Search for: "dementia" - 197 articles found

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Article • Subset of wearables

From the wrist into the ear – the potential of hearables

Progress in miniaturising sensor technology has opened up new possibilities for monitoring vital signs outside the hospital environment. A subset of wearables are the so-called hearables – in-ear devices that are well suited for long-term monitoring as they are non-invasive, inconspicuous and easy to fasten. Hearables offer two major benefits: their proximity to the torso and vascular system of…

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Article • BCI

Quantum sensors for next-gen brain-computer interfaces

Connecting the brain with a machine has been a powerful dream of mankind. What used to be science fiction, from the Borg in Star Trek to the Matrix, has become mainstream thanks to Elon Musk and Mark Zuckerberg who have put their entrepreneurial commitments into the area of neurotechnology. Recently, Professor Surjo R. Soekadar outlined current and upcoming applications of brain-computer…

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CSF and Alzheimer’s Disease Diagnostics

Sarstedt – CSF false-bottom tube

Highlights:Excellent recovery thanks to low-binding propertiesRoutine-use primary container for sample collection and automated analyticsPatient-friendly sample volume of 2.5 mlCost-effective alternative to PET scanReliable pre-analytics for optimum sample integrityThe new CSF false-bottom tube (art. no.: 63.614.625) meets the requirements for reliable pre-analytics in Alzheimer’s disease…

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News • Brain stimulation

Infrared light helmet might aid dementia patients

Researchers at Durham University are working on a new infrared light therapy that might have the potential to help people with dementia. In the approach, people wear a specially adapted helmet which delivers infrared light deep into the brain for six-minutes per treatment. This stimulates mitochondria that generate most of the chemical energy needed to power the biochemical reaction in the…

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News • microRNAs hint at cognitive decline

Researchers find warning signs for dementia in the blood

esearchers at the DZNE and the University Medical Center Göttingen (UMG) have identified molecules in the blood that can indicate impending dementia. Their findings, which are presented in the scientific journal “EMBO Molecular Medicine”, are based on human studies and laboratory experiments. Various university hospitals across Germany were also involved in the investigations.

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News • Dementia prevention

‘Blue spot’ in the brain helps detecting Alzheimer’s early

A miniscule area in the brain, known as the locus coeruleus (LC), or blue spot, can help to identify an increased risk of Alzheimer’s disease at a very early stage. The LC is hidden deep in the brainstem and can only be detected with advanced MRI equipment. Heidi Jacobs (Maastricht University/Harvard Medical School) used MRI scans to show that the tau protein can begin to spread in the LC three…

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News • Prevention of toxic DNA lesions

Promising mechanism to stop Huntington's progression

A new mechanism that stops the progression of Huntington’s disease in cells has been identified by scientists at the University of Cambridge and University College London (UCL), as part of their research groups at the UK Dementia Research Institute. Researchers say the breakthrough study, published in Cell Reports, could lead to much needed therapies for the rare genetic disease, which is…

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Article • Neurology

Supercomputer helps create 3D synthetic brain models

Scientists are using artificial intelligence (AI) and the Cambridge-1 supercomputer to synthesise artificial 3-D MRI images of human brains and create models that show disease states across various ages and genders. The Synthetic Brain Project is focused on building deep learning models which have been developed by King’s College London (KCL) and NVIDIA data scientists and engineers as part of…

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News • Underrated lipids

The importance of 'beige' fat in dementia protection

Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection from dementia. They have found that beige fat cells, which are typically intermingled with white fat cells in the subcutaneous fat present on “pear shaped” people, mediate…

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News • Early diagnosis proteins

Study identifies 15 new biomarkers for pre­-dementia

A study by an international research group identified 15 novel biomarkers that are linked to late-onset dementias. These biomarkers are proteins, which predict cognitive decline and subsequent increased risk of dementia already 20 years before the disease onset. The proteins are related to immune system dysfunction, blood-brain-barrier dysfunction, vascular pathologies, and central insulin…

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News • Preventive potential

Tell-tale signs of heightened stroke risk may appear up to 10 years earlier

The tell-tale signs of a person’s susceptibility to a stroke may appear up to 10 years before the event, suggests research published online in the Journal of Neurology Neurosurgery & Psychiatry. Stroke patients experienced much steeper declines in cognitive abilities and routine daily functioning, starting around a decade before their first stroke, than people who didn’t have a stroke,…

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News • Neuroscience

A deep dive into the brain

Researchers from ETH Zurich and University of Zurich have developed a new microscopy technique that lights up the brain with high resolution imagery. This allows neuroscientists to study brain functions and ailments more closely and non-​invasively.

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News • Prevention, treatment, care and support

Action on stroke: Experts launch joint declaration

An appeal is launched for Health Ministries across Europe to sign the Declaration for Action on the Stroke Action Plan for Europe to tackle one of the leading causes of death and disability. Led by The European Stroke Organisation (ESO) and Stroke Alliance for Europe (SAFE), the initiative aims to encourage European countries to show their commitment to improving stroke prevention, treatment,…

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News • Challenges of an aging society

Dementia and gun ownership: an issue that needs regulation

In Sweden, there are over 2 million legally owned firearms. At the same time, up to 150,000 people live with a diagnosis of dementia. In an aging society such as Sweden, legislators will face challenges in gun ownership. A new registry-based observational study by researchers from NVS, Karolinska Institutet, published in the Journal of Alzheimer’s Disease shows a need for strategies for this…

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News • Understanding myelination

Multiple sclerosis: Mini '3D brains' to speed up research

Tiny 3D models that mimic vital aspects of the human nervous system have been developed in a step that could accelerate drug research for neurological conditions such as multiple sclerosis (MS). The millimetre-wide models – created using stem cells from human skin samples – will be used to study myelin, an insulating substance that helps nerve cells communicate with each other. Researchers…

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News • Tau pathology in the brain

Defining the 4 subtypes of Alzheimer's

Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in Nature Medicine.

