Should tracheobronchial anastomoses be routinely wrapped following resection and reconstruction? A new study revisits this unresolved question in airway surgery.
Is osteoarthritis really an inevitable side-effect of an ageing body? New research challenges the idea of mechanical wear of joints as the cause of this painful condition.
People at risk of cardiovascular disease could be identified a decade before they have a heart attack or stroke, a new University of Dundee study has discovered.
Using an advanced PET scanner, US radiologists explore how cancer, neurodegenerative diseases and other systemic conditions, can affect the brain by assessing the impact on the blood-brain barrier.
Pancreatic cancer is one of the most aggressive cancers, partly due to its tumor microenvironment, known as the stroma. Now, a study has identified a new key factor contributing to this feature.
Due to the effects of climate change, dengue is spreading worldwide. Now, researchers have developed a 'dengue-on-a-chip' model that helps study the virus more effectively.
Researchers have succeeded in mapping how blood vessels in the brain react after a stroke. This new insight can lead to more effective treatment and fewer complications for patients.
Losing weight is a great way to improve one's overall health. But, are these benefits gone once a person is gaining weight again? Not necessarily, a new study points out.
Engineers developed a robotic probe that can generate high-resolution 3D ultrasound images from deep inside the gastrointestinal tract. The robot reaches its target with a unique kind of movement.
New findings show how AI-assisted mammography may not only reveal breast cancer, but can also assess calcium buildup in the arteries within breast tissue—an indicator of cardiovascular health.
Researchers developed a new scanning method that combines light and ultrasound to non-invasively monitor cerebrovascular changes in the early stages of an ischemic stroke in real time.
Life cycle assessment of bypass surgery procedures reveals opportunities to reduce the ecological footprint of healthcare, from reducing disposable materials to improving energy efficiency.
A new AI-based approach can predict whether people with type 2 diabetes are likely to develop chronic kidney disease years before symptoms arise, allowing for earlier intervention and treatment.
New research uncovers the hidden diversity of adrenal gland tumors, shedding light on how they cause unusual medical symptoms and paving the way for new drug treatments.
Traumatic brain injury (TBI) increases dementia risk, but the reasons are poorly understood. Now, a study explores the role of the brain's blood vessels as drivers of Alzheimer's disease.
While thrombectomy to remove blood clots after a stroke is increasingly performed, new research suggests that it may not be needed in all cases.
Research suggests a new approach to detecting Alzheimer’s disease: changes in brain oxygenation dynamics and neuronal function contribute to the neurodegeneration.
A new blood test that detects a specific brain protein may help doctors determine the type of a stroke faster and allow them to start safe treatment for people before they get to the hospital.
A new study has shown that the molecular signature of long Covid can be found in blood samples of children. Using an AI tool, the researchers were capable of diagnosing the condition with 93% accuracy.
A new deep learning model shows promise in detecting and segmenting lung tumors. The findings of the study could have important implications for lung cancer treatment.
Using a technique called field-cycling imaging (FCI) derived from MRI, researchers are able to detect signs of brain damage from stroke at ultra-low magnetic fields.
A new study shows that a simplified, low-field MRI machine, augmented with machine learning tools, matches conventional MRI in measuring brain characteristics relevant to Alzheimer's disease.
New research has linked having a cerebral stroke to lasting changes in the arteries in the abdomen. The study in animal models with hypertension could lead to new preventative strategies.
A traumatic brain injury (TBI) affects children differently than adults, a new study shows. The researchers found that paediatric patients are more prone to damage of the smallest brain vessels.
Protection against blood clots: A new material, designed to mimic blood vessels, could allow for safer use of devices like catheters, stents, blood-oxygenation machines and dialysis machines.
Scientists have developed a novel method for deploying several magnetic miniature robots which can easily navigate through a 3D matrix resembling a network of blood vessels.
Highlights: Capillary Blood Collection GK –for small amounts of bloodThe system offers special advantages for the collection of blood samples from new-borns, children, elderly people and emergency patients, thus everywhere, where only small amounts of blood are availableThe test vessel is prepared on the entire inner surface. Besides, it can be used as centrifugal vesselThe capillary…
Highlights:Assists in the handling of capillaries and their targeted draining on POCT-analysers and test strips or into vesselsSuitable for different capillaries regarding measurements and preparationsAvailable individually or completed with capillaryHandling:Fix capillary in the PAC while using oneway glovesThe capillary is filled as usual – afterwards the thump is put gently on the upper…
An “out-of-this-world” project has the potential to transform the future of tissue engineering and liver transplantation through research conducted aboard the International Space Station (ISS).
A new study confirms fibrosis as a prognostic indicator in HER2-negative, the most common breast cancer, and opens the way to antifibrotic drug treatments.
Researchers have identified fibrotic scarring as a key source of resurgence of glioblastoma multiforme (GBM). The new insights could lead to better prevention of this type of brain cancer.
Brain aneurysms cause around 500,000 deaths globally each year and can lead to stroke and disability. Now, researchers created nanoscale robots to manage bleeds in the brain caused by aneurysms.
For coronary artery bypass grafting (CABG), a ‘no-touch’ technique to harvest the saphenous vein graft has been considered superior to the conventional approach. Surprisingly, a new study comes to a different conclusion.
Using a melt electrowriting (MEW) technique, bioengineers have developed a hybrid structure to address the clinical need for small-diameter vascular grafts and help combat cardiovascular disease.
Extensive and moderate, or short and intense? New research suggests which approach to physical exercise is more effective for improving fitness among people recovering after a stroke.
Dermatologists could benefit from a new algorithm that can help recognize patients with a highly aggressive form of basal cell carcinoma (BCC) of the face.
Researchers discovered islands of highly potent immune cells in the vicinity of glioblastomas. This may open up prospects for new therapies for these aggressive brain tumours.
Using vascular organoids derived from stem cells, researchers gain new insights into how diabetes damages blood vessels. This could lead to to the development of new treatments.
Why do aortic aneurysms form where they typically do, at the upper arch or in the abdominal cavity? A new study explores the predilection of these sites for vascular dilatations.
