As TIL therapy remains difficult to access across Germany and Austria, Sheba offers more than 15 years of experience, in-house cell manufacturing, and one of the world's leading cellular therapy programs for advanced melanoma.
A new study has identified a way to reshape the gut microbiome that can enhance the delivery of certain chemotherapies to tumors, making these nanoparticle-based cancer drugs more effective.
As access to TIL therapy remains limited across Europe, Sheba Medical Center combines 15+ years of experience, in-house manufacturing, and pioneering research to advance melanoma and CAR-T therapies.
The members of the American Society for Radiation Oncology (ASTRO) recently elected five new officers to its Board of Directors. Beth Erickson, MD, FASTRO, has been elected President of the medical society.
Chemotherapy of many childhood cancers leaves specific traces in the DNA, a new study finds. These changes could help clinicians spot treatment resistance earlier, before cancer returns or spreads.
Low brain metabolism as measured from 18F-FDG PET/CT is associated with higher mortality in patients with advanced non–small cell lung cancer (NSCLC), according to new research.
Tumour-infiltrating lymphocytes are key players in cancer immunotherapy. New research explores the role of location in the tumour microenvironment – knowledge that could help improve treatments.
Photothermal therapy to selectively destroy cancer cells shows promise as a much less invasive treatment option than surgery or radiation. Now, researchers cleared two major hurdles for the method.
A swallowable "nanocage" may offer a new strategy for treating gastric cancer more precisely while reducing damage to healthy tissue, according to findings from a new preclinical study.
A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, new research reveals. The findings could open the door to new ways to prevent cancer metastasis.
Researchers have developed a method to enhance the cellular features in pathology slides based on “structural color” – the same effect that gives peacock feathers their unique sheen.
Detecting genetic mutations associated with lung cancer via laboratory tests can be expensive and time-consuming, and use up valuable tissue from small biopsy samples. A new approach aims to fix this.
A blood test for ctDNA may help identify which patients with colorectal cancer that has spread to the liver are most likely to benefit from chemotherapy after surgery, according to new research.
Why do some prostate cancers grow slowly and remain localized while others become aggressive and metastasize? In a new paper, researchers identify the answer: tumor methylation.
Researchers have developed a new lab model to study BAP1-deficient melanomas, a rare type of melanoma that evade the immune system once they metastasize and are resistant to current immunotherapies.
Tiny algae-based robots guided by magnets could improve bladder cancer treatment by boosting delivery of chemotherapy drugs into tumours, results from a new study suggest.
A study from the University of Calgary shows that removing a single gene makes colon cancer cells a target for immunotherapy — a fundamental breakthrough.
A Taiwanese research team found that BET inhibitors can restore exhausted T cells by reprogramming their metabolism – a potential new strategy for cancer immunotherapy.
AI is transforming the way cancer is diagnosed and treated. Dr Yuri Tolkach shared his group's advances in developing AI-based tools for oncological pathology at the DPAI Europe congress.
Prof. Johanna Joyce has begun her two-year term as President of the European Association for Cancer Research (EACR), a global community of scientists and clinicians dedicated to advancing the scientific understanding of cancer and its application to improve patient care.
Many people with breast cancer can avoid chemotherapy with a gene test, potentially sparing them side effects without increasing the risk of the cancer returning, a clinical trial has found.
A new type of peptide receptor radionuclide therapy (PRRT) appears to be safe in metastatic neuroendocrine tumor patients who have exhausted conventional treatment options.
Obesity may change how early-stage breast cancer becomes invasive, according to a new study. The findings could help improve physicians’ ability to predict and treat the disease.
A new AI model enables more efficient analysis of tissue samples taken from colorectal cancer tumours. This can help shorten diagnosis times, reduce costs, and improve diagnostic accuracy.
A simple, affordable urine test could detect early signs of lung cancer months, or even years, before symptoms appear, as well as monitor whether treatment is working and identify potential relapse.
Pancreas lesions are of diagnostic concern, as they may evolve into pancreatic cancer – but many never do. New research findings help explain how the transformation into a malignant state works.
Once breast cancer begins to metastasise, it generally becomes harder to treat and survival rates are lower. Now, researchers present a new, targeted treatment approach using SBRT radiotherapy.
Researchers have reported results from a first-in-human trial evaluating a novel cell-based platform for localized delivery of interleukin-2 (IL-2) in patients with advanced ovarian cancer.
A new ultrasonic needle for tumour diagnostics could be used to diagnose salivary gland tumours with far greater precision, a new study finds. The device also shows potential for other cancers.
New research reveals that testosterone slows glioblastoma growth—the opposite of the androgen’s effect on tumors outside the brain.
A CRISPR-based tool called Cas12a2 can selectively eliminate cancer and virus-infected cells based on their RNA signature – with high precision and no off-target effects.
Researchers are developing nanozymes to improve treatment of aggressive brain tumours. The tiny particles can be activated by near-infrared light and applied directly during surgery.