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News • Neurodegeneration research

Alzheimer's: Faster accumulation of tau protein in women's brains

Alzheimer’s disease seems to progress faster in women than in men. The protein tau accumulates at a higher rate in women, according to research from Lund University in Sweden. The study was recently published in Brain. Over 30 million people suffer from Alzheimer’s disease worldwide, making it the most common form of dementia. Tau and beta-amyloid are two proteins known to aggregate and…

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Article • Shaping daily activities for elderly fragile people

Meet 'Tessa' the little robot helper

‘Hello Tessa. Do you know what I’m doing today?’ a fragile, elderly woman asks tentatively. The small robot she’s addressing has a decorative plant on its head and is wearing a jacket. This is not a funny fantasy. Tessa has proved ‘her’ usefulness and acceptability. The little robot results from a year-long pilot project recently completed in the Netherlands by the Groene Kruis…

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News • Nanoparticle-based contrast agent SAIO

New MRI contrast agent to improve upon gadolinium-based products

Magnetic resonance imaging (MRI) is widely used to identify the narrowing or blockage of blood vessels. Contrast agents improve the visibility of the structures and offer more accurate information of vascular conditions such as vascular blockage and stenosis. Commonly used gadolinium-based contrast agents must be administered in chelated forms due to the gadolinium ions' high toxicity and pose…

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News • Women's health

Hypertension symptoms in women often mistaken for menopause

Pregnancy complications and early menopause increase women’s future risk of heart disease. Cardiologists, gynaecologists and endocrinologists recommend how to help middle-aged women prevent later heart problems in a European Society of Cardiology (ESC) consensus document published in European Heart Journal, a journal of the ESC.

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News • Simulated system

New AI approach to find treatments for brain disorders

Getting computers to “think” like humans is the holy grail of artificial intelligence, but human brains turn out to be tough acts to follow. The human brain is a master of applying previously learned knowledge to new situations and constantly refining what’s been learned. This ability to be adaptive has been hard to replicate in machines. Now, researchers at the Salk Institute have used a…

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News • Decreasing infection risk

Researchers develop touch-free vital signs monitor

Scientists at Heriot-Watt University have developed a technique that monitors a patient’s vital signs completely touch free. By using a continuous wave radar-based system to sense tiny chest movements, the new method can accurately measure an individual’s heart rate and respiratory rate without the need for wires, probes, wearable technology or other skin attachments. It could also identify…

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News • White matter hyperintensities

High blood pressure puts the brain at risk

Higher than normal blood pressure is linked to more extensive brain damage in the elderly, according to a new study published in the European Heart Journal. In particular, the study found that there was a strong association between diastolic blood pressure (the blood pressure between heart beats) before the age of 50 and brain damage in later life, even if the diastolic blood pressure was within…

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Article • Overheard at AAIC 2020

Exciting Alzheimer's findings: ’flu vaccines and P-tau217

More than 32,000 people from over 160 countries registered for The Alzheimer’s Association International Conference (AAIC 2020) in July. This largest and most influential international conference on dementia science had to be held virtually this year, when important highlights were aired. The ability to identify individuals at high risk of developing Alzheimer’s Disease (AD), or at early…

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Article • Neuroradiology

Alzheimer’s research: A lost century

Lack of understanding around Alzheimer’s disease (AD) has significantly slowed advances in the treatment of this incurable condition. Imaging has proved to be reliable in differentiating between AD and other forms of dementia, and its contribution will continue to help develop profiling, an increasingly interesting approach for the development of new and more efficient drugs, according to Sven…

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News • Demographic disconnect

Covid-19 drives telehealth (but older people might get left behind)

The Covid-19 pandemic has led to a significant increase in video visits between patients and their doctors, but for many older adults, the shift has cut them off from care, rather than connecting them. A study by researchers at the University of California San Francisco has found that more than a third of adults over age 65 face potential difficulties seeing their doctor via telemedicine, with…

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News • Prevention research

These 10 risk factors must be tackled to prevent Alzheimer's

There are at least 10 risk factors that appear to have a significant impact on a person’s likelihood of developing Alzheimer’s disease that could be targeted with preventative steps, new research suggests. Focusing on these factors, which include cognitive activity, high body mass index in late life, depression, diabetes, and high blood pressure, could provide clinicians with an evidence…

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News • Rad Companion

Siemens expands AI portfolio in clinical decision-making

The AI-Rad Companion family supports radiologists, radiation oncologists, radiotherapists and medical physicists through automated post processing of MRI, CT and X-ray datasets. It saves the clinicians' time and helps them to increase their diagnostic precision.

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Article • FDG-PET imaging of the brain

The nuclear medicine approach to Alzheimer’s

Nuclear Medicine techniques have an important role in the clinical diagnosis of patients with cognitive impairment. And such techniques are not only valuable in a clinical setting but also in research, according one of the leading experts in the field, Javier Arbizu, who is Professor of Radiology and Nuclear Medicine at the Faculty of Medicine at the University of Navarra, Spain.

