping' tumors might be the future of radiation therapy

New accelerator-based technology being developed by the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University aims to reduce the side effects of cancer radiation therapy by shrinking its duration from minutes to under a second. Built into future compact medical devices, technology developed for high-energy physics could also help make radiation therapy more…

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Article • 'Is it safe?'

Effective communication on radiation risks

Communicating radiation risks is not only a legal requirement, it is also a moral obligation, asserts Dr Shane J Foley, radiographer and assistant professor at the UCD School of Medicine in Dublin, Ireland. Passing on radiation information has its pitfalls, but several helpful tools can improve communication, some of which the expert highlighted during ECR 2018.

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News • Going digital

Faster and better diagnosis of cancer with digital pathology

Leeds Teaching Hospitals NHS Trust and the University of Leeds have announced a critical milestone in going digital, by scanning every glass slide they produce. The milestone represents a major step towards achieving faster and accurate diagnosis for cancer patients in the future. The Pathology Department, located in St. James’ Hospital in Leeds, is one of the largest in the UK processing over…

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Article • New Italian study results

Pre-operative MRI endorsed for breast cancer

MRI offers unequalled sensitivity and specificity in breast cancer detection. Yet, it is poorly accepted preoperatively. Recently, eminent radiologist Francesco Sardanelli, professor for radiology at Milan University and Chief of Radiology at the IRCCS Policlinico San Donato in Italy, unveiled preliminary results that could further MRI acceptance among multidisciplinary teams.

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Article • Digital PET imaging

Digital Photon Counting improves diagnostic accuracy

Built as the first commercially available scanner to deliver truly digital PET, the Vereos PET/CT, from Philips, offers revolutionary Digital Photon Counting technology. The science behind this scanner evolution is ‘quite complicated’, agrees Piotr Maniawski, Director of Clinical Science Nuclear Medicine at Philips Healthcare, yet the improved performance is significant, particularly when…

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Article • Reducing prices

Coming up: Ultrasound for budget-conscious hospitals

Engineers have developed a new high-quality ultrasound transducer that could dramatically lower the cost of ultrasound systems. The innovation – created by a team from the University of British Columbia in Vancouver, Canada – is portable, wearable and can potentially be powered by a smartphone. Study lead, Dr Carlos Gerardo, from the university’s Department of Electrical and Computer…

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News • Bacterial infection

Laser-activated silk sealants outperform sutures for tissue repair

Researchers have developed laser-activated nanomaterials that integrate with wounded tissues to form seals that are superior to sutures for containing body fluids and preventing bacterial infection. Tissue repair following injury or during surgery is conventionally performed with sutures and staples, which can cause tissue damage and complications, including infection. Glues and adhesives have…

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News • Advanced materials

Nanocarriers open up to cancer

Nanosystems that deliver anticancer drugs or imaging materials to tumours are showing significant progress, particularly those that respond to tumour-related stimuli, according to a review published in the journal Science and Technology of Advanced Materials. However, further research is still required to make sure these delivery systems are stable, non-toxic and biodegradable. Nanocarriers…

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Article • Connected laboratory

Digitisation and automation: Game-changers in histopathology?

Often referred to as the ‘Achilles’ heel’ of histopathology, the sample entry has posed considerable challenges in pre-analytics for several decades. We visited the Munich-based lab automation start-up Inveox GmbH. Time-intense, highly manual processes in labs are expensive, error-prone and the most common reason for irregularities in cancer diagnoses. In Germany alone, every year hundreds…

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Article • Smartphone detection

Spectrometry? There's an app for that!

Checking a lump for malignancy, finding out if food is fresh, just with your smartphone? It’s possible, according to Eindhoven University of Technology researchers in the Netherlands. Their recently presented spectrometer is small enough to insert into a smartphone. This device is not yet ready for use on a big scale, Professor Andrea Fiore, supervisor of the Eindhoven research team points out.…

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Article • Cancer management

The enormous potential of liquid biopsy

It is non-invasive, delivers a chance of early diagnosis, prognostic information and sequential monitoring, and, believes Professor Francesco Salvatore, the enormous potential of liquid biopsies has still to be reached. However, the positive results obtained so far have ‘opened the door to a promising new multi-faceted group of tumour markers, at present collectively designated “liquid…

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News • Nanoparticle therapy

Putting a target on breast cancer

The complex structure of breast tumours makes treatment a medical challenge. A promising, novel selenium-based breast cancer nanoparticle therapy by the Austrian Centre of Industrial Biotechnology (acib) together with other partners in the EU-project Neosetac could change that: It has proved to boost the active agent delivery and assure it's active only in the target tissue while also bringing…

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News • It's all connected

Understanding the "wiring diagrams" of genes in complex tissues

How is the activity of all genes in cells of higher organisms interconnected? And how are the genetic "wiring diagrams" of the cells in complex tissues coordinated with each other? Scientists from the German Cancer Research Center (DKFZ), the European Molecular Biology Laboratory and the University of Heidelberg are now planning to investigate this in two model organisms, Drosophila and…

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News • Innovative material

'Smart' surfaces might pave the way for safer implants and better diagnostics

Researchers at McMaster University have solved a vexing problem by engineering surface coatings that can repel everything, such as bacteria, viruses and living cells, but can be modified to permit beneficial exceptions. The discovery holds significant promise for medical and other applications, making it possible for implants such as vascular grafts, replacement heart valves and artificial joints…

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Article • Updating laboratories

Digital pathology gains a foothold in Hungary

Hungary has one of the worst outcomes when it comes to cancer. Early detection and accurate diagnosis could significantly reduce the costs of oncological treatment. Pathology plays a crucial role in diagnoses, but is crippled by severe shortage and fragmentation. Digital pathology could help overcome those difficulties – and two projects underway seem particularly fit to help, László Fónyad,…

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News • Immunotherapy

Toward an “ultra-personalized” therapy for melanoma

With new immunotherapy treatments for melanoma, recovery rates have risen dramatically – in some cases to around 50%. But they could be much higher. A new study led by researchers at the Weizmann Institute of Science showed, in lab dishes and animal studies, that a highly personalized approach could help the immune cells improve their ability to recognize the cancer and kill it.

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Article • Going digital

DBT could boost breast screening

Tomosynthesis is under international review, with a surprising number of enticing studies carried out in Northern European countries, among them one headed by Professor Sophia Zackrisson at Lund University, Sweden. In our interview, she not only revealed surprising trial results, but also shared her thoughts on practical implementation and unusual speed-reading methods. ‘Our institute’s…

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News • Tech from Taiwan

Augmented reality is the future of surgery

Physicians have been performing surgery with the assistance of x-ray technology for almost half a century. While this technology has been progressing steadily, its limitations continue to be a major challenge. Thus, many professionals agree: it's time for our method to be changed. Taiwan Main Orthopaedics Biotechnology introduced the worldwide first smart surgical glasses.

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News • Gastroenterology

High-fat diet can cause pancreatic cancer – but there's hope

A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK), a digestive hormone. In addition, blocking CCK may help prevent the spread of pancreatic tumors to other areas of the body (metastases). The new findings are published ahead of print in the American Journal of Physiology—Gastrointestinal…

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News • Switching sides

How cancer cells 'brainwash' their foes

It doesn’t often happen that army generals switch sides in the middle of a war, but when cancer is attacking, it may cause even a gene that acts as the body’s master defender to change allegiance. Researchers at the Weizmann Institute of Science have discovered that this gene’s betrayal can occur in more ways than previously appreciated – and might even return the renegade cells to their…

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News • bioengineering

Advancing technique for of personalied bone grafts

Scientists have developed a new bone engineering technique called Segmental Additive Tissue Engineering (SATE). The technique allows researchers to combine segments of bone engineered from stem cells to create large scale, personalized grafts that will enhance treatment for those suffering from bone disease or injury through regenerative medicine.