Neurosurgeons have developed a minimally invasive surgical technique to remove lesions in the petrous apex. The method provides a new approach to these notoriously diffcult-to-remove tumors.
Researchers demonstrated how the growth of malignant brain tumours can be greatly decreased by using iontronic technology to continuously administer low doses of cancer drugs.
In lab models of stroke, a research team showed that laser therapy improved blood flow in the brain and decreased stroke injury by stimulating the production of nitric oxide.
A new 3D graft printing technique offers a potential solution to reduce thrombosis and restrain aneurysmal dilatation post-surgery, with potential for improving cardiovascular disease treatments.
Microbubbles in a contrast agent allows for ultrasound imaging of the finest vascular details. This is the working principle of a technique called ultrasound localization microscopy (ULM).
Autonomous robotic ultrasound systems could perform routine examinations and support doctors in the OR. New research shows that these systems can make everyday life easier for medical professionals.
Researchers were able to produce sub-millimetre resolution images of cardiac micro-vessels. This non-invasive new technique could allow scientists to study the physiology of the heart in more detail.
Diamond dust could be used in MR imaging, a surprising find shows. The nanometer-sized particles could serve as an alternative to the controversial contrast agent gadolinium.
After a stroke or heart attack, the risk of infection is increased – however, why this happens was unknown. Now, researchers found a previously unknown cause – and a therapeutic approach.
Coronary artery disease causes more than 1.8 million heart attacks each year in Europe. In most cases, rehabilitation helps the patients to return to their everyday life. But what happens once the patients have left the rehab clinic?
Decreased rates of death and stroke: new research shows the validity of transcatheter aortic valve replacement in low-risk patients. This advocates a less invasive alternative to surgical options.
Catheter ablation of atrial fibrillation is an important treatment option for heart rhythm maintenance and symptom reduction. Now, an international consensus statement reflects new techniques.
Using 3D bioprinting to accurately replicate the biological environment surrounding gastric cancer cells, researchers predicted a patient’s response to anticancer drugs during the preclinical stage.
Much like joints or blood vessels, the brain can be affected by calcifications. This can lead to neurodegenerative disease, but is not well studied. Now, researchers from Norway identified a gene that provides new insights.
US oncologists are exploring a new combined chemotherapy and surgical approach to safely remove advanced pancreatic tumors that were previously considered inoperable.
Warfarin is sometimes prescribed after heart surgery, but getting the dose right requires a personalised approach for each patient. A new AI tool is designed to help with this complex task.
An innovative solution based on nanotechnology and ultrasound could prevent over-treatment of patients with rectal cancer. The magnetomotive ultrasound system uses nanotechnology for reliable diagnosis of any spread of rectal cancer to nearby lymph nodes.
Using light instead of x-rays, a new imaging method from Philips is designed to advance navigation through a patient's blood vessels during minimally-ivasive procedures.
Researchers have identified how cells work to resolve "frozen shoulder", a painful and disabling condition affecting the ligaments that form the shoulder joint capsule.
Material scientists at TU Wien (Vienna) have developed a new approach to producing artificial cartilage tissue: using a 3D printer, cells are grown in microstructures.
Chemotherapy can be toxic to heart cells. To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional “heart-on-a-chip” to evaluate drug safety.
AI models are highly capable in analysing tissue samples – as long as conditions are lab-perfect. Add a little contamination, however, and diagnostic accuracy goes out the window, a new study shows.
A Korean research team has advanced the imaging of kidney diseases using ultrafast ultrasound that captures 1,000 images in just one second.
Canon Medical Systems Corporation and Olympus Corporation announced that they have reached an agreement to collaborate on Endoscopic Ultrasound Systems, and presented a new imaging system.
An Italian research team has introduced a new MRI-based method for assessing water water exchange to estimate the degree of malignancy and the success of treatments in tumors.
Dutch researchers successfully inserted magnet-controlled miniature robots into an aorta model with kidneys. In the future, this technology could be used to remove blood clots.
Using AI and optoacoustic imaging, researchers have developed a new method to assess microvascular changes in the skin – and thus the severity of diabetes in the patient.
It's an important milestone for gene editing technology: a novel treatment for sickle cell disease utilizing CRISPR-Cas9, has now received FDA approval – a first for this type of therapy.
White blood cells found in breast tumors can both help and hinder the spread of cancer cells to other organs, a new study from Karolinska Institutet shows.
Using small blood vessels grown in the lab, researchers discover how vascular leaks leading to dementia and stroke emerge – and how this damage might be fixed.
Chronic wounds in diabetes patients are often slow to heal, which can lead to serious infections and even limb amputation. Now, researchers propose to address this with a magnetic wound-healing gel.
Postpartum hemorrhage is a leading cause of maternal mortality at birth, especially after cesarean deliveries. Now, anesthesiologists propose two simple solutions to help prevent the severe bleeding.
Neurologists at Amsterdam UMC have developed a special sensor cap that interprets EEG brain waves to early detect signs of an ischemic stroke while the patient is in the ambulance.
Stark inequalities in diagnosis and treatment of four of the most common heart conditions in the UK have been revealed in new research led by a team at the University of Leeds.
New research led by Brigham and Women’s Hospital unveils that women who struggle with getting enough sleep might be at greater risk of developing hypertension, or high blood pressure.
A European team of researchers have successfully developed a new, living organ model which could advance rapid testing of new or common drugs to treat diseases of the liver.
Researchers at the University of Michigan have zeroed in on Candida auris – a fungus with the uncanny ability to stick to everything from skin to catheters – and made a startling discovery.
A team from UNC has developed a steerable lung robot that can autonomously maneuver the intricacies of the lung, while avoiding important lung structures.
Cardiologists in Zurich demonstrate that immediate revascularization of non-involved blood vessels offers better outcomes for patients after a heart attack than a delayed procedure.
A new approach to treating kidney failure could one day free people from needing dialysis or having to take harsh drugs to suppress their immune system after a transplant.