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News • Neurodegeneration

Alzheimer research: Noise-inducing neurons shut down memories

Neurons that are responsible for new experiences interfere with the signals of neurons that contain memories and thereby disturb the recall of memories – at least in mice. The research group of Martin Fuhrmann of the German Center for Neurodegenerative Diseases (DZNE) reports this phenomenon in the scientific journal “Nature Neuroscience“. The results of this study potentially shed new…

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Article • Bringing AI to the clinics

Pioneering a vendor neutral AI system

Capturing all the possibilities brought by AI long-seemed a faraway dream for hospitals, since most artificial intelligence (AI) solutions are vendor dependent, thus complicating their deployment in clinical practice. However, the dream has become reality at Utrecht UMC, which launched a pioneering AI infrastructure able to monitor information and run any algorithm from its HIS, RIS and PACS.…

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News • Smart algorithm

Automated analysis of whole brain vasculature

Diseases of the brain are often associated with typical vascular changes. Now, scientists at LMU University Hospital Munich, Helmholtz Research Centre for Environmental Health and the Technical University of Munich (TUM) have come up with a technique for visualising the structures of all the brain's blood vessels – right down to the finest capillaries – including any pathological changes. So…

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News • Dementia diagnostics

Lack of sleep might throw off Alzheimer’s test

A preliminary study has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau, a biomarker for Alzheimer’s disease, in their blood than when they had a full, uninterrupted night of rest. The study is published in the January 8, 2020, online issue of Neurology, the medical journal of the American Academy of Neurology. Tau is a protein found in…

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Video • PET precision brain imaging

‘Tau’ protein far more predictive for Alzheimer's damage than amyloid

Brain imaging of pathological tau-protein “tangles” reliably predicts the location of future brain atrophy in Alzheimer’s patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center. In contrast, the location of amyloid “plaques,” which have been the focus of Alzheimer’s research and drug development for decades, was found…

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News • Ivermectin licensing in the UK

Why a much-needed scabies medicine is being kept back

A medicine that could control outbreaks of scabies in the UK is unlicensed and only available through specialist importers, researchers at Brighton and Sussex Medical School (BSMS) have found. In July 2019, the World Health Organization (WHO) updated its model list of essential medicines to include oral ivermectin for scabies-related infections. This recommendation follows the 2017 WHO…

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News • Machine learning for the mind

Astrophysics and AI team up for early dementia diagnosis

Crucial early diagnosis of dementia in general practice could improve thanks to a computer model designed in a collaboration between Brighton and Sussex Medical School (BSMS) and astrophysicists at the University of Sussex. Currently, only two-thirds of people with dementia in the UK receive a formal diagnosis, and many receive it late in the disease process, meaning that a large number are…

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News • New insights into brain diseases

Inflammatory processes drive Alzheimer's progression

Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn comes to this conclusion in the journal “Nature”. The findings are based on the analyses of human brain tissue and further lab…

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News • ‘Smart’ approach to AF

mHealth to help detect atrial fibrillation

A new study, presented as ‘Late Breaking Science’ at the European Society of Cardiology (ESC) annual congress, highlights the feasible use of mobile health (mHealth) devices to help with the screening and detection of atrial fibrillation (AF), a common heart condition. AF causes an irregular and sometimes, abnormally fast heart rate. The heart’s upper chambers (atria) contract randomly and…

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Article • Wishlist

Cancer prevention scrutinised

The latest study by the German Society for Haematology and Oncology (DGHO), ‘Prognosis for population-based morbidity for common cancers in Germany – impact on provision’ has made it clear that due to demographic developments in Germany and to medical advances in oncology, the requirements for cancer patients’ care are ever more diverse. The increase in newly diagnosed cancer patients is…

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News • Hot, spicy & dangerous

Chili lovers might increase dementia risk

Think twice before adding that extra kick of chili sauce or chopped jalapeno to your meal. New research involving the University of South Australia shows a spicy diet could be linked to dementia. A 15-year study of 4582 Chinese adults aged over 55 found evidence of faster cognitive decline in those who consistently ate more than 50 grams of chili a day. Memory decline was even more significant if…

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Article • Is the problem also the solution?

Why digitisation pushes (and prevents) physician burnout

Deployment of electronic health records (EHR) are increasingly cited as a factor in physician burnout. However, a senior figure with the Healthcare Information and Management Systems Society (HIMSS) – which supports the transformation of health through information and technology – believes defined use of data and information can help off-set the impact of burnout among health professionals.…

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News • Virtual reality

VR spots navigation problems in early Alzheimer’s disease

Virtual reality (VR) can identify early Alzheimer’s disease more accurately than ‘gold standard’ cognitive tests currently in use, suggests new research from the University of Cambridge. The study highlights the potential of new technologies to help diagnose and monitor conditions such as Alzheimer’s disease, which affects more than 525,000 people in the UK. In 2014, Professor John…

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Sponsored • Hematology

Early sepsis indicator helps identifying patients at risk

The critical element of testing for sepsis lies not so much in the location but in the timing and rapidity of results, according to Professor Jeannine T. Holden from Beckman Coulter Early identification enables treatment protocols to be delivered more quickly, offering better patient outcomes. Those most at risk, suggests Holden, are not patients within the intensive care unit – who are already…

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News • Dementia pathway

Is LATE the new Alzheimer’s?

A recently recognized brain disorder that mimics clinical features of Alzheimer’s disease has for the first time been defined with recommended diagnostic criteria and other guidelines for advancing and catalyzing future research. Scientists from several National Institutes of Health-funded institutions, in collaboration with international peers, described the newly-named pathway to dementia,…

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News • Magnetic resonance elastography

Faster than fMRI: Seeing brain activity in ‘almost real time’

The speed of the human brain is remarkable. Almost immediately upon being exposed to stimuli, neurons are activated, prompting subconscious reactions and, a fraction of a second later, thought. But the speed at which we can noninvasively follow brain function using an MRI is not as impressive. Functional MRI (fMRI), which measures changes in blood-oxygen levels, has revolutionized neuroscience by…

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Article • Meeting of the generations

We need a Senior Laboratory

It’s undeniable: the bulk of our population is growing older. Yet, this demographic change has not altered laboratory medicine: the reference values for many analyses are still based on data of a younger cohort. Inevitably this could lead to serious errors in the interpretation of older patients’ test results.