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Article • Heard at the 14th ECDP in Helsinki

Digital pathology: Sometimes AI can outperform experts

Machine learning is adding a new dimension to pathology and already outperforming experts during some tasks, according to several speakers at the 14th European Congress on Digital Pathology (ECDP) who revealed up-to-date developments. However, whilst AI is set to herald a new future for digital pathology, Johan Lundin, associated professor for biomedical informatics and research director at the…

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Article • Gaining ground

MRI advances approach the realm of precision medicine

MRI has developed rapidly over the past decade in Poland, where clinicians are combining MRI with PET and CT to highlight tumour growth or regression and perfusion. ‘The fact that MRI offers new software and programmes means we can diagnose pathologies more precisely and make a diagnosis faster than a few years ago,’ explained Poland’s national advisor on radiology and diagnostic imaging…

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News • Live long and prosper

Key molecule of aging discovered

Every cell and every organism ages sooner or later. But why is this so? Scientists at the German Cancer Research Center in Heidelberg have now discovered for the first time a protein that represents a central switching point in the aging process. It controls the life span of an individual - from the fly to the human being. This opens up new possibilities for developing therapies against…

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News • Gas embolotherapy

Blowing bubbles for cancer treatment

Recently, scientists have explored another version of embolization, called gas embolotherapy. During this process, the blood supply is cut off using acoustic droplet vaporization (ADV), which uses microscopic gas bubbles induced by exposure to ultrasonic waves. A team of researchers from China and France has discovered that these bubbles could also be used as potential drug delivery systems.

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News • New research

Circulating tumor cells to help stage metastatic breast cancer

Menarini Silicon Biosystems announced that a new study has found that using circulating tumor cells (CTCs), a form of liquid biopsy, holds promise as a key tool for developing a staging system that can have a significant impact in the treatment of metastatic breast cancer (MBC). In this study, the largest CTCs pooled analysis study to date, researchers determined that the CTC count could be used…

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News • Hematopoietic Stem Cells

What keeps our blood in balance

Blood is the juice of life, as while circulating through the body it delivers vital substances such as oxygen and nutrients to cells and tissues. Chemotherapy, radiotherapy and blood loss in general impoverish the system. A special kind of cells in the bone marrow, called hematopoietic stem cells (HSCs) is able to replenish the impoverished system by giving rise not only to red blood cells, but…

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News • New study

Pancreatic cancer: Chemotherapy goes platinum

A small study of adults with the most common form of pancreatic cancer adds to evidence that patients with BRCA1 or BRCA2 gene mutations long linked to a high risk of breast cancer have poorer overall survival rates than those without the mutations. The same study also found that those with BRCA1 or BRCA2 had better survival rates with platinum-based chemotherapy, compared with similar patients…

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News • Photoacoustics

New method shows 3D images of cancer cells in the body

Making tumour cells glow: Medical physicists at Martin Luther University Halle-Wittenberg (MLU) have developed a new method that can generate detailed three-dimensional images of the body's interior. This can be used to more closely investigate the development of cancer cells in the body. The research group presents its findings in "Communication Physics".

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News • High throughput screening

Tumor-like spheres to help discover smarter cancer drugs

Cancer is a disease often driven by mutations in genes. As researchers learn more about these genes, and the proteins they code for, they are seeking smarter drugs to target them. The ultimate goal is to find ways to stop cancer cells from multiplying out of control, thereby blocking the growth and spread of tumors. Now researchers from The Scripps Research Institute are reporting an innovative…

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News • Idiopathic pulmonary fibrosis

The most dangerous lung disease you've never heard of

Idiopathic pulmonary fibrosis (IPF) is one of the most challenging and frustrating diseases that pulmonologists face. And despite affecting 1 out of 200 adults over the age of 65 in the United States, general awareness of IPF is low. “There’s a tremendous disconnect between the human impact of this disease and its recognition by the public. Few people have ever heard of it,” says Marc…

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Article • Precision medicine

Promising radiomics for breast MRI

‘Breast cancer rates are continuously increasing, and we don’t yet have a means of prevention,’ said Dr Clemens Kaiser, from the Medical Faculty Mannheim, at Heidelberg University, who believes the only way to save more patients from death, after providing the best possible diagnostics procedures, is via precision medicine: the right treatment at the earliest possible time. The radiologist…

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News • Bone health

Osteoporosis defined: causes, symptoms and treatments

Weak, easily broken bones are an epidemic in the United States. They’re often tied to osteoporosis, a disease that causes bones to degenerate over time. This makes them less flexible, more brittle, and easier to break. According to the International Osteoporosis Foundation, more than 44 million Americans aged 50 and older either have or face the threat of developing osteoporosis due to low bone…

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Sponsored • Exhibition

Progress in medicine presented at Bulmedica/Buldental 2018

New products and technologies in medical practice expect the specialists of the leading international exhibition Bulmedica/Buldental from 16 to 18 May at Inter Expo Center. This year, the medical profile of the exhibition will focus on the progress in imaging, physiotherapy, aesthetic medicine. Once again Bulmedica/Buldental will be a platform to keep an eye on the tendencies, a meeting point of…

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News • Groundbreaking technique

Noninvasive brain tumor biopsy on the horizon

Taking a biopsy of a brain tumor is a complicated and invasive surgical process, but a team of researchers at Washington University in St. Louis is developing a way that allows them to detect tumor biomarkers through a simple blood test. Hong Chen, a biomedical engineer, and Eric C. Leuthardt, MD, a neurosurgeon, led a team of engineers, physicians and researchers who have developed a…

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News • New report

Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening

A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for…

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News • Oncology imaging

‘Digistain’ technology offers revolution in detailed cancer diagnosis

A new imaging technology to grade tumour biopsies has been developed by a team of scientists led by the Department of Physics and the Department of Surgery and Cancer at Imperial College London. Publishing their results in the journal Convergent Science Physical Oncology, they describe how their new method promises to significantly reduce the subjectivity and variability in grading the severity…

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News • Joint disease

Nanotechnology detects molecular biomarker for osteoarthritis

For the first time, scientists at Wake Forest Baptist Medical Center have been able to measure a specific molecule indicative of osteoarthritis and a number of other inflammatory diseases using a newly developed technology. This preclinical study used a solid-state nanopore sensor as a tool for the analysis of hyaluronic acid (HA). HA is a naturally occurring molecule that is involved in tissue…

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News • DNA analysis

Magnetic biosensor array simplifies cancer detection

In standard settings, the analysis of each DNA modification requires a carefully optimised assay that runs under specific conditions. This increases cost and labour and is a severe limitation to throughput. Now, however, researchers at Stanford University and the Technical University of Denmark have come up with a new method that will enable doctors to make a more precise diagnosis, prognosis and…

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Article • Women's health

Benign gynaecology specialist centres are needed

The recently opened Uterine Repair Center (URC) in VUmc (Amsterdam) serves women suffering non-cancerous gynaecological disorders, such as myomas, adenomyosis (endometriosis of the uterus), niches (caesarean scar defects) or congenital uterine abnormalities. Gynaecologist Professor Judith Huirne leads the clinic – but has greater aspirations.

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Article • Cancer diagnostics

Progressing towards optical biopsy

Recognising malignant tissue remains a tricky task. While today, most patients undergo a biopsy, an invasive procedure where tissue is sampled, stained and assessed, researchers are exploring the potential of optical biopsy, the visual assessment of suspect tissue. The interest in optical biopsy ‘is indeed enormous,’ confirms Dr Thomas Bocklitz, physicist at Friedrich-Schiller University in…

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Article • Predictive biomarkers

Immunotherapy follow-up with MRI: the search is on

Immunotherapy is taking center stage in imaging, but patient follow-up with CT is no cookie and may fall short in the peripheral limbs, brain and bone marrow. MRI offers specific benefits in these situations, and, combined with PET, it may bring even more results. Research must be carried out on quantitative techniques and tracers developed to fully exploit that potential, Prof. Dow-Mu Koh…

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Article • Tomosynthesis

Catching more invasive cancers earlier

What beats digital mammography to detect breast cancer in asymptomatic women? Digital breast tomosynthesis (DBT) – was a big discussion at RSNA 2017. Sarah M Friedewald MD, medical director of the Lynn Sage Comprehensive Breast Center of Northwestern Memorial Hospital in Chicago and its division chief of breast and women’s imaging, discussed the clinical implications of DBT for routine…

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Sponsored • World-class technologies

New cutting-edge products and clinical applications

“With Your Stories – lifetime healthcare support” is the ­future-driven approach combining the best of two worlds by using our insight and expertise in medical imaging systems and laboratory instrumentation to benefit patients through even better prevention, diagnosis, treatment and follow-up and thus help them in the pursuit of a healthy life.