New technology that creates ultra-thin layers of human cells in tube-like structures could spur development of lifelike blood vessels and intestines in the lab.
A family physician at Tufts University School of Medicine offers advice for how to treat allergies and how to tell if symptoms are due to allergies, the common cold, the flu, or Covid-19.
While screening programs for several of the commonest cancers are now well established, lung cancer screening has yet to reach anywhere near the same proportion of at-risk patients.
Researchers at Mayo Clinic have developed a 3D prototype of human skin bioprinted to model inflammatory skin disease such as atopic dermatitis — more commonly known as eczema.
Combining two types of heart scan techniques could help doctors to detect deadly hypertrophic cardiomyopathy (HCM) before symptoms and signs on conventional tests appear.
Patients with heart disease could benefit from less extensive interventions thanks to technology that creates 3D computer models of blood flow through the heart's arteries, according to new research.
A new method for cheaply producing heart valves in the span of minutes shows great promise. The scientists describe the method as "a cotton-candy machine with a hair dryer behind it."
A new real-time imaging technique that uses a type of infrared light has, for the first time, been used during surgery to differentiate between cancerous tumours and healthy tissue.
Using imaging guidance, interventional radiology – a sub-discipline of diagnostic imaging – allows targeted and ultraprecise diagnostic and therapeutic procedures without anesthesia and without large incisions. Nevertheless, surgery continues to be widely considered the procedure of choice, making interventional radiology the Cinderella of the discipline. Professor Dr. Marco Das, Medical…
Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction.
Researchers have developed a new tool and technique that uses “vortex ultrasound” – a sort of ultrasonic tornado – to break down blood clots in the brain.
It was previously assumed that bones lacked lymphatic vessels.Now, new research not only locates them within bone tissue, but demonstrates their role in bone and blood cell regeneration.
For almost four decades, stroke cases and fatalities have been on the decline. In recent years, however, signs point to a resurgence, according to an analysis of US stroke deaths from 1975 to 2019.
Scientists have discovered a way to train healthy immune cells to acquire the skills of some tumor cells for a good purpose: to accelerate diabetic wound healing.
Both hot and cold environments trigger a stress response and can lead to cardiovascular problems. Results of a new study are especially interesting in light of the current multiple global crises.
Treating pancreatic cancer patients with chemotherapy before surgery significantly improved 1-year survival rates compared to immediate surgery, a randomised clinical trial has found.
Canadian researchers have developed a new method of killing brain cancer cells while preserving the tissue around it. A remarkable side-benefit: chemotherapy of the cancer suddenly becomes possible.
For the first time, a new study has identified enlarged perivascular spaces in the brains of migraine sufferers. Results of the study will be presented at the annual RSNA meeting.
One robot supports the surgeon’s control of tiny instruments, while another automatically keeps an eye on what is happening: With this novel combination, surgeons in Münster have successfully performed fully robot-assisted microsurgery for the first time. Presenting the new procedure at the Hornheide Specialist Clinic, the experts explain how the interaction of both robotic systems ensures…
A new X-ray technology has been used to identify a link between the damage that severe Covid-19 can inflict on lungs and pulmonary fibrosis, a disease that causes severe scarring of lung tissue.
White matter hyperintensities (WMH) on the brain seen on MRI represent a biomarker associated with a 50/50 risk of death within five years after a first incident acute ischemic stroke (AIS) or transient ischemic attack (TIA).
The risk of developing breast cancer is higher in breasts with high density. But why is that? Researchers at Linköping University have shown major biological differences that promote cancer growth.
Treatment of central nervous system diseases and tumors is often hindered by the blood-brain barrier. A new method aims to overcome this obstacle using focused ultrasound intranasal delivery (FUSIN).
Not just uncomfortable, but hard on the heart: Accumulating research suggests a link between hot flashes during the menopause and cardiovascular disease risk in women.
Cambridge scientists have discovered that cancer cells ‘hijack’ a process used by healthy cells to spread around the body, completely changing current ways of thinking around cancer metastasis.
A research group has revealed that SARS-CoV-2 disrupts the vascular endothelial barrier by suppressing the expression of Claudin-5 (CLDN5) to invade the blood vessels.
The oncogene EVI1 causes an aggressive type of leukemia, but its exact function has been a mystery. A research team now showed that EVI1's cancer causing effect relies on activating a single gene — the stem cell transcription factor ERG.
An important prospective study showcases improvement in outcomes for women with ischemic heart disease by attending a multidisciplinary women’s health center.
German researchers present a novel method for testing chemical agents that could help in the development of drugs against neurodegenerative diseases such as Alzheimer's.
Two-dimensional (2D) cultured cell lines and animal models have been the principal research tools for the past decade, but have several shortcomings. Three-dimensional cell cultures, or organoids, show great promise here.
A research team has created the first gel-based cartilage substitute that is even stronger and more durable than the real thing, offering a promising solution for patient suffering from knee pain.
Researchers at McMaster University create device to replicate conditions in blood vessels after grafts.
The main goal of arthroplasty is to relieve pain, improve and restore joint function and recover quality of life. Periprosthetic joint infection remains a complication that has to be taken seriously.
Functional ultrasound localization microscopy (fULM) captures the cerebral activity at the micron-scale, opening up major future clinical perspectives for the diagnosis of cerebrovascular pathologies.
As knowledge about Covid-19 advances, so does the arsenal of techniques to predict, diagnose and follow up on the disease. At ECR, researchers presented a range of promising imaging modalities to keep track of Covid-19 symptoms, severity, and mortality, often including AI support to enhance or accelerate diagnostics.
A spin-off from ETH Zürich has developed a magnetically steerable catheter for quick and safe stroke treatment that no longer requires surgeons to be on site.
Patients are 20% less likely to die of sepsis because a new AI system developed at Johns Hopkins University catches symptoms hours earlier than traditional methods, an extensive hospital study shows.
Similar to the way exercise helps muscles adapt to workouts, short, repeated bouts of reduced circulation with a blood pressure cuff may help prevent the worst outcomes of heart attacks and strokes.