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Interview • Predicting the truth from hybrid imaging

Holomics: a trendy but complex topic

‘Is it possible to know whether a treatment will work before even starting it – in other words, to predict the truth? That’s the great promise of holomics, a concept that everyone has been involved in without even noticing,’ said leading French physicist Irène Buvat, from the In Vivo Molecular Imaging French lab, who is set to focus on this subject at ECR 2019. ‘The truth,’ said…

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Article • T-2-weighted imaging

When the brain turns white

White matter on the brain is a difficult subject. Even the terminology is varied, making differential diagnosis complex. An understanding of prevalence and of the tools available to facilitate the diagnosis of individual diseases is important, Dr Gunther Fesl, radiologist at Praxis Radiologie Augsburg, explains.

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News • Neurodegeneration

Will education save you from dementia? Don't count on it

Until now, neurologists were largely convinced that having a higher level of education would build some kind of protective barrier against neurodegenerative diseases like Alzheimer's. But a new study finds that education does not play a role in when the disease starts or how fast it progresses. The study was published in the online issue of Neurology, the medical journal of the American Academy…

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News • Get some rest

Sleep deprivation accelerates Alzheimer’s brain damage

Poor sleep has long been linked with Alzheimer’s disease, but researchers have understood little about how sleep disruptions drive the disease. Now, studying mice and people, researchers at Washington University School of Medicine in St. Louis have found that sleep deprivation increases levels of the key Alzheimer’s protein tau. And, in follow-up studies in the mice, the research team has…

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News • Keeping a clear head

Alzheimer's: key to early prediction in the blood

Alzheimer's disease is often marked by a creeping progression: Years before symptoms of Alzheimer’s disease manifest, the brain starts changing and neurons are slowly degraded. Scientists at the German Center for Neurodegenerative Diseases (DZNE), the Hertie Institute for Clinical Brain Research (HIH) and the University Hospital Tübingen now show that a protein found in the blood can be used…

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Article • Neuroradiology

Dementia – MRI is the first step in diagnosis

Brain imaging in patients with cognitive complaints need to be viewed differently when using MRI to diagnose and treat patients with dementia, says Dr. Christopher Hess, who will discuss the role of MRI in the adjunctive diagnosis of dementia in his talk at the Garmisch Symposium. In addition, general radiologists need to recognize the important findings related to dementia when making a…

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Article • Infection control

Local antibiotics improve results

Hip and knee joint surgeries are among the most common procedures in orthopaedics and trauma surgery and complications can occur. Rare, but serious, among these is periprosthetic joint infection (PJI), which causes high costs in healthcare and stress for patients. PJI is caused by microorganisms that form a biofilm on the surface of the implant and, in this sessile state, they are difficult to…

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Article • Digital PET imaging

Digital Photon Counting improves diagnostic accuracy

Built as the first commercially available scanner to deliver truly digital PET, the Vereos PET/CT, from Philips, offers revolutionary Digital Photon Counting technology. The science behind this scanner evolution is ‘quite complicated’, agrees Piotr Maniawski, Director of Clinical Science Nuclear Medicine at Philips Healthcare, yet the improved performance is significant, particularly when…

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News • Promising predictions

Will MRI be able to predict dementia?

One day, MRI brain scans may help predict whether older people will develop dementia, new research suggests. In a small study, MRI brain scans predicted with 89 percent accuracy who would go on to develop dementia within three years, according to research at Washington University School of Medicine in St. Louis and the University of California San Francisco. The findings, presented at the…

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News • World Alzheimer’s Awareness Month

Robot helps with early screening for Alzheimer’s patients

Alzheimer’s is the most common form of dementia. The US Centers for Disease Control and Prevention reports as many as five million Americans had the disease in 2013. They estimate that by 2050, nearly 14 million will have it. Age is the best known risk factor and memory loss is at the forefront of symptoms. Researchers of the Michigan Technological University investigate how technology can…

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News • Study

Liver disease drug could help restore cells damaged by Alzheimer's

A drug which has been used to treat liver disease for decades could help to restore cells damaged by Alzheimer's, a new study from the University of Sheffield has found. The pioneering study discovered the drug ursodeoxycholic acid (UDCA) improves mitochondrial dysfunction – which is known to be a causative factor for both sporadic and familial Alzheimer's disease.

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News • Dementia

Drinking will put your brain at risk (but then again, abstinence might, too)

People who abstain from alcohol or consume more than 14 units a week during middle age (midlife) are at increased risk of developing dementia, finds a study in The BMJ today. However, the underlying mechanisms are likely to be different in the two groups. As people live longer, the number living with dementia is expected to triple by 2050. So understanding the impact of alcohol consumption on…

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News • Neurology

A new therapy for common cause of dementia?

Scientists have uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people. Studies with rats found the treatment can reverse changes in blood vessels in the brain associated with the condition, called cerebral small vessel disease.

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News • Gait analysis

What your walk says about your health

The way you walk can reveal current and future health problems. New research from Halmstad University suggests the use of wearable sensors for analysing your movement. This can potentially result in early detection of for example Parkinson’s disease, dementia, multiple sclerosis and other neuro-physiological disorders. Many of our body systems, such as the cardio-vascular system and the…

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News • Life's a game

"Exergaming" may help prevent Alzheimer’s

Older adults with mild cognitive impairment (MCI), often a precursor to Alzheimer’s, showed significant improvement with certain complex thinking and memory skills after exergaming, according to a new study. The results could encourage seniors, caregivers and health care providers to pursue or prescribe exergames (video games that also require physical exercise) in hopes of slowing the…

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News • Astrozytes

The brain’s “rising stars”: New options against Alzheimer’s?

