More consistent TIL assessments, more accurate patients' prognoses: New research shows how AI sharpens pathologists' interpretation of tissue samples for malignant melanoma.
A new technique called photoacoustic computed tomography (PACT) offers a breast imaging alternative without the discomfort, high costs, or risk associated with the conventional evaluation methods.
Molecular profiling of over 1,000 nasopharyngeal cancer (NPC) tumours reveals distinct differences in tumour microenvironment of locoregionally advanced NPC, supporting personalised treatment.
A research team at the University of Geneva has identified two new proteins that regulate gene expression, a discovery that could pave the way for new cancer and brain disorder treatments.
New research makes a strong case for a new dual-targeting radiopharmaceutical, designed to attach to two vulnerable sites on cancer cells, enabling more precise and potent therapy.
Newly developed technology can detect breast cancer relapses up to five years in advance. This advance could represent a turning point in post-treatment follow-up, the researchers hope.
In a new study, researchers have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells, to uncover a new therapeutic possibility for limiting breast cancer spread.
A new ‘liquid biopsy’ test can help fast-track lung cancer patients to receive targeted therapy up to two weeks earlier, while helping avoid further tests and treatments including chemotherapy.
Using nine different molecular biological technologies, researchers were able to precisely measure the properties of a melanoma tumor in four weeks and enable a precise treatment decision.
Tongue squamous cell carcinoma, the most common type of oral cancer, is a challenging target for immunotherapies. Researchers now identified five immunotypes to better predict treatment response.
A major challenge in cancer genomics is separating meaningful mutations from false positives. A new tool uses machine learning to significantly reduce these errors.
Childhood cancer diagnosis times span from immediate to delays of several years, according to a new study. Young bone tumor patients are among the most affected by these delays.
A US research team has shown that Sars-CoV-2 can “reprogram” pathogen-fighting white blood cells into immune system suppressing cells — a potential mechanism by which severe Covid may arise.
With the introduction of boron neutron capture therapy (BNCT), Helsinki University Hospital offers a new radiation therapy method that can destroy cancer cells while sparing the surrounding tissue.
Does having blood type A increase the risk of breast cancer? A new systematic review and meta-analysis involving more than 13,000 breast cancer patients suggests a connection.
Results of a new retrospective study demonstrate the potential of a novel, CT-based deep learning-driven tool to enhance liver cancer diagnosis, treatment planning, and response evaluation.
At the San Antonio Breast Cancer Symposium (SABCS), three experts presented new approaches and study results for the treatment of breast cancer in young women.
Using AI and extensive analyses of gene activity in tumours, researchers have found new, precise biomarkers to diagnose prostate cancer at an early stage through a simple urine sample.
A new approach enables the detection of even trace amounts of cancer cells. The method leverages SERS for signal amplification, eliminating the need for fluorescent dyes.
The incidence of colorectal cancer in young adults has doubled over the last 20 years, with no known reason. Now, a new study links this mysterious trend to childhood exposure to a bacterial toxin.
Molecular testing provides a more convenient, personalized way of monitoring of heart transplant recipients, according to insights shared at the Annual Meeting and Scientific Sessions of the ISHLT.
Using an advanced PET scanner, US radiologists explore how cancer, neurodegenerative diseases and other systemic conditions, can affect the brain by assessing the impact on the blood-brain barrier.
Dutch researchers have developed an AI tool to support Mohs surgery, a precise but time-consuming procedure to treat the most common form of cancer in the Netherlands: basal cell carcinoma.
Unprecedented insights into the inner workings of an early-stage lung tumor: An international research team describes a new method for 3D mapping cellular interactions in the tumor microenvironment.
A newly discovered type of cells counteract tumor development and may therefore be a target for research into new treatments for pancreatic cancer, which is one of the deadliest forms of cancer.
Radiation therapy is an effective component of many cancer treatments, but some patients experience severe side effects. A new study shows that hyperbaric oxygen therapy can provide long-term relief.
Breast MRI has emerged as a powerful diagnostic tool, particularly for women with dense breast tissue where traditional mammography faces limitations. In her presentation at ECR 2025, radiographer Hanna Kalliomäki highlighted several technological advances transforming breast cancer detection and diagnosis. From time-saving abbreviated protocols and AI-assisted analysis to contrast-free…
Pancreatic cancer is one of the most aggressive cancers, partly due to its tumor microenvironment, known as the stroma. Now, a study has identified a new key factor contributing to this feature.
Nuclear medicine (NM), one of the more mature technologies of diagnostic imaging, has been experiencing a rebirth in innovation and interest. The increasing prevalence of cancer,, an aging global population, and greater longevity, has created a robust demand for nuclear medicine. At ECR in Vienna, presenters explored market perspectives, but also safety and sustainability challenges.