Networks adapt over time and in this way form a kind of memory. German researchers show that the structure of blood vascular network is dynamic and can adapt to external factors.
Using functional MRI with inhaled xenon gas, researchers have identified that long COVID symptoms are related to microscopic abnormalities that affect how oxygen is exchanged from the lungs to the red blood cells.
When every minute counts: A Swiss team is currently developing a diagnostic procedure that can be used to start a tailored therapy for acute stroke in a timely manner.
Researchers have developed a biodegradable gel that can help to improve the delivery of cells into the living heart and could form a new generation of treatments to repair heart attack damage.
Newly engineered in vitro tumour models open ways to better understand the crosstalk between liver cancer cells and their microenvironment, researchers from Singapore found.
When a virus makes its way into the body, one of the immune system’s first responders is a set of pathogen-removal cells called macrophages. But they don’t all target viruses in the same way.
A special type of MRI found lung abnormalities in patients who had previously had COVID-19, even those who had not been hospitalized with the illness.
In patients with serious and long-term Covid-19, disturbed blood coagulation is often observed. Now, Swedish researchers found a connection between harmful amyloid production and Covid-19 symptoms.
Cerebral white matter hyperintensities (WMH) can have a devastating impact on a patient’s life. Radiologists must learn to recognise these white spots in the brain and conventional imaging may just reveal the tip of the iceberg.
Advances in image post-processing and contrast-enhanced techniques have widened the scope of possibilities for MRI and ultrasound vascular imaging, experts showed in a dedicated course at the ECR Overture.
Two successive studies highlight advances in non-invasive 3D ultrasound imaging, making it possible to observe blood flow in real time in the heart and the brain.
Scientists at the La Jolla Institute for Immunology discover new drug target for severe asthma and fibrosis.
Cognitive impairment as a result of severe Covid-19 is similar to that sustained between 50 and 70 years of age and is the equivalent to losing 10 IQ points, scientists found.
Recently, a Korean research team has developed a 3D foot imaging technique that vividly captures peripheral blood vessels, even thinner than 1 mm. It combines photoacoustic and ultrasound images.
An international team has for the first time demonstrated that nerve signals are exchanged between clogged up arteries and the brain.
A team led by scientists from Amsterdam have combined MRI and microscopy to produce 3D images of two entire brains with a previously unmatched level of detail.
An international research team has now found an approach to lower the activation of hepatic stellate cells (HSCs) and reduce the associated development of liver fibrosis.
A protein vital in determining the organs affected by metastasis has been identified by Swiss researchers. This could lead to the development of therapeutic approaches to suppress metastasis.
Cedars-Sinai physician-scientists are pioneering imaging techniques and investigating new biomarkers to improve multiple sclerosis (MS) diagnosis and treatment.
Engineers at the Massachusetts Institute of Technology (MIT) have developed a telerobotic system to help surgeons quickly and remotely treat patients experiencing a stroke or aneurysm.
A chip-based infection model developed by Jena researchers enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis.
Researchers from Charité – Universitätsmedizin Berlin have shown that massive electrochemical waves in the brain act as a marker announcing an impending ischemic stroke.
For people with atrial fibrillation, one of our most common cardiac disorders, dementia risk is elevated.
3D-printed sugar models of dense and chaotic blood vessel networks near tumors could help future cancer treatments.
Scientists are developing a novel method for treating brain haemorrhages which it is hoped could reduce the risk of brain damage and disability and increase patients’ chances of survival.
The AI-Guided Ultrasound Intervention Device is a lifesaving technology that helps a range of users deliver complex medical interventions at the point of injury.
For a long time, the origin of metastasis remained obscure. Now, scientists have discovered some of the mechanisms these cells arise.
A new study has analyzed over 3000 proteins to identify which are causally linked to the development of severe Covid-19. This provides insight into potential new targets for treatment and prevention.
A new study has proved that it is possible to convert blood type safely in donor organs intended for transplantation. This is an important step towards creating universal type O organs.
French researchers have found a way to facilitate access to tumours for killer lymphocytes, paving the way for more efficient immunotherapies against cancer.
A literature review fleshes out key issues currently preventing the proliferation of robotic procedures, specifically their use in image-guided interventional procedures in the brain.
Esslingen is one of the most innovative regions worldwide. Thus, it does not come as a surprise that Esslingen‘s 660-bed hospital is interested in adopting cutting-edge technology. A surgical robot, to be precise.
When a patient suffers a stroke, speed in treatment can mean the difference between successful recovery, permanent disability, or death. For Christopher Hess, success in stroke diagnosis is a question of workflow and efficient care delivery.
One of the crucial future technologies in surgery is Augmented Reality (AR). Most experts agree that AR will increase safety and efficiency, improve surgical training and decrease costs.
A novel protein regulator of tumor angiogenesis, TMEM230, was recently characterized by researchers to have a role in tumor development and vascularization, with potential as a target for anti-tumor therapy in difficult-to-treat cancers such as glioblastoma.
Researchers at the McKelvey School of Engineering at Washington University in St. Louis found a way to significantly reduce the noise and maintain image quality while reducing the laser energy needed to generate images by 80%.
Since Compamed could only be held digitally last year, due to the pandemic, the event now takes place publicly again. Almost 500 registrations from exhibitors prove that there is a high level of interest from medical technology suppliers – a huge step towards reaching normality again.
Speed in treatment of ischemic stroke can mean the difference between successful recovery versus permanent disability caused by brain tissue damage or death. Time is of the essence to perform thrombolysis with a tissue plasminogen activate (tPA), a protein that can dissolve blood clots causing the stroke or intra-arterial thrombolytic therapy (IAT) because of large-vessel occlusion.
A commonly available imaging technique can identify stroke patients most likely to benefit from a procedure to restore blood flow, a potential breakthrough in care that could save thousands of lives every year
Treating diseases such as Alzheimer’s or Parkinson’s is a challenge because drugs have to be able to cross the blood–brain barrier. As a result, the doses administered must be high and only a small fraction reaches the brain, which can lead to significant systemic side effects.