Researchers have used cryo-expansion microscopy to capture cytotoxic T lymphocytes destroying cancer cells in unprecedented 3D detail, opening new paths in immuno-oncology.
A new analytical method could improve how cancer treatments are designed – by allowing scientists to track, for the first time, exactly where inside a living cell a drug accumulates.
Not all precancerous lesions will develop into tumours, yet the majority are treated as if they were already breast cancer. A new marker could help identify the relevant cases and avoid overtreatment.
A new technique to “prime” a patient's immune system before liver transplantation has proven itself in a first-in-human clinical trial to successfully prevent transplant rejection.
Why does the same genetic mutation cause FCDII in some patients but not in others? Researchers developed organoids to model a brain malformation responsible for drug-resistant epilepsy in children.
Researchers have taken an early but promising step toward a cancer therapy that targets and destroys tumor cells with high precision, using a variant of the DNA editing tool CRISPR.
A multidisciplinary team of pathologists, oncologists and biologists has discovered a new biomarker to determine whether immunotherapy may work in people with colon and rectal cancer.
Patient-derived organoids (PDOs), or tumoroids, for pediatric brain cancer show promise in helping researchers find new drugs and better understand the different responses of the tumor.
A new scientific study reveals a strong link between exposure to agricultural pesticides in the environment and the risk of developing cancer on a national scale.
As women age, their breast tissue goes through major changes, with the most dramatic changes at menopause, but also during pregnancy and childbirth. A map reveals the impact on breast cancer.
A new review shows that chronic stress may actively drive cancer progression. Therefore, psycho-oncology should be part of standard cancer care, the researchers argue.
The chances of breast cancer recurring remain very low when patients are treated with radiotherapy that is tailored to their individual risk following chemotherapy and surgery, new study results find.
A new X-ray imaging technique could transform how hospitals analyse tissue samples, potentially speeding up diagnoses and improving outcomes for patients, a new study shows.
Two new studies explore the role of the thymus – a small organ in the chest, and possibly a missing piece in explaining why people age differently, and why cancer treatments fail in some patients.
Why do some cancer cells develop treatment resistance? The answer may lie in hidden “storage hubs” inside tumour cells, which create uneven drug exposure across tumours, according to new research.
A PSMA PET/CT imaging test could safely halve the number of people who need a biopsy for suspected prostate cancer following inconclusive or reassuring results from an MRI scan, new research finds.
A hidden immune circuit in the uterus revealed: Researchers have discovered a crucial immune switch that sheds light on preeclampsia and early pregnancy failure.
Researchers discovered that pineoblastoma, retinoblastoma and medulloblastoma – severe brain tumours in children that appear to be completely different – actually arise from the same type of cell.
About 50% of triple-negative breast cancer (TNBC) patients develop resistance to therapy, significantly reducing the chances of survival. Researchers found there is more than one way this can happen.
A small but growing body of evidence suggests that a minimally invasive surgical procedure called lymphovenous anastomosis (LVA) might be an effective treatment for Alzheimer's disease.
A research team led by the University of Waterloo is developing a novel tool to treat cancer by engineering hungry bacteria to literally eat tumours from the inside out.
Although tumours may at first shrink under therapy, they often regrow or even become resistant. A new study suggests switching to a second treatment while the tumour is still responding to the first.
Clues in the CSF: Researchers have developed the first high-precision method that can theoretically diagnose common brain tumors in children and adolescents without surgery.
Radiotherapy is more effective when administered at the right time of day, according to new research. This discovery opens the door to cancer “chronotherapy”, the researchers hope.
Due to its rapid spread in the abdomen, ovarian cancer is often only detected at an advanced stage. Now, scientists have discovered how this cancer takes advantage of other cells for metastasis.
Not all cancer mutations are equal: new research shows that a single mutation hotspot can generate a rich diversity of tumour behaviours. This could lead to more personalised cancer treatments.
Reseachers show how Candida albicans – a fungus living in our body – can make melanoma more aggressive. The results pave the way for antifungal therapies to complement skin cancer treatments.
Beyond "one-size-fits-all": A new strategy that combines two types of PET scans can guide personalized radiotherapy for head and neck cancers, according to new research.
Scientists have shown that a type of laser similar to the one currently used in routine eye surgery could one day help surgeons remove unwanted tissues, such as tumours, with unprecedented accuracy.
Why do some tumours spread while others remain localised? Using colon cancer cells, scientists pinpointed the criteria that influence metastasis risk, and identified a way to assess its probability.
A new type of lab-grown organoid that mimics the behaviour of a human stomach could boost the understanding of rare gastric diseases, researchers say.
Chemotherapy does more than kill cancer cells: It reshapes the gut microbiome, making the body less permissive to metastasis. This finding opens new avenues for adjuvant strategies.
The Kraft Center for Community Health has launched a new prize to recognise organisations using technology to transform healthcare access for underserved populations. At the 2025 World Medical Innovation Forum in Boston, ThriveLink – an AI-powered telephonic enrolment platform – was announced as the inaugural winner, receiving US $100,000 to further its mission of connecting families to vital…
Should younger and older people receive different treatments for the same infection? New research suggests that age-specific treatments may be necessary in ongoing antibiotic resistance crisis.
