A US-Swiss team leverages AI and molecular simulations to uncover new pathways for precision cancer treatments, paving the way for more effective, personalized therapies.
Researchers propose the use of molecular ‘cages’ (made of pseudopeptides) to selectively eliminate cancer cells in acidic microenvironments. This could help reduce side effects from chemotherapy.
A new method of analysing the crystals in dehydrated blood could lead to a quicker, cheaper and less painful technique to diagnose, early detect, and monitor prostate cancer.
Researchers have developed an artificial intelligence which can differentiate cancer cells from normal cells, as well as detect the very early stages of viral infection inside cells.
The time of day can be an important aspect to consider for cancer therapy. Researchers from Charité are developing new methods to use the internal clock inside tumor cells to optimize treatments.
Cologne researchers have developed an AI-based digital pathology platform to enable extremely fast and accurate fully automated analysis of tissue sections from lung cancer patients.
After breast cancer surgery, radiotherapy helps prevent the cancer from returning. However, this protection does not last forever. A long-term study shows the duration of the treatment's benefits.
Can a look at a patient's DNA predict progress of their colorectal cancer? Findings from a new study could lead to improved possibilities for individualised therapies.
A new type of contrast agent for use in both MRI and PET imaging has the potential to significantly enhance diagnosis and subsequent treatment, particularly for kidney diseases and tumors.
Metastases, but no sign of the original tumor: A large international study shows how this phantom cancer can nevertheless be treated.
Dermatologists could benefit from a new algorithm that can help recognize patients with a highly aggressive form of basal cell carcinoma (BCC) of the face.
Researchers discovered islands of highly potent immune cells in the vicinity of glioblastomas. This may open up prospects for new therapies for these aggressive brain tumours.
Researchers at MIT and ETH Zurich developed an AI model that identifies certain breast cancer stages likely to progress to invasive forms of cancer.
Researchers have discovered an Achilles heel of migratory metastatic cells: They now investigate how the cell death mechanism ferroptosis can be utilized for future cancer treatments.
New research reveals a promising approach to developing a universal influenza vaccine that confers lifetime immunity against an evolving virus considered most likely to trigger the next pandemic.
Using genomic sequencing data, researchers have created personalised simulations of individual patients that can quantify the impact of genetic mutations on cancer cell behaviour.
Ductal Carcinoma in Situ (DCIS) often develop into more invasive forms of breast cancer. To predict which DCIS patients are likely to be affected, researchers have developed an analytic AI-based tool.
Microproteins hold great promise, according to new research: Since they are only expressed by liver tumor cells, the proteins could serve as a potential target for cancer vaccine development.
A new study shows that extracellular vesicles shed by prostate cancer cells contain tumor-derived material that can be used as biomarkers of therapy response and resistance in metastatic disease.
Why does the immune system sometimes fail to control the development of bowel cancer? UK and Dutch researchers discovered how cancer cells use a genetic "switch" to evade detection.
Why does obesity increase the risk of cancer and possibly metastasis? Researchers in Spain are currently investigating this very question.
Researchers at Stanford have demonstrated that conditions in the matrix surrounding pancreatic cancer cells impact whether those cells respond to chemotherapy.
Measuring temperatures in different face regions could be used to earlier detect chronic illnesses, such as diabetes and hypertension. Researchers now show the potential of an AI-based approach.
Smaller kills faster – this is what was previously thought about gold nanoparticles used to fight cancer cells. However, new research reveals a more complex picture of these interactions.
Researchers have developed an AI model that increases the potential for detecting cancer through sugar analyses. The AI model is faster and better at finding abnormalities than current methods.
Finnish researchers discovered a mechanism that wakes up dormant breast cancer cells and demonstrated that preventing the mechanism can significantly improve treatment outcomes in experimental models.
Although the Covid-19 pandemic is behind us, healthcare facilities continue to experience workflow challenges and resource constraints impacting women’s health and a patient’s ability to receive a timely diagnosis. Clinical specialties like breast radiology and cytology are especially susceptible to these issues and continue to experience backlogs, which impact their ability to deliver timely…
Researchers demonstrated how the growth of malignant brain tumours can be greatly decreased by using iontronic technology to continuously administer low doses of cancer drugs.
The IRCCS in Bologna has inaugurated a state-of-the-art integrated PET/CT system. This cutting-edge technology allows for the entire human body to be studied in a single scan, even detecting the smallest tumour cells.
Pancreatic cancer stem cells exploit an antibacterial protein to evade the immune system. Removing this protein could pave the way to more effective immunotherapy, new research suggests.
Acute myeloid leukaemia (AML) is a common type of blood cancer in childhood and can be diagnosed within a few months of life. New research shows that its origins can be traced back to before birth.
A new study used new molecular analyses to unravel the biological mechanisms of pediatric brain tumors and refine their classification.