The damage caused by Covid-19 to the lungs’ smallest blood vessels has been intricately captured using high-energy X-rays emitted by a special type of particle accelerator. Scientists used a new imaging technology called Hierarchical Phase-Contrast Tomography (HiP-CT), to scan donated human organs, including lungs from a Covid-19 donor.
The mechanisms by which the body measures temperature and regulates its own body heat are vital, but still poorly understood. The discovery of the first heat sensor on nerve cells in the skin, for which the U.S. molecular biologist David Julius received this year's Nobel Prize for Medicine, was therefore pioneering. However, a very similar heat sensor, the protein TRPM2, is active not only in the…
The first investigational transplantation of a genetically engineered, nonhuman kidney to a human body was recently completed at NYU Langone Health—marking a major step forward in potentially utilizing an alternative supply of organs for people facing life-threatening disease.
Researchers at Durham University are working on a new infrared light therapy that might have the potential to help people with dementia. In the approach, people wear a specially adapted helmet which delivers infrared light deep into the brain for six-minutes per treatment. This stimulates mitochondria that generate most of the chemical energy needed to power the biochemical reaction in the…
Blood transfusions save lives, yet the precious fluid is in desperately short supply around the globe. But what if transfusions don’t always require blood? A new mathematical model of the body’s interacting physiological and biochemical processes – including blood vessel expansion, blood thickening and flow-rate changes in response to the transfusion of red blood cells – shows that…
Researchers have found a possible explanation for why some patients recover much more poorly from brain injury if they later become infected.
Customizable to individual patients and requiring less than 10 minutes to prepare and use, new surgical implant coating prevented 100% of infections in mice.
Scientists from the German Cancer Research Center (DKFZ) and the Medical Faculty Mannheim, Heidelberg University, have identified a new growth factor produced by blood vessels that enables tumor cells to metastatically colonize organs.
Combining imaging modalities is helping to achieve better diagnostic and therapeutic outcomes for heart patients. The topic, discussed in detail by experts at the ICNC-CT online International Conference on Nuclear Cardiology and Cardiac CT, examined hybrid/fusion imaging as the standard in cardiovascular imaging, and its value in clinical practice. Professor Terrence Ruddy spoke about the role of…
People who work night shifts are at increased risk of developing an irregular and often abnormally fast heart rhythm called atrial fibrillation (AF), according to research published in the European Heart Journal. The study is the first to investigate the links between night shift work and AF. Using information from 283,657 people in the UK Biobank database, researchers found that the longer and…
Researchers at Tel Aviv University have 3D-printed a first-of-its-kind glioblastoma tumor that mimics a living cancer malignancy, powering new methods to improve treatment and accelerate the development of new drugs for the most lethal type of brain cancer. Glioblastoma is notoriously fatal as it accounts for the majority of brain tumors and is highly aggressive. The average survival time of…
A new study of patients with cerebral venous thrombosis (CVT) following Covid-19 vaccination provides a clearer guide for clinicians trying to diagnose and treat patients. The research, led by University College London (UCL) and UCL Health and published in The Lancet, is the most detailed account of the characteristics of CVT, when it is caused by the novel condition vaccine-induced immune…
Covid-19 disease severity is determined by the individual patient’s immune response. The precise mechanisms taking place inside the lungs and blood during the early phase of the disease, however, remain unclear. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität Berlin have now studied the cellular mechanisms…
Researchers have found a way to reduce organ rejection following a transplant by using a special polymer to coat blood vessels on the organ to be transplanted. The polymer, developed by Prof. Dr. Jayachandran Kizhakkedathu and his team at the Centre for Blood Research and Life Sciences Institute at the University of British Columbia, substantially diminished rejection of transplants in mice when…
Nanocontainers can transport substances into cells where they can then take effect. This is the method used in, for example, the mRNA vaccines currently being employed against Covid-19 as well as certain cancer drugs. In research, similar transporters can also be used to deliver labelled substances into cells in order to study basic cellular functions. To take advantage of their full potential,…
Using lab-created tissue to heal or replace damaged organs is one of the great visions for the future of medicine. Synthetic materials could be suitable as scaffolding for tissue because, unlike natural tissues, they remain stable in the organism long enough for the body to form new natural structures. A fundamental requirement for functional tissue is that blood vessels must be able to grow in…
Researchers at the Medical Faculty of the University of Freiburg have developed an improved therapeutic approach to resuscitate people after cardiac arrest - often without neurological complications. Around 50,000 people suffer sudden cardiac arrest in Germany every year. When occurring outside a hospital, the chances of survival are only ten percent. Survivors often suffer from severe permanent…
Magnetic fields can be used to stimulate blood vessel growth, according to a new study. The findings, published in the journal Science and Technology of Advanced Materials by researchers at the Técnico Lisboa and NOVA School of Science and Technology in Portugal, could lead to new treatments for cancers and help regenerate tissues that have lost their blood supply.
The tell-tale signs of a person’s susceptibility to a stroke may appear up to 10 years before the event, suggests research published online in the Journal of Neurology Neurosurgery & Psychiatry. Stroke patients experienced much steeper declines in cognitive abilities and routine daily functioning, starting around a decade before their first stroke, than people who didn’t have a stroke,…
A study involving virtual rather than real patients was as effective in evaluating a medical device used to treat brain aneurysms, according to new research. The findings are proof of concept for what are called in-silico trials, where instead of recruiting people to a real-life clinical trial, researchers build digital simulations of patient groups, loosely akin to the way virtual…
After a stroke, doctors can try to remove clots in blood vessels to keep blood flowing freely to the brain. But even though most of these procedures are successful, less than half of people have a successful recovery from the stroke. A new study published in the medical journal Neurology sheds light on why that may be. The study found that trying more than once during a procedure to retrieve a…
A new positron emission tomography (PET) radiotracer can detect abdominal aortic aneurysms (AAAs) and potentially predict when they will rupture, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting. Targeting a novel biomarker associated with AAA, the radiotracer is effective both in diagnosis and in providing information to assist in the…
Statin use among patients with heart failure is associated with a 16% lower risk of developing cancer compared with non-statin users during an average of four years of follow-up. This is according to new research published in the European Heart Journal. In addition, the study found that statin use was associated with a 26% reduced risk of dying from cancer over the same period.