DNA analysis of colorectal polyps provides important additional information on the development of these polyps and colorectal cancer, research finds. This leads to better diagnostics and treatment.
Immunotherapy has been hailed as a breakthrough in cancer treatment. But new research reveals: under sustained treatment pressure, cancer does not simply weaken — it adapts, learns, and fights back.
A new study shows a significant survival benefit for patients with oropharyngeal cancers treated with proton therapy (IMPT) compared to those treated with traditional radiation therapy (IMRT).
Gene-editing technologies show great promise for medical treatments and research, with the potential to cure thousands of genetic diseases. At the 2025 World Medical Innovation Forum in Boston, leading experts explored the possibilities and challenges of these rapidly advancing tools. The case of Baby KJ Muldoon – an infant treated with a personalised CRISPR therapy developed in just seven…
Researchers have developed a prototype injectable paste that could help restore breast volume after tumor removal, with less scarring and shorter healing time than current options.
A sample of inequality: A new study shows that AI models can infer demographic information from pathology slides, leading to bias in cancer diagnosis among different populations.
To soften up tumors prior to cancer chemotherapy, a team of researchers paired high-frequency ultrasound waves with a type of sound-responsive particle to reduce the protein content of the tumors.
After T-cell redirecting therapies, patients are typically hospitalized for several days to watch for side effects. New research shows that these patients can safely be monitored at home.
While saving lives remains the primary goal, a new study explores how radiation therapy also helps breast cancer survivors return to work. Policymakers should factor this in, the researchers argue.
Delivering a pathology service in resource-constrained locations and developing countries remains a challenge. Cost is a significant barrier, as is the availability of equipment, trained staff and technical and IT support can also hinder a desire from clinicians and pathologists to give their patients a high level of service to help their diagnosis and recovery. The subject was tackled in a…
A major new initiative aims to enable the development of advanced, specific and highly reproducible human in vitro models for greater understanding of disease and the acceleration of new medicines.
New hope for patients with neurological diseases: A combination of focused ultrasound and gene therapy enables targeted, nonsurgical control of seizure-relevant brain regions.
An international research team has discovered a promising new therapeutic approach for aggressive prostate cancer – in the thyroid gland.
Just like the “ABCDE” mnemonic for melanoma awareness, researchers hope their diagnostic tool will transform how doctors approach persistent rashes, reminding them to consider lymphoma sooner.
Using a bioengineered bone marrow model, researchers were able to provide key new information on the efficacy and safety of CAR T-cell therapy for acute myeloid leukaemia (AML), the most common leukaemia in adults.
Most patients with metastatic colorectal cancer do not respond to immunotherapy—but why? A new study shows how the tumours block the immune system through two complementary mechanisms.
Researchers explore how ultrasound waves can be used to activate chemotherapy drugs only in targeted areas, offering a new path toward safer, more effective cancer treatment.
Hengrui, one of China's leading pharmaceutical companies, is preparing to bring its cancer therapies to international markets. At the ESMO congress in Berlin, Yuting (Shelley) Liu, Head of China Business Development and Strategy of Hengrui Pharma, shared insights into how the company is translating decades of Chinese market experience into a global oncology strategy.
Biomarker testing is ushering in a novel era of therapy personalisation for gastroesophageal and colorectal cancers, according to experts presenting at the 37th European Congress of Pathology in Vienna this September. During a session on state-of-the-art in gastrointestinal biomarkers, speakers outlined how targeted therapies and immunotherapies are transforming treatment options – but…
Researchers have discovered a previously unknown mechanism that explains how bacteria within a tumor can drive treatment resistance in patients with oral and colorectal cancer.
A novel imaging solution, called PSMA PET scanning, can more effectively detect the recurrence of prostate cancer compared to standard methods, and is associated with improved survival outcomes.
Scientists are on the way to finding a vaccine to fight off Helicobacter pylori - a bacterium found in over 60% of people - possibly preventing stomach ulcers and lowering the risk for stomach cancer.
Chronic fatigue (ME/CFS) affects millions worldwide, but is poorly understood and has long lacked reliable diagnostic tools. Now, a new blood test claims to diagnose the condition with 96% accuracy.
Breast cancer claims around 670.000 lives each year. Now, researchers propose that whole genome sequencing (WGS) could help many patients find better treatments or match them with clinical trials.
The 2025 Nobel Prize in Physiology or Medicine is awarded to three researchers for their insights into peripheral immune tolerance - how our immune system is kept from attacking our own body.
Immunotherapy has improved the treatment for many cancers, but progress has been limited in leukemia. Discovery of a new evasive mechanism could help change that.
Using PET/CT imaging, researchers discovered that the biological activity of visceral fat may drive the progression of endometrial cancer, offering a novel angle for diagnosis and treatment.
Scientists have shown for the first time that glioblastoma—the deadliest form of brain cancer—affects not just the brain but also erodes the skull, alters the makeup of skull marrow, and interferes with the body’s immune response.