A study by scientists of the German Center for Neurodegenerative Diseases (DZNE) points to a novel potential approach against Alzheimer’s disease. In studies in mice, the researchers were able to show that blocking a particular receptor located on astrocytes normalized brain function and improved memory performance. Astrocytes are star-shaped, non-neuronal cells involved in the regulation of…

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News • The power of sound

Music activates regions of the brain spared by Alzheimer’s disease

Ever get chills listening to a particularly moving piece of music? You can thank the salience network of the brain for that emotional joint. Surprisingly, this region also remains an island of remembrance that is spared from the ravages of Alzheimer’s disease. Researchers at the University of Utah Health are looking to this region of the brain to develop music-based treatments to help alleviate…

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Article • GCCA/GBCA safety

Gadolinium @ ECR 2018 – diverse and “disunited”?

Gadolinium-containing/gadolinium-based contrast agents (GCCAs/GBCAs) and their usage was a major topic at ECR 2018. Fuelled by the current debate a number of presentations focused on possible impact, risks and necessities. Some were highly specific, others took a broader view. The only consensus, however, seems to be the need for more research and the focus on safety. Three ECR speakers, Joseph…

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News • Long-term caffeine

There's a catch to your daily coffee intake, study finds

A study coordinated by the Institute of Neuroscience of the Universitat Autònoma de Barcelona (Inc-UAB) and in collaboration with the Karolinska Institutet (KI) in Sweden provides evidence that a long-term consumption of caffeine has negative effects for Alzheimer’s disease, worsening the neuropsychiatric symptoms appearing in the majority of those affected by the disorder. The research was…

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News • Alzheimer’s, Parkinson’s and Huntington’s

The role of misfolded proteins in neurodegenerative diseases

Alzheimer’s, Parkinson’s and Huntington’s disease may have more in common than their effects on the functions of the brain and spinal cord. And finding that common thread could lead to a treatment that could work for all three. A recent study by David Smith, associate professor of biochemistry in the West Virginia University School of Medicine, suggests that at the heart of all three…

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News • Memory-Driven Computing

Time lapse for dementia research

The German Center for Neurodegenerative Diseases (DZNE) is just starting the operation of a new high-performance computer in Bonn. It should significantly accelerate the evaluation of biomedical data and thus lead to faster progress in dementia research. For this the computer uses the principles of the novel computer architecture "Memory-Driven Computing". Time is running out: Dementias…

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News • Anti-rejection medicine

Drugs used after organ transplant could protect against Alzheimer’s

A UT Southwestern study in mice provides new clues about how a class of anti-rejection drugs used after organ transplants may also slow the progression of early-stage Alzheimer’s disease. Alzheimer’s, a progressive form of dementia, affects an estimated 5 million people in the U.S. – a number expected to nearly triple by 2050. Although Alzheimer’s usually strikes after age 65, changes in…

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News • Betanin for the brain

'Beeting' Alzheimer's with vital vegetable compound

A compound in beets that gives the vegetable its distinctive red color could eventually help slow the accumulation of misfolded proteins in the brain, a process that is associated with Alzheimer’s disease. Scientists say this discovery could lead to the development of drugs that could alleviate some of the long-term effects of the disease, the world’s leading cause of dementia. The…

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News • Early dementia diagnosis

Brain imaging provides clues about memory loss

University of California, Irvine-led researchers, however, have found that high-resolution functional magnetic resonance imaging of the brain can be used to show some of the underlying causes of differences in memory proficiency between older and younger adults. The study involved 20 young adults (ages 18 to 31) and 20 cognitively healthy older adults (ages 64 to 89). In the study, the…

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News • Award

DZNE researcher receives world’s top Brain Prize

Together with three other neuroscientists Professor Christian Haass, speaker of the German Center for Neurodegenerative Diseases (DZNE) Munich site and Professor at the Ludwig-Maximilians-University of Munich, receives the world’s most valuable prize for brain research. The 2018 Brain Prize, awarded by the Lundbeck Foundation in Denmark, is worth one million Euros. Awarded annually, it…

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Article • MRI vs. Alzheimer's

Seeking leaks in the blood-brain barrier

‘With our new MRI method, we can finally visualise tiny leaks in the blood-brain barrier. They shed light on the vascular contribution to dementia and may indicate Alzheimer’s disease. However, the MRI scan is only a tool to diagnose cerebrovascular damage. We have not yet found a cure for Alzheimer’s,’ confirms Walter H Backes, medical physicist and professor at Maastricht University…

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Article • Microbleed detection

A new hope for Alzheimer's prediction

New information on dementia biomarkers is emerging, as increasing results from population studies become available. However, although the list of risk factors lengthens, the value of these predictors, and more generally the cause of disease, remain to be determined, according to Gabriel Krestin, professor and chairman of the Department of Radiology & Nuclear Medicine at Erasmus MC, University…

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Article • Compelling cohorts

Population imaging: Big Data will boost disease prediction

Population imaging is key to determining disease prediction and risk prevention, and Big Data will be key to extracting information and drawing analysis from imaging results, experts highlighted during the annual meeting of the European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) held in Barcelona in October. Interest in cohort studies has been increasing over the years and…

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News • In wine, there’s health

Low levels of alcohol might actually be good for your brain

While a couple of glasses of wine can help clear the mind after a busy day, new research shows that it may actually help clean the mind as well. The new study, which appears in the journal Scientific Reports, shows that low levels of alcohol consumption tamp down inflammation and helps the brain clear away toxins, including those associated with Alzheimer’s disease. “Prolonged intake of…