Interdisciplinary team from Washington University School of Medicine in St. Louis and the university’s McKelvey School of Engineering finds better way to design clot-prone grafts currently used for dialysis.
Inspired by kirigami, the Japanese art of folding and cutting paper to create three-dimensional structures, MIT engineers and their collaborators have designed a new type of stent that could be used to deliver drugs to the gastrointestinal tract, respiratory tract, or other tubular organs in the body.
Scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.
New artificial intelligence (AI) technology to scan for heightened blood vessel inflammation can calculate a person’s risk of death from Covid-19 and its variants.
A simple blood test could help doctors spot deadly damage to the aorta, the body’s largest blood vessel, according to research funded by the British Heart Foundation (BHF) presented at the British Cardiovascular Society conference.
For the first time, a prospective, international study has shown that chest pain caused by problems with the very small vessels supplying blood to the heart is an important health problem that increases the risk of heart attacks, stroke and death due to cardiovascular reasons. The study, which is published in the European Heart Journal, recruited 686 patients from 14 institutions in seven…
In Germany, more than 200,000 people suffer a heart attack every year. Despite good medical care, many are left with reduced cardiac output. This is particularly true for patients with severe heart attacks: more than 30 percent of those affected develop heart failure, and almost half of them die within the next five years. Experts at the Department of Cardiology and Angiology at Hannover Medical…
Handheld laser devices that help surgeons quickly spot liver damage could transform transplant procedures, research suggests. The non-invasive technique could provide medical staff with instant data on the health of donor livers and help them to identify which organs are suitable for transplant. If widely adopted, the light-based tool could allow more livers to be transplanted safely and…
Spinal fusion is frequently performed to restore spinal stability in patients with spinal diseases, such as spinal stenosis, vertebral fractures, progressive deformities, and instability. In the past two decades, there has been marked increase in the number of people over 65 years in age who have needed spinal fusion surgery.
A collaboration spanning four research labs and hundreds of miles has used the organ-on-a-chip (Organ Chip) technology from the Wyss institute at Harvard Univesity to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes Covid-19. The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the…
A new photonics device currently in development aims to reduce unnecessary disabilities by improving the instant, real-time monitoring of newborn babies with harmless light particles.
First you see it as a transparent shape on a computer screen – a small electronic replica of the human pancreas. Then just 30 seconds later the tissue is printed out on a bioprinter, blood vessels and all, from a sample of human stem cells. This amazing feat is possible thanks to new technology created at EPFL’s Laboratory of Applied Photonics Devices (LAPD) and further developed by…
With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs. A team of researchers at the College of Medicine at the University of Oklahoma has published a new study in the journal…
Researchers at the Human Genome and Stem Cell Research Center (HUG-CELL), hosted by the University of São Paulo’s Institute of Biosciences (IB-USP) in Brazil, have developed a technique to reconstruct and produce livers in the laboratory. The proof-of-concept study was conducted with rat livers. In the next stage of their research, the scientists will adapt the technique for the production of…
The first known study to measure SARS-CoV-2 viral load in a variety of organs and tissues may aid our understanding of how Covid-19 develops following infection.
Magnetic resonance imaging (MRI) is widely used to identify the narrowing or blockage of blood vessels. Contrast agents improve the visibility of the structures and offer more accurate information of vascular conditions such as vascular blockage and stenosis. Commonly used gadolinium-based contrast agents must be administered in chelated forms due to the gadolinium ions' high toxicity and pose…
Our brains are non-stop consumers. A labyrinth of blood vessels, stacked end-to-end comparable in length to the distance from San Diego to Berkeley, ensures a continuous flow of oxygen and sugar to keep our brains functioning at peak levels. But how does this intricate system ensure that more active parts of the brain receive enough nourishment versus less demanding areas? That’s a century-old…
Researchers at the Universitat Autònoma de Barcelona obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies.
Around 50% of patients who have been hospitalised with severe Covid-19 and who show raised levels of a protein called troponin have damage to their hearts. The injury was detected by magnetic resonance imaging (MRI) scans at least a month after discharge, according to new findings published in the European Heart Journal. Damage includes inflammation of the heart muscle (myocarditis), scarring or…
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modeling these complex interactions in animals such as mice is difficult to do, because their…
Olympus Corporation announced that it has entered into an agreement to acquire Quest Photonic Devices B.V. for up to EUR50 million including milestone payments to strengthen its surgical endoscopy capabilities. Quest offers advanced fluorescence imaging systems (FIS) for the medical field, enabling more surgical endoscopy capabilities, compared to conventional imaging technologies.
A study of nearly 108,000 people has found that people who regularly drink a modest amount of alcohol are at increased risk of atrial fibrillation, a condition where the heart beats in an abnormal rhythm. The study, published in the European Heart Journal, found that, compared to drinking no alcohol at all, just one alcoholic drink a day was linked to a 16% increased risk of atrial fibrillation…
Aneurysm operations in the brain rank among the most delicate procedures in neurosurgery. The highest demands are placed on surgeons when choosing the type of intervention, planning the route and carrying out extremely delicate procedures on the blood vessel. A new training technology co-developed between Inselspital, Bern University Hospital, and ARTORG Center of the University of Bern, will…
In some cases, immune cells in the lungs can contribute to worsening a virus attack. In a new study, researchers at Karolinska Institutet describe how different kinds of immune cells, called macrophages, develop in the lungs and which of them may be behind severe lung diseases. The study, which was published in Immunity, may contribute to future treatments for Covid-19, among other diseases.