Researchers from the University of Birmingham’s Bladder Cancer Research Centre have found a new way of detecting tumour DNA in urine to identify bladder cancer.
TU München researchers discover how chronic cellular stress changes gut microbiome composition, promoting cancer development through altered lipid metabolism.
Study of 3.7 million children reveals small but significant increased risk of blood cancers from medical imaging radiation, with CT scans posing highest risk
University of Stuttgart scientists develop enhanced CRISPR technique that makes genetic loss-of-function analyses more efficient and reproducible for medical research.
A new technique has measured boron in individual cancer cells for the first time, enabling researchers to better understand how drugs act to kill tumours in some cancers.
In metastatic EGFR-mutated non-small cell lung cancer (NSCLC), targeting residual disease through surgery can extend the benefits of EGFR TKI therapy beyond standard monotherapy, a new study finds.
Researchers explored two promising new biomarkers as potential radiotheranostic targets for endometrial cancer. This could help identify patients who are likely to respond to targeted therapeutics.
A new study shows that a gene expression test on routinely collected prostate tissue can help guide therapy choices for prostate cancer patients whose cancer has spread to other parts of the body.
A newly developed method to accurately quantify how much radiation is absorbed by the blood during cancer treatment could lead to more personalised, preventive, and safer radiotherapy.
Scientists developed an AI-based approach to diagnose colorectal cancer from different microbial subgroups in the gut microbiota – a non-invasive and low-cost alternative to colonoscopy screening.
Studies have found that natural polysaccharides from a medical fungus endemic to Taiwan can not only effectively inhibit inflammation, but also fight the proliferation of lung cancer cells.
Tracer molecules serve to provide visual guidance in nuclear medicine, but a new molecule could give surgeons additional audio cues to help them locate prostate cancer tumors and metastases.
An artificial heart valve made from SEBS, a new type of highly durable and biocompatible plastic, could be a step closer to use in humans, following a successful long-term safety test in animals.
Researchers report they have built a new non-toxic and non-radioactive handheld device that uses the unique properties of diamonds to diagnose metastasized breast cancer.
Microsatellite instability-high (MSI-H) tumors are associated with better clinical outcomes. A novel AI model for accurate MSI prediction could help battle gastric and colorectal cancers.
Some medications can only be taken as an injection, which is often painful, unpleasant and inconvenient for patients. A new transport system could make it possible to swap these injections for pills.
Tumor vesicles may serve as early indicators of cancer and help monitor the effectiveness of treatments. Now, researchers discovered a new way to detect these vesicles.
Defining four different immunologic subtypes of recurrent ovarian cancers, researchers pave the way for more personalized treatment.
Classifying prostate cancer as “low-grade” could create a false sense of security and delay definitive treatments. A new study shows that the biopsy grade alone can paint an incomplete picture.
Common respiratory infections such as influenza and Covid-19 can awaken dormant breast cancer cells that have spread to the lungs, setting the stage for new metastatic tumors, new research finds.
How cancer cells survive the journey through the body to form metastases is still poorly understood. New insights into how cells survive intense physical stress could pave the way for new treatments.
Melanoma testing could one day be done at home with a skin patch and test strip with two lines, similar to Covid-19 home tests, according to University of Michigan researchers.
By analyzing CT images with 3D software, researchers demonstrated that small liver tumors can be successfully treated using ablation. This could enable more confident use of ablation treatments.
A new, bacteria-based contrast agent illuminates tumors like a neon sign during surgery, enabling more precise resection and reducing the risk of recurrence.
Dense calcifications are common in breast tissue, but not every finding in a mammogram is a precursor of cancer. New insights could lead to fewer benign biopsies and guide therapeutic development.
Through quantitative real-time monitoring of cell spatiotemporal dynamics, or cell changes over time, electrical impedance spectroscopy (EIS) could be used to predict cancer growth.
A new AI-based tool measures cancer aggressiveness by analyzing the ‘stemness’ of tumors – their similarity to pluripotent stem cells. This could pave the way for new therapies.
At Medical Taiwan 2025, manufacturers attracted attendees with a wide range of innovations. We took a closer look at some of the most exciting companies and their products on display at the medical, health and care expo.
Medical Taiwan has long been a showcase for cutting-edge healthcare solutions, but this year marked a pivotal moment. Visitors of the latest edition of the medical, health and care expo in Taipei witnessed a particularly noticeable step forward: the definitive transition of medical AI from promising research to actual clinical practice. Organized by the Taiwan External Trade Development Council…
More consistent TIL assessments, more accurate patients' prognoses: New research shows how AI sharpens pathologists' interpretation of tissue samples for malignant melanoma.
A new technique called photoacoustic computed tomography (PACT) offers a breast imaging alternative without the discomfort, high costs, or risk associated with the conventional evaluation methods.
Molecular profiling of over 1,000 nasopharyngeal cancer (NPC) tumours reveals distinct differences in tumour microenvironment of locoregionally advanced NPC, supporting personalised treatment.