Researchers developed biomimetic materials inspired by lymph nodes, which could improve cancer immunotherapy. The study highlights the potential of bioengineered scaffolds for cell-based therapies.
New research reveals a method that uses pulsed infrared light to identify molecular profiles in blood plasma that could indicate the presence of certain common cancers.
Fighting pancreatic cancer can feel like a race against time. A new discovery could give clinicians a head start - by targeting precancerous lesions before they become much more aggressive.
A new method to quickly and accurately analyze the structure of collagen in tissue shows promise to improve the diagnostics of cancer and other diseases.
Researchers discovered a key mechanism by which melanomas and other aggressive tumours prevent the immune system from detecting and attacking them – one of the greatest challenges in oncology today.
The location and timing of breast cancer recurrence may allow AI to predict the risk of metastasis, a new study shows. This is an essential step towards developing personalised treatment strategies.
Nuclear medicine specialists have successfully used the radiopharmaceutical Ga-68-Trivehexin from Trimt to accurately diagnose patients with pulmonary fibrosis and concurrent lung cancer.
Cryoablation, the destruction of malignant cancer cells by freezing them, is increasingly becoming an alternative to having conventional lumpectomy for patients diagnosed with early-stage, localised, low-risk breast cancer. Findings from numerous recent clinical trials show that cancer recurrence rates are very low and are comparable to breast conservation surgery (BCS).
New research reveals that self-generated electrical activity of small cell lung cancer (SCLC) directly promotes tumor metastasis and progression. This may provide new avenues for future treatments.
For patients, a liquid biopsy which checks for circulating tumour DNA of colon cancer, resembles a standard blood test. However, the method helps avoid chemotherapy for many, a new study finds.
Japanese researchers have developed magnetic nanoparticles that can be directed to tumors using a magnet and then heated with a laser to destroy cancer cells while sparing healthy tissue.
New research uncovers the hidden diversity of adrenal gland tumors, shedding light on how they cause unusual medical symptoms and paving the way for new drug treatments.
A new AI-enhanced technique makes breast cancer tissue “glow” on MRI scans. This not only improves breast cancer detection but also can help treat it more effectively, the researchers say.
Research on biliary tract cancer is advancing rapidly, ranging from targeted treatments to new drugs. However, the delivery of these advances to patients is lagging behind, new European studies find.
New research highlights the potential of circulating tumor DNA (ctDNA) analysis as a non-invasive method to identify actionable biomarkers for breast cancer, enabling individualized therapies.
The gastrointestinal microbiome holds valuable information that can help predict whether immunotherapy will be successful against melanoma. A new “gut-on-a-chip” is designed to do exactly that.
Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting the aggressiveness of meningioma brain tumors and breast cancers.
Researchers have created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.
When multiple myeloma cancer cells break out and multiply outside the bone marrow, a wide variety of tumor cells arise, accompanied by a significantly altered immune response, new research shows.
Researchers have developed a new kind of tumour-on-a-chip, which gives insight into the tumour environment and immunotherapy response. The device has been successfully tested on breast cancer samples.
Certain gene alterations can serve as a prognostic and predictive biomarker for prostate cancer. Now, researchers confirm the feasibility of using NGS on this marker for precise patient stratification and treatment selection.
Persister cells arise as a result of cancer treatment and are often responsible for tumour relapse. Researchers identified a distinctive feature of persister cells, paving the way for new treatments.
“What is a tumour?” Researchers explore tumour architecture as a valuable source of information to understand tumour dynamics and predict its sensitivity to anticancer drugs.
Infection with the human papillomavirus (HPV) is the most common cause for cervical cancers. Now, researchers have developed a promising therapeutic vaccine against precancerous lesions.
Senescent cells, which may appear after chemotherapy or radiotherapy, can jeopardize patients' recovery. A study describes a new mechanism to eliminate these cells in cancer patients.
The immune system of children reacts differently to cancer than that of adults. New insights into these differences have the potential to lead to new tailored treatments for children with cancer.
The installation of a state-of-the-art digital PET/CT scanner in Essen marks the German debut for the technology of United Imaging. The device is designed to deliver precision diagnostics at the Kliniken Essen-Mitte Evang and the private nuclear medicine clinic Nukmed, a premier cancer care institution.
Researchers have developed an artificial intelligence (AI) model to detect the spread of metastatic brain cancer using MRI scans, offering insights into patients’ cancer without aggressive surgery.
Steam eliminates wrinkles and germs, but can it destroy cancer cells too? A multisite clinical trial explores the potential of a water vapor system using steam to kill prostate cancer cells.
A new study measured how well breast cancer patients’ tumour ‘explants’ respond to chemotherapy or HER2 antibody therapy in the laboratory. This could help improve clinical outcomes.
By analysing the largest collection of whole-genome data from osteosarcoma patients, researchers identified a driving mechanism behind the aggressive development of these bone cancer tumours.