Non-degradable prostheses for cardiovascular tissues can be used to replace heart valves and blood vessels, but they can’t stay in the body permanently. In two recent papers, researchers at the Eindhoven University of Technology (TU/e) in collaboration with a number of clinical partners, the Dutch Heart Foundation, and TU/e spin-off companies Suprapolix, Xeltis, and STENTiT have shown how…
Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue. To facilitate this step, cancer cells influence blood clotting, as scientists from the German Cancer Research Center and Heidelberg University Hospital have now been able to show in mice. The cancer cells actively promote the formation of clots, which helps them to arrest in the…
A recent preclinical study from scientists at Sunnybrook Research Institute, Canadian Blood Services and the University of Toronto has demonstrated that focused ultrasound improves the delivery of intravenous immunoglobulin (IVIg), a blood product composed of antibodies from healthy donors, previously shown to have potential in treating a subgroup of patients with Alzheimer’s disease.
A study of over a thousand cancer patients treated with immunotherapy drugs has found these patients are at greater risk of heart problems, including death from heart attack or stroke. The patients had either lung cancer or malignant melanoma (a type of skin cancer), for which immune checkpoint inhibitors such as a programmed cell death-1 (PD1) inhibitors or cytotoxic T-lymphocyte-associated…
Cancer cells spread by switching on and off abilities to sense their surroundings, move, hide and grow new tumors, a new study has found. This sensitivity to their surroundings is the key ability that makes small numbers of cancer cells better at spreading than other cells in a tumor.
According to Professor Fabian Bamberg, Medical Director at the Clinic for Diagnostic and Interventional Radiology at University Hospital Freiburg, Germany, ‘In recent years, cardiac CT has seen a mindboggling technological evolution.’ It is, he believes, a very robust procedure that allows the routine acquisition of high-resolution images with very few side effects.
Italian neurosurgeon Professor Francesco Di Meco, explored the current and potential role of intra-operative ultrasound in neurosurgical oncology during the annual meeting of the European Association of Neurosurgical Societies (EANS) this October. The extent of resection is considered a prognostic factor in operative neuro oncology surgery and image-guided surgery is being regarded as one of the…
Higher than normal blood pressure is linked to more extensive brain damage in the elderly, according to a new study published in the European Heart Journal. In particular, the study found that there was a strong association between diastolic blood pressure (the blood pressure between heart beats) before the age of 50 and brain damage in later life, even if the diastolic blood pressure was within…
The new generation troponin I assay unveiled by Beckman Coulter is helping improve heart attack diagnosis. Delivering high sensitivity, and rapid result turnaround times, every element of the Access hsTnI assay has been redeveloped and updated, including the antibodies and the paramagnetic particles used. As specialists in developing and manufacturing products that simplify and automate complex…
Alzheimer's disease is the most common cause of dementia. Still incurable, it directly affects nearly one million people in Europe, and indirectly millions of family members as well as society as a whole. In recent years, the scientific community has suspected that the gut microbiota plays a role in the development of the disease.
Asian ethnicity is strongly linked to COVID-related stroke, reveals an analysis of stroke centre activity in England and Scotland during the first wave of the coronavirus pandemic, and accepted for publication in the Journal of Neurology Neurosurgery & Psychiatry.
Specialists from the Department of Fundamental Medicine of Far Eastern Federal University (FEFU) with Russian and Japanese colleagues have probed into mechanisms of COVID-19 inside-the-body distribution linked to erythrocytes damaging.
A study conducted by Richard Vander Heide, MD, PhD, Professor and Director of Pathology Research at LSU Health New Orleans School of Medicine, and Marc Halushka, MD, PhD, Professor of Pathology at Johns Hopkins University School of Medicine, suggests myocarditis caused by COVID-19 may be a relatively rare occurrence.
Costantino Balestra, Professor of Physiology at Haute Ecole Bruxelles-Brabant in Belgium, uses point-of-care ultrasound (POCUS) in environments that could not be more different from a typical hospital setting. His expertise lies in studying the effects of extreme conditions on the human body, including temperatures, altitudes, and ambient pressures, for example, in deep oceans. One of his areas…
Researchers have found that a class of commonly-used heart drugs may also improve patients’ responses to anti-cancer immunotherapies called PD(L)1 inhibitors, according to preliminary findings to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics.
An up-and-coming gene therapy for blood disorders. A new class of medications for cystic fibrosis. Increased access to telemedicine. These are some of the innovations that will enhance healing and change healthcare in the coming year, according to a distinguished panel of clinicians and researchers from Cleveland Clinic. In conjunction with the 2020 Medical Innovation Summit, Cleveland Clinic…
Scientists at EPFL are using technology to better understand how coronavirus causes blood clots in some patients. They have developed a simplified model of a lung that lets them observe, for the first time, how the virus attacks the cells lining blood vessels.
Focused ultrasound waves help researchers at ETH Zurich to deliver drugs to the brain only to where their effect is desired. This method is set to enable treatment of psychiatric and neurological disorders and tumours with fewer side effects in the future.
Researchers at the German Center for Neurodegenerative Diseases (DZNE) and Charité - Universitätsmedizin Berlin have identified highly effective antibodies against the coronavirus SARS-CoV-2 and are now pursuing the development of a passive vaccination. In this process, they have also discovered that some SARS-CoV-2 antibodies bind to tissue samples from various organs, which could potentially…
Royal Philips announced that it has signed an agreement to acquire Intact Vascular, Inc., a U.S.-based developer of medical devices for minimally-invasive peripheral vascular procedures. Intact Vascular will enhance Philips’ image-guided therapy portfolio, combining Philips’ interventional imaging platform and diagnostic and therapeutic devices with Intact Vascular’s unique, specialized…
Sending a “selfie” to the doctor could be a cheap and simple way of detecting heart disease, according to the authors of a new study. The study is the first to show that it’s possible to use a deep learning computer algorithm to detect coronary artery disease (CAD) by analysing four photographs of a person’s face. Although the algorithm needs to be developed further and tested in larger…
The SARS CoV-2 virus which causes COVID-19 may have been named prematurely. As more has become known about the infection, the severe disease does not appear to be a respiratory syndrome at all. Patients who only have a respiratory illness tend not to have a severe condition, while patients who develop a severe condition tend to have non-respiratory conditions, primarily thrombotic or hyper-immune…
Injuries in the nervous system of patients with severe COVID-19 are revealed by magnetic resonance imaging (MRI) and computed tomography (CT). In a study of 185 patients, researchers at Karolinska Institutet (KI) and Karolinska University Hospital show an affection of microscopic blood vessels and inflammation in the brain, meninges and nerves. The results are published in Radiology.