A research team at the University of Geneva has identified two new proteins that regulate gene expression, a discovery that could pave the way for new cancer and brain disorder treatments.
New research makes a strong case for a new dual-targeting radiopharmaceutical, designed to attach to two vulnerable sites on cancer cells, enabling more precise and potent therapy.
Newly developed technology can detect breast cancer relapses up to five years in advance. This advance could represent a turning point in post-treatment follow-up, the researchers hope.
In a new study, researchers have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells, to uncover a new therapeutic possibility for limiting breast cancer spread.
A new ‘liquid biopsy’ test can help fast-track lung cancer patients to receive targeted therapy up to two weeks earlier, while helping avoid further tests and treatments including chemotherapy.
Using nine different molecular biological technologies, researchers were able to precisely measure the properties of a melanoma tumor in four weeks and enable a precise treatment decision.
Tongue squamous cell carcinoma, the most common type of oral cancer, is a challenging target for immunotherapies. Researchers now identified five immunotypes to better predict treatment response.
A major challenge in cancer genomics is separating meaningful mutations from false positives. A new tool uses machine learning to significantly reduce these errors.
Childhood cancer diagnosis times span from immediate to delays of several years, according to a new study. Young bone tumor patients are among the most affected by these delays.
A US research team has shown that Sars-CoV-2 can “reprogram” pathogen-fighting white blood cells into immune system suppressing cells — a potential mechanism by which severe Covid may arise.
With the introduction of boron neutron capture therapy (BNCT), Helsinki University Hospital offers a new radiation therapy method that can destroy cancer cells while sparing the surrounding tissue.
Does having blood type A increase the risk of breast cancer? A new systematic review and meta-analysis involving more than 13,000 breast cancer patients suggests a connection.
Results of a new retrospective study demonstrate the potential of a novel, CT-based deep learning-driven tool to enhance liver cancer diagnosis, treatment planning, and response evaluation.
At the San Antonio Breast Cancer Symposium (SABCS), three experts presented new approaches and study results for the treatment of breast cancer in young women.
Using AI and extensive analyses of gene activity in tumours, researchers have found new, precise biomarkers to diagnose prostate cancer at an early stage through a simple urine sample.
A new approach enables the detection of even trace amounts of cancer cells. The method leverages SERS for signal amplification, eliminating the need for fluorescent dyes.
The incidence of colorectal cancer in young adults has doubled over the last 20 years, with no known reason. Now, a new study links this mysterious trend to childhood exposure to a bacterial toxin.
Molecular testing provides a more convenient, personalized way of monitoring of heart transplant recipients, according to insights shared at the Annual Meeting and Scientific Sessions of the ISHLT.
Using an advanced PET scanner, US radiologists explore how cancer, neurodegenerative diseases and other systemic conditions, can affect the brain by assessing the impact on the blood-brain barrier.
Dutch researchers have developed an AI tool to support Mohs surgery, a precise but time-consuming procedure to treat the most common form of cancer in the Netherlands: basal cell carcinoma.
Unprecedented insights into the inner workings of an early-stage lung tumor: An international research team describes a new method for 3D mapping cellular interactions in the tumor microenvironment.
A newly discovered type of cells counteract tumor development and may therefore be a target for research into new treatments for pancreatic cancer, which is one of the deadliest forms of cancer.
Radiation therapy is an effective component of many cancer treatments, but some patients experience severe side effects. A new study shows that hyperbaric oxygen therapy can provide long-term relief.
Breast MRI has emerged as a powerful diagnostic tool, particularly for women with dense breast tissue where traditional mammography faces limitations. In her presentation at ECR 2025, radiographer Hanna Kalliomäki highlighted several technological advances transforming breast cancer detection and diagnosis. From time-saving abbreviated protocols and AI-assisted analysis to contrast-free…
Pancreatic cancer is one of the most aggressive cancers, partly due to its tumor microenvironment, known as the stroma. Now, a study has identified a new key factor contributing to this feature.
Nuclear medicine (NM), one of the more mature technologies of diagnostic imaging, has been experiencing a rebirth in innovation and interest. The increasing prevalence of cancer,, an aging global population, and greater longevity, has created a robust demand for nuclear medicine. At ECR in Vienna, presenters explored market perspectives, but also safety and sustainability challenges.
Researchers developed biomimetic materials inspired by lymph nodes, which could improve cancer immunotherapy. The study highlights the potential of bioengineered scaffolds for cell-based therapies.
New research reveals a method that uses pulsed infrared light to identify molecular profiles in blood plasma that could indicate the presence of certain common cancers.
Fighting pancreatic cancer can feel like a race against time. A new discovery could give clinicians a head start - by targeting precancerous lesions before they become much more aggressive.
A new method to quickly and accurately analyze the structure of collagen in tissue shows promise to improve the diagnostics of cancer and other diseases.
Researchers discovered a key mechanism by which melanomas and other aggressive tumours prevent the immune system from detecting and attacking them – one of the greatest challenges in oncology today.