A new personalised oncology platform has been tested to detect circulating tumour DNA (ctDNA) in patients with lung adenocarcinoma before surgery, to predict their risk of cancer relapse.
Light can change biological processes and affect health. For example, new research finds that red light can lower rates of blood clots that can cause heart attacks, lung damage and strokes.
Why does radiation therapy kill cancer cells from the same tumour in different ways? This has long remained poorly understood. Now, new findings open up opportunities to improve treatment.
Tongue cancer cells can become resistant to chemotherapy under certain circumstances. Investigating these mechanisms, researchers shed light on promising avenues toward new treatments for this cancer.
A premiere that brings hope for fertility restoration to men who underwent chemotherapy during childhood: Researchers reintroduced cryopreserved immature testicular tissue taken 16 years prior.
Researchers have developed an AI-based model to better predict whether cancer patients will benefit from immunotherapy — using only routine blood tests and clinical data.
Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of breast cancer chemotherapy while reducing its harmful side effects.
A molecule called MR1 (MHC Class I-related Molecule 1) enables a newly-discovered type of T-cells to sense differences in the metabolism that occur when cells become cancerous.
Infections with Salmonella can increase the risk of colon cancer. New research sheds light on how this bacterium can cause this. The findings provide new leads for new treatments.
More than half of cancer patients in whom the cancer spreads beyond the primary site have lung metastases. What makes the lungs such a tempting place for cancer cells? New research may have an answer.
Complex diseases could require complex biomarkers for accurate diagnosis in the years ahead, according to a leading pathologist. In a keynote address to the 36th European Congress of Pathology in Florence, Italy, Professor Manuel Salto-Tellez highlighted this as one of the major future challenges for the discipline. However, he also believes pathologists will sit at the core of modern medicine.
Women with breast implants should regularly attend follow-up care to avoid the risk of "silent" implant ruptures and their long-term complications, experts caution in a new publication.
Researchers now succeeded in making leukemia-specific immune cells less sensitive to the influence of tumor cells, thereby significantly increasing their effectiveness.
A new radiotracer – an injected compound used in PET scans – could help inform doctors that a patients aggressive cancer will not respond to chemotherapy before treatment is given.
In a new study, researchers have shown, for the first time, that a particular form of MRI, called diffusion tensor imaging, is capable of robustly detecting pre-malignant lesions in the pancreas.
A new type of photocurrent-responsive coating has been shown to shorten the bone-to-implant integration time after orthopaedic surgery to just two weeks.
Tumors in female fruit flies grow significantly larger than in male ones, a new study finds. The findings could lead to a better understanding of how the biological sex impacts cancer development.
Treating patients with Hodgkin lymphoma with a different form of chemotherapy shows promise to reduce severe side effects, shorten hospital time and increase likelihood of recovering fertility.
Research offers new insights into harnessing the immune system to combat ovarian cancer. The findings could lead to personalized therapies that target the right patients at the right time.
When women are pregnant and nurse their babies, their bodies change to ensure the health of both mother and child. Researchers now surprisingly find that the intestine also changes completely.
A new way to inhibit the proliferation of Sars-CoV-2 opens up new perspectives in the fight against this coronavirus and other viral diseases that still have no medical treatment.
A new MRI-based imaging technique predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.
In the world of theatre, the ‘deus ex machina’, the god from the machine, is a dramaturgical trick to resolve seemingly unsolvable conflicts. Can artificial intelligence (AI) also be such a universal problem solver for internal medicine? At the Annual Congress of the German Society of Internal Medicine (DGIM), Dr Isabella Wiest explored the potential – and limitations – of AI helpers.
New research has linked having a cerebral stroke to lasting changes in the arteries in the abdomen. The study in animal models with hypertension could lead to new preventative strategies.
US researchers have developed a comprehensive deep learning AI model designed to more accurately identify and classify cells in high-content tissue images.
A research team has found wearable organic x-ray sensors could be the answer towards safer radiotherapy protocols for cancer patients, reducing the debilitating side-effects of the treatment.
A new study shows how inherent variations in a cancer cell and its interactions with its surroundings mould its migration. The findings provide valuable insights into the processes behind metastasis.
New insights into the previously unknown diversity of cancer-associated fibroblasts in basal cell carcinoma, squamous cell carcinoma and melanoma could pave the way for new therapies.
A certain type of cells, called aneuploid epithelial cells, are usually associated with breast cancer. However, new research reveals that they can also be found in healthy women.
A new approach to fight glioblastoma: Swiss researchers have now developed an immunotherapy that not only attacks the brain tumor—it also turns its microenvironment against it.
PET/CT image analysis using artificial intelligence (AI) can predict the occurrence of interstitial lung disease, a serious side effect of immunotherapy in lung cancer, a new study shows.