The VeinViewer® uses harmless near-infrared (NIR) light which is directed towards the patient’s skin. Haemoglobin in the blood absorbs the NIR and the surrounding tissue reflects it back to the VeinViewer® device, where the data is processed into an image, colour is added and the image sent back to the skin to provide a real time visualization of the blood vessels and patterns up to 10mm…
L-type calcium channel blockers (LCCBs) — the most widely used drugs for treating hypertension — may harm the heart as much as help it, according to a new study. The research team, led by the Pennsylvania State University, found that in rats and human cells in vitro, LCCBs cause changes in blood vessels — known as vascular remodeling — that reduce blood flow and increase pressure.…
A team of researchers led by the University of Adelaide and University of Stuttgart has used 3D micro-printing to develop the world’s smallest, flexible scope for looking inside blood vessels. The camera-like imaging device can be inserted into blood vessels to provide high quality 3D images to help scientists better understand the causes of heart attack and heart disease progression, and could…
Johns Hopkins scientists report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye.
An overactive defense response may lead to increased blood clotting, disease severity, and death from COVID-19. A phenomenon called NETosi is part of an immune response that becomes increasingly hyperactive in people on ventilators and people who die from the disease.
Our body is able to treat many injuries and wounds all by itself. Self-healing powers repair skin abrasions and enable bones to grow back together. However, doctors often have to lend a helping hand to repair bones after a fracture or due to a defect. Increasingly, bone replacement materials are being used, which partially or completely restore the form and function of the bone at the site of the…
Biomedical engineering researchers at Texas A&M University designed a medical device that mimics blood vessels to design and monitor drugs for patients with clotting disorders. This approach could be especially beneficial for pediatric patients. Unlike what a biology textbook may show, blood vessels are not straight cylinders. They are tortuous, meaning they have complex curves, spirals and…
The drug nimodipine could prevent nerve cells from dying after brain surgery. Pharmacists at Martin Luther University Halle-Wittenberg (MLU), in cooperation with neurosurgeons at University Hospital Halle (Saale) (UKH), have developed a new method that enables the drug to be administered directly in the brain with fewer side effects. Their findings were published in the European Journal of…
Siemens Healthineers announced today that it is now shipping worldwide its laboratory-based total antibody test1 to detect the presence of SARS-CoV-2 IgM and IgG antibodies in blood.
Researchers at the University of Zurich have developed a new X-ray contrast agent which is easier to use and distributes into all blood vessels more reliably, increasing the precision of vascular imaging. This reduces the number of animals required in research experiments. Various diseases in humans and animals – such as tumors, strokes or chronic kidney disease – damage the blood vessels.…
Researchers at Hokkaido University have succeeded in detecting anti-avian influenza virus antibody in blood serum within 20 minutes, using a portable analyzer they have developed to conduct rapid on-site bio tests. If a suitable reagent is developed, this technology could be used to detect antibodies against SARS-CoV-2, the causative virus of COVID-19.
A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell travelling through the circulatory system. It has the shape, the size and the moving capabilities of leukocytes and could perhaps be well on its way – in a rolling motion of course – to revolutionize the minimally invasive treatment of…
The organ of balance in the inner ear is surrounded by the hardest bone in the body. Using synchrotron X-rays, researchers at Uppsala University have discovered a drainage system that may be assumed to play a major role in the onset of Ménière's disease, a common and troublesome disorder. These results are published in the journal Scientific Reports. Ménière's disease is manifested in sudden…
COVID-19 can cause serious cardiovascular complications including heart failure, heart attacks and blood clots that can lead to strokes, emergency medicine doctors at the University of Virgina report in a new scientific paper. They also caution that COVID-19 treatments can interact with medicines used to manage patients’ existing cardiovascular conditions.
As Covid-19 spreads throughout the country, much attention has been paid to the devastating effects of the virus on the lungs. But doctors are learning how the virus may affect other organs, including the brain. Some patients with Covid-19 have had neurological symptoms, which may include an increased risk of stroke.
A course of action to early detect and treat severe courses of COVID-19 infections has been developed by an expert-team of the University Medical Center Goettingen (UMG). A simple urine test is intended to help medical professionals to recognize warning signs of future decompensation of COVID-19 infections earlier. With the help of a few parameters, the treatment of imminent complications can…
A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis.
Aspirin is associated with a reduction in the risk of developing several cancers of the digestive tract, including some that are almost invariably fatal, such as pancreatic and liver cancers.
An international team led by University of British Columbia (UBC) researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts. The findings, published in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the…
A group of researchers led by Leif Schröder from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have found a way to detect metastases in certain types of cancer in the brain at an early stage, using only minimal amounts of contrast agent. To this end, the team uses a synthetic molecule that helps to detect the formation of new blood vessels, producing much more sophisticated…
Diseases of the brain are often associated with typical vascular changes. Now, scientists at LMU University Hospital Munich, Helmholtz Research Centre for Environmental Health and the Technical University of Munich (TUM) have come up with a technique for visualising the structures of all the brain's blood vessels – right down to the finest capillaries – including any pathological changes. So…
Glioblastomas are complex, fast-growing malignant brain tumors that are made up of various types of cells. Even with aggressive treatment — which often includes surgery, radiation, and chemotherapy — glioblastomas are difficult to treat, leading to an average survival of 11-15 months. In research published in Science Advances, Xavier Intes, a professor of biomedical engineering at Rensselaer,…
Engineers at Rutgers University have created a tabletop device that combines a robot, artificial intelligence and near-infrared and ultrasound imaging to draw blood or insert catheters to deliver fluids and drugs. Their most recent research results, published in the journal Nature Machine Intelligence, suggest that autonomous systems like the image-guided robotic device could outperform people on…