The location and timing of breast cancer recurrence may allow AI to predict the risk of metastasis, a new study shows. This is an essential step towards developing personalised treatment strategies.
Nuclear medicine specialists have successfully used the radiopharmaceutical Ga-68-Trivehexin from Trimt to accurately diagnose patients with pulmonary fibrosis and concurrent lung cancer.
Cryoablation, the destruction of malignant cancer cells by freezing them, is increasingly becoming an alternative to having conventional lumpectomy for patients diagnosed with early-stage, localised, low-risk breast cancer. Findings from numerous recent clinical trials show that cancer recurrence rates are very low and are comparable to breast conservation surgery (BCS).
New research reveals that self-generated electrical activity of small cell lung cancer (SCLC) directly promotes tumor metastasis and progression. This may provide new avenues for future treatments.
For patients, a liquid biopsy which checks for circulating tumour DNA of colon cancer, resembles a standard blood test. However, the method helps avoid chemotherapy for many, a new study finds.
Japanese researchers have developed magnetic nanoparticles that can be directed to tumors using a magnet and then heated with a laser to destroy cancer cells while sparing healthy tissue.
New research uncovers the hidden diversity of adrenal gland tumors, shedding light on how they cause unusual medical symptoms and paving the way for new drug treatments.
A new AI-enhanced technique makes breast cancer tissue “glow” on MRI scans. This not only improves breast cancer detection but also can help treat it more effectively, the researchers say.
Research on biliary tract cancer is advancing rapidly, ranging from targeted treatments to new drugs. However, the delivery of these advances to patients is lagging behind, new European studies find.
New research highlights the potential of circulating tumor DNA (ctDNA) analysis as a non-invasive method to identify actionable biomarkers for breast cancer, enabling individualized therapies.
The gastrointestinal microbiome holds valuable information that can help predict whether immunotherapy will be successful against melanoma. A new “gut-on-a-chip” is designed to do exactly that.
Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting the aggressiveness of meningioma brain tumors and breast cancers.
Researchers have created a landmark atlas of how healthy breast tissue ages, revealing key cellular, molecular, and genetic changes that may tip the balance toward breast cancer development.
When multiple myeloma cancer cells break out and multiply outside the bone marrow, a wide variety of tumor cells arise, accompanied by a significantly altered immune response, new research shows.
Researchers have developed a new kind of tumour-on-a-chip, which gives insight into the tumour environment and immunotherapy response. The device has been successfully tested on breast cancer samples.
Certain gene alterations can serve as a prognostic and predictive biomarker for prostate cancer. Now, researchers confirm the feasibility of using NGS on this marker for precise patient stratification and treatment selection.
Persister cells arise as a result of cancer treatment and are often responsible for tumour relapse. Researchers identified a distinctive feature of persister cells, paving the way for new treatments.
“What is a tumour?” Researchers explore tumour architecture as a valuable source of information to understand tumour dynamics and predict its sensitivity to anticancer drugs.
Infection with the human papillomavirus (HPV) is the most common cause for cervical cancers. Now, researchers have developed a promising therapeutic vaccine against precancerous lesions.
Senescent cells, which may appear after chemotherapy or radiotherapy, can jeopardize patients' recovery. A study describes a new mechanism to eliminate these cells in cancer patients.
The immune system of children reacts differently to cancer than that of adults. New insights into these differences have the potential to lead to new tailored treatments for children with cancer.
The installation of a state-of-the-art digital PET/CT scanner in Essen marks the German debut for the technology of United Imaging. The device is designed to deliver precision diagnostics at the Kliniken Essen-Mitte Evang and the private nuclear medicine clinic Nukmed, a premier cancer care institution.
Researchers have developed an artificial intelligence (AI) model to detect the spread of metastatic brain cancer using MRI scans, offering insights into patients’ cancer without aggressive surgery.
Steam eliminates wrinkles and germs, but can it destroy cancer cells too? A multisite clinical trial explores the potential of a water vapor system using steam to kill prostate cancer cells.
A new study measured how well breast cancer patients’ tumour ‘explants’ respond to chemotherapy or HER2 antibody therapy in the laboratory. This could help improve clinical outcomes.
By analysing the largest collection of whole-genome data from osteosarcoma patients, researchers identified a driving mechanism behind the aggressive development of these bone cancer tumours.
A new personalised oncology platform has been tested to detect circulating tumour DNA (ctDNA) in patients with lung adenocarcinoma before surgery, to predict their risk of cancer relapse.
Light can change biological processes and affect health. For example, new research finds that red light can lower rates of blood clots that can cause heart attacks, lung damage and strokes.
Why does radiation therapy kill cancer cells from the same tumour in different ways? This has long remained poorly understood. Now, new findings open up opportunities to improve treatment.
Tongue cancer cells can become resistant to chemotherapy under certain circumstances. Investigating these mechanisms, researchers shed light on promising avenues toward new treatments for this cancer.