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News • Power up your brain

Exercising may improve thinking ability and memory

Exercising twice a week may improve thinking ability and memory in people with mild cognitive impairment (MCI), according to a guideline released by the American Academy of Neurology. The recommendation is an update to the AAN’s previous guideline on mild cognitive impairment and is published in the online issue of Neurology, the medical journal of the American Academy of Neurology. The…

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News • Leafy greens vs. Alzheimer's

Putting a fork in cognitive decline

While cognitive abilities naturally decline with age, eating one serving of leafy green vegetables a day may aid in preserving memory and thinking skills as a person grows older, according to a study by researchers at Rush University Medical Center in Chicago. The study results were published in Neurology, the medical journal of the American Academy of Neurology. “Adding a daily serving of…

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News • Keep on moving

Just 4,000 steps a day to better brain health

Walking more than 4,000 steps a day can improve attention and mental skills in adults ages 60 and older, according to UCLA research published December 12 in a preprint edition of the Journal of Alzheimer’s Disease. Various studies have found that physical activity is important in preventing cognitive decline and dementia in older adults. Cognitive decline occurs when people start having…

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News • Research

Experimental drug interferes with Alzheimer’s mechanisms

The chemical compound “anle138b” eases cognitive deficits and normalizes gene expression in a mouse model of Alzheimer’s disease. Furthermore, the drug seems to close harmful openings in the membrane of nerve cells. An international collaboration reports these findings in the journal “EMBO Molecular Medicine”. The scientists suggest that anle138b should be validated in clinical trials…

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News • Grim prognosis

Number of americans with Alzheimer’s will more than double by 2060

About 15 million Americans will have either Alzheimer’s dementia or mild cognitive impairment by 2060, up from approximately 6.08 million this year, according to a new study by researchers at the UCLA Fielding School of Public Health. The findings highlight the need to develop measures that could slow the progression of the disease in people who have indications of neuropathological changes…

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News • Predicting cognitive decline

Odor identification problems may be a warning bell for dementia

A long-term study of nearly 3,000 adults, aged 57 to 85, found that those who could not identify at least four out of five common odors were more than twice as likely as those with a normal sense of smell to develop dementia within five years. Although 78 percent of those tested were normal – correctly identifying at least four out of five scents – about 14 percent could name just three out…

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Article • Neurological diseases

No health without brain health

A largely aged population is already a reality in some countries, and this will become a worldwide problem by 2047, when the number of the Earth’s old people is likely to surpass the number of young people.

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News • Caudate nucleus

How Alzheimer's puts your brain on autopilot - in a good way

Patients with Alzheimer's disease (AD) have a larger caudate nucleus, a brain area involved in habits and used to navigate in the environment on an autopilot mode, shows for the first time a Canadian-Norwegian study published in Acta Neurologica Scandinavica. Not good news, you may think. Hold on, this could open new research avenues for AD.

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News • Preventing Alzheimer's

$20 million lifestyle intervention trial to prevent cognitive decline

The Alzheimer's Association announced the launch of a $20 million U.S. two-year clinical trial to test the ability of a multi-dimensional lifestyle intervention to prevent cognitive decline and dementia in 2,500 older adults with no current cognitive symptoms but who are at increased risk for later cognitive decline. The announcement was made at the 2017 Alzheimer's Association International…

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News • Brain pathology

New insights into early cognitive markers of Alzheimer's

New research led by the University of Hertfordshire, may significantly change the understanding of cognitive processes that are most impaired at very early stages of Alzheimer's disease. The findings could potentially be used to detect the condition at an earlier stage and improve diagnostic accuracy, by creating new cognitive tests that are more sensitive to brain pathology than ones currently…

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News • Brain activity

Molecular pathway to improved memory discovered

Scientists from Rutgers University have discovered a molecular pathway that could help develop drug therapies to prevent dementia. It could also provide new insights into memory degradation in the elderly.

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News • Alzheimer's

Concussion linked to brain changes in people at genetic risk for Alzheimer's

Moderate-to-severe traumatic brain injury is a known risk factor for diseases that gradually destroy the brain - such as late-onset Alzheimer's disease. Now, a new study links mild traumatic brain injury, or concussion, in people at genetic risk for Alzheimer's to accelerated brain deterioration and mental decline associated with the disease.

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News • Study

Molecular Roots of Alzheimer’s

Scientists at Washington University School of Medicine in St. Louis have detailed the structure of a molecule that has been implicated in Alzheimer’s disease. Knowing the shape of the molecule — and how that shape may be disrupted by certain genetic mutations — can help in understanding how Alzheimer’s and other neurodegenerative diseases develop and how to prevent and treat them.

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Article • MR Fingerprinting

Radiologists will become computer technicians

‘Magnetic resonance imaging is a very dynamic field,’ declared Professor Siegfried Trattnig, head of the Centre of Excellence for High Field MRI in the Department of Biomedical Imaging and Image-guided Therapy, at Vienna Medical University. Indeed, this September, two mega trends emphasised by Trattnig – the shift from qualitative to quantitative imaging and Big Data – dominated the 33rd…

News • Neurology

“Stroke clearly is a brain disease”

“The medical rationale for stroke being a disease of the brain is overwhelming.” This is the key message of an urgent appeal launched by leading neurology experts in The Lancet.1 The authors are making public their concern about the classification of stroke in the draft revision of the “International Statistical Classification of Diseases and Related Health Problems” (ICD) after an…

News • Study

Predict early stages of Alzheimer’s disease

Researchers from Columbia University Medical Center (CUMC), New York State Psychiatric Institute, and NewYork-Presbyterian reported that an odor identification test may prove useful in predicting cognitive decline and detecting early-stage Alzheimer’s disease. Their two studies, presented at the Alzheimer’s Association’s International Conference in Toronto, Canada, suggest that the…