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Article • The InnerEye Project

AI drives analysis of medical images

Some time in the distant future artificial intelligence (AI) systems may displace radiologists and many other medical specialists. However, in a far more realistic future AI tools will assist radiologists by performing very complex functions with medical imaging data that are impossible or unfeasible today, according to a presentation at the RSNA/AAPM Symposium during the Radiological Society of…

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Article • A valuable tool for reconstruction

Augmented reality lets surgeons ‘see’ inside limbs

Researchers at Imperial College London (ICL) have shown how the Microsoft HoloLens headset can be used during reconstructive lower limb surgery. Surgeons at London’s St Mary’s Hospital are using the device, a self-contained computer headset that immerses the wearer in ‘mixed reality’, enabling them to interact with holograms visible through the visor.

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News • Follow-ups

Early countermeasures against ineffective cancer therapies

What effect does a particular cancer medicine or radiation therapy have on patients? To find out, physicians use CT images to determine whether a tumor’s size changes during the course of treatment. In the PANTHER project, a joint team of experts aims at gaining further valuable information from these images. In the future, doctors will be able to find out at an early stage whether a cancer…

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News • When proteins go bad

Data detectives uncover new suspect in Alzheimer's

The mass pursuit of a conspicuous suspect in Alzheimer’s disease may have encumbered research success for decades. Now, a new data analysis that has untangled evidence amassed in years of Alzheimer’s studies encourages researchers to refocus their investigations. Heaps of plaque formed from amyloid-beta that accumulate in afflicted brains are what stick out under the microscope in tissue…

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News • Histology in 3D

New staining method enables Nano-CT imaging of tissue samples

To date, examining patient tissue samples has meant cutting them into thin slices for histological analysis. This might now be set to change – thanks to a new staining method devised by an interdisciplinary team from the Technical University of Munich (TUM). This allows specialists to investigate three-dimensional tissue samples using the Nano-CT system also recently developed at TUM. Tissue…

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News • Advanced techniques

Breast cancer: how imaging technology will help avoid unnecessary biopsies

Enhancing the diagnosis of breast cancer is the stated goal of a research team at the German Cancer Research Center (DKFZ) in Heidelberg. The scientists have combined an advanced method of diffusion-weighted MR imaging with intelligent image analysis methods to detect malignant changes in tissues. This method may help avoid many control biopsies following suspicious findings from mammography…

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News • Beyond PSA monitoring

New prostate cancer risk model could better guide treatment

One of the biggest challenges in treating prostate cancer is distinguishing men who have aggressive and potentially lethal disease from men whose cancer is slow-growing and unlikely to metastasize. For years, prostate-specific antigen (PSA) level, cancer grade and tumor stage have been used to sort prostate cancer patients into risk groups established by the National Comprehensive Cancer Network.…

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News • Responsive or not?

Breast cancer: Near-infrared light shows chemo beneficiaries

A new optical imaging system developed at Columbia University uses red and near-infrared light to identify breast cancer patients who will respond to chemotherapy. The imaging system may be able to predict response to chemotherapy as early as two weeks after beginning treatment. Findings from a first pilot study of the new imaging system—a noninvasive method of measuring blood flow dynamics in…

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News • In wine, there’s health

Low levels of alcohol might actually be good for your brain

While a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well. The new study, which appears in the journal Scientific Reports, shows that low levels of alcohol consumption tamp down inflammation and helps the brain clear away toxins, including those associated with Alzheimer’s disease. “Prolonged intake of…

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Article • Old technique & new technology

Optoacoustics: the sound of cells

For centuries, hands, eyes and ears were the physicians’ most important instruments when it came to detecting and diagnosing disease. Today, one of the traditional techniques, percussion, is being revived, supported by state-of-the-art technology and dressed in a new name: optoacoustics. In one of the most exciting visionary ideas in modern healthcare short laser pulses (optics) are transmitted…

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News • Microbubbles

Bracco Imaging to innovate ultrasound for new personalized gene therapy

Bracco Imaging S.p.A., a global leader in diagnostic imaging, announced that it has initiated new experimental activities in its R&D Center in Geneva, Switzerland, to explore a new application for gas-filled microbubbles in the development of personalized gene therapy for treatment of chronic dysfunctional diseases related to lipid metabolism. Microbubbles have already revolutionized medical…

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News • Radiation therapy

New gel reduces side effects of prostate cancer treatment

Radiation therapy is a popular and effective treatment for many men with prostate cancer, and now a temporary gel offers greater protection for organs at risk during treatments. “Treating prostate cancer with radiation therapy can cause unintended injury to adjacent, healthy tissue, which can lead to bowel and urinary problems, as well as erectile dysfunction,” said Daniel Krauss, M.D., a…

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News • Efferocytosis

Can stem cell exosome therapy reduce fatal heart disease in diabetes?

Macrophage cells routinely remove dead or dying cells to maintain the body homeostasis. Such removal becomes crucial after serious injury, especially the repair of dead heart muscle after a heart attack. University of Alabama at Birmingham researchers have preliminary data, with cultured cells or diabetic hearts, that diabetes impairs this removal of dead heart-muscle cells. They believe this…

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News • Animal testing

Can mice really mirror humans when it comes to cancer?

A new Michigan State University study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer. The findings, now published in PLOS Genetics, reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.…

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News • Pressure monitoring

This biodegradable sensor disappears after its job is done

Engineers at the University of Connecticut (UConn) have created a biodegradable pressure sensor that could help doctors monitor chronic lung disease, swelling of the brain, and other medical conditions before dissolving harmlessly in a patient’s body. The UConn research is featured in the current online issue of the Proceedings of the National Academy of Sciences. The small, flexible sensor is…

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News • Cancer research

Bioengineered soft microfibers improve T-cell production

T cells play a key role in the body’s immune response against pathogens. As a new class of therapeutic approaches, T cells are being harnessed to fight cancer, promising more precise, longer-lasting mitigation than traditional, chemical-based approaches. These “living drugs” are poised to transform medicine, with a growing number of cellular therapies receiving FDA-approval. A current…

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News • Breast biopsy

Hologic's Brevera system receives European CE mark

Hologic, Inc. announced it has obtained a CE Mark in Europe for the Brevera breast biopsy system with CorLumina imaging technology, a groundbreaking real-time breast biopsy and verification system that improves the patient experience and streamlines the biopsy process from start to finish. The first-of-its-kind Brevera system is designed to increase biopsy accuracy with real-time imaging that…

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News • Rhabdomyosarcoma

Muscle cancer - or is it?

St. Jude Children’s Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children. Previously, scientists thought the cancer arose from immature muscle cells, because the tumor resembled muscle under the microscope. However, the St. Jude researchers discovered the cancer arises from immature progenitors that…

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News • Oncology and critical care treatment

GE and Roche partner up for integrated digital diagnostics platform

GE Healthcare has entered into a strategic, long-term partnership with Roche to jointly develop and co-market digital clinical decision support solutions. The partnership will initially focus on products that accelerate and improve individualized treatment options for cancer and critical care patients. The two companies aim to develop an industry-first digital platform, using advanced analytics…

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News • Milestone

Researcher grow hairy skin in a dish

Researchers at Indiana University School of Medicine have successfully developed a method to grow hairy skin from mouse pluripotent stem cells - a discovery that could lead to new approaches to model disease and new therapies for the treatment of skin disorders and cancers.