New research highlights the potential of liquid biopsy in diagnosing pancreatic incidentaloma - lesions which can occasionally signal pancreatic cancer in its earliest stages.
Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.
Skills shortages and digitalization, trends in cardiology and oncology, future prospects in laboratory medicine, and healthy aging – these pressing topics are at the forefront of discussions at this year’s Medica Labmed Forum.
Multiplex imaging can play a critical role in unravelling the tumour microenvironment. The potential and benefits of the emerging approach – a way to extract information from human tissue samples by visualising many more biomarkers than traditional microscopy – was highlighted in presentations during the 36th European Congress of Pathology in Florence, Italy. Speakers also discussed novel…
Hyperbaric oxygen therapy (HBOT) treatments could offer relief to breast cancer patients who experience late toxicities following radiotherapy treatment. To date, the handful of completed clinical trials only produced inconclusive or contradictory results. Therefore, results from the latest trial, named HONEY (Effect of Hyperbaric Oxygen Therapy on Breast Cancer Patients with Late Radiation…
New insights gained from 3D cell cultures of breast and prostate cancer grown on the International Space Station (ISS) National Laboratory could lead to a way to treat not just these but all cancers.
In many cases, metastatic breast cancer is still incurable. To improve the odds, researchers have now analyzed the diversity of metastatic cells and their interactions with their cellular environment.
Tumor cells are notorious for their rapid and uncontrolled division, and many cancer therapies aim to disrupt this. New findings suggest potential applications of apoptosis in blood cancer treatment.
New technology shows promise in protecting an implant against infections from resistant bacteria: By heating up small nanorods of gold with near-infrared light (NIR), the bacteria are killed.
A new method could open new avenues to quick, affordable cancer diagnosis, US researchers report. The method uses ultrathin membranes to capture extracellular vesicles.
A new discovery about how the liver flushes cholesterol from the body could lead to more effective treatments for cardiovascular disease – the leading cause of death worldwide.
A ‘mini-protein’ can deliver radiation doses directly to tumours without harming healthy tissues. The approach shows promise for the treatment of metastatic bladder cancer and other tumours.
New insights into metastasis: Scientists created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells. This could help discover new screening and treatment options.
Immunotherapy has become the most promising strategy for treating several cancers, but its effectiveness is still very uneven. Three researchers explain how research is being done to change this.
A study led by Assistant Professor Masamitsu Sone and Professor Yoshifumi Yamaguchi from Hokkaido University, Japan, has uncovered a crucial gene that enables hibernating Syrian hamsters (Mesocricetus auratus) to prevent cold-induced cell death. The research was published in the journal Cell Death and Disease.
A new study found that measuring circulating tumor cells (CTCs), rare cancer cells shed from tumors into the blood, is a reliable way to predict later treatment response and survival prospects with metastatic prostate cancer.
The study findings of a team from Julius-Maximilians-Universität Würzburg (JMU) in Bavaria, Germany help to broaden the conceptual view on the DNA damage response and to link it more closely with RNA metabolism.
By combining mass spectrometry and mass cytometry imaging techniques, researchers can now dive deeper into tumors and map the metabolism of individual cells in tumor tissue.
Scientists at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue.
Researchers have succeeded in identifying patterns of response to treatment in patients with multiple myeloma using AI tools, which helps to accurately predict the evolution of the tumor.
A newfound molecule, called ACBI3, could potentially lead to new therapies against hard-to-treat cancers, improving outcomes for all patients with cancers caused by KRAS mutations.
A bit more mucus in the nose, a little less air in the gut: Even small changes can be important when planning proton therapy against cancer. A new workflow allows for an adapted irradiation every day.
A new study confirms fibrosis as a prognostic indicator in HER2-negative, the most common breast cancer, and opens the way to antifibrotic drug treatments.
STAb-T, a new form of immunotherapy to treat solid tumours shows therapeutic potential in animal models with non-small cell lung cancer. The new strategy is designed to strengthen the defensive cells.
Researchers identified the genetic background of the previously known but mysterious AnWj blood group antigen. The findings allow identification and treatment of patients lacking this blood group.
Only 20-40% of patients respond positively to immunotherapy, and these rates vary across different types of cancer. Researchers now identified five key factors that determine response and survival.
Currently, it is difficult to predict whether a cancer patient will respond to immunotherapy or not. A new method to quantify the heterogeneity of the tumour microenvironment aims to improve this.
Researchers have identified fibrotic scarring as a key source of resurgence of glioblastoma multiforme (GBM). The new insights could lead to better prevention of this type of brain cancer.
A US-Swiss team leverages AI and molecular simulations to uncover new pathways for precision cancer treatments, paving the way for more effective, personalized therapies.
Researchers propose the use of molecular ‘cages’ (made of pseudopeptides) to selectively eliminate cancer cells in acidic microenvironments. This could help reduce side effects from chemotherapy.