A premiere that brings hope for fertility restoration to men who underwent chemotherapy during childhood: Researchers reintroduced cryopreserved immature testicular tissue taken 16 years prior.
Researchers have developed an AI-based model to better predict whether cancer patients will benefit from immunotherapy — using only routine blood tests and clinical data.
Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of breast cancer chemotherapy while reducing its harmful side effects.
A molecule called MR1 (MHC Class I-related Molecule 1) enables a newly-discovered type of T-cells to sense differences in the metabolism that occur when cells become cancerous.
Infections with Salmonella can increase the risk of colon cancer. New research sheds light on how this bacterium can cause this. The findings provide new leads for new treatments.
More than half of cancer patients in whom the cancer spreads beyond the primary site have lung metastases. What makes the lungs such a tempting place for cancer cells? New research may have an answer.
Complex diseases could require complex biomarkers for accurate diagnosis in the years ahead, according to a leading pathologist. In a keynote address to the 36th European Congress of Pathology in Florence, Italy, Professor Manuel Salto-Tellez highlighted this as one of the major future challenges for the discipline. However, he also believes pathologists will sit at the core of modern medicine.
Women with breast implants should regularly attend follow-up care to avoid the risk of "silent" implant ruptures and their long-term complications, experts caution in a new publication.
Researchers now succeeded in making leukemia-specific immune cells less sensitive to the influence of tumor cells, thereby significantly increasing their effectiveness.
A new radiotracer – an injected compound used in PET scans – could help inform doctors that a patients aggressive cancer will not respond to chemotherapy before treatment is given.
In a new study, researchers have shown, for the first time, that a particular form of MRI, called diffusion tensor imaging, is capable of robustly detecting pre-malignant lesions in the pancreas.
A new type of photocurrent-responsive coating has been shown to shorten the bone-to-implant integration time after orthopaedic surgery to just two weeks.
Tumors in female fruit flies grow significantly larger than in male ones, a new study finds. The findings could lead to a better understanding of how the biological sex impacts cancer development.
Treating patients with Hodgkin lymphoma with a different form of chemotherapy shows promise to reduce severe side effects, shorten hospital time and increase likelihood of recovering fertility.
Research offers new insights into harnessing the immune system to combat ovarian cancer. The findings could lead to personalized therapies that target the right patients at the right time.
When women are pregnant and nurse their babies, their bodies change to ensure the health of both mother and child. Researchers now surprisingly find that the intestine also changes completely.
A new way to inhibit the proliferation of Sars-CoV-2 opens up new perspectives in the fight against this coronavirus and other viral diseases that still have no medical treatment.
A new MRI-based imaging technique predicts the response of ovarian cancer tumours to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.
In the world of theatre, the ‘deus ex machina’, the god from the machine, is a dramaturgical trick to resolve seemingly unsolvable conflicts. Can artificial intelligence (AI) also be such a universal problem solver for internal medicine? At the Annual Congress of the German Society of Internal Medicine (DGIM), Dr Isabella Wiest explored the potential – and limitations – of AI helpers.
New research has linked having a cerebral stroke to lasting changes in the arteries in the abdomen. The study in animal models with hypertension could lead to new preventative strategies.
US researchers have developed a comprehensive deep learning AI model designed to more accurately identify and classify cells in high-content tissue images.
A research team has found wearable organic x-ray sensors could be the answer towards safer radiotherapy protocols for cancer patients, reducing the debilitating side-effects of the treatment.
A new study shows how inherent variations in a cancer cell and its interactions with its surroundings mould its migration. The findings provide valuable insights into the processes behind metastasis.
New insights into the previously unknown diversity of cancer-associated fibroblasts in basal cell carcinoma, squamous cell carcinoma and melanoma could pave the way for new therapies.
A certain type of cells, called aneuploid epithelial cells, are usually associated with breast cancer. However, new research reveals that they can also be found in healthy women.
A new approach to fight glioblastoma: Swiss researchers have now developed an immunotherapy that not only attacks the brain tumor—it also turns its microenvironment against it.
PET/CT image analysis using artificial intelligence (AI) can predict the occurrence of interstitial lung disease, a serious side effect of immunotherapy in lung cancer, a new study shows.
New research highlights the potential of liquid biopsy in diagnosing pancreatic incidentaloma - lesions which can occasionally signal pancreatic cancer in its earliest stages.
Molecular pathology should become centralised in fewer labs to improve efficiencies and affordability, according to leading European experts.
Skills shortages and digitalization, trends in cardiology and oncology, future prospects in laboratory medicine, and healthy aging – these pressing topics are at the forefront of discussions at this year’s Medica Labmed Forum.
Hyperbaric oxygen therapy (HBOT) treatments could offer relief to breast cancer patients who experience late toxicities following radiotherapy treatment. To date, the handful of completed clinical trials only produced inconclusive or contradictory results. Therefore, results from the latest trial, named HONEY (Effect of Hyperbaric Oxygen Therapy on Breast Cancer Patients with Late Radiation…
Multiplex imaging can play a critical role in unravelling the tumour microenvironment. The potential and benefits of the emerging approach – a way to extract information from human tissue samples by visualising many more biomarkers than traditional microscopy – was highlighted in presentations during the 36th European Congress of Pathology in Florence, Italy. Speakers also discussed novel…
New insights gained from 3D cell cultures of breast and prostate cancer grown on the International Space Station (ISS) National Laboratory could lead to a way to treat not just these but all cancers.