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News • Experimental medicine

Loophole in chronic lymphocytic leukemia treatment detected

A team of researchers in Italy and Austria has determined that a drug approved to treat chronic lymphocytic leukemia (CLL) may be less effective in a particular subset of patients. The study, published in the Journal of Experimental Medicine, reveals that ibrutinib has a diminished capacity to delocalize and kill tumor cells expressing an adhesive protein called CD49d, but combining ibrutinib…

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Video • mpMRI

State-of-the-art MRI technology bypasses need for kidney biopsy

The most common type of tumor found in the kidney is generally quite small (less than 1.5 in). These tumors are usually found by accident when CAT scans are performed for other reasons and the serendipitous finding poses a problem for doctors. Are these tumors malignant and do they need to be surgically removed because they may threaten the patient’s life? Or are they benign and can be left…

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News • Macrophages

How immune cells help early breast cancer spread

Mount Sinai researchers have discovered that normal immune cells called macrophages, which reside in healthy breast tissue surrounding milk ducts, play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even developed, according to a study published in Nature Communications. The macrophages play a role…

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News • Antiviral design

CAR-T gene therapy could provide long-term HIV protection

Through gene therapy, researchers engineered blood-forming stem cells (hematopoietic stem/progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV-infected cells. These engineered cells not only destroyed the infected cells, they persisted for more than two years, suggesting the potential to create long-term immunity from the virus…

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Video • "Stormram 4"

This 3D-printed robot could be the future of cancer treatment

Cancer surgeons perform an estimated 1.7 breast biopsies each year, according to the American Association of Preferred Provider Organizations. This makes the procedure a significant proportion of cases referred to anatomic pathologists. This surgery, however, is time-consuming and not always accurate due to shortcomings in existing surgical technology and to human error. Now, a 3D-printed…

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News • Ventricular tachycardia

Deadly heart rhythm halted by noninvasive radiation therapy

Radiation therapy often is used to treat cancer patients. Now, doctors at Washington University School of Medicine in St. Louis have shown that radiation therapy — aimed directly at the heart — can be used to treat patients with a life-threatening heart rhythm. They treated five patients who had irregular heart rhythms, called ventricular tachycardia, at the School of Medicine. The patients…

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News • Light it up

Faster, more accurate cancer detection using nanoparticles

Using light-emitting nanoparticles, Rutgers University-New Brunswick scientists have invented a highly effective method to detect tiny tumors and track their spread, potentially leading to earlier cancer detection and more precise treatment. The technology could improve patient cure rates and survival times. “We’ve always had this dream that we can track the progression of cancer in real…

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News • Infiltrating tumors

Immune cells predict therapy response in breast cancer

When immune cells invade the tumor, this is usually considered a good sign because the body's own immune system appears to be responding to the cancer. In the case of certain types of breast cancer immune cells, namely so-called tumor-infiltrating lymphocytes (TILs), these can determine survival rates and predict the usefulness of chemotherapy. This was shown by the largest meta study on TIL…

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News • Enzyme discovery

Epigenetic agitator of pancreatic cancer cells identified

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect…

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News • Photoacoustic imaging

Breast cancer surgery without lab testing and pathology reports may soon be a reality

Determining where breast cancer ends and healthy tissue begins is a critical part of breast cancer surgery. Surgeons are used to working closely during surgery with anatomic pathologists who generate pathology reports that specify the surgical or tumor margin, an area of healthy tissue surrounding a tumor that also must be excised to ensure none of the tumor is left behind. This helps prevent the…

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News • Innovative approach

New “Swiss Army Knife” nanovaccine to battle tumors

Scientists are using their increasing knowledge of the complex interaction between cancer and the immune system to engineer increasingly potent anti-cancer vaccines. Now researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a synergistic nanovaccine packing DNA and RNA sequences that modulate the immune response, along with anti-tumor antigens, into…

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Article • Early detection

From detection to treatment response

Imaging is increasingly useful in detecting colorectal cancer (CRC) liver metastases and evaluating how these lesions respond to treatment. Dr Daniele Regge reviewed all the latest advances during last September’s Madrid meeting of the European Society of Medical Oncology (ESMO)

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Article • Beyond palliative care

Perspectives of SIRT – who benefits and why?

Selective internal radiotherapy (SIRT) is often only looked at from a palliative perspective. However, the procedure is now also increasingly moving into the curative field, as Prof. Dr. Jens Ricke, Chair of Radiology at the Ludwig-Maximilian University Munich and Director of the Clinic and Polyclinic for Radiology at the University Hospital of the LMU reports. “As a locoregionally used…

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News • Innovation

Samsung introduces new premium ultrasonic diagnosis device 'RS85'

Samsung Medison, a global medical equipment company and an affiliate of Samsung Electronics, introduced the RS85, a new premium ultrasonic diagnosis device that provides enhanced image quality, usability, and convenience for medical and radiology professionals. “We are pleased to launch the RS85, a new premium medical device with superior image quality and usability based on Samsung’s…

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Sponsored • Innovation

The future of elastography rides on the shear wave

A practicing radiologist specialising in ultrasound, Pavlos Zoumpoulis MD PhD is also President and CEO of Diagnostic Echotomography, a day clinic based in Kifissia, Greece. The past President of the Hellenic Society of Ultrasound in Medicine and Biology spoke with our European Hospital team about his experiences with the next-generation in shear wave elastography on Mindray’s Resona 7 platform.

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News • Innovation

Novel Nano-CT magnifies tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of…

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Article • Hybrid imaging

PET/MRI leads hybrid imaging

Hybrid imaging is still a leading topic in radiology – underlined by the 14 related sessions held during the 29th European Congress of Radiology (ECR 2017) held in Vienna, this March. Those sessions focused on the combination of radiological and nuclear medical imaging procedures that aim to visualise morphology as well as function, structure and metabolism of an organ or region of interest.

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News • Neurotransmissions

Nanosensors uncloak the mysteries of brain chemistry

Nanosensors are incredible information-gathering tools for myriad applications, including molecular targets such as the brain. Neurotransmitter molecules govern brain function through chemistry found deep within the brain, so University of California, Berkeley researchers are developing nanosensors to gain a better understanding of exactly how this all plays out. During the AVS 64th…

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Article • Ultrasound

Controversies and practices in breast cancer screening

A controversy regarding the benefit of early screening programmes for breast cancer continues. Germany, Austria and Switzerland have developed individual strategies. European Hospital asked three experts from these countries to outline each chosen system. Markus Hahn MD, senior consultant at the University Breast Centre in Tübingen, Martin Daniaux, MD, Head of Breast Diagnostics at the Breast…

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Article • Abbreviated MRI

Seeking a view through the dense breast

Despite rigorous quality assurance of breast cancer screening programs, ‘both, over- and under-diagnosis of breast cancer is a challenge,’ says leading radiologist Christiane K Kuhl, from the Department of Diagnostic and Interventional Radiology, at the University of Aachen, Germany. ‘Mammography is a good screening test – but has its limitations especially, but not only, in women with…

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News • Cancer research

Researchers release the brakes on the immune system

Many tumors possess mechanisms to avoid destruction by the immune system. For instance, they misuse the natural “brakes” in the immune defense mechanism, which normally prevent an excessive immune response. Researchers at the University of Bonn have now been able to take off one of these brakes. The study, which involved colleagues from Hamburg and Würzburg, could pave the way for more…

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News • Cancer research

Esophageal cancer “cell of origin” identified

Columbia University Medical Center (CUMC) researchers have identified cells in the upper digestive tract that can give rise to Barrett’s esophagus, a precursor to esophageal cancer. The discovery of this “cell of origin” promises to accelerate the development of more precise screening tools and therapies for Barrett’s esophagus and esophageal adenocarcinoma, the fastest growing form of…

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News • Research project

Can new molecular imaging technology guide prostate cancer surgery?

The Netherlands Cancer Institute (NKI) announced that it has received funding from the Dutch Cancer Society to test whether a novel molecular imaging technology can guide prostate cancer surgery. The project will evaluate the imaging technology’s ability to detect prostate cancer during surgery, with the aim of performing more accurate removal of cancerous tissue. Prostate cancer is the most…

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News • Phosphatidic acid phosphatase

A fat-regulating enzyme could hold the key to obesity and diseases

It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists at Rutgers University-New Brunswick have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation and other ills.

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News • Handheld mass spectrometer

This pen may be mightier than cancer

A team of scientists and engineers at The University of Texas at Austin has invented a powerful tool that rapidly and accurately identifies cancerous tissue during surgery, delivering results in about 10 seconds—more than 150 times as fast as existing technology.