A new method of analysing the crystals in dehydrated blood could lead to a quicker, cheaper and less painful technique to diagnose, early detect, and monitor prostate cancer.
Researchers have developed an artificial intelligence which can differentiate cancer cells from normal cells, as well as detect the very early stages of viral infection inside cells.
The time of day can be an important aspect to consider for cancer therapy. Researchers from Charité are developing new methods to use the internal clock inside tumor cells to optimize treatments.
Cologne researchers have developed an AI-based digital pathology platform to enable extremely fast and accurate fully automated analysis of tissue sections from lung cancer patients.
After breast cancer surgery, radiotherapy helps prevent the cancer from returning. However, this protection does not last forever. A long-term study shows the duration of the treatment's benefits.
Can a look at a patient's DNA predict progress of their colorectal cancer? Findings from a new study could lead to improved possibilities for individualised therapies.
A new type of contrast agent for use in both MRI and PET imaging has the potential to significantly enhance diagnosis and subsequent treatment, particularly for kidney diseases and tumors.
Metastases, but no sign of the original tumor: A large international study shows how this phantom cancer can nevertheless be treated.
Dermatologists could benefit from a new algorithm that can help recognize patients with a highly aggressive form of basal cell carcinoma (BCC) of the face.
Researchers discovered islands of highly potent immune cells in the vicinity of glioblastomas. This may open up prospects for new therapies for these aggressive brain tumours.
Researchers at MIT and ETH Zurich developed an AI model that identifies certain breast cancer stages likely to progress to invasive forms of cancer.
Researchers have discovered an Achilles heel of migratory metastatic cells: They now investigate how the cell death mechanism ferroptosis can be utilized for future cancer treatments.
New research reveals a promising approach to developing a universal influenza vaccine that confers lifetime immunity against an evolving virus considered most likely to trigger the next pandemic.
Using genomic sequencing data, researchers have created personalised simulations of individual patients that can quantify the impact of genetic mutations on cancer cell behaviour.
Ductal Carcinoma in Situ (DCIS) often develop into more invasive forms of breast cancer. To predict which DCIS patients are likely to be affected, researchers have developed an analytic AI-based tool.
Microproteins hold great promise, according to new research: Since they are only expressed by liver tumor cells, the proteins could serve as a potential target for cancer vaccine development.
A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.
Why does the immune system sometimes fail to control the development of bowel cancer? UK and Dutch researchers discovered how cancer cells use a genetic "switch" to evade detection.
Why does obesity increase the risk of cancer and possibly metastasis? Researchers in Spain are currently investigating this very question.
Researchers at Stanford have demonstrated that conditions in the matrix surrounding pancreatic cancer cells impact whether those cells respond to chemotherapy.
Measuring temperatures in different face regions could be used to earlier detect chronic illnesses, such as diabetes and hypertension. Researchers now show the potential of an AI-based approach.
Smaller kills faster – this is what was previously thought about gold nanoparticles used to fight cancer cells. However, new research reveals a more complex picture of these interactions.
Researchers have developed an AI model that increases the potential for detecting cancer through sugar analyses. The AI model is faster and better at finding abnormalities than current methods.
Finnish researchers discovered a mechanism that wakes up dormant breast cancer cells and demonstrated that preventing the mechanism can significantly improve treatment outcomes in experimental models.
Although the Covid-19 pandemic is behind us, healthcare facilities continue to experience workflow challenges and resource constraints impacting women’s health and a patient’s ability to receive a timely diagnosis. Clinical specialties like breast radiology and cytology are especially susceptible to these issues and continue to experience backlogs, which impact their ability to deliver timely…
Researchers demonstrated how the growth of malignant brain tumours can be greatly decreased by using iontronic technology to continuously administer low doses of cancer drugs.
The IRCCS in Bologna has inaugurated a state-of-the-art integrated PET/CT system. This cutting-edge technology allows for the entire human body to be studied in a single scan, even detecting the smallest tumour cells.
Pancreatic cancer stem cells exploit an antibacterial protein to evade the immune system. Removing this protein could pave the way to more effective immunotherapy, new research suggests.
Acute myeloid leukaemia (AML) is a common type of blood cancer in childhood and can be diagnosed within a few months of life. New research shows that its origins can be traced back to before birth.
A new study used new molecular analyses to unravel the biological mechanisms of pediatric brain tumors and refine their classification.
Immunotherapy increases survival rates in kidney cancer, but does not work for everyone. A research team developed a new method to predict which patients will benefit from it.
Tissue biopsy and liquid biopsy can increasingly be used as complementary or alternative approaches, with advantages and limitations to each. While speakers at the recent 35th European Congress of Pathology in Dublin were quick to highlight that liquid biopsy was not about to replace tissue biopsy, the focus looked at the benefits and challenges of each through the lens of four expert speakers.