Immunotherapy increases survival rates in kidney cancer, but does not work for everyone. A research team developed a new method to predict which patients will benefit from it.
Tissue biopsy and liquid biopsy can increasingly be used as complementary or alternative approaches, with advantages and limitations to each. While speakers at the recent 35th European Congress of Pathology in Dublin were quick to highlight that liquid biopsy was not about to replace tissue biopsy, the focus looked at the benefits and challenges of each through the lens of four expert speakers.
Chemotherapy kills cancer cells – but how? New research suggests that the mechanisms are different than previously understood. The finding will have implications for future cancer treatments.
A new study suggests superiority of the novel investigational PET imaging agent ⁶⁸Ga-DPI-4452 (Debio 0328) to standard CT imaging in the context of clear cell renal cell cancer (ccRCC).
Adding a new dimension to pathology: Researchers explore new, deep learning models that can use 3D pathology datasets to make clinical outcome predictions for curated prostate cancer specimens.
Artificial cells to combat cancer: Research groups are working to create synthetic micro-organisms capable of detecting the presence of the disease and delivering anti-cancer therapies.
Blood cancer cells can remain in the blood of AML patients, even after chemotherapy seemed successful. Testing for these residuals before blood cell donation is a vital precaution, a new study finds.
In cancer, cell deterioration can drive progression. A similar process happens in artherosclerosis, new research reveals. This finding could lead to new ways of combatting disease-causing plaque.
Primary ciliary dyskinesia (PCD) is a rare inherited multi-organ condition, which can lead to inflammation of the airways and infections. Now, scientists have found what causes PCD.
Antimicrobial-resistant infections have become a global threat, with an annual death toll of over 1 million. Now, reseachers created a promising vaccine candidate for antibiotic-resistant bacteria.
Stiffness in tissues can be a valuable indicator of cancer formation. Now, researchers have developed a microscopic probe to perform histology at the single cell level inside the human body.
Unlike most tumours, atypical teratoid/rhabdoid (AT/RT) tumours develop very quickly. Now, researchers explored the mechanisms of these aggressive brain tumours that mainly affect young children.
Researchers have discovered how the mechanical properties of tumours - their softness, for example - can prime cancer cells to better survive their spread to other organs.
Findings from the largest UK study of patients hospitalised with Sars-CoV-2 infection show that long Covid leads to ongoing inflammation which can be detected in the blood.
Digital pathology can be used to great effect in pharmaceutical research: it can accelerate analyses, give deeper insights into cellular mechanisms, and enable better understanding of their role into clinical development. This potentially offers clearer predictions on how patients may respond to treatment and lead to personalized therapies.
Bacteria can help – or hinder – the treatment of cancer. How this happens, however, is largely unknown. Now, researchers have mapped bacteria in cancer metastases to shed more light on their role.
A newly-developed material made of proteins shows promise for targeted cancer therapies: Like secretory granules in the endocrine system, it delivers nanoparticles which attack specific cancer cells.
A new trial could pave the way for more gentle surgery of breast cancer: The researchers explore the possibility of sparing the lymph nodes in the armpit - even if metastases are already present.
Osteosarcoma is the most prevalent malignant bone tumor. Now, researchers have developed a machine-learning model to predict the density of viable tumor cells after surgery and chemotherapy treatment.
A study found immune cells in breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of ‘exhaustion’. This opens new possibilities for cancer prevention.
A new detection tool is designed to contribute to improving tumour research and classification by identification and quantification of chromosomal instability in the nuclei of cancer cells.
A new bioelectronic sensor enables continuous monitoring of bladder function. This could be a game-changer for people with paralysis, spina bifida, bladder cancer or end-stage bladder disease.
A combination of PET and MR imaging could help doctors spot signs that breast cancer is beginning to spread in a patient. This insight can then be used to adapt treatment strategies.
A research team created a computational model that simulates the invasion of cancer cells in breast tumors on a biomechanical level. This could help predict the evolution of breast cancer in patients.
Using 3D bioprinting to accurately replicate the biological environment surrounding gastric cancer cells, researchers predicted a patient’s response to anticancer drugs during the preclinical stage.
In diagnostics, there used to be a hard divide between radiology and pathology, where methods were largely considered incompatible with one another. However, to pave the way for next-generation diagnosis, Professor Regina Beets-Tan urged both sides to come out from their trenches and appreciate the synergies the fields have to offer. In her presentation at the European Congress of Radiology (ECR)…
Biochemists and bioinformaticians from the Leibniz Institute DSMZ have extensively characterized the molecular properties of the breast cancer cell lines from the institute's collection.
Multiplex PET imaging technology could provide a ground-breaking new approach for diagnosing and treating bowel cancer patients, according to scientists in Glasgow.