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Article • Home care

Pioneering NHS ‘test beds’

A ‘technology’ project to modernise healthcare for patients with long- term medical conditions is being trialled in the United Kingdom in seven ‘test bed’ initiatives. Test Beds, a term used to describe a technology project resulting from collaborations between the UK’s National Health Service (NHS) and international innovators, aims to harness technology to address issues facing…

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News • Map

How the brain is organized

The age of exploration has long passed, but there is at least one area still largely uncharted: the human brain. Now, a detailed new map by researchers at Washington University School of Medicine in St. Louis lays out the landscape of the cerebral cortex – the outermost layer of the brain and the dominant structure involved in sensory perception and attention, as well as distinctly human…

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News • Neurology

The aging brain's memory functions

A European study led by Umeå University Professor Lars Nyberg, has shown that the dopamine D2 receptor is linked to the long-term episodic memory, which function often reduces with age and due to dementia. This new insight can contribute to the understanding of why some but not others are affected by memory impairment.

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Article • Hybrid

The whole is greater than the sum of its parts

‘The combination of nuclear medicine and modern imaging procedures such as CT and MRI is becoming increasingly important in the diagnosis, treatment planning and aftercare of cancerous diseases,’ explains Professor Katrine Åhlström Riklund, who presides over the newly established European Society for Hybrid Medical Imaging, ESHI.

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News • CUBRIC

Unravel the mysteries of the human brain

Her Majesty Queen Elizabeth II has officially opened the Cardiff University Brain Research Imaging Centre (CUBRIC), a unique neuroimaging research hub in Wales. The facility will seek to provide unprecedented insights into the causes of neurological and psychiatric conditions such as dementia, schizophrenia and multiple sclerosis, as well as an understanding into the mechanisms of a healthy…

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News • Memory

A study shows how the brain switches into memory mode

Researchers from Germany and the USA have identified an important mechanism with which memory switches from recall to memorization mode. The study may shed new light on the cellular causes of dementia. The work was directed by the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE).

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News • Neurology departments

MR applications provide greater efficiency

Siemens Healthcare has launched a range of new MR applications to help hospitals reduce the time needed for MR imaging within neurology. It is estimated that 20 to 25 per cent of all MR examinations are neurological, with the number expected to grow in 2016 (1). The applications have therefore been designed to help organisations increase patient throughput in order to maintain an efficient…

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Interview • Evolution

On the cusp of Medicine 4.0

In the world of technology, the term Industry 4.0 is already well known. Univ-Prof. Dr. rer. nat. Bernhard Wolf has reveals a comparable development in medicine. Smart systems and personalisation have enormous potential, the Professor for Medical Electronics at the Technical University of Munich is convinced.

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News • Mystery solved

Key Element of cellular organization found

St. Jude Children’s Research Hospital scientists have discovered evidence of a mechanism at the heart of amyotrophic lateral sclerosis (ALS) and related degenerative diseases. The research highlights a possible new treatment strategy for the devastating disorders.

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Article • Oophorectomy

Leading expert takes stand against prophylactic oophorectomy

“I am very concerned about the impact that Angelina Jolie has on the media,” Walter Rocca, professor of epidemiology and neurology at the Mayo Clinic in Rochester, Minnesota, stated. He wasn’t hinting to Jolie’s acting choices or waifish silhouette, but to the confusion surrounding her decision to remove her ovaries to prevent ovarian cancer. By Mélisande Rouger

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Article • Neuroradiology

More freedom, more responsibility

She is a neuroradiologist, professor, researcher and now the Medical Director of the Department of Neuroradiology at Dresden University Hospital. Her objectives are ambitious – be it in patient care, research or teaching. Professor Jennifer Linn MD wants to increase the quality of care, drive breakthroughs in research, ignite enthusiasm in students for their future profession and last, but not…

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Article • Robotic Care

Ambient Assisted Living Systems on the rise

New technologies in healthcare and geriatric care promise great benefits. A Congress held by the Evangelical Academy in Berlin, Germany at the end of February provided a platform for discussions around the potential as well as the risks of new technological developments and trends. Furthermore, the event also saw the introduction of an instrument which can be used to check the ethical dimensions…

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News • Event

International Day of Radiology

Radiology will be in the spotlight on November 8, as radiologists celebrate the International Day of Radiology (IDoR) through a series of events and information campaigns to help the public better understand the role of medical imaging in healthcare.

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Healthcare delivery on the move

The recent Swiss eHealth Summit, a Healthcare Information and Management Systems Society (HIMSS) event supported by key organisations, drew 600 leaders from hospitals, policymaking and the industry. Among the key topics: how IT enables access to information in a mobile environment, referred to by speaker Uwe Buddrus as mHealth.

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Strong international feedback gives “MedTech” industry tailwind for exports

Summing up results of the world’s biggest medical trade fair after four days (16 – 19 November 2011) Joachim Schäfer, Managing Director at Messe Düsseldorf, said: “The manufacturers of medical device technology, medical products and medical IT have once again used the framework of MEDICA in Düsseldorf to impressively evidence their operational excellence.

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Lack of dignity for older patients

The Dignity in Practice study followed a number of national reports showing that the NHS does not always treat older people with care, dignity and respect and that the lack of dignified care provided in acute NHS Trusts is a major source of complaint.

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Molecular Imaging for Alzheimer’s Disease May Be Available in Hospitals Within One Year

Researchers the world over are advancing positron emission tomography (PET) as an effective method of early detection for Alzheimer’s disease, a currently incurable and deadly neurological disorder. Three studies presented at SNM’s 58th Annual Meeting are providing new insights into the development of Alzheimer’s disease while opening the door to future clinical screening and treatments.