Chemotherapy kills cancer cells – but how? New research suggests that the mechanisms are different than previously understood. The finding will have implications for future cancer treatments.
A new study suggests superiority of the novel investigational PET imaging agent ⁶⁸Ga-DPI-4452 (Debio 0328) to standard CT imaging in the context of clear cell renal cell cancer (ccRCC).
Adding a new dimension to pathology: Researchers explore new, deep learning models that can use 3D pathology datasets to make clinical outcome predictions for curated prostate cancer specimens.
Artificial cells to combat cancer: Research groups are working to create synthetic micro-organisms capable of detecting the presence of the disease and delivering anti-cancer therapies.
Blood cancer cells can remain in the blood of AML patients, even after chemotherapy seemed successful. Testing for these residuals before blood cell donation is a vital precaution, a new study finds.
In cancer, cell deterioration can drive progression. A similar process happens in artherosclerosis, new research reveals. This finding could lead to new ways of combatting disease-causing plaque.
Primary ciliary dyskinesia (PCD) is a rare inherited multi-organ condition, which can lead to inflammation of the airways and infections. Now, scientists have found what causes PCD.
Antimicrobial-resistant infections have become a global threat, with an annual death toll of over 1 million. Now, reseachers created a promising vaccine candidate for antibiotic-resistant bacteria.
Stiffness in tissues can be a valuable indicator of cancer formation. Now, researchers have developed a microscopic probe to perform histology at the single cell level inside the human body.
Unlike most tumours, atypical teratoid/rhabdoid (AT/RT) tumours develop very quickly. Now, researchers explored the mechanisms of these aggressive brain tumours that mainly affect young children.
Researchers have discovered how the mechanical properties of tumours - their softness, for example - can prime cancer cells to better survive their spread to other organs.
Findings from the largest UK study of patients hospitalised with Sars-CoV-2 infection show that long Covid leads to ongoing inflammation which can be detected in the blood.
Digital pathology can be used to great effect in pharmaceutical research: it can accelerate analyses, give deeper insights into cellular mechanisms, and enable better understanding of their role into clinical development. This potentially offers clearer predictions on how patients may respond to treatment and lead to personalized therapies.
Bacteria can help – or hinder – the treatment of cancer. How this happens, however, is largely unknown. Now, researchers have mapped bacteria in cancer metastases to shed more light on their role.
A newly-developed material made of proteins shows promise for targeted cancer therapies: Like secretory granules in the endocrine system, it delivers nanoparticles which attack specific cancer cells.
A new trial could pave the way for more gentle surgery of breast cancer: The researchers explore the possibility of sparing the lymph nodes in the armpit - even if metastases are already present.
Osteosarcoma is the most prevalent malignant bone tumor. Now, researchers have developed a machine-learning model to predict the density of viable tumor cells after surgery and chemotherapy treatment.
A study found immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of ‘exhaustion’. This opens new possibilities for cancer prevention.
A new detection tool is designed to contribute to improving tumour research and classification by identification and quantification of chromosomal instability in the nuclei of cancer cells.
A new bioelectronic sensor enables continuous monitoring of bladder function. This could be a game-changer for people with paralysis, spina bifida, bladder cancer or end-stage bladder disease.
A combination of PET and MR imaging could help doctors spot signs that breast cancer is beginning to spread in a patient. This insight can then be used to adapt treatment strategies.
A research team created a computational model that simulates the invasion of cancer cells in breast tumors on a biomechanical level. This could help predict the evolution of breast cancer in patients.
Using 3D bioprinting to accurately replicate the biological environment surrounding gastric cancer cells, researchers predicted a patient’s response to anticancer drugs during the preclinical stage.
In diagnostics, there used to be a hard divide between radiology and pathology, where methods were largely considered incompatible with one another. However, to pave the way for next-generation diagnosis, Professor Regina Beets-Tan urged both sides to come out from their trenches and appreciate the synergies the fields have to offer. In her presentation at the European Congress of Radiology (ECR)…
Biochemists and bioinformaticians from the Leibniz Institute DSMZ have extensively characterized the molecular properties of the breast cancer cell lines from the institute's collection.
Multiplex PET imaging technology could provide a ground-breaking new approach for diagnosing and treating bowel cancer patients, according to scientists in Glasgow.
Researchers have developed the 'iKnife', a smart scalpel that is able to recognise healthy tissue from brain tumour in seconds as it cuts, with more than 98% accuracy.
US oncologists are exploring a new combined chemotherapy and surgical approach to safely remove advanced pancreatic tumors that were previously considered inoperable.
Women with a type of ovarian cancer known as germ cell tumours have a worse prognosis than men with similar tumours. The five-year survival rate was 98% for men, but 85% for women, a new study finds.