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News • Cooperation

Pentax and Hitachi launch new ultrasound video bronchoscope

Pentax Europe, a healthcare industry leader in endoscopic imaging, and Hitachi Medical Systems Europe, a leading company in medical imaging, recently announced renewed joint collaborative efforts to enable further innovations in the development of endoscopic ultrasound (EUS). In this latest joint development, the two companies are launching a new ultrasound video bronchoscope for endobronchial…

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News • Study

Zika virus could be used to treat brain cancer

Recent outbreaks of Zika virus have revealed that the virus causes brain defects in unborn children. But researchers from Washington University School of Medicine in St. Louis and the University of California, San Diego report that the virus could eventually be used to target and kill cancer cells in the brain.

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News • Combination approach

Radiation treatment extends life expectancy for patients with inoperable lung cancer

Patients with unresectable, or inoperable, lung cancer are often given a dismal prognosis, with low rates of survival beyond a few years. Researchers exploring combination therapies have recently discovered improved survival rates by up to one year when patients treated with a newly formulated chemotherapy regimen are also given radiation therapy.

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News • DNA fragments

Using barcodes to trace blood cell development

There are various concepts about how blood cells develop. However, they are based almost exclusively on experiments that solely reflect snapshots. In a publication in Nature, scientists from the German Cancer Research Center in Heidelberg now present a novel technique that captures the process in a dynamic way.

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Article • Mutated DNA in blood

Liquid biopsy detects tumour changes in real time

New findings from a scientific collaboration between the German Cancer Research Centre (DKFZ), the National Centre for Tumour Diseases (NCT) Heidelberg and the Thoraxklinik Heidelberg suggest liquid biopsy as a promising tool to monitor lung cancer patient tumours early. Scientists associated liquid biopsy readouts with clinical data and could track tumour responses to cancer drugs in real-time.

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Article • Skin protection

Self-improving DNA sun screen developed

Researchers at Binghamton University, State University of New York have developed a coating made out of DNA that gets better at protecting skin from Ultraviolet light the more it is exposed to the sun and which could potentially be used as wound covering for extreme environments.

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Article • Gadolinium-based contrast agents

Clinicians define optimal approach for MRI contrast to maximize benefit

Gadolinium-based contrast agents are an essential component of MRI exams, but are challenged by findings of residual depositions of gadolinium in the body, even though the clinical relevance remains unknown. Three clinicians described how changes to MRI protocols and dose levels for contrast media can optimise the balance between benefit and risk for patients and radiologists.

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News • Hybrid imaging

Siemens Healthineers debuts Symbia Intevo Bold SPECT/CT

At the 2017 annual meeting of the Society of Nuclear Medicine & Molecular Imaging (SNMMI), June 10-14 at Denver’s Colorado Convention Center, Siemens Healthineers debuts Symbia Intevo Bold, a system that combines the company’s proven single-photon emission computed tomography (SPECT) technologies with new, high-performance CT capabilities to enable a wide range of clinical applications.

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News • Cancer development

Tumor induction from a distance

Current view is that cancer development is initiated from cells that acquire initial DNA mutations. These in turn provoke additional defects, and ultimately the affected cells begin to proliferate in an uncontrolled manner to develop primary tumors. These can later spread and create metastases, or secondary tumors, in other parts of the body. However, according to a study by researchers at the…

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News • Under the skin

Handheld scanner reveals vascularization in psoriasis patients

A newly developed tissue scanner allows looking under the skin of psoriasis patients. This provides clinically relevant information, such as the structure of skin layers and blood vessels, without the need for contrast agents or radiation exposure. A team of researchers from Helmholtz Zentrum München and the Technical University of Munich (TUM) recently introduced the technology in ‘Nature…

News • Diabetes research

Healing burn wounds with cell therapy

An experimental treatment in mice allows the reprogramming of blood cells in order to promote the healing process of cutaneous wounds. This approach could prove to be beneficial in healing challenging wounds in diabetics and major-burn victims.

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Sponsored • Mammography

Evolving breast imaging with MARIA™

Breast cancer continues to be one of the biggest killers of women globally. Worldwide it is estimated that around 522,000 women died from breast cancer in 2012. This is despite the fact that if a cancer is detected at less than 1cm in size with no lymph involvement survival rates at 5 years are comparable with someone who has not had cancer.

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News • Imaging technology

Visiopharm engages in major initiative for Deep Learning

Visiopharm A/S announces the first result of their multifaceted strategy to apply Deep Learning technologies to its leading image analysis solution for cancer research and diagnostics. Visiopharm considers Deep Learning an important technological breakthrough for tissue pathology that offers the potential to make a real difference in the assessment of tissue structures, which is probably one of…

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News • Breast Cancer

Biomarker Identified for Likely Aggressive, Early Stage Breast Cancer

The one-size-fits-all approach to early stage breast cancer creates a paradox: Millions of dollars are spent on unnecessary surgeries and radiation to treat women with low-risk ‘in situ’ lesions, an estimated 85% of which would never progress to invasive cancers. Meanwhile, the standard conservative treatment is insufficient for many early-stage tumors that have progressed past the in situ…

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Article • Deep Learning

Philips and LabPON plan to create world’s largest pathology database

Royal Philips (NYSE: PHG, AEX: PHIA) and LabPON, the first clinical laboratory to transition to 100% histopathology digital diagnosis, today announced its plans to create a digital database of massive aggregated sets of annotated pathology images and big data utilizing Philips IntelliSite Pathology Solution1. The database will provide pathologists with a wealth of clinical information for the…

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News • Liver-Surgery

Ultrasound scalpel destroys liver tumors

Focused ultrasound can effectively destroy tumor cells. Until now, this method has only been used for organs such as the prostate and uterus. At the European Congress of Radiology, Fraunhofer researchers will present a method, developed as part of the TRANS-FUSIMO EU project, that enables focused ultrasound treatment of the liver, an organ that moves while breathing. In the future, this could…

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Article • Women's health

Built for comfort; created for speed

The new Sofia 3-D breast ultrasound system solves all the economic and logistic challenges associated with whole-breast ultrasound by using a full-field radial scanning method, the firm reports. The resulting throughput, efficiency, and patient comfort make Sofia an ideal solution for women with dense breasts.

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Scientists tissue-engineer part of human stomach

Researchers at Cincinnati Children’s Hospital Medical Center grew functional stomach and intestinal tissues to study diseases and new drugs. They use pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes.

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News • Positron emission tomography

New imaging method detects prostate cancer

An international group of researchers report success in mice of a method of using positron emission tomography (PET) scans to track, in real time, an antibody targeting a hormone receptor pathway specifically involved in prostate cancer.

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Article • Xenon MRT

A revolution in lung function diagnostics

Since lung diseases tend to be complex, imaging is a crucial diagnostic tool. While computed tomography has become the standard modality, which is frequently used outside hospital settings, specialised MRI diagnostics remains the preserve of large university medical centres.

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Article • Surgery 4.0

Robots will not see off human specialists

Big Data, automation, and artificial intelligence – no doubt, all these developments will have an impact on surgery. During our interview, Professor Hubertus Feußner, Head of the interdisciplinary research group ‘Minimally invasive interdisciplinary therapy intervention’ at the Technical University Munich, Germany, and Professor Christoph Thümmler, Professor for eHealth at Edinburgh…

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Article • Denmark

Successful digital pathology

Advanced computer software underpins a service - coupled with a countrywide database, which enables Denmark’s pathologists to optimise the assessment of patients’ specimens.In turn, the digitisation of the system in recent years has led to significant improvements in pathology services, delivering greater efficiency and advances in patient safety.

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Article • Contrast enhancement

Sonic boom with bubbles

Illuminating blood vessels, opening the blood-brain barrier and delivering drugs. What will be the next big thing that tiny microbubbles can do?

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Article • Challenging process

Embracing digitised pathology

Investing in equipment and systems, training personnel and picking the right manufacturer to deliver a system that meets a hospital’s needs are key factors, according to Dr Peter Riegman, Head of Erasmus MC Tissue Bank at Erasmus MC in Rotterdam.

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Interview • Endoscopy

New devices deliver exceptional clarity

This year Pentax Medical launches three premium products for use in gastroenterology, Ear nose and throat (ENT) and bronchoscopy. These result from highly focused global research and development, for which Mike Drexel, the company’s Chief Technology Officer, is responsible. In our interview he discusses how the firm’s globalised approach to product research and development has taken shape.

