© Bonekamp/DKFZ
News • Non-invasive risk assessment
Prostate cancer: avoiding unnecessary biopsies with AI
If a PSA test shows an elevated value, this may be an indicator of prostate cancer. To confirm this suspicion, doctors today first order magnetic resonance (MR) imaging as a further diagnostic test.
The "multiparametric MRI" used here combines various imaging techniques and therefore provides very detailed images. However, final certainty can only be obtained by taking tissue samples from the prostate. "Biopsies are invasive and in rare cases can lead to infections or bleeding, sometimes even requiring hospitalization," says David Bonekamp, radiologist at the DKFZ. Doctors are therefore urgently looking for ways to improve risk prediction. "Our aim is to filter out those men who only have a minimal risk of cancer. They could be spared tissue removal or postpone it for a certain period of time. Men with a high probability of prostate cancer, on the other hand, benefit from the biopsy, as the cancer can be detected early," says Bonekamp.
Recommended article
Article • Research, diagnostics, therapy
Focus on prostate cancer
Prostate cancer (PCa) is not only one of the most common, but also one of the deadliest types of cancer in men. Diagnostics are correspondingly sophisticated, from imaging via ultrasound or MRI to various biopsy techniques – often even in combination. Keep reading for current developments in early detection, staging, therapy and research.
Today, researchers use a calculator to estimate the risk of prostate cancer, which takes into account various parameters such as PSA value, age and prostate volume as well as the MRI findings. To this end, doctors use a system known as PI-RADS for the systematized evaluation of MRI images, which ultimately provides a probability value for the presence of prostate cancer.
Could a deep learning-based AI further improve this prediction or possibly even replace PI-RADS? To test this, Bonekamp's team launched a retrospective study in which they included data from 1627 men who had undergone multi-parametric MRI imaging of the prostate in Heidelberg between 2014 and 2021 and subsequently underwent a biopsy.
The researchers published their findings in the journal European Radiology.
The combination of deep learning and radiological findings could theoretically have avoided almost half of these biopsies without overlooking a relevant number of tumors
Adrian Schrader
An algorithm developed at the DKFZ for evaluating image data was trained with the MRI images of over 1000 of these men. Using the remaining 500 or so data sets, the researchers tested whether a combination of their risk calculator with the AI could improve the accuracy of prostate cancer prediction. If the PI-RADS value in the risk calculator was replaced by the AI method, the diagnostic significance hardly changed. In contrast, the combination of AI and PI-RADS delivered significantly better results: It identified 49% as minimal risk among men who had originally been biopsied. "This means that the combination of deep learning and radiological findings could theoretically have avoided almost half of these biopsies without overlooking a relevant number of tumors," says Adrian Schrader from the DKFZ, first author of the current study.
The radiologists conclude from this result that deep learning-based AI and PI-RADS assessment by experienced radiologists evidently provide complementary diagnostic information, which together contribute to a more precise risk stratification of patients. "For patients with an elevated PSA value, it could be a great advantage in the future to integrate AI analysis into further diagnostics. However, prospective studies must confirm the benefits of the procedure and clarify that it has no disadvantages for patients," says Bonekamp.
Source: German Cancer Research Center
08.08.2024