A novel AI-based, non-invasive diagnostic tool enables accurate brain tumor diagnosis, outperforming current classification methods. The tool leverages MRI information to aid clinical decision making.
Holding a mobile phone close to the head for an extended amount of time has long been connected to brain cancer. Now, a new study found no hints for an increased risk.
Researchers have now shown that a noninvasive treatment that stimulates gamma frequency brain waves may hold promise for treating memory impairment and other cognitive effects of chemotherapy.
In a breakthrough for personalised oncology, scientists have developed and demonstrated a novel platform that can significantly reduce the time needed to determine the efficacy of anti-cancer drugs.
A team of researchers has discovered a new method of measuring levels of cortisol directly from a blood sample - a significant step forward in diagnosis and treatment of a wide range of diseases.
Artificial Intelligence has helped scientists reveal a new form of aggressive prostate cancer which could revolutionise how the disease is diagnosed and treated in the future.
Researchers have found a surprising method to reduce blood glucose levels in a person: Shining red light on their back. This could help control diabetes without medication.
An innovative solution based on nanotechnology and ultrasound could prevent over-treatment of patients with rectal cancer. The magnetomotive ultrasound system uses nanotechnology for reliable diagnosis of any spread of rectal cancer to nearby lymph nodes.
Breast cancer has no “one size fits all” therapy approach: subtypes differ significantly in malignancy, progression, and treatment response. Therefore, the more is known about the type of carcinoma in a patient, the better the outcome. At the annual scientific EUSOBI meeting in Valencia, Dr Ramona Woitek pointed out the potential of novel imaging techniques and computational image analysis…
A new test to help diagnose Barrett’s oesophagus – a condition that can lead to oesophageal cancer – has reduced the need for invasive endoscopy in thousands of low-risk patients.
A research team created "laboratory testicles" that may significantly advance understanding of the mechanisms involved in sex determination and provide solutions for male infertility.
Chronic stress can have a significant impact on health, from an increased risk for heart disease to a greater susceptibility of cancer metastasis. New research points out the underlying mechanisms.
Cancer patients receiving radiotherapy run the risk of injuring their lungs. This can lead to conditions like pneumonitis and fibrosis. A new cell-by-cell model can help make treatments safer.
Researchers have unveiled a detailed understanding of immune responses in cancer, potentially paving the way for the development of new therapeutic strategies, the team hopes.
Research reveals how a new mechanism could improve the efficiency of current treatments for diabetes. This may open up new ways of approaching metabolic diseases that are a global health problem.
Under certain circumstances, lung tumours can transform into another, more aggressive cancer type. Now, researchers have found a way to illuminate this process, known as histological transformation.
Chemotherapy can be toxic to heart cells. To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional “heart-on-a-chip” to evaluate drug safety.
Targeting a specific protein, Finnish researchers may have found a way to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment.
Ahead of World Cancer Day on 4 February, scientists are revealing a cutting-edge artificial intelligence (AI) tool designed to help grade cancer, by analysing cell division.
AI technology holds promise for personalised cancer therapies. However, rigid and slow approval requirements impede its introduction, say experts – and point out how this might be changed.
Researchers in Japan and the US have developed technology to robustly augment the amount of MHC class I molecules in cancer cells. This makes them easier to find and destroy for the immune system.
Digital pathology brings benefits for sample management and optimisation, lets pathologists work on samples remotely: The UK Government has now approved the use of the technique for cancer samples.
Academic labs and biotech firms pioneer multi-cancer early detection with emerging technologies. Screening for multiple cancers with a simple blood or urinary draw could be a game-changer. Two research teams in particular have advanced the field.
Chemotherapy against cancer can lead to the generation of senescent tumour cells, which can help the tumour survive. A new immunotherapy approach to eliminate these cells shows promise in animal models.
A simple blood test could help diagnose patients with glioblastoma, the deadliest form of brain cancer, sparing them from undergoing invasive and highly-risky surgery, report UK researchers.
Using a unique new technique, US researchers hope to offer a safer and more effective alternative to current cancer treatments, reporting promising first results in mice.
Scientists have pinpointed likely ‘cells-of-origin’, the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease.
New research demonstrates how tiny nanomachines could greatly reduce bladder cancer by precisely targeting the tumour and attacking it with a radioisotope carried on their surface.
Coronavirus vaccines have showcased the possibilities of messenger RNA (mRNA) technology. Now, a research team aims to put it to use against a rare inherited metabolic disorder.
Certain genetic features are crucial for treatment decisions for AML leukaemia. A team from Münster shows how an AI-based method can predict these features from images of bone marrow smears.
An Italian research team has introduced a new MRI-based method for assessing water water exchange to estimate the degree of malignancy and the success of treatments in tumors.
Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.
A research team has successfully developed “NK cell-engaging nanodrones” capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable cancer types.