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News • Oncology

Nanoparticle creates ‘wave of destruction’ in cancer cells

Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer. Now, the ultrasmall particles – developed more than a dozen years ago by Ulrich Wiesner, the Spencer T. Olin Professor of Engineering at Cornell University – have shown they can do something even better: kill cancer cells without attaching a cytotoxic drug.

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Article • Tomosynthesis

Additional cancer screening for women with dense breasts

Italian-led research has highlighted the value of utilising additional screening technologies to help diagnose breast cancer in some women. Interim analysis from the Adjunct Screening with Tomosynthesis or Ultrasound in Women with Mammography-Negative Dense Breasts (ASTOUND) study has delivered evidence of the potential benefit of adding either ultrasound or tomosynthesis to standard mammograms…

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Overcoming multidrug-resistant cancer with smart nanoparticles

Multidrug resistance (MDR) is the mechanism by which many cancers develop resistance to chemotherapy drugs, resulting in minimal cell death and the expansion of drug-resistant tumors. To address the problem of resistance, researchers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (NIH) have developed nanoparticles that…

News • Oncology

Infra-red light to deteact early signs of oesophageal cancer

Researchers at the Cancer Research UK Cambridge Institute sprayed a dye on oesophageal tissue samples taken from people with Barrett’s oesophagus – a condition that increases the risk of developing oesophageal cancer. The dye sticks to healthy oesophageal cells but not to pre-cancerous cells. They then shone near-infrared light - which is just beyond the red colours that our eyes can normally…

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Plasma: A technology to improve bone healing?

Cold plasma looks like the glow from the “Star Wars” blue light saber but this beam of energy, made of electrons that change polarity at micro-second or nanosecond speeds, could help bones heal faster, according to researcher from the Thomas Jefferson University.

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Article • Reconstructive Surgery

Robots hold a steadying role in microsurgery

Embracing robotic technology in the realms of microsurgery will have significant benefits for patients, clinicians and hospitals. Leading hand and peripheral nerve specialist Professor Philippe Liverneaux believes using robots will not only enhance patient outcomes and improve cosmetic appearance but also bring significant cost benefits to health systems.

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Interview • Touching

Robotic surgery - haptic feedback is a possibility

Robot-assisted surgery still meets with considerable skepticism even though Intuitive Surgical’s Da Vinci system has been around for more than a decade. However, few surgeons and researchers are seeking ways to expand the surgical toolbox. Not so the members of the working group ‘Surgical technology and training’ at the General, Visceral and Transplantation Surgery Department, University…

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News • Research

New Biomarker for cancer immunotherapy?

The Ligand PD-L1 is one of the most important targets for cancer immunotherapy with checkpoint inhibitors. But not all tumors have sufficient quantities of PD-L1 ligands on their surface. Scientists from the German Cancer Consortium (DKTK) have now shown that different types of cancer possess different quantities of PD-L1-Gen copies. Genetic analysis of the PD-L1 gene may in the future help to…

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News • Breast cancer

Device allows 3D imaging with less radiation

Preliminary tests have demonstrated that a new device may enable existing breast cancer imagers to provide up to six times better contrast of tumors in the breast, while maintaining the same or better image quality and halving the radiation dose to patients. The advance is made possible by a new device developed for 3D imaging of the breast by researchers at the Department of Energy's Thomas…

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News • Virology

Tricks of ticking time bomb Hepatitis B virus

Hepatitis B virus (HBV) causes hepatitis B, an infectious disease that afflicts 230 million people worldwide, thereof 440 000 in Germany. Persistence of the virus in liver cells leads to progressive organ damage in the patient and contributes to a high risk of cirrhosis and liver cancer development. Providing a new paradigm to hepatitis B understanding, researchers at the German Cancer Research…

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News • Regenerated Bone

Living bone replicates original anatomical structure

A new technique developed by Gordana Vunjak-Novakovic, the Mikati Foundation Professor of Biomedical Engineering at Columbia Engineering and professor of medical sciences (in Medicine) at Columbia University, repairs large bone defects in the head and face by using lab-grown living bone, tailored to the patient and the defect being treated. This is the first time researchers have grown living…

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News • Mutation

Prevention of genetic breast cancer within reach

An international team led by researchers at the Austrian Institute of Molecular Biotechnology (IMBA) in Vienna and the University of Maryland School of Medicine in Baltimore discovered that genetically determined breast cancer can be largely prevented by blocking a bone gene. An already approved drug could be quickly available and would then be the first breast cancer prevention drug.

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News • vitiligo

Natural killer cells have a memory

Researchers at the University of Bonn and the Ludwig-Maximilians-Universität of Munich have decoded a new mechanism of how the immune system can specifically attack pigmented cells of the skin. It was previously believed that natural killer cells did not have an immunological memory for the body's own tissues. However, the scientists have now showed that these immune cells can indeed…

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More light on cancer

The group of Russian and French researchers, with the participation of scientists from the Lomonosov Moscow State University, has succeeded to synthesize nanoparticles of ultrapure silicon, which exhibited the property of efficient photoluminescence, i.e., secondary light emission after photoexcitation. These particles were able to easily penetrate into cancer cells and it allowed to use them as…

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News • Targeted treatments

Gene therapy against brain cancer

A team from the International School for Advanced Studies (SISSA) in Trieste has obtained very promising results by applying gene therapy to glioblastoma. Tests in vitro and in vivo on mice provided very clear-cut results, and modelling demonstrates that the treatment targets at least six different points of tumour metabolism. Gene therapy, a technique that selectively attacks a tumour, might…

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Article • Moving on

I saw the future of pathology – and it’s digital

Healthcare is going digital. No doubt about it, Prof. Hufnagl predicts. Information and communication technologies have gone beyond moving data from one place to the other; they are triggering stellar improvements in healthcare: diagnoses are becoming ever more precise, therapies ever more personalised. The extent to which the individual clinical disciplines have progressed in their technological…

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Article • Datasets

Benefits from The Cancer Genome Atlas

Last year, scientists at the University of California San Francisco (UCSF) revealed that by measuring the proportion of both immune and cancerous cells in tumours, or ‘tumour purity,’ clinicians could more precisely predict the success of certain precision therapies. A key aspect of the discovery was access to over 10,000 samples constituting 21 different cancers.

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Article • Molecular profile

Revealing cancer at a minuscule level

Since the introduction of targeted therapies in oncology the task of the pathologist has expanded beyond histological diagnostics: today, the pathologist analyses tumour tissue samples to establish a molecular profile with tumour cell characteristics – which in turn become the targets of medication.

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News • Breakthrough

Gut bacteria drive growth of stem cells in colon cancer

Colon cancer is one of the most common forms of cancer in Germany. Prof. Dr. med. Sebastian Zeißig, group leader at the DFG Research Center for Regenerative Therapies Dresden (CRTD) - Cluster of Excellence at the TU Dresden and physician at the Department of Medicine I, University Hospital Carl Gustav Carus Dresden, has now shown a decisive role of gut bacteria in the regulation of intestinal…

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News • Lung cancer

“Liquid biopsy” blood test detects genetic mutations

A simple blood test can rapidly and accurately detect mutations in two key genes in non-small cell lung tumors, researchers at Dana-Farber Cancer Institute and other institutions report in a new study – demonstrating the test’s potential as a clinical tool for identifying patients who can benefit from drugs targeting those mutations.

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News • PIK3CA

Cancer drug could treat blood vessel deformities

A drug currently being trialled in cancer patients could also be used to treat an often incurable condition that can cause painful blood vessel overgrowths inside the skin, finds new research in mice led by UCL, Memorial Sloan Kettering (MSK) Cancer Center in New York and the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona.

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News • Small cell lung cancer

Clues to the cause of chemoresistance discovered

Small cell lung cancer is not usually detected until it is at an advanced stage, when metastases have already formed. Chemotherapy is very effective initially but, within a year, cancer recurs and this time does not respond to a course of chemotherapy. The research group headed by Gerhard Hamilton, University Department of Surgery at MedUni Vienna, has now managed to identify the reason for this…

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News • MOZART

Imaging cells and tissues under the skin

Scientists have many tools at their disposal for looking at preserved tissue under a microscope in incredible detail, or peering into the living body at lower resolution. What they haven't had is a way to do both: create a three-dimensional real-time image of individual cells or even molecules in a living animal.