Researchers have developed the 'iKnife', a smart scalpel that is able to recognise healthy tissue from brain tumour in seconds as it cuts, with more than 98% accuracy.
US oncologists are exploring a new combined chemotherapy and surgical approach to safely remove advanced pancreatic tumors that were previously considered inoperable.
Women with a type of ovarian cancer known as germ cell tumours have a worse prognosis than men with similar tumours. The five-year survival rate was 98% for men, but 85% for women, a new study finds.
A novel AI-based, non-invasive diagnostic tool enables accurate brain tumor diagnosis, outperforming current classification methods. The tool leverages MRI information to aid clinical decision making.
Holding a mobile phone close to the head for an extended amount of time has long been connected to brain cancer. Now, a new study found no hints for an increased risk.
Researchers have now shown that a noninvasive treatment that stimulates gamma frequency brain waves may hold promise for treating memory impairment and other cognitive effects of chemotherapy.
In a breakthrough for personalised oncology, scientists have developed and demonstrated a novel platform that can significantly reduce the time needed to determine the efficacy of anti-cancer drugs.
A team of researchers has discovered a new method of measuring levels of cortisol directly from a blood sample - a significant step forward in diagnosis and treatment of a wide range of diseases.
Artificial Intelligence has helped scientists reveal a new form of aggressive prostate cancer which could revolutionise how the disease is diagnosed and treated in the future.
Researchers have found a surprising method to reduce blood glucose levels in a person: Shining red light on their back. This could help control diabetes without medication.
Breast cancer has no “one size fits all” therapy approach: subtypes differ significantly in malignancy, progression, and treatment response. Therefore, the more is known about the type of carcinoma in a patient, the better the outcome. At the annual scientific EUSOBI meeting in Valencia, Dr Ramona Woitek pointed out the potential of novel imaging techniques and computational image analysis…
An innovative solution based on nanotechnology and ultrasound could prevent over-treatment of patients with rectal cancer. The magnetomotive ultrasound system uses nanotechnology for reliable diagnosis of any spread of rectal cancer to nearby lymph nodes.
A new test to help diagnose Barrett’s oesophagus – a condition that can lead to oesophageal cancer – has reduced the need for invasive endoscopy in thousands of low-risk patients.
A research team created "laboratory testicles" that may significantly advance understanding of the mechanisms involved in sex determination and provide solutions for male infertility.
Chronic stress can have a significant impact on health, from an increased risk for heart disease to a greater susceptibility of cancer metastasis. New research points out the underlying mechanisms.
Cancer patients receiving radiotherapy run the risk of injuring their lungs. This can lead to conditions like pneumonitis and fibrosis. A new cell-by-cell model can help make treatments safer.
Researchers have unveiled a detailed understanding of immune responses in cancer, potentially paving the way for the development of new therapeutic strategies, the team hopes.
Research reveals how a new mechanism could improve the efficiency of current treatments for diabetes. This may open up new ways of approaching metabolic diseases that are a global health problem.
Under certain circumstances, lung tumours can transform into another, more aggressive cancer type. Now, researchers have found a way to illuminate this process, known as histological transformation.
Chemotherapy can be toxic to heart cells. To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional “heart-on-a-chip” to evaluate drug safety.
Targeting a specific protein, Finnish researchers may have found a way to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment.
Ahead of World Cancer Day on 4 February, scientists are revealing a cutting-edge artificial intelligence (AI) tool designed to help grade cancer, by analysing cell division.
AI technology holds promise for personalised cancer therapies. However, rigid and slow approval requirements impede its introduction, say experts – and point out how this might be changed.
Researchers in Japan and the US have developed technology to robustly augment the amount of MHC class I molecules in cancer cells. This makes them easier to find and destroy for the immune system.
Digital pathology brings benefits for sample management and optimisation, lets pathologists work on samples remotely: The UK Government has now approved the use of the technique for cancer samples.
Academic labs and biotech firms pioneer multi-cancer early detection with emerging technologies. Screening for multiple cancers with a simple blood or urinary draw could be a game-changer. Two research teams in particular have advanced the field.
Chemotherapy against cancer can lead to the generation of senescent tumour cells, which can help the tumour survive. A new immunotherapy approach to eliminate these cells shows promise in animal models.
A simple blood test could help diagnose patients with glioblastoma, the deadliest form of brain cancer, sparing them from undergoing invasive and highly-risky surgery, report UK researchers.
Using a unique new technique, US researchers hope to offer a safer and more effective alternative to current cancer treatments, reporting promising first results in mice.
Scientists have pinpointed likely ‘cells-of-origin’, the source cells that can grow into breast cancer, in women carrying a faulty BRCA2 gene who are at high risk of developing the disease.