In many cases, metastatic breast cancer is still incurable. To improve the odds, researchers have now analyzed the diversity of metastatic cells and their interactions with their cellular environment.
Tumor cells are notorious for their rapid and uncontrolled division, and many cancer therapies aim to disrupt this. New findings suggest potential applications of apoptosis in blood cancer treatment.
New technology shows promise in protecting an implant against infections from resistant bacteria: By heating up small nanorods of gold with near-infrared light (NIR), the bacteria are killed.
A new method could open new avenues to quick, affordable cancer diagnosis, US researchers report. The method uses ultrathin membranes to capture extracellular vesicles.
A new discovery about how the liver flushes cholesterol from the body could lead to more effective treatments for cardiovascular disease – the leading cause of death worldwide.
A ‘mini-protein’ can deliver radiation doses directly to tumours without harming healthy tissues. The approach shows promise for the treatment of metastatic bladder cancer and other tumours.
New insights into metastasis: Scientists created a 3D-printed model to mimic the specific conditions that spur the spread of cancer cells. This could help discover new screening and treatment options.
Immunotherapy has become the most promising strategy for treating several cancers, but its effectiveness is still very uneven. Three researchers explain how research is being done to change this.
A study led by Assistant Professor Masamitsu Sone and Professor Yoshifumi Yamaguchi from Hokkaido University, Japan, has uncovered a crucial gene that enables hibernating Syrian hamsters (Mesocricetus auratus) to prevent cold-induced cell death. The research was published in the journal Cell Death and Disease.
A new study found that measuring circulating tumor cells (CTCs), rare cancer cells shed from tumors into the blood, is a reliable way to predict later treatment response and survival prospects with metastatic prostate cancer.
The study findings of a team from Julius-Maximilians-Universität Würzburg (JMU) in Bavaria, Germany help to broaden the conceptual view on the DNA damage response and to link it more closely with RNA metabolism.
By combining mass spectrometry and mass cytometry imaging techniques, researchers can now dive deeper into tumors and map the metabolism of individual cells in tumor tissue.
Scientists at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue.
Researchers have succeeded in identifying patterns of response to treatment in patients with multiple myeloma using AI tools, which helps to accurately predict the evolution of the tumor.
A newfound molecule, called ACBI3, could potentially lead to new therapies against hard-to-treat cancers, improving outcomes for all patients with cancers caused by KRAS mutations.
A bit more mucus in the nose, a little less air in the gut: Even small changes can be important when planning proton therapy against cancer. A new workflow allows for an adapted irradiation every day.
A new study confirms fibrosis as a prognostic indicator in HER2-negative, the most common breast cancer, and opens the way to antifibrotic drug treatments.
STAb-T, a new form of immunotherapy to treat solid tumours shows therapeutic potential in animal models with non-small cell lung cancer. The new strategy is designed to strengthen the defensive cells.
Researchers identified the genetic background of the previously known but mysterious AnWj blood group antigen. The findings allow identification and treatment of patients lacking this blood group.
Only 20-40% of patients respond positively to immunotherapy, and these rates vary across different types of cancer. Researchers now identified five key factors that determine response and survival.
Currently, it is difficult to predict whether a cancer patient will respond to immunotherapy or not. A new method to quantify the heterogeneity of the tumour microenvironment aims to improve this.
Researchers have identified fibrotic scarring as a key source of resurgence of glioblastoma multiforme (GBM). The new insights could lead to better prevention of this type of brain cancer.
A US-Swiss team leverages AI and molecular simulations to uncover new pathways for precision cancer treatments, paving the way for more effective, personalized therapies.
Researchers propose the use of molecular ‘cages’ (made of pseudopeptides) to selectively eliminate cancer cells in acidic microenvironments. This could help reduce side effects from chemotherapy.
A new method of analysing the crystals in dehydrated blood could lead to a quicker, cheaper and less painful technique to diagnose, early detect, and monitor prostate cancer.
Researchers have developed an artificial intelligence which can differentiate cancer cells from normal cells, as well as detect the very early stages of viral infection inside cells.
The time of day can be an important aspect to consider for cancer therapy. Researchers from Charité are developing new methods to use the internal clock inside tumor cells to optimize treatments.
Cologne researchers have developed an AI-based digital pathology platform to enable extremely fast and accurate fully automated analysis of tissue sections from lung cancer patients.
After breast cancer surgery, radiotherapy helps prevent the cancer from returning. However, this protection does not last forever. A long-term study shows the duration of the treatment's benefits.
Can a look at a patient's DNA predict progress of their colorectal cancer? Findings from a new study could lead to improved possibilities for individualised therapies.