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News • Skin Cancer

The Netherlands' first user of Elekta's Esteya Electronic Brachytherapy

On March 3, Radiotherapy Group clinicians at Ziekenhuis Gelderse Vallei (Ede, the Netherlands) used their Esteya electronic brachytherapy system for the first time to treat a 73-year-old male patient with a nodular basal cell carcinoma on his nose. Esteya is a form of high dose rate (HDR) brachytherapy that applies high-precision radiotherapy directly to the cancer site, minimizing radiation to…

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News • Research

A pill could improve breast cancer diagnoses

The ongoing debate about breast cancer diagnostics has left many women confused — particularly over what age they should get mammograms and who needs treatment. An issue with current methods is that they often identify lumps but cannot conclusively pinpoint which ones are cancerous. To help resolve this uncertainty, researchers have developed a pill that could improve imaging techniques so that…

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Article • EIBALL

Biomarkers increase impact on imaging

‘In imaging there is a trend towards quantification,’ said Professor Siegfried Trattnig, Medical Director of the High-Field MR Centre (HFMRC) at the Medical University Vienna, Austria. Whilst before, radiologists’ findings were subjective, qualitative results, based on signal intensity and grey scale, he pointed out. ‘Today imaging can draw on quantifiable and comparable parameters with…

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Article • HR-CT

A fan of pattern analysis

Interstitial lung diseases (ILD) are rare – yet they are far more difficult to diagnose and highly variable. Professor Julien Dinkel, consultant at the Institute of Clinical Radiology, Ludwig Maximilian University Hospital in Munich, deals with these rarities.

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News • Diabetes

No more Insulin injections?

In patients suffering from Type 1 diabetes, the immune system attacks the pancreas, eventually leaving patients without the ability to naturally control blood sugar. These patients must carefully monitor the amount of sugar in their blood, measuring it several times a day and then injecting themselves with insulin to keep their blood sugar levels within a healthy range. However, precise control…

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News • Fighting cancer

Stopping tumour cells killing surrounding tissue

Tumours kill off surrounding cells to make room to grow, according to new research from the University of Cambridge. Although the study was carried out using fruit flies, its findings suggest that drugs to prevent, rather than encourage, cell death might be effective at fighting cancer – contrary to how many of the current chemotherapy drugs work.

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News • Nuclear medicine

Eckert & Ziegler expands cooperation program with drug developers

Eckert & Ziegler AG, a specialist for isotope-based applications in medicine, science and industry, is expanding its cooperation program with promising drug developers in the field of nuclear medicine and will support Curasight, a spin-off based on research by the group of Professor Andreas Kjaer at the National University Hospital (Rigshospitalet) and University of Copenhagen, in obtaining…

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Cancer cells poised for growth when opportunity knocks

Researchers have identified a mechanism that allows cancer cells to respond and grow rapidly when levels of sugar in the blood rise. This may help to explain why people who develop conditions in which they have chronically high sugar levels in their blood, such as obesity, also have an increased risk of developing certain types of cancer.

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News • Accuray

First radiation therapy systems installed in Latvia and Bulgaria

Accuray Incorporated announced today that the first centers in Qatar, Latvia, and Bulgaria are now equipped with its radiation therapy technology, demonstrating continued momentum in adoption of its devices in Europe, India, the Middle East and Africa (EIMEA). The CyberKnife® and TomoTherapy® Systems are now used in more than 40 countries to treat patients across the full spectrum of radiation…

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News • MRI

Metamaterials boost sensitivity

A group of researchers from Russia, Australia and the Netherlands have developed a technology that can reduce Magnetic Resonance Imaging (MRI) scanning times by more than 50 percent, meaning hospitals can drastically increase the number of scans without changing equipment. This extraordinary leap in efficiency is achieved by placing a layer of metamaterials onto the bed of the scanner, which…

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News • Fluorescent agent

Injectable agent illuminates cancer during surgery

Doctors at the Duke University School of Medicine have tested a new injectable agent that causes cancer cells in a tumor to fluoresce, potentially increasing a surgeon’s ability to locate and remove all of a cancerous tumor on the first attempt. The imaging technology was developed through collaboration with scientists at Duke, the Massachusetts Institute of Technology (MIT) and Lumicell Inc.

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Gene variation promotes uncontrolled cell division

Mom’s eyes and dad’s tumor? Cancer is due to genetic defects, some of which can be hereditary. The gene variant rs351855, for example, occurs in one in two cancer patients. A team headed by Axel Ullrich from the Max Planck Institute of Biochemistry in Martinsried identified the gene variant a decade ago. Now, they succeeded for the first time in showing that the variation exposes an otherwise…

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Article • Bladder

Effectiveness, safety and cost of fluorescence cystoscopy

Bladder cancer is associated with high recurrence rates, necessitating prolonged surveillance and repeated treatments. As a result, it is one of the most challenging and costly of all solid tumours to manage. Although most patients present at an early stage with non-muscle-invasive bladder cancer (NMIBC), between 13% and 61% will experience recurrence within 1 year of initial transurethral…

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Article • Scanner

The world’s first digital clinical path lab

The field is so new that the annual Digital Pathology Congress (3-4 December in London) was held for only the second time. Yet, Philips Healthcare could announce a world-first – in partnership with the Netherlands-based LabPON, the company has created the first clinical pathology laboratory to be completely converted to digital diagnosis.

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Treating colon cancer with vitamin A

A leading cause of cancer deaths worldwide, colon cancer is famously resistant to treatment. There are many reasons for this, but one has to do with a group of persisting cancer cells in the colon that cause relapses. Conventional therapies against them are mostly ineffective. EPFL scientists have now identified a biological mechanism that can be exploited to counteract colon cancer relapses.

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Article • Diagnostic

SuperSonic reveals micro vessels with AngioPLUS

Building on an innovative ultrasound technology that continues to yield break-through capabilities, SuperSonic Imagine is introducing AngioPLUS, a third diagnostic functionality for its Aixplorer platform that promises to be instrumental in the diagnosis of cancerous tissues as well as musculoskeletal pathologies.

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Sugar-coated nanoworms not for breakfast in human immune system

Iron nanoparticles injected before magnetic resonance imaging can make tissues more visible and the same nanoparticles may allow doctors to precisely target tumors with new medicines. However, among the challenges to the practical use of nanoparticles in the human body is what scientists refer to as lack of “hemocompatibility” – nanoparticles tend to be attacked and cleared by the immune…

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News • State-of-the-art

First pictures of cells' DNA-copying machinery

The first-ever images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view. The electron microscope images, created by scientists at the U.S. Department of Energy's Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular…

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Sponsored • Fast. Precise. Sharp.

Superb Microvascular Imaging and more…

Impacting on clinical decisions. Accelerating clinical routine. Following the release of its new Version 6 software upgrade for the Aplio Platinum Series ultrasound system, Toshiba has received high marks for the enhanced functions and performance from practitioners, each offering specific insights into how they are applying the technology.

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News • Lung Metastasis

Subpopulation of white blood cells stands guard

One goal of immunotherapy is to rally a patient’s often over-burdened immune cells to effectively attack a tumor. Among foot soldiers on the immune front line is a subpopulation of white blood cells called “patrolling monocytes,” whose job is to cruise the bloodstream, cart off cellular debris, and block invasion of a less benign population of inflammatory cells.

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News • Cancer care

Swedish healthcare region invests in digital pathology from Sectra

The Swedish healthcare Region Östergötland is making a full commitment to digital pathology by investing in a solution from Sectra for storage, review and sharing of digital pathology images. The aim of the region’s investment is more rapid care for cancer patients, in which pathology has a key role in diagnosis and treatment.

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News • Hematology

Flowing toward red blood cell breakthroughs

A team of researchers from Brown University, ETH Zurich, the Universita da Svizzera Italiana (USI) and Consiglio Nazionale delle Ricerche (CNR) is using America’s most powerful supercomputer to help understand and fight diseases affecting some of the body’s smallest building blocks.