New research demonstrates how tiny nanomachines could greatly reduce bladder cancer by precisely targeting the tumour and attacking it with a radioisotope carried on their surface.
Coronavirus vaccines have showcased the possibilities of messenger RNA (mRNA) technology. Now, a research team aims to put it to use against a rare inherited metabolic disorder.
Certain genetic features are crucial for treatment decisions for AML leukaemia. A team from Münster shows how an AI-based method can predict these features from images of bone marrow smears.
An Italian research team has introduced a new MRI-based method for assessing water water exchange to estimate the degree of malignancy and the success of treatments in tumors.
Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.
A research team has successfully developed “NK cell-engaging nanodrones” capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable cancer types.
When your stomach is full after a large meal, certain receptors are activated to tell the brain. A newly developed capsule could provoke this fullness signal early, potentially helping with treating obesity.
It's an important milestone for gene editing technology: a novel treatment for sickle cell disease utilizing CRISPR-Cas9, has now received FDA approval – a first for this type of therapy.
US researchers discuss three blood-based liquid biopsies, namely circulating tumor cells, circulating tumor DNA and tumor-derived exosomes, as they relate to prostate cancer management.
Scientists map the effects of 86 immune-signaling molecules called cytokines on every major immune cell type, creating a reference for studying the inner workings of the immune system.
White blood cells found in breast tumors can both help and hinder the spread of cancer cells to other organs, a new study from Karolinska Institutet shows.
The Covid-19 pandemic has affected scientific research in numerous ways – for example by highlighting knowledge gaps in gender medicine. In many studies differences in morbidity and mortality between women and men surfaced incidentally. While the extent and causes of these differences remain largely unexplored, the preliminary insights confirm the need for further research.
In a new study, UCLA researchers demonstrated how small cell neuroendocrine prostate cancer tumor cells can arise from less aggressive prostate tumors.
Researchers have developed a method for assessing the number and structure of aggregated blood platelets (or thrombocytes) that can potentially help quantify the risk of a severe Covid-19 infection. As a result, they have identified a predictive biomarker for the seriousness of a Covid-19 infection. This will allow physicians to adjust treatment at an early stage. The researchers used a method…
Using small blood vessels grown in the lab, researchers discover how vascular leaks leading to dementia and stroke emerge – and how this damage might be fixed.
Faster, more accurate and cost-effective testing: Experts outline the beginnings and evolution of “lab-on-a-chip” technology, and its benefits for advanced and next-gen operational platforms.
A multinational study confirms a strong and clear association between exposure to radiation from CT scans in young people and an increased risk of blood cancers.
Pancreatic cancer is not just one disease, but that’s the way it is currently treated. New work from Columbia University could help pave the way for a change.
In a new study, researchers from Fudan University have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.
Inspired by the enhanced visual system of butterflies, researchers have developed an imaging sensor to “see” into the UV range for differentiating between cancer and normal cells.
Bioethics researchers call on medical societies, government leaders, clinicians, and researchers to work together to ensure AI-driven healthcare preserves patient autonomy and respects human dignity.
A paper published in Trends in Cancer explains the advantages of RENACER, the world’s first repository of brain metastases live samples, created by researchers at CNIO.
Machine learning and AI are playing an increasingly important role in medicine and healthcare, and not just since ChatGPT. This is especially true in data-intensive specialties such as radiology, pathology or intensive care. The quality of diagnostics and decision-making via AI, however, does not only depend on a sophisticated algorithm but – crucially – on the quality of the training data.
A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.
Chemotherapy, radiotherapy or surgery – these are the three common forms of cancer therapy. Now, lymphoma specialists in Essen are investigating the possibility of a different approach.
Advances in positron computed tomography (PET) could lead to a more refined approach to the precise removal of brain tumors is on the horizon, experts from Poland point out.
A collaborative study, led by Cima Universidad de Navarra, has identified key epigenetic targets for the treatment of hepatoblastoma, the most frequent liver cancer in childhood.
University of Basel scientists have discovered that high levels of the amino acid arginine drive metabolic reprogramming to promote tumor growth. This could lead to improved liver cancer treatment.
What role should artificial life play in medicine? Researchers from Denmark and the US explore the potential of hybrid peptide-DNA nanostructures for diagnosing and treating diseases.
A team of researchers from Vienna has discovered that dormant breast cancer tumor cells surviving chemotherapy can be targeted through the inhibition of a specific protein.
After pelvic radiotherapy, patients may live with low-grade chronic inflammation of the lower intestine 20 years after the treatment, a new study shows.
US researchers have discovered that radiation therapy combined with two types of immunotherapy can control tumors in preclinical models of triple negative breast cancer.
A new class of antibiotics, based on proven drugs used in cancer treatment, is now being developed by researchers at Linköping University. They could be used against resistant bacteria.