When your stomach is full after a large meal, certain receptors are activated to tell the brain. A newly developed capsule could provoke this fullness signal early, potentially helping with treating obesity.
It's an important milestone for gene editing technology: a novel treatment for sickle cell disease utilizing CRISPR-Cas9, has now received FDA approval – a first for this type of therapy.
US researchers discuss three blood-based liquid biopsies, namely circulating tumor cells, circulating tumor DNA and tumor-derived exosomes, as they relate to prostate cancer management.
Scientists map the effects of 86 immune-signaling molecules called cytokines on every major immune cell type, creating a reference for studying the inner workings of the immune system.
White blood cells found in breast tumors can both help and hinder the spread of cancer cells to other organs, a new study from Karolinska Institutet shows.
The Covid-19 pandemic has affected scientific research in numerous ways – for example by highlighting knowledge gaps in gender medicine. In many studies differences in morbidity and mortality between women and men surfaced incidentally. While the extent and causes of these differences remain largely unexplored, the preliminary insights confirm the need for further research.
In a new study, UCLA researchers demonstrated how small cell neuroendocrine prostate cancer tumor cells can arise from less aggressive prostate tumors.
Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe Covid-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a Covid-19 infection. This will allow physicians to adjust treatment at an early stage. The researchers used a method…
Using small blood vessels grown in the lab, researchers discover how vascular leaks leading to dementia and stroke emerge – and how this damage might be fixed.
Faster, more accurate and cost-effective testing: Experts outline the beginnings and evolution of “lab-on-a-chip” technology, and its benefits for advanced and next-gen operational platforms.
A multinational study confirms a strong and clear association between exposure to radiation from CT scans in young people and an increased risk of blood cancers.
Pancreatic cancer is not just one disease, but that’s the way it is currently treated. New work from Columbia University could help pave the way for a change.
In a new study, researchers from Fudan University have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.
Inspired by the enhanced visual system of butterflies, researchers have developed an imaging sensor to “see” into the UV range for differentiating between cancer and normal cells.
Bioethics researchers call on medical societies, government leaders, clinicians, and researchers to work together to ensure AI-driven healthcare preserves patient autonomy and respects human dignity.
A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.
Machine learning and AI are playing an increasingly important role in medicine and healthcare, and not just since ChatGPT. This is especially true in data-intensive specialties such as radiology, pathology or intensive care. The quality of diagnostics and decision-making via AI, however, does not only depend on a sophisticated algorithm but – crucially – on the quality of the training data.
A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.
Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. Now, lymphoma specialists in Essen are investigating the possibility of a different approach.
Advances in positron computed tomography (PET) could lead to a more refined approach to the precise removal of brain tumors is on the horizon, experts from Poland point out.
A collaborative study, led by Cima Universidad de Navarra, has identified key epigenetic targets for the treatment of hepatoblastoma, the most frequent liver cancer in childhood.
University of Basel scientists have discovered that high levels of the amino acid arginine drive metabolic reprogramming to promote tumor growth. This could lead to improved liver cancer treatment.
What role should artificial life play in medicine? Researchers from Denmark and the US explore the potential of hybrid peptide-DNA nanostructures for diagnosing and treating diseases.
A team of researchers from Vienna has discovered that dormant breast cancer tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein.
After pelvic radiotherapy, patients may live with low-grade chronic inflammation of the lower intestine 20 years after the treatment, a new study shows.
US researchers have discovered that radiation therapy combined with two types of immunotherapy can control tumors in preclinical models of triple negative breast cancer.
A new class of antibiotics, based on proven drugs used in cancer treatment, is now being developed by researchers at Linköping University. They could be used against resistant bacteria.
A new onco-therapeutic vaccine candidate against human papillomavirus (HPV)-induced cancers, such as cervical and oropharyngeal cancers, has shown promising results in the preclinical phase.
Engineers from MIT are developing a device containing insulin-producing cells and a tiny oxygen-producing factory to keep the cells of diabetes patients healthy.
Chemotherapy can be an effective means to fight breast cancer, but under certain circumstances, the treatment can cause dormant cancer cells to re-awaken, new research finds.
From cancer to AI, from management to new medication: this year's Labmed Forum at MEDICA 2023 in Düsseldorf (November 13-16) once again features an exciting scientific programme.
Basque researchers propose a bioelectronic device consisting of gold electrodes coated with a smart polymer capable of capturing and releasing cells in a non-invasive, controllable way.
Half as thick as a human hair: Researchers at TU Munich have developed the world's first microrobot capable of navigating within groups of cells and stimulating individual cells.
A new nanocomplex renders a tumor harmless – and, on top of that, it trains the immune system to detect and eliminate metastases.
A new type of microdevice could offer new ways to treat brain cancer. The shape and size of a grain of rice, it is implanted into a tumor to study the effects of ongoing therapies.