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Turning data into knowledge

What connects these: dementia research; the development of a procedure for fast, cost efficient gene sequencing; protein research; modern IT infrastructures, and the determination of reimbursement structures for medical procedures? Answer: Two extremely small common denominators: Bits and bytes. This means data and, increasingly, mass data, which now forms the foundation of medicine. The question…

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Unique rooms at Münster Training Hospital

At first glance everything looks real, from the equipment and fittings to gleaming white bed sheets and the pallor of the patient. But something is incongruous: a large mirror opposite the bed is reminiscent of a police interview room. It is the sole suggestion that this hospital room may be unusual. It is. Behind the mirrored glass, medical students indiand a tutor are observing a ‘doctor’…

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Neurological diseases on the rise

„Diseases of the nervous system and the brain occur more frequently than cancer. According to recent calculations of health care costs, they represent a burden of 386 billion euros a year on European economies,“ says Prof. Gérard Said, newly elected president of the European Neurological Society (ENS) at the annual meeting in Berlin, Germany. „This is often greatly underestimated.“

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The two faces of HIV/AIDS in the brain

The Opening Lecture at ECR always draws immense attention. On March 4th, it was the “First Lady of Radiology” as Congress President M. Szczerbo-Trojanowska called her, Professor Dr Anne G. Osborn, University of Utah, USA, who opened the event. The internationally renowned doctor of diagnostic neuroradiology spoke about “The two faces of HIV/AIDS in the brain” – a matter close to her…

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A 7-Tesla in clinical diagnostics?

Most of the 30 institutes around the world that work with a 7-Tesla MRI scanner do not focus on answering questions about the clinical benefit of this field strength; their efforts revolve around the brain and neurosciences. One exception is the Erwin L Hahn, at the Institute for Magnetic Resonance Imaging, which is based at the Zollverein Coal Mine Industrial Complex, a World Heritage Site in…

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The brain - A promising target for multimodal imaging

Integrated PET/MRI systems will permit the simultaneous acquisition of molecular, functional and structural parameters. The combined strengths of PET (high sensitivity and specificity, but relatively low spatial resolution) and MRI (high resolution, but low sensitivity) is the most attractive feature of multimodal imaging with hybrid scanners. Their application could substantially contribute to…

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Bayer presents positive Phase II data with florbetaben

Bayer Schering Pharma AG, Germany, has presented positive data on a global Phase II study with the novel positron emission tomography (PET) tracer florbetaben (BAY 94-9172) at the International Conference on Alzheimer's Disease (ICAD) in Vienna, Austria. This study showed that patients with a clinical diagnosis of Alzheimer´s disease could be differentiated from age-matched healthy volunteers…

Alzheimer disease: positive Phase II data with florbetaben

Bayer Schering Pharma AG, Germany, has presented positive data on a global Phase II study with the novel positron emission tomography (PET) tracer florbetaben (BAY94-9172) at the International Conference on Alzheimer's Disease (ICAD) in Vienna, Austria. This study showed that patients with a clinical diagnosis of Alzheimer´s disease could be differentiated from age-matched healthy volunteers…

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RUT -

A system of national quality registers, established in recent decades in Sweden's health and medical services, now numbers 64 registers. Along with three competence centres, these cover, for example, diabetes mellitus (NRD), dementia (SeDEM), Swedish intensive care (SIR) and acute coronary care (RIKS-HIA), and the Register Ulcer Treatment (RUT), which was added at the dawn of 2007. The latter has…

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Finding new ways of monitoring elderly patients at home

Hungary is going to start a major new collaborative research programme to transform the care of elderly citizens was announced in Hungary. A broad consortium of private and public sector organisations, led by GE Healthcare has secured HUF 895 million (US $4.2 million) from the Hungarian government to research and develop new ways of monitoring the health of elderly citizens in their own homes. …

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MEDICA 2008 opens its doors

When from 19 to 22 November the world's largest medical fair takes place in Dusseldorf, the entire city is in a kind of emergency state: hotels are bustin' out of their seams, traffic periodically comes to a standstill and at night exhibitors and visitors alike crowd the narrow streets of the Altstadt and the fancy hotel bars and enjoy whatever entertainment North Rhine-Westphalia's capital has…

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Further increase in number of exhibitors

The COMPAMED, the leading specialist international trade fair for suppliers to the medical manufacturing market, is held parallel to the MEDICA, the world's largest medical trade fair, each year and showcases the dynamism and innovative power of the medical technology sector. The COMPAMED 2008, High tech solutions for medical technology, will, with around 500 exhibitors from 30 nations, once…

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Neurologists — an endangered species?

Irish and German neurology associations warn of an imminent shortage of neurologists. In Ireland, according to experts the situation is “lacking at best” and “catastrophic at worst”. German physicians as well detect increasing deficiencies in neurological care coverage primarily due to an aging population and concomitant morbidity.

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Treating Alzheimer with a skin patch

“Exelon Patch”, developed by Novartis is the first skin patch to treat patients with mild to moderate Alzheimer disease. The new therapy that has already been approved by the FDA, is said to be more compliant for it causes less incidents of nausea and vomiting.

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Molecular imaging

GE was the first to undertake molecular imaging development on a large scale. 'You have to be a very special company to work in this discipline,' Reinaldo Garcia, President and Chief Executive Officer of GE Healthcare International, pointed out, when we asked for an update on his company's progress in this field

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Article • Information channel

Neurology: Let's get nervous

Neural networks are emblematic of complex systems, so it's no surprise that the field of neurology is eclectic and intricate, too. Main challenges for neurologists are therapies of and research on stroke, seizures, movement disorders such as Parkinson's disease, autoimmune disorders such as multiple sclerosis and dementias such as Alzheimer's disease.

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