A new onco-therapeutic vaccine candidate against human papillomavirus (HPV)-induced cancers, such as cervical and oropharyngeal cancers, has shown promising results in the preclinical phase.
Engineers from MIT are developing a device containing insulin-producing cells and a tiny oxygen-producing factory to keep the cells of diabetes patients healthy.
Chemotherapy can be an effective means to fight breast cancer, but under certain circumstances, the treatment can cause dormant cancer cells to re-awaken, new research finds.
From cancer to AI, from management to new medication: this year's Labmed Forum at MEDICA 2023 in Düsseldorf (November 13-16) once again features an exciting scientific programme.
Basque researchers propose a bioelectronic device consisting of gold electrodes coated with a smart polymer capable of capturing and releasing cells in a non-invasive, controllable way.
Half as thick as a human hair: Researchers at TU Munich have developed the world's first microrobot capable of navigating within groups of cells and stimulating individual cells.
A new nanocomplex renders a tumor harmless – and, on top of that, it trains the immune system to detect and eliminate metastases.
A new type of microdevice could offer new ways to treat brain cancer. The shape and size of a grain of rice, it is implanted into a tumor to study the effects of ongoing therapies.
Cancer has become strikingly more common in people under 50 in the past three decades, an international research team finds. The reseachers explore what this means for future death tolls.
Where are the beginnings of breast cancer? A team of researchers at Kyoto University has revealed the mechanism by which breast cancer is formed in the cells of mammalian epithelium.
For the first time, researchers show that AI-based predictions can deliver comparable results to clinical tests on biopsies of patients with colorectal cancer (CRC).
In thyroid removal surgery, reliable discrimination between different tissues is crucial. US surgeons have evaluated how a new handheld device using mass spectrometry can assist them.
Using data from more than 400,000 individuals, researchers have created a platform for predicting the risk of developing blood cancers such as acute myeloid leukaemia over a 10-15-year period.
Patients with immunodeficiency cannot benefit from conventional Covid-19 vaccines and still at risk from infection. A promising new approach now brings hope for this patient group.
A new analysis exploring the finances of bringing new cancer drugs to market has found that precision oncology drugs could be $1 billion cheaper to develop than non-precision drugs.
Brain tumour progression to a malignant state is believed to be the result of an intricate interplay between cancer cells and the tumour microenvironment. Greek researchers shed new light on the mechanisms.
Scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.
In a new editorial paper, researchers from the Army Hospital Hamburg discuss treatment strategies for common, but highly malignant types of head and neck tumors.
Researchers have unveiled a key mechanism of breast cancer cells to infiltrate lymph nodes. The discovery may lead to new metastasis-blocking treatments and improve patients’ lives.
A tiny robot which can travel deep into the lungs to detect and treat the first signs of cancer has been developed by researchers at the University of Leeds.
A new study by investigators from Brigham and Women’s Hospital demonstrates the potential for restoring fertility when the ovaries have stopped working.
A new study led by researchers from the University of Notre Dame links a high body mass index (BMI) to alterations in the structure and environment of cancerous tumors.
A placenta on a chip developed at the University of Dundee has the potential to transform research into life-threatening conditions in pregnancy.
Researchers have found a possible explanation as to why higher breast density and older age increase the risk of breast cancer. According to the experts, adipocytes play a vital role here.
Scientists have designed an AI tool that can rapidly decode a brain tumor’s DNA to determine its molecular identity during surgery — critical information that can guide treatment decisions.
Plastics are a part of everyday life, and an increasingly concerning factor of global environmental pollution. They also have infiltrated our bodies as microparticles (MPs) and nanoparticles (NPs), found even in placentas supporting foetal life. And they are in our blood. Now, researchers in Spain have developed a new method to detect and measure nanoparticles in human peripheral blood that is…
Researchers from Queen’s University Belfast have created personalised 4D printed “smart” implants for breast cancer management - a first for this technology.
Treatment times for radiotherapy could be reduced for some early breast cancer patients, according to a trial led by University of Cambridge and The Institute of Cancer Research, London.
Research by the University of Southampton has shown that repeated Covid-19 vaccination increases the ability of lymphoma patients to prevent infection from the virus, particularly after four doses.
A new PET tracer, 89Zr-DFO-girentuximab, can accurately detect a type of kidney cancer called clear cell renal cell carcinoma and differentiate it from other types of kidney tumors.
The combination of curettage and cryosurgery is safe and effective for treating the most common form of skin cancer, basal cell carcinoma, a study from the University of Gothenburg shows.
A new US-led study shows that astrocyte brain cells play an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.
For proton radiation therapy against cancer, there is yet no direct method for mapping the beam range during dose delivery. A new method devised by Dresden scientists could help.
Researchers at Harvard Medical School developed a new tool that promises to improve the way pathologists see and evaluate a tumor by providing detailed clues about the cancer.