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News • High Throughput WSI

New scanner for double sized slides

In the field of cancer diagnostics often tissue has to be cut in small pieces to fit on standard slides, although larger tissue sizes would be advantageous for diagnosis.In addition, most high throughput scanners available on the market are only able to scan normal sized slides. Some single slide scanners are able to process double sized slides but there is no system available for the automated…

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News • See trough bones

Uncover new details about blood-forming stem cells

A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has become the first to use a tissue-clearing technique to localize a rare stem cell population, in the process cracking open a black box containing detailed information about where blood-forming stem cells are located and how they are maintained. The findings provide a significant advance toward understanding…

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News • Breakthrough

Cell discovery offers new strategy to attack cancer

University of Virginia School of Medicine researchers have discovered a new strategy for attacking cancer cells that could fundamentally alter the way doctors treat and prevent the deadly disease. By more selectively targeting cancer cells, this method offers a strategy to reduce the length of and physical toll associated with current treatments.

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News • Microgravity

Keeping cells in good shape

People often talk about how important it is to stay in shape, something humans usually can accomplish with exercise and a healthy diet, and other habits. But chances are, few of us ever think about the shape of our individual cells.

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News • Study

Spheroid stem cell production sows hope for IPF treatment

In a small pilot study, researchers from North Carolina State University have demonstrated a rapid, simple way to generate large numbers of lung stem cells for use in disease treatment. This method of harvesting and growing a patient’s own lung stem cells shows promise in mice for treating idiopathic pulmonary fibrosis (IPF), and could one day provide human IPF sufferers with an effective, less…

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News • mTOR

Cells in limbo hold clues for tackling cancer and ageing

For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it’s a cellular pathway that’s found in everything from yeast to mammals. mTOR (as it’s called in mammals) plays a central role in instructing the cell to grow and divide in response to nutrients. When it’s turned down, the cell shifts into a second, tidying mode,…

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Article • Tissue definition

PET/MR is promising

PET/MR has long been studied for oncology but the technique also holds promise in cardiovascular applications, according to a panel of experts at the recent International Conference on Nuclear Cardiology and Cardiac CT (ICNCT).

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Real-time data for cancer therapy

In the battle against cancer, which kills nearly 8 million people worldwide each year, doctors have in their arsenal many powerful weapons, including various forms of chemotherapy and radiation. What they lack, however, is good reconnaissance — a reliable way to obtain real-time data about how well a particular therapy is working for any given patient.

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News • Therapy

Approach to reverse kidney damage

Adults who are worried or terrified sometimes curl up into a fetal position. Likewise, adult cells that are injured, including genetic injury leading to cancer, initiate a process that was present during embryonic development.

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Article • Multi-parametric MRI

Prostate MRI: “Yes, we scan!”

One in six men will develop prostate cancer. It is the second leading cause of cancer death amongst men in both the US and the EU. Definite diagnosis at an early stage is vital for survival and early treatment minimizes the risk of adverse effects, such as incontinence, erectile dysfunction, or impotence. While there is no preventive screening there is a ray of hope. Prof. Jelle Barentsz,…

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News • Siemens Computed Tomography

40 Years at the cutting edge of technological development

40 years after the launch of its first series model, Siretom, Siemens Healthcare is looking back on the successful development of its computed tomography division. With innovations such as Spiral, Multislice, and most recently Dual Source technology, Siemens has been driving the CT market and clinical diagnostics for decades. Today, three patients are scanned with a Siemens CT system every…

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News • Swiss Army Knife for Laboratories

Liquid Chromatography Tandem Mass Spectrometry

During the past 15 years, liquid chromatography tandem mass spectrometry (LC-MS/MS) has evolved into a vital technology used to perform routine tests in many clinical laboratories. Historically, LC-MS/MS had been used primarily by research, pharmaceutical, or commercial laboratories; however, advances in the technology, decreasing costs for basic systems, intelligible software, an increased…

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Article • Prostate radiological

‘We need more feedback’

What you see is what you get - unfortunately, this doesn’t always apply in cancer imaging. Why is it that something which looks conspicuous on an image later turns out not to be a tumour? Why, on the other hand, are things overlooked that later turn out to be cancer? Pathological findings are extremely important to help improve diagnostic precision in radiology. Both disciplines therefore…

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Article • Prostate pathological

A pathologist’s view of prostate diagnostics

Pathology is the gold standard of prostate diagnostics. Whilst the radiologist makes interpretations based on shadows and grey scale values visible on an image, the pathologist has the ‘fait accompli’ under the microscope. Professor Glen Kristiansen, Director at the Institute for Pathology at the University Hospital Bonn, explains why image-guided biopsies also make sense from the…

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Article • Therapy

Molecular imaging mines deeper

The view across the Atlantic – it fills Professor Fabian Kiessling, Chair of Experimental Molecular Imaging at the RWTH Aachen (Rhine-Westphalia Institute of Technology Aachen), with optimism. The USA offers more opportunities for molecular imaging. Only recently, new tracers for Alzheimer’s were accepted as reimbursable in some centres, whilst the development of new diagnostics in Europe…

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Article • Big data

Multiparametric imaging

The vast amounts of data accumulating in breast diagnostics require new methods to extract clinical information in a practical way. When dealing with large amounts of data that is too big or too complex to be analysed with traditional data processing applications, the talk today is of ‘Big Data’. The data volume accumulating in breast diagnostics has become increasingly complex over recent…

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"Pulse" technology may replenish skin's collagen

A team of Tel Aviv University and Harvard Medical School researchers has devised a non-invasive technique that harnesses pulsed electric fields to generate new skin tissue growth. According to their research, the novel non-invasive tissue stimulation technique, utilizing microsecond-pulsed, high-voltage, non-thermal electric fields, produces scarless skin rejuvenation and may revolutionize the…

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News • Gene defects

Cancer brake failure leads to brain cancer

Tumor suppressor genes protect against cancer. Until now, scientists have had to perform complex experiments to detect whether or not a mutation or loss of this gene type does, in fact, cause cancer. Scientists from the German Cancer Research Center (DKFZ) have now used a new gene technology method called CRISPR/Cas9 technology for this detection.

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News • Digital Pathology

Dutch university hospital pioneer in digital pathology with solution from Sectra

University Hospital Utrecht (UMCU) in the Netherlands has invested in a solution from Sectra for storing, viewing and sharing digital pathology images. The solution enables pathologists to review cases for primary diagnostics digitally. This new opportunity significantly increases workflow efficiency and offers enhanced collaboration between pathologists and radiologists at the hospital enabling…

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News • Optical Coherence Tomography

Removing brain tumor safer

Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact — and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a…

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News • RADspeed Pro EDGE

New digital radiography system with extended functionality

Shimadzu, worldwide leading manufacturer of diagnostic imaging equipment, has released the new digital radiography system RADspeed Pro EDGE in 2015 – the year of Shimadzu’s 140th anniversary. The system provides a wide range of functionalities: from tomosynthesis via dual-energy subtraction to modern auto-stitching to support diagnostics in clinical applications.

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Article • Oophorectomy

Leading expert takes stand against prophylactic oophorectomy

“I am very concerned about the impact that Angelina Jolie has on the media,” Walter Rocca, professor of epidemiology and neurology at the Mayo Clinic in Rochester, Minnesota, stated. He wasn’t hinting to Jolie’s acting choices or waifish silhouette, but to the confusion surrounding her decision to remove her ovaries to prevent ovarian cancer. By Mélisande Rouger

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Faster skin biopsies without anesthesia

Universidad Carlos III de Madrid (UC3M) and the Institute for Health Research of the Hospital "Ramón y Cajal" (IRYCIS have patented a new device for performing skin biopsies. With this new tool a skin biopsy can be performed with fewer instruments and the length of the procedure is shortened from thirty minutes to less than five.

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Article • Mutations

Dutch scientists build colon cancer progression model

Scientists from the Hubrecht Institute and the University Medical Center Utrecht (UMC Utrecht) have developed a cell culture model of human colon cancer progression. This model mimics the situation in patients more closely than any other colon cancer model so far. It enables researchers to study processes involved in colon cancer development and find new cancer drugs.

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Article • Radiotherapy

Prostate: Free of cancer after five years

Results from a randomised controlled trial to compare the use of permanent radioactive implants (brachytherapy) with dose-escalated external beam radiotherapy in patients with prostate cancer show that the men who received brachytherapy were twice as likely to be cancer-free five years later. These results presented Professor James Morris, from the Department of Radiation Oncology, Vancouver…

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