A mystery which has stumped bowel cancer researchers for decades, has been solved by scientists at the Cancer Research UK Beatson Institute and University of Glasgow.
Folate-based radiopharmaceuticals can be used in positron emission tomography (PET) imaging to detect folate receptors in brain tumours, researchers from the University of Turku report.
Chimeric antigen receptor (CAR) T-cell therapy is an immunotherapy treatment that re-engineers a patient’s own T-cells to help them attack malignant tumour cells. It has been very effective in the treatment of blood cancers, including certain types of leukaemia and lymphoma. However, two serious side effects are common as a result of the treatment: cytokine release syndrome (CRS) and immune…
US researchers identified a potential breakthrough in glioblastoma treatment. Using a modified virus, they created a treatment that specifically attacks tumor cells, while leaving normal cells intact.
French scientists discovered that CD4 T cells generated during immunotherapy are capable of remotely neutralizing tumor cells by producing interferon gamma (IFN-γ).
Unanswered questions are hampering clinicians in their efforts to get the best out of a precision medicine approach for their patients. Speaking at the Genomics and Precision Medicine Expo in London at the end of May, cancer educator Dr Elaine Vickers said the benefits of being matched to an investigational drug remain questionable for most people with advanced cancer.
AI could find critical biomarkers that predict non-response to conventional treatment in patients with chronic myeloid leukaemia (CML) more quickly, researchers in Singapore find.
Gene alterations in biliary tract cancer offer potential targets for current or future precision therapies. This is demonstrated by a new study from Vienna.
New research from the University of Helsinki increases the understanding of ovarian cancer: the identification of new subtypes could help discover new treatments.
Researchers from the Organoid group (Hubrecht Institute) and UMC Utrecht have developed a biobank with organoids derived from patients with head and neck cancer (HNC).
Tumors sometimes seem to take on a life of their own, with cancer genes “striking out” in ring shapes. An international research team has new insights into this phenomenon.
Dutch scientists have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer.
New research has identified a potential therapeutic target and developed a unique delivery system to treat osteosarcoma, a bone cancer that primarily affects children and adolescents.
A group of researchers has illustrated the mechanistic pathway for PTEN-deficient breast cancer and successfully tested a method of countering the downstream effects of immune system evasion by tumors.
Should patients over the age of 70 with head and neck cancer receive aggressive combined radiotherapy and chemotherapy? This is a controversial issue among patients, their families and health professionals.
A new class of immunotherapy shows promising results for fighting the most aggressive form of skin cancer.
For patients with human papilloma virus associated oropharynx cancer, assessing the presence of cancer cells beyond the lymph nodes is critical in determining proper treatment.
Women with triple-negative breast cancer who received multiple antibiotic prescriptions within three years after their cancer diagnosis were more likely to experience disease recurrence and to die from their cancer.
For decades, researchers have marveled at the ability of glioblastoma, a particularly aggressive brain cancer, to turn off a patient's cancer-fighting immune cells, thereby allowing tumors to grow freely.
A new artificial intelligence model could bring much-needed clarity to doctors delivering prognoses and deciding on treatments for patients with colorectal cancer.
Researchers at the University of Campinas and the Federal University of São Carlos in Brazil have developed an electrochemical sensor that detects Parkinson's disease at different stages.
An international coalition of biomedical researchers has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients' risk of blood cancer.
Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the chemotherapy of testicular cancer.
Like the better-known prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) is a biomarker that can tell physicians much about a patient's metastatic prostate cancer.
US researchers have developed a way to use MRI scanning to map body cell metabolism, opening up new possibilities for detecting cancers and revealing if a tumor is responding to treatment.
A UK research team has developed a new technique that combines machine learning with short-wave infrared (SWIR) fluorescence imaging to detect precise boundaries of tumors.
Chemotherapy resistance is a main cause of treatment failure and death in cancer patients. Researchers from Brussels found how cancer cells protect themselves from the aggressive treatment.
A novel imaging modality that can visualize the distribution of medical radiopharmaceuticals with very fine resolution has been developed and successfully tested.
A new real-time imaging technique that uses a type of infrared light has, for the first time, been used during surgery to differentiate between cancerous tumours and healthy tissue.
A team of scientists has successfully generated genetically defined mouse models for two subtypes of multiple myeloma. This will contribute to a better understanding of how the disease develops in humans.
For pancreatic cancer, the effect of immunotherapy is limited and differs between men and women. Researchers at Karolinska Institutet have now found a possible explanation for this sex difference.
Scientists have discovered why breast cancer cells that have spread to the lungs may ‘wake up’ following years of sleep - forming incurable secondary tumours.
Researchers from the US, Singapore and Geneva have developed a novel combination therapy using an anticancer agent for treating vancomycin-resistant Enterococcus faecalis (VRE).
Cancer cells have an innate randomness in their ability to respond to chemotherapy, which is another tool in their arsenal of resisting treatment, new research shows.
Researchers at the University of New South Wales unveil prototype device that can directly 3D print living cells onto internal organs and potentially be used as an all-in-one endoscopic surgical tool.
A new study confirms that haematopoietic stem cell transplantation can be used to cure patients with HIV infections. This third successful case gives new insights into the underlying processes.
Researchers in Frankfurt have now been able to show how ferroptosis can be used to make immunotherapies against liver cancer more effective in mice.
Scientists are developing a new kind of light-activated cancer treatments. This would work by switching on LED lights embedded close to a tumour, which would then activate biotherapeutic drugs.
New research will bring together scientists from across the globe to accelerate fluorescence-guided surgery for bone cancer patients. The upcoming trial is focused on the dye indocyanine green (ICG).
In a promising study, Canadian researchers have shown for the first time in mice that modifying intestinal flora before surgery could reduce postoperative complications in colorectal cancer patients.
A Korean research team successfully changed the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.
A new study from Spain has demonstrated the efficiency of an ultrasound radiation-based therapy on the inhibition of cancer cell motion in pancreas cancer models.
A new approach on the genetic tool CRISPR-Cas9 could reduce the risk of unwanted mutation, making it safer for use in humans, Dutch researchers have found.
Combining single-cell data with a self-learning algorithm reveals how structural changes in chromosomes can trigger cancer. This could pave the way for personalized cancer treatments.
In a new study, researchers from Kanazawa University show how some intestinal cancer cells lose their ability to spread as they divide and can be eliminated as the cancer grows.
Focused ultrasound (FUS) ablation is an emerging treatment for breast tumours. Its use was highlighted in an October webinar focused on emerging immunotherapy research and breast cancer.
Dutch physicians have developed a system to determine the right dose of immunosuppressive drugs for patients to receive a donor liver - to prevent the activation of the Epstein-Barr virus.
Dutch scientists have discovered how specialized immune cells can detect and remove cancers that are ‘invisible’ to the conventional defense mechanisms of the immune system.
Researchers generated human mini bones in the lab which mirror the composition and function of human bone - a step toward the development of future patient-tailored models of bone cancers and tumors.
A novel imaging agent can reduce the number of false-positive PET/CT findings among cancer patients recently vaccinated for Covid-19. This may mitigate the issue of tracer uptake in lymph nodes associaed with the vaccine.
A rare variant of a protein present in nearly all human cells may hold the key to improving the effectiveness of breast cancer treatment, according to University of Manchester research.
Scientists have discovered a way to train healthy immune cells to acquire the skills of some tumor cells for a good purpose: to accelerate diabetic wound healing.
Swedish researchers have developed a method that should be able to predict whether a patient with breast cancer will benefit from a particular treatment or not.
New advanced therapies can alleviate or cure chronic diseases. But medical progress, such as the gene editing tool CRISPR, raises the question of how rights should be protected and balanced.
Researchers at the University of Tokyo have used artificial DNA to target and kill cancer cells in a completely new way. The method showed promising results against various cancers in lab tests on mice.
Scientists managed to identify and kill breast cancer cells that evade standard treatments in a study in mice. The is a step towards the development of new treatments to prevent relapse in patients.
New research shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. This could improve diagnosis and treatment of uterine cancer.
AI-based models for multimodality hybrid imaging have the potential to be a potent clinical tool but are currently held back by a lack of transparency and maturity, says Dr Irène Buvat, from the Laboratory of translational Imaging in Oncology, Institute Curie in Paris, France.
Glioblastomas march to the beat of a different drum: researchers discovered a type of cells that act as pacemakers, driving the growth of the brain tumour and increasing its resistance.
In a recent study, a US research team developed a revolutionary laser-based approach to perform microbiopsies. Their novel method could make biopsies faster, more cost-effective, and less harmful to the patient.
Dutch scientists have performed whole-body PET scans using a radioactively labeled antibody tracer against immune cells, to predict the effect of treatment with immune checkpoint inhibitors.
Scientists from Singapore discovered a novel low-cost method of testing for cancers. The test sequences heated clinical samples to isolate cancer-specific signatures found in a patient’s blood.
Canadian researchers have developed a new method of killing brain cancer cells while preserving the tissue around it. A remarkable side-benefit: chemotherapy of the cancer suddenly becomes possible.
Using fluorodeoxyglucose positron emission tomography (FDG-PET) imaging may give insights into possible dose reductions in ongoing radiation therapy of head and neck cancer. A promising study to explore this option was presented at the 2022 ASTRO/ASCO Multidisciplinary Head and Cancer Symposium held in Phoenix, Arizona.
Breast cryoablation is an emerging treatment for early-stage, localized breast cancer that destroys malignant tumours by freezing them. During the past decade, it has been increasingly utilized as an alternative to lumpectomy, but its long-term benefits compared to other breast cancer treatments are still unproven.
An international team highlights the importance of localising BRCA1 and BRCA2 gene mutations for the treatment of ovarian cancer.
This summer, The European Commission launched I3lung, a new research initiative as a part of Horizon Europe, the EU’s research and innovation program. This research initiative aims to create a cutting-edge, decision-making tool to help clinicians and patients select the best lung cancer treatment based on each patient’s specific needs and circumstances.
New research has found variable voltages in the membranes of breast cancer cells, revealing clues about how they grow and spread.
It is the size of a common pencil eraser, but it could have a huge impact on the therapy of glioblastoma: Scientists in Virginia have developed a novel 3D tissue-engineered model of the brain tumour microenvironment, which can be used to assess how the glioma cell invades healthy tissue, proliferates, and reacts to chemotherapy drugs.
Researchers in Barcelona discovered the population of residual tumour cells responsible for the recurrence of colorectal cancer in other organs after removal of the primary tumour.
Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease.
Until now, it was feared that vaccination against Covid-19 could reduce the success of treatment for patients with nasopharyngeal cancer. A recent study now gives the all-clear in this regard.
A new randomized study confirms that men with high-risk prostate cancer can be treated with a moderately shortened course (5 vs. 8 weeks) of radiation therapy.
Researchers from Barcelona report that vaccination with senescent cells shows promise in experimental models of melanoma and pancreatic cancer.
Bowel cancer patients could in future benefit from a new 3D bioprinting technology which would use their own cells to replicate the complex cellular environment of solid tumours in 3D models.
The risk of developing breast cancer is higher in breasts with high density. But why is that? Researchers at Linköping University have shown major biological differences that promote cancer growth.
99mTc-Sestamibi SPECT/CT can aid in the diagnosis of solid renal lesions, especially in cases where contrast enhanced CT findings are inconclusive, according to researchers from the Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis, Missouri.
With the rise of syndrome-style infections, co-infections and the current antimicrobial resistance challenges, the need for multiplexed diagnostics is now more important than ever.
Focal treatment of prostate cancer involves treating only the tumor and not the entire gland, sparing surrounding tissue and nerves. The method is being evaluated in a research study.
Colorectal cancer is one of the most common cancers. A team from the University of Geneva has found an alternative for patients who have developed resistance to chemotherapy treatments.
Some leukemias evade treatment by changing their appearance and identity through changing the read-out of their DNA, a new study has found.
Researchers in Finland have identified that finger-like cellular extensions called filopodia contribute to building a barrier surrounding breast tumours.
Scientists have discovered that cervical cancer can be divided into 2 distinct molecular subgroups – one far more aggressive than the other – as part of the largest ‘omics’ study of its kind.
A simple 'liquid biopsy' blood test could help guide the treatment of children with the cancer rhabdomyosarcoma, a new study reports.
The tall cell variant (TCV) is an aggressive subtype of papillary thyroid carcinoma (PTC). Sebastian Stenman, researcher from the Institute for Molecular Medicine, and the Department of Pathology at the University of Helsinki, Finland, is developing and training a deep learning algorithm using supervised learning to detect and quantify the proportion of tall cells in PTC.
What if a test analysing cervical cells from a gynaecological swab could be used to detect four different female cancers at an early stage and also predict cancer risk over a healthy woman's lifetime? Researchers at the EUTOPS Institute in Innsbruck, Austria, are developing tests to do just that for breast, ovarian, cervical, and endometrial cancer detection.
Deaths from cancer are currently estimated at 10 million each year worldwide. Conventional cancer staging systems aim to categorize patients into different groups with distinct outcomes. ‘However, even within a specific stage, there is often substantial variation in patient outcomes,’ Markus Plass, academic researcher from the Medical University of Graz, Austria, explained to Healthcare in…
Renal cell carcinoma is among the fifteen most common cancers worldwide. Dr Titus Brinker, from the German Cancer Research Center (DKFZ), looked at whether a convolutional neural network (CNN) can extract relevant image features from a typical H&E-stained slide to predict 5-year overall survival.
Researchers propose a new approach to identify cancerous tissue for surgical removal, based on real-time imaging of tissue oxygen concentration.
Researchers in Munich have developed a novel model system that can be used to precisely track the growth steps and three-dimensional arrangement of pancreatic cancer cells.
Scientists in Italy discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells. They also devised an experimental therapy to bypass or prevent this.
Cambridge scientists have discovered that cancer cells ‘hijack’ a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.
A newly developed capsule that tunnels through mucus in the GI tract could be used to orally administer large protein drugs such as insulin.